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4. A giant exoplanet orbiting a very low-mass star challenges planet formation models

Author

Morales, J. C., Mustill, A. J., Ribas, I., Davies, M. B., Reiners, A., Bauer, F. F., Kossakowski, D., Herrero, E., Rodríguez, E., López-González, M. J., Rodríguez-López, C., Béjar, V. J. S., González-Cuesta, L., Luque, R., Pallé, E., Perger, M., Baroch, D., Johansen, A., Klahr, H., Mordasini, C., Anglada-Escudé, G., Caballero, J. A., Cortés-Contreras, M., Dreizler, S., Lafarga, M., Nagel, E., Passegger, V. M., Reffert, S., Rosich, A., Schweitzer, A., Tal-Or, L., Trifonov, T., Zechmeister, M., Quirrenbach, A., Amado, P. J., Guenther, E. W., Hagen, H. -J., Henning, T., Jeffers, S. V., Kaminski, A., Kürster, M., Montes, D., Seifert, W., Abellán, F. J., Abril, M., Aceituno, J., Aceituno, F. J., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Antona, R., Arroyo-Torres, B., Azzaro, M., Barrado, D., Becerril-Jarque, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Brinkmöller, M., del Burgo, C., Burn, R., Calvo-Ortega, R., Cano, J., Cárdenas, M. C., Guillén, C. Cardona, Carro, J., Casal, E., Casanova, V., Casasayas-Barris, N., Chaturvedi, P., Cifuentes, C., Claret, A., Colomé, J., Czesla, S., Díez-Alonso, E., Dorda, R., Emsenhuber, A., Fernández, M., Fernández-Martín, A., Ferro, I. M., Fuhrmeister, B., Galadí-Enríquez, D., Cava, I. Gallardo, Vargas, M. L. García, Garcia-Piquer, A., Gesa, L., González-Álvarez, E., Hernández, J. I. González, González-Peinado, R., Guàrdia, J., Guijarro, A., de Guindos, E., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Hermelo, I., Arabi, R. Hernández, Otero, F. Hernández, Hintz, D., Holgado, G., Huber, A., Huke, P., Johnson, E. N., de Juan, E., Kehr, M., Kemmer, J., Kim, M., Klüter, J., Klutsch, A., Labarga, F., Labiche, N., Lalitha, S., Lampón, M., Lara, L. M., Launhardt, R., Lázaro, F. J., Lizon, J. -L., Llamas, M., Lodieu, N., del Fresno, M. López, Salas, J. F. López, López-Santiago, J., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Martín, E. L., Martín-Fernández, P., Martín-Ruiz, S., Martínez-Rodríguez, H., Marvin, C. J., Mirabet, E., Moya, A., Naranjo, V., Nelson, R. P., Nortmann, L., Nowak, G., Ofir, A., Pascual, J., Pavlov, A., Pedraz, S., Medialdea, D. Pérez, Pérez-Calpena, A., Perryman, M. A. C., Rabaza, O., Ballesta, A. Ramón, Rebolo, R., Redondo, P., Rix, H. -W., Rodler, F., Trinidad, A. Rodríguez, Sabotta, S., Sadegi, S., Salz, M., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schlecker, M., Schmitt, J. H. M. M., Schöfer, P., Solano, E., Sota, A., Stahl, O., Stock, S., Stuber, T., Stürmer, J., Suárez, J. C., Tabernero, H. M., Tulloch, S. M., Veredas, G., Vico-Linares, J. I., Vilardell, F., Wagner, K., Winkler, J., Wolthoff, V., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Statistical analyses from exoplanet surveys around low-mass stars indicate that super-Earth and Neptune-mass planets are more frequent than gas giants around such stars, in agreement with core accretion theory of planet formation. Using precise radial velocities derived from visual and near-infrared spectra, we report the discovery of a giant planet with a minimum mass of 0.46 Jupiter masses in an eccentric 204-day orbit around the very low-mass star GJ 3512. Dynamical models show that the high eccentricity of the orbit is most likely explained from planet-planet interactions. The reported planetary system challenges current formation theories and puts stringent constraints on the accretion and migration rates of planet formation and evolution models, indicating that disc instability may be more efficient in forming planets than previously thought., Comment: Manuscript author version. 41 pages, 11 figures

Published
2019
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5. The CARMENES search for exoplanets around M dwarfs. Two temperate Earth-mass planet candidates around Teegarden's Star

Author

Zechmeister, M., Dreizler, S., Ribas, I., Reiners, A., Caballero, J. A., Bauer, F. F., Béjar, V. J. S., González-Cuesta, L., Herrero, E., Lalitha, S., López-González, M. J., Luque, R., Morales, J. C., Pallé, E., Rodríguez, E., López, C. Rodríguez, Tal-Or, L., Anglada-Escudé, G., Quirrenbach, A., Amado, P. J., Abril, M., Aceituno, F. J., Aceituno, J., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Jiménez, R. Antona, Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Barrado, D., Becerril, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Bluhm, P., Brinkmöller, M., del Burgo, C., Ortega, R. Calvo, Cano, J., Guillén, C. Cardona, Carro, J., Vázquez, M. C. Cárdenas, Casal, E., Casasayas-Barris, N., Casanova, V., Chaturvedi, P., Cifuentes, C., Claret, A., Colomé, J., Cortés-Contreras, M., Czesla, S., Díez-Alonso, E., Dorda, R., Fernández, M., Fernández-Martín, A., Ferro, I. M., Fuhrmeister, B., Fukui, A., Galadí-Enríquez, D., Cava, I. Gallardo, de la Fuente, J. Garcia, Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Rueda, J. Góngora, González-Álvarez, E., Hernández, J. I. González, González-Peinado, R., Grözinger, U., Guàrdia, J., Guijarro, A., de Guindos, E., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Henning, T., Hermelo, I., Arabi, R. Hernández, Castaño, L. Hernández, Otero, F. Hernández, Hintz, D., Huke, P., Huber, A., Jeffers, S. V., Johnson, E. N., de Juan, E., Kaminski, A., Kemmer, J., Kim, M., Klahr, H., Klein, R., Klüter, J., Klutsch, A., Kossakowski, D., Kürster, M., Labarga, F., Lafarga, M., Llamas, M., Lampón, M., Lara, L. M., Launhardt, R., Lázaro, F. J., Lodieu, N., del Fresno, M. López, López-Comazzi, A., López-Puertas, M., Salas, J. F. López, López-Santiago, J., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Fernández, D. Maroto, Martín, E. L., Martín-Fernández, P., Martín-Ruiz, S., Marvin, C. J., Mirabet, E., Montañés-Rodríguez, P., Montes, D., Moreno-Raya, M. E., Nagel, E., Naranjo, V., Narita, N., Nortmann, L., Nowak, G., Ofir, A., Oshagh, M., Panduro, J., Parviainen, H., Pascual, J., Passegger, V. M., Pavlov, A., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Rabaza, O., Ballesta, A. Ramón, Rebolo, R., Redondo, P., Reffert, S., Reinhardt, S., Rhode, P., Rix, H. -W., Rodler, F., Trinidad, A. Rodríguez, Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schmitt, J. H. M. M., Schöfer, P., Schweitzer, A., Seifert, W., Shulyak, D., Solano, E., Sota, A., Stahl, O., Stock, S., Strachan, J. B. P., Stuber, T., Stürmer, J., Suárez, J. C., Tabernero, H. M., Pinto, M. Tala, Trifonov, T., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Context. Teegarden's Star is the brightest and one of the nearest ultra-cool dwarfs in the solar neighbourhood. For its late spectral type (M7.0V), the star shows relatively little activity and is a prime target for near-infrared radial velocity surveys such as CARMENES. Aims. As part of the CARMENES search for exoplanets around M dwarfs, we obtained more than 200 radial-velocity measurements of Teegarden's Star and analysed them for planetary signals. Methods. We find periodic variability in the radial velocities of Teegarden's Star. We also studied photometric measurements to rule out stellar brightness variations mimicking planetary signals. Results. We find evidence for two planet candidates, each with $1.1M_\oplus$ minimum mass, orbiting at periods of 4.91 and 11.4 d, respectively. No evidence for planetary transits could be found in archival and follow-up photometry. Small photometric variability is suggestive of slow rotation and old age. Conclusions. The two planets are among the lowest-mass planets discovered so far, and they are the first Earth-mass planets around an ultra-cool dwarf for which the masses have been determined using radial velocities., Comment: A&A 627, A49. 26 pages, 17 figures, 6 tables. Press release available at http://www.astro.physik.uni-goettingen.de/~zechmeister/teegarden/teegarden.html. v2: two authors and one reference added

Published
2019
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11. Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19

Author

Marto, J, Strambo, D, Ntaios, G, Nguyen, T, Herzig, R, Czlonkowska, A, Demeestere, J, Mansour, O, Salerno, A, Wegener, S, Baumgartner, P, Cereda, C, Bianco, G, Beyeler, M, Arnold, M, Carrera, E, Machi, P, Altersberger, V, Bonati, L, Gensicke, H, Bolognese, M, Peters, N, Wetzel, S, Magrico, M, Ramos, J, Sargento-Freitas, J, Machado, R, Maia, C, Machado, E, Nunes, A, Ferreira, P, Pinho E Melo, T, Dias, M, Paula, A, Correia, M, Castro, P, Azevedo, E, Albuquerque, L, Alves, J, Ferreira-Pinto, J, Meira, T, Pereira, L, Rodrigues, M, Araujo, A, Rocha, M, Pereira-Fonseca, A, Ribeiro, L, Varela, R, Malheiro, S, Cappellari, M, Zivelonghi, C, Sajeva, G, Zini, A, Gentile, M, Forlivesi, S, Migliaccio, L, Sessa, M, La Gioia, S, Pezzini, A, Sangalli, D, Zedde, M, Pascarella, R, Ferrarese, C, Beretta, S, Diamanti, S, Schwarz, G, Frisullo, G, Marcheselli, S, Seners, P, Sabben, C, Escalard, S, Piotin, M, Maier, B, Charbonnier, G, Vuillier, F, Legris, L, Cuisenier, P, Vodret, F, Marnat, G, Liegey, J, Sibon, I, Flottmann, F, Broocks, G, Gloyer, N, Bohmann, F, Schaefer, J, Nolte, C, Audebert, H, Siebert, E, Sykora, M, Lang, W, Ferrari, J, Mayer-Suess, L, Knoflach, M, Gizewski, E, Stolp, J, Stolze, L, Coutinho, J, Nederkoorn, P, Van Den Wijngaard, I, De Meris, J, Lemmens, R, De Raedt, S, Vandervorst, F, Rutgers, M, Guilmot, A, Dusart, A, Bellante, F, Calleja-Castano, P, Ostos, F, Gonzalez-Ortega, G, Martin-Jimenez, P, Garcia-Madrona, S, Cruz-Culebras, A, Vera, R, Matute, M, Fuentes, B, Alonso-De-Lecinana, M, Rigual, R, Diez-Tejedor, E, Perez-Sanchez, S, Montaner, J, Diaz-Otero, F, Perez-De-La-Ossa, N, Flores-Pina, B, Munoz-Narbona, L, Chamorro, A, Rodriguez-Vazquez, A, Renu, A, Ayo-Martin, O, Hernandez-Fernandez, F, Segura, T, Tejada-Meza, H, Sagarra-Mur, D, Serrano-Ponz, M, Hlaing, T, See, I, Simister, R, Werring, D, Kristoffersen, E, Nordanstig, A, Jood, K, Rentzos, A, Simunek, L, Krajickova, D, Krajina, A, Mikulik, R, Cvikova, M, Vinklarek, J, Skoloudik, D, Roubec, M, Hurtikova, E, Hruby, R, Ostry, S, Skoda, O, Pernicka, M, Jurak, L, Eichlova, Z, Jira, M, Kovar, M, Pansky, M, Mencl, P, Palouskova, H, Tomek, A, Jansky, P, Olserova, A, Sramek, M, Havlicek, R, Maly, P, Trakal, L, Fiksa, J, Slovak, M, Karlinski, M, Nowak, M, Sienkiewicz-Jarosz, H, Bochynska, A, Wrona, P, Homa, T, Sawczynska, K, Slowik, A, Wlodarczyk, E, Wiacek, M, Tomaszewska-Lampart, I, Sieczkowski, B, Bartosik-Psujek, H, Bilik, M, Bandzarewicz, A, Dorobek, M, Zielinska-Turek, J, Nowakowska-Kotas, M, Obara, K, Urbanowski, P, Budrewicz, S, Guzinski, M, Switonska, M, Rutkowska, I, Sobieszak-Skura, P, Labuz-Roszak, B, Debiec, A, Staszewski, J, Stepien, A, Zwiernik, J, Wasilewski, G, Tiu, C, Terecoasa, E, Radu, R, Negrila, A, Dorobat, B, Panea, C, Tiu, V, Petrescu, S, Ozdemir, A, Mahmoud, M, El-Samahy, H, Abdelkhalek, H, Al-Hashel, J, Ismail, I, Salmeen, A, Ghoreishi, A, Sabetay, S, Gross, H, Klein, P, Abdalkader, M, Jabbour, P, El Naamani, K, Tjoumakaris, S, Abbas, R, Mohamed, G, Chebl, A, Min, J, Hovingh, M, Tsai, J, Khan, M, Nalleballe, K, Onteddu, S, Masoud, H, Michael, M, Kaur, N, Maali, L, Abraham, M, Khandelwal, P, Bach, I, Ong, M, Babici, D, Khawaja, A, Hakemi, M, Rajamani, K, Cano-Nigenda, V, Arauz, A, Amaya, P, Llanos, N, Arango, A, Vences, M, Barrientos Guerra, J, Caetano, R, Martins, R, Scollo, S, Yalung, P, Nagendra, S, Gaikwad, A, Seo, K, Georgiopoulos, G, Nogueira, R, Michel, P, Marto J. P., Strambo D., Ntaios G., Nguyen T. N., Herzig R., Czlonkowska A., Demeestere J., Mansour O. Y., Salerno A., Wegener S., Baumgartner P., Cereda C. W., Bianco G., Beyeler M., Arnold M., Carrera E., Machi P., Altersberger V., Bonati L., Gensicke H., Bolognese M., Peters N., Wetzel S., Magrico M., Ramos J. N., Sargento-Freitas J., Machado R., Maia C., Machado E., Nunes A. P., Ferreira P., Pinho E Melo T., Dias M. C., Paula A., Correia M. A., Castro P., Azevedo E., Albuquerque L., Alves J. N., Ferreira-Pinto J., Meira T., Pereira L., Rodrigues M., Araujo A. P., Rocha M., Pereira-Fonseca A., Ribeiro L., Varela R., Malheiro S., Cappellari M., Zivelonghi C., Sajeva G., Zini A., Gentile M., Forlivesi S., Migliaccio L., Sessa M., La Gioia S., Pezzini A., Sangalli D., Zedde M., Pascarella R., Ferrarese C., Beretta S., Diamanti S., Schwarz G., Frisullo G., Marcheselli S., Seners P., Sabben C., Escalard S., Piotin M., Maier B., Charbonnier G., Vuillier F., Legris L., Cuisenier P., Vodret F. R., Marnat G., Liegey J. -S., Sibon I., Flottmann F., Broocks G., Gloyer N. -O., Bohmann F. O., Schaefer J. H., Nolte C., Audebert H. J., Siebert E., Sykora M., Lang W., Ferrari J., Mayer-Suess L., Knoflach M., Gizewski E. R., Stolp J., Stolze L. J., Coutinho J. M., Nederkoorn P., Van Den Wijngaard I., De Meris J., Lemmens R., De Raedt S., Vandervorst F., Rutgers M. P., Guilmot A., Dusart A., Bellante F., Calleja-Castano P., Ostos F., Gonzalez-Ortega G., Martin-Jimenez P., Garcia-Madrona S., Cruz-Culebras A., Vera R., Matute M. C., Fuentes B., Alonso-De-Lecinana M., Rigual R., Diez-Tejedor E., Perez-Sanchez S., Montaner J., Diaz-Otero F., Perez-De-La-Ossa N., Flores-Pina B., Munoz-Narbona L., Chamorro A., Rodriguez-Vazquez A., Renu A., Ayo-Martin O., Hernandez-Fernandez F., Segura T., Tejada-Meza H., Sagarra-Mur D., Serrano-Ponz M., Hlaing T., See I., Simister R., Werring D., Kristoffersen E. S., Nordanstig A., Jood K., Rentzos A., Simunek L., Krajickova D., Krajina A., Mikulik R., Cvikova M., Vinklarek J., Skoloudik D., Roubec M., Hurtikova E., Hruby R., Ostry S., Skoda O., Pernicka M., Jurak L., Eichlova Z., Jira M., Kovar M., Pansky M., Mencl P., Palouskova H., Tomek A., Jansky P., Olserova A., Sramek M., Havlicek R., Maly P., Trakal L., Fiksa J., Slovak M., Karlinski M. A., Nowak M., Sienkiewicz-Jarosz H., Bochynska A., Wrona P., Homa T., Sawczynska K., Slowik A., Wlodarczyk E., Wiacek M., Tomaszewska-Lampart I., Sieczkowski B., Bartosik-Psujek H., Bilik M., Bandzarewicz A., Dorobek M., Zielinska-Turek J., Nowakowska-Kotas M., Obara K., Urbanowski P., Budrewicz S., Guzinski M., Switonska M., Rutkowska I., Sobieszak-Skura P., Labuz-Roszak B. M., Debiec A., Staszewski J., Stepien A., Zwiernik J., Wasilewski G., Tiu C., Terecoasa E. O., Radu R. A., Negrila A., Dorobat B., Panea C., Tiu V., Petrescu S., Ozdemir A., Mahmoud M., El-Samahy H., Abdelkhalek H., Al-Hashel J., Ismail I. I., Salmeen A., Ghoreishi A., Sabetay S. I., Gross H., Klein P., Abdalkader M., Jabbour P., El Naamani K., Tjoumakaris S., Abbas R., Mohamed G. A., Chebl A., Min J., Hovingh M., Tsai J. P., Khan M., Nalleballe K., Onteddu S., Masoud H., Michael M., Kaur N., Maali L., Abraham M. G., Khandelwal P., Bach I., Ong M., Babici D., Khawaja A. M., Hakemi M., Rajamani K., Cano-Nigenda V., Arauz A., Amaya P., Llanos N., Arango A., Vences M. A., Barrientos Guerra J. D., Caetano R., Martins R. T., Scollo S. D., Yalung P. M., Nagendra S., Gaikwad A., Seo K. -D., Georgiopoulos G., Nogueira R. G., Michel P., Marto, J, Strambo, D, Ntaios, G, Nguyen, T, Herzig, R, Czlonkowska, A, Demeestere, J, Mansour, O, Salerno, A, Wegener, S, Baumgartner, P, Cereda, C, Bianco, G, Beyeler, M, Arnold, M, Carrera, E, Machi, P, Altersberger, V, Bonati, L, Gensicke, H, Bolognese, M, Peters, N, Wetzel, S, Magrico, M, Ramos, J, Sargento-Freitas, J, Machado, R, Maia, C, Machado, E, Nunes, A, Ferreira, P, Pinho E Melo, T, Dias, M, Paula, A, Correia, M, Castro, P, Azevedo, E, Albuquerque, L, Alves, J, Ferreira-Pinto, J, Meira, T, Pereira, L, Rodrigues, M, Araujo, A, Rocha, M, Pereira-Fonseca, A, Ribeiro, L, Varela, R, Malheiro, S, Cappellari, M, Zivelonghi, C, Sajeva, G, Zini, A, Gentile, M, Forlivesi, S, Migliaccio, L, Sessa, M, La Gioia, S, Pezzini, A, Sangalli, D, Zedde, M, Pascarella, R, Ferrarese, C, Beretta, S, Diamanti, S, Schwarz, G, Frisullo, G, Marcheselli, S, Seners, P, Sabben, C, Escalard, S, Piotin, M, Maier, B, Charbonnier, G, Vuillier, F, Legris, L, Cuisenier, P, Vodret, F, Marnat, G, Liegey, J, Sibon, I, Flottmann, F, Broocks, G, Gloyer, N, Bohmann, F, Schaefer, J, Nolte, C, Audebert, H, Siebert, E, Sykora, M, Lang, W, Ferrari, J, Mayer-Suess, L, Knoflach, M, Gizewski, E, Stolp, J, Stolze, L, Coutinho, J, Nederkoorn, P, Van Den Wijngaard, I, De Meris, J, Lemmens, R, De Raedt, S, Vandervorst, F, Rutgers, M, Guilmot, A, Dusart, A, Bellante, F, Calleja-Castano, P, Ostos, F, Gonzalez-Ortega, G, Martin-Jimenez, P, Garcia-Madrona, S, Cruz-Culebras, A, Vera, R, Matute, M, Fuentes, B, Alonso-De-Lecinana, M, Rigual, R, Diez-Tejedor, E, Perez-Sanchez, S, Montaner, J, Diaz-Otero, F, Perez-De-La-Ossa, N, Flores-Pina, B, Munoz-Narbona, L, Chamorro, A, Rodriguez-Vazquez, A, Renu, A, Ayo-Martin, O, Hernandez-Fernandez, F, Segura, T, Tejada-Meza, H, Sagarra-Mur, D, Serrano-Ponz, M, Hlaing, T, See, I, Simister, R, Werring, D, Kristoffersen, E, Nordanstig, A, Jood, K, Rentzos, A, Simunek, L, Krajickova, D, Krajina, A, Mikulik, R, Cvikova, M, Vinklarek, J, Skoloudik, D, Roubec, M, Hurtikova, E, Hruby, R, Ostry, S, Skoda, O, Pernicka, M, Jurak, L, Eichlova, Z, Jira, M, Kovar, M, Pansky, M, Mencl, P, Palouskova, H, Tomek, A, Jansky, P, Olserova, A, Sramek, M, Havlicek, R, Maly, P, Trakal, L, Fiksa, J, Slovak, M, Karlinski, M, Nowak, M, Sienkiewicz-Jarosz, H, Bochynska, A, Wrona, P, Homa, T, Sawczynska, K, Slowik, A, Wlodarczyk, E, Wiacek, M, Tomaszewska-Lampart, I, Sieczkowski, B, Bartosik-Psujek, H, Bilik, M, Bandzarewicz, A, Dorobek, M, Zielinska-Turek, J, Nowakowska-Kotas, M, Obara, K, Urbanowski, P, Budrewicz, S, Guzinski, M, Switonska, M, Rutkowska, I, Sobieszak-Skura, P, Labuz-Roszak, B, Debiec, A, Staszewski, J, Stepien, A, Zwiernik, J, Wasilewski, G, Tiu, C, Terecoasa, E, Radu, R, Negrila, A, Dorobat, B, Panea, C, Tiu, V, Petrescu, S, Ozdemir, A, Mahmoud, M, El-Samahy, H, Abdelkhalek, H, Al-Hashel, J, Ismail, I, Salmeen, A, Ghoreishi, A, Sabetay, S, Gross, H, Klein, P, Abdalkader, M, Jabbour, P, El Naamani, K, Tjoumakaris, S, Abbas, R, Mohamed, G, Chebl, A, Min, J, Hovingh, M, Tsai, J, Khan, M, Nalleballe, K, Onteddu, S, Masoud, H, Michael, M, Kaur, N, Maali, L, Abraham, M, Khandelwal, P, Bach, I, Ong, M, Babici, D, Khawaja, A, Hakemi, M, Rajamani, K, Cano-Nigenda, V, Arauz, A, Amaya, P, Llanos, N, Arango, A, Vences, M, Barrientos Guerra, J, Caetano, R, Martins, R, Scollo, S, Yalung, P, Nagendra, S, Gaikwad, A, Seo, K, Georgiopoulos, G, Nogueira, R, Michel, P, Marto J. P., Strambo D., Ntaios G., Nguyen T. N., Herzig R., Czlonkowska A., Demeestere J., Mansour O. Y., Salerno A., Wegener S., Baumgartner P., Cereda C. W., Bianco G., Beyeler M., Arnold M., Carrera E., Machi P., Altersberger V., Bonati L., Gensicke H., Bolognese M., Peters N., Wetzel S., Magrico M., Ramos J. N., Sargento-Freitas J., Machado R., Maia C., Machado E., Nunes A. P., Ferreira P., Pinho E Melo T., Dias M. C., Paula A., Correia M. A., Castro P., Azevedo E., Albuquerque L., Alves J. N., Ferreira-Pinto J., Meira T., Pereira L., Rodrigues M., Araujo A. P., Rocha M., Pereira-Fonseca A., Ribeiro L., Varela R., Malheiro S., Cappellari M., Zivelonghi C., Sajeva G., Zini A., Gentile M., Forlivesi S., Migliaccio L., Sessa M., La Gioia S., Pezzini A., Sangalli D., Zedde M., Pascarella R., Ferrarese C., Beretta S., Diamanti S., Schwarz G., Frisullo G., Marcheselli S., Seners P., Sabben C., Escalard S., Piotin M., Maier B., Charbonnier G., Vuillier F., Legris L., Cuisenier P., Vodret F. R., Marnat G., Liegey J. -S., Sibon I., Flottmann F., Broocks G., Gloyer N. -O., Bohmann F. O., Schaefer J. H., Nolte C., Audebert H. J., Siebert E., Sykora M., Lang W., Ferrari J., Mayer-Suess L., Knoflach M., Gizewski E. R., Stolp J., Stolze L. J., Coutinho J. M., Nederkoorn P., Van Den Wijngaard I., De Meris J., Lemmens R., De Raedt S., Vandervorst F., Rutgers M. P., Guilmot A., Dusart A., Bellante F., Calleja-Castano P., Ostos F., Gonzalez-Ortega G., Martin-Jimenez P., Garcia-Madrona S., Cruz-Culebras A., Vera R., Matute M. C., Fuentes B., Alonso-De-Lecinana M., Rigual R., Diez-Tejedor E., Perez-Sanchez S., Montaner J., Diaz-Otero F., Perez-De-La-Ossa N., Flores-Pina B., Munoz-Narbona L., Chamorro A., Rodriguez-Vazquez A., Renu A., Ayo-Martin O., Hernandez-Fernandez F., Segura T., Tejada-Meza H., Sagarra-Mur D., Serrano-Ponz M., Hlaing T., See I., Simister R., Werring D., Kristoffersen E. S., Nordanstig A., Jood K., Rentzos A., Simunek L., Krajickova D., Krajina A., Mikulik R., Cvikova M., Vinklarek J., Skoloudik D., Roubec M., Hurtikova E., Hruby R., Ostry S., Skoda O., Pernicka M., Jurak L., Eichlova Z., Jira M., Kovar M., Pansky M., Mencl P., Palouskova H., Tomek A., Jansky P., Olserova A., Sramek M., Havlicek R., Maly P., Trakal L., Fiksa J., Slovak M., Karlinski M. A., Nowak M., Sienkiewicz-Jarosz H., Bochynska A., Wrona P., Homa T., Sawczynska K., Slowik A., Wlodarczyk E., Wiacek M., Tomaszewska-Lampart I., Sieczkowski B., Bartosik-Psujek H., Bilik M., Bandzarewicz A., Dorobek M., Zielinska-Turek J., Nowakowska-Kotas M., Obara K., Urbanowski P., Budrewicz S., Guzinski M., Switonska M., Rutkowska I., Sobieszak-Skura P., Labuz-Roszak B. M., Debiec A., Staszewski J., Stepien A., Zwiernik J., Wasilewski G., Tiu C., Terecoasa E. O., Radu R. A., Negrila A., Dorobat B., Panea C., Tiu V., Petrescu S., Ozdemir A., Mahmoud M., El-Samahy H., Abdelkhalek H., Al-Hashel J., Ismail I. I., Salmeen A., Ghoreishi A., Sabetay S. I., Gross H., Klein P., Abdalkader M., Jabbour P., El Naamani K., Tjoumakaris S., Abbas R., Mohamed G. A., Chebl A., Min J., Hovingh M., Tsai J. P., Khan M., Nalleballe K., Onteddu S., Masoud H., Michael M., Kaur N., Maali L., Abraham M. G., Khandelwal P., Bach I., Ong M., Babici D., Khawaja A. M., Hakemi M., Rajamani K., Cano-Nigenda V., Arauz A., Amaya P., Llanos N., Arango A., Vences M. A., Barrientos Guerra J. D., Caetano R., Martins R. T., Scollo S. D., Yalung P. M., Nagendra S., Gaikwad A., Seo K. -D., Georgiopoulos G., Nogueira R. G., and Michel P.

Abstract

Background and Objectives COVID-19–related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19. Methods This was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection. With a doubly robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT). Results Of a total of 15,128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19; of those, 5,848 (38.7%) patients received IVT-only and 9,280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted OR 1.53; 95% CI 1.16–2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20–2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23–1.99), 24-hour mortality (OR 2.47; 95% CI 1.58–3.86), and 3-month mortality (OR 1.88; 95% CI 1.52–2.33). Patients with COVID-19 also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26–1.60). Discussion Patients with AIS and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non–COVID-19 patients receiving treatment. Current available data do not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in patients with COVID-19 or to establish different treatment r

Published
2023

12. Syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) in a patient with confusional symptoms, diffuse EEG abnormalities, and bilateral vasospasm in transcranial Doppler ultrasound: A case report and literature review

Author

Hidalgo de la Cruz, M., Domínguez Rubio, R., Luque Buzo, E., Díaz Otero, F., Vázquez Alén, P., Orcajo Rincón, J., Prieto Montalvo, J., Contreras Chicote, A., and Grandas Pérez, F.

Published
2019
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13. Síndrome de cefalea transitoria con déficits neurológicos asociados y pleocitosis en líquido cefalorraquídeo (HaNDL) con cuadro confusional, EEG compatible con afectación difusa y datos de vasoespasmo bilateral en estudio Doppler transcraneal: presentación de un caso y revisión de la literatura

Author

Hidalgo de la Cruz, M., Domínguez Rubio, R., Luque Buzo, E., Díaz Otero, F., Vázquez Alén, P., Orcajo Rincón, J., Prieto Montalvo, J., Contreras Chicote, A., and Grandas Pérez, F.

Published
2019
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17. FRP Offshore Structure Connections Optimization and Validation by Classification Society standards

Author

Borrás, A., Otero, F., and Martínez, X.

Subjects
Materials Science, Composites
Abstract

This paper discusses the use of composite materials in the design process of a horizontal bracing to column connection of an offshore semi-submersible platform to support two wind turbines. The geometry of the connection was optimized to improve the performance and reliability of the connection, columns and bracing tubes. These offshore foundations usually deal with massive structural tubes, and they are used to fit a huge amount of stiffeners. This paper will show how using some horizontal stiffeners combined with their intersection with horizontal bracings tubes, can improve drastically the behavior of the connection. A comparison between conventional materials (steel) and advanced materials (E-glass fibres and epoxy matrix) was performed and it was demonstrated how the use of composite materials makes necessary to modify the connection geometry and configuration to obtain an equivalent performance. This is due to the very different stiffness behavior shown by composites and steel. Therefore, the design of an offshore connection must be approached differently according to the used material. The composite laminate layout design process was also made. The material was evaluated using a Bureau Veritas normative note specifically applicable to composite ship hulls, but adapted to the needs of the materials used in this design, in terms of raw material requirements. The design process of a laminate panel of the connection is shown using the above mentioned standard. All data and results shown here were harvested within the scope of the European research project Fibregy (EU Horizon 2020, Ref. 952966).

Published
2023

20. Use of healthcare resources and costs of acute cardioembolic stroke management in the Region of Madrid: The CODICE Study

Author

de Andrés-Nogales, F., Vivancos Mora, J., Barriga Hernández, F.J., Díaz Otero, F., Izquierdo Esteban, L., Ortega-Casarrubios, M.Á., Castillo Moreno, L., Ximénez-Carrillo Rico, Á., Martín Torres, M.P., Gómez-Escalonilla Escobar, C.I., Torres González, C., de Salas-Cansado, M., Casado Gómez, M.Á., Soto Álvarez, J., and Gil-Núñez, A.

Published
2015
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21. Utilización de recursos sanitarios y costes asociados al manejo de los pacientes con infarto cerebral cardioembólico agudo en la Comunidad de Madrid: Estudio CODICE

Author

de Andrés-Nogales, F., Vivancos Mora, J., Barriga Hernández, F.J., Díaz Otero, F., Izquierdo Esteban, L., Ortega-Casarrubios, M.Á., Castillo Moreno, L., Ximénez-Carrillo Rico, Á., Martín Torres, M.P., Gómez-Escalonilla Escobar, C.I., Torres González, C., de Salas-Cansado, M., Casado Gómez, M.Á., Soto Álvarez, J., and Gil-Núñez, A.

Published
2015
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26. Clinical management guidelines for subarachnoid haemorrhage. Diagnosis and treatment

Author

Vivancos, J., Gilo, F., Frutos, R., Maestre, J., García-Pastor, A., Quintana, F., Roda, J.M., Ximénez-Carrillo, A., Díez Tejedor, E., Fuentes, B., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Castellanos, M., Castillo, J., Dávalos, A., Díaz-Otero, F., Egido, J.A., Fernández, J.C., Freijo, M., Gállego, J., Gil-Núñez, A., Irimia, P., Lago, A., Masjuan, J., Martí-Fábregas, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Morales, A., Nombela, F., Purroy, F., Ribó, M., Rodríguez-Yañez, M., Roquer, J., Rubio, F., Segura, T., Serena, J., Simal, P., and Tejada, J.

Published
2014
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27. Guía de actuación clínica en la hemorragia subaracnoidea. Sistemática diagnóstica y tratamiento

Author

Vivancos, J., Gilo, F., Frutos, R., Maestre, J., García-Pastor, A., Quintana, F., Roda, J.M., Ximénez-Carrillo, A., Díez Tejedor, E., Fuentes, B., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Castellanos, M., Castillo, J., Dávalos, A., Díaz-Otero, F., Egido, J.A., Fernández, J.C., Freijo, M., Gállego, J., Gil-Núñez, A., Irimia, P., Lago, A., Masjuan, J., Martí-Fábregas, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Morales, A., Nombela, F., Purroy, F., Ribó, M., Rodríguez-Yañez, M., Roquer, J., Rubio, F., Segura, T., Serena, J., Simal, P., and Tejada, J.

Published
2014
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28. Workload of on-call emergency room neurologists in a Spanish tertiary care centre. A one-year prospective study

Author

Rodríguez Cruz, P.M., Pérez Sánchez, J.R., Cuello, J.P., Sobrino García, P., Vicente Peracho, G., García Arratibel, A., Sánchez Guzmán, D., Bravo Quelle, N., Gutiérrez Ruano, B., Alarcón Morcillo, C., Cordido Henríquez, F., Romero Delgado, F., Muñoz González, A., Domínguez Rubio, R., Iglesias Mohedano, A.M., Martín Barriga, M.L., de la Casa Fages, B., Díaz Otero, F., Ezpeleta, D., García Pastor, A., and Gil Núñez, A.

Published
2014
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29. Guía para el tratamiento preventivo del ictus isquémico y AIT (II). Recomendaciones según subtipo etiológico

Author

Fuentes, B., Gállego, J., Gil-Nuñez, A., Morales, A., Purroy, F., Roquer, J., Segura, T., Tejada, J., Lago, A., Díez-Tejedor, E., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Castellanos, M., Castillo, J., Dávalos, A., Díaz-Otero, F., Egido, J.A., López-Fernández, J.C., Freijo, M., García Pastor, A., Gilo, F., Irimia, P., Maestre, J., Masjuan, J., Martí-Fábregas, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Nombela, F., Ribó, M., Rodríguez-Yañez, M., Rubio, F., Serena, J., Simal, P., and Vivancos, J.

Published
2014
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30. Guidelines for the treatment of acute ischaemic stroke

Author

Alonso de Leciñana, M., Egido, J.A., Casado, I., Ribó, M., Dávalos, A., Masjuan, J., Caniego, J.L., Martínez Vila, E., Díez Tejedor, E., Fuentes (Secretaría), B., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Castellanos, M., Castillo, J., Díaz-Otero, F., López-Fernández, J.C., Freijo, M., Gállego, J., García-Pastor, A., Gil-Núñez, A., Gilo, F., Irimia, P., Lago, A., Maestre, J., Martí-Fábregas, J., Martínez-Sánchez, P., Molina, C., Morales, A., Nombela, F., Purroy, F., Rodríguez-Yañez, M., Roquer, J., Rubio, F., Segura, T., Serena, J., Simal, P., Tejada, J., and Vivancos, J.

Published
2014
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31. Guía para el tratamiento del infarto cerebral agudo

Author

Alonso de Leciñana, M., Egido, J.A., Casado, I., Ribó, M., Dávalos, A., Masjuan, J., Caniego, J.L., Martínez Vila, E., Díez Tejedor, E., Fuentes (Secretaría), B., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Castellanos, M., Castillo, J., Díaz-Otero, F., López-Fernández, J.C., Freijo, M., Gállego, J., García-Pastor, A., Gil-Núñez, A., Gilo, F., Irimia, P., Lago, A., Maestre, J., Martí-Fábregas, J., Martínez-Sánchez, P., Molina, C., Morales, A., Nombela, F., Purroy, F., Rodríguez-Yañez, M., Roquer, J., Rubio, F., Segura, T., Serena, J., Simal, P., Tejada, J., and Vivancos, J.

Published
2014
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34. Clinical practice guidelines in intracerebral haemorrhage

Author

Rodríguez-Yáñez, M., Castellanos, M., Freijo, M.M., López Fernández, J.C., Martí-Fàbregas, J., Nombela, F., Simal, P., Castillo, J., Díez-Tejedor, E., Fuentes, B., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Dávalos, A., Díaz-Otero, F., Egido, J.A., Gállego, J., García Pastor, A., Gil-Núñez, A., Gilo, F., Irimia, P., Lago, A., Maestre, J., Masjuan, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Morales, A., Purroy, F., Ribó, M., Roquer, J., Rubio, F., Segura, T., Serena, J., Tejada, J., and Vivancos, J.

Published
2013
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35. Guías de actuación clínica en la hemorragia intracerebral

Author

Rodríguez-Yáñez, M., Castellanos, M., Freijo, M.M., López Fernández, J.C., Martí-Fàbregas, J., Nombela, F., Simal, P., Castillo, J., Díez-Tejedor, E., Fuentes, B., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Dávalos, A., Díaz-Otero, F., Egido, J.A., Gállego, J., García Pastor, A., Gil-Núñez, A., Gilo, F., Irimia, P., Lago, A., Maestre, J., Masjuan, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Morales, A., Purroy, F., Ribó, M., Roquer, J., Rubio, F., Segura, T., Serena, J., Tejada, J., and Vivancos, J.

Published
2013
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36. Labor asistencial del equipo de guardia de neurología en un hospital terciario de Madrid: análisis prospectivo durante un año

Author

Rodríguez Cruz, P.M., Pérez Sánchez, J.R., Cuello, J.P., Sobrino García, P., Vicente Peracho, G., García Arratibel, A., Sánchez Guzmán, D., Bravo Quelle, N., Gutiérrez Ruano, B., Alarcón Morcillo, C., Cordido Henríquez, F., Romero Delgado, F., Muñoz González, A., Domínguez Rubio, R., Iglesias Mohedano, A.M., Martín Barriga, M.L., de la Casa Fages, B., Díaz Otero, F., Ezpeleta, D., García Pastor, A., and Gil Núñez, A.

Published
2013
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37. Guidelines for the preventive treatment of ischaemic stroke and TIA (I). Update on risk factors and life style

Author

Fuentes, B., Gállego, J., Gil-Nuñez, A., Morales, A., Purroy, F., Roquer, J., Segura, T., Tejada, J., Lago, A., Díez-Tejedor, E., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Castellanos, M., Castillo, J., Dávalos, A., Díaz-Otero, F., Egido, J.A., López-Fernández, J.C., Freijo, M., García Pastor, A., Gilo, F., Irimia, P., Maestre, J., Masjuan, J., Martí-Fábregas, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Nombela, F., Ribó, M., Rodríguez-Yañez, M., Rubio, F., Serena, J., Simal, P., and Vivancos, J.

Published
2012
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38. Guía para el tratamiento preventivo del ictus isquémico y AIT (I). Actuación sobre los factores de riesgo y estilo de vida

Author

Fuentes, B., Gállego, J., Gil-Nuñez, A., Morales, A., Purroy, F., Roquer, J., Segura, T., Tejada, J., Lago, A., Díez-Tejedor, E., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Castellanos, M., Castillo, J., Dávalos, A., Díaz-Otero, F., Egido, J.A., López-Fernández, J.C., Freijo, M., García Pastor, A., Gilo, F., Irimia, P., Maestre, J., Masjuan, J., Martí-Fábregas, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Nombela, F., Ribó, M., Rodríguez-Yañez, M., Rubio, F., Serena, J., Simal, P., and Vivancos, J.

Published
2012
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44. Detailed experimental validation and benchmarking of six models for longitudinal tensile failure of unidirectional composites

Author

Breite, C., primary, Melnikov, A., additional, Turon, A., additional, de Morais, A.B., additional, Le Bourlot, C., additional, Maire, E., additional, Schöberl, E., additional, Otero, F., additional, Mesquita, F., additional, Sinclair, I., additional, Costa, J., additional, Mayugo, J.A., additional, Guerrero, J.M., additional, Gorbatikh, L., additional, McCartney, L.N., additional, Hajikazemi, M., additional, Mehdikhani, M., additional, Mavrogordato, M.N., additional, Camanho, P.P., additional, Tavares, R., additional, Spearing, S.M., additional, Lomov, S.V., additional, Pimenta, S., additional, Van Paepegem, W., additional, and Swolfs, Y., additional

Published
2022
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45. A synchrotron computed tomography dataset for validation of longitudinal tensile failure models based on fibre break and cluster development

Author

Breite, C., primary, Melnikov, A., additional, Turon, A., additional, de Morais, A.B., additional, Bourlot, C. Le, additional, Maire, E., additional, Schöberl, E., additional, Otero, F., additional, Mesquita, F., additional, Sinclair, I., additional, Costa, J., additional, Mayugo, J.A., additional, Guerrero, J.M., additional, Gorbatikh, L., additional, McCartney, L.N., additional, Hajikazemi, M., additional, Mehdikhani, M., additional, Mavrogordato, M.N., additional, Camanho, P.P., additional, Tavares, R., additional, Spearing, S.M., additional, Lomov, S.V., additional, Pimenta, S., additional, Van Paepegem, W., additional, and Swolfs, Y., additional

Published
2021
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46. A methodology to generate design allowables of composite laminates using machine learning

Author

Furtado, C. (author), Tavares, R. P. (author), Gomes Pereira, L.P. (author), Salgado, M. (author), Otero, F. (author), Catalanotti, G. (author), Arteiro, A. (author), Bessa, M.A. (author), Camanho, P. P. (author), Furtado, C. (author), Tavares, R. P. (author), Gomes Pereira, L.P. (author), Salgado, M. (author), Otero, F. (author), Catalanotti, G. (author), Arteiro, A. (author), Bessa, M.A. (author), and Camanho, P. P. (author)

Abstract

This work represents the first step towards the application of machine learning techniques in the prediction of statistical design allowables of composite laminates. Building on data generated analytically, four machine algorithms (XGBoost, Random Forests, Gaussian Processes and Artificial Neural Networks) are used to predict the notched strength of composite laminates and their statistical distribution, associated to the uncertainty related to the material properties and geometrical features. This work focuses not only on the so-called Legacy Quad Laminates (0°/90°/±45°), typically used in the design of composite aerostructures, but also on the newer concept of double-double (or double-angle ply) laminates. Very good representations of the design space, translating in low generalization relative errors of around ±10%, and very accurate representations of the distributions of notched strengths around single design points and corresponding B-basis allowables are obtained. All machine learning algorithms, with the exception of the Random Forests, show very good performances, with Gaussian Processes outperforming the others for very small number of data points while Artificial Neural Networks have better performance for larger training sets. This work serves as basis for the prediction of first-ply failure, ultimate strength and failure mode of composite specimens based on non-linear finite element simulations, providing further reduction of the computational time required to virtually obtain the design allowables for composite laminates., Team Georgy Filonenko

Published
2021
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47. An efficient multi-scale method for non-linear analysis of composite structures

Author

Otero, F, Martinez, Xavier, Oller, Sergio, Salomon, Rotlisbeger, and Omar, Ramon

Subjects
Engineering, Manufacturing, Engineering, Mechanical, Engineering, Civil, Engineering, Industrial, Engineering, Multidisciplinary, Engineering, Ocean, Computer Science, Software Engineering, Engineering, Aerospace, Engineering, Biomedical, Engineering, Marine
Abstract

The use of multi-scale procedures is encouraged by the continuous increase of computational capacity, but it is still a challenge performing a non-linear analysis of real composite structures without the aid of large computers. This work proposes a strategy to conduct non-linear multi-scale analysis in an efficient way. The proposed method considers that in a large structure, in general, material non-linear processes only take place in a localized region (or in a reduced number of finite elements, if a FE method is used). The strategy determines the elements that require a non-linear analysis defining of a non-linear activation function that accounts for the failure of the most critical point in the microstructure. The procedure conserves the dissipated energy through the scales, being mesh independent as the mesh objectivity concept is extended to the microstructure. The validity of the strategy proposed is proved with the analysis of academic examples showing not only the mesh independency but also the reduction of computational cost. Finally, an industrial composite component is solved using a standard computer, showing that the proposed strategy is capable of reducing the computational cost from 32 days and 14 hours (required by a classical multi-scale method) to less than 12 hours.

Published
2020

48. Characteristics and Outcomes in Patients with COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry

Author

Ntaios, G. Michel, P. Georgiopoulos, G. Guo, Y. Li, W. Xiong, J. Calleja, P. Ostos, F. González-Ortega, G. Fuentes, B. Alonso De Leciñana, M. Díez-Tejedor, E. García-Madrona, S. Masjuan, J. Defelipe, A. Turc, G. Gonçalves, B. Domigo, V. Dan, G.-A. Vezeteu, R. Christensen, H. Christensen, L.M. Meden, P. Hajdarevic, L. Rodriguez-Lopez, A. Díaz-Otero, F. García-Pastor, A. Gil-Nuñez, A. Maslias, E. Strambo, D. Werring, D.J. Chandratheva, A. Benjamin, L. Simister, R. Perry, R. Beyrouti, R. Jabbour, P. Sweid, A. Tjoumakaris, S. Cuadrado-Godia, E. Campello, A.R. Roquer, J. Moreira, T. Mazya, M.V. Bandini, F. Matz, K. Iversen, H.K. González-Duarte, A. Tiu, C. Ferrari, J. Vosko, M.R. Salzer, H.J.F. Lamprecht, B. Dünser, M.W. Cereda, C.W. Quintero, Á.B.C. Korompoki, E. Soriano-Navarro, E. Soto-Ramírez, L.E. Castañeda-Méndez, P.F. Bay-Sansores, D. Arauz, A. Cano-Nigenda, V. Kristoffersen, E.S. Tiainen, M. Strbian, D. Putaala, J. Lip, G.Y.H.

Abstract

Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and can be very efficiently treated with recanalization techniques, confirmation of this putative association is urgently warranted in a large representative patient cohort to alert stroke clinicians, and inform pre- and in-hospital acute stroke patient pathways. We pooled all consecutive patients hospitalized with laboratory-confirmed COVID-19 and acute ischemic stroke in 28 sites from 16 countries. To assess whether stroke severity and outcomes (assessed at discharge or at the latest assessment for those patients still hospitalized) in patients with acute ischemic stroke are different between patients with COVID-19 and non-COVID-19, we performed 1:1 propensity score matching analyses of our COVID-19 patients with non-COVID-19 patients registered in the Acute Stroke Registry and Analysis of Lausanne Registry between 2003 and 2019. Between January 27, 2020, and May 19, 2020, 174 patients (median age 71.2 years; 37.9% females) with COVID-19 and acute ischemic stroke were hospitalized (median of 12 patients per site). The median National Institutes of Health Stroke Scale was 10 (interquartile range [IQR], 4-18). In the 1:1 matched sample of 336 patients with COVID-19 and non-COVID-19, the median National Institutes of Health Stroke Scale was higher in patients with COVID-19 (10 [IQR, 4-18] versus 6 [IQR, 3-14]), P=0.03; (odds ratio, 1.69 [95% CI, 1.08-2.65] for higher National Institutes of Health Stroke Scale score). There were 48 (27.6%) deaths, of which 22 were attributed to COVID-19 and 26 to stroke. Among 96 survivors with available information about disability status, 49 (51%) had severe disability at discharge. In the propensity score-matched population (n=330), patients with COVID-19 had higher risk for severe disability (median mRS 4 [IQR, 2-6] versus 2 [IQR, 1-4], P

Published
2020

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