679 results on '"Oshimura, Mitsuo"'
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2. Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model
3. Co-treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency
4. Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal cancer
5. Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci
6. Panel of human cell lines with human/mouse artificial chromosomes
7. Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism
8. Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling
9. Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
10. Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice
11. Treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency
12. A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein–protein interactions mediated by G protein-coupled receptors
13. Transmission of Genomic Instability from a Single Irradiated Human Chromosome to the Progeny of Unirradiated Cells
14. Complete Absence of Cockayne Syndrome Group B Gene Product Gives Rise to UV-Sensitive Syndrome but Not Cockayne Syndrome
15. Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome
16. DNA-PKcs is Critical for Telomere Capping
17. An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells
18. Double Trans-Chromosomic Mice: Maintenance of Two Individual Human Chromosome Fragments Containing Ig Heavy and κ Loci and Expression of Fully Human Antibodies
19. Loss of Imprinting of a Paternally Expressed Transcript, with Antisense Orientation to K v LQT1, Occurs Frequently in Beckwith-Wiedemann Syndrome and Is Independent of Insulin-Like Growth Factor II Imprinting
20. Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models
21. Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome
22. Highly sensitive luciferase reporter assay using a potent destabilization sequence of calpain 3
23. Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes
24. Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next‐generation human artificial chromosomes for Duchenne muscular dystrophy
25. Development of a High-Sensitivity Quantitation Method for Arginine Vasopressin by High-Performance Liquid Chromatography Tandem Mass Spectrometry, and Comparison with Quantitative Values by Radioimmunoassay
26. An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals
27. Multiple expression cassette exchange via TP901‐1, R4, and Bxb1 integrase systems on a mouse artificial chromosome
28. A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges
29. A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features
30. Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells
31. Additional file 2 of Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal cancer
32. Production of Knockout Mice by Random or Targeted Mutagenesis in Spermatogonial Stem Cells
33. A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site
34. Loss of the Catalytic Subunit of the DNA-Dependent Protein Kinase in DNA Double-Strand-Break-Repair Mutant Mammalian Cells
35. Human Chromosome 11 Contains Two Different Growth Suppressor Genes for Embryonal Rhabdomyosarcoma
36. Induction of Cellular Senescence in Immortalized Cells by Human Chromosome 1
37. The transfer of human artificial chromosomes via cryopreserved microcells
38. SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors
39. Introduction of a CD40L genomic fragment via a human artificial chromosome vector permits cell-type-specific gene expression and induces immunoglobulin secretion
40. Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification
41. Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells
42. Suggestive evidence for chromosomal localization of non-coding RNA from imprinted LIT1
43. Additional file 1 of Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome
44. Exogenous gene expression and growth regulation of hematopoietic cells via a novel human artificial chromosome
45. Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells
46. A novel expression system for genomic DNA loci using a human artificial chromosome vector with transformation-associated recombination cloning
47. Topoisomerase II cleavage activity within the human D11Z1 and DXZ1 alpha-satellite arrays
48. Narrowed abrogation of the Angelman syndrome critical interval on human chromosome 15 does not interfere with epigenotype maintenance in somatic cells
49. Tumor suppressive role of a 2.4 Mb 9q33–q34 critical region and DEC1 in esophageal squamous cell carcinoma
50. A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing
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