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Eccrine hidradenoma (EH) is a rare benign cutaneous neoplasm, believed to arise from the distal excretory duct of the eccrine sweat glands. We report an exceptional lesion of eccrine hidradenoma localized to the breast and clinically mimicking a carcinoma of the breast. Aim: We aim to describe the pathological characteristics of this lesion. We report the case of a 59 year old woman. She presented with a right-sided breast nodule. Physical examination, found a mobile firm nodule retracting the skin. By ultrasound examination, the tumor was heterogeneous and measured 11 mm in great diameter. A local surgical excision of the nodule was performed. By histological exam, the diagnosis of EH was retained. The complement of immunohistochemistry was not requested. This tumor is usually confined to the dermis or subcutaneous layer without. EH of the breast is an uncommon site. Histopathological confirmation is necessary and wide excision of these tumors is the treatment of choice.

Introduction: Non-Hodgkin’s primary lymphoma of the breast is a rare entity. These tumors represent 0.04% to 0.52% of malignant breast pathology, 2.2% of extranodal lymphoma and 0.4% of all non-Hodgkin lymphoma. Clinical and radiological aspects show no special characteristics. The diagnosis is based on the presence of a lymphomatous proliferation strongly associated to the breast tissue and the diagnosis of an extra-mammary lymphoma must be removed except the presence of ipsilateral axillary lymphadenopathy. Patients and methods: This is a retrospective study of 9 patients treated for non-Hodgkin’s primary lymphoma of the breast. They were collected over a period of 14 years (2000-2013). They interested 1 case of follicular lymphoma, 1 case of large T-cell lymphoma and 7 cases of large B-cell lymphoma. The average age was 50 years, ranging from 30 to 76 years. The sex ratio was 0.11 (1 man/8 women). The median follow-up was 43 months (4-192). Six patients were older than 60 years. All the tumors were architecturally diffuse. The overall survival was 100% at one year 60% at 3 years. Seven patients achieved a complete remission after initial treatment; one had relapsed after 2 months. Among the 7 cases of large B cell lymphoma, two cases result from follicular lymphoma’s transformation. The average processing time was 17 months. Conclusion: The primary breast lymphoma is often diagnosed late. Treatment should be rapidly implemented. Indeed, the 5-year survival of stage I of the Ann Arbor classification is better than for stage II.

Objective: Breast carcinoma in men represents 1% of all breast cancers. The micropapillary carcinoma (MPC) of the breast is a morphologically distinctive form accounting for 2.7% of ductual carcinoma in which the tumor cells are arranged in morule-like clusters. A pure MPC of the breast is very rare. This report describes a pure micro papillary carcinoma in a 36-year old man, with clinical, pathological and immunohistochemical features. Methods: We present a case of this rare type of breast cancer diagnosed in a male patient and summarize the current literature to date. The patient presented with a painless mass measuring 1 cm in great diameter adhering to superficial and deep planes. A microbiopsy was performed and the final histopathology revealed a pure MPC of the male breast in more than 50% of tumor’s volume. On immunohistochemical investigations of the specimen, tumor’s cells stained for GCDFP15 and showed high expression of estrogen, progesterone antibodies. We had completed by lumpectomy with axillary dissection which found 14 lymph nodes including 2 metastatic lymph nodes. Results: The MPC differs histologically from conventional papillary carcinoma of the breast, which typically exhibits a complex arborescent growth pattern within cystically dilated duct-line space. A secondary MPC of the breast must be researched as a differential diagnosis of primary MPC, especially micropapillary variant of transitional carcinoma of the bladder and MPC of the lung. Immunohistochemically, the positivity of GCDFP-15 in breast cancers and the positivity of TTF-1 in lung cancers are useful in distinguishing them. Conclusion: MPC is a special subtype of invasive ductal carcinoma with an aggressive nature. Despite the small number of studies, MPC of the breast is undoubtedly not rare. Recognition of this relatively rare entity is important in predicting metastasis to lymph nodes and distant sites regardless of tumor size. Axillary and distant metastasis should be evaluated to determine the therapeutic strategy.

Background: Calcifying fibrous tumor (CFT) is a rare benign mesenchymal tumor; with a predilection for children and young adults that usually arises in the subcutaneous and deep soft tissues, pleura, or peritoneum. CFT of the gastrointestinal tract is exceedingly rare. Discussion: We describe here a patient with an unusual presentation-intestinal calcifying fibrous tumor. This 26-year-old man came to our emergency department with abdominal distension and intermittent epigastric cramping pain. The physical examination was negative. Colonoscopy showed an intestinal polyp, measuring 3 cm in greatest axe. The macroscopic examination showed a segmental resection of jejunum with pedunculated polyp. The polyp had a smooth, shiny and gray surface, it measured 3 cm. Histologically, it was consisting of hyalinized, hypocellular lamellar collagen, bland spindle cells, chronic inflammatory cell infiltrates, and psammomatous or dystrophic calcifications. Conclusion: CFT of the gastrointestinal tract is exceedingly rare. We describe a case arising in the small intestine, and discuss the differential diagnosis with other common and uncommon spindle cell lesions.