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7. Anaphylaxis after vaccination for cats in Japan

Author

YOSHIDA, Megumi, primary, MIZUKAMI, Keijiro, additional, HISASUE, Masaharu, additional, IMANISHI, Ichiro, additional, KURATA, Keigo, additional, OCHIAI, Masaki, additional, ITOH, Masato, additional, NASUKAWA, Tadahiro, additional, UCHIYAMA, Jumpei, additional, TSUJIMOTO, Hajime, additional, and SAKAGUCHI, Masahiro, additional

Published
2021
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8. Anaphylaxis after rabies vaccination for dogs in Japan

Author

YOSHIDA, Megumi, primary, MIZUKAMI, Keijiro, additional, HISASUE, Masaharu, additional, IMANISHI, Ichiro, additional, KURATA, Keigo, additional, OCHIAI, Masaki, additional, ITOH, Masato, additional, NASUKAWA, Tadahiro, additional, UCHIYAMA, Jumpei, additional, TSUJIMOTO, Hajime, additional, and SAKAGUCHI, Masahiro, additional

Published
2021
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10. The 2nd Meeting of National Control Laboratories for Vaccines and Biologicals in the Western Pacific

Author

Oh, Hokyung, primary, Shin, Jinho, additional, Lee, Chung Keel, additional, Ochiai, Masaki, additional, Nojima, Kiyoko, additional, Lim, Chang Kweng, additional, Raut, Sanj, additional, Lisovsky, Irene, additional, Williams, Stella, additional, Yoo, Ki Young, additional, Shin, Dong-Yeop, additional, Ato, Manabu, additional, Ye, Qiang, additional, Han, Kiwon, additional, Lee, Chulhyun, additional, Lee, Naery, additional, Hong, Ji Young, additional, Jung, Kikyung, additional, Van Hung, Pham, additional, and Jeong, Jayoung, additional

Published
2018
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11. The First Meeting of the National Control Laboratories for Vaccines and Biologicals in the Western Pacific in 2016

Author

Oh, Hokyung, primary, Shin, Jinho, additional, Ato, Manabu, additional, Ma, Xiao, additional, Williams, David, additional, Han, Kiwon, additional, Kim, Yang Jin, additional, Kang, Hyunggoo, additional, Jung, Kikyung, additional, Hanada, Kentaro, additional, Ochiai, Masaki, additional, Hung, Pham Van, additional, Park, Sangmi, additional, and Ahn, Chiyoung, additional

Published
2017
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13. Standardization of Quantitative PCR for Human T-Cell Leukemia Virus Type 1 in Japan: a Collaborative Study

Author

Kuramitsu, Madoka, primary, Okuma, Kazu, additional, Yamochi, Tadanori, additional, Sato, Tomoo, additional, Sasaki, Daisuke, additional, Hasegawa, Hiroo, additional, Umeki, Kazumi, additional, Kubota, Ryuji, additional, Sobata, Rieko, additional, Matsumoto, Chieko, additional, Kaneko, Noriaki, additional, Naruse, Isao, additional, Yamagishi, Makoto, additional, Nakashima, Makoto, additional, Momose, Haruka, additional, Araki, Kumiko, additional, Mizukami, Takuo, additional, Mizusawa, Saeko, additional, Okada, Yoshiaki, additional, Ochiai, Masaki, additional, Utsunomiya, Atae, additional, Koh, Ki-Ryang, additional, Ogata, Masao, additional, Nosaka, Kisato, additional, Uchimaru, Kaoru, additional, Iwanaga, Masako, additional, Sagara, Yasuko, additional, Yamano, Yoshihisa, additional, Satake, Masahiro, additional, Okayama, Akihiko, additional, Mochizuki, Manabu, additional, Izumo, Shuji, additional, Saito, Shigeru, additional, Itabashi, Kazuo, additional, Kamihira, Shimeru, additional, Yamaguchi, Kazunari, additional, Watanabe, Toshiki, additional, and Hamaguchi, Isao, additional

Published
2015
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14. A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis

Author

Momose, Haruka, Mizukami, Takuo, Ochiai, Masaki, Hamaguchi, Isao, and Yamaguchi, Kazunari

Subjects
Article Subject
Abstract

For the past 50 years, quality control and safety tests have been used to evaluate vaccine safety. However, conventional animal safety tests need to be improved in several aspects. For example, the number of test animals used needs to be reduced and the test period shortened. It is, therefore, necessary to develop a new vaccine evaluation system. In this review, we show that gene expression patterns are well correlated to biological responses in vaccinated rats. Our findings and methods using experimental biology and genome science provide an important means of assessment for vaccine toxicity.

Published
2010
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15. Investigation in a murine model of possible mechanisms of enhanced local reactions to post-primary diphtheria-tetanus toxoid boosters in recipients of acellular pertussis-diphtheria-tetanus vaccine

Author

Ochiai, Masaki, primary, Horiuchi, Yoshinobu, additional, Yuen, Chun-Ting, additional, Asokanathan, Catpagavalli, additional, Yamamoto, Akihiko, additional, Okada, Kenji, additional, Kataoka, Michiyo, additional, Markey, Kevin, additional, Corbel, Michael, additional, and Xing, Dorothy, additional

Published
2014
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18. Anaphylaxis after vaccination for cats in Japan.

Author

Yoshida M, Mizukami K, Hisasue M, Imanishi I, Kurata K, Ochiai M, Itoh M, Nasukawa T, Uchiyama J, Tsujimoto H, and Sakaguchi M

Subjects
Animals, Cats, Culture Media, Japan, Vaccination adverse effects, Vaccination veterinary, Anaphylaxis etiology, Anaphylaxis veterinary, Cat Diseases
Abstract

Severe adverse reactions in cats after vaccination were examined from 316 cases reported to the Ministry of Agriculture, Forestry and Fisheries (MAFF) in Japan during 15-year period from April 2004 to March 2019. We found that 130 (41%) showed anaphylaxis, and 99 (76%) of the 130 cases of anaphylaxis resulted in death. Veterinarians should be well prepared to deal with vaccine-associated anaphylaxis in cats. Bovine serum albumin (BSA) as indicator of purification was detected at high levels in commercially available feline vaccines. BSA might derive from fetal calf serum in culture media. This study provides useful information about anaphylaxis including critical details of the potential clinical signs associated with adverse events to feline vaccination.

Published
2022
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19. Endotoxin content in Haemophilus influenzae type b vaccine.

Author

Ochiai M, Kataoka M, Toyoizumi H, Yamamoto A, Kamachi K, Arakawa Y, Kurata T, and Horiuchi Y

Subjects
Animals, Child, Endotoxins toxicity, Humans, Infant, Limulus Test, Rabbits, Vaccination, Endotoxins analysis, Haemophilus Vaccines chemistry, Haemophilus influenzae type b immunology, Tetanus Toxoid chemistry, Vaccines, Conjugate chemistry
Abstract

Haemophilus influenzae type b (Hib) is a major cause of bacterial meningitis among children. Hib conjugate vaccines have effectively prevented Hib infection, and routine immunization with Hib conjugate vaccine has diminished the incidence of the disease in the United States and European countries. Introduction of Hib conjugate vaccines is also required in Japan. However, endotoxin that can carry over from Gram-negative H. influenzae with a purified component may contribute to adverse events following Hib vaccination. In the present study, we examined the endotoxin content in Hib conjugate vaccines. The Hib conjugate vaccine batches, which were produced by a European vaccine manufacturer, were shown to have considerably high endotoxin activity and to vary from 13.9 to 173.7 endotoxin units/dose. These results suggest that it is necessary to monitor the endotoxin content of the vaccine batches to ensure the quality and safety of the vaccines.

Published
2004

20. A cell line assay system for predicting the response of human blood to endotoxin.

Author

Yamamoto A, Sakai T, Ochiai M, Kamachi K, Kataoka M, Toyoizumi H, and Horiuchi Y

Subjects
Animals, Cell Line, Dose-Response Relationship, Drug, Drug Synergism, Female, Fever chemically induced, Humans, Interferons pharmacology, Interleukin-6 biosynthesis, Rabbits, Tumor Necrosis Factor-alpha biosynthesis, Blood Cells drug effects, Endotoxins toxicity
Abstract

Some parenteral drugs augment the in vivo action of endotoxin. It is necessary to regulate the overall toxic action of contaminating endotoxin by developing a clinically relevant test method for the safety control of such drugs. Although the responses of human peripheral blood cells (hPBC) to endotoxins to produce tumour necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and IL-1beta showed considerable variation depending on the endotoxin and also on the individuals used as sources of blood, the responses to each of the endotoxins evaluated relative to that to the Japanese reference standard endotoxin were found to be highly reproducible irrespective of the sources of hPBC. The evaluation procedure based on the relative responsiveness to various endotoxins was shown to be highly effective to detect differences in responsiveness among the endotoxin test, the pyrogen test, and the cytokine induction in hPBC. When eight human monocytoid cell lines were examined, only THP-1 and 28SC cells showed a significant dose-dependent IL-6 production. However, THP-1 failed to show consistency with hPBC in responses to the panel of endotoxins. 28SC cells showed appropriate consistency with hPBC not only in terms of respective responses to the endotoxins but also with regard to detection of the effect of human interferons to augment endotoxin to induce IL-6.

Published
2003

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