26,078 results on '"O'Malley AS"'
Search Results
2. Co-Educational Residential Life: Evaluation of a Pilot Program
- Author
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Christi Mackey, Lori O’Malley, Sonya Munsell, and Mark Hickey
- Abstract
This study utilized a qualitative approach to learn about a co-educational housing pilot program in a rural serving, four-year regional university in the mid-south United States. Four individuals involved in the program took part in semi-structured interviews. Open coding analysis revealed four themes: sense of belonging, learning, gender and sexuality, and secrets.
- Published
- 2024
3. Monitoring the Future National Survey Results on Drug Use, 1975-2023: Overview and Detailed Results for Secondary School Students
- Author
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University of Michigan, Institute for Social Research, Richard A. Miech, Lloyd D. Johnston, Megan E. Patrick, Patrick M. O'Malley, and Jerald G. Bachman
- Abstract
Monitoring the Future (MTF) is designed to give such attention to substance use among the nation's youth and adults. It is an investigator-initiated study that originated with, and is conducted by, a team of research professors at the University of Michigan's Institute for Social Research. Since its onset in 1975, MTF has been funded continuously by the National Institute on Drug Abuse--one of the National Institutes of Health--under a series of peer reviewed, competitive research grants. This 2023 survey is the 49th consecutive national survey of 12th grade students and the 33rd national survey of 8th and 10th grade students (who were added to the study in 1991). MTF contains ongoing national surveys of both adolescents and adults in the United States. It provides the nation with a vital window into the important but often hidden problem behaviors of use of illegal drugs, alcohol, tobacco, and psychotherapeutic drugs used without a doctor's orders. Two of the major topics included in the present monograph are: (1) the prevalence and frequency of use of a great many substances, both licit and illicit, among U.S. secondary school students in 8th, 10th, and 12th grades; and (2) historical trends in use by students in those grades. Distinctions are made among important demographic subgroups in these populations based on gender, college plans, region of the country, population density, parent education, and race/ethnicity. MTF has demonstrated that key attitudes and beliefs about drug use are important determinants of usage trends, in particular the amount of risk to the user perceived to be associated with the various drugs and disapproval of using them; thus, those measures also are tracked over time, as are students' perceptions of certain relevant aspects of the social environment--in particular, perceived availability of each drug, peer norms about their use, and use by friends. Data on grade of first use, noncontinuation of use, trends in use in lower grades (based on retrospective reports), and intensity of use are also reported. [For "Monitoring the Future National Survey Results on Drug Use, 1975-2022: Secondary School Students," see ED627366.]
- Published
- 2024
4. Embracing Fairness in Consumer Electricity Markets using an Automatic Market Maker
- Author
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Sweeney, Shaun, King, Chris, O'Malley, Mark, and Shorten, Robert
- Subjects
Electrical Engineering and Systems Science - Systems and Control ,Computer Science - Computer Science and Game Theory - Abstract
As consumer flexibility becomes expected, it is important that the market mechanisms which attain that flexibility are perceived as fair. We set out fairness issues in energy markets today, and propose a market design to address them. Consumption is categorised as either essential or flexible with different prices and reliability levels for each. Prices are generated by an Automatic Market Maker (AMM) based on instantaneous scarcity and resource is allocated using a novel Fair Play algorithm. We empirically show the performance of the system over 1 year for 101 UK households and benchmark its performance against more classical approaches., Comment: Under review for inclusion in Special Issue of Applied Energy on `(R)Evolution of Electricity Markets: Designing Smart Electricity Markets for a Decarbonized World'
- Published
- 2024
5. Enhancing Code Translation in Language Models with Few-Shot Learning via Retrieval-Augmented Generation
- Author
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Bhattarai, Manish, Santos, Javier E., Jones, Shawn, Biswas, Ayan, Alexandrov, Boian, and O'Malley, Daniel
- Subjects
Computer Science - Artificial Intelligence ,Computer Science - Software Engineering - Abstract
The advent of large language models (LLMs) has significantly advanced the field of code translation, enabling automated translation between programming languages. However, these models often struggle with complex translation tasks due to inadequate contextual understanding. This paper introduces a novel approach that enhances code translation through Few-Shot Learning, augmented with retrieval-based techniques. By leveraging a repository of existing code translations, we dynamically retrieve the most relevant examples to guide the model in translating new code segments. Our method, based on Retrieval-Augmented Generation (RAG), substantially improves translation quality by providing contextual examples from which the model can learn in real-time. We selected RAG over traditional fine-tuning methods due to its ability to utilize existing codebases or a locally stored corpus of code, which allows for dynamic adaptation to diverse translation tasks without extensive retraining. Extensive experiments on diverse datasets with open LLM models such as Starcoder, Llama3-70B Instruct, CodeLlama-34B Instruct, Granite-34B Code Instruct, and Mixtral-8x22B, as well as commercial LLM models like GPT-3.5 Turbo and GPT-4o, demonstrate our approach's superiority over traditional zero-shot methods, especially in translating between Fortran and CPP. We also explored varying numbers of shots i.e. examples provided during inference, specifically 1, 2, and 3 shots and different embedding models for RAG, including Nomic-Embed, Starencoder, and CodeBERT, to assess the robustness and effectiveness of our approach., Comment: LLM for code translation
- Published
- 2024
6. Travel time and energy dissipation minima in heterogeneous subsurface flows
- Author
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Hansen, Scott K. and O'Malley, Daniel
- Subjects
Physics - Fluid Dynamics ,Mathematical Physics ,Physics - Geophysics - Abstract
We establish a number of results concerning conditions for minimum energy dissipation and advective travel time in porous and fractured media. First, we establish a pair of converse results concerning fluid motion along a streamline between two points of fixed head: the minimal advective time is achieved under conditions of constant energy dissipation, and minimal energy dissipation is achieved under conditions of constant velocity along the streamline (implying homogeneous conductivity in the vicinity of the streamline). We also show directly by means of variational methods that minimum advection time along a streamline with a given average conductivity is achieved when the conductivity is constant. Finally, we turn our attention to minimum advection time and energy dissipation in parallel and sequential fracture systems governed by the cubic law: for which fracture cross-section and conductivity are intimately linked. We show that, as in porous domains, flow partitioning between different pathways always acts to minimize system energy dissipation. Finally, we consider minimum advection time as a function of aperture distribution in a sequence of fracture segments. We show that, for a fixed average aperture, a uniform-aperture system displays the shortest advection time. However, we also show that any sufficiently small small perturbations in aperture away from uniformity always act to reduce advection time.
- Published
- 2024
7. Information Extraction from Historical Well Records Using A Large Language Model
- Author
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Ma, Zhiwei, Santo, Javier E., Lackey, Greg, Viswanathan, Hari, and O'Malley, Daniel
- Subjects
Computer Science - Information Retrieval - Abstract
To reduce environmental risks and impacts from orphaned wells (abandoned oil and gas wells), it is essential to first locate and then plug these wells. Although some historical documents are available, they are often unstructured, not cleaned, and outdated. Additionally, they vary widely by state and type. Manual reading and digitizing this information from historical documents are not feasible, given the high number of wells. Here, we propose a new computational approach for rapidly and cost-effectively locating these wells. Specifically, we leverage the advanced capabilities of large language models (LLMs) to extract vital information including well location and depth from historical records of orphaned wells. In this paper, we present an information extraction workflow based on open-source Llama 2 models and test them on a dataset of 160 well documents. Our results show that the developed workflow achieves excellent accuracy in extracting location and depth from clean, PDF-based reports, with a 100% accuracy rate. However, it struggles with unstructured image-based well records, where accuracy drops to 70%. The workflow provides significant benefits over manual human digitization, including reduced labor and increased automation. In general, more detailed prompting leads to improved information extraction, and those LLMs with more parameters typically perform better. We provided a detailed discussion of the current challenges and the corresponding opportunities/approaches to address them. Additionally, a vast amount of geoscientific information is locked up in old documents, and this work demonstrates that recent breakthroughs in LLMs enable us to unlock this information more broadly.
- Published
- 2024
8. Demographic Subgroup Trends among Adolescents in the Use of Various Licit and Illicit Drugs, 1975-2022. Monitoring the Future Occasional Paper Series. Paper 99
- Author
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University of Michigan, Institute for Social Research, Johnston, Lloyd D., Miech, Richard A., Patrick, Megan E., O'Malley, Patrick M., Bachman, Jerald G., and Schulenberg, John E.
- Abstract
This occasional paper presents national demographic subgroup data for the 1975-2022 Monitoring the Future (MTF) national survey results on 8th, 10th, and 12th graders' use of drugs, alcohol, and tobacco. The study covers all major classes of illicit and licit psychoactive drugs for an array of population subgroups. The 2020 subgroup data presented in this report accompany the "Monitoring the Future National Survey Results on Drug Use: 1975-2022: Overview, Key Findings on Adolescent Drug Use" (ED627365) and the "Monitoring the Future National Survey Results on Drug Use, 1975-2022: Secondary School Students" (ED627366). The trends shown in both tabular and graphic forms in this report cover demographic subgroups based on: (1) Gender; (2) College plans; (3) Region of the country; (4) Population density; (5) Education level of the parents (a proxy for socioeconomic level); and (6) Racial/ethnic identification.
- Published
- 2023
9. Monitoring the Future National Survey Results on Drug Use, 1975-2022: Secondary School Students
- Author
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University of Michigan, Institute for Social Research, Miech, Richard A., Johnston, Lloyd D., Patrick, Megan E., O'Malley, Patrick M., Bachman, Jerald G., and Schulenberg, John E.
- Abstract
Monitoring the Future (MTF) is designed to give such attention to substance use among the nation's youth and adults. It is an investigator-initiated study that originated with, and is conducted by, a team of research professors at the University of Michigan's Institute for Social Research. Since its onset in 1975, MTF has been funded continuously by the National Institute on Drug Abuse--one of the National Institutes of Health--under a series of peer reviewed, competitive research grants. The 2022 survey, reported here, is the 48th consecutive national survey of 12th grade students and the 32nd national survey of 8th and 10th grade students (who were added to the study in 1991). MTF contains ongoing national surveys of both adolescents and adults in the United States. It provides the nation with a vital window into the important but often hidden problem behaviors of use of illegal drugs, alcohol, tobacco, and psychotherapeutic drugs (used without a doctor's orders). For more than four decades, MTF has helped provide a clearer view of the changing topography of these problems among adolescents and adults, a better understanding of the dynamics of factors that drive some of these problems, and a better understanding of some of their consequences. It has also given policymakers, government agencies, and nongovernmental organizations (NGOs) in the field some practical approaches for intervening. Two of the major topics included in the present monograph are: (1) the prevalence and frequency of use of a great many substances, both licit and illicit, among U.S. secondary school students in 8th, 10th, and 12th grades; and (2) historical trends in use by students in those grades. Distinctions are made among important demographic subgroups in these populations based on gender, college plans, region of the country, population density, parent education, and race/ethnicity. MTF has demonstrated that key attitudes and beliefs about drug use are important determinants of usage trends, in particular the amount of risk to the user perceived to be associated with the various drugs and disapproval of using them; thus, those measures also are tracked over time, as are students' perceptions of certain relevant aspects of the social environment--in particular, perceived availability of each drug, peer norms about their use, use by friends, and exposure to use by others of the various drugs. Data on grade of first use, noncontinuation of use, trends in use in lower grades (based on retrospective reports), and intensity of use are also reported here. [For "Monitoring the Future National Survey Results on Drug Use, 1975-2021. Volume I, Secondary School Students," see ED619855.]
- Published
- 2023
10. Older Adults’ Use of Cannabis and Attitudes Around Disclosing Medical Cannabis Use to Their Healthcare Providers in California: A Mixed Methods Study
- Author
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Abu Baker, Dania, Cruz Rivera, Paola N., Narasimhan, Rekha, Nguyen, Nhi, Tibiriçá, Lize, Kepner, Wayne E., O’Malley, Pearse, Nguyen, Annie L., and Moore, Alison A.
- Published
- 2024
- Full Text
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11. Spatial co-transcriptomics reveals discrete stages of the arbuscular mycorrhizal symbiosis
- Author
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Serrano, Karen, Bezrutczyk, Margaret, Goudeau, Danielle, Dao, Thai, O’Malley, Ronan, Malmstrom, Rex R, Visel, Axel, Scheller, Henrik V, and Cole, Benjamin
- Subjects
Microbiology ,Plant Biology ,Biological Sciences ,Ecology ,Genetics ,Human Genome ,1.1 Normal biological development and functioning ,Zero Hunger ,Crop and Pasture Production ,Plant biology - Abstract
The symbiotic interaction of plants with arbuscular mycorrhizal (AM) fungi is ancient and widespread. Plants provide AM fungi with carbon in exchange for nutrients and water, making this interaction a prime target for crop improvement. However, plant-fungal interactions are restricted to a small subset of root cells, precluding the application of most conventional functional genomic techniques to study the molecular bases of these interactions. Here we used single-nucleus and spatial RNA sequencing to explore both Medicago truncatula and Rhizophagus irregularis transcriptomes in AM symbiosis at cellular and spatial resolution. Integrated, spatially registered single-cell maps revealed infected and uninfected plant root cell types. We observed that cortex cells exhibit distinct transcriptome profiles during different stages of colonization by AM fungi, indicating dynamic interplay between both organisms during establishment of the cellular interface enabling successful symbiosis. Our study provides insight into a symbiotic relationship of major agricultural and environmental importance and demonstrates a paradigm combining single-cell and spatial transcriptomics for the analysis of complex organismal interactions.
- Published
- 2024
12. Hierarchical Multigrid Ansatz for Variational Quantum Algorithms
- Author
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Keller, Christo Meriwether, Eidenbenz, Stephan, Bärtschi, Andreas, O'Malley, Daniel, Golden, John, and Misra, Satyajayant
- Subjects
Quantum Physics ,Computer Science - Emerging Technologies - Abstract
Quantum computing is an emerging topic in engineering that promises to enhance supercomputing using fundamental physics. In the near term, the best candidate algorithms for achieving this advantage are variational quantum algorithms (VQAs). We design and numerically evaluate a novel ansatz for VQAs, focusing in particular on the variational quantum eigensolver (VQE). As our ansatz is inspired by classical multigrid hierarchy methods, we call it "multigrid" ansatz. The multigrid ansatz creates a parameterized quantum circuit for a quantum problem on $n$ qubits by successively building and optimizing circuits for smaller qubit counts $j < n$, reusing optimized parameter values as initial solutions to next level hierarchy at $j+1$. We show through numerical simulation that the multigrid ansatz outperforms the standard hardware-efficient ansatz in terms of solution quality for the Laplacian eigensolver as well as for a large class of combinatorial optimization problems with specific examples for MaxCut and Maximum $k$-Satisfiability. Our studies establish the multi-grid ansatz as a viable candidate for many VQAs and in particular present a promising alternative to the QAOA approach for combinatorial optimization problems., Comment: 11 pages, 9 figures
- Published
- 2023
- Full Text
- View/download PDF
13. Learning the Factors Controlling Mineralization for Geologic Carbon Sequestration
- Author
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Pachalieva, Aleksandra, Hyman, Jeffrey D., O'Malley, Daniel, Viswanathan, Hari, and Srinivasan, Gowri
- Subjects
Computer Science - Computational Engineering, Finance, and Science ,Computer Science - Machine Learning ,Physics - Geophysics - Abstract
We perform a set of flow and reactive transport simulations within three-dimensional fracture networks to learn the factors controlling mineral reactions. CO$_2$ mineralization requires CO$_2$-laden water, dissolution of a mineral that then leads to precipitation of a CO$_2$-bearing mineral. Our discrete fracture networks (DFN) are partially filled with quartz that gradually dissolves until it reaches a quasi-steady state. At the end of the simulation, we measure the quartz remaining in each fracture within the domain. We observe that a small backbone of fracture exists, where the quartz is fully dissolved which leads to increased flow and transport. However, depending on the DFN topology and the rate of dissolution, we observe a large variability of these changes, which indicates an interplay between the fracture network structure and the impact of geochemical dissolution. In this work, we developed a machine learning framework to extract the important features that support mineralization in the form of dissolution. In addition, we use structural and topological features of the fracture network to predict the remaining quartz volume in quasi-steady state conditions. As a first step to characterizing carbon mineralization, we study dissolution with this framework. We studied a variety of reaction and fracture parameters and their impact on the dissolution of quartz in fracture networks. We found that the dissolution reaction rate constant of quartz and the distance to the flowing backbone in the fracture network are the two most important features that control the amount of quartz left in the system. For the first time, we use a combination of a finite-volume reservoir model and graph-based approach to study reactive transport in a complex fracture network to determine the key features that control dissolution., Comment: 23 pages, 5 figures, 2 tables
- Published
- 2023
14. Reconstruction of Fields from Sparse Sensing: Differentiable Sensor Placement Enhances Generalization
- Author
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Marcato, Agnese, O'Malley, Daniel, Viswanathan, Hari, Guiltinan, Eric, and Santos, Javier E.
- Subjects
Physics - Geophysics ,Computer Science - Machine Learning - Abstract
Recreating complex, high-dimensional global fields from limited data points is a grand challenge across various scientific and industrial domains. Given the prohibitive costs of specialized sensors and the frequent inaccessibility of certain regions of the domain, achieving full field coverage is typically not feasible. Therefore, the development of algorithms that intelligently improve sensor placement is of significant value. In this study, we introduce a general approach that employs differentiable programming to exploit sensor placement within the training of a neural network model in order to improve field reconstruction. We evaluated our method using two distinct datasets; the results show that our approach improved test scores. Ultimately, our method of differentiable placement strategies has the potential to significantly increase data collection efficiency, enable more thorough area coverage, and reduce redundancy in sensor deployment.
- Published
- 2023
15. JuliQAOA: Fast, Flexible QAOA Simulation
- Author
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Golden, John, Bärtschi, Andreas, O'Malley, Daniel, Pelofske, Elijah, and Eidenbenz, Stephan
- Subjects
Quantum Physics - Abstract
We introduce JuliQAOA, a simulation package specifically built for the Quantum Alternating Operator Ansatz (QAOA). JuliQAOA does not require a circuit-level description of QAOA problems, or another package to simulate such circuits, instead relying on a more direct linear algebra implementation. This allows for increased QAOA-specific performance improvements, as well as improved flexibility and generality. JuliQAOA is the first QAOA package designed to aid in the study of both constrained and unconstrained combinatorial optimization problems, and can easily include novel cost functions, mixer Hamiltonians, and other variations. JuliQAOA also includes robust and extensible methods for learning optimal angles. Written in the Julia language, JuliQAOA outperforms existing QAOA software packages and scales well to HPC-level resources. JuliQAOA is available at https://github.com/lanl/JuliQAOA.jl.
- Published
- 2023
- Full Text
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16. Monitoring the Future Panel Study Annual Report: National Data on Substance Use among Adults Ages 19 to 60, 1976-2022
- Author
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University of Michigan, Institute for Social Research, Patrick, Megan E., Miech, Richard A., Johnston, Lloyd D., and O'Malley, Patrick M.
- Abstract
Monitoring the Future (MTF) is an ongoing research program conducted at the University of Michigan's Institute for Social Research under a series of investigator-initiated, competing research grants from the National Institute on Drug Abuse beginning in 1975. The integrated MTF study includes annual surveys of nationally representative samples of 8th, 10th, and 12th grade students, as well as a subset of 12th grade students followed into adulthood from each graduating class. Repeating these annual cross-sectional surveys over time provides data to examine behavior change across history in consistent age segments of the adult population, as well as among key subgroups. The panel study now has over 110,000 individuals, with approximately 28,500 surveyed each year including young adults ages 19 to 30 and midlife adults ages 35 to 60. These data, gathered on national samples over such a large portion of the lifespan, are extremely rare and can provide needed insight into the epidemiology, etiology, and life course history of substance use and relevant behaviors, attitudes, and other factors. The current report is the latest in a series of publications dating back to 1986 and updated annually since then, all available at monitoringthefuture.org. [For the previous report, "Monitoring the Future Panel Study Annual Report: National Data on Substance Use among Adults Ages 19 to 60, 1976-2021," see ED623992.]
- Published
- 2023
17. Monitoring the Future National Survey Results on Drug Use, 1975-2022: Overview, Key Findings on Adolescent Drug Use
- Author
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University of Michigan, Institute for Social Research, Johnston, Lloyd D., Miech, Richard A., Patrick, Megan E., O'Malley, Patrick M., Schulenberg, John E., and Bachman, Jerald G.
- Abstract
Monitoring the Future (MTF) has become one of the nation's most relied upon scientific sources of valid information on trends in use of licit and illicit psychoactive drugs by U.S. adolescents, college students, young adults, and adults up to age 60. During the last four decades, the study has tracked and reported on the use of an ever-growing array of such substances in these populations of adolescents and adults. The annual MTF series of monographs is one of the primary mechanisms through which the new epidemiological findings are reported. Findings from the inception of the study in 1975 through 2022 are included--the results of 48 national in-school surveys and 46 national follow up surveys. MTF has conducted in-school surveys of nationally representative samples of: (1) 12th grade students each year since 1975; and (2) 8th and 10th grade students each year since 1991. In addition, beginning with the class of 1976, the study has conducted follow up surveys of representative subsamples of the respondents from each previously participating 12th grade class. These follow up surveys now continue well into adulthood, currently up to age 60. MTF is designed to detect age, period, and cohort effects in substance use and related attitudes. Age effects are similar changes at similar ages seen across multiple class cohorts; they are common during adolescence. Period effects are changes that are parallel over a number of years across multiple age groups (in this case, all three grades under study--8, 10, and 12). Cohort effects are substance use behaviors or attitudes that distinguish a class cohort from others that came before or after them and are maintained as the cohort ages. The survey results divide cleanly into the time periods before and after the onset of the COVID-19 pandemic. All surveys in 2020 were completed before March 15, when data collection was halted due to pandemic concerns. Consequently, results from 2020 and previous years are pre-pandemic, while results from 2021 and 2022 took place after the onset of the pandemic and the associated national response. [For "Monitoring the Future National Survey Results on Drug Use, 1975-2021: Overview, Key Findings on Adolescent Drug Use," see ED618240.]
- Published
- 2023
18. The Histo-Kitchen: Using Food Items to Teach Histology
- Author
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Stewart, Andrew and O'Malley, Chasity B.
- Abstract
Engaging students in active learning has proved to transform reflexive knowledge into true learning of material in medical education. Histology is one subject area that consistently presents as a challenge for medical and undergraduate students. The large amount of complex information needed to completely understand and interpret histological images is something that is many medical students do not fully grasp in the pre-clinical stages. Pedagogical studies that use physical objects and hands on learning have been shown to motivate and encourage students to self-learn such complex topics. This application of using physical objects and hands on learning, however, is not the easiest to translate to the cellular level. The Histo-Kitchen was designed to help students manage the vast amount of information and acquire knowledge in a meaningful and creative way. By incorporating food items into an active learning session, students were able to stretch their imagination and find representative items for common histological specimen representations. Based on post-session discussions, students found the activity to be beneficial to their learning and greatly enjoyed participating in the activity, often citing it as the most fun they have had learning histology. By providing students with opportunities to interact with complex material in creative and novel ways, students are able to learn in an environment that can be both engaging and enjoyable.
- Published
- 2023
19. How Delivery Method Impacts Student Perceptions of Anxiety and Learning with Combined Muddiest Point and Peer Instruction Activities in Community College Anatomy & Physiology Classes: Lessons for Faculty, Higher Education Academic Leaders, and Educational Technology Leaders
- Author
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Anthony C. Edwards, Suzanne Hood, Murray Jensen, Ron Gerrits, Melaney Farr, and Chasity O'Malley
- Abstract
Muddiest point and peer instruction are evidence-based instructional practices that can be used to address student learning gaps. The purpose of this study was to determine the impact of modality (face to face or online) on student perceptions of the effectiveness of combined muddiest point and peer instruction activities in community college anatomy and physiology courses. Data was collected through end of course surveys and included quantitative and qualitative results. While there was no significant difference in student perception of anxiety or contribution to learning among face-to-face and online students, anxiety levels were low and contribution to learning was high for both groups. Both groups generally provided positive qualitative responses, but online students were more likely to provide positive feedback on muddiest point and peer instruction activities than face-to-face students. Negative responses tended to focus on wanting to work alone and dissatisfaction with classmates' contributions. This study was supported as part of the Community College Anatomy and Physiology Education Research (CAPER) project (2111119). https://doi.org/10.21692/haps.2023.023
- Published
- 2023
20. What Makes Communities of Practice Persist? Lessons from Anatomy and Physiology Instructors Communities of Practice
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Audrey Rose Hyson, Chasity B. O'Malley, Kamie K. Stack, Megan C. Deutschman, Megan Bernier, and Murray Jensen
- Abstract
While there has been a recent focus on developing programs to support educational research by community college anatomy and physiology instructors, there is not yet an established long-term community of practice (CoPs) in this particular area. Studies of long-term CoPs, particularly in STEM education, are few and far between. This study examines College in the Schools (CIS), a long-term community of practice for high school anatomy and physiology (A&P) educators in Minnesota and Wisconsin. In addition, this study highlights the factors that attract high school A&P teachers to CIS and the possibility of creating a similar CoP for community college (CC) A&P instructors focused on educational research. It was discovered that despite their varying reasons for joining, members of CIS and CC instructors tend to participate in CoPs similarly. As a result, A&P instructors from CC who are interested in educational research could benefit from a CoP structure similar to CIS over a longer period of time.
- Published
- 2023
21. The 24α27Mg(24α27,p)24α27Al reaction measurement using solenoid spectrometer for nuclear astrophysics (SSNAP)
- Author
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Gu, G. M., Chae, K. Y., Cha, S. M., Kwag, M. S., Kim, M. J., Allen, J., O’Malley, P. D., Boeltzig, A., Clark, A. M., Frentz, B., Kolk, B. V., Blankstein, D., Bardayan, D. W., Wilkinson, J., Seymour, G., Howard, K. B., Renaud, M., Hall, M. R., deBoer, R. J., Huestis, P., Kelmar, R., Aguilar, S., and Henderson, S. L.
- Published
- 2024
- Full Text
- View/download PDF
22. Evolutionary Strategies Enable Systematic and Reliable Uncertainty Quantification: A Proof-of-Concept Pilot Study on Resting-State Functional MRI Language Lateralization
- Author
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Stember, Joseph N., Dishner, Katharine, Jenabi, Mehrnaz, Pasquini, Luca, K Peck, Kyung, Saha, Atin, Shah, Akash, O’Malley, Bernard, Ilica, Ahmet Turan, Kelly, Lori, Arevalo-Perez, Julio, Hatzoglou, Vaios, Holodny, Andrei, and Shalu, Hrithwik
- Published
- 2024
- Full Text
- View/download PDF
23. House B by Kart Projects
- Author
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O'Malley-Welby, Gracie
- Published
- 2024
24. The Beta-decay Paul Trap Mk IV: Design and commissioning
- Author
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Varriano, L., Savard, G., Clark, J. A., Burdette, D. P., Burkey, M. T., Gallant, A. T., Hirsh, T. Y., Longfellow, B., Scielzo, N. D., Segel, R., Boron III, E. J., Brodeur, M., Callahan, N., Cannon, A., Kolos, K., Liu, B., Lopez-Caceres, S., Gott, M., Maaß, B., Marley, S. T., Mohs, C., Morgan, G. E., Mueller, P., Oberling, M., O'Malley, P. D., Porter, W. S., Purcell, Z., Ray, D., Rivero, F., Valverde, A. A., Wilson, G. L., and Zite, R.
- Subjects
Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
The Beta-decay Paul Trap is an open-geometry, linear trap used to measure the decays of $^8$Li and $^8$B to search for a tensor contribution to the weak interaction. In the latest $^8$Li measurement of Burkey et al. (2022), $\beta$ scattering was the dominant experimental systematic uncertainty. The Beta-decay Paul Trap Mk IV reduces the prevalence of $\beta$ scattering by a factor of 4 through a redesigned electrode geometry and the use of glassy carbon and graphite as electrode materials. The trap has been constructed and successfully commissioned with $^8$Li in a new data campaign that collected 2.6 million triple coincidence events, an increase in statistics by 30% with 4 times less $\beta$ scattering compared to the previous $^8$Li data set., Comment: 17 pages, 7 figures
- Published
- 2023
- Full Text
- View/download PDF
25. Learning a General Model of Single Phase Flow in Complex 3D Porous Media
- Author
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Santos, Javier E., Marcato, Agnese, Kang, Qinjun, Mehana, Mohamed, O'Malley, Daniel, Viswanathan, Hari, and Lubbers, Nicholas
- Subjects
Physics - Geophysics - Abstract
Modeling effective transport properties of 3D porous media, such as permeability, at multiple scales is challenging as a result of the combined complexity of the pore structures and fluid physics - in particular, confinement effects which vary across the nanoscale to the microscale. While numerical simulation is possible, the computational cost is prohibitive for realistic domains, which are large and complex. Although machine learning models have been proposed to circumvent simulation, none so far has simultaneously accounted for heterogeneous 3D structures, fluid confinement effects, and multiple simulation resolutions. By utilizing numerous computer science techniques to improve the scalability of training, we have for the first time developed a general flow model that accounts for the pore-structure and corresponding physical phenomena at scales from Angstrom to the micrometer. Using synthetic computational domains for training, our machine learning model exhibits strong performance (R$^2$=0.9) when tested on extremely diverse real domains at multiple scales.
- Published
- 2023
26. Computationally Efficient and Error Aware Surrogate Construction for Numerical Solutions of Subsurface Flow Through Porous Media
- Author
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Sorokin, Aleksei G., Pachalieva, Aleksandra, O'Malley, Daniel, Hyman, James M., Hickernell, Fred J., and Hengartner, Nicolas W.
- Subjects
Statistics - Computation ,Mathematics - Numerical Analysis - Abstract
Limiting the injection rate to restrict the pressure below a threshold at a critical location can be an important goal of simulations that model the subsurface pressure between injection and extraction wells. The pressure is approximated by the solution of Darcy's partial differential equation (PDE) for a given permeability field. The subsurface permeability is modeled as a random field since it is known only up to statistical properties. This induces uncertainty in the computed pressure. Solving the PDE for an ensemble of random permeability simulations enables estimating a probability distribution for the pressure at the critical location. These simulations are computationally expensive, and practitioners often need rapid online guidance for real-time pressure management. An ensemble of numerical PDE solutions is used to construct a Gaussian process regression model that can quickly predict the pressure at the critical location as a function of the extraction rate and permeability realization. Our first novel contribution is to identify a sampling methodology for the random environment and matching kernel technology for which fitting the Gaussian process regression model scales as O(n log n) instead of the typical O(n^3) rate in the number of samples n used to fit the surrogate. The surrogate model allows almost instantaneous predictions for the pressure at the critical location as a function of the extraction rate and permeability realization. Our second contribution is a novel algorithm to calibrate the uncertainty in the surrogate model to the discrepancy between the true pressure solution of Darcy's equation and the numerical solution. Although our method is derived for building a surrogate for the solution of Darcy's equation with a random permeability field, the framework broadly applies to solutions of other PDE with random coefficients., Comment: 20 pages, 8 figures, 1 table
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- 2023
27. Progressive reduced order modeling: empowering data-driven modeling with selective knowledge transfer
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Kadeethum, Teeratorn, O'Malley, Daniel, Choi, Youngsoo, Viswanathan, Hari S., and Yoon, Hongkyu
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computational Engineering, Finance, and Science - Abstract
Data-driven modeling can suffer from a constant demand for data, leading to reduced accuracy and impractical for engineering applications due to the high cost and scarcity of information. To address this challenge, we propose a progressive reduced order modeling framework that minimizes data cravings and enhances data-driven modeling's practicality. Our approach selectively transfers knowledge from previously trained models through gates, similar to how humans selectively use valuable knowledge while ignoring unuseful information. By filtering relevant information from previous models, we can create a surrogate model with minimal turnaround time and a smaller training set that can still achieve high accuracy. We have tested our framework in several cases, including transport in porous media, gravity-driven flow, and finite deformation in hyperelastic materials. Our results illustrate that retaining information from previous models and utilizing a valuable portion of that knowledge can significantly improve the accuracy of the current model. We have demonstrated the importance of progressive knowledge transfer and its impact on model accuracy with reduced training samples. For instance, our framework with four parent models outperforms the no-parent counterpart trained on data nine times larger. Our research unlocks data-driven modeling's potential for practical engineering applications by mitigating the data scarcity issue. Our proposed framework is a significant step toward more efficient and cost-effective data-driven modeling, fostering advancements across various fields.
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- 2023
28. Addressing Quantum's 'Fine Print': State Preparation and Information Extraction for Quantum Algorithms and Geologic Fracture Networks
- Author
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Henderson, Jessie M., Kath, John, Golden, John K., Percus, Allon G., and O'Malley, Daniel
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Quantum Physics - Abstract
Quantum algorithms provide an exponential speedup for solving certain classes of linear systems, including those that model geologic fracture flow. However, this revolutionary gain in efficiency does not come without difficulty. Quantum algorithms require that problems satisfy not only algorithm-specific constraints, but also application-specific ones. Otherwise, the quantum advantage carefully attained through algorithmic ingenuity can be entirely negated. Previous work addressing quantum algorithms for geologic fracture flow has illustrated core algorithmic approaches while incrementally removing assumptions. This work addresses two further requirements for solving geologic fracture flow systems with quantum algorithms: efficient system state preparation and efficient information extraction. Our approach to addressing each is consistent with an overall exponential speed-up., Comment: 13 pages, 12 figures, LA-UR-23-31328
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- 2023
29. Structure Studies of $^{13}\text{Be}$ from the $^{12}$Be(d,p) reaction in inverse kinematics on a solid deuteron target
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Kovoor, J., Jones, K. L., Hooker, J., Vostinar, M., Kanungo, R., Pain, S. D., Alcorta, M., Allen, J., Andreoiu, C., Atar, L., Bardayan, D. W., Bhattacharjee, S. S., Blankstein, D., Burbadge, C., Burcher, S., Catford, W. N., Cha, S., Chae, K., Connolly, D., Davids, B., Esker, N. E., Garcia, F. H., Gillespie, S., Ghimire, R., Gula, A., Hackman, G., Hallam, S., Hellmich, M., Henderson, J., Holl, M., Jassal, P., King, S., Knight, T., Kruecken, R., Lepailleur, A., Liang, J., Morrison, L., O'Malley, P. D., Pereira-Lopez, X., Psaltis, A., Radich, A., Refsgaard, J., Shotter, A. C., Williams, M., and Workman, O.
- Subjects
Nuclear Experiment - Abstract
The low-lying structure of $^{13}$Be has remained an enigma for decades. Despite numerous experimental and theoretical studies, large inconsistencies remain. Being both unbound, and one neutron away from $^{14}$Be, the heaviest bound beryllium nucleus, $^{13}$Be is difficult to study through simple reactions with weak radioactive ion beams or more complex reactions with stable-ion beams. Here, we present the results of a study using the $^{12}$Be(d,p)$^{13}$Be reaction in inverse kinematics using a 9.5~MeV per nucleon $^{12}$Be beam from the ISAC-II facility. The solid deuteron target of IRIS was used to achieve an increased areal thickness compared to conventional deuterated polyethylene targets. The Q-value spectrum below -4.4~MeV was analyzed using a Bayesian method with GEANT4 simulations. A three-point angular distribution with the same Q-value gate was fit with a mixture of $s$- and $p$-wave, $s$- and $d$-wave, or pure $p$-wave transfer. The Q-value spectrum was also compared with GEANT simulations obtained using the energies and widths of states reported in four previous works. It was found that our results are incompatible with works that revealed a wide $5/2^+$ resonance but shows better agreement with ones that reported a narrower width., Comment: 10 pages, 5 figures
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- 2023
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30. Grand challenges of wind energy science – meeting the needs and services of the power system
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M. O'Malley, H. Holttinen, N. Cutululis, T. K. Vrana, J. King, V. Gevorgian, X. Wang, F. Rajaei-Najafabadi, and A. Hadjileonidas
- Subjects
Renewable energy sources ,TJ807-830 - Abstract
The share of wind power in power systems is increasing dramatically, and this is happening in parallel with increased penetration of solar photovoltaics, storage, other inverter-based technologies, and electrification of other sectors. Recognising the fundamental objective of power systems, maintaining supply–demand balance reliably at the lowest cost, and integrating all these technologies are significant research challenges that are driving radical changes to planning and operations of power systems globally. In this changing environment, wind power can maximise its long-term value to the power system by balancing the needs it imposes on the power system with its contribution to addressing these needs with services. A needs and services paradigm is adopted here to highlight these research challenges, which should also be guided by a balanced approach, concentrating on its advantages over competitors. The research challenges within the wind technology itself are many and varied, with control and coordination internally being a focal point in parallel with a strong recommendation for a holistic approach targeted at where wind has an advantage over its competitors and in coordination with research into other technologies such as storage, power electronics, and power systems.
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- 2024
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31. Estimating the impact of physician risky-prescribing on the network structure underlying physician shared-patient relationships
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Xin Ran, Ellen Meara, Nancy E. Morden, Erika L. Moen, Daniel N. Rockmore, and A. James O’Malley
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Risky prescribing ,Shared-patient physician network ,Homophily ,Deprescribing ,Quantifying polypharmacy ,State-space ,Applied mathematics. Quantitative methods ,T57-57.97 - Abstract
Abstract Social network analysis and shared-patient physician networks have become effective ways of studying physician collaborations. Assortative mixing or “homophily” is the network phenomenon whereby the propensity for similar individuals to form ties is greater than for dissimilar individuals. Motivated by the public health concern of risky-prescribing among older patients in the United States, we develop network models and tests involving novel network measures to study whether there is evidence of homophily in prescribing and deprescribing in the specific shared-patient network of physicians linked to the US state of Ohio in 2014. Evidence of homophily in risky-prescribing would imply that prescribing behaviors help shape physician networks and would suggest strategies for interventions seeking to reduce risky-prescribing (e.g., strategies to directly reduce risky prescribing might be most effective if applied as group interventions to risky prescribing physicians connected through the network and the connections between these physicians could be targeted by tie dissolution interventions as an indirect way of reducing risky prescribing). Furthermore, if such effects varied depending on the structural features of a physician’s position in the network (e.g., by whether or not they are involved in cliques—groups of actors that are fully connected to each other—such as closed triangles in the case of three actors), this would further strengthen the case for targeting groups of physicians involved in risky prescribing and the network connections between them for interventions. Using accompanying Medicare Part D data, we converted patient longitudinal prescription receipts into novel measures of the intensity of each physician’s risky-prescribing. Exponential random graph models were used to simultaneously estimate the importance of homophily in prescribing and deprescribing in the network beyond the characteristics of physician specialty (or other metadata) and network-derived features. In addition, novel network measures were introduced to allow homophily to be characterized in relation to specific triadic (three-actor) structural configurations in the network with associated non-parametric randomization tests to evaluate their statistical significance in the network against the null hypothesis of no such phenomena. We found physician homophily in prescribing and deprescribing. We also found that physicians exhibited within-triad homophily in risky-prescribing, with the prevalence of homophilic triads significantly higher than expected by chance absent homophily. These results may explain why communities of prescribers emerge and evolve, helping to justify group-level prescriber interventions. The methodology may be applied, adapted or generalized to study homophily and its generalizations on other network and attribute combinations involving analogous shared-patient networks and more generally using other kinds of network data underlying other kinds of social phenomena.
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- 2024
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32. Aerial imagery dataset of lost oil wells
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Anastasiia Kim, Teeratorn Kadeethum, Christine Downs, Hari S. Viswanathan, and Daniel O’Malley
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Science - Abstract
Abstract Orphaned wells are wells for which the operator is unknown or insolvent. The location of hundreds of thousands of these wells remain unknown in the United States alone. Cost-effective techniques are essential to locate orphaned wells to address environmental problems. In this paper, we present a dataset consisting of 120,948 aerial images of recently documented orphan wells. Each of these 512 × 512 images is paired with segmentation masks that indicate the presence or absence of such well. These images, sourced from the National Agriculture Imagery Program, cover the continental United States with spatial resolutions ranging from 30 centimeters to 1 meter. Additionally, we included negative examples by selecting locations uniformly across the United States. Accompanying metadata includes the IDs and spatial resolution of the original images, which are available for free through the United States Geological Survey, and the pixel coordinates of documented orphaned wells identified in these images. This dataset is intended to support the development of deep-learning models that can help locating undocumented orphan wells from such imagery, thereby blunting the environmental damage they do.
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- 2024
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33. Continuous adaptation of conversation aids for uterine fibroids treatment options in a four-year multi-center implementation project
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Danielle Schubbe, Marie-Anne Durand, Rachel C. Forcino, Jaclyn Engel, Marisa Tomaino, Monica Adams-Foster, Carla Bacon, Carrie Cahill Mulligan, Sateria Venable, Tina Foster, Paul J. Barr, Raymond M. Anchan, Shannon Laughlin-Tommaso, Anne Lindholm, Maya Seshan, Rossella M. Gargiulo, Patricia Stephenson, Karen George, Mobolaji Ajao, Tessa Madden, Erika Banks, Antonio R. Gargiulo, James O’Malley, Maria van den Muijsenbergh, Johanna W. M. Aarts, and Glyn Elwyn
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Uterine fibroids ,Shared decision making ,Implementation ,User-centered design ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background Fibroids are non-cancerous uterine growths that can cause symptoms impacting quality of life. The breadth of treatment options allows for patient-centered preference. While conversation aids are known to facilitate shared decision making, the implementation of these aids for uterine fibroids treatments is limited. We aimed to develop two end-user-acceptable uterine fibroids conversation aids for an implementation project. Our second aim was to outline the adaptations that were made to the conversation aids as implementation occurred. Methods We used a multi-phase user-centered participatory approach to develop a text-based and picture-enhanced conversation aid for uterine fibroids. We conducted a focus group with project stakeholders and user-testing interviews with eligible individuals with symptomatic uterine fibroids. We analyzed the results of the user-testing interviews using Morville’s Honeycomb framework. Spanish translations of the conversation aids occurred in parallel with the English iterations. We documented the continuous adaptations of the conversation aids that occurred during the project using an expanded framework for reporting adaptations and modifications to evidence-based interventions (FRAME). Results The first iteration of the conversation aids was developed in December 2018. Focus group participants (n = 6) appreciated the brevity of the tools and suggested changes to the bar graphs and illustrations used in the picture-enhanced version. User-testing with interview participants (n = 9) found that both conversation aids were satisfactory, with minor changes suggested. However, during implementation, significant changes were suggested by patients, other stakeholders, and participating clinicians when they reviewed the content. The most significant changes required the addition or deletion of information about treatment options as newer research was published or as novel interventions were introduced into clinical practice. Conclusions This multi-year project revealed the necessity of continuously adapting the uterine fibroids conversation aids so they remain acceptable in an implementation and sustainability context. Therefore, it is important to seek regular user feedback and plan for the need to undertake updates and revisions to conversation aids if they are going to be acceptable for clinical use.
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- 2024
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34. Osteogenesis Imperfecta: A study of the patient journey in 13 European countries
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Ingunn Westerheim, Valerie Cormier-Daire, Scott Gilbert, Sean O’Malley, and Richard Keen
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Medicine - Abstract
Abstract Introduction Osteogenesis imperfecta (OI) is a heritable skeletal disorder and comprises various subtypes that differ in clinical presentation, with Type I considered the least severe and Types III/IV the most severe forms. The study aim was to understand the OI patient diagnostic and treatment journey across Europe. Methods We conducted a qualitative, descriptive study to understand the OI patient journey. A selection of people with OI/their caregivers and clinicians involved in OI-patient care from across Europe were interviewed using a specially developed questionnaire. Results Between May 2022 and July 2022, 22 people with OI/caregivers and 22 clinicians (endocrinologists, orthopaedic surgeons, geneticists and metabolic specialists) from across Europe were interviewed. Our study showed various areas of concerns for the OI community. Timely diagnosis of OI is essential; misdiagnoses and a delay to treatment initiation are all too common. There are a lack of consensus guidelines regarding optimal treatments (including when bisphosphonate therapy should be initiated and the route of administration) and patient management throughout the duration of the patient’s life. Adult OI patients do not have a medical home and are often managed by endocrinologists and rheumatologists. Adult care is often reactive based on the development of new symptoms. The psychosocial burden of OI impacts on the patient’s quality of life. Conclusions There is an urgent need for increased awareness about OI and its wide range of symptoms. In particular, there is a need for consensus guidelines outlining the optimum care throughout the duration of the OI patient’s life.
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- 2024
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35. Exercise‐induced pain within endurance exercise settings: Definitions, measurement, mechanisms and potential interventions
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Callum A. O'Malley, Samuel A. Smith, Alexis R. Mauger, and Ryan Norbury
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aetiology ,definitions ,interventions ,mechanisms ,nociception ,pain ,Physiology ,QP1-981 - Abstract
Abstract Pain can be defined as an unpleasant sensory and emotional experience associated with or resembling that associated with actual or potential tissue damage. Though consistent with this definition, different types of pain result in different behavioural and psychophysiological responses. For example, the transient, non‐threatening, acute muscle pain element of exercise‐induced pain (EIP) is entirely different from other pain types like delayed onset muscle soreness, muscular injury or chronic pain. However, studies often conflate the definitions or assume parity between distinct pain types. Consequently, the mechanisms through which pain might impact exercise behaviour across different pain subcategories may be incorrectly assumed, which could lead to interventions or recommendations that are inappropriate. Therefore, this review aims to distinguish EIP from other subcategories of pain according to their aetiologies and characteristics, thereby providing an updated conceptual and operational definition of EIP. Secondly, the review will discuss the experimental pain models currently used across several research domains and their relevance to EIP with a focus on the neuro‐psychophysiological mechanisms of EIP and its effect on exercise behaviour and performance. Finally, the review will examine potential interventions to cope with the impact of EIP and support wider exercise benefits. Highlights What is the topic of this review? Considerations for future research focusing on exercise‐induced pain within endurance exercise settings. What advances does it highlight? An updated appraisal and guide of research concerning exercise‐induced pain and its impact on endurance task behaviour, particularly with reference to the aetiology, measurement, and manipulation of exercise‐induced pain.
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- 2024
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36. Vernier Microcombs for Integrated Optical Atomic Clocks
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Wu, Kaiyi, O'Malley, Nathan P., Fatema, Saleha, Wang, Cong, Girardi, Marcello, Alshaykh, Mohammed S., Ye, Zhichao, Leaird, Daniel E., Qi, Minghao, Torres-Company, Victor, and Weiner, Andrew M.
- Subjects
Physics - Optics - Abstract
CMOS-compatible Kerr microcombs have drawn substantial interest as mass-manufacturable, compact alternatives to bulk frequency combs. This could enable deployment of many comb-reliant applications previously confined to laboratories. Particularly enticing is the prospect of microcombs performing optical frequency division in compact optical atomic clocks. Unfortunately, it is difficult to meet the self-referencing requirement of microcombs in these systems due to the $\sim$THz repetition rates typically required for octave-spanning comb generation. Additionally, it is challenging to spectrally engineer a microcomb system to align a comb mode with an atomic clock transition with sufficient signal-to-noise ratio. Here, we adopt a Vernier dual-microcomb scheme for optical frequency division of a stabilized ultranarrow-linewidth continuous-wave laser at 871 nm to a $\sim$235 MHz output frequency. In addition to enabling measurement of the comb repetition rates, this scheme brings the freedom to pick comb lines from either or both of the combs. We exploit this flexibility to shift an ultra-high-frequency ($\sim$100 GHz) carrier-envelope offset beat down to frequencies where detection is possible and to place a comb line close to the 871 nm laser - tuned so that if frequency-doubled it would fall close to the clock transition in $^{171}$Yb$^+$. Moreover, we introduce a novel scheme which suppresses frequency noise arising from interferometric phase fluctuations in our dual-comb system and reduces the frequency instability down to our measurement limit. Our dual-comb system can potentially combine with an integrated ion trap toward future chip-scale optical atomic clocks.
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- 2023
37. Characterizing the impacts of multi-scale heterogeneity on solute transport in fracture networks
- Author
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Sweeney, Matthew R., Hyman, Jeffrey D., O'Malley, Daniel, Santos, Javier E., Carey, J. William, Stauffer, Philip H., and Viswanathan, Hari S.
- Subjects
Physics - Geophysics - Abstract
We model flow and transport in three-dimensional fracture networks with varying degrees of fracture-to-fracture aperture/permeability heterogeneity and network density to show how changes in these properties can cause the emergence of anomalous flow and transport behavior. If fracture-to-fracture aperture heterogeneity is increased in sparse networks, velocity fluctuations can inhibit high flow rates and solute transport can be delayed, even in cases where hydraulic aperture is monotonically increased. As the density of the networks is increased, more connected pathways allow for particles to bypass these effects. We discover transition behavior where with relatively few connected pathways in a network from inflow to outflow boundaries, the first arrival times of particles are not heavily affected by fracture-to-fracture aperture heterogeneity, but the scaling behavior of the tails is strongly influenced due to the particles being forced to sample some of the heterogeneity in the velocity field caused by aperture differences. These results reinforce the importance of considering multi-scale effects in fractured systems and can inform flow and transport processes in both natural and engineered fracture systems, especially the latter where high aperture fractures are often stimulated and connect to existing fracture networks with smaller apertures.
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- 2023
38. Monitoring the Future National Survey Results on Drug Use, 1975-2021: Volume 1, Secondary School Students
- Author
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University of Michigan, Institute for Social Research, Miech, Richard A., Johnston, Lloyd D., O'Malley, Patrick M., Bachman, Jerald G., Schulenberg, John E., and Patrick, Megan E.
- Abstract
Monitoring the Future (MTF) is designed to give attention to substance use among the nation's youth and adults. It is an investigator-initiated study that originated with, and is conducted by, a team of research professors at the University of Michigan's Institute for Social Research. Since its onset in 1975, MTF has been funded continuously by the National Institute on Drug Abuse--one of the National Institutes of Health--under a series of peer reviewed, competitive research grants. The 2021 survey, reported here, is the 47th consecutive survey of 12th grade students and the 31st such survey of 8th and 10th graders (who were added to the study in 1991). MTF contains ongoing national surveys of both adolescents and adults in the United States. It provides the nation with a vital window into the important but often hidden problem behaviors of use of illegal drugs, alcohol, tobacco, and psychotherapeutic drugs (used without a doctor's orders). For more than four decades, MTF has helped provide a clearer view of the changing topography of these problems among adolescents and adults, a better understanding of the dynamics of factors that drive some of these problems, and a better understanding of some of their consequences. It has also given policymakers, government agencies, and nongovernmental organizations (NGOs) in the field some practical approaches for intervening. Two of the major topics included in the present volume are: (1) the "prevalence and frequency" of use of a great many substances, both licit and illicit, among U.S. secondary school students in 8th, 10th, and 12th grades; and (2) "historical trends" in use by students in those grades. Distinctions are made among important demographic subgroups in these populations based on gender, college plans, region of the country, population density, parent education, and race/ethnicity. MTF has demonstrated that key attitudes and beliefs about drug use are important determinants of usage trends, in particular the amount of risk to the user perceived to be associated with the various drugs and disapproval of using them; thus, those measures also are tracked over time, as are students' perceptions of certain relevant aspects of the social environment--in particular, perceived availability, peer norms, use by friends, and exposure to use by others of the various drugs. Data on grade of first use, discontinuation of use, trends in use in lower grades, and intensity of use are also reported here. [For "Monitoring the Future National Survey Results on Drug Use, 1975-2020. Volume I, Secondary School Students," see ED615087.]
- Published
- 2022
39. Expression and characterization of spore coat CotH kinases from the cellulosomes of anaerobic fungi (Neocallimastigomycetes)
- Author
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Lillington, Stephen P, Hamilton, Matthew, Cheng, Jan-Fang, Yoshikuni, Yasuo, and O'Malley, Michelle A
- Subjects
Microbiology ,Biochemistry and Cell Biology ,Biological Sciences ,Generic health relevance ,Cellulosomes ,Escherichia coli ,Anaerobiosis ,Bacterial Proteins ,Spores ,Adenosine Triphosphate ,Fungi ,Anaerobic fungi ,Cellulosome ,Dockerin ,Protein kinase ,Spore coat CotH ,Other Biological Sciences ,Biochemistry & Molecular Biology ,Biochemistry and cell biology - Abstract
Anaerobic fungi (Neocallimastigomycetes) found in the guts of herbivores are biomass deconstruction specialists with a remarkable ability to extract sugars from recalcitrant plant material. Anaerobic fungi, as well as many species of anaerobic bacteria, deploy multi-enzyme complexes called cellulosomes, which modularly tether together hydrolytic enzymes, to accelerate biomass hydrolysis. While the majority of genomically encoded cellulosomal genes in Neocallimastigomycetes are biomass degrading enzymes, the second largest family of cellulosomal genes encode spore coat CotH domains, whose contribution to fungal cellulosome and/or cellular function is unknown. Structural bioinformatics of CotH proteins from the anaerobic fungus Piromyces finnis shows anaerobic fungal CotH domains conserve key ATP and Mg2+ binding motifs from bacterial Bacillus CotH proteins known to act as protein kinases. Experimental characterization further demonstrates ATP hydrolysis activity in the presence and absence of substrate from two cellulosomal P. finnis CotH proteins when recombinantly produced in E. coli. These results present foundational evidence for CotH activity in anaerobic fungi and provide a path towards elucidating the functional contribution of this protein family to fungal cellulosome assembly and activity.
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- 2023
40. A Review of Explanations for the Boom
- Author
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O’Malley, Eoin, Deng, Kent, Series Editor, and O'Malley, Eoin
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- 2024
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41. Foreign-Owned Companies
- Author
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O’Malley, Eoin, Deng, Kent, Series Editor, and O'Malley, Eoin
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- 2024
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42. Irish Indigenous Companies
- Author
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O’Malley, Eoin, Deng, Kent, Series Editor, and O'Malley, Eoin
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- 2024
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43. Conclusion
- Author
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O’Malley, Eoin, Deng, Kent, Series Editor, and O'Malley, Eoin
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- 2024
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44. Before the Boom: The Historical Background
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O’Malley, Eoin, Deng, Kent, Series Editor, and O'Malley, Eoin
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- 2024
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45. The End of the Boom
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O’Malley, Eoin, Deng, Kent, Series Editor, and O'Malley, Eoin
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- 2024
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46. Sectoral Growth and Export Earnings
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O’Malley, Eoin, Deng, Kent, Series Editor, and O'Malley, Eoin
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- 2024
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47. Introduction
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O’Malley, Eoin, Deng, Kent, Series Editor, and O'Malley, Eoin
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- 2024
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48. Increases in the incremental exercise mean response time across the steady state domain: Implications for exercise testing & prescription
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Bridgette G.J. O'Malley, Robert A. Robergs, and Todd A. Astorino
- Subjects
Mean response time (MRT) ,Incremental exercise ,Steady state (SS) ,Exercise testing ,Exercise prescription ,Medicine (General) ,R5-920 - Abstract
We hypothesized that slowed oxygen uptake (V˙O2) kinetics for exercise transitions to higher power outputs (PO) within the steady state (SS) domain would increase the mean response time (MRT) with increasing exercise intensity during incremental exercise. Fourteen highly trained cyclists (mean ± standard deviation [SD]; age (39 ± 6) years [yr]; and V˙O2 peak = (61 ± 9) mL/kg/min performed a maximal, ramp incremental cycling test and on separate days, four 6-min bouts of cycling at 30%, 45%, 65% & 75% of their incremental peak PO (Wpeak). SS trial data were used to calculate the MRT and verified by mono-exponential and linear curve fitting. When the ramp protocol attained the value from SS, the PO, in Watts (W), was converted to time (min) based on the ramp function W to quantify the incremental MRT (iMRT). Slope analyses for the V˙O2 responses of the SS versus incremental exercise data below the gas exchange threshold (GET) revealed a significant difference (p = 0.003; [0.437 ± 0.08] vs. [0.382 ± 0.05] L⋅min−1). There was a significant difference between the 45% Wpeak steady state V˙O2 (ss V˙O2) ([3.08 ± 0.30] L⋅min−1, respectively), and 30% Wpeak ss V˙O2 (2.26 ± 0.24) (p
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- 2024
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49. Estimating the impact of physician risky-prescribing on the network structure underlying physician shared-patient relationships
- Author
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Ran, Xin, Meara, Ellen, Morden, Nancy E., Moen, Erika L., Rockmore, Daniel N., and O’Malley, A. James
- Published
- 2024
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50. Continuous adaptation of conversation aids for uterine fibroids treatment options in a four-year multi-center implementation project
- Author
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Schubbe, Danielle, Durand, Marie-Anne, Forcino, Rachel C., Engel, Jaclyn, Tomaino, Marisa, Adams-Foster, Monica, Bacon, Carla, Mulligan, Carrie Cahill, Venable, Sateria, Foster, Tina, Barr, Paul J., Anchan, Raymond M., Laughlin-Tommaso, Shannon, Lindholm, Anne, Seshan, Maya, Gargiulo, Rossella M., Stephenson, Patricia, George, Karen, Ajao, Mobolaji, Madden, Tessa, Banks, Erika, Gargiulo, Antonio R., O’Malley, James, van den Muijsenbergh, Maria, Aarts, Johanna W. M., and Elwyn, Glyn
- Published
- 2024
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- View/download PDF
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