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1. NEUROSURGICAL TREATMENTS

Author

Nanney, A. D., primary, Adel, J. G., additional, Smith, T. R., additional, Chandler, J. P., additional, Kimmell, K. T., additional, Walter, K., additional, Zacharia, B. E., additional, Deibert, C., additional, Malone, H. R., additional, Sonabend, A. M., additional, Neugut, A. I., additional, Spencer, B., additional, Bruce, J. N., additional, Wang, Y., additional, Li, S., additional, Zhang, Z., additional, Chen, X., additional, You, G., additional, Yang, P., additional, Yan, W., additional, Bao, Z., additional, Yao, K., additional, Liu, Y., additional, Wang, L., additional, Jiang, T., additional, Farhoud, M. K., additional, Ruge, M. I., additional, Brandes, A. A., additional, Ermani, M., additional, Fioravanti, A., additional, Andreoli, A., additional, Pozzati, E., additional, Bacci, A., additional, Bartolini, S., additional, Poggi, R., additional, Crisi, G., additional, Franceschi, E., additional, Recinos, P. F., additional, Grabowski, M. M., additional, Nowacki, A. S., additional, Thompson, N., additional, Vogelbaum, M. A., additional, Sun, P., additional, Krueger, D., additional, Liu, Z., additional, Kohrman, M., additional, Dagens, A. B., additional, Rachinger, W., additional, Kunz, M., additional, Eigenbrod, S., additional, Lutz, J., additional, Tonn, J.-C., additional, Kreth, F.-W., additional, Duong, H. T., additional, Chaloner, C., additional, Bordo, G., additional, Eisenberg, A., additional, Rosenthal, K., additional, Sim, M.-S., additional, Boasberg, P., additional, Faries, M. B., additional, Hamid, O., additional, Kelly, D. F., additional, Thon, N., additional, Simon, M., additional, Westphal, M., additional, Schackert, G., additional, Nikkhah, G., additional, Hentschel, B., additional, Pietsch, T., additional, Reifenberger, G., additional, Weller, M., additional, Ironside, S., additional, Perry, J., additional, Tsao, M., additional, Mainprize, T., additional, Keith, J., additional, Laperrierre, N., additional, Paszat, L., additional, Sahgal, A., additional, Hoover, J. M., additional, Nwojo, M., additional, Puffer, R., additional, Parney, I. F., additional, Tanaka, S., additional, Nakada, M., additional, Hayashi, Y., additional, Hamada, J.-i., additional, Lee, I. Y., additional, Ekram, T., additional, Jain, R., additional, Scarpace, L., additional, Omodon, M., additional, Rock, J., additional, Rosenblum, M., additional, Kalkanis, S., additional, Amankulor, N. M., additional, Kim, J.-H., additional, Tabar, V., additional, Peck, K. K., additional, Holodny, A. I., additional, Gutin, P. H., additional, Kim, C.-Y., additional, Kim, Y.-H., additional, Kim, T., additional, Kim, I. K., additional, Kim, J. W., additional, Kim, Y. H., additional, Han, J. H., additional, Park, C.-K., additional, Kim, D. G., additional, Jung, H.-W., additional, Nonaka, M., additional, Bamba, Y., additional, Kanemura, Y., additional, and Nakajima, S., additional

Published
2012
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2. Moyamoya disease in a primarily white, midwestern US population: increased prevalence of autoimmune disease.

Author

Bower RS, Mallory GW, Nwojo M, Kudva YC, Flemming KD, and Meyer FB

Subjects
Adult, Comorbidity, Diabetes Mellitus, Type 1 epidemiology, Female, Humans, Hyperlipidemias epidemiology, Male, Middle Aged, Midwestern United States epidemiology, Midwestern United States ethnology, Moyamoya Disease etiology, Prevalence, Thyroid Diseases epidemiology, Young Adult, Autoimmune Diseases epidemiology, Moyamoya Disease epidemiology, White People ethnology
Abstract

Background and Purpose: Moyamoya disease is an uncommon, cerebrovascular occlusive disease of unknown pathogenesis. Previously described Moyamoya cohorts include predominantly Asian populations or ethnically diverse North American cohorts. To gain further insight into the pathogenesis of moyamoya, we examined clinical characteristics of a primarily white, Midwestern US population, Methods: Retrospective analysis of patients with angiographically confirmed moyamoya disease evaluated at our institution was performed. Prevalence of comorbidities, cerebrovascular risk factors, and autoimmune diseases were compared with the general population., Results: Ninety-four patients with moyamoya were evaluated; 72.3% were female. Ethnic composition was primarily white (85%). A significantly higher prevalence of autoimmune disease was seen, particularly type 1 diabetes mellitus (8.5% versus 0.4% in the general population) and thyroid disease (17.0% versus 8.0% in the institutional general patient population). Hyperlipidemia was also increased (27.7% versus 16.3% in the general population)., Conclusions: This study of a unique, primarily white, Midwestern population of moyamoya patients demonstrates a significantly higher prevalence of autoimmune disease than in the general population. This supports a possible autoimmune component to the pathogenesis of moyamoya disease.

Published
2013
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