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Abstract: In order to utilize renewable energy to meet diverse energy requirements, a new combined cooling, heating and power (CCHP) system is proposed to produce cooling output, heating output and power output simultaneously. This proposed system combines a Brayton cycle and a transcritical CO2 refrigeration cycle with ejector-expansion device, which uses solar energy as the heat source to reduce fossil fuel consumption and alleviate environmental problems. A mathematical model is developed to simulate the new CCHP system with transcritical CO2 driven by solar energy under steady-state conditions, and the thermal efficiency and exergy efficiency are used to evaluate the system performance. The effects of several key thermodynamic parameters on the system performance are examined. The results indicate that increasing turbine inlet pressure and ejector inlet temperature could lower the efficiency of the system, and increasing turbine back pressure and turbine inlet temperature could elevate the efficiency of system. In addition, as ejector back pressure increases, the thermal efficiency of system decreases, but the exergy efficiency increases. [Copyright &y& Elsevier]

N6 methyladenosine (m6A), methylation at the sixth N atom of adenosine, is the most common and abundant modification in mammalian mRNAs and non-coding RNAs. Increasing evidence shows that the alteration of m6A modification level could regulate tumour proliferation, metastasis, self-renewal, and immune infiltration by regulating the related expression of tumour genes. However, the role of m6A modification in colorectal cancer (CRC) drug resistance is unclear. Here, MeRIP-seq and RNA-seq techniques were utilized to obtain mRNA, lncRNA expression, and their methylation profiles in 5-Fluorouracil (5-FU)-resistant colon cancer HCT-15 cells and control cells. In addition, we performed detailed bioinformatics analysis as well as in vitro experiments of lncRNA to explore the function of lncRNA with differential m6A in CRC progression and drug resistance. In this study, we obtained the m6A methylomic landscape of CRC cells and resistance group cells by MeRIP-seq and RNA-seq. We identified 3698 differential m6A peaks, of which 2224 were hypermethylated, and 1474 were hypomethylated. Among the lncRNAs, 60 were hypermethylated, and 38 were hypomethylated. GO and KEGG analysis annotations showed significant enrichment of endocytosis and MAPK signalling pathways. Moreover, knockdown of lncRNA ADIRF-AS1 and AL139035.1 promoted CRC proliferation and invasive metastasis in vitro. lncRNA- mRNA network showed that ADIRF-AS1 and AL139035.1 May play a key role in regulating drug resistance formation. We provide the first m6A methylation profile in 5-FU resistance CRC cells and analyse the functions of differential m6A-modified mRNAs and lncRNAs. Our results indicated that differential m6A RNAs were significantly associated with MAPK signalling and endocytosis after induction of 5-FU resistance. Knockdown of LncRNA ADIRF-AS1 and AL139035.1 promotes CRC progression and might be critical in regulating drug resistance formation.