472 results on '"Nita L"'
Search Results
2. Reconfigurations in brain networks upon awakening from slow wave sleep: Interventions and implications in neural communication
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Cassie J. Hilditch, Kanika Bansal, Ravi Chachad, Lily R. Wong, Nicholas G. Bathurst, Nathan H. Feick, Amanda Santamaria, Nita L. Shattuck, Javier O. Garcia, and Erin E. Flynn-Evans
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
AbstractSleep inertia is the brief period of impaired alertness and performance experienced immediately after waking. Little is known about the neural mechanisms underlying this phenomenon. A better understanding of the neural processes during sleep inertia may offer insight into the awakening process. We observed brain activity every 15 min for 1 hr following abrupt awakening from slow wave sleep during the biological night. Using 32-channel electroencephalography, a network science approach, and a within-subject design, we evaluated power, clustering coefficient, and path length across frequency bands under both a control and a polychromatic short-wavelength-enriched light intervention condition. We found that under control conditions, the awakening brain is typified by an immediate reduction in global theta, alpha, and beta power. Simultaneously, we observed a decrease in the clustering coefficient and an increase in path length within the delta band. Exposure to light immediately after awakening ameliorated changes in clustering. Our results suggest that long-range network communication within the brain is crucial to the awakening process and that the brain may prioritize these long-range connections during this transitional state. Our study highlights a novel neurophysiological signature of the awakening brain and provides a potential mechanism by which light improves performance after waking.
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- 2023
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3. Precision Medicine in Pediatric Oncology
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Vo, Kieuhoa T, Parsons, D Williams, and Seibel, Nita L
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Clinical Trials and Supportive Activities ,Clinical Research ,Pediatric ,Rare Diseases ,Childhood Leukemia ,Pediatric Cancer ,Hematology ,Pediatric Research Initiative ,Good Health and Well Being ,Antineoplastic Agents ,Biomarkers ,Tumor ,Child ,Humans ,Molecular Targeted Therapy ,Neoplasms ,Pharmacogenetics ,Precision Medicine ,Genomic profiling ,Next-generation sequencing ,Pediatric cancer ,Precision medicine ,Targeted therapy ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
Improvements in outcome have been seen in children and adolescents with cancer. Nevertheless, challenges remain in trying to improve the outcomes for all children diagnosed with cancer, particularly in patients with metastatic disease or with cancers that are resistant or recur after standard treatment. Precision medicine trials using individualized tumor molecular profiling for selection of targeted therapies are ongoing in adult malignancies. Similar approaches are being applied to children and adolescents with cancer. This article describes how precision medicine is being applied to pediatric oncology and the unique challenges being faced with these efforts.
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- 2020
4. Teaching an Interdisciplinary Graduate-Level Methods Course in an Openly-Networked Connected Learning Environment: A Glass Half-Full
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Secret, Mary, Bryant, Nita L., and Cummings, Cory R.
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Our paper describes the design and delivery of an online interdisciplinary social science research methods course (ISRM) for graduate students in sociology, education, social work, and public administration. Collaborative activities and learning took place in two types of computer-mediated learning environments: a closed Blackboard course management system and a public facing "openly-networked connected learning" environment designed to facilitate cross-discipline connections, student engagement, and digital fluency. A course formative assessment based on student feedback and instructors' reflections informed the lessons learned about the design and delivery of the course. Our assessment suggests that many of the connected learning goals can be met through the closed course management system rather than through the open platform.
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- 2017
5. A 4 tonne demonstrator for large-scale dual-phase liquid argon time projection chambers
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Aimard, B., Alt, Ch., Asaadi, J., Auger, M., Aushev, V., Autiero, D., Badoi, M. M., Balaceanu, A., Balik, G., Balleyguier, L., Bechetoille, E., Belver, D., Blebea-Apostu, A. M., Bolognesi, S., Bordoni, S., Bourgeois, N., Bourguille, B., Bremer, J., Brown, G., Brunetti, G., Brunetti, L., Caiulo, D., Calin, M., Calvo, E., Campanelli, M., Cankocak, K., Cantini, C., Carlus, B., Cautisanu, B. M., Chalifour, M., Chappuis, A., Charitonidis, N., Chatterjee, A., Chiriacescu, A., Chiu, P., Conforti, S., Cotte, P., Crivelli, P., Cuesta, C., Dawson, J., De Bonis, I., De La Taille, C., Delbart, A., Desforge, D., Di Luise, S., Dimitru, B. S., Doizon, F., Drancourt, C., Duchesneau, D., Dulucq, F., Dumarchez, J., Duval, F., Emery, S., Ereditato, A., Esanu, T., Falcone, A., Fusshoeller, K., Gallego-Ros, A., Galymov, V., Geroy, N., Gendotti, A., Gherghel-Lascu, M., Giganti, C., Gil-Botella, I., Girerd, C., Gomoiu, M. C., Gorodetzky, P., Hamada, E., Hanni, R., Hasegawa, T., Holin, A., Horikawa, S., Ikeno, M., Jimenez, S., Jipa, A., Karolak, M., Karyotakis, Y., Kasai, S., Kasami, K., Kishishita, T., Kreslo, I., Kryn, D., Lastoria, C., Lazanu, I., Lehmann-Miotto, G., Lira, N., Loo, K., Lorca, D., Lutz, P., Lux, T., Maalampi, J., Maire, G., Maki, M., Manenti, L., Margineanu, R. M., Marteau, J., Martin-Chassard, G., Mathez, H., Mazzucato, E., Misitano, G., Mitrica, B., Mladenov, D., Bueno, L. Molina, Martinez, C. Moreno, Mols, J. P., Mosu, T. S., Mug, W., Munteanu, A., Murphy, S., Nakayoshi, K., Narita, S., Navas-Nicolas, D., Negishi, K., Nessi, M., Niculescu-Oglinzanu, M., Nita, L., Noto, F., Noury, A., Onishchuk, Y., Palomares, C., Parvu, M., Patzak, T., Penichot, Y., Pennacchio, E., Periale, L., Pessard, H., Pietropaolo, F., Piret, Y., Popov, B., Pugnere, D., Radics, B., Redondo, D., Regenfus, C., Remoto, A., Resnati, F., Rigaut, Y. A., Ristea, C., Rubbia, A., Saftoiu, A., Sakashita, K., Sanchez, F., Santos, C., Scarpelli, A., Schloesser, C., Lavina, L. Scotto, Sendai, K., Sergiampietri, F., Shahsavarani, S., Shoji, M., Sinclair, J., Soto-Oton, J., Stanca, D. L., Stefan, D., Stroescu, P., Sulej, R., Tanaka, M., Toboaru, V., Tonazzo, A., Tromeur, W., Trzaska, W. H., Uchida, T., Vannucci, F., Vasseur, G., Verdugo, A., Viant, T., Vihonen, S., Vilalte, S., Weber, M., Wu, S., Yu, J., Zambelli, L., and Zito, M.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
A 10 kilo-tonne dual-phase liquid argon TPC is one of the detector options considered for the Deep Underground Neutrino Experiment (DUNE). The detector technology relies on amplification of the ionisation charge in ultra-pure argon vapour and oers several advantages compared to the traditional single-phase liquid argon TPCs. A 4.2 tonne dual-phase liquid argon TPC prototype, the largest of its kind, with an active volume of 3x1x1 $m^3$ has been constructed and operated at CERN. In this paper we describe in detail the experimental setup and detector components as well as report on the operation experience. We also present the first results on the achieved charge amplification, prompt scintillation and electroluminescence detection, and purity of the liquid argon from analyses of a collected sample of cosmic ray muons.
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- 2018
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6. Augmentation of Therapy for Combined Loss of Heterozygosity 1p and 16q in Favorable Histology Wilms Tumor: A Children's Oncology Group AREN0532 and AREN0533 Study Report.
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Dix, David B, Fernandez, Conrad V, Chi, Yueh-Yun, Mullen, Elizabeth A, Geller, James I, Gratias, Eric J, Khanna, Geetika, Kalapurakal, John A, Perlman, Elizabeth J, Seibel, Nita L, Ehrlich, Peter F, Malogolowkin, Marcio, Anderson, James, Gastier-Foster, Julie, Shamberger, Robert C, Kim, Yeonil, Grundy, Paul E, and Dome, Jeffrey S
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Clinical Research ,Cancer ,Pediatric ,Pediatric Cancer ,Rare Diseases ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Adolescent ,Adult ,Biomarkers ,Tumor ,Chromosomes ,Human ,Pair 1 ,Female ,Humans ,Kidney Neoplasms ,Loss of Heterozygosity ,Male ,Progression-Free Survival ,Prospective Studies ,Retrospective Studies ,Wilms Tumor ,Young Adult ,AREN0532 and AREN0533 study committees ,Clinical Sciences ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
PurposeIn National Wilms Tumor Study 5 (NWTS-5), tumor-specific combined loss of heterozygosity of chromosomes 1p and 16q (LOH1p/16q) was associated with adverse outcomes in patients with favorable histology Wilms tumor. The AREN0533/AREN0532 studies assessed whether augmenting therapy improved event-free survival (EFS) for these patients. Patients with stage I/II disease received regimen DD4A (vincristine, dactinomycin and doxorubicin) but no radiation therapy. Patients with stage III/IV disease received regimen M (vincristine, dactinomycin, and doxorubicin alternating with cyclophosphamide and etoposide) and radiation therapy.MethodsPatients were enrolled through the AREN03B2 Biology study between October 2006 and October 2013; all underwent central review of pathology, surgical reports, and imaging. Tumors were evaluated for LOH1p/16q by microsatellite testing. EFS and overall survival were compared using the log-rank test between NWTS-5 and current studies.ResultsLOH1p/16q was detected in 49 of 1,147 evaluable patients with stage I/II disease (4.27%) enrolled in AREN03B2; 32 enrolled in AREN0532. LOH1p/16q was detected in 82 of 1,364 evaluable patients with stage III/IV disease (6.01%) in AREN03B2; 51 enrolled in AREN0533. Median follow-up for 83 eligible patients enrolled in AREN0532/0533 was 5.73 years (range, 2.84 to 9.63 years). The 4-year EFS for patients with stage I/II and stage III/IV disease with LOH1p/16 was 87.3% (95% CI, 75.1% to 99.5%) and 90.2% (95% CI, 81.8% to 98.6%), respectively. These results are improved compared with the NWTS-5 updated 4-year EFS of 68.8% for patients with stage I/II disease (P = .042), and 61.3% for patients with stage III/IV disease (P = .001), with trends toward improved 4-year overall survival. The most common grade 3 or higher nonhematologic toxicities with regimen M were febrile neutropenia (39.2%) and infections (21.6%).ConclusionAugmentation of therapy improved EFS for patients with favorable histology Wilms tumor and LOH1p/16q compared with the historical NWTS-5 comparison group, with an expected toxicity profile.
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- 2019
7. Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children's Oncology Group AREN0533 Study.
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Dix, David B, Seibel, Nita L, Chi, Yueh-Yun, Khanna, Geetika, Gratias, Eric, Anderson, James R, Mullen, Elizabeth A, Geller, James I, Kalapurakal, John A, Paulino, Arnold C, Perlman, Elizabeth J, Ehrlich, Peter F, Malogolowkin, Marcio, Gastier-Foster, Julie M, Wagner, Elizabeth, Grundy, Paul E, Fernandez, Conrad V, and Dome, Jeffrey S
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Rare Diseases ,Cancer ,Lung ,Lung Cancer ,Clinical Research ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Antineoplastic Combined Chemotherapy Protocols ,Biomarkers ,Tumor ,Child ,Child ,Preschool ,Cyclophosphamide ,Dactinomycin ,Doxorubicin ,Etoposide ,Female ,Humans ,Lung Neoplasms ,Male ,Neoplasm Staging ,Risk Factors ,Survival Rate ,Treatment Outcome ,Vincristine ,Wilms Tumor ,Clinical Sciences ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Purpose The National Wilms Tumor Study (NWTS) treatment of favorable histology Wilms tumor with lung metastases was vincristine/dactinomycin/doxorubicin (DD4A) and lung radiation therapy (RT). The AREN0533 study applied a new risk stratification and treatment strategy to improve event-free survival (EFS) while reducing exposure to lung RT. Methods Patients with favorable histology Wilms tumor and isolated lung metastases showing complete lung nodule response (CR) after 6 weeks of DD4A continued receiving chemotherapy without lung RT. Patients with incomplete response (IR) or loss of heterozygosity at chromosomes 1p/16q received lung RT and four cycles of cyclophosphamide/etoposide in addition to DD4A drugs (Regimen M). AREN0533 was designed to preserve a 4-year EFS of 85% for lung nodule CR and improve 4-year EFS from 75% to 85% for lung nodule IR. Results Among 292 assessable patients, 133 had CR and 159 had IR. For patients with CR, 4-year EFS and overall survival (OS) estimates were 79.5% (95% CI, 71.2% to 87.8%) and 96.1% (95% CI, 92.1% to 100%), respectively. Expected versus observed event rates were 15% and 20.2% ( P = .052), respectively. For patients with IR, 4-year EFS and OS estimates were 88.5% (95% CI, 81.8% to 95.3%) and 95.4% (95% CI, 90.9% to 99.8%), respectively. Expected versus observed event rates were 25% and 12.2% ( P < .001), respectively. Overall, 4-year EFS and OS were 85.4% (95% CI, 80.5% to 90.2%) and 95.6% (95% CI, 92.8% to 98.4%) compared with 72.5% (95% CI, 66.9% to 78.1%; P < .001) and 84.0% (95% CI, 79.4% to 88.6%; P < .001), respectively, in the predecessor NWTS-5 study. Conclusion Excellent OS was achieved after omission of primary lung RT in patients with lung nodule CR, although there were more events than expected. EFS was significantly improved, with excellent OS, in patients with lung nodule IR using four cycles of cyclophosphamide/etoposide in addition to DD4A drugs. The overall AREN0533 treatment strategy yielded EFS and OS estimates that were superior to previous studies.
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- 2018
8. The frontline : a new focus for learning about leadership.
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CHERRY, Nita L
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- 2014
9. Sex Differences in Perceptions of Sleep Inertia Following Nighttime Awakenings
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Cassie J Hilditch, Sean Pradhan, Gregory Costedoat, Nicholas G Bathurst, Zachary Glaros, Kevin B Gregory, Nita L Shattuck, and Erin E Flynn-Evans
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Behavioral Sciences - Abstract
Study Objectives: The influence of biological sex on sleep inertia symptoms is currently unknown. We investigated the role of sex differences in the subjective experience and objective cognitive manifestation of sleep inertia following nighttime awakenings. Methods: Thirty-two healthy adults (16 female, 25.91 ± 5.63 years) completed a one-week at-home study with one experimental night during which sleep was measured by polysomnography and participants were awakened during their habitual sleep time. Participants completed a psychomotor vigilance task (PVT), Karolinska Sleepiness Scale (KSS), visual analog mood scales, and a descending subtraction task (DST) prior to sleep (baseline) and at 2, 12, 22, and 32 minutes after awakening. A series of mixed-effects models with Bonferroni-corrected post-hoc tests were used to examine the main effects of test bout and sex, and their interaction, with a random effect of participant, and order of wake-up and sleep history as covariates. Results: All outcomes except for percent correct on the DST showed a significant main effect of test bout, with worse performance after waking compared to baseline (all ps < .003). Significant effects of sex (p = .002) and sex × test bout (p = .01; R2M = .49, R2C = .69) were observed for KSS, with females reporting a greater increase in sleepiness from baseline to after waking compared to males. Conclusions: These results suggest that while females reported feeling sleepier than males following nighttime awakenings, their cognitive performance was comparable. Future research is needed to determine whether perceptions of sleepiness influence decision-making during the transition from sleep to wakefulness.
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- 2022
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10. Erratum: Reconfigurations in brain networks upon awakening from slow wave sleep: Interventions and implications in neural communication
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Hilditch, Cassie J., primary, Bansal, Kanika, additional, Chachad, Ravi, additional, Wong, Lily R., additional, Bathurst, Nicholas G., additional, Feick, Nathan H., additional, Santamaria, Amanda, additional, Shattuck, Nita L., additional, Garcia, Javier O., additional, and Flynn-Evans, Erin E., additional
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- 2024
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11. Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program.
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Roth, Michael E, O'Mara, Ann M, Seibel, Nita L, Dickens, David S, Langevin, Anne-Marie, Pollock, Brad H, and Freyer, David R
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Pediatric ,Pediatric Research Initiative ,Clinical Trials and Supportive Activities ,Clinical Research ,Prevention ,Pediatric Cancer ,Patient Safety ,Cancer ,Adolescent ,Adult ,Age Factors ,Child ,Child ,Preschool ,Clinical Trials as Topic ,Community Health Services ,Cross-Sectional Studies ,Databases ,Factual ,Female ,Humans ,Male ,Medical Oncology ,Patient Selection ,Retrospective Studies ,Young Adult ,Oncology & Carcinogenesis - Abstract
PurposeStagnant outcomes for adolescents and young adults (AYAs; 15 to 39 years old) with cancer are partly attributed to poor enrollment onto clinical trials. The National Cancer Institute (NCI) Community Clinical Oncology Program (CCOP) was developed to improve clinical trial participation in the community setting, where AYAs are most often treated. Further, many CCOP sites had pediatric and medical oncologists with collaborative potential for AYA recruitment and care. For these reasons, we hypothesized that CCOP sites enrolled proportionately more AYAs than non-CCOP sites onto Children's Oncology Group (COG) trials.MethodsFor the 10-year period 2004 through 2013, the NCI Division of Cancer Prevention database was queried to evaluate enrollments into relevant COG studies. The proportional enrollment of AYAs at CCOP and non-CCOP sites was compared and the change in AYA enrollment patterns assessed. All sites were COG member institutions.ResultsAlthough CCOP sites enrolled a higher proportion of patients in cancer control studies than non-CCOP sites (3.5% v 1.8%; P < .001), they enrolled a lower proportion of AYAs (24.1% v 28.2%, respectively; P < .001). Proportional AYA enrollment at CCOP sites decreased during the intervals 2004 through 2008 and 2009 through 2013 (26.7% v 21.7%; P < .001).ConclusionDespite oncology practice settings that might be expected to achieve otherwise, CCOP sites did not enroll a larger proportion of AYAs in clinical trials than traditional COG institutions. Our findings suggest that the CCOP (now the NCI Community Oncology Research Program) can be leveraged for developing targeted interventions for overcoming AYA enrollment barriers.
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- 2016
12. LBNO-DEMO: Large-scale neutrino detector demonstrators for phased performance assessment in view of a long-baseline oscillation experiment
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Agostino, L., Andrieu, B., Asfandiyarov, R., Autiero, D., Bésida, O., Bay, F., Bayes, R., Blebea-Apostu, A. M., Blondel, A., Bogomilov, M., Bolognesi, S., Bordoni, S., Bravar, A., Buizza-Avanzini, M., Cadoux, F., Caiulo, D., Calin, M., Campanelli, M., Cantini, C., Chaussard, L., Chesneanu, D., Colino, N., Crivelli, P., De Bonis, I., Déclais, Y., Dawson, J., De La Taille, C., Sanchez, P. Del Amo, Delbart, A., Di Luise, S., Duchesneau, D., Dulucq, F., Dumarchez, J., Efthymiopoulos, I., Emery, S., Enqvist, T., Epprecht, L., Esanu, T., Franco, D., Friend, M., Galymov, V., Gendotti, A., Giganti, C., Gil-Botella, I., Gomoiu, M. C, Gorodetzky, P., Haesler, A., Hasegawa, T., Horikawa, S., Ieva, M., Jipa, A., Karadzhov, Y., Karpikov, I., Khotjantsev, A., Korzenev, A., Kryn, D., Kudenko, Y., Kuusiniemi, P., Lazanu, I., Levy, J. -M., Loo, K., Lux, T., Maalampi, J., Margineanu, R. M., Marteau, J., Martin, C., Martin-Chassard, G., Mazzucato, E., Mefodiev, A., Mineev, O., Mitrica, B., Murphy, S., Nakadaira, T., Nessi, M., Nikolics, K., Nita, L., Noah, E., Novella, P., Nuijten, G. A., Ovsiannikova, T., Palomares, C., Patzak, T., Pennacchio, E., Periale, L., Pessard, H., Popov, B., Ravonel, M., Rayner, M., Regenfus, C., Ristea, C., Ristea, O., Robert, A., Rubbia, A., Sakashita, K., Sanchez, F., Santorelli, R., Scantamburlo, E., Sergiampietri, F., Sgalaberna, D., Slupecki, M., Soler, F. J. P., Stanca, D. L., Tonazzo, A., Trzaska, W. H., Tsenov, R., Vankova-Kirilova, G., Vannucci, F., Vasseur, G., Verdugo, A., Viant, T., Wu, S., Yershov, N., Zambelli, L., and Zito, M.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
In June 2012, an Expression of Interest for a long-baseline experiment (LBNO) has been submitted to the CERN SPSC. LBNO considers three types of neutrino detector technologies: a double-phase liquid argon (LAr) TPC and a magnetised iron detector as far detectors. For the near detector, a high-pressure gas TPC embedded in a calorimeter and a magnet is the baseline design. A mandatory milestone is a concrete prototyping effort towards the envisioned large-scale detectors, and an accompanying campaign of measurements aimed at assessing the detector associated systematic errors. The proposed $6\times 6\times 6$m$^3$ DLAr is an industrial prototype of the design discussed in the EoI and scalable to 20 kton or 50~kton. It is to be constructed and operated in a controlled laboratory and surface environment with test beam access, such as the CERN North Area (NA). Its successful operation and full characterisation will be a fundamental milestone, likely opening the path to an underground deployment of larger detectors. The response of the DLAr demonstrator will be measured and understood with an unprecedented precision in a charged particle test beam (0.5-20 GeV/c). The exposure will certify the assumptions and calibrate the response of the detector, and allow to develop and to benchmark sophisticated reconstruction algorithms, such as those of 3-dimensional tracking, particle ID and energy flow in liquid argon. All these steps are fundamental for validating the correctness of the physics performance described in the LBNO EoI., Comment: 217 pages, 164 figures, LBNO-DEMO (CERN WA105) Collaboration
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- 2014
13. Identifying and Addressing the Needs of Adolescents and Young Adults With Cancer: Summary of an Institute of Medicine Workshop
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Nass, Sharyl J, Beaupin, Lynda K, Demark‐Wahnefried, Wendy, Fasciano, Karen, Ganz, Patricia A, Hayes‐Lattin, Brandon, Hudson, Melissa M, Nevidjon, Brenda, Oeffinger, Kevin C, Rechis, Ruth, Richardson, Lisa C, Seibel, Nita L, and Smith, Ashley W
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Clinical Research ,Pediatric ,Cancer ,Rehabilitation ,7.1 Individual care needs ,7.3 Management and decision making ,Management of diseases and conditions ,Good Health and Well Being ,Adolescent ,Adult ,Humans ,National Academies of Science ,Engineering ,and Medicine ,U.S. ,Health and Medicine Division ,Neoplasms ,Survivors ,United States ,Young Adult ,Young adult ,Cancer survivorship ,Psychosocial aspects ,Fertility preservation ,Adverse effects ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Cancer is the leading disease-related cause of death in adolescents and young adults (AYAs). This population faces many short- and long-term health and psychosocial consequences of cancer diagnosis and treatment, but many programs for cancer treatment, survivorship care, and psychosocial support do not focus on the specific needs of AYA cancer patients. Recognizing this health care disparity, the National Cancer Policy Forum of the Institute of Medicine convened a public workshop to examine the needs of AYA patients with cancer. Workshop participants identified many gaps and challenges in the care of AYA cancer patients and discussed potential strategies to address these needs. Suggestions included ways to improve access to care for AYAs, to deliver cancer care that better meets the medical and psychosocial needs of AYAs, to develop educational programs for providers who care for AYA cancer survivors, and to enhance the evidence base for AYAs with cancer by facilitating participation in research.
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- 2015
14. Use of Appropriate Initial Treatment Among Adolescents and Young Adults With Cancer
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Potosky, Arnold L, Harlan, Linda C, Albritton, Karen, Cress, Rosemary D, Friedman, Debra L, Hamilton, Ann S, Kato, Ikuko, Keegan, Theresa HM, Keel, Gretchen, Schwartz, Stephen M, Seibel, Nita L, Shnorhavorian, Margarett, West, Michele M, and Wu, Xiao-Cheng
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Rare Diseases ,Cancer ,Pediatric Cancer ,Clinical Trials and Supportive Activities ,Lymphoma ,Hematology ,Clinical Research ,Pediatric ,7.3 Management and decision making ,Management of diseases and conditions ,Good Health and Well Being ,Adolescent ,Adult ,Female ,Germinoma ,Hodgkin Disease ,Humans ,Logistic Models ,Lymphoma ,Non-Hodgkin ,Male ,Neoplasms ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Quality of Health Care ,Registries ,Retrospective Studies ,SEER Program ,Sarcoma ,United States ,Young Adult ,AYA HOPE Study Collaborative Group ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
There has been little improvement in the survival of adolescent and young adult (AYA) cancer patients aged 15 to 39 years relative to other age groups, raising the question of whether such patients receive appropriate initial treatment. We examined receipt of initial cancer treatment for a population-based sample of 504 AYAs diagnosed in 2007-2008 with acute lymphoblastic leukemia (ALL), Hodgkin's or non-Hodgkin's lymphoma, germ cell cancer, or sarcoma. Registry data, patient surveys, and detailed medical record reviews were used to evaluate the association of patient demographic, socioeconomic, and health care setting characteristics with receipt of appropriate initial treatment, which was defined by clinical specialists in AYA oncology based on adult guidelines and published literature available before 2009 and analyzed with multivariable logistic regression. All statistical tests were two-sided. Approximately 75% of AYA cancer patients in our sample received appropriate treatment, 68% after excluding stage I male germ cell patients who all received appropriate treatment. After this exclusion, appropriate treatment ranged from 79% of sarcoma patients to 56% of ALL patients. Cancer type (P < .01) and clinical trial participation (P = .04) were statistically significantly associated with appropriate treatment in multivariable analyses. Patients enrolled in clinical trials were more likely to receive appropriate therapy relative to those not enrolled (78% vs 67%, adjusted odds ratio = 2.6, 95% confidence interval = 1.1 to 6.4). Except for those with early stage male germ cell tumors, approximately 30% (or 3 in 10) AYA cancer patients did not receive appropriate therapy. Further investigation is required to understand the reasons for this potential shortfall in care delivery.
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- 2014
15. Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma
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Khanna, Chand, Fan, Timothy M, Gorlick, Richard, Helman, Lee J, Kleinerman, Eugenie S, Adamson, Peter C, Houghton, Peter J, Tap, William D, Welch, Danny R, Steeg, Patricia S, Merlino, Glenn, Sorensen, Poul HB, Meltzer, Paul, Kirsch, David G, Janeway, Katherine A, Weigel, Brenda, Randall, Lor, Withrow, Stephen J, Paoloni, Melissa, Kaplan, Rosandra, Teicher, Beverly A, Seibel, Nita L, Smith, Malcolm, Üren, Aykut, Patel, Shreyaskumar R, Trent, Jeffrey, Savage, Sharon A, Mirabello, Lisa, Reinke, Denise, Barkaukas, Donald A, Krailo, Mark, and Bernstein, Mark
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Pediatric Cancer ,Pediatric Research Initiative ,Pediatric ,Orphan Drug ,Rare Diseases ,Cancer ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,Good Health and Well Being ,Animals ,Antineoplastic Agents ,Bone Neoplasms ,Disease Models ,Animal ,Disease Progression ,Dogs ,Drug Evaluation ,Preclinical ,Humans ,Osteosarcoma ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Despite successful primary tumor treatment, the development of pulmonary metastasis continues to be the most common cause of mortality in patients with osteosarcoma. A conventional drug development path requiring drugs to induce regression of established lesions has not led to improvements for patients with osteosarcoma in more than 30 years. On the basis of our growing understanding of metastasis biology, it is now reasonable and essential that we focus on developing therapeutics that target metastatic progression. To advance this agenda, a meeting of key opinion leaders and experts in the metastasis and osteosarcoma communities was convened in Bethesda, Maryland. The goal of this meeting was to provide a "Perspective" that would establish a preclinical translational path that could support the early evaluation of potential therapeutic agents that uniquely target the metastatic phenotype. Although focused on osteosarcoma, the need for this perspective is shared among many cancer types. The consensus achieved from the meeting included the following: the biology of metastatic progression is associated with metastasis-specific targets/processes that may not influence grossly detectable lesions; targeting of metastasis-specific processes is feasible; rigorous preclinical data are needed to support translation of metastasis-specific agents into human trials where regression of measurable disease is not an expected outcome; preclinical data should include an understanding of mechanism of action, validation of pharmacodynamic markers of effective exposure and response, the use of several murine models of effectiveness, and where feasible the inclusion of the dog with naturally occurring osteosarcoma to define the activity of new drugs in the micrometastatic disease setting.
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- 2014
16. Treatment of higher risk acute lymphoblastic leukemia in young people (CCG-1961), long-term follow-up: a report from the Children’s Oncology Group
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Steinherz, Peter G., Seibel, Nita L., Sather, Harland, Ji, Lingyun, Xu, Xinxin, Devidas, Meenakshi, and Gaynon, Paul S.
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- 2019
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17. Overcoming barriers to drug development and enrollment in clinical trials for adolescents and young adults with lymphoma
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Toner, Keri, primary, Allen, Carl E., additional, Jain, Shweta, additional, Kahl, Brad, additional, Leonard, John, additional, Wasserstrom, Heather, additional, Friedberg, Jonathan W., additional, Seibel, Nita L., additional, and Kelly, Kara, additional
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- 2023
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18. Enrollment of adolescent and young adult patients newly diagnosed with cancer in <scp>NCI CTEP</scp> ‐sponsored clinical trials before and after launch of the <scp>NCI</scp> National Clinical Trials Network
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Hari Sankaran, Shanda R. Finnigan, Lisa M. McShane, Ana F. Best, and Nita L. Seibel
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Young Adult ,Cancer Research ,Adolescent ,Oncology ,Data Collection ,Neoplasms ,Academies and Institutes ,Humans ,Medical Oncology ,National Cancer Institute (U.S.) ,United States - Abstract
Participation of adolescents and young adults (AYAs) in oncology clinical trials is important to ensure adequate opportunities for AYA patients to contribute to, and benefit from, advances in cancer treatment.Accrual data for National Cancer Institute (NCI) Cancer Therapy Evaluation Program (CTEP) cooperative group-led treatment trials were examined to assess enrollment of newly diagnosed AYA patients (15-39 years) during the period 2004-2019, with particular interest in comparing enrollment before launch of the NCI National Clinical Trials Network (NCTN) to after. All phase 2, 2/3, and 3 trials activated during the period between January 1, 2004, and December 31, 2019, were identified (n = 1568) and reduced to a set of 304 that met predetermined criteria to focus on cooperative group-led trials that involved therapy for newly diagnosed cancer and had age eligibility overlapping the AYA range. The proportion of AYA patients relative to total accrual, along with 95% bootstrapped CI was calculated for patients enrolled pre-NCTN and post-NCTN.AYA accrual comprised 9.5% (95% CI, 7.6-11.8) pre-NCTN compared with 14.0% (95% CI, 9.9-18.3) post-NCTN. The mean difference in proportions post-NCTN compared with pre-NCTN was 4.4% (0.7%-8.3%).These results indicate an increase in AYA participation in trials conducted within the NCTN relative to the pre-NCTN period. This suggests an awareness and utilization of NCTN trials for AYAs with cancer.
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- 2022
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19. Tazemetostat for Tumors Harboring SMARCB1/SMARCA4 or EZH2 Alterations: Results from NCI-COG Pediatric MATCH APEC1621C
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Chi, Susan N, primary, Yi, Joanna S, additional, Williams, P Mickey, additional, Roy-Chowdhuri, Sinchita, additional, Patton, David R, additional, Coffey, Brent D, additional, Reid, Joel M, additional, Piao, Jin, additional, Saguilig, Lauren, additional, Alonzo, Todd A, additional, Berg, Stacey L, additional, Ramirez, Nilsa C, additional, Jaju, Alok, additional, Mhlanga, Joyce C, additional, Fox, Elizabeth, additional, Hawkins, Douglas S, additional, Mooney, Margaret M, additional, Takebe, Naoko, additional, Tricoli, James V, additional, Janeway, Katherine A, additional, Seibel, Nita L, additional, and Parsons, D Williams, additional
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- 2023
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20. ALTERNATE STRESS MANAGEMENT BEHAVIORAL TECHNIQUES DURING SUSTAINED STRESSFUL PERIODS
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Shattuck, Nita L., Aten, Kathryn J., Tick, Simona L., Lester, Paul, Department of Defense Management (DDM), Gagnon, Stephen R., Shattuck, Nita L., Aten, Kathryn J., Tick, Simona L., Lester, Paul, Department of Defense Management (DDM), and Gagnon, Stephen R.
- Abstract
In this thesis, I use a meta narrative analysis approach to identity effective stress management techniques that fit the unique operational environment of the U.S. Navy from prior investigations. From the earlier literature, I identify effective behavioral techniques for stress management to include mindfulness, cognitive behavioral therapy, social resilience, physical activity, program interventions, meditation and mind-body medicine, emotion regulation, mental health awareness, self-care, and coping. I then map them to the domains of the Total Sailor Fitness used by the 21st Century Sailor initiative to provide stress management support to sailors. Furthermore, I analyze the responses to an exploratory questionnaire from two shore commands and find that sailors tend to use humor and engage in hobbies as social resilience techniques, although sailors perceive the most effective coping techniques to be video games and physical activity (aerobic exercise). These initial findings can inform a follow-on study that can augment the data collection within a pilot framework to support the assessment of the stress management programs currently offered by the Navy under the 21st Century Sailor initiative., NPS Naval Research Program, This project was funded in part by the NPS Naval Research Program., Lieutenant, United States Navy, Approved for public release. Distribution is unlimited.
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- 2023
21. SAFEGUARDING SLEEP: ASSESSING QUALITY OF LIFE FOR U.S. NAVY SENIOR LEADERS IN THE SURFACE FLEET
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Shattuck, Nita L., Cohick, David S., Operations Research (OR), Cornine, Crystal M., Shattuck, Nita L., Cohick, David S., Operations Research (OR), and Cornine, Crystal M.
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Senior leaders onboard U.S. Navy vessels afloat have constantly evolving schedules that are rarely consistent from day to day. Over the past two decades, studies of work and rest patterns have confirmed anecdotal reports of insufficient sleep of enlisted Sailors. The sleep of senior Officers has not been closely examined. Assessing sleep of surface fleet Officers as they perform their duties in the fleet may provide insight into the bigger picture of health and wellness in the U.S. Navy. As part of a multi-year project, sleep patterns of senior leaders were assessed while in training and in the fleet. An 18-month longitudinal data collection commenced when participants were attending Surface Warfare Schools Command (SWSC) in Newport, RI, and continued as participants assumed their operational positions in the fleet. This thesis takes an initial look into the sleep, mood, and other physiological patterns of senior leaders in these two settings over the first few months of the study. Participants completed validated questionnaires to assess their overall wellbeing and wore physiological monitors (ŌURA rings) to assess the duration and quality of their sleep. In this first opportunity to examine patterns in the data, we found statistically significant differences in sleep duration of senior leaders depending on where they were living and working; that is, when they were attending school, between school and operational command, and after they arrived at their operational command., Lieutenant, United States Navy, Approved for public release. Distribution is unlimited.
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- 2023
22. ASSESSING THE EFFECT OF A LIGHT INTERVENTION ON SLEEP QUALITY AND PERFORMANCE OF PENTAGON WATCHSTANDERS
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Shattuck, Nita L., Matsangas, Panagiotis, Operations Research (OR), Ramage, John L., Shattuck, Nita L., Matsangas, Panagiotis, Operations Research (OR), and Ramage, John L.
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Around the world, watchfloors provide information, intelligence, and technical support to operational commands 24 hours a day. Watchstanders often work long shifts surpassing full time 40-hour work weeks, which include night and weekend shifts. Shiftwork has been associated with a decreased amount of sleep in both quantity and quality, which leads to exhaustion and compromised cognitive function. Exposure to high energy visible (HEV) light at appropriate times has the potential to shift the body’s circadian rhythm to align faster to a new shift schedule. Adjusting to shifting work hours quicker could lead to less sleep loss, enhanced sleep quality, and less severe levels of fatigue. This study aims to assess the impact and potential benefits of intentionally introducing HEV light when watchstanders on a shore-based watchfloor are transitioning to a different work shift. The study will consider how the strategic application of HEV light affects circadian entrainment, thereby impacting sleep, performance, mood, and sleepiness. This work will inform recommendations to other shore-based watchfloors at the Pentagon that require non-traditional work schedules to support watchstanding operations., Naval Medical Research Center – Advanced Medical Development Program Silver Spring, MD 20910, Lieutenant Commander, United States Navy, Approved for public release. Distribution is unlimited.
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- 2023
23. Tazemetostat for Tumors Harboring SMARCB1/SMARCA4 or EZH2 Alterations: Results from NCI-COG Pediatric MATCH APEC1621C
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Susan N Chi, Joanna S Yi, P Mickey Williams, Sinchita Roy-Chowdhuri, David R Patton, Brent D Coffey, Joel M Reid, Jin Piao, Lauren Saguilig, Todd A Alonzo, Stacey L Berg, Nilsa C Ramirez, Alok Jaju, Joyce C Mhlanga, Elizabeth Fox, Douglas S Hawkins, Margaret M Mooney, Naoko Takebe, James V Tricoli, Katherine A Janeway, Nita L Seibel, and D Williams Parsons
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Cancer Research ,Oncology - Abstract
Background NCI-COG Pediatric MATCH assigns patients aged 1-21 years with refractory solid tumors, brain tumors, lymphomas, and histiocytic disorders to phase II trials of molecularly targeted therapies based on detection of pre-defined genetic alterations. Patients whose tumors harbored EZH2 mutations or loss of SMARCB1 or SMARCA4 by immunohistochemistry were treated with EZH2 inhibitor tazemetostat. Methods Patients received tazemetostat for 28-day cycles until disease progression or intolerable toxicity (max 26 cycles). The primary endpoint was objective response rate (ORR); secondary endpoints included progression-free survival (PFS) and tolerability of tazemetostat. Results Twenty patients (median age, 5 years) enrolled, all evaluable for response and toxicities. The most frequent diagnoses were atypical teratoid rhabdoid tumor (ATRT; n = 8) and malignant rhabdoid tumor (MRT; n = 4). Actionable alterations consisted of SMARCB1 loss (n = 16), EZH2 mutation (n = 3), and SMARCA4 loss (n = 1). One objective response was observed in a patient with non-Langerhans cell histiocytosis with SMARCA4 loss (26 cycles, 1200 mg/m2/dose twice daily). Four patients with SMARCB1 loss had a best response of stable disease: epithelioid sarcoma (n = 2), ATRT (n = 1), renal medullary carcinoma (n = 1). Six-month PFS was 35% (95% CI: 15.7%, 55.2%) and six-month OS, 45% (95% CI 23.1, 64.7%). Treatment-related adverse events were consistent with prior tazemetostat reports. Conclusion Although tazemetostat did not meet its primary efficacy endpoint in this population of refractory pediatric tumors (ORR: 5%, 90% CI 1%, 20%), 25% of patients with multiple histologic diagnoses experienced prolonged stable disease of > 6 months (range: 9-26 cycles), suggesting a potential effect of tazemetostat on disease stabilization.
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- 2023
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24. Reconfigurations in brain networks upon awakening from slow wave sleep: Interventions and implications in neural communication
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Hilditch, Cassie J., primary, Bansal, Kanika, additional, Chachad, Ravi, additional, Wong, Lily R., additional, Bathurst, Nicholas G., additional, Feick, Nathan H., additional, Santamaria, Amanda, additional, Shattuck, Nita L., additional, Garcia, Javier O., additional, and Flynn-Evans, Erin E., additional
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- 2023
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25. Table S1 from ARID5B Influences Antimetabolite Drug Sensitivity and Prognosis of Acute Lymphoblastic Leukemia
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Jun J. Yang, William E. Evans, William L. Carroll, Chunliang Li, Wentao Yang, Nita L. Seibel, Hui Zhang, Charnise Goodings, Shuyu E, Deepa Bhojwani, Xujie Zhao, and Heng Xu
- Abstract
Table S1 shows that downregulation of ARID5B led to more increases in LC50 of MTX and 6-MP than other antileukemic drugs
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- 2023
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26. Figure S1, S2, S3, S4, S5, S6, S7, S8, and S9 from ARID5B Influences Antimetabolite Drug Sensitivity and Prognosis of Acute Lymphoblastic Leukemia
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Jun J. Yang, William E. Evans, William L. Carroll, Chunliang Li, Wentao Yang, Nita L. Seibel, Hui Zhang, Charnise Goodings, Shuyu E, Deepa Bhojwani, Xujie Zhao, and Heng Xu
- Abstract
Figure S1 shows the knock-down effect of ARID5B with different shRNAs in Nalm6 cells; Figure S2 shows the correlation between MTX and 6-MP sensitivity with different levels of ARID5B knock-down in Nalm6 cells; Figure S3 shows that down-regulation of ARID5B mediated MTX and 6-MP drug resistance can be reversed by re-expression of ARID5B; Figure S4 shows that the levels of MTX and 6-MP active metabolites were reduced significantly after ARID5B knockdown; Figure S5 shows similar MTX and 6-MP drug resistance after CRISPR-mediated ARID5B downregulation; Figure S6 shows that decreased cell growth was detected by BrdU-uptake assay; Figure S7 shows treatment with increased concentrations of MTX and 6-MP led to gradually decreased p21 level; Figure S8 shows that a potential ARID5B binding site 25kb distal to CDKN1A locus was identified by ATAC-seq signal and Histone modification marks; Figure S9 shows an enrichment of components of the p53 signaling pathway was differentially expressed upon ARID5B knockdown.
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- 2023
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27. Data from ARID5B Influences Antimetabolite Drug Sensitivity and Prognosis of Acute Lymphoblastic Leukemia
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Jun J. Yang, William E. Evans, William L. Carroll, Chunliang Li, Wentao Yang, Nita L. Seibel, Hui Zhang, Charnise Goodings, Shuyu E, Deepa Bhojwani, Xujie Zhao, and Heng Xu
- Abstract
Purpose:Treatment outcomes for childhood acute lymphoblastic leukemia (ALL) have improved steadily, but a significant proportion of patients still experience relapse due to drug resistance, which is partly explained by inherited and/or somatic genetic alternations. Recently, we and others have identified genetic variants in the ARID5B gene associated with susceptibility to ALL and also with relapse. In this study, we sought to characterize the molecular pathway by which ARID5B affects antileukemic drug response in patients with ALL.Experimental Design:We analyzed association of ARID5B expression in primary human ALL blasts with molecular subtypes and treatment outcome. Subsequent mechanistic studies were performed in ALL cell lines by manipulating ARID5B expression isogenically, in which we evaluated drug sensitivity, metabolism, and molecular signaling events.Results:ARID5B expression varied substantially by ALL subtype, with the highest level being observed in hyperdiploid ALL. Lower ARID5B expression at diagnosis was associated with the risk of ALL relapse, and further reduction was noted at ALL relapse. In isogenic ALL cell models in vitro, ARID5B knockdown led to resistance specific to antimetabolite drugs (i.e., 6-mercaptopurine and methotrexate), without significantly affecting sensitivity to other antileukemic agents. ARID5B downregulation significantly inhibited ALL cell proliferation and caused partial cell-cycle arrest. At the molecular level, the cell-cycle checkpoint regulator p21 (encoded by CDKN1A) was most consistently modulated by ARID5B, plausibly as its direct transcription regulation target.Conclusions:Our data indicate that ARID5B is an important molecular determinant of antimetabolite drug sensitivity in ALL, in part, through p21-mediated effects on cell-cycle progression.
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- 2023
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28. Sex differences in perceptions of sleep inertia following nighttime awakenings
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Hilditch, Cassie J, primary, Pradhan, Sean, additional, Costedoat, Gregory, additional, Bathurst, Nicholas G, additional, Glaros, Zachary, additional, Gregory, Kevin B, additional, Shattuck, Nita L, additional, and Flynn-Evans, Erin E, additional
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- 2022
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29. Reconfigurations in brain networks upon awakening from slow wave sleep: Interventions and implications in neural communication
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Cassie J. Hilditch, Kanika Bansal, Ravi Chachad, Lily R. Wong, Nicholas G. Bathurst, Nathan H. Feick, Amanda Santamaria, Nita L. Shattuck, Javier O. Garcia, Erin E. Flynn-Evans, Hilditch, Cassie J, Bansal, Kanika, Chachad, Ravi, Wong, Lily R, Bathurst, Nicholas G, Feick, Nathan H, Santamaria, Amanda, Shattuck, Nita L, Garcia, Javier O, and Flynn-Evans, Erin E
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short-wavelength-enriched light ,Artificial Intelligence ,Applied Mathematics ,General Neuroscience ,graph theoretical framework ,sleep inertia ,network communication ,Computer Science Applications - Abstract
Sleep inertia is the brief period of impaired alertness and performance experienced immediately after waking. While the neurobehavioral symptoms of sleep inertia are well-described, less is known about the neural mechanisms underlying this phenomenon. A better understanding of the neural processes during sleep inertia may offer insight into the cognitive impairments observed and the awakening process generally. We observed brain activity following abrupt awakening from slow wave sleep during the biological night. Using electroencephalography (EEG) and a network science approach, we evaluated power, clustering coefficient, and path length across frequency bands under both a control condition and a blue-enriched light intervention condition in a within-subject design. We found that under control conditions, the awakening brain is typified by an immediate reduction in global theta, alpha, and beta power. Simultaneously, we observed a decrease in the clustering coefficient and an increase in path length within the delta band. Exposure to blue-enriched light immediately after awakening ameliorated these changes, but only for clustering. Our results suggest that long-range network communication within the brain is crucial to the waking process and that the brain may prioritize these long-range connections during this transitional state. Our study highlights a novel neurophysiological signature of the awakening brain and provides a potential mechanistic explanation for the effect of light in improving performance after waking.One sentence summaryBlue-enriched light partially accelerates the rapid prioritization of long-range communication within the human brain that characterizes sleep inertia
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- 2022
30. Rise and shine: The use of polychromatic short-wavelength-enriched light to mitigate sleep inertia at night following awakening from slow-wave sleep
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Cassie J. Hilditch, Lily R. Wong, Nicholas G. Bathurst, Nathan H. Feick, Sean Pradhan, Amanda Santamaria, Nita L. Shattuck, Erin E. Flynn‐Evans, Hilditch, Cassie J, Wong, Lily R, Bathurst, Nicholas G, Feick, Nathan H, Pradhan, Sean, Santamaria, Amanda, Shattuck, Nita L, and Flynn-Evans, Erin E
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Sleepiness ,Light ,Cognitive Neuroscience ,shiftwork ,General Medicine ,Sleep, Slow-Wave ,Circadian Rhythm ,Behavioral Neuroscience ,awakening ,on-call workers ,Humans ,Attention ,Female ,Wakefulness ,Sleep ,intervention ,reactive countermeasure ,Psychomotor Performance - Abstract
Sleep inertia is the brief period of performance impairment and reduced alertness experienced after waking, especially from slow-wave sleep. We assessed the efficacy of polychromatic short-wavelength-enriched light to improve vigilant attention, alertness and mood immediately after waking from slow-wave sleep at night. Twelve participants (six female, 23.3 ± 4.2 years) maintained an actigraphy-confirmed sleep schedule of 8.5 hr for 5 nights, and 5 hr for 1 night prior to an overnight laboratory visit. In the laboratory, participants were awakened from slow-wave sleep, and immediately exposed to either dim, red ambient light (control) or polychromatic short-wavelength-enriched light (light) for 1 hr in a randomized crossover design. They completed a 5-min Psychomotor Vigilance Task, the Karolinska Sleepiness Scale, and Visual Analogue Scales of mood at 2, 17, 32 and 47 min after waking. Following this testing period, lights were turned off and participants returned to sleep. They were awakened from their subsequent slow-wave sleep period and received the opposite condition. Compared with the control condition, participants exposed to light had fewer Psychomotor Vigilance Task lapses (χsup2/sup[1] = 5.285, p = 0.022), reported feeling more alert (Karolinska Sleepiness Scale: Fsub1,77/sub = 4.955, p = 0.029; Visual Analogue Scalesubalert/sub: Fsub1,77/sub = 8.226, p = 0.005), and reported improved mood (Visual Analogue Scalesubcheerful/sub: Fsub1,77/sub = 8.615, p = 0.004). There was no significant difference in sleep-onset latency between conditions following the testing period (tsub10/sub = 1.024, p = 0.330). Our results suggest that exposure to polychromatic short-wavelength-enriched light immediately after waking from slow-wave sleep at night may help improve vigilant attention, subjective alertness, and mood. Future studies should explore the potential mechanisms of this countermeasure and its efficacy in real-world environments.
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- 2021
31. Early-phase clinical trial eligibility and response evaluation criteria for refractory, relapsed, or progressive neuroblastoma: A consensus statement from the National Cancer Institute Clinical Trials Planning Meeting
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Julie R. Park, Judith G. Villablanca, Barbara Hero, Brian H. Kushner, Keith Wheatley, Klaus H. Beiske, Ruth L. Ladenstein, Sylvain Baruchel, Margaret E. Macy, Lucas Moreno, Nita L. Seibel, Andrew D. Pearson, Katherine K. Matthay, Dominique Valteau‐Couanet, Institut Català de la Salut, [Park JR] Seattle Children’s Hospital, Seattle, Washington, USA. Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA. [Villablanca JG] Children’s Hospital Los Angeles, Los Angeles, California, USA. Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [Hero B] Children’s Hospital, University of Cologne, Cologne, Germany. [Kushner BH] Memorial Sloan Kettering Cancer Center, New York, New York, USA. [Wheatley K] University of Birmingham, Birmingham, UK. [Beiske KH] Department of Pathology, Oslo University Hospital, Oslo, Norway. [Moreno L] Servei d'Hematologia i Oncologia Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
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Cancer Research ,Consensus ,Neuroblastoma - Tractament ,neoplasias::neoplasias por tipo histológico::neoplasias de células germinales y embrionarias::tumores neuroectodérmicos::neoplasias neuroepiteliales::tumores neuroectodérmicos primitivos::tumores neuroectodérmicos primitivos periféricos::neuroblastoma [ENFERMEDADES] ,Presa de decisions ,diagnóstico::pronóstico::resultado del tratamiento [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Other subheadings::/therapy [Other subheadings] ,Diagnosis::Prognosis::Treatment Outcome [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Psychological Phenomena::Mental Processes::Thinking::Decision Making::Consensus [PSYCHIATRY AND PSYCHOLOGY] ,National Cancer Institute (U.S.) ,United States ,Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neoplasms, Neuroepithelial::Neuroectodermal Tumors, Primitive::Neuroectodermal Tumors, Primitive, Peripheral::Neuroblastoma [DISEASES] ,3-Iodobenzylguanidine ,Neuroblastoma ,Treatment Outcome ,Oncology ,Avaluació de resultats (Assistència sanitària) ,Humans ,fenómenos psicológicos::procesos mentales::pensamiento::toma de decisión::consenso [PSIQUIATRÍA Y PSICOLOGÍA] ,Child ,Otros calificadores::/terapia [Otros calificadores] - Abstract
Consensus criteria; Early phase; Neuroblastoma Criteris de consens; Fase inicial; Neuroblastoma Criterios de consenso; Fase inicial; Neuroblastoma Background International standardized criteria for eligibility, evaluable disease sites, and disease response assessment in patients with refractory, progressive, or relapsed high-risk neuroblastoma enrolled in early-phase clinical trials are lacking. Methods A National Cancer Institute–sponsored Clinical Trials Planning Meeting was convened to develop an international consensus to refine the tumor site eligibility criteria and evaluation of disease response for early-phase clinical trials in children with high-risk neuroblastoma. Results Standardized data collection of patient and disease characteristics (including specified genomic data), eligibility criteria, a definition of evaluable disease, and response evaluations for primary and metastatic sites of disease were developed. Eligibility included two distinct patient groups: progressive disease and refractory disease. The refractory disease group was subdivided into responding persistent disease and stable persistent disease to better capture the clinical heterogeneity of refractory neuroblastoma. Requirements for defining disease evaluable for a response assessment were provided; they included requirements for biopsy to confirm viable neuroblastoma and/or ganglioneuroblastoma in those patients with soft tissue or bone disease not avid for iodine-123 meta-iodobenzylguanidine. Standardized evaluations for response components and time intervals for response evaluations were established. Conclusions The use of international consensus eligibility, evaluability, and response criteria for early-phase clinical studies will facilitate the collection of comparable data across international trials and promote more rapid identification of effective treatment regimens for high-risk neuroblastoma. National Cancer Institute Pediatric and Adolescent Solid Tumor Steering Committee; Alex's Lemonade Stand Foundation for Childhood Cancer; Ben Towne Foundation; EVAN Foundation; Cancer Research UK Institute of Cancer Research, Grant/Award Number C347/A15403; National Institute for Health Research Research Methods Programme/Institute of Cancer Research Biomedical Research Centre.
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- 2022
32. UNDERSTANDING MOTIVATIONAL FACTORS OF PROBLEMATIC VIDEO GAMING IN THE USMC AND USN
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Shattuck, Nita L., Matsangas, Panagiotis, Crew Endurance Team, Operations Research (OR), Xu, Jason M., Shattuck, Nita L., Matsangas, Panagiotis, Crew Endurance Team, Operations Research (OR), and Xu, Jason M.
- Abstract
Video games have become a staple in entertainment since the inception of digital gaming and can be used as a healthy way of escaping the stresses of modern society. With the increased usage of technology, military personnel have easier access to computer/internet gaming through various platforms. However, through excessive exposure, video games may become problematic and even addictive. With the potential issues that problematic video gaming may have on the Naval mission, this study assessed the prevalence, severity, and associated factors of video gaming on 87 Sailors from two U.S. Navy warships and compared these results with data from three U.S. Marine Corps commands from a similar study (954 Marines). Results showed that higher–severity gamers experienced statistically higher levels of depression, anxiety, loneliness, stress, and were 35% more likely to experience daytime sleepiness and 48% more likely to have an alcohol problem than lower–severity gamers. The strongest motivations to game for greater severity gamers were to escape from reality, cope with stress, and to compete with other gamers. We did not identify substantive differences between Sailors and Marines who played videogames. Further studies are needed to evaluate whether videogaming is the cause of a drop in the well-being of greater severity gamers and to reliability assess the criteria for both “problematic” and “disordered” video gaming that are more suited for an operational military environment.
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- 2022
33. CIRCADIAN ENTRAINMENT IN MILITARY PILOTS: TRANSITIONING FROM DAY TO NIGHT FLIGHTS
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Shattuck, Nita L., Matsangas, Panagiotis, Operations Research (OR), Reily, James S., Shattuck, Nita L., Matsangas, Panagiotis, Operations Research (OR), and Reily, James S.
- Abstract
This study assessed the effectiveness of light exposure in transitioning aviation schedules from days to nights. We hypothesized that a single night of light treatment will delay melatonin onset and improve performance in a simulated flight task. Study participants were military pilots who flew four simulated flights: one baseline daytime flight and three consecutive night flights. Pilots were exposed to four hours of high energy visible (HEV) light (1,000 lux) on the second night but remained in dim light on the first and third nights. Saliva samples for determining melatonin levels were collected every half hour during the three nighttime data collections. Participants also completed questionnaires to include the Bedford Workload Scale and the Karolinska Sleepiness Scale. We tracked each participant’s circadian rhythm using their melatonin onset profiles over the three nights of the study. Pilot performance in a flight simulator was assessed for each of the three data collection sessions using three flight profiles of progressing difficulty. Results showed an average delay in melatonin onset mean of 1.33 hr (SD = .36 hr). Flight performance over the testing period did not show any significant changes. This study showed that light can be used to effectively delay the onset of melatonin, potentially providing a substantive advantage to personnel who must rapidly transition to new work schedules. Further study is recommended before implementing in operational conditions.
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- 2022
34. OFRP Phase Variation in Signature and Destructive Behaviors
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Cyber Academic Group (CAG), Naval Postgraduate School (U.S.), Naval Research Program (NRP), Department of Defense Management (DDM), Operations Research (OR), Aten, Kathryn J., Shattuck, Nita L., Matsangas, Panagiotis, Salem, Anita M., Tick, Simona L., Cyber Academic Group (CAG), Naval Postgraduate School (U.S.), Naval Research Program (NRP), Department of Defense Management (DDM), Operations Research (OR), Aten, Kathryn J., Shattuck, Nita L., Matsangas, Panagiotis, Salem, Anita M., and Tick, Simona L.
- Abstract
This study will investigate the destructive behavior surge during the maintenance phase of the Optimized Fleet Response Plan (OFRP). The Culture of Excellence Campaign's Perform to Plan effort will empower warfighting capability by fostering psychological, physical and emotional toughness. To meet this goal, the Navy needs to understand what encourages signature behaviors and reduces destructive behaviors and how these behaviors impact readiness. This study will provide critical insight to encourage signature behaviors and counter destructive behaviors. Researchers will use a mixed-methods, explanatory sequential design to answer the questions: What are the rates of signature and destructive behaviors during phases of OFRP? Do rates differ by command type? How do signature and destructive behaviors impact readiness?
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- 2022
35. UNDERSTANDING MOTIVATIONAL FACTORS OF PROBLEMATIC VIDEO GAMING IN THE USMC
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Matsangas, Panagiotis, Shattuck, Nita L., Operations Research (OR), Orpilla, Edrie John C., Matsangas, Panagiotis, Shattuck, Nita L., Operations Research (OR), and Orpilla, Edrie John C.
- Abstract
The goals of this thesis were to assess the prevalence of problematic video gaming within the United States Marine Corps (USMC), identify the motivational factors that lead Marines to engage in video gaming, assess the effects of video gaming on Marines’ lives, and investigate whether Marines use video gaming as a maladaptive coping mechanism. Survey data (n = 1,098 Marines) were collected from three USMC commands. In total, 847 Marines (91%) reported playing video games. Recreation and coping with stress were the most frequently reported motivational factors for playing video games. Most gamers (91%) reported playing video games while at home/off duty. In contrast, 20% of gamers reported playing video games while on duty/in port and 36% reported playing video games while underway/deployed. In our sample, five Marines (2%) were classified as disordered gamers. Disordered gamers reported using dysfunctional coping styles more frequently than the rest of gamers. Disordered gamers reported more severe symptoms of depression and anxiety, higher levels of loneliness, elevated daytime sleepiness, and more symptoms suggestive of heavy drinking. These findings led to three recommendations: a) educate Marines on the risks of problematic video gaming and the factors associated with gaming addiction, b) educate Marines on sleep hygiene practices, and c) implement strategies to mitigate the effects of problematic video gaming., Naval Postgraduate School, Monterey, CA 93940, Lieutenant Junior Grade, United States Navy, Approved for public release. Distribution is unlimited.
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- 2022
36. Early-phase clinical trial eligibility and response evaluation criteria for refractory, relapsed, or progressive neuroblastoma: A consensus statement from the National Cancer Institute Clinical Trials Planning Meeting
- Author
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Park, Julie R., Villablanca, Judith G., Hero, Barbara, Kushner, Brian H., Wheatley, Keith, Beiske, Klaus H., Ladenstein, Ruth L., Baruchel, Sylvain, Macy, Margaret E., Moreno, Lucas, Seibel, Nita L., Pearson, Andrew D., Matthay, Katherine K., Valteau-Couanet, Dominique, Park, Julie R., Villablanca, Judith G., Hero, Barbara, Kushner, Brian H., Wheatley, Keith, Beiske, Klaus H., Ladenstein, Ruth L., Baruchel, Sylvain, Macy, Margaret E., Moreno, Lucas, Seibel, Nita L., Pearson, Andrew D., Matthay, Katherine K., and Valteau-Couanet, Dominique
- Abstract
Background International standardized criteria for eligibility, evaluable disease sites, and disease response assessment in patients with refractory, progressive, or relapsed high-risk neuroblastoma enrolled in early-phase clinical trials are lacking. Methods A National Cancer Institute-sponsored Clinical Trials Planning Meeting was convened to develop an international consensus to refine the tumor site eligibility criteria and evaluation of disease response for early-phase clinical trials in children with high-risk neuroblastoma. Results Standardized data collection of patient and disease characteristics (including specified genomic data), eligibility criteria, a definition of evaluable disease, and response evaluations for primary and metastatic sites of disease were developed. Eligibility included two distinct patient groups: progressive disease and refractory disease. The refractory disease group was subdivided into responding persistent disease and stable persistent disease to better capture the clinical heterogeneity of refractory neuroblastoma. Requirements for defining disease evaluable for a response assessment were provided; they included requirements for biopsy to confirm viable neuroblastoma and/or ganglioneuroblastoma in those patients with soft tissue or bone disease not avid for iodine-123 meta-iodobenzylguanidine. Standardized evaluations for response components and time intervals for response evaluations were established. Conclusions The use of international consensus eligibility, evaluability, and response criteria for early-phase clinical studies will facilitate the collection of comparable data across international trials and promote more rapid identification of effective treatment regimens for high-risk neuroblastoma.
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- 2022
37. ARID5B Influences Antimetabolite Drug Sensitivity and Prognosis of Acute Lymphoblastic Leukemia
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Shuyu E, William E. Evans, Xujie Zhao, Chunliang Li, Charnise Goodings, Deepa Bhojwani, Hui Zhang, William L. Carroll, Heng Xu, Nita L. Seibel, Wentao Yang, and Jun J. Yang
- Subjects
0301 basic medicine ,Cancer Research ,Gene knockdown ,Somatic cell ,business.industry ,medicine.drug_class ,Cell ,Drug resistance ,Antimetabolite ,Article ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Oncology ,Downregulation and upregulation ,030220 oncology & carcinogenesis ,Cancer research ,Medicine ,Methotrexate ,business ,Childhood Acute Lymphoblastic Leukemia ,medicine.drug - Abstract
Purpose: Treatment outcomes for childhood acute lymphoblastic leukemia (ALL) have improved steadily, but a significant proportion of patients still experience relapse due to drug resistance, which is partly explained by inherited and/or somatic genetic alternations. Recently, we and others have identified genetic variants in the ARID5B gene associated with susceptibility to ALL and also with relapse. In this study, we sought to characterize the molecular pathway by which ARID5B affects antileukemic drug response in patients with ALL. Experimental Design: We analyzed association of ARID5B expression in primary human ALL blasts with molecular subtypes and treatment outcome. Subsequent mechanistic studies were performed in ALL cell lines by manipulating ARID5B expression isogenically, in which we evaluated drug sensitivity, metabolism, and molecular signaling events. Results: ARID5B expression varied substantially by ALL subtype, with the highest level being observed in hyperdiploid ALL. Lower ARID5B expression at diagnosis was associated with the risk of ALL relapse, and further reduction was noted at ALL relapse. In isogenic ALL cell models in vitro, ARID5B knockdown led to resistance specific to antimetabolite drugs (i.e., 6-mercaptopurine and methotrexate), without significantly affecting sensitivity to other antileukemic agents. ARID5B downregulation significantly inhibited ALL cell proliferation and caused partial cell-cycle arrest. At the molecular level, the cell-cycle checkpoint regulator p21 (encoded by CDKN1A) was most consistently modulated by ARID5B, plausibly as its direct transcription regulation target. Conclusions: Our data indicate that ARID5B is an important molecular determinant of antimetabolite drug sensitivity in ALL, in part, through p21-mediated effects on cell-cycle progression.
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- 2020
- Full Text
- View/download PDF
38. OFRP Phase Variation in Signature and Destructive Behaviors
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Aten, Kathryn J., Shattuck, Nita L., Matsangas, Panagiotis, Salem, Anita M., Tick, Simona L., Cyber Academic Group (CAG), Naval Postgraduate School (U.S.), Naval Research Program (NRP), Department of Defense Management (DDM), and Operations Research (OR)
- Subjects
Maintenance ,OFRP ,Culture of Excellence ,Destructive Behaviors ,Signature Behavior - Abstract
NPS NRP Executive Summary This study will investigate the destructive behavior surge during the maintenance phase of the Optimized Fleet Response Plan (OFRP). The Culture of Excellence Campaign's Perform to Plan effort will empower warfighting capability by fostering psychological, physical and emotional toughness. To meet this goal, the Navy needs to understand what encourages signature behaviors and reduces destructive behaviors and how these behaviors impact readiness. This study will provide critical insight to encourage signature behaviors and counter destructive behaviors. Researchers will use a mixed-methods, explanatory sequential design to answer the questions: What are the rates of signature and destructive behaviors during phases of OFRP? Do rates differ by command type? How do signature and destructive behaviors impact readiness? N1 - Manpower, Personnel, Training & Education This research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrp Chief of Naval Operations (CNO) Approved for public release. Distribution is unlimited.
- Published
- 2022
39. The Challenge of Measuring Epistemic Beliefs: An Analysis of Three Self-Report Instruments
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DeBacker, Teresa K., Crowson, H. Michael, Beesley, Andrea D., Thoma, Stephen J., and Hestevold, Nita L.
- Published
- 2008
40. National Cancer Institute Basket/Umbrella Clinical Trials
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Mariam Eljanne, Alice P. Chen, Shakuntala Malik, Lyndsay Harris, and Nita L Seibel
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0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Engineering ,MEDLINE ,Medical Oncology ,Article ,Workflow ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Biomarkers, Tumor ,medicine ,Humans ,Medical physics ,Precision Medicine ,Child ,Genetic testing ,Clinical Trials as Topic ,medicine.diagnostic_test ,business.industry ,Age Factors ,Cancer ,Precision medicine ,medicine.disease ,National Cancer Institute (U.S.) ,United States ,Clinical trial ,030104 developmental biology ,Oncology ,Drug development ,Child, Preschool ,030220 oncology & carcinogenesis ,Precision Medicine Initiative ,Mutation ,Portfolio ,Transcriptome ,business - Abstract
With advances in genetic testing and its common usage, the field of precision medicine has exploded in the field of oncology. The National Cancer Institute is uniquely positioned to lead in this area of research through its wide network of investigators, partnerships with pharmaceutical companies in drug development, and laboratory capabilities. It has developed a portfolio of trials as part of a Precision Medicine Initiative, that uses various basket/umbrella designs to increase the understanding of treatment of cancer through genetic selection and targeted therapies. This article describes these trials, ALCHEMIST, LungMAP, NCI/NRG ALK Trial, MPACT, NCI-MATCH, and pediatric MATCH, and their contributions to the area of precision medicine.
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- 2019
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41. More Questions Than Answers for Adolescents and Young Adults With Cancer
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Nita L. Seibel and Denise Riedel Lewis
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Gerontology ,Cancer Research ,Adolescent ,business.industry ,Cancer ,medicine.disease ,humanities ,Article ,Young Adult ,Oncology ,Neoplasms ,medicine ,Humans ,Young adult ,AcademicSubjects/MED00010 ,business - Abstract
Background For adolescents and young adults (AYAs, aged 15-39 years) with cancer, metastatic disease at diagnosis is the strongest predictor of mortality, but its associations with age and sociodemographic factors are largely unexplored. Methods Using Surveillance, Epidemiology, and End Results Program data from 2000 to 2016, we collected incident cases of poor-prognosis metastatic cancer (5-year survival < 50%) and compared the proportion, incidence, time trends, and incidence rate ratios for race and ethnicity, sex, and socioeconomic status among AYAs, middle-aged adults (aged 40-64 years) and older adults (aged 65-79 years). Results From 2000 to 2016, a total of 17 210 incident cases of poor-prognosis metastatic cancer were diagnosed in AYAs, 121 274 in middle-aged adults, and 364 228 in older adults. Compared with older patients, the proportion of AYAs having metastatic disease was equivalent or substantially lower in nearly every site except stomach and breast cancers, which were statistically significantly higher for AYAs compared with middle-aged and older adults (stomach: 57.3% vs 46.4% and 39.5%; breast: 6.6% vs 4.4% and 5.6%, respectively; 2-sided P
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- 2021
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42. Leaning in to Address Sleep Disturbances and Sleep Disorders in Department of Defense and Defense Health Agency
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Vincent Mysliwiec, Matthew S Brock, Jennifer L Creamer, Emmanuel P Espejo, Rachel R Markwald, Gregory N Matwiyoff, John T Peachey, Brian M O’Reilly, Nita L Shattuck, Daniel J Taylor, Wendy M Troxel, Anne Germain, Human Systems Integration Program, Naval Postgraduate School (U.S.), and Operations Research (OR)
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Sleep Wake Disorders ,Military Personnel ,Public Health, Environmental and Occupational Health ,Humans ,General Medicine ,Sleep - Abstract
Letter to the Editor, Military Medicine, 187, 5/6:155, 2022 17 USC 105 interim-entered record; under review. The article of record as published may be found at http://dx.doi.org/10.1177/0018720820906050 In their article entitled, “Engaging Stakeholders to Optimize Sleep Disorders Management in the U.S. Military: A Qualitative Analysis,” Abdelwadoud and colleagues conducted focus groups of service members, primary care managers (PCMs), and administrative stakeholders about their perceptions, experiences, roles in sleep management, stated education needs, and management of sleep disorders.1 The qualitative methods are rigorous, and the findings reinforce and nuance prior results, especially regarding key requirements from PCMs. We feel compelled, however, to further nuance the authors’ conclusion that “current military sleep management practices are neither satisfactory nor maximally effective” and offer specific examples of actions taken by the Department of Defense (DoD) and Defense Health Agency (DHA) in recognition of the significance of optimal sleep in combat readiness and overall health of service members. We offer here a succinct list of concrete efforts to support and implement substantial clinical, operational, research, or educational efforts by the DoD or DHA to improve sleep in service members and associated clinical challenges in this unique population. Identified in text as U.S. Government work.
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- 2021
43. Retail credit usage and relationship marketing
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Paden, Nita L.
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- 1996
- Full Text
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44. Understanding Motivational Factors of Problematic Video Gaming in the USMC and the US Navy
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Matsangas, Panagiotis, Shattuck, Nita L., Shattuck, Lawrence G., Lawrence-Sidebottom, Darian, Naval Postgraduate School (U.S.), Naval Research Program (NRP), and Operations Research
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Video Game ,addictive behaviors ,Problematic video gaming ,psychological functioning - Abstract
NPS NRP Executive Summary A significant percentage of active duty service members (ADSMs) spends free time playing video games. This recreational activity is not unexpected given the relatively young age of many ADSMs and the prevalence of video gaming in the US population. The military operational environment, however, is characterized by high levels of occupational stress and poor sleep conditions which can result in increased risk of depression, anxiety, and sleep disorders. In such conditions, video games may be a strategy for coping with stress. In contrast, excessive video gaming can become problematic because it has the potential to affect well-being and behavior. For example, excessive video gaming is associated with high stress levels (Milani et al., 2018), lower psychosocial well-being and psychological functioning (von der Heiden et al., 2019), loneliness and depression (Lemmens et al., 2011), and delinquency and aggressive behavior (Milani et al., 2018; Engelhardt et al., 2011; Ewoldsen et al., 2012). Video gaming may also interfere with sleep when gamers stay up late playing video games instead of sleeping (Matsangas, Shattuck, & Saitzyk, 2020). In extreme cases, video gaming can become an addiction. In the scientific literature, Internet Gaming Disorder (IGD) is associated with poor emotion regulation, impaired prefrontal cortex functioning and cognitive control, poor working memory and decision-making capabilities, and a neuronal deficiency similar to substance-related addictions (Kuss et al., 2018). Given its potential negative impact on individual and team performance, we propose to assess problematic video gaming in two samples: US Marine Corps personnel and US Navy sailors. Based on surveys and focus groups, the research approach will be tailored for the needs of each service. Data will be collected from personnel in up to three USMC commands, whereas data from USN sailors will be collected on two ships, one in port and one underway. The study will focus on assessing the prevalence and extent of playing video games, identify factors associated with this activity, address whether Marines and Sailors are using gaming as a maladaptive coping mechanism, and provide appropriate recommendations. HQMC Manpower and Reserve Affairs (M&RA) This research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrp Chief of Naval Operations (CNO) Approved for public release. Distribution is unlimited.
- Published
- 2021
45. SUITABILITY OF ROYAL AUSTRALIAN NAVY STANDARD WORK WEEK IN RELATION TO FATIGUE LEVELS FOR OPERATIONAL TASKINGS
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Matsangas, Panagiotis, Shattuck, Nita L., Tick, Simona L., Graduate School of Defense Management (GSDM), Attwood, Adam, Matsangas, Panagiotis, Shattuck, Nita L., Tick, Simona L., Graduate School of Defense Management (GSDM), and Attwood, Adam
- Abstract
This thesis assessed the manning structure of HMAS Warramunga in at-sea conditions against Navy Standard Work Week (NSWW) criteria such that a Scheme of Complement (SoC) is “sufficient” to meet the workload and sustainment requirements. IMPRINT Pro Forces Module was used to model planned activities and unplanned events of sailors to include the Marine Engineering Department to assess workload, daily sleep duration (DSD), training, service diversion activities, and task completion rates. Results showed that the crew slept less and worked more than the NSWW criteria. Also, completion rates for all but the highest priority events were low. These findings indicate crew had little surge capacity available without sacrificing administrative and maintenance tasks. With clearer understanding of the limitations on the ship imposed by crew size, decision-makers will be able to assign operational tasking based on knowledge of expected endurance of a ship to maintain such an operational tempo. Findings indicate that the NSWW in its current state should not be used solely to define ships’ SoC. However, using modeling and simulation (M&S) combined with SMEs’ knowledge will provide insight on crew workload, lead to improved SoC, and fulfill the ship’s Statement of Operating Intent (SOI). Another potential application of IMPRINT could be to assess the ship’s pre-sailing risk state based off the ship’s current manning levels and maintenance requirements., Lieutenant Commander, Royal Australian Navy, Approved for public release. distribution is unlimited
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- 2021
46. ANALYSIS OF SHORE-BASED SHIFTWORK SCHEDULE ROTATIONS AND SLEEP
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Shattuck, Nita L., Matsangas, Panagiotis, Operations Research (OR), Sheehan, Sarah A., Shattuck, Nita L., Matsangas, Panagiotis, Operations Research (OR), and Sheehan, Sarah A.
- Abstract
Navy and Marine Corps personnel, engaged in support and training operations, face challenges to obtaining consistent sleep due to shiftwork and rotating schedules. Shiftwork has been shown to decrease sleep quality and quantity, which contributes to fatigue and degraded cognitive functions including decision making, alertness, reaction time, problem solving, and ability to learn. When shift changes are more recurrent, the human body must adapt to artificial time changes more often, thereby increasing the likelihood of circadian misalignment and desynchrony. Circadian desynchrony reduces quality and quantity of sleep, which has a cascading negative effect on personnel performance. To ameliorate the negative effects of shift work, rapidly rotating schedules, and associated sleep deprivation, the timing of external cues may be intentionally modified to support circadian alignment to the required wake/work hours. Aligning more quickly to shifting work hours could result in decreased sleep deprivation, improved sleep quality, decreased fatigue, and reductions in the negative impact on cognitive function. This work assessed the current state of sleep, fatigue, mood, and performance of a shore-based watchfloor, establishing a baseline for further study and comparative analysis when a schedule change or intervention is introduced. This study will inform recommendations to shore-based watchfloors that utilize non-traditional work schedules to cover 24-hour operations.
- Published
- 2021
47. MEASURING RESILIENCE
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Shattuck, Nita L., Strawser, Bradley J., Matsangas, Panagiotis, Defense Analysis (DA), Boyle, Joshua L., Shattuck, Nita L., Strawser, Bradley J., Matsangas, Panagiotis, Defense Analysis (DA), and Boyle, Joshua L.
- Abstract
After nearly two decades of war in the Middle East and centuries of conflict, today’s service member is more vulnerable than ever. Our nation’s warriors can deploy to and redeploy from combat in a matter of hours, not the days, weeks, or months of the past. The growing, enduring, and repeating stressors of military service have placed a premium on creating resilient Soldiers, Sailors, Airmen, and Marines. Yet, currently, there is still a void of knowledge surrounding how best to tangibly assess or train the resilience of service members and how to proactively identify those who are at risk or headed toward risk of compromising their resilience. The aim of the current study is to associate physiological metrics with self-reported assessments to enable such a proactive approach to occur. The study occurred outside the sterile confines of the laboratory, choosing instead to follow 44 service members in their normal patterns of life. In collaboration with the University of Arizona, participants in the present study were asked to wear a commercially available health tracker, an ŌURA ring, while self-administering proven subjective assessments and “awareness training,” on an online platform. The results found statistically relevant associations between heart rate variability metrics and the subjective assessments of anxiety, depression, and compassion fatigue. Further studies are needed to confirm and explore these associations, as well as further analysis of the plethora of data., http://archive.org/details/measuringresilie1094566593, Major, United States Army, Approved for public release. distribution is unlimited
- Published
- 2021
48. DETERMINING OPERATIONAL READINESS USING THE SCHEDULING MANAGEMENT AID FOR RISK TRACKING (SMART) TOOL
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Shattuck, Nita L., Matsangas, Panagiotis, Operations Research (OR), Cole Gerry, Christine D., Shattuck, Nita L., Matsangas, Panagiotis, Operations Research (OR), and Cole Gerry, Christine D.
- Abstract
In 2017, two Arleigh Burke–class destroyers, USS John S. McCain and USS Fitzgerald, were each involved in collisions in the Pacific resulting in the deaths of 17 Sailors and injuries to several others. During the Comprehensive Review (CR) of these incidents, it was determined that fatigue, poor watchstanding habits, and the lack of professional knowledge were contributing factors. Since the occurrence of these shattering events, the U.S. Navy has implemented policies which mandate the use of circadian-based watchbills and has equipped leaders with tools and best practices to effectively manage crew fatigue. Though these efforts are trending in the right direction, the Navy currently lacks the ability to determine the level of operational readiness of each Sailor onboard. This study aims to further develop the Scheduling Management Aid for Risk Tracking (SMART) tool by developing new heuristics to address the issues identified by the CR and exploring alternative methods of importing data into the tool. Following the redevelopment of the tool, the functionality of SMART will be evaluated. The overarching goal of this thesis is to provide Commanding Officers with a tool which allows them to visualize the readiness of their crew members to allow them to reduce unnecessary risk and exercise deliberate risk, particularly during special evolutions., Lieutenant, United States Navy, Approved for public release. Distribution is unlimited.
- Published
- 2021
49. ANALYSIS OF SLEEP, MOOD, AND WORKLOAD OF ENGINEERING SAILORS ONBOARD USS GONZALEZ
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Matsangas, Panagiotis, Shattuck, Nita L., Operations Research (OR), Veloria, Mariano Gabriel D., Matsangas, Panagiotis, Shattuck, Nita L., Operations Research (OR), and Veloria, Mariano Gabriel D.
- Abstract
U.S. Navy Sailors assigned to surface ship engineering departments operate, maintain, and repair many systems that provide critical services such as propulsion, damage control, air conditioning, potable water, electricity, and sewage. These engineering Sailors are expected to stand watch vigilantly and train constantly amid demanding work conditions and marginal manning levels. These issues potentially drive higher individual workload, restrict sleep opportunities, and erode crew morale. These challenges may be especially prevalent while ships are in the Basic Phase and may have been further exacerbated during the COVID-19 pandemic. Therefore, the objectives of this thesis are a) to assess the well-being, sleep attributes, and workload of engineering Sailors onboard USS Gonzalez (DDG 66), and b) to explore how the spread of COVID-19 affected the readiness of the department during the Basic Phase. Sailors were assessed using questionnaires, actigraphy, and self-report activity logs. Underway 1—dominated by 5/10 watch rotation and higher OPTEMPO—reflected worse mood compared to Underway 2, which was characterized by more 3/9 watch rotations and lower OPTEMPO (Underway 1 TMD: 68 ± 36.5; Underway 2 TMD: 53.1 ± 30.8; Wilcoxon signed rank test, n = 26, S = -103, p = 0.006). Mood, sleep quality, daytime sleepiness, insomnia symptoms, and proclivity to nap during Underway 1 and Underway 2 were worse compared to data collected from engineering departments across 14 other ships., Naval Medical Research Center - Adv Med Dept, Lieutenant, United States Navy, Approved for public release. Distribution is unlimited.
- Published
- 2021
50. Understanding Motivational Factors of Problematic Video Gaming in the USMC and the US Navy
- Author
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Naval Postgraduate School (U.S.), Naval Research Program (NRP), Operations Research, Matsangas, Panagiotis, Shattuck, Nita L., Shattuck, Lawrence G., Lawrence-Sidebottom, Darian, Naval Postgraduate School (U.S.), Naval Research Program (NRP), Operations Research, Matsangas, Panagiotis, Shattuck, Nita L., Shattuck, Lawrence G., and Lawrence-Sidebottom, Darian
- Abstract
A significant percentage of active duty service members (ADSMs) spends free time playing video games. This recreational activity is not unexpected given the relatively young age of many ADSMs and the prevalence of video gaming in the US population. The military operational environment, however, is characterized by high levels of occupational stress and poor sleep conditions which can result in increased risk of depression, anxiety, and sleep disorders. In such conditions, video games may be a strategy for coping with stress. In contrast, excessive video gaming can become problematic because it has the potential to affect well-being and behavior. For example, excessive video gaming is associated with high stress levels (Milani et al., 2018), lower psychosocial well-being and psychological functioning (von der Heiden et al., 2019), loneliness and depression (Lemmens et al., 2011), and delinquency and aggressive behavior (Milani et al., 2018; Engelhardt et al., 2011; Ewoldsen et al., 2012). Video gaming may also interfere with sleep when gamers stay up late playing video games instead of sleeping (Matsangas, Shattuck, & Saitzyk, 2020). In extreme cases, video gaming can become an addiction. In the scientific literature, Internet Gaming Disorder (IGD) is associated with poor emotion regulation, impaired prefrontal cortex functioning and cognitive control, poor working memory and decision-making capabilities, and a neuronal deficiency similar to substance-related addictions (Kuss et al., 2018). Given its potential negative impact on individual and team performance, we propose to assess problematic video gaming in two samples: US Marine Corps personnel and US Navy sailors. Based on surveys and focus groups, the research approach will be tailored for the needs of each service. Data will be collected from personnel in up to three USMC commands, whereas data from USN sailors will be collected on two ships, one in port and one underway. The study will focus on assessing the p
- Published
- 2021
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