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229 results on '"Nishiyama, Tsutomu"'

1. KL‐6 Mucin as Serum Tumor Marker of Metastatic Renal Cancer: A Case Report.

Author

Ishida, Kyohei, Hasegawa, Go, Takada, Toshinori, Ogose, Akira, Kawaguchi, Gen, Ikeda, Yohei, Nishiyama, Hiroki, Hara, Noboru, Nishiyama, Tsutomu, and Koga, Fumitaka

Subjects
RENAL cancer, TUMOR markers, BIOMARKERS, KIDNEY failure, METASTASIS
Abstract

We encountered a case of metastatic renal cell carcinoma in which the serum level of KL‐6, a therapeutic marker, was exceptionally high and fluctuated with the progression of treatment. A 74‐year‐old man was diagnosed with right renal cystic cancer and multiple metastases in October 2022. The KL‐6 level was 27490 U/mL. He started treatment with lenvatinib and pembrolizumab. KL‐6 decreased to 3885 U/mg in February 2023. The patient's proteinuria worsened, leading to the discontinuation of lenvatinib. KL‐6 increased to 25950 U/mL in April. He discontinued pembrolizumab and started taking cabozantinib. In September, drug‐induced bilateral inflammatory pneumonitis developed. He discontinued cabozantinb and began taking axitinib. KL‐6 decreased; however, he suffered from severe diarrhea and subsequent renal insufficiency. He discontinued axitinib in November. KL‐6 increased to 29640 U/mL in December. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Bladder Cancer Invading the Prostate and Penis and Multiple Bone Metastases Showing Significant Improvement after a Short‐Term Pembrolizumab Therapy following Radiation and Gemcitabine and Cisplatin Therapy Leading to a Pathologically Complete Remission

Author

Ishida, Kyohei, Ogose, Akira, Kawaguchi, Gen, Hasegawa, Go, Ikeda, Yohei, Hara, Noboru, Nishiyama, Tsutomu, and Sheikh, Mehraj

Subjects
FEMORAL neck fractures, PROSTATE cancer, BONE metastasis, SPONTANEOUS fractures, PELVIC bones, HIP fractures
Abstract

A 65‐year‐old man was diagnosed with bladder cancer invading the prostate and penis and multiple bone metastases. He underwent palliative radiation (30 Gy/10 fr) through vertebral bones (Th3 and Th12‐L5) and pelvic bones for pain control. The patient received pembrolizumab therapy after three courses of gemcitabine and cisplatin therapy. CT four weeks after starting pembrolizumab therapy showed that both the primary and metastatic lesions had notably reduced in size, and no new lesion was detected. He subsequently fell, resulting in a femoral neck pathological fracture, and underwent hemiarthroplasty. Pathological examination of the pathological fracture site revealed no residual tumor tissue. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Significance of PSA Screening in Niigata, Japan: Survey of Actual Status of New Cases of Prostate Cancer

Author

Saito, Toshihiro, primary, Komatsubara, Shuichi, additional, Hara, Noboru, additional, Nishiyama, Tsutomu, additional, Katagiri, Akiyoshi, additional, Ishizaki, Fumio, additional, Hatano, Akihiko, additional, Komeyama, Takeshi, additional, Hanyu, Shugo, additional, Terunuma, Masahiro, additional, Imai, Tomoyuki, additional, Go, Hideto, additional, Iida, Hiroaki, additional, Kurumada, Shigenori, additional, Yamaguchi, Shunsuke, additional, Takeda, Keisuke, additional, Ando, Takashi, additional, Hoshii, Tatsuhiko, additional, Kasahara, Takashi, additional, and Tomita, Yoshihiko, additional

Published
2021
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20. Clear Cell Adenocarcinoma of the Ureter Similar to Clear Cell Renal Cell Carcinoma Histology

Author

Watanabe, Kazuhiro, Hasegawa, Go, Ikeda, Yohei, Hara, Noboru, and Nishiyama, Tsutomu

Subjects
Article Subject
Abstract

A 70-year-old woman was referred to our hospital with gross hematuria and diagnosed with right invasive ureteral cancer and bladder urothelial carcinoma in situ. Intravesical BCG therapy and neoadjuvant chemotherapy with carboplatin and gemcitabine were performed at the same time. Subsequently, laparoscopic right nephroureterectomy was performed. Urothelial carcinoma in situ persisted; however, most of the tumor was clear cell carcinoma. The clear cell carcinoma lesion had clear cytoplasm with round nuclei and visible nucleoli in an insular arrangement as is the case with clear cell renal cell carcinoma. No transitional lesion between clear cell adenocarcinoma and urothelial carcinoma was presented. The clear cell carcinoma lesion was GATA3 negative and HNF4α positive; however, the urothelial cancer lesion was GATA3 positive and HNF4α negative. Clear cell carcinoma was diagnosed as clear cell adenocarcinoma similar to clear cell renal cell carcinoma histology.

Published
2021
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21. A comparative study of high-dose-rate brachytherapy boost combined with external beam radiation therapy versus external beam radiation therapy alone for high-risk prostate cancer

Author

Oshikane, Tomoya, primary, Kaidu, Motoki, additional, Abe, Eisuke, additional, Ohta, Atsushi, additional, Saito, Hirotake, additional, Nakano, Toshimichi, additional, Honda, Moe, additional, Tanabe, Satoshi, additional, Utsunomiya, Satoru, additional, Sasamoto, Ryuta, additional, Ishizaki, Fumio, additional, Kasahara, Takashi, additional, Nishiyama, Tsutomu, additional, Tomita, Yoshihiko, additional, Aoyama, Hidefumi, additional, and Ishikawa, Hiroyuki, additional

Published
2021
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28. Simultaneous Laparoscopic Surgery for Bladder Diverticulum and Urachal Remnant: A Case Report

Author

Murata, Masaki, Inui, Kohei, Hasegawa, Moto, Ikeda, Yohei, Nakagawa, Yuki, Hara, Noboru, and Nishiyama, Tsutomu

Subjects
surgical procedures, operative, Article Subject, urologic and male genital diseases
Abstract

A 44-year-old woman visited a hospital with microscopic hematuria in June 2009. Computed tomography showed a large bladder diverticulum at right lateral wall and urachal remnant. Cystoscopic examination showed a large diverticulum at the right lateral wall that closes to the dome. She was followed up closely without therapeutic intervention; however, the residual urine increased gradually and frequent bladder diverticulitis developed. She underwent laparoscopic bladder diverticulectomy and excision of the urachal remnant simultaneously without any complications in August 2017. Laparoscopic approach for a large bladder diverticulum and urachal remnant is useful with safe, effective, and minimally invasive.

Published
2019
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31. Prediction of pathological and oncological outcomes based on extended prostate biopsy results in patients with prostate cancer receiving radical prostatectomy: a single institution study

Author

Ishizaki Fumio, Hara Noboru, Koike Hiroshi, Kawaguchi Makoto, Tadokoro Akira, Takizawa Itsuhiro, Nishiyama Tsutomu, Takahashi Kota, and Hohenfellner Rudolf

Subjects
Extended prostate biopsy, Seminal vesicle involvement, Positive surgical margin, Perineural invasion, Pathology, RB1-214
Abstract

Abstract Background The prediction of pathological outcomes prior to surgery remains a challenging problem for the appropriate surgical indication of prostate cancer. This study was performed to identify preoperative values predictive of pathological and oncological outcomes based on standardized extended prostate biopsies with core histological results diagrammed/mapped in patients receiving radical prostatectomy for prostate cancer clinically diagnosed as localized or locally advanced disease. Methods In 124 patients with clinically localized or locally advanced prostate cancer (cT1c–cT3a) without prior treatment, pathological outcomes on the surgical specimen including seminal vesicle involvement (SVI), positive surgical margin (PSM), and perineural invasion (PNI) were studied in comparison with clinical parameters based on the results of 14-core prostate biopsies comprising sextant, laterally-directed sextant, and bilateral transition zone (TZ) sampling. Results Concerning the association of pathological outcomes with oncological outcomes, patients with PSM and PNI on surgical specimens had poorer biochemical-progression-free survival than those without PSM (logrank p = 0.002) and PNI (p = 0.003); it was also poorer concerning SVI, although the difference was not significant (p = 0.120). Concerning the impact of clinical parameters on these pathological outcomes, positive TZ and multiple positive biopsy cores in the prostatic middle were independent values predictive of SVI with multivariate analyses (p = 0.020 and p = 0.025, respectively); both positive TZ and multiple positive prostatic middle biopsies were associated with larger tumor volume (p Conclusions %positive cores and Gleason score in extended biopsies were independent values predictive of PSM and PNI in prostate cancer clinically diagnosed as localized or locally advanced disease, respectively, which were associated with poorer oncological outcomes. When diagramming biopsy-core results, extended biopsy may provide additional information for predicting oncological and pathological outcomes including SVI in patients clinically diagnosed as having localized or locally advanced disease. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8790262771042628

Published
2012
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41. Retroperitoneal fibrosis associated with IgG4-related disease diagnosed by prostate biopsy developed with acute post-renal renal failure: A case report

Author

Inui, Kohei, primary, Nakagawa, Yuki, additional, Watanabe, Hirofumi, additional, Hasegawa, Go, additional, Ikeda, Yohei, additional, Tsuchida, Masafumi, additional, Koda, Ryo, additional, Iino, Noriaki, additional, Hoshii, Tatsuhiko, additional, Nishiyama, Tsutomu, additional, and Tomita, Yoshihiko, additional

Published
2018
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43. 新潟大学医歯学総合病院におけるロボット支援前立腺全摘除術 : 初期87例の経験とラーニングカーブ短縮を目指した取り組み

Author

笠原, 隆, 丸山, 亮, 山名, 一寿, 瀧澤, 逸大, 西山, 勉, 冨田, 善彦, Kasahara, Takashi, Maruyama, Ryo, Yamana, Kazutoshi, Takizawa, Itsuhiro, Nishiyama, Tsutomu, Tomita, Yoshihiko, 笠原, 隆, 丸山, 亮, 山名, 一寿, 瀧澤, 逸大, 西山, 勉, 冨田, 善彦, Kasahara, Takashi, Maruyama, Ryo, Yamana, Kazutoshi, Takizawa, Itsuhiro, Nishiyama, Tsutomu, and Tomita, Yoshihiko

Abstract

【目的】ロボット支援前立腺全摘除術(RARP)の初期治療経験に関して検討を行った．【対象と方法】2014年2月より2016年5月までに，新潟大学医歯学総合病院にてRARPを行った87例を対象とした．第30例目以降の症例においては，手術ステップ別に目標時間を設定し，状況に応じてプロクターがデュアルコンソールを用いて技術指導を行った．手術成績に関しては，手術時期別に3群に分けて検討した．【結果】開腹手術や腹腔鏡手術への移行例は認めなかった．手術時期に比例して，全手術時間およびコンソール時間は有意に短縮し，術中出血量も有意に減少した．周術期合併症の発生率は，術中で0%，術後30日以内で11.5%であった．切除断端陽性率はpT2で16.8%，pT3で57.7％であった．術後の尿禁制率（尿パッド0-1枚／日）は術後1月，3月，6月，12月でそれぞれ43.7％，72.4％，87.3％，94.4％であった．【結論】「手術スキルの迅速な習得」を図るわれわれの試みは着実に成果を示しており，かつ安全性に関しても諸家の報告と比べ遜色なく実施できている．今後の課題は，特にpT2における断端陽性率を減少させるための工夫， および疾患コントロールに関する長期追跡による予後評価である．

Published
2017

44. 全身麻酔管理による日帰り前立腺生検の試み

Author

星井, 達彦, 紙谷, 義孝, 喜多, 学之, 山口, 征吾, 大橋, さとみ, 関口, 博史, 西山, 勉, Hoshii, Tatsuhiko, Kamiya, Yoshinori, Kita, Takayuki, Yamaguchi, Seigo, Ohhashi, Satomi, Sekiguchi, Hiroshi, Nishiyama, Tsutomu, 星井, 達彦, 紙谷, 義孝, 喜多, 学之, 山口, 征吾, 大橋, さとみ, 関口, 博史, 西山, 勉, Hoshii, Tatsuhiko, Kamiya, Yoshinori, Kita, Takayuki, Yamaguchi, Seigo, Ohhashi, Satomi, Sekiguchi, Hiroshi, and Nishiyama, Tsutomu

Abstract

前立腺癌疑い患者に対して前立腺生検が行われるが，全身麻酔または腰椎麻酔管理による前立腺生検では通常1～2泊の入院管理で行うことが多い．また日帰り前立腺生検では局所麻酔で行われることが多く，局所麻酔時や穿刺時に患者の苦痛が伴う．我々は2016年1月から全身麻酔管理による日帰り前立腺生検を行っている．全身麻酔管理による日帰り前立腺生検を行うにあたり「全身麻酔管理による日帰り前立腺生検クリニカルパス」を作成し行っている．前日夕食後は禁食とし，生検当日は水分を朝6時まで可とし，午前中に全身麻酔管理による日帰り前立腺生検を行う．前立腺生検はReal-time Virtual Sonography (RVS)を用いたMRI-経直腸的超音波検査同期狙撃生検3-6か所，系統生検左右各5か所の計13～16か所の経会陰的前立腺生検を行う．前立腺生検後3～4時間経過観察し，帰宅時チェックリストを用いてすべての項目で問題がないことを確認後帰宅する．2016年12月までの12ヶ月間に67例に全身麻酔管理による日帰り前立腺生検を施行した．1例で術後膀胱タンポナーデを，1例で術後尿閉を経験したが，再入院を必要とした症例はなく，そのほか周術期に問題となった症例はなかった．全身麻酔管理による日帰り前立腺生検は患者の苦痛が少なく，有用な方法と考えられる．

Published
2017

45. Additional file 2: Table S1. of Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen

Author

Takeda, Keisuke, Hara, Noboru, Nishiyama, Tsutomu, Tasaki, Masayuki, Ishizaki, Fumio, and Tomita, Yoshihiko

Abstract

Ct values of gene expression assessed by quantitative PCR in VCaP cells cultured with dihydrotestosterone-added media. Delta-delta Ct value was calculated from the following formula: delta(target gene Ct â internal control Ct) with specific cell culture media - delta(target gene Ct â internal control Ct) with standard cell culture media. (DOC 32 kb)

Published
2016
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48. Additional file 1: Figure S1. of Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen

Author

Takeda, Keisuke, Hara, Noboru, Nishiyama, Tsutomu, Tasaki, Masayuki, Ishizaki, Fumio, and Tomita, Yoshihiko

Abstract

Screening of the siRNA efficacy on target mRNA expression levels. Catalog numbers were s20580, s20581, and s20582 (Neon Transfection System; Life Technologies, Carlsbad, CA, USA) for siRNA NCOA2 #1 (siNCOA2 #1), #2 (siNCOA2 #2), and #3 (siNCOA2 #3), respectively. Based on this result, siRNA NCOA2 #2 was selected, and the relevant data were indicated in Fig. 5. (DOC 54 kb)

Published
2016
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49. Additional file 8: Figure S2. of Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen

Author

Takeda, Keisuke, Hara, Noboru, Nishiyama, Tsutomu, Tasaki, Masayuki, Ishizaki, Fumio, and Tomita, Yoshihiko

Abstract

Full membranes of Western blotting (corresponding to Fig. 7). The membrane in the left panel showed NCOA2 staining part, and the right showed actin beta staining part. Starting from the left lane, NCOA2 expressions in LNCaP with bicalutamide and without bicalutamide, and positive control were shown. Twenty-seven ug of Jurkat cell lysate (Catalog #611451, BD Biosciences, Franklin Lakes, NJ, USA) was used as positive control. Densitometry data of Western blotting were attached below them. (DOC 1266 kb)

Published
2016
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