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6. Corrigendum to: A comparative analysis of Pancoast tumour resection performed via video-assisted thoracic surgery versus standard open approaches (Interactive Cardiovascular and Thoracic Surgery (2014) 19:3 (426-435))

Author

Attilio Ignazio Lo Monte, Enrico Ruffini, Alfonso Fiorelli, Mario Santini, Francesco Paolo Caronia, Maurizio Nicolosi, Caronia, Francesco Paolo, Fiorelli, Alfonso, Ruffini, Enrico, Nicolosi, Maurizio, Santini, Mario, and Lo Monte, Attilio Ignazio

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Pancoast tumour, Settore MED/21 - Chirurgia Toracica, MEDLINE, 030204 cardiovascular system & hematology, Resection, Surgery, 03 medical and health sciences, Settore MED/18 - Chirurgia Generale, 0302 clinical medicine, Text mining, 030228 respiratory system, Video assisted thoracic surgery, Medicine, business, Cardiology and Cardiovascular Medicine
Published
2016

7. A comparative analysis of Pancoast tumour resection performed via video-assisted thoracic surgery versus standard open approaches

Author

Attilio Ignazio Lo Monte, Enrico Ruffini, Maurizio Nicolosi, Alfonso Fiorelli, Mario Santini, Francesco Paolo Caronia, Caronia, FP, Fiorelli, A, Ruffini, E, Nicolosi, M, Santini, M, Lo Monte, AI, Caronia Francesco, Paolo, Fiorelli, Alfonso, Ruffini, Enrico, Nicolosi, Maurizio, Santini, Mario, and Lo Monte Attilio, Ignazio

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Vital capacity, Time Factors, medicine.medical_treatment, Settore MED/21 - Chirurgia Toracica, Kaplan-Meier Estimate, Preoperative care, Pancoast tumour, Superior sulcus tumour, Video-assisted thoracoscopic resection, Surgery, Thoracotomy, Pancoast tumor, Risk Factors, medicine, Humans, Respiratory function, Neoplasm Invasiveness, Lung cancer, Pneumonectomy, Survival rate, Aged, Neoplasm Staging, Pain Measurement, Retrospective Studies, Analgesics, Pain, Postoperative, business.industry, Thoracic Surgery, Video-Assisted, Pancoast Syndrome, Recovery of Function, Pleural cavity, Middle Aged, medicine.disease, Settore MED/18 - Chirurgia Generale, medicine.anatomical_structure, Treatment Outcome, Italy, Anesthesia, Female, Cardiology and Cardiovascular Medicine, business
Abstract

OBJECTIVES: The aim of the present paper was to conduct a comparative analysis of outcomes after thoracoscopic resection versus standard thoracotomy approach in the treatment of Pancoast tumours. METHODS: All consecutive patients with Pancoast tumours undergoing surgical treatment from March 2000 to November 2012 were enrolled. Patients were divided into 2 groups according to whether a thoracoscopic or standard thoracotomy approach was adopted. In addition to morbidity and mortality, (i) intensity of pain; (ii) respiratory function focusing on the postoperative value and its variation with respect to the predicted value (Delta); (iii) analgesic consumption at different times during the postoperative course; and (iiii) survival rate were recorded in both groups and the inter-group differences were statistically compared. RESULTS: Of the 45 enrolled patients, 34 (75%) were included in the final analysis (18 in the thoracoscopic group and 16 in the standard group). Eleven (25%) patients were excluded because they (i) were unfit for surgery after induction therapy (n = 4); (ii) refused the operation (n = 1) or (iii) had unexpected pleural involvement (n = 6). Compared with the standard group, in the thoracoscopic group we observed less pain (P = 0.01), better recovery of forced vital capacity (P = 0.01) and forced expiratory value in 1 s (P < 0.001), and a reduction in opioid (P = 0.01) and analgesic consumption (P = 0.02). The median survival for all patients was 15 months. Patients with N0/N1 disease had better median survival than N2 patients (47 vs 9 months; P = 0.009). One local recurrence in the standard group was observed 1 year after operation, whereas 2 local recurrences, 1 in the thoracoscopic group and another in the standard group, were registered 2 years after the operation (P = 1.0). Finally, 4 (22%) extrathoracic metastases in the thoracoscopic group and 5 (31%) in the standard group (P = 0.8) were found over the 2 years following the procedure. CONCLUSIONS: In the management of Pancoast tumours, a thoracoscopic approach is safe and may be an effective adjunct to standard surgical resection in selected cases. Such an approach enabled surgeons to explore the pleural cavity and avoid exploratory thoracotomy in cases of unexpected pleural involvement. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Published
2014

8. Histology-based Combination Induction Chemotherapy for Elderly Patients with Clinical Stage III Non-small Cell Lung Cancer.

Author

Banna GL, Parra HJS, Castaing M, Dieci MV, Anile G, Nicolosi M, Strano S, Marletta F, Guarneri V, Conte P, and Lal R

Subjects
Aged, Aged, 80 and over, Carboplatin therapeutic use, Combined Modality Therapy, Deoxycytidine analogs & derivatives, Deoxycytidine therapeutic use, Female, Humans, Male, Neoplasm Staging, Pemetrexed therapeutic use, Treatment Outcome, Gemcitabine, Adenocarcinoma drug therapy, Adenocarcinoma pathology, Adenocarcinoma radiotherapy, Adenocarcinoma surgery, Antineoplastic Agents therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Non-Small-Cell Lung radiotherapy, Carcinoma, Non-Small-Cell Lung surgery, Carcinoma, Squamous Cell drug therapy, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell radiotherapy, Carcinoma, Squamous Cell surgery, Induction Chemotherapy, Lung Neoplasms drug therapy, Lung Neoplasms pathology, Lung Neoplasms radiotherapy, Lung Neoplasms surgery
Abstract

Aim: To explore the feasibility and activity of a histology-based induction combination chemotherapy for elderly patients with clinical stage III non-small cell lung cancer (NSCLC)., Patients and Methods: Patients aged ≥70 years with stage IIIA and IIIB lung squamous cell carcinoma (SCC) or adenocarcinoma were treated with three cycles of carboplatin and gemcitabine or pemetrexed, respectively, followed by definitive radiotherapy or surgery. The primary endpoint was the overall response rate (ORR) following induction., Results: Twenty-seven patients, with a median age of 74 years (range=70-80 years) were treated for adenocarcinoma in 14 (52%) and SCC in 13 (48%), clinical stage IIIA in eight (30%) and IIIB in 19 (70%). Grade 3 or 4 toxicity was reported for five patients (18.5%). The ORR was 46% in 12 (partial responses) out of 26 assessable patients., Conclusion: Histology-based induction combination chemotherapy is active and feasible in elderly patients with stage III NSCLC., (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2017
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