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The parametrically excited instability of the spatially periodic visco-elastomer sandwich plate with supported masses under quadrilateral longitudinal temporal harmonic excitations is studied. The improvability of the parametrically excited instability by periodic distribution parameters is explored. The direct eigenvalue analysis approach for solving the parametrically excited stability problem of the periodic sandwich plate system under longitudinal harmonic excitations is proposed. The spatial periodic distribution of facial layer thickness and core layer modulus of the sandwich plate is considered. The non-linear partial differential equations of longitudinal and transverse coupling motions of the periodic visco-elastomer sandwich plate with supported masses under biaxial longitudinal boundary excitations are derived. The longitudinal displacements of the sandwich plate are separated into two parts and the longitudinal boundary excitations relevant to symmetric part are incorporated into the sandwich plate system. Then the partial differential equations with boundary excitations are converted into parametrically excited system equations and further converted into ordinary differential equations with time-varying parameters, which describe the parametrically excited vibration with multi-mode coupling of the periodic sandwich plate system. The fundamental perturbation solution to the equations is expressed as the product of periodic and exponential parts based on the Floquet theorem. The ordinary differential equations with harmonic parameters are converted into a set of algebraic equations using the harmonic balance method. Then the parametrically excited instability of the periodic sandwich plate system is determined directly by matrix eigenvalues. The overall instability characteristics of parametrically excited vibration with multi-mode coupling of the system under longitudinal harmonic excitations are illustrated by numerical results on unstable regions. The parametrically excited instability can be improved by the spatially periodic distribution of geometrical and physical parameters. The proposed approach is applicable to general sandwich structures with spatial distribution parameters in multi-mode-coupling parametrically excited vibrations for overall instability analysis on continuous frequency band. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the effects and underlying mechanism of action of naloxone on lipopolysaccharide (LPS)-induced activation of retinal microglia in vitro., Methods: Rat retinal microglia primary cultures were divided into four treatment groups: untreated; 1 μg/ml LPS for 12 h; 0.5, 1.0 or 2.0 μM naloxone for 30 min before LPS; 2.5 or 5.0 μM SB203580 for 12 h before LPS and naloxone. Levels of tumour necrosis factor (TNF)-α and interleukin (IL)-1β were determined by enzyme-linked immuno sorbent assay. Western blot analysis and double immunofluorescence were used to examine activation of the mitogen activated protein kinase (MAPK) signalling pathway., Results: LPS induced an increase in TNF-α and IL-1β in culture supernatants, which was dose-dependently inhibited by naloxone. Naloxone also dose-dependently inhibited LPS-induced increases in phosphorylated p38 MAPK. Pretreatment of cells with SB203580 attenuated the inhibitory effect of naloxone on TNF-α and IL-1β production., Conclusions: Naloxone suppressed LPS-induced activation of cultured retinal microglia and this suppression appeared to occur partly through the p38 MAPK signalling pathway. Naloxone may have therapeutic potential in neuro degenerative diseases characterized by the activation of microglia.

This paper presents a nonlinear dynamic model for simulation and analysis of a kind of parametrically excited vibration of stay cable caused by support motion in cable-stayed bridges. The sag, inclination angle of the stay cable are considered in the model, based on which, the oscillation mechanism and dynamic response characteristics of this kind of vibration are analyzed through numerical calculation. It is noted that parametrically excited oscillation of a stay cable with certain sag, inclination angle and initial static tension force may occur in cable-stayed bridges due to deck vibration under the condition that the natural frequency of a cable approaches to about half of the first model frequency of the bridge deck system. A new vibration control system installed on the cable anchorage is proposed as a possible damping system to suppress the cable parametric oscillation. The numerical calculation results showed that with the use of this damping system, the cable oscillation due to the vibration of the deck and/or towers will be considerably reduced.