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Introdução: A lobomicose (também chamada de doença de Jorge Lobo) é uma doença granulomatosa crônica, causada pelo fungo Lacazia loboi, acomete principalmente trabalhadores rurais, geralmente após traumas locais em áreas cutâneas expostas. É mais comum em homens, de 20 a 40 anos, caracterizando-se por progressão lenta, no decorrer dos anos, de lesões cutâneas variadas, notadamente nódulos e placas coalescentes de aspecto queloideano. Sabe-se que lesões crônicas como essas podem malignizar, resultando principalmente no carcinoma espinocelular. Ao analisar os cânceres de pele, sugere-se que a lobomicose também tem correlação com a carcinogênese, embora seja pouco descrita na literatura e uma elucidação completa ainda não tenha sido traçada. Relato do caso: Homem, 63 anos, natural do Pará, trabalhador rural, portador de lobomicose e com história prévia de carcinoma basocelular com diferenciação escamosa em lóbulo da orelha e região pré-auricular direitos. Ele foi submetido à ressecção da lesão com margens em 2018, porém evoluiu após cerca de três anos com o surgimento, nas mesmas topografias, de nova lesão tumoral, desta vez com maior agressividade e com anatomopatológico compatível com carcinoma espinocelular. Conclusão: Tendo em vista a raridade da lobomicose em áreas não amazônicas, o caso em questão é fundamental para evidenciar que essa afecção pode associar-se com neoplasias de pele, contribuindo como fator de risco em razão da formação de cicatrizes e úlceras crônicas, além de alertar para a necessidade de diagnóstico e tratamento precoces, a fim de evitar a degeneração carcinomatosa.

Squamous cell carcinoma (SCC) is a malignant skin cancer that originates from spiny cells and can spread to other parts of the body. It is the second most common skin cancer, generally affecting people over 50, more often men with fair skin due to sun exposure and smoking. Risk factors include excessive sun exposure, immunosuppression, genetic predisposition, and chronic skin inflammation. In summary, SCC is a common skin cancer, with well-defined risk factors, varied clinical manifestations and diverse treatment, with early diagnosis being essential. for a better prognosis. Metastases are rare but can occur in high-risk cases. Early diagnosis and treatment are essential for a better response to established therapy as well as a better patient prognosis. We will explore an exemplary case of metastasis from cutaneous squamous cell carcinoma, emphasizing its clinical characteristics, diagnosis, prognostic factors and therapeutic approaches described in current literature. This will provide a comprehensive understanding to the clinical scenario. [ABSTRACT FROM AUTHOR]

Introducción: El cáncer de piel es una neoplasia frecuente a nivel mundial. El interferón es una sustancia natural que ayuda al sistema inmunitario a combatir enfermedades como esta, su uso terapéutico, ha sido evaluado en un gran número de investigaciones. Objetivo: Describir los resultados del tratamiento con interferón para el cáncer de piel. Método: realizó una búsqueda en Google académico, PubMed, MEDLINE y consultas de textos publicados en la Biblioteca Médica. Fueron evaluados artículos que se ajustaron al tema. Se estudiaron 50, de estos se referenciaron33. Desarrollo: El tratamiento del cáncer de piel no melanoma, con interferón muestra resultados favorables. Contribuye a la supervivencia con melanoma, es un procedimiento para la micosis fungoide y sarcoma de Kaposi. Conclusiones: Los interferones son un tratamiento con buenos resultados estéticos para el tratamiento del cáncer de piel y mejoran la calidad de vida de los pacientes.

Background: Facial nerve dysfunction is the principal postoperative complication related to parotidectomy.

This study aims to characterize the clinical, health assistance and demographic, of residents from midwest region of Brazil diagnosed with skin cancer. The goal is to understand the interstate trips made to receive the first treatment in the Unified Health System (SUS). An ecological analytical time-series study was conducted, analyzing population care characteristics from 2008 to 2018, using the Hospital Cancer Records and Mortality Information System database. Measures of association between variables were determined using Fisher and Chi-square tests. Of the registered cases, 42.2% were referred to another Federative Unit (UF) to undergo the first treatment. Specifically, 77.9% of cases registered in Goiás began treatment in another UF, while almost all cases in the DF underwent their first treatment in the same UF. Goiás (77.3%) and Mato Grosso (42.5%) were the states that sent the most users to another UF, with São Paulo receiving the highest number of users. Mortality from skin cancer increased by 44% during this period, particularly in Goiás and Mato Grosso do Sul. The results highlight variables associated with deficiencies in oncological care in the region, emphasizing the need for strategies to improve accessibility to treatments. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To describe the response to vismodegib in combination with cryotherapy as adjuvant in the treatment of locally advanced basal cell carcinoma. MATERIALS AND METHODS: A descriptive observational study was carried out, in which the clinical response of patients with locally advanced basal cell carcinoma treated with combination therapy (vismodegib with cryotherapy) was evaluated. Sex, age, time of evolution of the malignant lesion, histological subtype, lesion location and development of adverse events are described. RESULTS: Of 12 patients, 6 were women. Two of the 19 tumors presented a morpheaform pattern, the remaining presented a nodular and mixed pattern. Seven patients had complete clinical improvement and three had partial clinical improvement. The mean duration of treatment was 3.93 months and the mean number of cryotherapy sessions was 5.61. Four patients presented side effects. CONCLUSIONS: This is one of the first approaches showing favorable and safe results with the combined treatment of vismodegib and cryotherapy in a Latin American population. It is necessary to evaluate the probable response factors to small molecule therapy, the cost-effectiveness and the risk-benefit of this therapeutic option in a larger sample size. [ABSTRACT FROM AUTHOR]

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Background: Basal cell carcinoma (BCC) is the most prevalent cancer. A minority of BCCs have an aggressive behaviour (laBCC) and may require hedgehog pathway inhibitors such as sonidegib as its treatment. Objective: To describe the use of sonidegib in a large number of patients and provide more data on its real-life efficacy and safety profile. Methods: We conducted a retrospective and multicentric study that included patients treated with sonidegib. Epidemiological, effectiveness and safety data were collected. Results: A total of 82 patients with a mean age of 73.9 years were included. Ten patients had Gorlin syndrome. Median treatment duration was 6 months. Median follow-up duration was 34.2 months. Globally, 81.7% of the patients showed clinical improvement (52.4% partial response and 29.3% complete response), 12.2% clinical stability and 6.1% disease progression. There was no statistically significant difference in clinical improvement between the 24 h and 48 h sonidegib posology. After 6 months of treatment, 48.8% of the patients discontinued sonidegib. Prior vismodegib treatment and recurrent primary BCC were associated with a poorer response to sonidegib. At 6 months of treatment, 68.3% of the patients experienced at least one adverse effect. Conclusion: Sonidegib shows good effectiveness and acceptable safety profile in usual clinical practice. Resumen: Antecedentes: El carcinoma de células basales (CBC) es el cáncer más prevalente. Una minoría de CBC tiene un comportamiento agresivo (laBCC) y puede requerir inhibidores de la vía del erizo, como sonidegib como tratamiento. Objetivo: Describir el uso de sonidegib en un gran número de pacientes y aportar más datos sobre su perfil de eficacia y seguridad en la vida real. Métodos: Realizamos un estudio retrospectivo y multicéntrico que incluyó pacientes tratados con sonidegib. Se recogieron datos epidemiológicos, de eficacia y de seguridad. Resultados: Se incluyeron un total de 82 pacientes con una edad media de 73,9 años. Diez pacientes tenían síndrome de Gorlin. La mediana de duración del tratamiento fue de 6 meses. La mediana de duración del seguimiento fue de 34,2 meses. Globalmente, el 81,7% de los pacientes mostró mejoría clínica (52,4% respuesta parcial y 29,3% respuesta completa), el 12,2% estabilidad clínica y el 6,1% progresión de la enfermedad. No hubo diferencias estadísticamente significativas en la mejoría clínica entre la posología de sonidegib de 24 horas y de 48 horas. Después de 6 meses de tratamiento, el 48,8% de los pacientes suspendió sonidegib. El tratamiento previo con vismodegib y el CBC primario recurrente se asociaron con una peor respuesta a sonidegib. A los 6 meses de tratamiento el 68,3% de los pacientes experimentó al menos un efecto adverso. Conclusión: Sonidegib muestra un perfil de eficacia y seguridad mejor de lo esperado en la práctica clínica habitual.

The aim of this retrospective study was to evaluate the incidence of recurrence of non-melanoma skin cancer in Presidente Prudente; determine the epidemiological profile of these individuals and verify the agreement of the results with national data. The medical records of patients of any age, gender, or color, with a histopathological diagnosis of basal cell carcinoma or squamous cell carcinoma, treated surgically, with surgical margins free of neoplastic involvement, at the Hospital Regional de Presidente Prudente, from 2008 to 2018, were reviewed. looking for the number of recurrences in the first 5 years after surgical treatment. Of the total of 1,001 patients, 12.4% had recurrences, 55.7% were male and 92.9% were white. Chronic sun exposure was an important risk factor (97.2%), the face was the region with the greatest involvement in relation to primary lesions (87.2%) and the most common site of recurrence (56%). Recurrences were observed approximately 14 months after surgery in cases of basal cell carcinoma and 6.8 months in cases of squamous cell carcinoma. The recurrence incidence rate found (12.4%) is higher than the literature. The predominance of males, white color, sun exposure and the face as the main location of the crime agree with the literature. [ABSTRACT FROM AUTHOR]

Introducción: el conocimiento de las más avanzadas técnicas quirúrgicas que se emplean para el tratamiento del carcinoma epidermoide de labio es de gran importancia en la actualidad, donde el cáncer labial tiene alta incidencia. Objetivo: caracterizar las técnicas quirúrgicas empleadas en el tratamiento del carcinoma epidermoide de labio. Métodos: se realizó una revisión bibliográfica actualizada sobre el tema entre enero y febrero de 2023. Para ello se emplearon libros de texto y los recursos disponibles en la red Infomed, a través de las bases de datos Medline, Academic Search Premier, MedicLatina; además de Cudmed, Lilacs y Scopus. De un total de 156 artículos relacionados con la temática fueron seleccionados 25 de acuerdo a la fecha y relevancia. Desarrollo: las técnicas de reconstrucción labial dependen de la magnitud y localización del defecto. En lesiones queratósicas superficiales localizadas se utiliza la exéresis en losange y en las difusas la decorticación. Cuando toman menos de un tercio del labio se utiliza la técnica en V. Cuando centralmente toman más de un tercio y menos de dos tercios, se emplea generalmente la de Abbé-Estlander. En las laterales, la técnica de Estlander o Fan Flap de Gillies y en lesiones que toman más de dos tercios del labio se utiliza mayormente la de Karapandzic. Conclusiones: las técnicas quirúrgicas empleadas en el tratamiento del carcinoma epidermoide de labio tratan de adecuar a cada defecto una reconstrucción lo más estética y funcional posible.

Relatório apresentado às Jornadas Radiológicas de Rio Quarto, Argentina, em outubro de 1947. Antes de estudarmos, prática e objetivamente, a escolha da técnica ou do agente terapêutico a ser empregado em cada caso, faremos uma revisão sumária dos diferentes agentes e de alguns de seus princípios físicos com que temos de jogar para obtermos os resultados almejados.

As pesquisas médicas e cientificas sôbre o problema do câncer têm sido muito intensificadas nos úitimos dez anos. Êste terrivel mal mata mais de 200.000 norte-americanos anualmente; sua frequência continua aumentando e hoje é responsabilizado por 13,5 % de tôdas as mortes nos Estados Unidos. Ataca de modo igual os dois sexos em suas respectivas idades, mas é mais frequente nas 4ª 5ª e 6ª décadas da vida humana, órgão algum da economia escapa à sua devastação, si bem que tenha predileção característica pelo aparelho digestivo no homem e pelo genital na mulher. E’ mal traiçoeiro e inexorável que leva milhões de indivíduos à sepultura e deixa milhares outros mutilados e aterrorizados. O câncer da cabeça e do pescoço tem sido de particular importância para nós e cremos que seu estudo será muito oportuno e valioso. Pode ser responsabilizado por cerca de 6 de tôdas as mortes produzidas pelo câncer. Dividiremos nosso trabalho, do ponto de vista prático, nos seguintes itens: 1) Câncer cutâneo da região frontal, das pálpebras, do nariz, região geniana, lábio superior, lábio inferior, pavilhão auricular, conduto auditivo, crânio e pescoço; 2) Câncer dos seios da face; 3) Câncer da cavidade bucal, incluindo os localizados na região palatina, rebordo alveolar, mandibula, mucosa bucal, assoalho da bôca, lingua, amigdalas, lábios, naso-faringe, oro-faringe e hipo-faringe; 4) Câncer das glandulas salivares; 5) Câncer primitivo e metastático do pescoço; 6) Melanomas malignos da face e do pescoço e 7) Linfomas malignos da cabeça e do pescoço, incluindo a doença de Hodggkin e a leucemia. Até hoje se desconhece a verdadeira causa do câncer. Várias formas de irritação crônica e permanente têm sido estudadas como outros tantos fatores capazes de desencadear o câncer. Êstes fatores podem ser internos ou externos. Entre os primeiros citam-se algumas moléstias especificas, moléstias por carência e reações degenerativas. No segundo grupo estudam-se os traumatismos, os agentes químicos e as irradiações. As ulcerações crônicas, as leucoplasias e os papilomas que resultam de irritações crônicas, frequentemente precedem o processo canceroso ou fazem parte integrante do mesmo. Estas grandes forças de irritação e degenerativas existem na clínica diária e devem ser energicamente combatidas. A mortalidade pelo câncer pode ser reduzida de 50 % pelo tratamento sistemático das lesões pré-cancerosas e pela eliminação dos fatores irritativos crônicos. Contudo, nós com isto não atingimos ás forças básicas, intrínsecas, Intra-celulares e bio-químicas que, como resultado de certas alterações em sua estrutura química, produzem a transformação dos tecidos sãos, em tecidos neoplásicos.

Os progressos técnicos obtidos na primeira metade deste século, facilitando a indução química de tumores cutâneos em diversos animais experimentais, permitiram que se avançasse no estudo dos mecanismos biológicos envolvidos na carcinogênese. A pele de camundongo tem uma longa história como modelo vantajoso para esse tipo de pesquisa e as informações que se têm adquirido através do esclarecimento dos eventos que ocorrem durante a carcinogênese cutânea experimental indicam que o processo consiste de múltiplas etapas. As pesquisas mais recentes, que associam os modelos clássicos com fatores modificadores de processos químicos, têm elucidado alguns eventos essenciais para a carcinogênese.

Introdução: O retalho Keystone é um retalho em ilha, de vascularização confiável e dissecção simples, descrito pela primeira vez em 2003. Apesar de suas vantagens, é ainda pouco citado na literatura especializada e longe de se tornar opção de escolha na prática clínica da cirurgia reconstrutiva. O objetivo deste artigo é apresentar a experiência de um serviço oncológico de alta complexidade no uso de retalhos Keystone em reconstruções. Métodos: Um estudo retrospectivo foi desenvolvido por meio do levantamento de dados de prontuário de pacientes operados pela equipe de Cirurgia Plástica do Instituto do Câncer do Estado de São Paulo, além de análise de registros fotográficos pré, intra e pós-operatórios. Resultados: Nove pacientes foram identificados, todos portadores de comorbidades e média de idade de 52,7 anos. Os defeitos cutâneos se seguiram após ressecções oncológicas, sendo cinco em extremidades inferiores, três em tronco e um em face. A média da área ressecada foi de 52,6cm2. As reconstruções foram realizadas sob abreviado tempo cirúrgico. Não houve complicações pós- operatórias ou perdas do retalho e o tempo de hospitalização médio foi de 2,2 dias. Conclusão: O retalho Keystone é uma opção tecnicamente simples e reprodutível para a cobertura de ferimentos de tamanhos diversos e em localizações variadas. Devido à sua confiabilidade, dissecção simples e rápida, abreviado tempo de internação e baixa morbidade à área doadora, deve ser considerado na reconstrução de feridas oncológicas de diversas localizações, em pacientes de todas as idades.

Introdução: Os carcinomas de pele do tipo não melanoma são responsáveis por 30% dos tumores malignos no Brasil. O objetivo deste artigo foi avaliar o perfil epidemiológico e a conduta tomada a partir do diagnóstico histopatológico de margens comprometidas em pacientes com carcinomas de pele do tipo não melanoma tratados primariamente com cirurgia. Métodos: Estudo tipo coorte retrospectivo observacional. Os dados foram coletados de prontuário eletrônico de 1495 pacientes, apresentando 2457 carcinomas de pele do tipo não melanoma, operados entre janeiro de 2015 a dezembro de 2019. Resultados: Houve maior prevalência em homens (52,4%) e entre a sexta e a sétima décadas de vida (41,1%). O carcinoma basocelular foi o tipo histológico mais comum (75%). O risco de desenvolver carcinoma espinocelular foi 57,2% maior em pacientes com idade acima de 61 anos (risco relativo=1,572 (IC 95%: 1,316-1,878; p0,05). Conclusão: O estudo possibilitou melhor compreensão do perfil dos pacientes com carcinomas de pele do tipo não melanoma, bem como o percentual de margens comprometidas após excisão cirúrgica inicial e o tratamento realizado.

Skin cancer affects 30% of Brazilians and is the most prevalente cancer in the country. It can be melanoma or nonmelanoma. Melanoma accounts for only 3% of cases and the remainder corresponds to non-melanoma, which can manifest as basal cell carcinoma and squamous cell carcinoma. Despite the lower prevalence, melanomas have a high potential for metastasis and, as non-melanomas, have better prognosis with early diagnosis and, usually, the treatment is surgical. Thereby, this research is a survey of the prevalence of skin cancer confirmed by the histopathology of signs and tumors removed in outpatient surgery at a teaching servisse. That will be a source of information and knowledge for academics and the population in general, serving as a subsidy for research, scientific work and being a source of data in the elaboration of awareness policies, prevention, and fight against skin cancer by the Government and civilian organized society. [ABSTRACT FROM AUTHOR]

Immunotherapy is one of the most widely used treatments in recent years against basal cell carcinomas, melanomas, and other malignant skin conditions. This treatment has excellent benefits with a high degree of efficacy in these pathologies. However, various adverse effects have been reported that can complicate the treatment. This paper was developed to know the possible adverse effects that can arise when implementing immunotherapy. Secondary reactions in the hematological system are very frequent using immunotherapy; anemias and neutropenia are the most important in the hematological system, as well as alterations in the dermatological system, such as maculopapular rash. [ABSTRACT FROM AUTHOR]

Carta de Gulnar Azevedo e Silva Mendonça do Serviço de Epidemiologia/Pró-Onco, do Instituto Nacional de Câncer sobre o aumento do número de casos de melanoma e a preocupação crescente dos Dermatologistas e Oncologistas brasileiros sobre o fato.

Background: the purpose of photoprotection is the prophylaxis and repair of damage caused by solar radiation. Objective: to determine the level of knowledge about photoprotection from patients treated for skin cancer at the University Polyclinic "Aquiles Espinosa Salgado" from Las Tunas municipality, between October 2021 and October 2022. Methods: a prospective, descriptive study was carried out in 910 patients with manifestations of any form of photo damage, attended in the office and during the period of time defined above. The variables studied included knowledge about causes of skin cancer and other damages caused by the sun, nevi alarm elements, sun photoprotection measures, beneficial and harmful effects of the sun, reasons for not regularly using photoprotection and sources of information for such knowledge. Results: the total number of patients recognized what causes skin cancer and other sun damages, 94.2 % has knowledge about the warning elements of nevi and 90.7 % about sunburn. All patients knew about photoprotection measures. 88.1 % reported that products useful for protection are not available on the formal domestic market. 42.7 % recognize that the sun is involved in the synthesis of vitamin D as a beneficial effect and 94.1 % as a cause of premature aging. The main channels for obtaining information were the mass media (89.7 %) and health personnel (80.8 %). Conclusions: most patients have adequate knowledge about photoprotection.

Resumo A fístula arteriovenosa (FAV) é o principal acesso para hemodiálise devido à sua patência superior e menores índices de complicação quando comparada aos demais acessos para hemodiálise. Relatamos o caso de uma paciente do sexo feminino, de 69 anos, com doença renal crônica dialítica secundária a nefroesclerose hipertensiva com FAV radio-cefálica no membro superior esquerdo realizada há 9 anos. Há 2 anos, foi submetida a transplante renal e fazia uso de imunossupressores. Evoluiu com aparecimento de lesão crostosa em antebraço esquerdo há 3 meses, foi submetida a biópsia excisional, e foi evidenciado carcinoma espinocelular bem diferenciado e superficialmente invasivo, com margens cirúrgicas laterais e profundas livres de neoplasia. No seguimento de 1 ano, a paciente não apresentava sinais de recidiva neoplásica.

The main type of access used for hemodialysis is the arteriovenous fistula (AVF) because it offers superior patency and lower complication rates when compared to other hemodialysis accesses. We report the case of a 69-year-old female patient with chronic kidney disease on dialysis secondary to hypertensive nephrosclerosis with a radiocephalic AVF in the left upper limb created 9 years previously. Two years previously, she had undergone a kidney transplant and was taking immunosuppressants. A crusted lesion developed on her left forearm with onset 3 months before presentation and she underwent an excisional biopsy that revealed a well-differentiated and superficially invasive squamous cell carcinoma, with lateral and deep surgical margins free from neoplasia. At 1-year follow-up, the patient showed no signs of neoplastic recurrence. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to describe the disease and treatment and to alert health professionals for the identification of signs and symptoms and the need for an early diagnosis in patients with xeroderma pigmentosum (XP). Case description: An 8-year-old male patient was referred to the Joana de Gusmão Hospital (HIJG) in 2021 for evaluation and specialized care. Previously, the child was followed in his place of origin by oncologic and palliative care, where he was submitted to surgeries and chemotherapy. He was admitted to the HIJG using vismodegib, acitrein, tramadol, and solar protective measures. On physical examination, there were tumors and disseminated macular verrucous and ulcerated lesions. The imaging examination showed solid and expansive lesions on the face, and atelectasis and fibroscarring changes in the lung. The histopathological report proved the existence of melanocanthoma, carcinoma, and pyogenic granuloma. After the evaluation of the case, no surgery, chemotherapy, or radiotherapy was performed. It was decided to maintain the palliative treatment and to continue the use of tramadol for pain, and vismodegib and acitretin were used to control carcinomas and prophylactic measures. Comments: The XP is a rare disease of autosomal recessive inheritance whose mechanism comes from failure in the DNA repair by exposure to ultraviolet rays, resulting in lesions on the skin and mucous membranes. They start as sunburns and can progress to melanosis, areas with altered pigmentation, premature aging, poikiloderma, and areas of high risk for neoplasms. Keywords: Xeroderma pigmentosum; Ultraviolet rays; D [ABSTRACT FROM AUTHOR]

BACKGROUND: Bean syndrome is a rare congenital disorder associated with autosomal dominant inheritance, and mutation of chromosome 9p. It is characterized by multiple recurrent vascular malformations. CLINICAL CASE: A 14-year-old female patient who presented with intermittent headache, tachycardia and fatigue in daily activities. On physical examination, there were nodular violaceous raised lesions on the tongue, approximately 1 x 1 cm, non-bleeding. Additionally, disseminated red-violaceous nodular lesions were observed on the upper and lower limbs. In the endoscopic evaluation, there was evidence of multiple 2 to 8 mm red-violet elevated lesions from the esophago-gastric junction, stomach, to the second duodenal portion. The MRI showed solid tissue located to the left of the brain sickle at the level of the ipsilateral parietal lobe. The diagnosis was Bean syndrome associated with idiopathic thrombocytopenic purpura. Symptomatic treatment, blood transfusion and immunosuppressive management with sirolimus were provided. The evolution was favorable during admission and subsequent hospital admissions. CONCLUSIONS: The timely diagnosis of Bean syndrome is important for its adequate therapeutic management, due to its isolated presentation, considering a key factor the evaluation in young patients who present multiple skin lesions and gastrointestinal tract involvement that later leads to blood transfusions. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To describe the frequency of skin diseases in patients evaluated by the dermatology service of a second-level hospital in northeastern Mexico. MATERIALS AND METHODS: An observational, cross-sectional, and retrospective study was done from January 2020 to October 2021, including patients of all ages and both sexes. Age, sex and diagnosed dermatoses were analyzed. Diagnoses were coded according to the International Classification of Diseases 10th edition (ICD-10). RESULTS: Data from 1228 patients aged 0 to 94 years were extracted: 760 women and 468 men, with a median age of 49.0 years (IQR 42.7-45.2). The most frequent dermatoses were: papulosquamous disorders, eczema, skin appendage disorders, and malignant neoplasms. In terms of age, 15 to 20% of young people aged 0-18 years mainly presented skin appendage disorders and eczema; 25% of adults aged 19-65 years primarily presented papulosquamous disorders, and in older adults (older than 66 years) their primary condition was papulosquamous disorders and neoplastic lesions, present in > 20% of them. CONCLUSIONS: Eczema was the most frequent dermatosis in the young population, papulosquamous disorders in adults, while neoplastic lesions were the most common in eldery. [ABSTRACT FROM AUTHOR]

Introduction: basal cell carcinoma is the most common malignant tumor, which accounts for approximately 75 or 80 % of all non-melanoma skin cancer in whites. Studies concerning this issue at the northern care area of Ciego de Avila are lacked. Objective: to characterize clinically and epidemiologically all patients with basal cell carcinoma attended in the maxillofacial surgery service at the Hospital Provincial Docente “Roberto Rodríguez Fernández”, Morón, Ciego de Ávila, Cuba, from January 2019 to January 2020. Method: a cross-sectional descriptive observational study was conducted in 118 patients with this diagnosis, where the variables studied were as follow: age, sex, the anatomical location of tumor, predisposing factors, clinical forms of tumor and its clinical stage. Results: male sex (60.2%) and age group 60-74 years (51.7%) were predominant. Nodular clinical form was present in 44.1% of the total, with a higher incidence in the nasal region (39.8%). The predisposing factor in 97% of the cases was white or pink skin. The population studied was mostly in clinical stage II (43.2%). Conclusions: family pathological history, sun exposure and white or pink skin have a marked influence on the appearance of basal cell carcinoma, which allows an adequate diagnosis of the disease, as well as the development of health promotion and prevention activities for these predisposing factors.

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El carcinoma apocrino primario de glándula sudorípara es una neoplasia con una muy baja incidencia, que puede representar un reto diagnóstico, clínico e histológico, y un reto terapéutico local, adyuvante y de la enfermedad avanzada. La edad media de los pacientes es de alrededor de 67 años, y no se ha observado preferencia según el sexo. Se presenta con mayor frecuencia en las axilas y en el cuero cabelludo. Se caracteriza clínicamente por un lento crecimiento, aunque puede progresar agresivamente, con compromiso local, ganglionar y metastásico, principalmente, pulmonar, hepático y óseo. El tratamiento recomendado –una vez establecida la histología– consiste en una resección local amplia con un margen claro de 1 a 2 cm y linfadenectomía regional si se detectan ganglios clínicamente positivos. El tratamiento adyuvante (radioterapia o quimioterapia) y de la enfermedad avanzada no está claramente establecido. Se presentan dos pacientes de sexo femenino con sospecha inicial de cáncer de mama, en quienes se diagnosticó finalmente un carcinoma apocrino de glándula sudorípara.

Introdução: O sarcoma granulocítico (SG) é um tumor extramedular raro, composto por células mieloides imaturas. Ocorre em 2% a 14% dos pacientes com leucemia mieloide aguda (LMA). A associação com leucemia promielocítica (LPA) é ainda mais rara, especialmente como manifestação no momento do diagnóstico. O presente estudo expõe o caso de um paciente com SG cutâneo de apresentação concomitante ao diagnóstico de LPA. Relato do caso: Paciente do sexo masculino, 30 anos, encaminhado ao Departamento de Hematologia por febre, odinofagia, intensa adinamia, hiporexia, perda de 5 kg, sudorese noturna, além de dispneia progressiva ao longo de um mês. Realizou exames laboratoriais com evidência de anemia grave, prosseguindo investigação etiológica com mielograma, que evidenciou 84% de blastos, e imunofenotipagem compatível com LPA, PML-RARA positivo (90%). Apresentava ainda lesões ulceradas em região genital e coxa direita, cuja biópsia evidenciou proliferação de células redondas suspeita para infiltração por LMA/SG. A imuno-histoquímica confirmou SG. O paciente foi submetido à quimioterapia, com boa resposta ao tratamento e melhora das contagens sanguíneas. As lesões cutâneas evoluíram com cicatrização. Após terceira consolidação, o PML-RARA negativou. Conclusão: Este relato de caso descreve uma apresentação rara de uma doença hematológica maligna, o SG, também conhecido como cloroma, na pele. Uma estratégia de diagnóstico incluindo imagens, histopatologia, imuno-histoquímica e exames laboratoriais foi necessária para confirmá-lo. O diagnóstico oportuno é essencial para que o tratamento adequado seja instituído logo, beneficiando o paciente em sobrevida e qualidade de vida.

RESUMO Objetivo Analisar o perfil clínico de pacientes portadores de neoplasias escamosas da superfície ocular. Métodos Foram avaliados os principais fatores de risco envolvidos na gênese das neoplasias escamosas da superfície ocular, as características clínicas dos pacientes e os hábitos comportamentais associados. Foram incluídos neste trabalho de coorte histórica 80 pacientes com diagnóstico anatomopatológico de neoplasia escamosa da superfície ocular atendidos entre os anos de 2010 e 2020 em um hospital referência em oculoplástica e segmento anterior de Santa Catarina. Os dados clínicos e desfechos foram avaliados por meio da análise de prontuário e entrevista, sendo posteriormente tabulados no Excel e submetidos à analise estatística por meio do software Statistical Pakage for the Social Sciences, versão 16. Resultados Foi observado que 73,8% (n=59) eram do sexo masculino. A média de idade da amostra foi de 62 anos. Quanto ao fototipo de pele, de acordo com a escala de Fitzpatrick, constatou-se que a maioria apresentou os fototipos 1 e 2 (22; 27,5% e 44; 55%, respectivamente). Em relação à exposição ocupacional ao sol/radiação, 48% (n=60) apresentaram história de exposição ocupacional, sendo que, destes, 28 pacientes trabalhavam no setor de agricultura. Dos pacientes da amostra, 33 (41,2%) apresentavam histórico pessoal de neoplasias de pele, sendo que, destes, três apresentavam diagnóstico de xeroderma pigmentoso. Quanto ao hábito de uso de fatores de proteção solar, 61% (n=49) da amostra negou o hábito. Foi evidenciada associação estatisticamente significativa entre o hábito de usar fatores de proteção solar e histórico pessoal de neoplasias de pele. Em relação ao tipo de neoplasia escamosa, a maioria dos pacientes (72; 90%) apresentou diagnóstico anatomopatológico de carcinoma espinocelular ocular. Conclusão O perfil clínico epidemiológico dos pacientes portadores de neoplasias escamosas da superfície ocular neste estudo, predominantemente de carcinoma espinoceular ocular, foi de homens, idosos, de pele clara (fototipo 2) e com histórico importante de exposição aos raios solares ultravioleta A e B. Comorbidades imunodepressoras (HIV e transplante de órgão sólido) e doenças dermatológicas (albinismo e xeroderma pigmentoso) associaram-se ao aparecimento das neoplasias escamosas da superfície ocular em idade mais precoce. Em pacientes com histórico pessoal prévio de neoplasias de pele, foi evidenciado o hábito de uso de fatores de protetor solar mais presente em relação aos demais.

Introduction: Photodamage is the aggression caused by solar radiation in the skin. In turn, the ultraviolet radiation is one of the first agents considered as cancer generators. Objective: Characterize the patients with cutaneous neoplasms and other affections caused by photodamage, according to selected clinical variables. Methods: A cross-sectional, observational, clinical, descriptive and retrospective study of 64 patients diagnosed with some affection caused by photodamage was carried out, belonging to the health area of the doctor office No. 11 of Achiles Espinosa Salgado Polyclinic in Las Tunas, from January, 2020 to the same period in 2022. Some variables were analyzed, such as age, sex, color of the skin, skin photo type, occupation, regular use of solar protection means before the 18 years and now, as well as dermatologic disease caused by photodamage. Results: There was a prevalence of the 60 years and over age group (43.7 %), female sex (54.7 %), color of the skin white (98.5 %), skin photo type III (59.4 %) and the state workers (53.1 %). It was found that 90.6 % of the patients didn't have history of exhibition to non ultraviolet radiations; 25.0 % referred to use some means of protection regularly before the 18 years and 51.5 % use it at the moment. The dermatologic disease caused by photodamage that prevailed was the skin cancer (37.5 %). Conclusions: This study denoted the relevance and necessity to identify the clinical characteristics of the patients with affections caused by photodamage in the doctor office abovementioned. [ABSTRACT FROM AUTHOR]

Introduction and case presentation: We present a rare case of facial angiosarcoma that could be mistaken for cellulitis or lepromatous leprosy. Conclusion: The prognosis for the disease is still poor but there are good outcomes descripted with use of drugs such as Paclitaxel. [ABSTRACT FROM AUTHOR]

Introduction: Photodamage is the aggression caused by solar radiation in the skin. In turn, the ultraviolet radiation is one of the first agents considered as cancer generators. Objective: Characterize the patients with cutaneous neoplasms and other affections caused by photodamage, according to selected clinical variables. Methods: A cross-sectional, observational, clinical, descriptive and retrospective study of 64 patients diagnosed with some affection caused by photodamage was carried out, belonging to the health area of the doctor office No. 11 of Achiles Espinosa Salgado Polyclinic in Las Tunas, from January, 2020 to the same period in 2022. Some variables were analyzed, such as age, sex, color of the skin, skin photo type, occupation, regular use of solar protection means before the 18 years and now, as well as dermatologic disease caused by photodamage. Results: There was a prevalence of the 60 years and over age group (43.7 %), female sex (54.7 %), color of the skin white (98.5 %), skin photo type III (59.4 %) and the state workers (53.1 %). It was found that 90.6 % of the patients didn't have history of exhibition to non ultraviolet radiations; 25.0 % referred to use some means of protection regularly before the 18 years and 51.5 % use it at the moment. The dermatologic disease caused by photodamage that prevailed was the skin cancer (37.5 %). Conclusions: This study denoted the relevance and necessity to identify the clinical characteristics of the patients with affections caused by photodamage in the doctor office abovementioned.

O melanoma maligno cutâneo (MMC) é uma neoplasia da pele cuja incidência tem aumentado nas últimas décadas, e Santa Catarina é o estado com maior incidência em todo o país. Objetivo: Avaliar a localização, tamanho e profundidade das lesões por MMC em um laboratório de referência de patologia no sul de Santa Catarina no período entre 2007 e 2017. Metodologia: Foi realizado um estudo transversal documental retrospectivo, composto pelos laudos anatomopatológicos de pacientes cujas biópsias de pele foram encaminhadas ao laboratório estudado no período entre 2007 e 2017. Foram incluídos pacientes cujo laudo confirmou o diagnóstico de melanoma maligno cutâneo no período entre 2007 e 2017. Resultados: Foram analisados 232 casos de MMC. A maior prevalência ocorreu na faixa etária entre 50 e 69 anos. Foi constatado um aumento linear no número de ocorrências no período estudado. Foi encontrada associação estatisticamente significativa entre o índice de Breslow, a presença de ulceração e o número de mitoses tumorais (p

Background: the incidence of skin cancer has tripled, so knowledge about risk factors and prevention is necessary for the general practitioner in training.Objective: to diagnose the way in which the prevention of skin cancer is approached in the Dermatology subject.Methods: pedagogical research developed at the Cienfuegos University of Medical Sciences. The requirements for the treatment of the prevention of skin cancer in the Dermatology subject were analyzed. An interview was applied to an intentional sample of Dermatology professors and student surveys. The analysis of guiding documents, programs, etc. was carried out.Results: students receive the subject during their fifth year of the degree. All the professors agree that within the prevention topics taught in the career, the one related to skin cancer is not addressed; the 82.8% refer that the subject is addressed in a conference; basically the diagnosis of sick patients and the aspects of prevention are used with less relevance. All students agree that skin cancer is never mentioned as an important location that is susceptible to preventive measures; the 85.7% refer that it is a very long topic and more emphasis is placed on diagnosing injuries, classifying them, treating them and not on how to prevent them, in addition, many patients are not observed in practice in order to identify them.Conclusions: the way in which the topic of skin cancer prevention is approached in the Dermatology subject is not enough for what the general practitioner needs.

Background: cutaneous malignant melanoma is the most lethal skin tumor, so it is important to know the risk factors for mortality in patients who suffer from it. Objective: to determine the prognostic factors of mortality in patients with cutaneous malignant melanoma diagnosed and treated at the Celestino Hernández Robau Teaching University Hospital between January 2010 and December 2015. Method: a retrospective cohort analytical observational study was carried out. The population consisted of all patients with cutaneous malignant melanoma diagnosed and treated at the Hospital in the study period (N = 142), and the sample was 112 patients. The variables analyzed were: age, sex, skin color, histological subtype, Breslow index, Clark level, mitotic index, lymph node involvement, distant metastasis, ulceration, topographic location, clinical stage, type of treatment, and lactate dehydrogenase levels blood at diagnosis. The Odds Ratio (OR) and its confidence intervals (CI) were determined for the statistically significant factors. The area under the ROC curve was evaluated for the quantitative variables and a multivariate analysis was performed using Binary Logistic Regression. It was a reliability of 95 %. Results: the multivariate analysis identified as prognostic factors of mortality the Breslow index with a C statistic of 0.849 (CI: 0.770–0.923), the Clark V level (OR: 1.246; CI: 0.985-1.870), mitotic index ≥ 6mm2 (OR: 12.408; CI: 9.012-14.897), lymph node involvement ≥ 2 nodes (OR = 6.316; CI = 4.541-8.291), metastasis to lung or other viscera (OR: 6.206; CI: 4.342-8.001), tumor location on the head, neck or trunk (OR: 9.720; CI: 7.684-12.546), ulceration (OR: 0.528; CI: 0.120-0.856), non-surgical treatment (OR: 8.311; CI: 7.098-9.366) and the LDH value in blood ≥333 IU / l (OR: 18.905; CI: 14.750-21.053). Conclusions: the prognostic factors of mortality in patients with a diagnosis of cutaneous malignant melanoma were the Breslow index, the Clark level, the mitotic index, lymph node involvement, metastases to the lung or other viscera, the location of the tumor in the head, neck or trunk, the presence of ulceration, non-surgical treatment and the highest values of LDH in blood.

O carcinoma epidermoide (carcinoma escamocelular, carcinoma de células escamosas ou CEC) representa o segundo tipo de neoplasia cutânea mais comum. O CEC origina-se da proliferação atípica das células da camada espinhosa da epiderme e é mais frequente em indivíduos do sexo masculino, maiores de 50 anos, de fototipo baixo e com história de exposição solar. Descrevemos o caso de um homem de 61 anos, previamente hígido, apresentando lesão de crescimento rápido e exuberante na face, cujo anatomopatológico e imuno-histoquímica comprovaram tratar-se de CEC moderadamente diferenciado.

Introduction: Total rhinectomy is an uncommon procedure for the treatment of nasal malignancies, usually reserved for locally advanced tumors. There are few case series studying total rhinectomy in the literature, reporting conflicting results about recurrence and metastasis. Objective: Evaluate prognosis of total rhinectomy cases for malignant neoplasia in our institution. Methods: Retrospective review from January 2013 to September 2018, including all patients undergoing total rhinectomy in our Institution, under the care of the Head and Neck surgical team. Results: Ten patients were included, two men and eight women. The mean patient age was 71.6 years old. The majority had nasal skin (8 cases) carcinomas. Squamous cell carcinoma was present in seven cases. In total, six cases had regional metastasis, in a median period of 14.3 months. The overall mortality and disease specific mortality was 50% and 30%, respectively, in a median follow-up of 45.7 months. Conclusion: We observed high overall and disease-specific mortality among cases with advanced nasal malignancies undergoing total rhinectomy. Resumo: Introdução: A rinectomia total é um procedimento incomum para o tratamento de neoplasias nasais, geralmente reservado para tumores localmente avançados. Há poucas séries de casos que estudam a rinectomia total na literatura, as quais descrevem resultados conflitantes sobre recorrência e metástase. Objetivo: Avaliar o prognóstico de pacientes submetidos a rinectomia total por neoplasia maligna em nossa instituição. Método: Revisão retrospectiva de janeiro de 2013 a setembro de 2018, incluiu todos os pacientes submetidos a rinectomia total em nossa instituição, sob os cuidados da equipe de cirurgia de cabeça e pescoço. Resultados: Dez pacientes foram incluídos, dois homens e oito mulheres. A média de idade dos pacientes foi de 71,6 anos. A maioria apresentava carcinoma da pele nasal (oito casos). O carcinoma espinocelular estava presente em sete casos. Seis casos tiveram metástase regional em um período mediano de 14,3 meses. A mortalidade geral e a mortalidade específica da doença foram de 50% e 30%, respectivamente; o acompanhamento médio foi de 45,7 meses. Conclusão: Observamos alta mortalidade geral e específica da doença entre os casos com neoplasias nasais avançadas submetidas à rinectomia total.

Introduction: basal cell carcinoma is the most diagnosed skin cancer, which requires an adequate knowledge of its diagnosis, characteristics and treatment by the stomatologist given the incidence of patients with this pathology. Objective: to determine the level of knowledge of the Stomatology students of the Faculty of Medical Sciences of Manzanillo about basal cell carcinoma. Method: a descriptive, cross-sectional study was carried out in Stomatology students from the Faculty of Medical Sciences of Manzanillo, from April to May 2021. The universe consisted of 80 students belonging to the fourth and fifth year of Stomatology. A survey was made in Google Forms, where the variables referring to the level of knowledge of the students about basal cell carcinoma were studied. The level of knowledge was evaluated as good, regular and bad and for information processing a database was created in SPSS and Cronbach's alpha coefficient and Fisher's exact test were determined. Results: fifth-year Stomatology students predominated (82,5 %), a predominance of the level of regular knowledge in terms of epidemiology, anatomical location and treatment of basal cell carcinoma (48,75 %, 52,5 % and 56,25 % respectively) was observed and a good level of knowledge about the etiology of basal cell carcinoma (53,75 %) and 63,75 % of the students reported the need for a study on basal cell carcinoma. Conclusions: the level of knowledge it was Regular in most of the variables evaluated about the knowledge of basal cell carcinoma.

Cutaneous malignant melanoma (CMM) is a skin neoplasm with increasing incidence in the recent decades, and Santa Catarina is the state with the highest incidence in the entire country. Objective: To evaluate the location, size and depth of CMM lesions in a pathology reference laboratory in southern Santa Catarina between 2007 and 2017. Methodology: A retrospective cross-sectional documentary study was carried out, consisting of the anatomopathological reports of patients whose skin biopsies were sent to the laboratory studied in the period between 2007 and 2017. Patients whose report confirmed the diagnosis of cutaneous malignant melanoma in the period between 2007 and 2017 were included. Results: We analyzed 232 cases of CCM. The highest prevalence occurred in the 50 to 69 age group. There was a linear increase in the number of occurrences in the period studied. A statistically significant association was found between the Breslow index, the presence of ulceration and the number of tumor mitoses (p<0.001). Conclusion: The data found showed a significant association between the Breslow index, the presence of ulceration and the number of tumor mitoses. [ABSTRACT FROM AUTHOR]

Objective: To analyze the clinical profile of patients with ocular surface squamous neoplasms (OSSN). Methods: The main risk factors involved in the genesis of the ocular surface squamous neoplasms, the clinical features, and the behavioral habits associated were evaluated. This historical cohort study included 80 patients with anatomopathological diagnosis of OSSN who were treated between 2010-2020 at a reference hospital in oculoplastic and anterior segment in Santa Catarina. The clinical data and outcomes were evalated through the analysis of medical records and interviews, being later tabulated in Excel and analyzed using the SPSS 16 software. Results: Regarding the clinical profile of the patients in the sample, 73.8% (n = 59) were male. The mean age of the sample was 62 years old. As for the skin phototype, according to the Fitzpatrick scale, most of the sample presented the phototype 1 and 2 (27.5% n = 22; and 55% n = 44 respectively). Regarding occupational exposure to the sun / radiation, 48% (n = 60) had history of occupational exposure, and of these, 28 patients worked in the agricultural area. Of the patients of the sample, 33 (41.2%) had a personal history of skin neoplasms, and of these, 3 had diagnosis of xeroderma pigmentosum. As for the habit of using sun protection factors, 61% (n = 49) of the sample denied the habit. A statistically significant association was evidenced between the habit of using sun protection factors and people's history of skin cancer. Regarding the type of squamous neoplasia, most patients in the 90% sample (n = 72) had an anatomopathological diagnosis of ocular squamous cell carcinoma. Conclusion: The clinical epidemiological profile of patients with OSSN in this study, predominantly ocular squamous cell carcinoma, was men, elderly, fair-skinned (phototype 2) and with an important history of exposure to UVA and UVB rays. Immunosuppressive comorbidities (HIV, solid organ transplant) and dermatological diseases (albinism, xeroderma pigmentosum) are associated with the appearance of OSSN at an early age. In patients with a previous personal history of skin neoplasms, the habit of using sunscreen factors was more present than in the other patients. [ABSTRACT FROM AUTHOR]

El melanoma cutáneo es un tumor maligno que deriva de los melanocitos. Es el segundo cáncer en orden de frecuencia en mujeres de edad fértil, y por consiguiente, representa uno de los tipos de cáncer más frecuentes diagnosticados durante el embarazo. Se presentó una paciente embarazada de 32,5 semanas de edad gestacional, con cambios clínicos a nivel de un nevo preexistente. Se realizaron una dermatoscopia, la exéresis y la biopsia de la lesión, con diagnóstico histopatológico de melanoma maligno melanocítico nodular.

Introdução: a cirurgia micrográfica de Mohs (CMM) é capaz de alcançar altas taxas de cura no tratamento do câncer de pele e remover o mínimo possível de tecido saudável. Objetivos: caracterizar os pacientes submetidos à cirurgia micrográfica de Mohs e estudar fatores preditores de maior número de fases cirúrgicas. Métodos: estudo observacional, transversal, retrospectivo e descritivo realizado em serviço de referência para cirurgia micrográfica no período de 2013 a 2019. Foram revisados os prontuários de 230 pacientes (256 lesões). Resultados: lesões com recidiva tiveram significativamente mais número de fases que lesões sem recidiva (1,69 vs 1,31 fase). Tumores acima de 2cm tiveram maior número de fases que os de tamanho menor de 1cm e que aqueles entre 1,1 e 2,2cm (2,0 vs 1,08 e 1,22, respectivamente). Quando comparadas as localizações das lesões com o número de fases, não houve diferença significativa. Em relação aos subtipos histológicos pré-operatórios, houve diferença significativa: carcinomas basocelulares (CBC) agressivos precisaram de maior número de fases que os CBCs não agressivos. Conclusões: nosso estudo demonstra, corroborando dados da literatura, que os fatores de risco descritos estão diretamente relacionados a um maior número de estágios da cirurgia micrográfica de Mohs.

Complications are frequent in childhood segmental hemangiomas, so treatment of these lesions is necessary.Propranolol is currently the first line treatment in these cases. The case of a one-month-old infant with a segmental hemangioma of the face, diagnosed and treated at the Pediatric Hospital of Cienfuegos, is reported. He was given propranolol and showed almost complete lesion regression, maintaining the treatment for one year and any complication occurred.

Objetivo: Descrever a experiência de universitários no desenvolvimento de duas ações de conscientização sobre o câncer da pele. Síntese de dados: Os estudantes do curso de Medicina da Universidade Federal do Rio Grande do Norte, juntamente com médicos orientadores da Sociedade Brasileira de Dermatologia, elaboraram duas ações de conscientização para o combate ao câncer de pele associando medidas de educação em fotoproteção à aplicação de um questionário, visando ao planejamento futuro de ações mais direcionadas e eficazes. As ações ocorreram em duas praias durante o período de veraneio em 2020. Os banhistas, após responderem às perguntas, receberam orientações a respeito dos hábitos saudáveis de fotoproteção de acordo com o Consenso Brasileiro de Fotoproteção. Conclusão: Os voluntários consideraram êxito no planejamento e execução da ação, com boa aceitação por parte dos banhistas e das entidades contribuintes.

A orelha é uma das regiões com maior prevalência de tumores cutâneos, e a reconstrução dos defeitos auriculares resultantes de sua excisão, especialmente quando extensos e de espessura total, tende a ser complexa. São relatados dois casos de reconstruções de defeitos cirúrgicos auriculares, decorrentes da ressecção de carcinomas basocelulares por cirurgia micrográfica de Mohs, sendo um por meio de retalho em ilha interpolado mobilizado da região retroauricular através do próprio defeito primário, e outro por retalho de pele retroauricular com rotação anterior através do defeito primário - ambos com resultados estético e funcional satisfatórios.

Para a interpretação precisa dos achados intraoperatórios na cirurgia micrográfica de Mohs, é fundamental conhecer a histologia normal dos tecidos nas diferentes regiões anatômicas. Os cortes de congelamento avaliados pela técnica são obtidos na horizontal, diferentemente dos cortes verticais da análise anatomopatológica convencional. A partir do acervo de casos de um serviço de formação em Dermatologia, os cortes de congelamento de interesse em histologia topográfica foram digitalizados e detalhados, conforme revisão da literatura.

El cáncer de piel causa diferentes tipos de secuelas y su camuflaje estético es siempre un desafío. En la región facial, los defectos nasales son a menudo el resultado de la eliminación de lesiones cutáneas, como el carcinoma basocelular. El uso de colgajos locales es una de las opciones terapéuticas más utilizadas para la reconstrucción de estos defectos. Se describe la técnica del colgajo nasoglabelar, con una combinación de colgajos de rotación y frontal, empleada para la reconstrucción del defecto provocado por un carcinoma basal en región lateral de pirámide nasal, próximo al canto interno de ojo izquierdo, en un paciente masculino de 74 años, con antecedentes de lesiones basaloides, producto de exposición solar prolongada. Al examen físico se constató una lesión de bordes exofíticos, en forma de ulcus rodens, de un centímetro de diámetro, localizada en la pared lateral izquierda de la región nasal, cerca del canto medial del ojo izquierdo. Se realizó exéresis de la lesión, que resultó ser un carcinoma basocelular completamente resecado. Se realizó la reconstrucción del defecto mediante colgajo nasoglabelar de rotación semicircular. No hubo complicaciones postoperatorias y la evolución clínica del paciente fue satisfactoria.

Primary apocrine carcinoma of the sweat gland is a neoplasm with a very low incidence that may represent a clinical and histological diagnostic challenge, as well as for adequate local, adjuvant, and advanced disease management. The average age of patients is around 67 years with no gender preference. This cancer develops primarily at the axillary and scalp levels and is clinically characterized by slow growth, but can progress aggressively with local, nodal, and metastatic involvement (primarily lung, liver, and bone). The recommended management, once the histology is established, consists of a wide local resection with a clear margin of 1 to 2 cm and regional lymphadenectomy if clinically positive nodes are detected. The adjuvant treatment (radiotherapy or chemotherapy) and for the advanced disease is not established. We report here the cases of two female patients initially diagnosed with breast cancer who were finally diagnosed with apocrine carcinoma of the sweat gland. [ABSTRACT FROM AUTHOR]

Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista de Ciencias Médicas de Pinar del Río is the property of Editorial Ciencias Medicas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)