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1. Persisting Deficits in Health-Related Quality of Life of Colorectal Cancer Survivors 14–24 Years Post-Diagnosis: A Population-Based Study

Author

Melissa S. Y. Thong, Daniela Doege, Linda Weißer, Lena Koch-Gallenkamp, Lina Jansen, Heike Bertram, Andrea Eberle, Bernd Holleczek, Alice Nennecke, Annika Waldmann, Sylke Ruth Zeissig, Hermann Brenner, and Volker Arndt

Subjects
colorectal cancer, long-term survivors, health-related quality of life, population-based, non-cancer controls, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

(1) Background: The health-related quality of life (HRQOL) of colorectal cancer (CRC) survivors >10 years post-diagnosis is understudied. We aimed to compare the HRQOL of CRC survivors 14–24 years post-diagnosis to that of age- and sex-matched non-cancer controls, stratified by demographic and clinical factors. (2) Methods: We used data from 506 long-term CRC survivors and 1489 controls recruited from German population-based multi-regional studies. HRQOL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Core-30 (EORTC QLQ-C30) questionnaire. We estimated differences in the HRQOL of CRC survivors and controls with multiple regression, adjusted for age at survey, sex, and education, where appropriate. (3) Results: CRC survivors reported poorer social functioning but better health status/QOL than controls. CRC survivors, in general, had higher levels of symptom burden, and in particular diarrhea and constipation, regardless of demographic or clinical factors. In stratified analyses, HRQOL differed by age, sex, cancer type, and having a permanent stoma. (4) Conclusions: Although CRC survivors may have a comparable health status/QOL to controls 14–24 years after diagnosis, they still live with persistent bowel dysfunction that can negatively impact aspects of functioning. Healthcare providers should provide timely and adapted follow-up care to ameliorate potential long-term suffering.

Published
2023
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2. Estimating complete cancer prevalence in Europe: validity of alternative vs standard completeness indexes

Author

Elena Demuru, Silvia Rossi, Leonardo Ventura, Luigino Dal Maso, Stefano Guzzinati, Alexander Katalinic, Sebastien Lamy, Valerie Jooste, Corrado Di Benedetto, Roberta De Angelis, the EUROCARE-6 Working Group, M. Hackl, E. Van Eycken, N. Van Damme, Z. Valerianova, M. Sekerija, V. Scoutellas, A. Demetriou, L. Dušek, D. Krejici, H. Storm, M. Mägi, K. Innos, N. Malila, J. Pitkäniemi, M. Velten, X. Troussard, A.M. Bouvier, V. Jooste, A.V. Guizard, S. Dabakuyo Yonli, M. Maynadié, J.B. Nousbaum, G. Coureau, A. Monnereau, I. Baldi, K. Hammas, B. Tretarre, M. Colonna, S. Plouvier, T. D’Almeida, F. Molinié, A. Cowppli-Bony, S. Bara, G. Defossez, B. LapÔtre-Ledoux, P. Grosclaude, L. Daubisse-Marliac, S. Luttmann, R. Stabenow, A. Nennecke, J. Kieschke, S. Zeissig, B. Holleczek, A. Katalinic, H. Birgisson, D. Murray, P.M. Walsh, G. Mazzoleni, F. Vittadello, F. Cuccaro, R. Galasso, G. Sampietro, S. Rosso, C. Gasparotti, G. Maifredi, M. Ferrante, R. Ragusa, M.L. Gambino, M. Lanzoni, P. Ballotari, E. Giacomazzi, S. Ferretti, A. Caldarella, G. Manneschi, G. Gatta, M. Sant, P. Baili, F. Berrino, L. Botta, A. Trama, R. Lillini, A. Bernasconi, L. Bonfarnuzzo, C. Vener, F. Didoné, P. Lasalvia, G. Del Monego, L. Buratti, G. Tagliabue, D. Serraino, L. Dal Maso, R. Capocaccia, R. De Angelis, E. Demuru, C. Di Benedetto, S. Rossi, M. Santaquilani, S. Venanzi, M. Tallon, L. Boni, S. Iacovacci, V. Gennaro, A.G. Russo, F. Gervasi, G. Spagnoli, L. Cavalieri d’’Oro, M. Fusco, M.F. Vitale, M. Usala, W. Mazzucco, M. Michiara, G. Chiranda, G. Cascone, C.P. Rollo, L. Mangone, F. Falcini, R. Cavallo, D. Piras, A. Madeddu, F. Bella, A.C. Fanetti, S. Minerba, G. Candela, T. Scuderi, R.V. Rizzello, M. Rugge, A. Brustolin, S. Pildava, G. Smailyte, M. Azzopardi, T.B. Johannesen, J. Didkowska, U. Wojciechowska, M. Bielska-Lasota, A. Pais, J. Rodrigues, M.J. Bento, A. Miranda, V. Zadnik, T. Zagar, C. Sánchez-Contador Escudero, P. Franch Sureda, A. Lopez de Munain, M. De-La-Cruz, M.D. Rojas, A. Aleman, A. Vizcaino, R. Marcos-Gragera, A. Sanvisens, M.J. Sanchez, M.D. Chirlaque, A. Sanchez-Gil, M. Guevara, E. Ardanaz, A. Ameijide, C. Carulla, Y. Bergeron, C. Bouchardy, S. Mohsen Mousavi, P. Went, M. Blum, A. Bordoni, O. Visser, S. Stevens, J. Broggio, A. Gavin, D. Morrison, and D.W. Huws

Subjects
cancer prevalence, cancer registries, cancer survivors, cancer survivorship, EUROCARE, Europe, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

IntroductionComparable indicators on complete cancer prevalence are increasingly needed in Europe to support survivorship care planning. Direct measures can be biased by limited registration time and estimates are needed to recover long term survivors. The completeness index method, based on incidence and survival modelling, is the standard most validated approach.MethodsWithin this framework, we consider two alternative approaches that do not require any direct modelling activity: i) empirical indices derived from long established European registries; ii) pre-calculated indices derived from US-SEER cancer registries. Relying on the EUROCARE-6 study dataset we compare standard vs alternative complete prevalence estimates using data from 62 registries in 27 countries by sex, cancer type and registration time.ResultsFor tumours mostly diagnosed in the elderly the empirical estimates differ little from standard estimates (on average less than 5% after 10-15 years of registration), especially for low prognosis cancers. For early-onset cancers (bone, brain, cervix uteri, testis, Hodgkin disease, soft tissues) the empirical method may produce substantial underestimations of complete prevalence (up to 20%) even when based on 35-year observations. SEER estimates are comparable to the standard ones for most cancers, including many early-onset tumours, even when derived from short time series (10-15 years). Longer observations are however needed when cancer-specific incidence and prognosis differ remarkably between US and European populations (endometrium, thyroid or stomach).DiscussionThese results may facilitate the dissemination of complete prevalence estimates across Europe and help bridge the current information gaps.

Published
2023
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3. Clear Improvement in Real-World Chronic Myeloid Leukemia Survival: A Comparison With Randomized Controlled Trials

Author

Claudia Vener, Silvia Rossi, Pamela Minicozzi, Rafael Marcos-Gragera, Hélène A. Poirel, Marc Maynadié, Xavier Troussard, Gabriella Pravettoni, Roberta De Angelis, Milena Sant, the EUROCARE-6 Working Group, M. Hackl, E. Van Eycken, Z. Valerianova, M. Sekerija, P. Pavlou, L. Dušek, H. Storm, M. Mägi, K. Innos, N. Malila, J. Pitkäniemi, M. Velten, X. Troussard, A.M. Bouvier, V. Jooste, A.V. Guizard, G. Launoy, S. Dabakuyo Yonli, M. Maynadié, A.S. Woronoff, J.B. Nousbaum, G. Coureau, A. Monnereau, I. Baldi, K. Hammas, B. Tretarre, M. Colonna, S. Plouvier, T. D’Almeida, F. Molinié, A. Cowppli-Bony, S. Bara, C. Schvartz, G. Defossez, B. Lapôtre-Ledoux, P. Grosclaude, S. Luttmann, R. Stabenow, A. Nennecke, J. Kieschke, S. Zeissig, B. Holleczek, A. Katalinic, H. Birgisson, D. Murray, P.M. Walsh, G. Mazzoleni, F. Vittadello, F. Cuccaro, R. Galasso, G. Sampietro, S. Rosso, M. Magoni, M. Ferrante, A. Sutera Sardo, M.L. Gambino, P. Ballotari, E. Giacomazzi, S. Ferretti, A. Caldarella, G. Manneschi, G. Gatta, M. Sant, P. Baili, F. Berrino, L. Botta, A. Trama, R. Lillini, A. Bernasconi, S. Bonfarnuzzo, C. Vener, F. Didonè, P. Lasalvia, G. Del Monego, M.C. Magri, L. Buratti, D. Serraino, L. Dal Maso, R. Capocaccia, R. De Angelis, E. Demuru, C. Di Benedetto, S. Rossi, M. Santaquilani, S. Venanzi, R.A. Filiberti, S. Iacovacci, V. Gennaro, A.G. Russo, G. Spagnoli, L. Cavalieri d’Oro, M. Fusco, M.F. Vitale, M. Usala, F. Vitale, M. Michiara, G. Chiranda, G. Cascone, E. Spata, L. Mangone, F. Falcini, R. Cavallo, D. Piras, A. Madeddu, F. Bella, A.C. Fanetti, S. Minerba, G. Candela, T. Scuderi, R.V. Rizzello, F. Stracci, G. Tagliabue, M. Rugge, A. Brustolin, S. Pildava, G. Smailyte, M. Azzopardi, T.B. Johannesen, J. Didkowska, U. Wojciechowska, M. Bielska-Lasota, A. Pais, J.L. Pontes, A. Miranda, C. Safaei Diba, V. Zadnik, T. Zagar, C. Sánchez-Contador Escudero, P. Franch Sureda, A. Lopez de Munain, M. De-La-Cruz, M.D. Rojas, A. Aleman, A. Vizcaino, R. Marcos-Gragera, M.J. Sanchez, M.D. Chirlaque, M. Guevara Eslava, E. Ardanaz, J. Galceran, M. Carulla, Y. Bergeron, C. Bouchardy, S. Mohsen Mousavi, A. Bordoni, O. Visser, J. Rashbass, A. Gavin, D. Morrison, and D. W. Huws

Subjects
cancer registries, chronic myeloid leukemia (CML), randomized controlled trials (RCTs), real-world data, survival, Europe, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Tyrosine kinase inhibitors (TKIs) have been improving the prognosis of patients with chronic myeloid leukemia (CML), but there are still large differences in survival among European countries. This raises questions on the added value of results from population-based studies, which use real-world data, compared to results of randomized controlled trials (RCTs) involving patients with CML. There are also questions about the extent of the findings on RCTs effectiveness for patients in the general population. We compare survival data extracted from our previous systematic review and meta-analysis of CML RCTs with the latest updated population-based survival data of EUROCARE-6, the widest collaborative study on cancer survival in Europe. The EUROCARE-6 CML survival estimated in patients (15–64 years) diagnosed in 2000–2006 vs. 2007–2013 revealed that the prognostic improvement highlighted by RCTs was confirmed in real-world settings, too. The study shows, evaluating for the first time all European regions, that the optimal outcome figures obtained in controlled settings for CML are also achievable (and indeed achieved) in real-world settings with prompt introduction of TKIs in daily clinical practice. However, some differences still persist, particularly in Eastern European countries, where overall survival values are lower than elsewhere, probably due to a delayed introduction of TKIs. Our results suggest an insufficient adoption of adequate protocols in daily clinical practice in those countries where CML survival values remain lower in real life than the values obtained in RCTs. New high-resolution population-based studies may help to identify failures in the clinical pathways followed there.

Published
2022
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4. Learning debiased graph representations from the OMOP common data model for synthetic data generation.

Author

Schulz, Nicolas Alexander, Carus, Jasmin, Wiederhold, Alexander Johannes, Johanns, Ole, Peters, Frederik, Rath, Natalie, Rausch, Katharina, Holleczek, Bernd, Katalinic, Alexander, Nennecke, Alice, Kusche, Henrik, Heinrichs, Vera, Eberle, Andrea, Luttmann, Sabine, Abnaof, Khalid, Kim-Wanner, Soo-Zin, Handels, Heinz, Germer, Sebastian, Halber, Marco, and Richter, Martin

Subjects
REPRESENTATIONS of graphs, ELECTRONIC health record standards, MEDICAL informatics, DATA modeling, NURSING informatics, MARKOV processes
Abstract

Background: Generating synthetic patient data is crucial for medical research, but common approaches build up on black-box models which do not allow for expert verification or intervention. We propose a highly available method which enables synthetic data generation from real patient records in a privacy preserving and compliant fashion, is interpretable and allows for expert intervention. Methods: Our approach ties together two established tools in medical informatics, namely OMOP as a data standard for electronic health records and Synthea as a data synthetization method. For this study, data pipelines were built which extract data from OMOP, convert them into time series format, learn temporal rules by 2 statistical algorithms (Markov chain, TARM) and 3 algorithms of causal discovery (DYNOTEARS, J-PCMCI+, LiNGAM) and map the outputs into Synthea graphs. The graphs are evaluated quantitatively by their individual and relative complexity and qualitatively by medical experts. Results: The algorithms were found to learn qualitatively and quantitatively different graph representations. Whereas the Markov chain results in extremely large graphs, TARM, DYNOTEARS, and J-PCMCI+ were found to reduce the data dimension during learning. The MultiGroupDirect LiNGAM algorithm was found to not be applicable to the problem statement at hand. Conclusion: Only TARM and DYNOTEARS are practical algorithms for real-world data in this use case. As causal discovery is a method to debias purely statistical relationships, the gradient-based causal discovery algorithm DYNOTEARS was found to be most suitable. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Socioeconomic deprivation and cancer survival in a metropolitan area: An analysis of cancer registry data from Hamburg, Germany

Author

Lina Jansen, Cynthia Erb, Alice Nennecke, Isabelle Finke, Ron Pritzkuleit, Bernd Holleczek, and Hermann Brenner

Subjects
Public aspects of medicine, RA1-1270
Abstract

Background: Few studies have investigated socioeconomic inequalities within cities. Yet, such analyses are particularly important given the increasing international trend to urbanization. Here we investigated area-based socioeconomic inequalities in cancer survival in Hamburg, a port city in the North of Germany (population: 1.84 million people). Methods: Patients with a diagnosis of colorectal, lung, female breast, and prostate cancer in 2004–2018 (follow-up until 31.12.2018) and registered in the Hamburg cancer registry were included. Area-based socioeconomic deprivation on urban district level was assigned to the patients and grouped in five quintiles. Relative survival in 2014–2018 was calculated using the period approach. Trend analyses between 2004 and 2018 were conducted. Relative excess risks adjusted for age and stage were computed with model-based period analyses. Findings: For the 73,106 included patients, age-standardized 5-year relative survival in 2014–2018 decreased with increasing deprivation with significant differences between the most and least deprived group of 14·7 (prostate), 10·8 (colorectal), 8·0 (breast), and 2·5 (lung) percent units. Standardization by cancer stage decreased the difference for prostate cancer to 8·5 percent units and for breast cancer to 3·6 percent units but had only a minor effect for colorectal and lung cancer. Similar socioeconomic inequalities were already present in 2004–08. Interpretation: Strong socioeconomic inequalities in cancer survival were observed in Hamburg, which could be partly explained by differences in the stage distribution. Further research including information on screening participation as well as information on cancer care are important to further understand and finally overcome these inequalities. Funding: German Cancer Aid.

Published
2021
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7. Population-Based Clinical Cancer Registration in Germany

Author

Katalinic, Alexander, primary, Halber, Marco, additional, Meyer, Martin, additional, Pflüger, Maren, additional, Eberle, Andrea, additional, Nennecke, Alice, additional, Kim-Wanner, Soo-Zin, additional, Hartz, Tobias, additional, Weitmann, Kerstin, additional, Stang, Andreas, additional, Justenhoven, Christina, additional, Holleczek, Bernd, additional, Piontek, Daniela, additional, Wittenberg, Ian, additional, Heßmer, Annika, additional, Kraywinkel, Klaus, additional, Spix, Claudia, additional, and Pritzkuleit, Ron, additional

Published
2023
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8. Persisting Deficits in Health-Related Quality of Life of Colorectal Cancer Survivors 14–24 Years Post-Diagnosis: A Population-Based Study

Author

Thong, Melissa S. Y., primary, Doege, Daniela, additional, Weißer, Linda, additional, Koch-Gallenkamp, Lena, additional, Jansen, Lina, additional, Bertram, Heike, additional, Eberle, Andrea, additional, Holleczek, Bernd, additional, Nennecke, Alice, additional, Waldmann, Annika, additional, Zeissig, Sylke Ruth, additional, Brenner, Hermann, additional, and Arndt, Volker, additional

Published
2023
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9. Trends in survival of chronic lymphocytic leukemia patients in Germany and the USA in the first decade of the twenty-first century

Author

Dianne Pulte, Felipe A. Castro, Lina Jansen, Sabine Luttmann, Bernd Holleczek, Alice Nennecke, Meike Ressing, Alexander Katalinic, Hermann Brenner, and GEKID Cancer Survival Working Group

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Recent population-based studies in the United States of America (USA) and other countries have shown improvements in survival for patients with chronic lymphocytic leukemia (CLL) diagnosed in the early twenty-first century. Here, we examine the survival for patients diagnosed with CLL in Germany in 1997–2011. Methods Data were extracted from 12 cancer registries in Germany and compared to the data from the USA. Period analysis was used to estimate 5- and 10-year relative survival (RS). Results Five- and 10-year RS estimates in 2009–2011 of 80.2 and 59.5 %, respectively, in Germany and 82.4 and 64.7 %, respectively, in the USA were observed. Overall, 5-year RS increased significantly in Germany and the difference compared to the survival in the USA which slightly decreased between 2003–2005 and 2009–2011. However, age-specific analyses showed persistently higher survival for all ages except for 15–44 in the USA. In general, survival decreased with age, but the age-related disparity was small for patients younger than 75. In both countries, 5-year RS was >80 % for patients less than 75 years of age but

Published
2016
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10. Verknüpfung von Abrechnungsdaten gesetzlicher Krankenkassen mit Daten epidemiologischer Krebsregister: länderspezifische Möglichkeiten und Limitationen

Author

Iris Pigeot, Brenda Bongaerts, Andrea Eberle, Alexander Katalinic, Joachim Kieschke, Sabine Luttmann, Martin Meyer, Alice Nennecke, Wolfgang Rathmann, Roland Stabenow, Heide Wilsdorf-Köhler, Bianca Kollhorst, and Tammo Reinders

Subjects
Public Health, Environmental and Occupational Health, Indirect linkage, FAIR principles, GePaRD, FAIR-Prinzipien, Indirektes Linkage, Record linkage, Direktes Linkage, Record Linkage, Direct linkage
Abstract

HINTERGRUND: In den letzten Jahren wird verstärkt gefordert, Forschungsdaten gemäß den sog. FAIR-Prinzipien für eine Nachnutzung aufzubereiten. Dadurch könnten zukünftige Projekte auf einer breiteren Datengrundlage durchgeführt sowie durch Verknüpfung verschiedener Datenquellen neue Fragestellungen untersucht werden. FRAGESTELLUNG: Eruiert werden soll, inwieweit Abrechnungsdaten gesetzlicher Krankenversicherungen mit den Daten der Landeskrebsregister (LKR) überregional verknüpft werden können, um die in den Abrechnungsdaten fehlenden Informationen zu Krebserkrankungen ergänzen und die Validität der dortigen Angaben zur Tumordiagnose beurteilen zu können. Der Fokus liegt dabei auf der Beschreibung der länderspezifischen Anforderungen für einen solchen Datenabgleich. MATHERIAL UND METHODEN: Als Datenquellen wurden die Pharmakoepidemiologische Forschungsdatenbank GePaRD des Leibniz-Instituts für Präventionsforschung und Epidemiologie – BIPS und sechs Krebsregister herangezogen. Zur Verknüpfung wurden vergleichend das logistisch aufwendige direkte Linkage- und ein weniger aufwendiges indirektes Linkage-Verfahren angewandt. Dazu mussten für GePaRD und für jedes LKR die Genehmigungen der jeweils zuständigen Behörde eingeholt werden. ERGEBNISSE: Hinsichtlich der Verknüpfung von LKR-Daten mit GePaRD zeigten sich gravierende Unterschiede in der Datenbereitstellung (vollständige Ablehnung bis hin zu einer unkomplizierten Umsetzung). DISKUSSION: In Deutschland müssen einheitliche Rahmenbedingungen geschaffen werden, um eine angemessene Nachnutzung und eine Verknüpfung von personenbezogenen Gesundheitsdaten zu Forschungszwecken im Sinne der FAIR-Prinzipien zu ermöglichen. Bezüglich der Verknüpfung von LKR-Daten mit anderen Datenquellen könnte das neue Gesetz zur Zusammenführung von Krebsregisterdaten Abhilfe schaffen. BACKGROUND: In recent years, there has been an increasing demand for the reuse of research data in accordance with the so-called FAIR principles. This would allow researchers to conduct projects on a broader data basis and to investigate new research questions by linking different data sources. OBJECTIVES: We explored if nationwide linking of claims data from statutory health insurances (SHI) with data from population-based cancer registries can be used to obtain additional information on cancer that is missing in claims data and to assess the validity of SHI tumour diagnoses. This paper focuses on describing the specific requirements of German federal states for such data linkage. MATERIALS AND METHODS: The Pharmacoepidemiological Research Database GePaRD at the Leibniz Institute for Prevention Research and Epidemiology – BIPS and six cancer registries were used as data sources. The logistically complex direct linkage was compared with a less complex indirect linkage. For this purpose, permission had to be obtained for GePaRD and for each cancer registry from the respective responsible authority. RESULTS: Regarding the linkage of cancer registry data with GePaRD, the cancer registries showed profound differences in the modalities for data provision, ranging from a complete rejection to an uncomplicated implementation of linkage procedures. DISCUSSION: In Germany, a consistent legal framework is needed to adequately enable the reuse and record linkage of personal health data for research purposes according to the FAIR principles. The new law on the consolidation of cancer registry data could provide a remedy regarding the linkage of cancer registry data with other data sources.

Published
2021

11. Mundhöhlen- und Pharynxkarzinome: Inzidenz, Mortalität und Überleben in Deutschland

Author

Ron Pritzkuleit, Lina Jansen, Peter K. Plinkert, Karim Zaoui, Alice Nennecke, Bernd Holleczek, Annika Waldmann, Volker Arndt, Julius Moratin, and Jürgen Hoffmann

Subjects
Mouth neoplasm, Gynecology, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, 030220 oncology & carcinogenesis, Incidence (epidemiology), Pharyngeal cancer, Public Health, Environmental and Occupational Health, medicine, 030212 general & internal medicine, business
Abstract

Zusammenfassung Hintergrund Die Gruppe der Lippen‑, Mundhöhlen- und Pharynxkarzinome (ICD-10: C00–C14) beschreibt eine heterogene Gruppe bösartiger Tumoren, deren Inzidenz, Mortalität und Überleben sich nach Entität stark unterscheiden. Ziel der Arbeit Diese Arbeit gibt eine detaillierte Übersicht epidemiologischer Maßzahlen für diese Tumorentitäten unter Berücksichtigung der Heterogenität bezüglich Alter, Geschlecht, Lokalisation und Stadium. Material und Methoden Inzidenz- und Mortalitätsdaten für Deutschland für die Jahre 1999–2016 wurden aus der interaktiven Datenbank des Zentrums für Krebsregisterdaten (ZfKD) extrahiert. Alters- und Stadienverteilungen und altersstandardisiertes relatives 5‑Jahres-Überleben wurden auf dem gepoolten ZfKD-Datensatz (Diagnosejahre 1999–2017) berechnet. Ergebnisse Im Jahr 2016 lagen die Inzidenz und Mortalität für alle Entitäten insgesamt bei 17,6 bzw. 7,0 pro 100.000 Männern und 6,5 bzw. 1,8 pro 100.000 Frauen. Das relative 5‑Jahres-Überleben für 2015–2017 lag bei 53 % bzw. 63 %. Es zeigten sich deutliche Unterschiede in der Überlebensrate und in der Alters- und Stadienverteilung zwischen den Entitäten. Im zeitlichen Verlauf zeigte sich ein Anstieg des Alters bei Diagnose, insbesondere bei Männern, aber keine Veränderung in der Stadienverteilung. Trotzdem stieg das relative 5‑Jahres-Überleben zwischen 1999–2002 und 2013–2017 von 45 % (Männer) bzw. 59 % (Frauen) auf 52 % bzw. 63 %. Diskussion Die starke Heterogenität der untersuchten Tumoren verdeutlicht die Notwendigkeit einer nach Geschlechtern und Lokalisationen getrennten Betrachtung für eine aussagekräftige Interpretation der epidemiologischen Kennzahlen. Mit Ausbau der klinischen Krebsregistrierung werden in Zukunft zusätzliche Analysen unter Einbezug weiterer wichtiger klinischer Faktoren möglich sein.

Published
2021

12. Distress mediates the relationship between cognitive appraisal of medical care and benefit finding/posttraumatic growth in long‐term cancer survivors

Author

Ron Pritzkuleit, Daniela Doege, Melissa S Y Thong, Zhunzhun Liu, Bernd Holleczek, Annika Waldmann, Lena Koch-Gallenkamp, Alice Nennecke, Sylke Ruth Zeißig, Andrea Eberle, Heike Bertram, Volker Arndt, APH - Aging & Later Life, and APH - Mental Health

Subjects
Cancer Research, Population, Psychological intervention, benefit finding, posttraumatic growth, Medical care, Stress Disorders, Post-Traumatic, Cognition, Neoplasms, Adaptation, Psychological, medicine, Humans, cancer survivors, Survivors, education, education.field_of_study, business.industry, Posttraumatic growth, distress, Cancer, moderator-mediator, medicine.disease, Moderation, Distress, Oncology, Moderator-mediator, Cognitive appraisal, Benefit finding, Cancer survivors, medical care, cognitive appraisal, business, Posttraumatic Growth, Psychological, Clinical psychology
Abstract

Background The objective of this study was to ascertain long-term cancer survivors' (LTCS') appraisal of medical care and how these perceptions may influence their health and well-being, including benefit finding (BF) and posttraumatic growth (PTG). Methods In total, 6952 LTCS from a multiregional population-based study in Germany completed the Benefit Finding Scale, the Posttraumatic Growth Inventory, the Questionnaire on Stress in Cancer, and self-designed questions on cognitive appraisal of medical care. The authors explored the mediating role of distress between medical care appraisal and BF and PTG and the possible moderation of time since diagnosis in this relationship. Results LTCS' medical care appraisals ("no unresolved/untreated symptoms," "satisfaction with cancer care," and "satisfaction with care for other diseases") were positively associated with BF. PTG was positively associated with "no unresolved/untreated symptoms" and negatively associated with "satisfaction with care for other diseases." Cancer distress partially mediated the associations between appraisals of medical care and BF, between "no unresolved/untreated symptoms" and PTG and between "satisfaction with care for other diseases" and PTG; whereas it totally mediated the association between "satisfaction with cancer care" and PTG. Time was a significant moderator in the model; the negative indirect effect of cognitive appraisal on BF and PTG through cancer distress weakened with longer time since diagnosis. Conclusions Cancer survivors' medical care appraisal is associated with their perceptions of BF and PTG through distress. Therefore, distress screening could be part of the regular workup to identify distressed cancer survivors who are not satisfied with medical care; these survivors may benefit from interventions to reduce distress and increase BF and PTG.

Published
2021

14. Clear Improvement in Real-World Chronic Myeloid Leukemia Survival: A Comparison With Randomized Controlled Trials

Author

Vener, C., Rossi, S., Minicozzi, P., Marcos-Gragera, R., Poirel, H. A., Maynadie, M., Troussard, X., Pravettoni, G., De Angelis, R., Sant, M., Hackl, M., Van Eycken, E., Valerianova, Z., Sekerija, M., Pavlou, P., Dusek, L., Storm, H., Magi, M., Innos, K., Malila, N., Pitkaniemi, J., Velten, M., Bouvier, A. M., Jooste, V., Guizard, A. V., Launoy, G., Yonli, S. D., Woronoff, A. S., Nousbaum, J. B., Coureau, G., Monnereau, A., Baldi, I., Hammas, K., Tretarre, B., Colonna, M., Plouvier, S., D'Almeida, T., Molinie, F., Cowppli-Bony, A., Bara, S., Schvartz, C., Defossez, G., Lapotre-Ledoux, B., Grosclaude, P., Luttmann, S., Stabenow, R., Nennecke, A., Kieschke, J., Zeissig, S., Holleczek, B., Katalinic, A., Birgisson, H., Murray, D., Walsh, P. M., Mazzoleni, G., Vittadello, F., Cuccaro, F., Galasso, R., Sampietro, G., Rosso, S., Magoni, M., Ferrante, M., Sardo, A. S., Gambino, M. L., Ballotari, P., Giacomazzi, E., Ferretti, S., Caldarella, A., Manneschi, G., Gatta, G., Baili, P., Berrino, F., Botta, L., Trama, A., Lillini, R., Bernasconi, A., Bonfarnuzzo, S., Didone, F., Lasalvia, P., Del Monego, G., Magri, M. C., Buratti, L., Serraino, D., Dal Maso, L., Capocaccia, R., Demuru, E., Di Benedetto, C., Santaquilani, M., Venanzi, S., Filiberti, R. A., Iacovacci, S., Gennaro, V., Russo, A. G., Spagnoli, G., D'Oro, L. C., Fusco, M., Vitale, M. F., Usala, M., Vitale, F., Michiara, M., Chiranda, G., Cascone, G., Spata, E., Mangone, L., Falcini, F., Cavallo, R., Piras, D., Madeddu, A., Bella, F., Fanetti, A. C., Minerba, S., Candela, G., Scuderi, T., Rizzello, R. V., Stracci, F., Tagliabue, G., Rugge, M., Brustolin, A., Pildava, S., Smailyte, G., Azzopardi, M., Johannesen, T. B., Didkowska, J., Wojciechowska, U., Bielska-Lasota, M., Pais, A., Pontes, J. L., Miranda, A., Diba, C. S., Zadnik, V., Zagar, T., Escudero, C. S. -C., Sureda, P. F., de Munain, A. L., De-La-cruz, M., Rojas, M. D., Aleman, A., Vizcaino, A., Sanchez, M. J., Chirlaque, M. D., Eslava, M. G., Ardanaz, E., Galceran, J., Carulla, M., Bergeron, Y., Bouchardy, C., Mousavi, S. M., Bordoni, A., Visser, O., Rashbass, J., Gavin, A., Morrison, D., and Huws, D. W.

Subjects
Cancer Research, Survival, real-world data, randomized controlled trials (RCTs), tyrosine kinase inhibitor (TKI), population-based studies, Tyrosine kinase inhibitor (TKI), Randomized controlled trials (RCTs), survival, Real-world data, Europe, Oncology, cancer registries, chronic myeloid leukemia (CML), Chronic myeloid leukemia (CML), Cancer registries, Population-based studies
Abstract

This study was funded by the Compagnia di San Paolo, the Cariplo Foundation and the European Commission (grant number 801520 HP-JA-2017, Innovative Partnership for Action Against Cancer, iPAAC Joint Action). The sources of the funding played no role in designing the study, collecting, analyzing, or interpreting the data, writing the report, or deciding whether or not to submit the article for publication. This research was (partially) funded by Italian Ministry of Health "Ricerca Corrente" funds. Tyrosine kinase inhibitors (TKIs) have been improving the prognosis of patients with chronic myeloid leukemia (CML), but there are still large differences in survival among European countries. This raises questions on the added value of results from population-based studies, which use real-world data, compared to results of randomized controlled trials (RCTs) involving patients with CML. There are also questions about the extent of the findings on RCTs effectiveness for patients in the general population. We compare survival data extracted from our previous systematic review and meta-analysis of CML RCTs with the latest updated population-based survival data of EUROCARE-6, the widest collaborative study on cancer survival in Europe. The EUROCARE-6 CML survival estimated in patients (15-64 years) diagnosed in 2000-2006 vs. 2007-2013 revealed that the prognostic improvement highlighted by RCTs was confirmed in real-world settings, too. The study shows, evaluating for the first time all European regions, that the optimal outcome figures obtained in controlled settings for CML are also achievable (and indeed achieved) in real-world settings with prompt introduction of TKIs in daily clinical practice. However, some differences still persist, particularly in Eastern European countries, where overall survival values are lower than elsewhere, probably due to a delayed introduction of TKIs. Our results suggest an insufficient adoption of adequate protocols in daily clinical practice in those countries where CML survival values remain lower in real life than the values obtained in RCTs. New high-resolution population-based studies may help to identify failures in the clinical pathways followed there.

Published
2022

15. Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3): analysis of individual data from 258 cancer registries in 61 countries

Author

Naomi Ssenyonga, Charles Stiller, Kayo Nakata, Jaime Shalkow, Shelagh Redmond, Jean-Luc Bulliard, Fabio Girardi, Christine Fowler, Rafael Marcos-Gragera, Audrey Bonaventure, Nathalie Saint-Jacques, Pamela Minicozzi, Prithwish De, Miguel Rodríguez-Barranco, Siri Larønningen, Veronica Di Carlo, Margit Mägi, Mikhail Valkov, Karri Seppä, Dyfed Wyn Huws, Michel P Coleman, Claudia Allemani, Sabiha Bouzbid, Mokhtar Hamdi-Chérif, Lamia Kara, Kaouel Meguenni, Derbali Regagba, Sine Bayo, Traore Cheick Bougadari, Shyam Shunker Manraj, Karima Bendahhou, Akinade Ladipo, Olufemi Ogunbiyi, Nontuthuzelo Somdyala, María Agustina Chaplin, Florencia Moreno, Gladis Calabrano, Silvia Espinola, Beatriz Carballo Quintero, Rosalba Fita, Walter Laspada, Susana Ibañez, Carlos Lima, Allini Mafra Da Costa, Paulo César De Souza, Juliana Chaves, Cyntia Laporte, Maria Paula Curado, Jose Carlos de Oliveira, Claudia Veneziano, Donaldo Veneziano, Ana Beatriz Almeida, Maria Latorre, Gulnar Azevedo e Silva, Marise Rebelo, Marceli Santos, Juan Galaz, Mackarena Aparicio Aravena, Jocelyn Sanhueza Monsalve, Denise Herrmann, Solange Vargas, Victor Herrera, Claudia Uribe, Luis Eduardo Bravo, Luz Stella Garcia, Nelson Arias-Ortiz, Daniela Morantes, Daniel Jurado, María Yépez Chamorro, Sandra Delgado, Melissa Ramirez, Yaima Galán Alvarez, Priscila Torres, Fray Martínez-Reyes, Leyda Jaramillo, Rina Quinto, Jhoanna Castillo, Mariela Mendoza, Patricia Cueva, José Yépez, Bernard Bhakkan, Jacqueline Deloumeaux, Clarisse Joachim, Jonathan Macni, Rodolfo Carrillo, Jaime Shalkow Klincovstein, Rebeca Rivera Gomez, Patricia Perez, Ebert Poquioma, Guillermo Tortolero-Luna, Diego Zavala, Rafael Alonso, Enrique Barrios, Angela Eckstrand, Cindy Nikiforuk, Ryan Woods, Gail Noonan, Donna Turner, Eshwar Kumar, Bin Zhang, Jeff Dowden, Gregory Doyle, Gordon Walsh, Aniq Anam, Carol McClure, Kim Vriends, Christine Bertrand, Agnihotram Ramanakumar, Serena Kozie, Heather Stuart-Panko, Tara Freeman, Justin George, Rosa Avila, David O'Brien, Abby Holt, Lyn Almon, Kevin Ward, Sandy Kwong, Cyllene Morris, Randi Rycroft, Lloyd Mueller, Cathryn Phillips, Heather Brown, Betsy Cromartie, Julie Ruterbusch, Ann Schwartz, Gary Levin, Brad Wohler, Rana Bayakly, Scarlett Gomez, Meg McKinley, Rosemary Cress, Joni Davis, Brenda Hernandez, Christopher Johnson, Bozena Morawski, Laura Ruppert, Suzanne Bentler, Mary Charlton, Bin Huang, Thomas Tucker, Dennis Deapen, Lihua Liu, Mei-Chin Hsieh, Xiao-Cheng Wu, Molly Schwenn, Kimberly Stern, Susan Gershman, Richard Knowlton, Georgetta Alverson, Tamara Weaver, Jay Desai, Deirdre Rogers, Jeanette Jackson-Thompson, Debbi Lemons, Heather Zimmerman, Michelle Hood, Jenifer Roberts-Johnson, Whitney Hammond, Judith Rees, Karen Pawlish, Antoinette Stroup, Charles Key, Charles Wiggins, Amy Kahn, Maria Schymura, Soundarya Radhakrishnan, Chandrika Rao, Lynn Giljahn, Roberta Slocumb, Christy Dabbs, Raffaella Espinoza, Karen Aird, Todd Beran, Jim Rubertone, Stephen Slack, Junhie Oh, Tiffany Janes, Stephen Schwartz, Stephanie Chiodini, Deborah Hurley, Martin Whiteside, Saroj Rai, Melanie Williams, Kim Herget, Carol Sweeney, Alison Johnson, Mahesh Keitheri Cheteri, Patti Migliore Santiago, Steven Blankenship, Shawn Farley, Robert Borchers, Robin Malicki, Julia Espinoza, Joseph Grandpre, Brenda Edwards, Angela Mariotto, Hannah Weir, Reda Wilson, Ning Wang, Lei Yang, Jian-Shun Chen, Yu-Tong He, Guo-Hui Song, Xiao-Ping Gu, Dan Mei, Heng-Ming Ge, Tong-Hao Wu, Yan-Yan Li, De-Li Zhao, Feng Jin, Jian-Hua Zhang, Feng-Dong Zhu, Qian Junhua, Yan Lei Yang, Chun-Xiao Jiang, Wang Biao, Jian Wang, Qi-Long Li, He Yi, Xin Zhou, JianMei Dong, WeiWei Li, Fang-Xian Fu, Jian-Guo Chen, Jian Zhu, Yan-Hua Li, Yu-Qiang Lu, Min Fan, Su-Qin Huang, Guo-Ping Guo, Hua Zhaolai, Kuangrong Wei, Wan-Qing Chen, Wenqiang Wei, Hongmei Zeng, Anna Demetriou, Wai Kong Mang, Kai Cheong Ngan, Amal Kataki, Manigreeva Krishnatreya, Padmavathi Amma Jayalekshmi, Paul Sebastian, Preethi George, Aleyamma Mathew, Ambakumar Nandakumar, Reza Malekzadeh, Gholamreza Roshandel, Lital Keinan-Boker, Barbara Silverman, Hidemi Ito, Yuriko Koyanagi, Masako Sato, Fumio Tobori, Ichiro Nakata, Norihiro Teramoto, Masakazu Hattori, Yasuharu Kaizaki, Fumitaka Moki, Hiromi Sugiyama, Mai Utada, Makiko Nishimura, Keiichi Yoshida, Katsuki Kurosawa, Yuji Nemoto, Hiroto Narimatsu, Masahiko Sakaguchi, Seiki Kanemura, Michiko Naito, Rintaro Narisawa, Isao Miyashiro, Daisuke Mori, Mayuko Yoshitake, Izumi Oki, Norimasa Fukushima, Akiko Shibata, Keiichiro Iwasa, Chie Ono, Tomohiro Matsuda, Omar Nimri, Kyu-Won Jung, Young-Joo Won, Eiman Alawadhi, Amani Elbasmi, Azizah Ab Manan, Farzaana Adam, Erdenekhuu Nansalmaa, Undarmaa Tudev, Chimedsuren Ochir, Al Hareth Al Khater, Mufid El Mistiri, Gek Hsiang Lim, Yik Ying Teo, Chun-Ju Chiang, Wen-Chung Lee, Rangsiya Buasom, Suleeporn Sangrajrang, Krittika Suwanrungruang, Patravoot Vatanasapt, Karnchana Daoprasert, Donsuk Pongnikorn, Atit Leklob, Somphob Sangkitipaiboon, Sarayut Geater, Hutcha Sriplung, Okan Ceylan, Iskender Kög, Oya Dirican, Tülay Köse, Tulın Gurbuz, Füsun Emine Karašahin, Duygu Turhan, Umut Aktaş, Yakup Halat, Sultan Eser, Cankut Yakut, Merve Altinisik, Yasar Cavusoglu, Ayşe Türkköylü, Nuršen Üçüncü, Monika Hackl, Anna Zborovskaya, Olga Aleinikova, Kris Henau, Liesbet Van Eycken, Trayan Atanasov, Zdravka Valerianova, Mario Šekerija, Ladislav Dušek, Miroslav Zvolský, Lina Steinrud Mørch, Hans Storm, Charlotte Wessel Skovlund, Kaire Innos, Nea Malila, Jérémie Jégu, Michel Velten, Edouard Cornet, Xavier Troussard, Anne-Marie Bouvier, Anne-Valérie Guizard, Véronique Bouvier, Guy Launoy, Sandrine Dabakuyo Yonli, Marie-Laure Poillot, Marc Maynadié, Morgane Mounier, Lina Vaconnet, Anne-Sophie Woronoff, Mélanie Daoulas, Michel Robaszkiewicz, Jacqueline Clavel, Claire Poulalhon, Emmanuel Desandes, Brigitte Lacour, Isabelle Baldi, Camille Pouchieu, Brice Amadeo, Gaëlle Coureau, Alain Monnereau, Magali Audoin, Tania D'Almeida, Séverine Boyer, Karima Hammas, Brigitte Trétarre, Marc Colonna, Patricia Delafosse, Sandrine Plouvier, Anne Cowppli-Bony, Florence Molinié, Simona Bara, Olivier Ganry, Bénédicte Lapôtre-Ledoux, Laetitia Daubisse-Marliac, Nadine Bossard, Jacques Estève, Zoé Uhry, Roland Stabenow, Heide Wilsdorf-Köhler, Andrea Eberle, Sabine Luttmann, Imma Löhden, Alice Nennecke, Joachim Kieschke, Eunice Sirri, Christina Justenhoven, Sylke Zeissig, Bernd Holleczek, Nora Eisemann, Alexander Katalinic, Rachelle Asquez, Vijay Kumar, Eleni Petridou, Elínborg Ólafsdóttir, Laufey Tryggvadóttir, Deirdre Murray, Paul Walsh, Hildrun Sundseth, Guido Mazzoleni, Fabio Vittadello, Enzo Coviello, Francesco Cuccaro, Rocco Galasso, Giuseppe Sampietro, Michele Magoni, Antonino Ardizzone, Angelo D'Argenzio, Alessia Anna Di Prima, Antonella Ippolito, Anna Maria Lavecchia, Antonella Sutera Sardo, Gemma Gola, Paola Ballotari, Erica Giacomazzi, Stefano Ferretti, Luigino Dal Maso, Diego Serraino, Maria Vittoria Celesia, Rosa Angela Filiberti, Fabio Pannozzo, Anna Melcarne, Fabrizio Quarta, Anita Andreano, Antonio Giampiero Russo, Giuliano Carrozzi, Claudia Cirilli, Luca Cavalieri d'Oro, Magda Rognoni, Mario Fusco, Maria Francesca Vitale, Mario Usala, Rosanna Cusimano, Walter Mazzucco, Maria Michiara, Paolo Sgargi, Lorenza Boschetti, Giorgio Chiaranda, Pietro Seghini, Milena Maule, Franco Merletti, Eugenia Spata, Rosario Tumino, Pamela Mancuso, Massimo Vicentini, Tiziana Cassetti, Romano Sassatelli, Fabio Falcini, Stefania Giorgetti, Anna Luisa Caiazzo, Rossella Cavallo, Daniela Piras, Francesca Bella, Anselmo Madeddu, Anna Clara Fanetti, Sergio Maspero, Simona Carone, Antonia Mincuzzi, Giuseppa Candela, Tiziana Scuderi, Maria Adalgisa Gentilini, Roberto Rizzello, Stefano Rosso, Roberto Zanetti, Adele Caldarella, Teresa Intrieri, Fortunato Bianconi, Fabrizio Stracci, Paolo Contiero, Giovanna Tagliabue, Massimo Rugge, Manuel Zorzi, Simonetta Beggiato, Angelita Brustolin, Roberta De Angelis, Gemma Gatta, Anita Maurina, Marija Oniščuka, Mohsen Mousavi, Nadezda Lipunova, Ieva Vincerzevskienė, Dominic Agius, Neville Calleja, Sabine Siesling, Otto Visser, Tom Johannesen, Maciej Trojanowski, Tomasz Mierzwa, Jadwiga Rachtan, Kamila Kępska, Beata Kościańska, Joanna Wójcik-Tomaszewska, Marcin Motnyk, Anna Gos, Magdalena Bielska-Lasota, Joanna Didkowska, Urszula Wojciechowska, Gonçalo Forjaz de Lacerda, Raul Rego, Branca Carrito, Ana Pais, Maria José Bento, Jessica Rodrigues, Antonio Lourenço, Alexandra Mayer-da-Silva, Luminita Blaga, Daniela Coza, Lubov Gusenkova, Olga Lazarevich, Olga Prudnikova, Dmitri Mikhailovich Vjushkov, Alla Egorova, Andrey Orlov, Lidiya Pikalova, Lilia Zhuikova, Juraj Adamcik, Chakameh Safaei Diba, Vesna Zadnik, Tina Zagar, Marta De-La-Cruz, Arantza Lopez-de-Munain, Araceli Aleman, Dolores Rojas, Rosario Jiménez Chillarón, Ana Isabel Marcos Navarro, Montse Puigdemont, María-José Sánchez Perez, Paula Franch Sureda, Maria Ramos Montserrat, Maria Dolores Chirlaque López, Antonia Sánchez Gil, Eva Ardanaz, Marcela Guevara, Adela Cañete-Nieto, Rafael Peris-Bonet, Marià Carulla, Jaume Galceran, Fernando Almela, Consol Sabater, Staffan Khan, David Pettersson, Paul Dickman, Katharina Staehelin, Benjamin Struchen, Christian Herrmann, Seyed Mohsen Mousavi, Céline Egger Hayoz, Christine Bouchardy, Robin Schaffar, Philip Went, Manuela Maspoli-Conconi, Claudia Kuehni, Andrea Bordoni, Laura Ortelli, Arnaud Chiolero, Isabelle Konzelmann, Sabine Rohrmann, Miriam Wanner, John Broggio, Jem Rashbass, Deirdre Fitzpatrick, Anna Gavin, David Morrison, Catherine Thomson, Giles Greene, Dyfed Huws, Michel Coleman, Melissa Matz, Natalia Sanz, Richard Stephens, Elizabeth Chalker, Mirka Smith, Jessica Gugusheff, Hui You, Shu Qin Li, Sarah Dugdale, Julie Moore, Shoni Philpot, Rhonda Pfeiffer, Helen Thomas, Bruna Silva Ragaini, Alison Venn, Sue Evans, Luc Te Marvelde, Vedrana Savietto, Richard Trevithick, David Currow, Chris Lewis, Ssenyonga, Naomi, Stiller, Charle, Nakata, Kayo, Shalkow, Jaime, Redmond, Sheilagh, Bulliard, Jean-Luc, Girardi, Fabio, Fowler, Christine, Marcos-Gragera, Raphael, Bonaventure, Audrey, Saint-Jacques, Nathalie, Minicozzi, Pamela, De, Prithwish, Rodríguez-Barranco, Miguel, Larønningen, Siri, Di Carlo, Veronica, Mägi, Margit, Valkov, Mikhail, Seppä, Karri, Wyn Huws, Dyfed, Coleman, Michel P, Allemani, Claudia, and Mazzucco, Walter

Subjects
Adolescent, Australia, 610 Medicine & health, lymphoma, Settore MED/42 - Igiene Generale E Applicata, survival, United States, Europe, Leukemia, Myeloid, Acute, Young Adult, children, population-based/cancer registry, 360 Social problems & social services, survival, leukemia, cancer registry, Hematologic Neoplasms, leukaemia, Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology, cancer, Humans, Registries, haematological malignancy, Child
Abstract

BACKGROUND Leukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0-14 years) and adults (aged 15-99 years) diagnosed with a haematological malignancy during 2000-14 in 61 countries. Here, we aimed to examine worldwide trends in survival from leukaemia, by age and morphology, in young patients (aged 0-24 years). METHODS We analysed data from 258 population-based cancer registries in 61 countries participating in CONCORD-3 that submitted data on patients diagnosed with leukaemia. We grouped patients by age as children (0-14 years), adolescents (15-19 years), and young adults (20-24 years). We categorised leukaemia subtypes according to the International Classification of Childhood Cancer (ICCC-3), updated with International Classification of Diseases for Oncology, third edition (ICD-O-3) codes. We estimated 5-year net survival by age and morphology, with 95% CIs, using the non-parametric Pohar-Perme estimator. To control for background mortality, we used life tables by country or region, single year of age, single calendar year and sex, and, where possible, by race or ethnicity. All-age survival estimates were standardised to the marginal distribution of young people with leukaemia included in the analysis. FINDINGS 164 563 young people were included in this analysis: 121 328 (73·7%) children, 22 963 (14·0%) adolescents, and 20 272 (12·3%) young adults. In 2010-14, the most common subtypes were lymphoid leukaemia (28 205 [68·2%] patients) and acute myeloid leukaemia (7863 [19·0%] patients). Age-standardised 5-year net survival in children, adolescents, and young adults for all leukaemias combined during 2010-14 varied widely, ranging from 46% in Mexico to more than 85% in Canada, Cyprus, Belgium, Denmark, Finland, and Australia. Individuals with lymphoid leukaemia had better age-standardised survival (from 43% in Ecuador to ≥80% in parts of Europe, North America, Oceania, and Asia) than those with acute myeloid leukaemia (from 32% in Peru to ≥70% in most high-income countries in Europe, North America, and Oceania). Throughout 2000-14, survival from all leukaemias combined remained consistently higher for children than adolescents and young adults, and minimal improvement was seen for adolescents and young adults in most countries. INTERPRETATION This study offers the first worldwide picture of population-based survival from leukaemia in children, adolescents, and young adults. Adolescents and young adults diagnosed with leukaemia continue to have lower survival than children. Trends in survival from leukaemia for adolescents and young adults are important indicators of the quality of cancer management in this age group. FUNDING Children with Cancer UK, the Institut National du Cancer, La Ligue Contre le Cancer, Centers for Disease Control and Prevention, Swiss Re, Swiss Cancer Research foundation, Swiss Cancer League, Rossy Family Foundation, US National Cancer Institute, and the American Cancer Society.

Published
2022

16. Clinical and sociodemographic determinants of disease-specific health-related quality of life in long-term breast cancer survivors

Author

Daniela Doege, Melissa S. Y. Thong, Lena Koch-Gallenkamp, Heike Bertram, Andrea Eberle, Bernd Holleczek, Alice Nennecke, Ron Pritzkuleit, Annika Waldmann, Sylke R. Zeissig, Hermann Brenner, Volker Arndt, Medical Psychology, APH - Aging & Later Life, and APH - Mental Health

Subjects
Disease-specific issues, Quality of life, Cancer Research, Adverse effects, Breast cancer survivors, Breast Neoplasms, Hair loss, General Medicine, Mastectomy, Segmental, humanities, Body image, Oncology, Cancer Survivors, Sexuality, Surveys and Questionnaires, Humans, Female, Mastectomy
Abstract

Purpose It is important to monitor disease-specific health-related quality of life (HRQoL) in breast cancer (BC) survivors to identify potential unmet supportive care needs. However, previous studies were characterized by small samples of mostly short-term survivors and were limited to certain age ranges, stages and/or treatments. Methods We used data from 3045 long-term BC survivors (5–15 years post-diagnosis) recruited in a German multi-regional population-based study. We assessed disease-specific HRQoL with the EORTC QLQ-BR23, scoring from 0 to 100. Differences in functioning and symptoms according to age at survey, self-reported treatments, stage, and disease status (disease-free vs. active disease) were assessed with multiple regression. Active disease was defined as any self-report of recurrence, metastasis or second primary cancer after the index cancer. Results Older BC survivors reported a higher body image and a better future perspective, but lower sexual functioning. Survivors aged 30–49 years who had breast-conserving therapy or mastectomy with breast reconstruction reported a better body image compared to those who had mastectomy only. We also found differences in symptoms according to treatments in some age groups. Stage at diagnosis was not associated with HRQoL overall and in most age subgroups. Disease-free BC survivors aged 30–79 years reported a better future perspective and less systemic therapy side effects than those with active disease. Conclusion Several treatment-associated symptoms and functioning detriments were found 5–15 years after diagnosis. The results emphasize the need of a comprehensive, individualized survivorship care, recognizing differential needs of long-term BC survivors according to age, treatment modalities, and disease status.

Published
2022

17. Socioeconomic deprivation and cancer survival in a metropolitan area: An analysis of cancer registry data from Hamburg, Germany

Author

Bernd Holleczek, Isabelle Finke, Ron Pritzkuleit, Alice Nennecke, Hermann Brenner, Cynthia Erb, and Lina Jansen

Subjects
education.field_of_study, Relative survival, business.industry, Health Policy, Population, Cancer, medicine.disease, Cancer registry, Prostate cancer, Breast cancer, Oncology, Internal Medicine, medicine, Public aspects of medicine, RA1-1270, Lung cancer, business, education, Socioeconomic status, Research Paper, Demography
Abstract

Background Few studies have investigated socioeconomic inequalities within cities. Yet, such analyses are particularly important given the increasing international trend to urbanization. Here we investigated area-based socioeconomic inequalities in cancer survival in Hamburg, a port city in the North of Germany (population: 1.84 million people). Methods Patients with a diagnosis of colorectal, lung, female breast, and prostate cancer in 2004–2018 (follow-up until 31.12.2018) and registered in the Hamburg cancer registry were included. Area-based socioeconomic deprivation on urban district level was assigned to the patients and grouped in five quintiles. Relative survival in 2014–2018 was calculated using the period approach. Trend analyses between 2004 and 2018 were conducted. Relative excess risks adjusted for age and stage were computed with model-based period analyses. Findings For the 73,106 included patients, age-standardized 5-year relative survival in 2014–2018 decreased with increasing deprivation with significant differences between the most and least deprived group of 14·7 (prostate), 10·8 (colorectal), 8·0 (breast), and 2·5 (lung) percent units. Standardization by cancer stage decreased the difference for prostate cancer to 8·5 percent units and for breast cancer to 3·6 percent units but had only a minor effect for colorectal and lung cancer. Similar socioeconomic inequalities were already present in 2004–08. Interpretation Strong socioeconomic inequalities in cancer survival were observed in Hamburg, which could be partly explained by differences in the stage distribution. Further research including information on screening participation as well as information on cancer care are important to further understand and finally overcome these inequalities. Funding German Cancer Aid .

Published
2021

18. Treatment challenges in and outside a specialist network setting: Pancreatic neuroendocrine tumours

Author

Panagis M. Lykoudis, Stefano Partelli, Francesca Muffatti, Martyn Caplin, Massimo Falconi, Giuseppe K. Fusai, Monika Hackl, Elizabeth Van Eycken, Kris Henau, Nadya Dimitrova, Mario Sekerija, Ladislav Dušek, Margit Mägi, Nea Malila, Maarit Leinonen, Michel Velten, Xavier Troussard, Veronique Bouvier, Anne-Valérie Guizard, Anne-Marie Bouvier, Patrick Arveux, Marc Maynadié, Anne-Sophie Woronoff, Michel Robaszkiewicz, Isabelle Baldi, Alain Monnereau, Brigitte Tretarre, Marc Colonna, Florence Molinié, Simona Bara, Claire Schvartz, Bénédicte Lapôtre-Ledoux, Pascale Grosclaude, Roland Stabenow, Sabine Luttmann, Alice Nennecke, Jutta Engel, Gabriele Schubert-Fritschle, Jan Heidrich, Bernd Holleczek, Jón Gunnlaugur Jónasson, Kerri Clough-Gorr, Harry Comber, Guido Mazzoleni, Adriano Giacomin, Antonella Sutera Sardo, Alessandro Barchielli, Diego Serraino, Roberta De Angelis, Sandra Mallone, Andrea Tavilla, Daniela Pierannunzio, Silvia Rossi, Mariano Santaquilani, Arnold Knijn, Fabio Pannozzo, Valerio Gennaro, Lucia Benfatto, Paolo Ricci, Mariangela Autelitano, Gianbattista Spagnoli, Mario Fusco, Mario Usala, Francesco Vitale, Maria Michiara, Rosario Tumino, Lucia Mangone, Fabio Falcini, Stefano Ferretti, Rosa Angela Filiberti, Enza Marani, Arturo Iannelli, Flavio Sensi, Silvano Piffer, Maria Gentilini, Anselmo Madeddu, Antonio Ziino, Sergio Maspero, Pina Candela, Fabrizio Stracci, Giovanna Tagliabue, Massimo Rugge, Annalisa Trama, Gemma Gatta, Laura Botta, Riccardo Capocaccia, Santa Pildava, Giedre Smailyte, Neville Calleja, Tom Børge Johannesen, Jadwiga Rachtan, Stanisław Góźdź, Jerzy Błaszczyk, Kamila Kępska, Gonçalo Forjaz de Lacerda, Maria José Bento, Ana Miranda, Chakameh Safaei Diba, Enrique Almar, Nerea Larrañaga, Arantza Lopez de Munain, Ana Torrella-Ramos, José María Díaz García, Rafael Marcos-Gragera, Maria Josè Sanchez, Carmen Navarro, Diego Salmeron, Conchi Moreno-Iribas, Jaume Galceran, Marià Carulla, Mohsen Mousavi, Christine Bouchardy, Silvia M. Ess, Andrea Bordoni, Isabelle Konzelmann, Jem Rashbass, Anna Gavin, David H. Brewster, Dyfed Wyn Huws, Otto Visser, Magdalena Bielska-Lasota, Maja Primic-Zakelj, Ian Kunkler, Ellen Benhamou, Lykoudis, P. M., Partelli, S., Muffatti, F., Caplin, M., Falconi, M., Fusai, G. K., Hackl, M., Van Eycken, E., Henau, K., Dimitrova, N., Sekerija, M., Dusek, L., Magi, M., Malila, N., Leinonen, M., Velten, M., Troussard, X., Bouvier, V., Guizard, A. -V., Bouvier, A. -M., Arveux, P., Maynadie, M., Woronoff, A. -S., Robaszkiewicz, M., Baldi, I., Monnereau, A., Tretarre, B., Colonna, M., Molinie, F., Bara, S., Schvartz, C., Lapotre-Ledoux, B., Grosclaude, P., Stabenow, R., Luttmann, S., Nennecke, A., Engel, J., Schubert-Fritschle, G., Heidrich, J., Holleczek, B., Jonasson, J. G., Clough-Gorr, K., Comber, H., Mazzoleni, G., Giacomin, A., Sardo, A. S., Barchielli, A., Serraino, D., De Angelis, R., Mallone, S., Tavilla, A., Pierannunzio, D., Rossi, S., Santaquilani, M., Knijn, A., Pannozzo, F., Gennaro, V., Benfatto, L., Ricci, P., Autelitano, M., Spagnoli, G., Fusco, M., Usala, M., Vitale, F., Michiara, M., Tumino, R., Mangone, L., Falcini, F., Ferretti, S., Filiberti, R. A., Marani, E., Iannelli, A., Sensi, F., Piffer, S., Gentilini, M., Madeddu, A., Ziino, A., Maspero, S., Candela, P., Stracci, F., Tagliabue, G., Rugge, M., Trama, A., Gatta, G., Botta, L., Capocaccia, R., Pildava, S., Smailyte, G., Calleja, N., Johannesen, T. B., Rachtan, J., Gozdz, S., Blaszczyk, J., Kepska, K., de Lacerda, G. F., Bento, M. J., Miranda, A., Diba, C. S., Almar, E., Larranaga, N., de Munain, A. L., Torrella-Ramos, A., Diaz Garcia, J. M., Marcos-Gragera, R., Sanchez, M. J., Navarro, C., Salmeron, D., Moreno-Iribas, C., Galceran, J., Carulla, M., Mousavi, M., Bouchardy, C., Ess, S. M., Bordoni, A., Konzelmann, I., Rashbass, J., Gavin, A., Brewster, D. H., Huws, D. W., Visser, O., Bielska-Lasota, M., Primic-Zakelj, M., Kunkler, I., Benhamou, E., Lykoudis P.M., Partelli S., Muffatti F., Caplin M., Falconi M., Fusai G.K., Hackl M., Van Eycken E., Henau K., Dimitrova N., Sekerija M., Dusek L., Magi M., Malila N., Leinonen M., Velten M., Troussard X., Bouvier V., Guizard A.-V., Bouvier A.-M., Arveux P., Maynadie M., Woronoff A.-S., Robaszkiewicz M., Baldi I., Monnereau A., Tretarre B., Colonna M., Molinie F., Bara S., Schvartz C., Lapotre-Ledoux B., Grosclaude P., Stabenow R., Luttmann S., Nennecke A., Engel J., Schubert-Fritschle G., Heidrich J., Holleczek B., Jonasson J.G., Clough-Gorr K., Comber H., Mazzoleni G., Giacomin A., Sardo A.S., Barchielli A., Serraino D., De Angelis R., Mallone S., Tavilla A., Pierannunzio D., Rossi S., Santaquilani M., Knijn A., Pannozzo F., Gennaro V., Benfatto L., Ricci P., Autelitano M., Spagnoli G., Fusco M., Usala M., Vitale F., Michiara M., Tumino R., Mangone L., Falcini F., Ferretti S., Filiberti R.A., Marani E., Iannelli A., Sensi F., Piffer S., Gentilini M., Madeddu A., Ziino A., Maspero S., Candela P., Stracci F., Tagliabue G., Rugge M., Trama A., Gatta G., Botta L., Capocaccia R., Pildava S., Smailyte G., Calleja N., Johannesen T.B., Rachtan J., Gozdz S., Blaszczyk J., Kepska K., de Lacerda G.F., Bento M.J., Miranda A., Diba C.S., Almar E., Larranaga N., de Munain A.L., Torrella-Ramos A., Diaz Garcia J.M., Marcos-Gragera R., Sanchez M.J., Navarro C., Salmeron D., Moreno-Iribas C., Galceran J., Carulla M., Mousavi M., Bouchardy C., Ess S.M., Bordoni A., Konzelmann I., Rashbass J., Gavin A., Brewster D.H., Huws D.W., Visser O., Bielska-Lasota M., Primic-Zakelj M., Kunkler I., and Benhamou E.

Subjects
Liver metastase, medicine.medical_specialty, Pathology, Socio-culturale, 03 medical and health sciences, Liver metastases, Rare Diseases, 0302 clinical medicine, Neuroendocrine tumours, Pancreas, Rare cancers, Multidisciplinary approach, Rare Disease, Neuroendocrine tumour, Humans, Medicine, Pancrea, Precision Medicine, Intensive care medicine, Liver metastases, Neuroendocrine tumours, Pancreas, Rare cancers, Patient Care Team, business.industry, Pancreatic Neoplasm, Rare cancer, General Medicine, Pancreatic Neoplasms, Survival Rate, Neuroendocrine Tumors, Surgery, Oncology, 030220 oncology & carcinogenesis, Mandate, 030211 gastroenterology & hepatology, business, Neuroendocrine Tumor, Delivery of Health Care, Human
Abstract

Pancreatic Neuroendocrine Neoplasms comprise a group of rare tumours with special biology, an often indolent behaviour and particular diagnostic and therapeutic requirements. The specialized biochemical tests and radiological investigations, the complexity of surgical options and the variety of medical treatments that require individual tailoring, mandate a multidisciplinary approach that can be optimally achieved through an organized network. The present study describes currents concepts in the management of these tumours as well as an insight into the challenges of delivering the pathway in and outside a Network.

Published
2019

19. Health and life insurance-related problems in very long-term cancer survivors in Germany: a population-based study

Author

Bernd Holleczek, Ron Pritzkuleit, Lena Koch-Gallenkamp, Volker Arndt, Daniela Doege, Melissa S Y Thong, Alice Nennecke, Linda Weißer, Andrea Eberle, Sylke Ruth Zeissig, Michael Schlander, Hermann Brenner, Annika Waldmann, Heike Bertram, APH - Aging & Later Life, and APH - Mental Health

Subjects
Male, Cancer Research, medicine.medical_specialty, Insurance problems, Cancer survivors, Population, Breast Neoplasms, Population-based, Logistic regression, Insurance Selection Bias, Financial toxicity, Odds, Statutory law, Life insurance, Germany, Surveys and Questionnaires, Medicine, Humans, education, Aged, education.field_of_study, Insurance, Health, Long-Term Cancer Survivors, business.industry, Cancer, Prostatic Neoplasms, General Medicine, Middle Aged, medicine.disease, Population based study, Insurance, Life, Oncology, Family medicine, Female, sense organs, business, Colorectal Neoplasms, Original Article – Cancer Research
Abstract

Purpose Limited research suggests that cancer survivors have problems with insurance. Our study aimed to gain insight into the proportion of very long-term (14–24 years post-diagnosis) survivors of breast, colorectal, and prostate cancers who had problems with health (HI) and life (LI) insurance. Methods We used data from CAESAR (CAncEr Survivorship—A multi-Regional population-based study). Participants completed questions on change in insurance providers since cancer diagnosis, problems with requesting (additional) HI or LI, and how potential problems were resolved. We conducted logistic regression to determine factors associated with change in statutory HI. Results Of the 2714 respondents, 174 (6%) reported having changed HI providers. Most switched between different statutory HI providers (86%), 9% from statutory to private, and 5% from private to statutory. Respondents who changed statutory HI providers were more likely to be prostate cancer survivors (OR 2.79, 95% CI 1.01–7.68) while being ≥ 65 years at time of diagnosis (OR 0.58, 95% CI 0.35–0.96) and having ≥ 2 comorbid conditions (OR 0.61, 95% CI 0.40–0.92) were associated with reduced odds for change. Problems in changing HI were minimal and were resolved with additional contribution. Of the 310 respondents who tried to get LI, 25 respondents reported having difficulties, of whom the majority had their request rejected. Conclusion Most cancer survivors did not change their HI nor tried to buy LI after cancer diagnosis. Problems with changing statutory HI were generally resolved with additional contribution while the main problem encountered when buying LI was rejection of request.

Published
2021

20. Health-Related Quality of Life in Very Long-Term Cancer Survivors 14–24 Years Post-Diagnosis Compared to Population Controls: A Population-Based Study

Author

Daniela Doege, Alice Nennecke, Lena Koch-Gallenkamp, Ron Pritzkuleit, Melissa S Y Thong, Heike Bertram, Sylke Ruth Zeissig, Volker Arndt, Andrea Eberle, Linda Weißer, Hermann Brenner, Lina Jansen, Annika Waldmann, Bernd Holleczek, APH - Aging & Later Life, and APH - Mental Health

Subjects
Cancer Research, Long-term effects, Health-related quality of life, Age effects, Population-based, Cancer survivorship, Population, cancer survivorship, health-related quality of life, population-based, long-term effects, age effects, Article, Metastasis, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Quality of life, Survivorship curve, medicine, Global health, 030212 general & internal medicine, education, RC254-282, Health related quality of life, education.field_of_study, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cancer, medicine.disease, humanities, Oncology, 030220 oncology & carcinogenesis, business, Demography
Abstract

Simple Summary Little is known about the health-related quality of life in very long-term cancer survivors 10 and more years post-diagnosis. Therefore, we compared the health-related quality of life of survivors of breast, colorectal, and prostate cancer (14–24 years post-diagnosis) with that of same-aged non-cancer controls, according to age, sex, and disease status (disease-free vs. stage IV, recurrence, metastasis, or second cancer). We found that the overall global health status/quality of life of cancer survivors more than a decade after diagnosis was slightly higher than that of population controls of the same age, but more symptoms and lower functioning were reported. Differences were small but statistically significant. Results differed by age, sex, and disease status. The findings point out the need for a comprehensive survivorship care program in order to monitor and treat potential late and long-term effects after the diagnosis and treatment of cancer. Survivorship care should be risk-adapted to survivors’ needs according to sociodemographic and clinical factors. Abstract (1) Background: Little is known about the health-related quality of life (HRQoL) in very long-term cancer survivors (VLTCS) 10 and more years post-diagnosis. The objective was to compare cancer survivors’ HRQoL 14–24 years post-diagnosis with that of same-aged non-cancer controls, stratified by age, sex, and disease status (disease-free vs. stage IV, recurrence, metastasis, or second cancer). (2) Methods: We recruited 2704 very long-term survivors of breast, colorectal and prostate cancer, and 1765 controls in German multi-regional population-based studies. The HRQoL was assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). Differences in the HRQoL were estimated with multiple regression, controlling for age, sex (where appropriate), and education. (3) Results: The overall global health status/quality of life of VLTCS more than a decade after diagnosis was slightly higher than that of population controls of the same age, but more symptoms and lower functioning were reported. Differences were small but statistically significant. Results differed by age, sex, and disease status. (4) Conclusions: The findings point out the need for a comprehensive survivorship care program in order to monitor and treat potential late and long-term effects after the diagnosis and treatment of cancer. Survivorship care should be risk-adapted to survivors’ needs according to sociodemographic and clinical factors.

Published
2021

21. Rare ovarian tumours: Epidemiology, treatment challenges in and outside a network setting

Author

Ray-Coquard, I., Annalisa, Trama, Seckl, Mj, Fotopoulou, C, Pautier, P, Pignata, S, Kristensen, G, Mangili, G, Falconer, H, Massuger, L, Sehouli, J, Pujade-Lauraine, E., Lorusso, D., Amant, F., Rokkones, E., Vergote, I., Ledermann, J. A., Rarecarenet, Wg, Monika, Hackl, Elizabeth, Van Eycken, Kris, Henau, Nadya, Dimitrova, Mario, Sekerija, Ladislav, Dušek, Margit, Mägi, Nea, Malila, Maarit, Leinonen, Michel, Velten, Xavier, Troussard, Veronique, Bouvier, Anne-Valérie, Guizard, Anne-Marie, Bouvier, Patrick, Arveux, Marc, Maynadié, Anne-Sophie, Woronoff, Michel, Robaszkiewicz, Isabelle, Baldi, Alain, Monnereau, Brigitte, Tretarre, Marc, Colonna, Florence, Molinié, Simona, Bara, Claire, Schvartz, Bénédicte, Lapôtre-doux, Pascale, Grosclaude, Roland, Stabenow, Sabine, Luttmann, Alice, Nennecke, Jutta, Engel, Gabriele, Schubert-Fritschle, Jan, Heidrich, Bernd, Holleczek, Jón, Gunnlaugur Jónasson, Kerri, Clough-Gorr, Harry, Comber, Guido, Mazzoleni, Adriano, Giacomin, Antonella, Sutera Sardo, Alessandro, Barchielli, Diego, Serraino, Roberta, De Angelis, Sandra, Mallone, Andrea, Tavilla, Daniela, Pierannunzio, Silvia, Rossi, Mariano, Santaquilani, Arnold, Knijn, Fabio, Pannozzo, Valerio, Gennaro, Lucia, Benfatto, Paolo, Ricci, Mariangela, Autelitano, Gianbattista, Spagnoli, Mario, Fusco, Mario, Usala, Francesco, Vitale, Maria, Michiara, Rosario, Tumino, Lucia, Mangone, Fabio, Falcini, Ferretti, Stefano, Rosa Angela, Filiberti, Enza, Marani, Arturo, Iannelli, Flavio, Sensi, Silvano, Piffer, Maria, Gentilini, Anselmo, Madeddu, Antonio, Ziino, Sergio, Maspero, Pina, Candela, Fabrizio, Stracci, Giovanna, Tagliabue, Massimo, Rugge, Gemma, Gatta, Laura, Botta, Riccardo, Capocaccia, Santa, Pildava, Giedre, Smailyte, Neville, Callejac, Tom, Børgejohannesen, Jadwiga, Rachtan, Stanisław, Góźdź, Jerzy, Błaszczyk, Kamila, Kępska, Gonçalo, Forjaz de Lacerda, Mariajosé, Bento, Ana, Miranda, Chakameh, Safaei Diba, Enrique, Almar, Nerea, Larrañaga, Arantza, Lopez de Munain, Ana, Torrella-Ramos, José María, Díaz García, Rafael, Marcos-Gragera, Mariajosè, Sanchez, Carmen, Navarro, Diego, Salmeron, Conchi, Moreno-Iribas, Jaume, Galceran, Marià, Carulla, Mohsen, Mousavi, Christine, Bouchardy, Silvia M., Ess, Andrea, Bordoni, Isabelle, Konzelmann, Jem, Rashbass, Anna, Gavin, David H., Brewster, Dyfed, Wyn Huws, Otto, Visser, Magdalena, Bielska-Lasota, Maja, Primic-Zakelj, Ian, Kunkler, Ellen, Benham, ARD - Amsterdam Reproduction and Development, CCA - Cancer Treatment and Quality of Life, Obstetrics and Gynaecology, Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Département d'Oncologie Médicale [Lyon] ( Centre Léon Bérard), and Centre Léon Bérard [Lyon]

Subjects
0301 basic medicine, medicine.medical_specialty, International Cooperation, [SDV]Life Sciences [q-bio], Gynecologic cancer, Rare cancer, Surgery, Oncology, MEDLINE, Socio-culturale, Gynecologic cancer, Rare cancer, law.invention, 03 medical and health sciences, 0302 clinical medicine, Rare Diseases, All institutes and research themes of the Radboud University Medical Center, Randomized controlled trial, law, Epidemiology, Surgery, Oncology, Prevalence, Medicine, Humans, Medical diagnosis, Intensive care medicine, Survival rate, ComputingMilieux_MISCELLANEOUS, Quality of Health Care, Ovarian Neoplasms, Clinical Trials as Topic, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], business.industry, Clinical study design, Incidence (epidemiology), Incidence, General Medicine, 3. Good health, Natural history, Europe, Survival Rate, 030104 developmental biology, 030220 oncology & carcinogenesis, Female, business, Delivery of Health Care
Abstract

Purpose of the review: More than 50% of all gynaecological cancers can be classified as rare tumours (defined as an annual incidence of

Published
2019

22. Health-Related Quality of Life in Very Long-Term Cancer Survivors 14–24 Years Post-Diagnosis Compared to Population Controls: A Population-Based Study

Author

Doege, Daniela, primary, Thong, Melissa S. Y., additional, Weißer, Linda, additional, Koch-Gallenkamp, Lena, additional, Jansen, Lina, additional, Bertram, Heike, additional, Eberle, Andrea, additional, Holleczek, Bernd, additional, Nennecke, Alice, additional, Pritzkuleit, Ron, additional, Waldmann, Annika, additional, Zeissig, Sylke Ruth, additional, Brenner, Hermann, additional, and Arndt, Volker, additional

Published
2021
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24. [Oral and pharyngeal cancer: incidence, mortality, and survival in Germany]

Author

Lina, Jansen, Julius, Moratin, Annika, Waldmann, Karim, Zaoui, Bernd, Holleczek, Alice, Nennecke, Ron, Pritzkuleit, Peter K, Plinkert, Jürgen, Hoffmann, and Volker, Arndt

Subjects
Male, Epidemiologie, Stage, Epidemiology, Incidence, Prognose, Pharyngeal Neoplasms, Mouth neoplasms, Prognosis, Mundhöhlentumore, Pharynxtumore, Germany, Leitthema, Humans, Female, Registries, Stadium
Abstract

Lip, oral cavity, and pharynx cancers (ICD-10: C00-C14) describe a heterogeneous group of tumors with strong variations in incidence, mortality, and survival by entity.This work provides a detailed overview of epidemiologic measures for these tumor entities, taking into account heterogeneity in age, sex, location, and stage.Incidence and mortality data for Germany for the years 1999-2016 were extracted from the interactive database of the Center for Cancer Registry Data (ZfKD). Age and stage distributions and five-year relative survival were calculated on the pooled ZfKD data set (diagnosis years 1999-2017).In 2016, overall incidence and mortality for all entities were 17.6 and 7.0 per 100,000 men and 6.5 and 1.8 per 100,000 women, respectively. The five-year relative survival in 2015-2017 was 53 and 63%, respectively. There were marked differences in survival as well as age and stage distributions between entities. Trend analyses showed an increase in age at diagnosis, particularly in male patients, and no change in stage distributions. However, five-year relative survival increased from 45% (men) and 59% (women) in 1999-2002 to 52% and 63% in 2013-2017.The marked heterogeneity of the studied tumors highlights the need to differentiate the analysis by sex and entity for meaningful interpretation of epidemiologic metrics. With the expansion of clinical cancer registration in Germany, additional analyses including other important clinical factors will be possible in the future.HINTERGRUND: Die Gruppe der Lippen‑, Mundhöhlen- und Pharynxkarzinome (ICD-10: C00–C14) beschreibt eine heterogene Gruppe bösartiger Tumoren, deren Inzidenz, Mortalität und Überleben sich nach Entität stark unterscheiden.Diese Arbeit gibt eine detaillierte Übersicht epidemiologischer Maßzahlen für diese Tumorentitäten unter Berücksichtigung der Heterogenität bezüglich Alter, Geschlecht, Lokalisation und Stadium.Inzidenz- und Mortalitätsdaten für Deutschland für die Jahre 1999–2016 wurden aus der interaktiven Datenbank des Zentrums für Krebsregisterdaten (ZfKD) extrahiert. Alters- und Stadienverteilungen und altersstandardisiertes relatives 5‑Jahres-Überleben wurden auf dem gepoolten ZfKD-Datensatz (Diagnosejahre 1999–2017) berechnet.Im Jahr 2016 lagen die Inzidenz und Mortalität für alle Entitäten insgesamt bei 17,6 bzw. 7,0 pro 100.000 Männern und 6,5 bzw. 1,8 pro 100.000 Frauen. Das relative 5‑Jahres-Überleben für 2015–2017 lag bei 53 % bzw. 63 %. Es zeigten sich deutliche Unterschiede in der Überlebensrate und in der Alters- und Stadienverteilung zwischen den Entitäten. Im zeitlichen Verlauf zeigte sich ein Anstieg des Alters bei Diagnose, insbesondere bei Männern, aber keine Veränderung in der Stadienverteilung. Trotzdem stieg das relative 5‑Jahres-Überleben zwischen 1999–2002 und 2013–2017 von 45 % (Männer) bzw. 59 % (Frauen) auf 52 % bzw. 63 %.Die starke Heterogenität der untersuchten Tumoren verdeutlicht die Notwendigkeit einer nach Geschlechtern und Lokalisationen getrennten Betrachtung für eine aussagekräftige Interpretation der epidemiologischen Kennzahlen. Mit Ausbau der klinischen Krebsregistrierung werden in Zukunft zusätzliche Analysen unter Einbezug weiterer wichtiger klinischer Faktoren möglich sein.

Published
2021

25. Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference

Author

Nicola Nicolai, Davide Biasoni, Mario A. Catanzaro, Maurizio Colecchia, Annalisa Trama, Monika Hackl, Elizabeth Van Eycken, Kris Henau, Nadya Dimitrova, Mario Sekerija, Ladislav Dušek, Margit Mägi, Nea Malila, Maarit Leinonen, Michel Velten, Xavier Troussard, Veronique Bouvier, Anne-Valérie Guizard, Anne-Marie Bouvier, Patrick Arveux, Marc Maynadié, Anne-Sophie Woronoff, Michel Robaszkiewic, Isabelle Baldi, Alain Monnereau, Brigitte Tretarre, Marc Colonna, Florence Molinié, Simona Bara, Claire Schvartz, Bénédicte Lapôtre-Ledoux, Pascale Grosclaude, Roland Stabenow, Sabine Luttmann, Alice Nennecke, Jutta Engel, Gabriele Schubert-Fritschle, Jan Heidrich, Bernd Holleczek, Jón Gunnlaugur Jónasson, Kerri Clough-Gorr, Harry Comber, Guido Mazzoleni, Adriano Giacomin, Antonella Sutera Sardo, Alessandr Barchielli, Diego Serraino, Roberta De Angelis, Sandra Mallone, Andrea Tavilla, Daniela Pierannunzio, Silvia Rossi, Mariano Santaquilani, Arnold Knijn, Fabio Pannozzo, Valerio Gennaro, Lucia Benfatto, Paolo Ricci, Mariangela Autelitano, Gianbattista Spagnoli, Mario Fusco, Mario Usala, Francesco Vitale, Maria Michiara, Rosario Tumino, Lucia Mangone, Fabio Falcini, Stefano Ferretti, Rosa Angela Filiberti, Enza Marani, Arturo Iannelli, Flavio Sensi, Silvano Piffer, Maria Gentilini, Anselmo Madeddu, Antonio Ziino, Sergio Maspero, Pina Candela, Fabrizio Stracci, Giovanna Tagliabue, Massimo Rugge, Gemma Gatta, Laura Botta, Riccardo Capocaccia, Santa Pildava, Giedre Smailyte, Neville Calleja, Tom Børge Johannesen, Jadwiga Rachtan, Stanisław Góźdź, Jerzy Błaszczyk, Kamila Kępska, Gonçalo Forjaz de Lacerda, Maria José Bento, Ana Miranda, Chakameh Safaei Diba, Enrique Almar, Nerea Larrañaga, Arantza Lopez de Munain, Ana Torrella-Ramos, José María Díaz García, Rafael Marcos-Gragera, Maria Josè Sanchez, Carmen Navarro, Diego Salmeron, Conchi Moreno-Iribas, Jaume Galceran, Marià Carulla, Mohsen Mousavi, Christine Bouchardy, Silvia M. Ess, Andrea Bordoni, Isabelle Konzelmann, Jem Rashbass, Anna Gavin, David H. Brewster, Dyfed Wyn Huws, Otto Visser, Magdalena Bielska-Lasota, Maja Primic-Zakelj, Ian Kunkler, Ellen Benhamou, Nicolai N., Biasoni D., Catanzaro M.A., Colecchia M., Trama A., Hackl M., Eycken E.V., Henau K., Dimitrova N., Sekerija M., Dusek L., Magi M., Malila N., Leinonen M., Velten M., Troussard X., Bouvier V., Guizard A.-V., Bouvier A.-M., Arveux P., Maynadie M., Woronoff A.-S., Robaszkiewic M., Baldi I., Monnereau A., Tretarre B., Colonna M., Molinie F., Bara S., Schvartz C., Lapotre-Ledoux B., Grosclaude P., Stabenow R., Luttmann S., Nennecke A., Engel J., Schubert-Fritschle G., Heidrich J., Holleczek B., Jonasson J.G., Clough-Gorr K., Comber H., Mazzoleni G., Giacomin A., Sutera Sardo A., Barchielli A., Serraino D., De Angelis R., Mallone S., Tavilla A., Pierannunzio D., Rossi S., Santaquilani M., Knijn A., Pannozzo F., Gennaro V., Benfatto L., Ricci P., Autelitano M., Spagnoli G., Fusco M., Usala M., Vitale F., Michiara M., Tumino R., Mangone L., Falcini F., Ferretti S., Filiberti R.A., Marani E., Iannelli A., Sensi F., Piffer S., Gentilini M., Madeddu A., Ziino A., Maspero S., Candela P., Stracci F., Tagliabue G., Rugge M., Gatta G., Botta L., Capocaccia R., Pildava S., Smailyte G., Calleja N., Johannesen T.B., Rachtan J., Gozdz S., Blaszczyk J., Kepska K., de Lacerda G.F., Bento M.J., Miranda A., Diba C.S., Almar E., Larranaga N., de Munain A.L., Torrella-Ramos A., Diaz Garcia J.M., Marcos-Gragera R., Sanchez M.J., Navarro C., Salmeron D., Moreno-Iribas C., Galceran J., Carulla M., Mousavi M., Bouchardy C., M. Ess S., Bordoni A., Konzelmann I., Rashbass J., Gavin A., Brewster D.H., Huws D.W., Visser O., Bielska-Lasota M., Primic-Zakelj M., Kunkler I., Benhamou E., Nicolai, N, Biasoni, D, Catanzaro, Ma, Colecchia, M, Trama, A, Hackl, M, Van Eycken, E, Henau, K, Dimitrova, N, Sekerija, M, Dusek, L, Maagi, M, Malila, N, Leinonen, M, Velten, M, Troussard, X, Bouvier, V, Guizard, Av, Bouvier, Am, Arveux, P, Maynadie, M, Woronoff, A, Robaszkiewicz, M, Baldi, I, Monnereau, A, Tretarre, B, Colonna, M, Molinie, F, Bara, S, Schvartz, C, Lapotre-Ledoux, B, Grosclaude, P, Stabenow, R, Luttmann, S, Nennecke, A, Engel, J, Schubert-Fritschle, G, Heidrich, J, Holleczek, B, Jonasson, Jg, Clough-Gorr, K, Comber, H, Mazzoleni, G, Giacomin, A, Sardo, A, Barchielli, A, Serraino, D, De Angelis, R, Mallone, S, Tavilla, A, Pierannunzio, D, Rossi, S, Santaquilani, M, Knijn, A, Pannozzo, F, Gennaro, V, Benfatto, L, Ricci, P, Autelitano, M, Spagnoli, G, Fusco, M, Usala, M, Vitale, F, Michiara, M, Tumino, R, Mangone, L, Falcini, F, Ferretti, S, Filiberti, Ra, Marani, E, Iannelli, A, Sensi, F, Puffer, S, Gentilini, M, Madeddu, A, Ziino, A, Maspero, S, Candela, P, Stracci, F, Tagliabue, G, Rugge, M, Gatta, G, Botta, L, Capocaccia, R, Pildava, S, Smailyte, G, Calleja, N, Johannesen, Tb, Rachtan, J, Gozdz, S, Blaszczyk, J, Kepska, K, de Lacerda, Gf, Bento, Mj, Miranda, A, Diba, C, Almar, E, Larranaga, N, de Munain, Al, Torrella-Ramos, M, Garcia, Jmd, Marcos-Gragera, R, Sanchez, Mj, Navarro, C, Salmeron, D, Moreno-Iribas, C, Galceran, J, Carulla, M, Mousavi, M, Bouchardy, C, Ess, Sm, Bordoni, A, Konzelmann, I, Rashbass, J, Gavin, A, Brewster, Dh, Huws, Dw, Visser, O, Bielska-Lasota, M, Primic-Zakelj, M, Kunkler, I, and Benhamou, E

Subjects
Oncology, Male, Survival, 030232 urology & nephrology, Disease, Carcinoma, Community network, Europe, Germ cell and embryonal, Neoplasms, Penis neoplasms, Rare diseases, Squamous cell, Tertiary care centres, Testicular neoplasms, Surgery, 0302 clinical medicine, Epidemiology, Testicular neoplasm, Referral and Consultation, General Medicine, Neoplasms, Germ Cell and Embryonal, Tertiary care centre, Survival Rate, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Carcinoma, Squamous Cell, Human, medicine.medical_specialty, Penile squamous cell carcinoma, Socio-culturale, Cancer Care Facilities, 03 medical and health sciences, Penis neoplasm, Rare Disease, Internal medicine, medicine, Humans, Penile Neoplasms, Neoplasm Staging, Penis Neoplasms, business.industry, Cancer Care Facilitie, Lymphatic Metastasi, medicine.disease, Testicular germ cell, Adult life, Penile Neoplasm, Proper treatment, Neoplasm, Lymph Node Excision, business, Delivery of Health Care
Abstract

Germ-cell tumours (GCT) of the testis and penile squamous cell carcinoma (PeSCC) are a rare and a very rare uro-genital cancers, respectively. Both tumours are well defined entities in terms of management, where specific recommendations - in the form of continuously up-to-dated guide lines- are provided. Impact of these tumour is relevant. Testicular GCT affects young, healthy men at the beginning of their adult life. PeSCC affects older men, but a proportion of these patients are young and the personal consequences of the disease may be devastating. Deviation from recommended management may be a reason of a significant prognostic worsening, as proper treatment favourably impacts on these tumours, dramatically on GCT and significantly on PeSCC. RARECAREnet data may permit to analyse how survivals may vary according to geographical areas, histology and age, leading to assume that non-homogeneous health-care resources may impact the cure and definitive outcomes. In support of this hypothesis, some epidemiologic datasets and clinical findings would indicate that survival may improve when appropriate treatments are delivered, linked to a different accessibility to the best health institutions, as a consequence of geographical, cultural and economic barriers. Finally, strong clues based on epidemiological and clinical data support the hypothesis that treatment delivered at reference centres or under the aegis of a qualified multi-institutional network is associated with a better prognosis of patients with these malignancies. The ERN EURACAN represents the best current European effort to answer this clinical need.

Published
2018

26. Sex differences in colorectal cancer survival: population-based analysis of 164,996 colorectal cancer patients in Germany.

Author

Ondrej Majek, Adam Gondos, Lina Jansen, Katharina Emrich, Bernd Holleczek, Alexander Katalinic, Alice Nennecke, Andrea Eberle, Hermann Brenner, and GEKID Cancer Survival Working Group

Subjects
Medicine, Science
Abstract

Risk of colorectal cancer (CRC) is considerably higher in men compared to women; however, there is inconclusive evidence of sex differences in CRC prognosis. We aimed to assess and explain sex differences in 5-year relative survival using standard and model-based period analysis among 164,996 patients diagnosed with CRC from 1997 to 2006 and reported to 11 German cancer registries covering a population of 33 million inhabitants. Age-adjusted 5-year relative survival was higher in women (64.5% vs. 61.9%, P

Published
2013
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27. Survival of malignant mesothelioma and other rare thoracic cancers in Germany and the United States: A population-based study

Author

Sirri, Eunice, Kieschke, Joachim, Vohmann, Claudia, Katalinic, Alexander, Nennecke, Alice, Ressing, Meike, Eberle, Andrea, Holleczek, Bernd, Jansen, Lina, Brenner, Hermann, and The GEKID Cancer Survival Working Group

Subjects
Oncology, Male, Cancer Research, 0302 clinical medicine, Risk Factors, Germany, Epidemiology, Mass Screening, Mesothelioma, Neoplasms, Glandular and Epithelial, Registries, Child, Relative survival, Incidence (epidemiology), Incidence, Age Factors, Middle Aged, Prognosis, 030220 oncology & carcinogenesis, Child, Preschool, Epidemiological Monitoring, Malignant Epithelial Tumors, Female, End results, Adult, medicine.medical_specialty, Adolescent, 03 medical and health sciences, Young Adult, Sex Factors, Internal medicine, medicine, Humans, United States, Survival, Rare thoracic cancers, Mortality, Aged, Health Services Needs and Demand, business.industry, Mesothelioma, Malignant, Infant, Newborn, Cancer, Infant, Thymus Neoplasms, medicine.disease, Survival Analysis, Population based study, Tracheal Neoplasms, business
Abstract

Evidence on survival of malignant mesothelioma (MM) and other rare thoracic cancers is limited due to the rarity of these cancer sites. Here, we provide a comprehensive overview of MM incidence and survival after MM and other rare thoracic cancers in Germany and the United States (US). Incidence was estimated from a German National Cancer Database and from the Surveillance, Epidemiology and End Results (SEER) 18 database for 2000–2014. Patients diagnosed in 1997–2013 with malignant epithelial tumors of the trachea (Etra), epithelial tumors of the thymus (Ethy) and MM were extracted from a German cancer survival database and from the SEER 13 database. Period analysis was employed to compute 5‐year relative survival (RS). During 2000–2014, an annual average of 0.9 and 0.6 MM cases per 100,000 person‐years was diagnosed in Germany and the US. Rates decreased in Germany and in the US. Patients with Ethy had highest 5‐year RS with US patients surviving longer (69.1% compared to 63.7%, p = 0.02). Survival after Etra was comparable in both countries (Germany 33.6%, US 34.4%, p = 0.07). Survival in MM patients was poor overall (Germany 11.8%, US 12.1%, p

Published
2019

28. Divergent Patterns and Trends in Breast Cancer Incidence, Mortality and Survival Among Older Women in Germany and the United States

Author

Jansen, Lina, primary, Holleczek, Bernd, additional, Kraywinkel, Klaus, additional, Weberpals, Janick, additional, Schröder, Chloé Charlotte, additional, Eberle, Andrea, additional, Emrich, Katharina, additional, Kajüter, Hiltraud, additional, Katalinic, Alexander, additional, Kieschke, Joachim, additional, Nennecke, Alice, additional, Sirri, Eunice, additional, Heil, Jörg, additional, Schneeweiss, Andreas, additional, and Brenner, Hermann, additional

Published
2020
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29. Global surveillance of trends in cancer survival 2000-14 (concord-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

Author

Claudia Allemani, Tomohiro Matsuda, Veronica Di Carlo, Rhea Harewood, Melissa Matz, Maja Nikšić, Audrey Bonaventure, Mikhail Valkov, Christopher J Johnson, Jacques Estève, Olufemi J Ogunbiyi, Gulnar Azevedo e Silva, Wan-Qing Chen, Sultan Eser, Gerda Engholm, Charles A Stiller, Alain Monnereau, Ryan R Woods, Otto Visser, Gek Hsiang Lim, Joanne Aitken, Hannah K Weir, Michel P Coleman, S Bouzbid, M Hamdi-Chérif, Z Zaidi, K Meguenni, D Regagba, S Bayo, T Cheick Bougadari, S S Manraj, A Fabowale, O J Ogunbiyi, D Bradshaw, N I M Somdyala, I Kumcher, F Moreno, G H Calabrano, S B Espinola, B Carballo Quintero, R Fita, M C Diumenjo, W D Laspada, S G Ibañez, C A Lima, P C F De Souza, K Del Pino, C Laporte, M P Curado, J C de Oliveira, C L A Veneziano, D B Veneziano, M R D O Latorre, L F Tanaka, M S Rebelo, M O Santos, G Azevedo e Silva, J C Galaz, M Aparicio Aravena, J Sanhueza Monsalve, D A Herrmann, S Vargas, V M Herrera, C J Uribe, L E Bravo, L S Garcia, N E Arias-Ortiz, D Morantes, D M Jurado, M C Yépez Chamorro, S Delgado, M Ramirez, Y H Galán Alvarez, P Torres, F Martínez-Reyes, L Jaramillo, R Quinto, J, M Mendoza, P Cueva, J G Yépez, B Bhakkan, J Deloumeaux, C Joachim, J Macni, R Carrillo, J Shalkow Klincovstein, R Rivera Gomez, E Poquioma, G Tortolero-Luna, D Zavala, R Alonso, E Barrios, A Eckstrand, C Nikiforuk, R R Woods, G Noonan, D Turner, E Kumar, B Zhang, F R McCrate, S Ryan, M MacIntyre, N Saint-Jacques, D E Nishri, C A McClure, K A Vriends, S Kozie, H Stuart-Panko, T Freeman, J T George, J T Brockhouse, D K O'Brien, A Holt, L Almon, S Kwong, C Morris, R Rycroft, L Mueller, C E Phillips, H Brown, B Cromartie, A G Schwartz, F Vigneau, G M Levin, B Wohler, R Bayakly, K C Ward, S L Gomez, M McKinley, R Cress, M D Green, K Miyagi, C J Johnson, L P Ruppert, C F Lynch, B Huang, T C Tucker, D Deapen, L Liu, M C Hsieh, X C Wu, M Schwenn, S T Gershman, R C Knowlton, G Alverson, G E Copeland, S Bushhouse, D B Rogers, J Jackson-Thompson, D Lemons, H J Zimmerman, M Hood, J Roberts-Johnson, J R Rees, B Riddle, K S Pawlish, A Stroup, C Key, C Wiggins, A R Kahn, M J Schymura, S Radhakrishnan, C Rao, L K Giljahn, R M Slocumb, R E Espinoza, F Khan, K G Aird, T Beran, J J Rubertone, S J Slack, L Garcia, D L Rousseau, T A Janes, S M Schwartz, S W Bolick, D M Hurley, M A Whiteside, P Miller-Gianturco, M A Williams, K Herget, C Sweeney, A T Johnson, M B Keitheri Cheteri, P Migliore Santiago, S E Blankenship, S Farley, R Borchers, R Malicki, J R Espinoza, J Grandpre, H K Weir, R Wilson, B K Edwards, A Mariotto. Y Lei, N Wang, J S Chen, Y Zhou, Y T He, G H Song, X P Gu, D Mei, H J Mu, H M Ge, T H Wu, Y Y Li, D L Zhao, F Jin, J H Zhang, F D Zhu, Q Junhua, Y L Yang, C X Jiang, W Biao, J Wang, Q L Li, H Yi, X Zhou, J Dong, W Li, F X Fu, S Z Liu, J G Chen, J Zhu, Y H Li, Y Q Lu, M Fan, S Q Huang, G P Guo, H Zhaolai, K Wei, W Q Chen, H Zeng, A V Demetriou, W K Mang, K C Ngan, A C Kataki, M Krishnatreya, P A Jayalekshmi, P Sebastian, A Nandakumar, R Malekzadeh, G Roshandel, L Keinan-Boker, B G Silverman, H Ito, H Nakagawa, M Sato, F Tobori, I Nakata, N Teramoto, M Hattori, Y Kaizaki, F Moki, H Sugiyama, M Utada, M Nishimura, K Yoshida, K Kurosawa, Y Nemoto, H Narimatsu, M Sakaguchi, S Kanemura, M Naito, R Narisawa, I Miyashiro, K Nakata, S Sato, M Yoshii, I Oki, N Fukushima, A Shibata, K Iwasa, C Ono, T Matsuda, O Nimri, K W Jung, Y J Won, E Alawadhi, A Elbasmi, A Ab Manan, F Adam, E Sanjaajmats, U Tudev, C Ochir, A M Al Khater, M M El Mistiri, G H Lim, Y Y Teo, C J Chiang, W C Lee, R Buasom, S Sangrajrang, S Kamsaard, S Wiangnon, K Daoprasert, D Pongnikorn, A Leklob, S Sangkitipaiboon, S L Geater, H Sriplung, O Ceylan, I Kög, O Dirican, T Köse, T Gurbuz, F E Karaşahin, D Turhan, U Aktaş, Y Halat, S Eser, C I Yakut, M Altinisik, Y Cavusoglu, A Türkköylü, N Üçüncü, M Hackl, A A Zborovskaya, O V Aleinikova, K Henau, L Van Eycken, Z Valerianova, M R Yordanova, M Šekerija, L Dušek, M Zvolský, G Engholm, H Storm, K Innos, M Mägi, N Malila, K Seppä, J Jégu, M Velten, E Cornet, X Troussard, A M Bouvier, A V Guizard, V Bouvier, G Launoy, P Arveux, M Maynadié, M Mounier, A S Worono, M Daoulas, M Robaszkiewicz, J Clavel, S Goujon, B Lacour, I Baldi, C Pouchieu, B Amadeo, G Coureau, A Monnereau, S Orazio, P M Preux, F Rharbaoui, E Marrer, B Trétarre, M Colonna, P Delafosse, K Ligier, S Plouvier, A Cowppli-Bony, F Molinié, S Bara, O Ganry, B Lapôtre- Ledoux, P Grosclaude, N Bossard, Z Uhry, F Bray, M Piñeros, J Estève, R Stabenow, H Wilsdorf-Köhler, A Eberle, S Luttmann, I Löhden, A L Nennecke, J Kieschke, E Sirri, K Emrich, S R Zeissig, B Holleczek, N Eisemann, A Katalinic, R A Asquez, V Kumar, E Petridou, E J Ólafsdóttir, L Tryggvadóttir, K Clough-Gorr, P M Walsh, H Sundseth, G Mazzoleni, F Vittadello, E Coviello, F Cuccaro, R Galasso, G Sampietro, A Giacomin, M Magoni, A Ardizzone, A D'Argenzio, M Castaing, G Grosso, A M Lavecchia, A Sutera Sardo, G Gola, L Gatti, P Ricci, S Ferretti, D Serraino, A Zucchetto, M V Celesia, R A Filiberti, F Pannozzo, A Melcarne, F Quarta, A G Russo, G Carrozzi, C Cirilli, L Cavalieri d'Oro, M Rognoni, M Fusco, M F Vitale, M Usala, R Cusimano, W Mazzucco, M Michiara, P Sgargi, L Boschetti, E Borciani, P Seghini, M M Maule, F Merletti, R Tumino, P Mancuso, M Vicentini, T Cassetti, R Sassatelli, F Falcini, S Giorgetti, A L Caiazzo, R Cavallo, R Cesaraccio, D R Pirino, M L Contrino, F Tisano, A C Fanetti, S Maspero, S Carone, A Mincuzzi, G Candela, T Scuderi, M A Gentilini, S Pier, S Rosso, A Barchielli, A Caldarella, F Bianconi, F Stracci, P Contiero, G Tagliabue, M Rugge, M Zorzi, S Beggiato, A Brustolin, F Berrino, G Gatta, M Sant, C Buzzoni, L Mangone, R Capocaccia, R De Angelis, R Zanetti, A Maurina, S Pildava, N Lipunova, I Vincerževskienė, D Agius, N Calleja, S Siesling, O Visser, Larønningen, B Møller, A Dyzmann-Sroka, M Trojanowski, S Góźdź, R Mężyk, T Mierzwa, L Molong, J Rachtan, S Szewczyk, J Błaszczyk, K Kępska, B Kościańska, K Tarocińska, M Zwierko, K Drosik, K M Maksimowicz, E Purwin-Porowska, E Reca, J Wójcik-Tomaszewska, A Tukiendorf, M Grądalska-Lampart, A U Radziszewska, A Gos, M Talerczyk, M Wyborska, J A Didkowska, U Wojciechowska, M Bielska-Lasota, G Forjaz de Lacerda, R A Rego, J Bastos, M A Silva, L Antunes, J Laranja Pontes, A Mayer-da-Silva, A Miranda, L M Blaga, D Coza, Russia: M Y Valkov, L Gusenkova, O Lazarevich, O Prudnikova, D M Vjushkov, A G Egorova, A E Orlov, L A Kudyakov, L V Pikalova, J Adamcik, C Safaei Diba, M Primic-Žakelj, V Zadnik, N Larrañaga, A Lopez de Munain, A A Herrera, R Redondas, R Marcos-Gragera, M L Vilardell Gil, E Molina, M J Sánchez Perez, P Franch Sureda, M Ramos Montserrat, M D Chirlaque, C Navarro, E E Ardanaz, M M Guevara, R Fernández-Delgado, R Peris-Bonet, M Carulla, J Galceran, C Alberich, M Vicente-Raneda, S Khan, D Pettersson, P Dickman, I Avelina, K Staehelin, B Camey, C Bouchardy, R Schaar, H Frick, C Herrmann, J L Bulliard, M Maspoli-Conconi, C E Kuehni, S M Redmond, A Bordoni, L Ortelli, A Chiolero, I Konzelmann, K L Matthes, S Rohrmann, Broggio, J Rashbass, D Fitzpatrick, A Gavin, D I Clark, A J Deas, D W Huws, C White, C Allemani, A Bonaventure, M P Coleman, V Di Carlo, R Harewood, M Matz, L Montel, M Nikšić, B Rachet, A D Turculeț, R Stephens, C A Stiller, E Chalker, H Phung, R Walton, H You, S Guthridge, F Johnson, J Aitken, P Gordon, K D'Onise, K Priest, B C Stokes, A Venn, H Farrugia, V Thurs eld, J Dowlin, D Currow, J Hendrix, C Lewis, Tıp Fakültesi, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Claudia Allemani, Tomohiro Matsuda, Veronica Di Carlo, Rhea Harewood, Melissa Matz, Maja Nikšić, Audrey Bonaventure, Mikhail Valkov, Christopher J Johnson, Jacques Estève, Olufemi J Ogunbiyi, Gulnar Azevedo e Silva, Wan-Qing Chen, Sultan Eser, Gerda Engholm, Charles A Stiller, Alain Monnereau, Ryan R Woods, Otto Visser, Gek Hsiang Lim, Joanne Aitken, Hannah K Weir, Michel P Coleman, S Bouzbid, M Hamdi-Chérif, Z Zaidi, K Meguenni, D Regagba, S Bayo, T Cheick Bougadari, S S Manraj, A Fabowale, O J Ogunbiyi, D Bradshaw, N I M Somdyala, I Kumcher, F Moreno, G H Calabrano, S B Espinola, B Carballo Quintero, R Fita, M C Diumenjo, W D Laspada, S G Ibañez, C A Lima, P C F De Souza, K Del Pino, C Laporte, M P Curado, J C de Oliveira, C L A Veneziano, D B Veneziano, M R D O Latorre, L F Tanaka, M S Rebelo, M O Santos, G Azevedo e Silva, J C Galaz, M Aparicio Aravena, J Sanhueza Monsalve, D A Herrmann, S Vargas, V M Herrera, C J Uribe, L E Bravo, L S Garcia, N E Arias-Ortiz, D Morantes, D M Jurado, M C Yépez Chamorro, S Delgado, M Ramirez, Y H Galán Alvarez, P Torres, F Martínez-Reyes, L Jaramillo, R Quinto, J, M Mendoza, P Cueva, J G Yépez, B Bhakkan, J Deloumeaux, C Joachim, J Macni, R Carrillo, J Shalkow Klincovstein, R Rivera Gomez, E Poquioma, G Tortolero-Luna, D Zavala, R Alonso, E Barrios, A Eckstrand, C Nikiforuk, R R Woods, G Noonan, D Turner, E Kumar, B Zhang, F R McCrate, S Ryan, M MacIntyre, N Saint-Jacques, D E Nishri, C A McClure, K A Vriends, S Kozie, H Stuart-Panko, T Freeman, J T George, J T Brockhouse, D K O'Brien, A Holt, L Almon, S Kwong, C Morris, R Rycroft, L Mueller, C E Phillips, H Brown, B Cromartie, A G Schwartz, F Vigneau, G M Levin, B Wohler, R Bayakly, K C Ward, S L Gomez, M McKinley, R Cress, M D Green, K Miyagi, C J Johnson, L P Ruppert, C F Lynch, B Huang, T C Tucker, D Deapen, L Liu, M C Hsieh, X C Wu, M Schwenn, S T Gershman, R C Knowlton, G Alverson, G E Copeland, S Bushhouse, D B Rogers, J Jackson-Thompson, D Lemons, H J Zimmerman, M Hood, J Roberts-Johnson, J R Rees, B Riddle, K S Pawlish, A Stroup, C Key, C Wiggins, A R Kahn, M J Schymura, S Radhakrishnan, C Rao, L K Giljahn, R M Slocumb, R E Espinoza, F Khan, K G Aird, T Beran, J J Rubertone, S J Slack, L Garcia, D L Rousseau, T A Janes, S M Schwartz, S W Bolick, D M Hurley, M A Whiteside, P Miller-Gianturco, M A Williams, K Herget, C Sweeney, A T Johnson, M B Keitheri Cheteri, P Migliore Santiago, S E Blankenship, S Farley, R Borchers, R Malicki, J R Espinoza, J Grandpre, H K Weir, R Wilson, B K Edwards, A Mariotto. Y Lei, N Wang, J S Chen, Y Zhou, Y T He, G H Song, X P Gu, D Mei, H J Mu, H M Ge, T H Wu, Y Y Li, D L Zhao, F Jin, J H Zhang, F D Zhu, Q Junhua, Y L Yang, C X Jiang, W Biao, J Wang, Q L Li, H Yi, X Zhou, J Dong, W Li, F X Fu, S Z Liu, J G Chen, J Zhu, Y H Li, Y Q Lu, M Fan, S Q Huang, G P Guo, H Zhaolai, K Wei, W Q Chen, H Zeng, A V Demetriou, W K Mang, K C Ngan, A C Kataki, M Krishnatreya, P A Jayalekshmi, P Sebastian, A Nandakumar, R Malekzadeh, G Roshandel, L Keinan-Boker, B G Silverman, H Ito, H Nakagawa, M Sato, F Tobori, I Nakata, N Teramoto, M Hattori, Y Kaizaki, F Moki, H Sugiyama, M Utada, M Nishimura, K Yoshida, K Kurosawa, Y Nemoto, H Narimatsu, M Sakaguchi, S Kanemura, M Naito, R Narisawa, I Miyashiro, K Nakata, S Sato, M Yoshii, I Oki, N Fukushima, A Shibata, K Iwasa, C Ono, T Matsuda, O Nimri, K W Jung, Y J Won, E Alawadhi, A Elbasmi, A Ab Manan, F Adam, E Sanjaajmats, U Tudev, C Ochir, A M Al Khater, M M El Mistiri, G H Lim, Y Y Teo, C J Chiang, W C Lee, R Buasom, S Sangrajrang, S Kamsaard, S Wiangnon, K Daoprasert, D Pongnikorn, A Leklob, S Sangkitipaiboon, S L Geater, H Sriplung, O Ceylan, I Kög, O Dirican, T Köse, T Gurbuz, F E Karaşahin, D Turhan, U Aktaş, Y Halat, S Eser, C I Yakut, M Altinisik, Y Cavusoglu, A Türkköylü, N Üçüncü, M Hackl, A A Zborovskaya, O V Aleinikova, K Henau, L Van Eycken, Z Valerianova, M R Yordanova, M Šekerija, L Dušek, M Zvolský, G Engholm, H Storm, K Innos, M Mägi, N Malila, K Seppä, J Jégu, M Velten, E Cornet, X Troussard, A M Bouvier, A V Guizard, V Bouvier, G Launoy, P Arveux, M Maynadié, M Mounier, A S Worono, M Daoulas, M Robaszkiewicz, J Clavel, S Goujon, B Lacour, I Baldi, C Pouchieu, B Amadeo, G Coureau, A Monnereau, S Orazio, P M Preux, F Rharbaoui, E Marrer, B Trétarre, M Colonna, P Delafosse, K Ligier, S Plouvier, A Cowppli-Bony, F Molinié, S Bara, O Ganry, B Lapôtre- Ledoux, P Grosclaude, N Bossard, Z Uhry, F Bray, M Piñeros, J Estève, R Stabenow, H Wilsdorf-Köhler, A Eberle, S Luttmann, I Löhden, A L Nennecke, J Kieschke, E Sirri, K Emrich, S R Zeissig, B Holleczek, N Eisemann, A Katalinic, R A Asquez, V Kumar, E Petridou, E J Ólafsdóttir, L Tryggvadóttir, K Clough-Gorr, P M Walsh, H Sundseth, G Mazzoleni, F Vittadello, E Coviello, F Cuccaro, R Galasso, G Sampietro, A Giacomin, M Magoni, A Ardizzone, A D'Argenzio, M Castaing, G Grosso, A M Lavecchia, A Sutera Sardo, G Gola, L Gatti, P Ricci, S Ferretti, D Serraino, A Zucchetto, M V Celesia, R A Filiberti, F Pannozzo, A Melcarne, F Quarta, A G Russo, G Carrozzi, C Cirilli, L Cavalieri d'Oro, M Rognoni, M Fusco, M F Vitale, M Usala, R Cusimano, W Mazzucco, M Michiara, P Sgargi, L Boschetti, E Borciani, P Seghini, M M Maule, F Merletti, R Tumino, P Mancuso, M Vicentini, T Cassetti, R Sassatelli, F Falcini, S Giorgetti, A L Caiazzo, R Cavallo, R Cesaraccio, D R Pirino, M L Contrino, F Tisano, A C Fanetti, S Maspero, S Carone, A Mincuzzi, G Candela, T Scuderi, M A Gentilini, S Pier, S Rosso, A Barchielli, A Caldarella, F Bianconi, F Stracci, P Contiero, G Tagliabue, M Rugge, M Zorzi, S Beggiato, A Brustolin, F Berrino, G Gatta, M Sant, C Buzzoni, L Mangone, R Capocaccia, R De Angelis, R Zanetti, A Maurina, S Pildava, N Lipunova, I Vincerževskienė, D Agius, N Calleja, S Siesling, O Visser, Larønningen, B Møller, A Dyzmann-Sroka, M Trojanowski, S Góźdź, R Mężyk, T Mierzwa, L Molong, J Rachtan, S Szewczyk, J Błaszczyk, K Kępska, B Kościańska, K Tarocińska, M Zwierko, K Drosik, K M Maksimowicz, E Purwin-Porowska, E Reca, J Wójcik-Tomaszewska, A Tukiendorf, M Grądalska-Lampart, A U Radziszewska, A Gos, M Talerczyk, M Wyborska, J A Didkowska, U Wojciechowska, M Bielska-Lasota, G Forjaz de Lacerda, R A Rego, J Bastos, M A Silva, L Antunes, J Laranja Pontes, A Mayer-da-Silva, A Miranda, L M Blaga, D Coza, Russia: M Y Valkov, L Gusenkova, O Lazarevich, O Prudnikova, D M Vjushkov, A G Egorova, A E Orlov, L A Kudyakov, L V Pikalova, J Adamcik, C Safaei Diba, M Primic-Žakelj, V Zadnik, N Larrañaga, A Lopez de Munain, A A Herrera, R Redondas, R Marcos-Gragera, M L Vilardell Gil, E Molina, M J Sánchez Perez, P Franch Sureda, M Ramos Montserrat, M D Chirlaque, C Navarro, E E Ardanaz, M M Guevara, R Fernández-Delgado, R Peris-Bonet, M Carulla, J Galceran, C Alberich, M Vicente-Raneda, S Khan, D Pettersson, P Dickman, I Avelina, K Staehelin, B Camey, C Bouchardy, R Schaar, H Frick, C Herrmann, J L Bulliard, M Maspoli-Conconi, C E Kuehni, S M Redmond, A Bordoni, L Ortelli, A Chiolero, I Konzelmann, K L Matthes, S Rohrmann, Broggio, J Rashbass, D Fitzpatrick, A Gavin, D I Clark, A J Deas, D W Huws, C White, C Allemani, A Bonaventure, M P Coleman, V Di Carlo, R Harewood, M Matz, L Montel, M Nikšić, B Rachet, A D Turculeț, R Stephens, C A Stiller, E Chalker, H Phung, R Walton, H You, S Guthridge, F Johnson, J Aitken, P Gordon, K D'Onise, K Priest, B C Stokes, A Venn, H Farrugia, V Thurs eld, J Dowlin, D Currow, J Hendrix, C Lewis

Subjects
0301 basic medicine, Universal Health Coverage, population-based registries, Relative Survival, Settore MED/42 - Igiene Generale E Applicata, Cancer -- Treatment, Humans, Neoplasms, Population Surveillance, Registries, Survival Rate, Medicine (all), 0302 clinical medicine, cancer survival, education.field_of_study, Relative survival, EPICENE, General Medicine, 3. Good health, trend, 030220 oncology & carcinogenesis, Public-Health, cancer surveillance, Liver cancer, survival, cancer registry, CONCORD-3, Cure, Childhood-Cancer, medicine.medical_specialty, population-based cancer registries, Womens Cancers, Population, Medicine (all),cancer survival, population-based cancer registries, Socio-culturale, United-States, Article, 03 medical and health sciences, Breast cancer, Cancer epidemiology, medicine, Nordic-Countries, Cancer -- Mortality, education, Survival rate, Cancer prevention, Alternative Approach, business.industry, Public health, Cancer, Cancer -- Patients -- Long-term care, medicine.disease, 030104 developmental biology, High-Income Countries, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Demography
Abstract

Eser, Sultan (Balikesir Author), Background In 2015, the second cycle of the CONCORD programme established global surveillance of cancer survival as a metric of the effectiveness of health systems and to inform global policy on cancer control. CONCORD-3 updates the worldwide surveillance of cancer survival to 2014. Methods CONCORD-3 includes individual records for 37.5 million patients diagnosed with cancer during the 15-year period 2000-14. Data were provided by 322 population-based cancer registries in 71 countries and territories, 47 of which provided data with 100% population coverage. The study includes 18 cancers or groups of cancers: oesophagus, stomach, colon, rectum, liver, pancreas, lung, breast (women), cervix, ovary, prostate, and melanoma of the skin in adults, and brain tumours, leukaemias, and lymphomas in both adults and children. Standardised quality control procedures were applied; errors were rectified by the registry concerned. We estimated 5-year net survival. Estimates were age-standardised with the International Cancer Survival Standard weights.Findings For most cancers, 5-year net survival remains among the highest in the world in the USA and Canada, in Australia and New Zealand, and in Finland, Iceland, Norway, and Sweden. For many cancers, Denmark is closing the survival gap with the other Nordic countries. Survival trends are generally increasing, even for some of the more lethal cancers: in some countries, survival has increased by up to 5% for cancers of the liver, pancreas, and lung. For women diagnosed during 2010-14, 5-year survival for breast cancer is now 89.5% in Australia and 90.2% in the USA, but international differences remain very wide, with levels as low as 66.1% in India. For gastrointestinal cancers, the highest levels of 5-year survival are seen in southeast Asia: in South Korea for cancers of the stomach (68.9%), colon (71.8%), and rectum (71.1%); in Japan for oesophageal cancer (36.0%); and in Taiwan for liver cancer (27.9%). By contrast, in the same world region, survival is generally lower than elsewhere for melanoma of the skin (59.9% in South Korea, 52.1% in Taiwan, and 49.6% in China), and for both lymphoid malignancies (52.5%, 50.5%, and 38.3%) and myeloid malignancies (45.9%, 33.4%, and 24.8%). For children diagnosed during 2010-14, 5-year survival for acute lymphoblastic leukaemia ranged from 49.8% in Ecuador to 95.2% in Finland. 5-year survival from brain tumours in children is higher than for adults but the global range is very wide (from 28.9% in Brazil to nearly 80% in Sweden and Denmark). Interpretation The CONCORD programme enables timely comparisons of the overall effectiveness of health systems in providing care for 18 cancers that collectively represent 75% of all cancers diagnosed worldwide every year. It contributes to the evidence base for global policy on cancer control. Since 2017, the Organisation for Economic Co-operation and Development has used findings from the CONCORD programme as the official benchmark of cancer survival, among their indicators of the quality of health care in 48 countries worldwide. Governments must recognise population-based cancer registries as key policy tools that can be used to evaluate both the impact of cancer prevention strategies and the effectiveness of health systems for all patients diagnosed with cancer., American Cancer Society Centers for Disease Control and Prevention Swiss Re Swiss Cancer Research foundation Swiss Cancer League Institut National du Cancer La Ligue Contre le Cancer Rossy Family Foundation US National Cancer Institute Susan G Komen Foundation

Published
2018

30. Data from Population-based Cancer Registration for Secondary Data Analysis: Methodological Challenges and Perspectives

Author

Hiltraud Kajüter, Klaus Kraywinkel, Alice Nennecke, Sylke Ruth Zeissig, Volker Arndt, Sabine Luttmann, Alexander Katalinic, and Bernd Holleczek

Subjects
Data Analysis, media_common.quotation_subject, Population, MEDLINE, secondary data, 03 medical and health sciences, 0302 clinical medicine, Germany, Neoplasms, medicine, data quality, Humans, Quality (business), cancer registration, 030212 general & internal medicine, ddc:610, Registries, education, media_common, education.field_of_study, Public Health, Environmental and Occupational Health, Academies and Institutes, Cancer, Secondary data, medicine.disease, 030210 environmental & occupational health, Data science, Cancer registry, Data quality, Epidemiology, Krebsregistrierung, Cancer registration, Datenqualität, Epidemiologie, Data sources, Sekundärdaten, Datenquellen, epidemiology, Business, 610 Medizin und Gesundheit, data sources, Record linkage
Abstract

Bevölkerungsbezogene Krebsregister haben eine entscheidende Rolle in der Krebsbekämpfung. Die wissenschaftliche Verwendung von Krebsregisterdaten ist allerdings nicht allein den Krebsregistern vorbehalten. Die Krebsregistrierung in Deutschland entwickelt sich aktuell von einer primär epidemiologischen Registrierung hin zu einer klinisch-epidemiologischen Registrierung mit Erfassung detaillierter klinischer Daten. Diese Entwicklung zusammen mit weiteren Optionen für die Verknüpfung von Datensätzen und einer künftigen langfristigen Nachbeobachtung bieten neue Möglichkeiten für die Versorgungs- und Gesundheitssystemforschung. Sowohl regionale bevölkerungsbezogene Krebsregister als auch das Zentrum für Krebsregisterdaten (ZfKD) am Robert Koch-Institut sowie internationale kollaborative Projekte und Dachorganisationen der Krebsregister können Wissenschaftlern Individualdaten oder aggregierte Daten für die Sekundärdatenanalyse bereitstellen. In dieser Übersichtsarbeit erläutern wir Zugangsmöglichkeiten zu Krebsregisterdaten, die Verfügbarkeit spezifischer Daten und Möglichkeiten der Verknüpfung der Registerdaten mit externen Datenquellen sowie mögliche Einschränkungen in Bezug auf Datenverfügbarkeit und Datenqualität wie auch typische Fehlerquellen bei Studiendesign und Datenanalyse. Population-based cancer registries have a long-standing role in cancer monitoring. Scientific use of cancer registry data is one important purpose of cancer registration, but use of cancer registry data is not restricted to cancer registries. Cancer registration in Germany is currently heading towards population-based collection of detailed clinical data. This development together with additional options for record linkage and long-term follow-up will offer new opportunities for health services and outcome research. Both regional population-based registries and the German Centre for Cancer Registry Data (ZfKD) at the Robert Koch-Institute as well as international cancer registries and consortia or organizations may provide external researchers access to individual or aggregate level data for secondary data analysis. In this review, we elaborate on the access to cancer registry data for research purposes, availability of specific data items, and options for data linkage with external data sources. We also discuss as well as on limitations in data availability and quality, and describe typical biases in design and analysis.

Published
2019

31. Reasons for low cervical cancer survival in new accession European Union countries: a EUROCARE-5 study

Author

Bielska-Lasota, M., Rossi, S., Krzyzak, M., Haelens, A., Domenic, A., De Angelis, R., Maciejczyk, A., Rodriguez-Barranco, M., Zadnik, V., Minicozzi, P., Hackl, M., Ihle, P., Vaneycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Cukelj, P., Dusek, L., Zvolsky, M., Magi, M., Aareleid, T., Malila, N., Seppa, K., Velten, M., Guizard, A. V., Faivre, J., Woronoff, A. S., Tretarre, B., Bossard, N., Uhry, Z., Colonna, M., Molinie, F., Cowppli-Bony, A., Bara, S., Lapotre-Ledoux, B., Grosclaude, P., Stabenow, R., Luttmann, S., Eberle, A., Brenner, H., Nennecke, A., Engel, J., Schubert-Fritschle, G., Heidrich, J., Holleczek, B., Katalinic, A., Birgisson, H., Tryggvadottir, L., Clough-Gorr, K., Mazzoleni, G., Bulatko, A., Buzzoni, C., Suterasardo, A., Mancuso, P., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Foschi, R., Margutti, C., Meneghini, E., Trama, A., Serraino, D., Dalmaso, L., Deangelis, R., Dibenedetto, C., Caldora, M., Francisci, S., Galati, F., Mallone, S., Pierannunzio, D., Tallon, M., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Filiberti, R. A., Marani, E., Ricci, P., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M. F., Usala, M., Vitale, F., Mazzucco, W., Michiara, M., Zanetti, R., Rosso, S., Tumino, R., Mangone, L., Difelice, E., Russo, A. G., Andreano, A., Falcini, F., Caiazzo, A. L., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Fanetti, A. C., Cometti, I., Candela, P., Scuderi, T., Stracci, F., Bianconi, F., Tagliabue, G., Contiero, P., Rugge, M., Zorzi, M., Pildava, S., Smailyte, G., Azzopardi, M., Calleja, N., Johannesen, T. B., Rachtan, J., Gozdz, S., Macek, P., Blaszczyk, J., Bebenek, M., Forjaz deLacerda, G., Bento, M. J., Antunes, L., Miranda, A., Mayer-da-Silva, A., Safaeidiba, C., Primic-Zakelj, M., Lopez deMunain, A., Gil, L., Diazgarcia, J. M., Marcos-Navarro, A. I., Marcos-Gragera, R., Puigdemont, M., Sanchez, M. J., Chang, D. Y. L., Chirlaque, M. D., Ardanaz, E., Guevara, M., Galceran, J., Carulla, M., Lambe, M., Khan, S., Staehelin, K., Bouchardy, C., Fournier, E., Mousavi, S. M., Ess, S. M., Lorez, M., Mousavi, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Aarts, M., Otter, R., Coleman, M., Allemani, C., Rachet, B., Rashbass, J., Broggio, J., Verne, J., Gavin, A., Donnelly, D., Morrison, D., Black, R., Huws, D. W., Thomas, R., Bielska‑Lasota, M, Rossi, S, Krzyżak, M, Haelens, A, Domenic, A, De Angelis, R, Maciejczyk, A, Rodríguez‑Barranco, M, Zadnik, V, Minicozzi, P, Vitale, F, and Mazzucco, W

Subjects
Morphology, Adult, Male, Stage at diagnosi, Survival, Adolescent, Socio-culturale, Uterine Cervical Neoplasms, Disease, Settore MED/42 - Igiene Generale E Applicata, 03 medical and health sciences, 0302 clinical medicine, Medicine, media_common.cataloged_instance, Humans, European Union, European union, Survival rate, Population-based study, media_common, Aged, Retrospective Studies, Cervical cancer, Aged, 80 and over, Cervical cancer, Europe, Morphology, Population-based study, Stage at diagnosis, Survival, 030219 obstetrics & reproductive medicine, Relative survival, business.industry, Absolute risk reduction, Obstetrics and Gynecology, Retrospective cohort study, Stage at diagnosis, General Medicine, Middle Aged, medicine.disease, Europe, Eastern european, Survival Rate, 030220 oncology & carcinogenesis, Female, business, Demography
Abstract

Purpose: With better access to early diagnosis and appropriate treatment, cervical cancer (CC) burden decreased in several European countries. In Eastern European (EE) countries, which accessed European Union in 2004, CC survival was worse than in the rest of Europe. The present study investigates CC survival differences across five European regions, considering stage at diagnosis (local, regional and metastatic), morphology (mainly squamous versus glandular tumours) and patients’ age. Methods: We analysed 101,714 CC women diagnosed in 2000–2007 and followed-up to December 2008. Age-standardised 5-year relative survival (RS) and the excess risks of cancer death in the 5years after diagnosis were computed. Results: EE women were older and less commonly diagnosed with glandular tumours. Proportions of local stage cancers were similar across Europe, while morphology- and stage-specific RS (especially for non-metastatic disease) were lower in Eastern Europe. Adjusting for age and morphology, excess risk of local stage CC death for EE patients remained higher than that for other European women. Conclusion: Stage, age and morphology alone do not explain worse survival in Eastern Europe: less effective care may play a role, probably partly due to fewer or inadequate resources being allocated to health care in this area, compared to the rest of Europe.

Published
2019

32. Treatment challenges in and outside a network setting: Head and neck cancers

Author

Ester Orlandi, Salvatore Alfieri, Christian Simon, Annalisa Trama, Lisa Licitra, Monika Hackl, Elizabeth Van Eycken, Kris Henau, Nadya Dimitrova, Mario Sekerija, Ladislav Dušek, Margit Mägi, Nea Malila, Maarit Leinonen, Michel Velten, Xavier Troussard, Veronique Bouvier, Anne-Valérie Guizard, Anne-Marie Bouvier, Patrick Arveux, Marc Maynadié, Anne-Sophie Woronoff, Michel Robaszkiewic, Isabelle Baldi, Alain Monnereau, Brigitte Tretarre, Marc Colonna, Florence Molinié, Simona Bara, Claire Schvartz, Bénédicte Lapôtre-Ledoux, Pascale Grosclaude, Roland Stabenow, Sabine Luttmann, Alice Nennecke, Jutta Engel, Gabriele Schubert-Fritschle, Jan Heidrich, Bernd Holleczek, Jón Gunnlaugur Jónasson, Kerri Clough-Gorr, Harry Comber, Guido Mazzoleni, Adriano Giacomin, Antonella Sutera Sardo, Alessandr Barchielli, Diego Serraino, Roberta De Angelis, Sandra Mallone, Andrea Tavilla, Daniela Pierannunzio, Silvia Rossi, Mariano Santaquilani, Arnold Knijn, Fabio Pannozzo, Valerio Gennaro, Lucia Benfatto, Paolo Ricci, Mariangela Autelitano, Gianbattista Spagnoli, Mario Fusco, Mario Usala, Francesco Vitale, Maria Michiara, Rosario Tumino, Lucia Mangone, Fabio Falcini, Stefano Ferretti, Rosa Angela Filiberti, Enza Marani, Arturo Iannelli, Flavio Sensi, Silvano Piffer, Maria Gentilini, Anselmo Madeddu, Antonio Ziino, Sergio Maspero, Pina Candela, Fabrizio Stracci, Giovanna Tagliabue, Massimo Rugge, Gemma Gatta, Laura Botta, Riccardo Capocaccia, Santa Pildava, Giedre Smailyte, Neville Calleja, Tom Børge Johannesen, Jadwiga Rachtan, Stanisław Góźdź, Jerzy Błaszczyk, Kamila Kępska, Gonçalo Forjaz de Lacerda, Maria José Bento, Ana Miranda, Chakameh Safaei Diba, Enrique Almar, Nerea Larrañaga, Arantza Lopez de Munain, Ana Torrella-Ramos, José María Díaz García, Rafael Marcos-Gragera, Maria Josè Sanchez, Carmen Navarro, Diego Salmeron, Conchi Moreno-Iribas, Jaume Galceran, Marià Carulla, Mohsen Mousavi, Christine Bouchardy, Silvia M. Ess, Andrea Bordoni, Isabelle Konzelmann, Jem Rashbass, Anna Gavin, David H. Brewster, Dyfed Wyn Huws, Otto Visser, Magdalena Bielska-Lasota, Maja Primic-Zakelj, Ian Kunkler, Ellen Benhamou, Orlandi E., Alfieri S., Simon C., Trama A., Licitra L., Hackl M., Eycken E.V., Henau K., Dimitrova N., Sekerija M., Dusek L., Magi M., Malila N., Leinonen M., Velten M., Troussard X., Bouvier V., Guizard A.-V., Bouvier A.-M., Arveux P., Maynadie M., Woronoff A.-S., Robaszkiewic M., Baldi I., Monnereau A., Tretarre B., Colonna M., Molinie F., Bara S., Schvartz C., Lapotre-Ledoux B., Grosclaude P., Stabenow R., Luttmann S., Nennecke A., Engel J., Schubert-Fritschle G., Heidrich J., Holleczek B., Jonasson J.G., Clough-Gorr K., Comber H., Mazzoleni G., Giacomin A., Sutera Sardo A., Barchielli A., Serraino D., De Angelis R., Mallone S., Tavilla A., Pierannunzio D., Rossi S., Santaquilani M., Knijn A., Pannozzo F., Gennaro V., Benfatto L., Ricci P., Autelitano M., Spagnoli G., Fusco M., Usala M., Vitale F., Michiara M., Tumino R., Mangone L., Falcini F., Ferretti S., Filiberti R.A., Marani E., Iannelli A., Sensi F., Piffer S., Gentilini M., Madeddu A., Ziino A., Maspero S., Candela P., Stracci F., Tagliabue G., Rugge M., Gatta G., Botta L., Capocaccia R., Pildava S., Smailyte G., Calleja N., Johannesen T.B., Rachtan J., Gozdz S., Blaszczyk J., Kepska K., de Lacerda G.F., Bento M.J., Miranda A., Diba C.S., Almar E., Larranaga N., de Munain A.L., Torrella-Ramos A., Diaz Garcia J.M., Marcos-Gragera R., Sanchez M.J., Navarro C., Salmeron D., Moreno-Iribas C., Galceran J., Carulla M., Mousavi M., Bouchardy C., Ess S.M., Bordoni A., Konzelmann I., Rashbass J., Gavin A., Brewster D.H., Huws D.W., Visser O., Bielska-Lasota M., Primic-Zakelj M., Kunkler I., and Benhamou E.

Subjects
0301 basic medicine, medicine.medical_specialty, Socio-culturale, Social issues, Multidisciplinary team, 03 medical and health sciences, Therapeutic approach, 0302 clinical medicine, Rare Diseases, Multidisciplinary approach, medicine, Humans, Adverse effect, Intensive care medicine, Head and neck cancer, Referral and Consultation, Patient Care Team, European reference networks joint action of rare cancers, Rare disease, business.industry, Head and Neck Neoplasm, General Medicine, medicine.disease, Europe, 030104 developmental biology, Clinical research, Oncology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, European reference networks joint action of rare cancer, Surgery, business, Delivery of Health Care, Human
Abstract

Head and neck cancer (HNC) is a rare disease that can affect different sites and is characterized by variable incidence and 5-year survival rates across Europe. Multiple factors need to be considered when choosing the most appropriate treatment for HNC patients, such as age, comorbidities, social issues, and especially whether to prefer surgery or radiation-based protocols. Given the complexity of this scenario, the creation of a highly specialized multidisciplinary team is recommended to guarantee the best oncological outcome and prevent or adequately treat any adverse effect. Data from literature suggest that the multidisciplinary team-based approach is beneficial for HNC patients and lead to improved survival rates. This result is likely due to improved diagnostic and staging accuracy, a more efficacious therapeutic approach and enhanced communication across disciplines. Despite the benefit of MTD, it must be noted that this approach requires considerable time, effort and financial resources and is usually more frequent in highly organized and high-volume centers. Literature data on clinical research suggest that patients treated in high-accrual centers report better treatment outcomes compared to patients treated in low-volume centers, where a lower radiotherapy-compliance and worst overall survival have been reported. There is general agreement that treatment of rare cancers such as HNC should be concentrated in high volume, specialized and multidisciplinary centers. In order to achieve this goal, the creation of international collaboration network is fundamental. The European Reference Networks for example aim to create an international virtual advisory board, whose objectives are the exchange of expertise, training, clinical collaboration and the reduction of disparities and enhancement of rationalize migration across Europe. The purpose of our work is to review all aspects and challenges in and outside this network setting planned for the management of HNC patients.

Published
2017

33. Erratum to 'The histology of ovarian cancer: Worldwide distribution and implications for international survival comparisons (CONCORD-2)' [Gynecol. Oncol. 144 (2017) 405-413]

Author

Matz, Melissa, Coleman, Michel P., Sant, Milena, Chirlaque, Maria Dolores, Visser, Otto, Gore, Martin, Allemani, Claudia, Bouzbid, S, Hamdi-chérif, M, Zaidi, Z, Bah, E, Swaminathan, R, Nortje, Sh, El Mistiri, Mm, Bayo, S, Malle, B, Manraj, Ss, Sewpaul-sungkur, R, Fabowale, A, Ogunbiyi, Oj, Bradshaw, D, Somdyala, Nim, Stefan, Dc, Abdel-rahman, M, Jaidane, L, Mokni, M, Kumcher, I, Moreno, F, González, Ms, Laura, Ea, Espinola, Sb, Calabrano, Gh, Carballo Quintero, B, Fita, R, Garcilazo, Da, Giacciani, Pl, Diumenjo, Mc, Laspada, Wd, Green, Ma, Lanza, Mf, Ibañez, Sg, Lima, Ca, Lobo De Oliveira, E, Daniel, C, Scandiuzzi, C, De Souza, Pcf, Melo, Cd, Del Pino, K, Laporte, C, Curado, Mp, De Oliveira, Jc, Veneziano, Cla, Veneziano, Db, Latorre, Mrdo, Tanaka, Lf, Azevedo E. Silva, G, Galaz, Jc, Moya, Ja, Herrmann, Da, Vargas, S, Herrera, Vm, Uribe, Cj, Bravo, Le, Arias-ortiz, Ne, Jurado, Dm, Yépez, Mc, Galán, Yh, Torres, P, Martínez-reyes, F, Pérez-meza, Ml, Jaramillo, L, Quinto, R, Cueva, P, Yépez, Jg, Torres-cintrón, Cr, Tortolero-luna, G, Alonso, R, Barrios, E, Nikiforuk, C, Shack, L, Coldman, Aj, Woods, Rr, Noonan, G, Turner, D, Kumar, E, Zhang, B, Mccrate, Fr, Ryan, S, Hannah, H, Dewar, Rad, Macintyre, M, Lalany, A, Ruta, M, Marrett, L, Nishri, De, Mcclure, C, Vriends, Ka, Bertrand, C, Louchini, R, Robb, K, Stuart-panko, H, Demers, S, Wright, S, George, Jt, Shen, X, Brockhouse, Jt, O'brien, Dk, Ward, Kc, Almon, L, Bates, J, Rycroft, R, Mueller, L, Phillips, C, Brown, H, Cromartie, B, Schwartz, Ag, Vigneau, F, Mackinnon, Ja, Wohler, B, Bayakly, Ar, Clarke, Ca, Glaser, Sl, West, D, Green, Md, Hernandez, By, Johnson, Cj, Jozwik, D, Charlton, Me, Lynch, Cf, Huang, B, Tucker, Tc, Deapen, D, Liu, L, Hsieh, Mc, Wu, Xc, Stern, K, Gershman, St, Knowlton, Rc, Alverson, J, Copeland, Ge, Rogers, Db, Lemons, D, Williamson, Ll, Hood, M, Hosain, Gm, Rees, Jr, Pawlish, Ks, Stroup, A, Key, C, Wiggins, C, Kahn, Ar, Schymura, Mj, Leung, G, Rao, C, Giljahn, L, Warther, B, Pate, A, Patil, M, Schubert, Ss, Rubertone, Jj, Slack, Sj, Fulton, Jp, Rousseau, Dl, Janes, Ta: Schwartz, Bolick, Sw, Hurley, Dm, Richards, J, Whiteside, Ma, Nogueira, Lm, Herget, K, Sweeney, C, Martin, J, Wang, S, Harrelson, Dg, Keitheri Cheteri, Mb, Farley, S, Hudson, Ag, Borchers, R, Stephenson, L, Espinoza, Jr, Weir, Hk, Edwards, Bk, Wang, N, Yang, L, Chen, Js, Song, Gh, Gu, Xp, Zhang, P, Ge, Hm, Zhao, Dl, Zhang, Jh, Zhu, Fd, Tang, Jg, Shen, Y, Wang, J, Li, Ql, Yang, Xp, Dong, J, Li, W, Cheng, Lp, Chen, Jg, Huang, Qh, Huang, Sq, Guo, Gp, Wei, K, Chen, Wq, Zeng, H, Demetriou, Av, Pavlou, P, Mang, Wk, Ngan, Kc, Kataki, Ac, Krishnatreya, M, Jayalekshmi, Pa, Sebastian, P, Sapkota, Sd, Verma, Y, Nandakumar, A, Suzanna, E, Keinan-boker, L, Silverman, Bg, Ito, H, Nakagawa, H, Hattori, M, Kaizaki, Y, Sugiyama, H, Utada, M, Katayama, K, Narimatsu, H, Kanemura, S, Koike, T, Miyashiro, I, Yoshii, M, Oki, I, Shibata, A, Matsuda, T, Nimri, O, Ab Manan, A, Bhoo-pathy, N, Tuvshingerel, S, Chimedsuren, O, Al Khater, Ahm, Al-eid, H, Jung, Kw, Won, Yj, Chiang, Cj, Lai, Ms, Suwanrungruang, K, Wiangnon, S, Daoprasert, K, Pongnikorn, D, Geater, Sl, Sriplung, H, Eser, S, Yakut, Ci, Hackl, M, Mühlböck, H, Oberaigner, W, Zborovskaya, Aa, Aleinikova, Ov, Henau, K, Van Eycken, L, Dimitrova, N, Valerianova, Z, Šekerija, M, Zvolský, M, Engholm, G, Storm, H, Innos, K, Mägi, M, Malila, N, Seppä, K, Jégu, J, Velten, M, Cornet, E, Troussard, X, Bouvier, Am, Faivre, J, Guizard, Av, Bouvier, V, Launoy, G, Arveux, P, Maynadié, M, Mounier, M, Fournier, E, Woronoff, As, Daoulas, M, Clavel, J, Le Guyader-peyrou, S, Monnereau, A, Trétarre, B, Colonna, M, Cowppli-bony, A, Molinié, F, Bara, S, Degré, D, Ganry, O, Lapôtre-ledoux, B, Grosclaude, P, Estève, J, Bray, F, Piñeros, M, Sassi, F, Stabenow, R, Eberle, A, Erb, C, Nennecke, A, Kieschke, J, Sirri, E, Kajueter, H, Emrich, K, Zeissig, Sr, Holleczek, B, Eisemann, N, Katalinic, A, Brenner, H, Asquez, Ra, Kumar, V, Ólafsdóttir, Ej, Tryggvadóttir, L, Comber, H, Walsh, Pm, Sundseth, H, Devigili, E, Mazzoleni, G, Giacomin, A, Bella, F, Castaing, M, Sutera, A, Gola, G, Ferretti, S, Serraino, D, Zucchetto, A, Lillini, R, Vercelli, M, Busco, S, Pannozzo, F, Vitarelli, S, Ricci, P, Pascucci, C, Autelitano, M, Cirilli, C, Federico, M, Fusco, M, Vitale, Mf, Usala, M, Cusimano, R, Mazzucco, W, Michiara, M, Sgargi, P, Maule, Mm, Sacerdote, C, Tumino, R, Di Felice, E, Vicentini, M, Falcini, F, Cremone, L, Budroni, M, Cesaraccio, R, Contrino, Ml, Tisano, F, Fanetti, Ac, Maspero, S, Candela, G, Scuderi, T, Gentilini, Ma, Piffer, S, Rosso, S, Sacchetto, L, Caldarella, A, La Rosa, F, Stracci, F, Contiero, P, Tagliabue, G, Dei Tos, Ap, Zorzi, M, Zanetti, R, Baili, P, Berrino, F, Gatta, G, Sant, M, Capocaccia, R, De Angelis, R, Liepina, E, Maurina, A, Smailyte, G, Agius, D, Calleja, N, Siesling, S, Visser, O, Larønningen, S, Møller, B, Dyzmann-sroka, A, Trojanowski, M, Góźdż, S, Mężyk, R, Grądalska-lampart, M, Radziszewska, Au, Didkowska, Ja, Wojciechowska, U, Błaszczyk, J, Kępska, K, Bielska-lasota, M, Kwiatkowska, K, Forjaz, G, Rego, Ra, Bastos, J, Silva, Ma, Antunes, L, Bento, Mj, Mayer-da-silva, A, Miranda, A, Coza, D, Todescu, Ai, Valkov, My, Adamcik, J, Safaei Diba, C, Primic-žakelj, M, Žagar, T, Stare, J, Almar, E, Mateos, A, Quirós, Jr, Bidaurrazaga, J, Larrañaga, N, Díaz García, Jm, Marcos, Ai, Marcos-gragera, R, Vilardell Gil, Ml, Molina, E, Sánchez, Mj, Franch Sureda, P, Ramos Montserrat, M, Chirlaque, Md, Navarro, C, Ardanaz, Ee, Moreno-iribas, Cc, Fernández-delgado, R, Peris-bonet, R, Galceran, J, Khan, S, Lambe, M, Camey, B, Bouchardy, C, Usel, M, Ess, Sm, Herrmann, C, Bulliard, Jl, Maspoli-conconi, M, Frick, H, Kuehni, Ce, Schindler, M, Bordoni, A, Spitale, A, Chiolero, A, Konzelmann, I, Dehler, Si, Matthes, Kl, Rashbass, J, Stiller, Ca, Fitzpatrick, D, Gavin, A, Bannon, F, Black, Rj, Brewster, Dh, Huws, Dw, White, C, Finan, P, Allemani, C, Bonaventure, A, Carreira, H, Coleman, Mp, Di Carlo, V, Harewood, R, Liu, K, Matz, M, Montel, L, Nikšić, M, Rachet, B, Sanz, N, Spika, D, Stephens, R, Peake, M, Chalker, E, Newman, L, Baker, D, Soeberg, Mj, Aitken, J, Scott, C, Stokes, Bc, Venn, A, Farrugia, H, Giles, Gg, Threlfall, T, Currow, D, You, H, Hendrix, J, Lewis, C., Matz, M., Coleman, M., Sant, M., Chirlaque, M., Visser, O., Gore, M., Allemani, C., Bouzbid, S., Hamdi-chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S., El Mistiri, M., Bayo, S., Malle, B., Manraj, S., Sewpaul-sungkur, R., Fabowale, A., Ogunbiyi, O., Bradshaw, D., Somdyala, N., Stefan, D., Abdel-rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M., Laura, E., Espinola, S., Calabrano, G., Carballo Quintero, B., Fita, R., Garcilazo, D., Giacciani, P., Diumenjo, M., Laspada, W., Green, M., Lanza, M., Ibañez, S., Lima, C., Lobo De Oliveira, E., Daniel, C., Scandiuzzi, C., De Souza, P., Melo, C., Del Pino, K., Laporte, C., Curado, M., De Oliveira, J., Veneziano, C., Veneziano, D., Latorre, M., Tanaka, L., Azevedo E. Silva, G., Galaz, J., Moya, J., Herrmann, D., Vargas, S., Herrera, V., Uribe, C., Bravo, L., Arias-ortiz, N., Jurado, D., Yépez, M., Galán, Y., Torres, P., Martínez-reyes, F., Pérez-meza, M., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J., Torres-cintrón, C., Tortolero-luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A., Woods, R., Noonan, G., Turner, D., Kumar, E., Zhang, B., Mccrate, F., Ryan, S., Hannah, H., Dewar, R., Macintyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D., Mcclure, C., Vriends, K., Bertrand, C., Louchini, R., Robb, K., Stuart-panko, H., Demers, S., Wright, S., George, J., Shen, X., Brockhouse, J., O'Brien, D., Ward, K., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A., Vigneau, F., Mackinnon, J., Wohler, B., Bayakly, A., Clarke, C., Glaser, S., West, D., Hernandez, B., Johnson, C., Jozwik, D., Charlton, M., Lynch, C., Huang, B., Tucker, T., Deapen, D., Liu, L., Hsieh, M., Xc, W., Stern, K., Gershman, S., Knowlton, R., Alverson, J., Copeland, G., Rogers, D., Lemons, D., Williamson, L., Hood, M., Hosain, G., Rees, J., Pawlish, K., Stroup, A., Key, C., Wiggins, C., Kahn, A., Schymura, M., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S., Rubertone, J., Slack, S., Fulton, J., Rousseau, D., Janes, Ta:, S., Sm, Bolick, S., Hurley, D., Richards, J., Whiteside, M., Nogueira, L., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D., Keitheri Cheteri, M., Farley, S., Hudson, A., Borchers, R., Stephenson, L., Espinoza, J., Weir, H., Edwards, B., Wang, N., Yang, L., Chen, J., Song, G., Xp, G., Zhang, P., Hm, G., Zhao, D., Zhang, J., Zhu, F., Tang, J., Shen, Y., Wang, J., Ql, L., Yang, X., Dong, J., Li, W., Cheng, L., Huang, Q., Huang, S., Guo, G., Wei, K., Chen, W., Zeng, H., Demetriou, A., Pavlou, P., Mang, W., Ngan, K., Kataki, A., Krishnatreya, M., Jayalekshmi, P., Sebastian, P., Sapkota, S., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-boker, L., Silverman, B., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Bhoo-pathy, N., Tuvshingerel, S., Chimedsuren, O., Al Khater, A., Al-eid, H., Jung, K., Won, Y., Chiang, C., Lai, M., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S., Sriplung, H., Eser, S., Yakut, C., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A., Aleinikova, O., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A., Faivre, J., Guizard, A., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A., Daoulas, M., Clavel, J., Le Guyader-peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R., Kumar, V., Ólafsdóttir, E., Tryggvadóttir, L., Comber, H., Walsh, P., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, E., Vitale, M., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M., Tisano, F., Fanetti, A., Maspero, S., Candela, G., Scuderi, T., Gentilini, M., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Larønningen, S., Møller, B., Dyzmann-sroka, A., Trojanowski, M., Góźdż, S., Mężyk, R., Grądalska-lampart, M., Radziszewska, A., Didkowska, J., Wojciechowska, U., Błaszczyk, J., Kępska, K., Bielska-lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R., Bastos, J., Silva, M., Antunes, L., Bento, M., Mayer-da-silva, A., Miranda, A., Coza, D., Todescu, A., Valkov, M., Adamcik, J., Safaei Diba, C., Primic-žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J., Bidaurrazaga, J., Larrañaga, N., Díaz García, J., Marcos, A., Marcos-gragera, R., Vilardell Gil, M., Molina, E., Sánchez, M., Franch Sureda, P., Ramos Montserrat, M., Navarro, C., Ardanaz, E., Moreno-iribas, C., Fernández-delgado, R., Peris-bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S., Herrmann, C., Bulliard, J., Maspoli-conconi, M., Frick, H., Kuehni, C., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S., Matthes, K., Rashbass, J., Stiller, C., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R., Brewster, D., Huws, D., White, C., Finan, P., Bonaventure, A., Carreira, H., Di Carlo, V., Harewood, R., Liu, K., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Chalker, E., Newman, L., Baker, D., Soeberg, M., Aitken, J., Scott, C., Stokes, B., Venn, A., Farrugia, H., Giles, G., Threlfall, T., Currow, D., You, H., Hendrix, J., and Lewis, C.

Subjects
Gynecology, medicine.medical_specialty, 030219 obstetrics & reproductive medicine, business.industry, Published Erratum, Obstetrics and Gynecology, Library science, Article, 03 medical and health sciences, 0302 clinical medicine, Oncology, Ovarian cancer, Editorial team, 030220 oncology & carcinogenesis, Medicine, epidemiology, business
Abstract

Objective. Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. Methods. The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995–2009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included.We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. Results. During 2005–2009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time. Conclusions. The distribution of ovarian cancer histology varieswidely worldwide. Type I epithelial, germcell and sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions.

Published
2017

34. Burden and centralised treatment in Europe of rare tumours: results of RARECAREnet—a population-based study

Author

Fabio Falcini, Charles A. Stiller, Diego Serraino, Antonella Sutera Sardo, Kerri Clough-Gorr, Mario Fusco, Véronique Bouvier, Silvia Francisci, Alain Monnereau, Carmen Navarro, Alessandro Barchielli, Annalisa Trama, Bénédicte Lapôtre-Ledoux, Stanislaw Gózdz, Isabelle Konzelmann, J. Błaszczyk, Laura Botta, Simona Bara, Flavio Sensi, Gonçalo Forjaz de Lacerda, Nadya Dimitrova, Lucia Mangone, Pamela Minicozzi, Maria Michiara, Neville Calleja, M Usala, E Marani, Innos Kaire, Tom Børge Johannesen, Ladislav Dušek, Sabine Luttmann, M Autelitano, Anne Sophie Woronoff, Vincent K Y Ho, Francesco Vitale, Silvano Piffer, Jan Maarten van der Zwan, Dyfed Wyn Huws, David H. Brewster, Margit Mägi, Zdravka Valerianova, Anna Luisa Caiazzo, Maja Primic Žakelj, Adriano Giacomin, E. Almar, F Bella, Ellen Benhamou, Arantza Lopez de Munain, Patrick Arveux, Claire Schvartz, José María Díaz García, M. Robaszkiewicz, Isabelle Baldi, Otto Visser, Mohsen Mousavi, Maria José Bento, Lesley A. Anderson, Chakameh Safaei Diba, Mariano Santaquilani, Gemma Gatta, Tina Žagar, Pina Candela, Jadwiga Rachtan, María José Sánchez, Andrea Bordoni, Monika Hackl, Gabriele Schubert-Fritschle, Nea Malila, Diego Salmerón, Massimo Rugge, Carmen Tereanu, Maarit K. Leinonen, Jem Rashbass, Arturo Iannelli, Milena Sant, Antonino Ziino Colanino, Marià Carulla, Christine Bouchardy, Keiu Paapsi, Marc Colonna, Jon G. Jonasson, Brigitte Trétarre, A.V. Guizard, Riccardo Capocaccia, Xavier Troussard, Jan Heidrich, Dominic Agius, Kamila Kepska, Daniela Pierannunzio, Santa Pildava, Stefano Ferretti, Silvia Rossi, Guido Mazzoleni, Rafael Marcos-Gragera, Giedre Smailyte, Gianbattista Spagnoli, Nancy Van Damme, Roland Stabenow, Anna Gavin, Paolo Baili, Anselmo Madeddu, Fabio Pannozzo, M. Sekerija, Silvia Ess, Sandra Mallone, Rosa Filiberti, Pascale Grosclaude, Florence Molinié, S Maspero, Alice Nennecke, Rosario Tumino, Renée Otter, Ana Torrella-Ramos, Fabrizio Stracci, Giovanna Tagliabue, Michel Velten, Andrea Tavilla, Marc Maynadié, Arnold Knijn, Conchi Moreno-Iribas, Eva Ardanaz, M.A. Gentilini, Paolo Ricci, Liesbet Van Eycken, Ana Miranda, Sabine Siesling, Nerea Larrañaga, Roberta De Angelis, Harry Comber, Paolo Collarile, K. Henau, Bernd Holleczek, Anne Marie Bouvier, Jutta Engel, Jaume Galceran, Gatta G., Capocaccia R., Botta L., Mallone S., De Angelis R., Ardanaz E., Comber H., Dimitrova N., Leinonen M.K., Siesling S., van der Zwan J.M., Van Eycken L., Visser O., Zakelj M.P., Anderson L.A., Bella F., Kaire I., Otter R., Stiller C.A., Trama A., Hackl M., Henau K., Van Damme N., Valerianova Z., Sekerija M., Dusek L., Magi M., Paapsi K., Malila N., Velten M., Troussard X., Bouvier V., Guizard A.-V., Bouvier A.-M., Arveux P., Maynadie M., Woronoff A.-S., Robaszkiewicz M., Baldi I., Monnereau A., Tretarre B., Colonna M., Molinie F., Bara S., Schvartz C., Lapotre-Ledoux B., Grosclaude P., Stabenow R., Luttmann S., Nennecke A., Engel J., SchubertFritschle G., Heidrich J., Holleczek B., Jonasson J.G., Clough-Gorr K., Mazzoleni G., Giacomin A., Sardo A.S., Barchielli A., Serraino D., Collarile P., Pannozzo F., Ricci P., Autelitano M., Spagnoli G., Fusco M., Usala M., Vitale F., Michiara M., Tumino R., Mangone L., Falcini F., Ferretti S., Filiberti R.A., Marani E., Caiazzo A.L., Iannelli A., Sensi F., Piffer S., Gentilini M., Madeddu A., Colanino A.Z., Maspero S., Candela P., Stracci F., Tagliabue G., Rugge M., Baili P., Minicozzi P., Sant M., Tereanu C., Francisci S., Tavilla A., Pierannunzio D., Rossi S., Santaquilani M., Knijn A., Pildava S., Smailyte G., Calleja N., Agius D., Johannesen T.B., Rachtan J., Gozdz S., Blaszczyk J., Kepska K., Lacerda G.F.D., Bento M.J., Miranda A., Diba C.S., Zagar T., Almar E., Larranaga N., Munain A.L.D., Torrella-Ramos A., Garcia J.M.D., Marcos-Gragera R., Sanchez M.J., Navarro C., Salmeron D., Moreno-Iribas C., Galceran J., Carulla M., Mousavi M., Bouchardy C., Ess S.M., Bordoni A., Konzelmann I., Rashbass J., Gavin A., Brewster D.H., Huws D.W., Ho V.K., and Benhamou E.

Subjects
Male, 0301 basic medicine, Pathology, population-based registries, Cancer Care Facilities, Delivery of Health Care, Europe, Female, Hospitalization, Humans, Incidence, Neoplasms, Rare Diseases, Registries, Survival Rate, Oncology, 0302 clinical medicine, Medicine, media_common, Tumors -- Treatment -- Europe, education.field_of_study, Relative survival, Incidence (epidemiology), RARECARE project, 030220 oncology & carcinogenesis, medicine.medical_specialty, Health surveys, Population, Socio-culturale, 03 medical and health sciences, SDG 3 - Good Health and Well-being, media_common.cataloged_instance, Cancer -- Mortality, Risk factor, European union, education, Survival rate, Oncology, cancer burden, incidence, rare cancer,population-based registries, rare cancers, cancer registry, RARECARE, business.industry, Rare cancer, Cancer -- Patients -- Long-term care, Cancer registry, 030104 developmental biology, cancer burden, business, Demography, Rare disease
Abstract

Background: Rare cancers pose challenges for diagnosis, treatments, and clinical decision making. Information about rare cancers is scant. The RARECARE project defined rare cancers as those with an annual incidence of less than six per 100 000 people in European Union (EU). We updated the estimates of the burden of rare cancers in Europe, their time trends in incidence and survival, and provide information about centralisation of treatments in seven European countries. Methods: We analysed data from 94 cancer registries for more than 2 million rare cancer diagnoses, to estimate European incidence and survival in 2000–07 and the corresponding time trends during 1995–2007. Incidence was calculated as the number of new cases divided by the corresponding total person-years in the population. 5-year relative survival was calculated by the Ederer-2 method. Seven registries (Belgium, Bulgaria, Finland, Ireland, the Netherlands, Slovenia, and the Navarra region in Spain) provided additional data for hospitals treating about 220 000 cases diagnosed in 2000–07. We also calculated hospital volume admission as the number of treatments provided by each hospital rare cancer group sharing the same referral pattern. Findings: Rare cancers accounted for 24% of all cancers diagnosed in the EU during 2000–07. The overall incidence rose annually by 0.5% (99·8% CI 0·3–0·8). 5-year relative survival for all rare cancers was 48·5% (95% CI 48·4 to 48·6), compared with 63·4% (95% CI 63·3 to 63·4) for all common cancers. 5-year relative survival increased (overall 2·9%, 95% CI 2·7 to 3·2), from 1999–2001 to 2007–09, and for most rare cancers, with the largest increases for haematological tumours and sarcomas. The amount of centralisation of rare cancer treatment varied widely between cancers and between countries. The Netherlands and Slovenia had the highest treatment volumes. Interpretation: Our study benefits from the largest pool of population-based registries to estimate incidence and survival of about 200 rare cancers. Incidence trends can be explained by changes in known risk factors, improved diagnosis, and registration problems. Survival could be improved by early diagnosis, new treatments, and improved case management. The centralisation of treatment could be improved in the seven European countries we studied., peer-reviewed

Published
2017

35. Survival of 86,690 patients with thyroid cancer: A population-based study in 29 European countries from EUROCARE-5

Author

L. Dal Maso, A. Tavilla, F. Pacini, D. Serraino, B.A.C. van Dijk, M.D. Chirlaque, R. Capocaccia, N. Larrañaga, M. Colonna, D. Agius, E. Ardanaz, J. Rubió-Casadevall, A. Kowalska, S. Virdone, S. Mallone, H. Amash, R. De Angelis, M. Hackl, N. Zielonke, E. Van Eycken, K. Henau, Z. Valerianova, N. Dimitrova, M. Sekerija, L. Dušek, M. Zvolský, H. Storm, G. Engholm, M. Mägi, T. Aareleid, N. Malila, K. Seppä, M. Velten, A.V. Guizard, J. Faivre, A.S. Woronoff, B. Tretarre, N. Bossard, Z. Uhry, F. Molinié, S. Bara, C. Schvartz, B. Lapôtre-Ledoux, P. Grosclaude, R. Stabenow, S. Luttmann, A. Eberle, H. Brenner, A. Nennecke, J. Engel, G. Schubert-Fritschle, J. Heidrich, B. Holleczek, A. Katalinic, J.G. Jónasson, L. Tryggvadóttir, H. Comber, G. Mazzoleni, A. Bulatko, C. Buzzoni, A. Giacomin, A. Sutera Sardo, A. Mazzei, S. Ferretti, A. Barchielli, A. Caldarella, G. Gatta, M. Sant, C. Amati, P. Baili, F. Berrino, S. Bonfarnuzzo, L. Botta, F. Di Salvo, R. Foschi, C. Margutti, E. Meneghini, P. Minicozzi, A. Trama, A. Zucchetto, M. Caldora, E. Carrani, S. Francisci, D. Pierannunzio, P. Roazzi, S. Rossi, M. Santaquilani, F. Pannozzo, S. Busco, R.A. Filiberti, M. Vercelli, P. Ricci, M. Autelitano, G. Spagnoli, C. Cirilli, M. Fusco, M.F. Vitale, M. Usala, F. Vitale, B. Ravazzolo, M. Michiara, R. Tumino, L. Mangone, M. Vicentini, F. Falcini, A. Iannelli, O. Sechi, R. Cesaraccio, S. Piffer, A. Madeddu, F. Tisano, S. Maspero, A.C. Fanetti, R. Zanetti, S. Rosso, P. Candela, T. Scuderi, F. Stracci, A. Rocca, G. Tagliabue, P. Contiero, M. Rugge, S. Tognazzo, S. Pildava, G. Smailyte, N. Calleja, T.B. Johannesen, J. Rachtan, S. Góźdź, R. Mężyk, J. Błaszczyk, M. Bębenek, M. Bielska-Lasota, G. Forjaz de Lacerda, M.J. Bento, C. Castro, A. Miranda, A. Mayer-da-Silva, C. Safaei Diba, M. Primic-Zakelj, M. Errezola, J. Bidaurrazaga, J.M. Díaz García, A.I. Marcos-Navarro, R. Marcos-Gragera, A. Izquierdo Font, M.J. Sanchez, E. Molina, C. Navarro, C. Moreno-Iribas, J. Galceran, M. Carulla, M. Lambe, S. Khan, M. Mousavi, C. Bouchardy, M. Usel, S.M. Ess, H. Frick, M. Lorez, C. Herrmann, A. Bordoni, A. Spitale, I. Konzelmann, O. Visser, V. Ho, R. Otter, M. Coleman, C. Allemani, B. Rachet, J. Rashbass, J. Broggio, J. Verne, A. Gavin, C. Donnelly, D.H. Brewster, D.W. Huws, C. White, Registre des cancers du Tarn, France, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Registre général des cancers du Tarn, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Dal Maso L., Tavilla A., Pacini F., Serraino D., van Dijk B.A.C., Chirlaque M.D., Capocaccia R., Larranaga N., Colonna M., Agius D., Ardanaz E., Rubio-Casadevall J., Kowalska A., Virdone S., Mallone S., Amash H., De Angelis R., Hackl M., Zielonke N., Van Eycken E., Henau K., Valerianova Z., Dimitrova N., Sekerija M., Dusek L., Zvolsky M., Storm H., Engholm G., Magi M., Aareleid T., Malila N., Seppa K., Velten M., Guizard A.V., Faivre J., Woronoff A.S., Tretarre B., Bossard N., Uhry Z., Molinie F., Bara S., Schvartz C., Lapotre-Ledoux B., Grosclaude P., Stabenow R., Luttmann S., Eberle A., Brenner H., Nennecke A., Engel J., Schubert-Fritschle G., Heidrich J., Holleczek B., Katalinic A., Jonasson J.G., Tryggvadottir L., Comber H., Mazzoleni G., Bulatko A., Buzzoni C., Giacomin A., Sutera Sardo A., Ferretti S., Mazzei A., Caldarella A., Gatta G., Sant M., Amati C., Baili P., Berrino F., Bonfarnuzzo S., Botta L., Di Salvo F., Foschi R., Margutti C., Meneghini E., Minicozzi P., Trama A., Zucchetto A., Caldora M., Carrani E., Francisci S., Pierannunzio D., Roazzi P., Rossi S., Santaquilani M., Pannozzo F., Busco S., Filiberti R.A., Vercelli M., Ricci P., Autelitano M., Spagnoli G., Cirilli C., Fusco M., Vitale M.F., Usala M., Vitale F., Ravazzolo B., Michiara M., Tumino R., Mangone L., Vicentini M., Falcini F., Iannelli A., Sechi O., Cesaraccio R., Piffer S., Madeddu A., Tisano F., Maspero S., Fanetti A.C., Zanetti R., Rosso S., Candela P., Scuderi T., Stracci F., Rocca A., Tagliabue G., Contiero P., Rugge M., Tognazzo S., Pildava S., Smailyte G., Calleja N., Johannesen T.B., Rachtan J., Gozdz S., Mezyk R., Blaszczyk J., Bebenek M., Bielska-Lasota M., Forjaz de Lacerda G., Bento M.J., Castro C., Miranda A., Mayer-da-Silva A., Safaei Diba C., Primic-Zakelj M., Errezola M., Bidaurrazaga J., Diaz Garcia J.M., Marcos-Navarro A.I., Marcos-Gragera R., Izquierdo Font A., Sanchez M.J., Molina E., Navarro C., Moreno-Iribas C., Galceran J., Carulla M., Lambe M., Khan S., Mousavi M., Bouchardy C., Usel M., Ess S.M., Frick H., Lorez M., Herrmann C., Bordoni A., Spitale A., Konzelmann I., Visser O., Ho V., Otter R., Coleman M., Allemani C., Rachet B., Rashbass J., Broggio J., Verne J., Gavin A., Donnelly C., Brewster D.H., Huws D.W., and White C.

Subjects
Registrie, Male, Cancer Research, IMPACT, Cancer registrie, [SDV]Life Sciences [q-bio], Papillary, 0302 clinical medicine, QUALITY-OF-LIFE, Residence Characteristics, Adenocarcinoma, Follicular, Cancer registries, Registries, Thyroid cancer, Thyroid Neoplasm, education.field_of_study, Relative survival, Incidence (epidemiology), Mortality rate, Incidence, Diagnosis-Related Group, EUROCARE, Europe, Adolescent, Adult, Aged, Carcinoma, Carcinoma, Papillary, Diagnosis-Related Groups, Female, Humans, Middle Aged, Sex Distribution, Thyroid Neoplasms, Young Adult, Oncology, PREVALENCE, 3. Good health, Thyroid Cancer, Papillary, 030220 oncology & carcinogenesis, Cohort, Human, medicine.medical_specialty, Population, GEOGRAPHICAL-DISTRIBUTION, UNITED-STATES, Socio-culturale, 030209 endocrinology & metabolism, Adenocarcinoma, RECENT TRENDS, 03 medical and health sciences, MANAGEMENT, medicine, education, Survival rate, business.industry, MORTALITY, Follicular, medicine.disease, Cancer registry, Surgery, MICROCARCINOMA, Residence Characteristic, business, Demography
Abstract

Background: Incidence rates of thyroid cancer (TC) increased in several countries during the last 30 years, while mortality rates remained unchanged, raising important questions for treatment and follow-up of TC patients. This study updates population-based estimates of relative survival (RS) after TC diagnosis in Europe by sex, country, age, period and histology.Methods: Data from 87 cancer registries in 29 countries were extracted from the EUROCARE-5 dataset. One-and 5-year RS were estimated using the cohort approach for 86,690 adult TC patients diagnosed in 2000-2007 and followed-up to 12/31/2008. RS trends in 1999-2007 and 10-year RS in 2005-2007 were estimated using the period approach.Results: In Europe 2000-2007, 5-year RS after TC was 88% in women and 81% in men. Survival rates varied by country and were strongly correlated (Pearson rho = 75%) with country-specific incidence rates. Five-year RS decreased with age (in women from > 95% at age 15-54 to 57% at age 75+), from 98% in women and 94% in men with papillary TC to 14% in women and 12% in men with anaplastic TC. Proportion of papillary TC varied by country and increased over time, while survival rates were similar across areas and periods. In 1999-2007, 5-year RS increased by five percentage points for all TCs but only by two for papillary and by four for follicular TC. Ten-year RS in 2005-2007 was 89% in women and 79% in men.Conclusions: The reported increasing TC survival trend and differences by area are mainly explained by the varying histological case-mix of cases. (C) 2017 Elsevier Ltd. All rights reserved.

Published
2017

36. Rezidive in der neuen flächendeckenden klinischen Krebsregistrierung am Beispiel gynäkologischer Tumoren in Hamburg

Author

Nennecke, Alice, Erb, Cynthia, Löhden, Imma, and Waldmann, Annika

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Rezidive von bösartigen Neubildungen sind für die betroffenen Patientinnen und Patienten ebenso wie für die onkologische Versorgung sehr relevant. Letzteres gilt insbesondere im Hinblick auf die demografisch bedingte Zunahme von Krebserkrankungen und die steigende Anzahl [zum vollständigen Text gelangen Sie über die oben angegebene URL], 17. Deutscher Kongress für Versorgungsforschung (DKVF)

Published
2018
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37. Prognose der Krebsinzidenz und -mortalität in Hamburg für das Jahr 2030

Author

Waldmann, Annika, Erb, Cynthia, Fertmann, Regina, and Nennecke, Alice

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Aktuell werden in Hamburg jährlich rund 10.500 Krebsneuerkrankungen diagnostiziert und etwa 4.515 Personen versterben infolge von Krebs. Angesichts des demografischen Wandels und einer – für viele Krebsarten zutreffenden – höheren Erkrankungs- und Sterbewahrscheinlichkeit[zum vollständigen Text gelangen Sie über die oben angegebene URL], 17. Deutscher Kongress für Versorgungsforschung (DKVF)

Published
2018

38. Wie häufig kommen seltene Krebserkrankungen in Hamburg vor?

Author

Waldmann, A and Nennecke, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Statistisch gesehen wird in Deutschland jede zweite Frau und jeder zweite Mann im Laufe des Lebens mit einer Krebsdiagnose konfrontiert. In Hamburg machen die je drei häufigsten Lokalisationen (Brust / Prostata, Darm, Lunge) bei Frauen rund 52 % und bei Männern 45 %[zum vollständigen Text gelangen Sie über die oben angegebene URL], 17. Deutscher Kongress für Versorgungsforschung (DKVF)

Published
2018
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39. Klinische Krebsregistrierung – Jahresbericht 2017 des Hamburgischen Krebsregisters

Author

Abou-Deif, O, Nennecke, A, and Löhden, I

Subjects
Medizinische Dokumentation, ddc: 610, Medizinische Informatik, 610 Medical sciences, Medicine
Abstract

Einleitung: Mit der Novellierung des Hamburgischen Krebsregistergesetzes (HmbKrebsRG) Im Juli 2014 wurde das bis dahin epidemiologisch arbeitende Krebsregister der Stadt Hamburg in ein integriertes klinisch-epidemiologisches Register überführt. § 6 Abs. 2 HmbKrebsRG sieht neben der drei-jährlichen[zum vollständigen Text gelangen Sie über die oben angegebene URL], 63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)

Published
2018
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40. The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2)

Author

Matz, Melissa, Coleman, Michel P, Sant, Milena, Chirlaque, Maria Dolores, Visser, Otto, Gore, Martin, Allemani, Claudia, Bouzbid, S, Hamdi-chérif, M, Zaidi, Z, Bah, E, Swaminathan, R, Nortje, Sh, El Mistiri, Mm, Bayo, S, Malle, B, Manraj, Ss, Sewpaul-sungkur, R, Fabowale, A, Ogunbiyi, Oj, Bradshaw, D, Somdyala, Nim, Stefan, Dc, Abdel-rahman, M, Jaidane, L, Mokni, M, Kumcher, I, Moreno, F, González, Ms, Laura, Ea, Espinola, Sb, Calabrano, Gh, Carballo Quintero, B, Fita, R, Garcilazo, Da, Giacciani, Pl, Diumenjo, Mc, Laspada, Wd, Green, Ma, Lanza, Mf, Ibañez, Sg, Lima, Ca, Lobo De Oliveira, E, Daniel, C, Scandiuzzi, C, De Souza, Pcf, Melo, Cd, Del Pino, K, Laporte, C, Curado, Mp, De Oliveira, Jc, Veneziano, Cla, Veneziano, Db, Latorre, Mrdo, Tanaka, Lf, Azevedo E. Silva, G, Galaz, Jc, Moya, Ja, Herrmann, Da, Vargas, S, Herrera, Vm, Uribe, Cj, Bravo, Le, Arias-ortiz, Ne, Jurado, Dm, Yépez, Mc, Galán, Yh, Torres, P, Martínez-reyes, F, Pérez-meza, Ml, Jaramillo, L, Quinto, R, Cueva, P, Yépez, Jg, Torres-cintrón, Cr, Tortolero-luna, G, Alonso, R, Barrios, E, Nikiforuk, C, Shack, L, Coldman, Aj, Woods, Rr, Noonan, G, Turner, D, Kumar, E, Zhang, B, Mccrate, Fr, Ryan, S, Hannah, H, Dewar, Rad, Macintyre, M, Lalany, A, Ruta, M, Marrett, L, Nishri, De, Mcclure, C, Vriends, Ka, Bertrand, C, Louchini, R, Robb, K, Stuart-panko, H, Demers, S, Wright, S, George, Jt, Shen, X, Brockhouse, Jt, O'brien, Dk, Ward, Kc, Almon, L, Bates, J, Rycroft, R, Mueller, L, Phillips, C, Brown, H, Cromartie, B, Schwartz, Ag, Vigneau, F, Mackinnon, Ja, Wohler, B, Bayakly, Ar, Clarke, Ca, Glaser, Sl, West, D, Green, Md, Hernandez, By, Johnson, Cj, Jozwik, D, Charlton, Me, Lynch, Cf, Huang, B, Tucker, Tc, Deapen, D, Liu, L, Hsieh, Mc, Wu, Xc, Stern, K, Gershman, St, Knowlton, Rc, Alverson, J, Copeland, Ge, Rogers, Db, Lemons, D, Williamson, Ll, Hood, M, Hosain, Gm, Rees, Jr, Pawlish, Ks, Stroup, A, Key, C, Wiggins, C, Kahn, Ar, Schymura, Mj, Leung, G, Rao, C, Giljahn, L, Warther, B, Pate, A, Patil, M, Schubert, Ss, Rubertone, Jj, Slack, Sj, Fulton, Jp, Rousseau, Dl, Janes, Ta: Schwartz, Bolick, Sw, Hurley, Dm, Richards, J, Whiteside, Ma, Nogueira, Lm, Herget, K, Sweeney, C, Martin, J, Wang, S, Harrelson, Dg, Keitheri Cheteri, Mb, Farley, S, Hudson, Ag, Borchers, R, Stephenson, L, Espinoza, Jr, Weir, Hk, Edwards, Bk, Wang, N, Yang, L, Chen, Js, Song, Gh, Gu, Xp, Zhang, P, Ge, Hm, Zhao, Dl, Zhang, Jh, Zhu, Fd, Tang, Jg, Shen, Y, Wang, J, Li, Ql, Yang, Xp, Dong, J, Li, W, Cheng, Lp, Chen, Jg, Huang, Qh, Huang, Sq, Guo, Gp, Wei, K, Chen, Wq, Zeng, H, Demetriou, Av, Pavlou, P, Mang, Wk, Ngan, Kc, Kataki, Ac, Krishnatreya, M, Jayalekshmi, Pa, Sebastian, P, Sapkota, Sd, Verma, Y, Nandakumar, A, Suzanna, E, Keinan-boker, L, Silverman, Bg, Ito, H, Nakagawa, H, Hattori, M, Kaizaki, Y, Sugiyama, H, Utada, M, Katayama, K, Narimatsu, H, Kanemura, S, Koike, T, Miyashiro, I, Yoshii, M, Oki, I, Shibata, A, Matsuda, T, Nimri, O, Ab Manan, A, Bhoo-pathy, N, Tuvshingerel, S, Chimedsuren, O, Al Khater, Ahm, Al-eid, H, Jung, Kw, Won, Yj, Chiang, Cj, Lai, Ms, Suwanrungruang, K, Wiangnon, S, Daoprasert, K, Pongnikorn, D, Geater, Sl, Sriplung, H, Eser, S, Yakut, Ci, Hackl, M, Mühlböck, H, Oberaigner, W, Zborovskaya, Aa, Aleinikova, Ov, Henau, K, Van Eycken, L, Dimitrova, N, Valerianova, Z, Šekerija, M, Zvolský, M, Engholm, G, Storm, H, Innos, K, Mägi, M, Malila, N, Seppä, K, Jégu, J, Velten, M, Cornet, E, Troussard, X, Bouvier, Am, Faivre, J, Guizard, Av, Bouvier, V, Launoy, G, Arveux, P, Maynadié, M, Mounier, M, Fournier, E, Woronoff, As, Daoulas, M, Clavel, J, Le Guyader-peyrou, S, Monnereau, A, Trétarre, B, Colonna, M, Cowppli-bony, A, Molinié, F, Bara, S, Degré, D, Ganry, O, Lapôtre-ledoux, B, Grosclaude, P, Estève, J, Bray, F, Piñeros, M, Sassi, F, Stabenow, R, Eberle, A, Erb, C, Nennecke, A, Kieschke, J, Sirri, E, Kajueter, H, Emrich, K, Zeissig, Sr, Holleczek, B, Eisemann, N, Katalinic, A, Brenner, H, Asquez, Ra, Kumar, V, Ólafsdóttir, Ej, Tryggvadóttir, L, Comber, H, Walsh, Pm, Sundseth, H, Devigili, E, Mazzoleni, G, Giacomin, A, DI BELLA, Francesca, Castaing, M, Sutera, A, Gola, G, Ferretti, S, Serraino, D, Zucchetto, A, Lillini, R, Vercelli, M, Busco, S, Pannozzo, F, Vitarelli, S, Ricci, P, Pascucci, C, Autelitano, M, Cirilli, C, Federico, M, FUSCO, Elena Maria, Vitale, Mf, Usala, M, Cusimano, R, Mazzucco, W, Michiara, M, Sgargi, P, Maule, Mm, Sacerdote, C, Tumino, R, Di Felice, E, Vicentini, M, Falcini, F, Cremone, L, Budroni, M, Cesaraccio, R, Contrino, Ml, Tisano, F, Fanetti, Ac, Maspero, S, Candela, G, Scuderi, T, Gentilini, Ma, Piffer, S, Rosso, S, Sacchetto, L, Caldarella, A, La Rosa, F, Stracci, F, Contiero, P, Tagliabue, G, Dei Tos, Ap, Zorzi, M, Zanetti, R, Baili, P, Berrino, F, Gatta, G, Sant, M, Capocaccia, R, De Angelis, R, Liepina, E, Maurina, A, Smailyte, G, Agius, D, Calleja, N, Siesling, S, Visser, O, Larønningen, S, Møller, B, Dyzmann-sroka, A, Trojanowski, M, Góźdż, S, Mężyk, R, Grądalska-lampart, M, Radziszewska, Au, Didkowska, Ja, Wojciechowska, U, Błaszczyk, J, Kępska, K, Bielska-lasota, M, Kwiatkowska, K, Forjaz, G, Rego, Ra, Bastos, J, Silva, Ma, Antunes, L, Bento, Mj, Mayer-da-silva, A, Miranda, A, Coza, D, Todescu, Ai, Valkov, My, Adamcik, J, Safaei Diba, C, Primic-žakelj, M, Žagar, T, Stare, J, Almar, E, Mateos, A, Quirós, Jr, Bidaurrazaga, J, Larrañaga, N, Díaz García, Jm, Marcos, Ai, Marcos-gragera, R, Vilardell Gil, Ml, Molina, E, Sánchez, Mj, Franch Sureda, P, Ramos Montserrat, M, Chirlaque, Md, Navarro, C, Ardanaz, Ee, Moreno-iribas, Cc, Fernández-delgado, R, Peris-bonet, R, Galceran, J, Khan, S, Lambe, M, Camey, B, Bouchardy, C, Usel, M, Ess, Sm, Herrmann, C, Bulliard, Jl, Maspoli-conconi, M, Frick, H, Kuehni, Ce, Schindler, M, Bordoni, A, Spitale, A, Chiolero, A, Konzelmann, I, Dehler, Si, Matthes, Kl, Rashbass, J, Stiller, Ca, Fitzpatrick, D, Gavin, A, Bannon, F, Black, Rj, Brewster, Dh, Huws, Dw, White, C, Finan, P, Allemani, C, Bonaventure, A, Carreira, H, Coleman, Mp, Di Carlo, V, Harewood, R, Liu, K, Matz, M, Montel, L, Nikšić, M, Rachet, B, Sanz, N, Spika, D, Stephens, R, Peake, M, Chalker, E, Newman, L, Baker, D, Soeberg, Mj, Aitken, J, Scott, C, Stokes, Bc, Venn, A, Farrugia, H, Giles, Gg, Threlfall, T, Currow, D, You, H, Hendrix, J, Lewis, C., Matz, M., Coleman, M., Sant, M., Chirlaque, M., Visser, O., Gore, M., Allemani, C., Bouzbid, S., Hamdi-chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S., El Mistiri, M., Bayo, S., Malle, B., Manraj, S., Sewpaul-sungkur, R., Fabowale, A., Ogunbiyi, O., Bradshaw, D., Somdyala, N., Stefan, D., Abdel-rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M., Laura, E., Espinola, S., Calabrano, G., Carballo Quintero, B., Fita, R., Garcilazo, D., Giacciani, P., Diumenjo, M., Laspada, W., Green, M., Lanza, M., Ibañez, S., Lima, C., Lobo De Oliveira, E., Daniel, C., Scandiuzzi, C., De Souza, P., Melo, C., Del Pino, K., Laporte, C., Curado, M., De Oliveira, J., Veneziano, C., Veneziano, D., Latorre, M., Tanaka, L., Azevedo E. Silva, G., Galaz, J., Moya, J., Herrmann, D., Vargas, S., Herrera, V., Uribe, C., Bravo, L., Arias-ortiz, N., Jurado, D., Yépez, M., Galán, Y., Torres, P., Martínez-reyes, F., Pérez-meza, M., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J., Torres-cintrón, C., Tortolero-luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A., Woods, R., Noonan, G., Turner, D., Kumar, E., Zhang, B., Mccrate, F., Ryan, S., Hannah, H., Dewar, R., Macintyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D., Mcclure, C., Vriends, K., Bertrand, C., Louchini, R., Robb, K., Stuart-panko, H., Demers, S., Wright, S., George, J., Shen, X., Brockhouse, J., O'Brien, D., Ward, K., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A., Vigneau, F., Mackinnon, J., Wohler, B., Bayakly, A., Clarke, C., Glaser, S., West, D., Hernandez, B., Johnson, C., Jozwik, D., Charlton, M., Lynch, C., Huang, B., Tucker, T., Deapen, D., Liu, L., Hsieh, M., Xc, W., Stern, K., Gershman, S., Knowlton, R., Alverson, J., Copeland, G., Rogers, D., Lemons, D., Williamson, L., Hood, M., Hosain, G., Rees, J., Pawlish, K., Stroup, A., Key, C., Wiggins, C., Kahn, A., Schymura, M., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S., Rubertone, J., Slack, S., Fulton, J., Rousseau, D., Janes, Ta:, S., Sm, Bolick, S., Hurley, D., Richards, J., Whiteside, M., Nogueira, L., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D., Keitheri Cheteri, M., Farley, S., Hudson, A., Borchers, R., Stephenson, L., Espinoza, J., Weir, H., Edwards, B., Wang, N., Yang, L., Chen, J., Song, G., Xp, G., Zhang, P., Hm, G., Zhao, D., Zhang, J., Zhu, F., Tang, J., Shen, Y., Wang, J., Ql, L., Yang, X., Dong, J., Li, W., Cheng, L., Huang, Q., Huang, S., Guo, G., Wei, K., Chen, W., Zeng, H., Demetriou, A., Pavlou, P., Mang, W., Ngan, K., Kataki, A., Krishnatreya, M., Jayalekshmi, P., Sebastian, P., Sapkota, S., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-boker, L., Silverman, B., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Bhoo-pathy, N., Tuvshingerel, S., Chimedsuren, O., Al Khater, A., Al-eid, H., Jung, K., Won, Y., Chiang, C., Lai, M., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S., Sriplung, H., Eser, S., Yakut, C., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A., Aleinikova, O., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A., Faivre, J., Guizard, A., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A., Daoulas, M., Clavel, J., Le Guyader-peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R., Kumar, V., Ólafsdóttir, E., Tryggvadóttir, L., Comber, H., Walsh, P., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., DI BELLA, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, E., Vitale, M., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M., Tisano, F., Fanetti, A., Maspero, S., Candela, G., Scuderi, T., Gentilini, M., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Larønningen, S., Møller, B., Dyzmann-sroka, A., Trojanowski, M., Góźdż, S., Mężyk, R., Grądalska-lampart, M., Radziszewska, A., Didkowska, J., Wojciechowska, U., Błaszczyk, J., Kępska, K., Bielska-lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R., Bastos, J., Silva, M., Antunes, L., Bento, M., Mayer-da-silva, A., Miranda, A., Coza, D., Todescu, A., Valkov, M., Adamcik, J., Safaei Diba, C., Primic-žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J., Bidaurrazaga, J., Larrañaga, N., Díaz García, J., Marcos, A., Marcos-gragera, R., Vilardell Gil, M., Molina, E., Sánchez, M., Franch Sureda, P., Ramos Montserrat, M., Navarro, C., Ardanaz, E., Moreno-iribas, C., Fernández-delgado, R., Peris-bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S., Herrmann, C., Bulliard, J., Maspoli-conconi, M., Frick, H., Kuehni, C., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S., Matthes, K., Rashbass, J., Stiller, C., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R., Brewster, D., Huws, D., White, C., Finan, P., Bonaventure, A., Carreira, H., Di Carlo, V., Harewood, R., Liu, K., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Chalker, E., Newman, L., Baker, D., Soeberg, M., Aitken, J., Scott, C., Stokes, B., Venn, A., Farrugia, H., Giles, G., Threlfall, T., Currow, D., You, H., Hendrix, J., and Lewis, C.

Subjects
Epidemiology, Histology, Morphology, Ovarain cancer, Worldwide, 0301 basic medicine, Oncology, Pathology, endocrine system diseases, Sex Cord-Gonadal Stromal Tumors, Carcinoma, Ovarian Epithelial, 0302 clinical medicine, Neoplasms, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, education.field_of_study, Adolescent, Adult, Aged, Female, Humans, Middle Aged, Neoplasms, Germ Cell and Embryonal, Obstetrics and Gynecology, Glandular and Epithelial, female genital diseases and pregnancy complications, Transitional cell carcinoma, 030220 oncology & carcinogenesis, Clear cell carcinoma, Human, endocrine system, medicine.medical_specialty, Population, Socio-culturale, 03 medical and health sciences, Internal medicine, medicine, education, Mixed tumor, business.industry, Ovarian Neoplasm, Sex Cord-Gonadal Stromal Tumor, medicine.disease, 030104 developmental biology, Germ Cell and Embryonal, Ovarian cancer, business
Abstract

OBJECTIVE: Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. METHODS: The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995-2009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. RESULTS: During 2005-2009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time. CONCLUSIONS: The distribution of ovarian cancer histology varies widely worldwide. Type I epithelial, germ cell and sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions.

Published
2016

43. Mesothelioma and thymic tumors: Treatment challenges in (outside) a network setting

Author

Silvano Piffer, Kamila Kepska, K. Henau, Bénédicte Lapôtre-Ledoux, Maja Primic-Zakelj, Anna Gavin, Anselmo Madeddu, Neville Calleja, Fabio Pannozzo, M Usala, Marc Colonna, Marià Carulla, Dyfed Wyn Huws, Jon G. Jonasson, Xavier Troussard, Antonio Ziino, Silvia Rossi, Francesco Vitale, Conchi Moreno-Iribas, Riccardo Capocaccia, Adriano Giacomin, Isabelle Konzelmann, J. Błaszczyk, Claire Schvartz, Anne-Marie Bouvier, Mohsen Mousavi, Anne-Valérie Guizard, Chakameh Safaei Diba, Maarit K. Leinonen, Laura Botta, Nadya Dimitrova, Diego Serraino, Arantza Lopez de Munain, Gemma Gatta, Anne-Sophie Woronoff, Elizabeth Van Eycken, L Benfatto, E Marani, Nea Malila, Ladislav Dušek, Mariano Santaquilani, Harry Comber, Arturo Iannelli, José María Díaz García, Maria José Bento, M. Robaszkiewicz, Stanisław Góźdź, M.A. Gentilini, Stefano Ferretti, Ana Miranda, Andrea Tavilla, Paolo Ricci, Silvia Ess, Diego Salmerón, M Autelitano, Carmen Navarro, Alessandro Barchielli, Daniela Pierannunzio, Gianbattista Spagnoli, Giedre Smailyte, Santa Pildava, Roland Stabenow, Nerea Larrañaga, Arnold Knijn, Simona Bara, Flavio Sensi, Nicolas Girard, Alice Nennecke, Fabrizio Stracci, Giovanna Tagliabue, Ana Torrella-Ramos, Massimo Rugge, Bernd Holleczek, Andrea Bordoni, Michel Velten, Rosario Tumino, David H. Brewster, Jadwiga Rachtan, Alain Monnereau, M. Sekerija, Jan Heidrich, Sabine Luttmann, Kerri Clough-Gorr, Christine Bouchardy, Véronique Bouvier, Valerio Gennaro, Rosa Filiberti, Lucia Mangone, Patrick Arveux, Brigitte Trétarre, Isabelle Baldi, Roberta De Angelis, Martina Imbimbo, Margit Mägi, Marc Maynadié, Jutta Engel, Guido Mazzoleni, Otto Visser, María José Sánchez, Jean-Michel Maury, Marina Chiara Garassino, Rafael Marcos-Gragera, E. Almar, Gabriele Schubert-Fritschle, Sandra Mallone, Jaume Galceran, Pascale Grosclaude, S Maspero, Jem Rashbass, Tom Børge Johannesen, Gonçalo Forjaz de Lacerda, Maria Michiara, Magdalena Bielska-Lasota, Ellen Benhamou, Annalisa Trama, Florence Molinié, Pina Candela, Monika Hackl, Fabio Falcini, Ian Kunkler, Antonella Sutera Sardo, Mario Fusco, Imbimbo, M, Maury, J, Grassino, M, Girard, N, and Vitale, F

Subjects
0301 basic medicine, Mesothelioma, medicine.medical_specialty, International Cooperation, Pleural Neoplasms, MEDLINE, Socio-culturale, Context (language use), Translational research, Disease, Social Networking, 03 medical and health sciences, 0302 clinical medicine, Multidisciplinary approach, Medicine, Humans, Pleural Neoplasm, Intensive care medicine, business.industry, General Medicine, Thymus Neoplasms, medicine.disease, Clinical trial, Europe, Survival Rate, 030104 developmental biology, Clinical research, Oncology, 030220 oncology & carcinogenesis, Surgery, business, Delivery of Health Care, mesothelioma, thymic tumours, clinical trials, Human
Abstract

The management of patients with mesothelioma and thymic malignancy requires continuous multidisciplinary expertise at any step of the disease. A dramatic improvement in our knowledge has occurred in the last few years, through the development of databases, translational research programs, and clinical trials. Access to innovative strategies represents a major challenge, as there is a lack of funding for clinical research in rare cancers and their rarity precludes the design of robust clinical trials that could lead to specific approval of drugs. In this context, patient-centered initiatives, such as the establishment of dedicated networks, are warranted. International societies, such as IMIG (International Mesothelioma Interest Group) and ITMIG (International Thymic Malignancy Interest Group) provide infrastructure for global collaboration, and there are many advantages to having strong regional groups working on the same issues. There may be regional differences in risk factors, susceptibility, management and outcomes. The ability to address questions both regionally as well as globally is ideal to develop a full understanding of mesothelioma and thymic malignancies. In Europe, through the integration of national networks with EURACAN, the collaboration with academic societies and international groups, the development of networks in thoracic oncology provides multiplex integration of clinical care and research, ultimately ensuring equal access to high quality care to all patients, with the opportunity of conducting high level clinical and translational research projects.

Published
2017

44. Survival of patients with lymphoplasmacytic lymphoma and solitary plasmacytoma in Germany and the United States of America in the early 21st century

Author

Weberpals, Janick, Pulte, Dianne, Jansen, Lina, Luttmann, Sabine, Holleczek, Bernd, Nennecke, Alice, Ressing, Meike, Katalinic, Alexander, Merz, Maximilian, Brenner, Hermann, and GEKID Cancer Survival Working Group

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Adolescent, Population, Improved survival, Lymphoplasmacytic Lymphoma, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Germany, medicine, Humans, Registries, education, Online Only Articles, Multiple myeloma, Aged, education.field_of_study, business.industry, Hematology, Middle Aged, medicine.disease, United States, Survival Rate, 030220 oncology & carcinogenesis, Population Surveillance, Female, Waldenstrom Macroglobulinemia, business, Solitary plasmacytoma, 030215 immunology, Plasmacytoma, SEER Program
Abstract

Population-level survival has increased for a number of hematologic malignancies.[1][1]–[3][2] Multiple myeloma, in particular, has seen improved survival both in clinical trials[4][3]–[8][4] and on the population level.[3][2],[9][5]–[11][6] However, it is not known whether the changes in

Published
2017

45. Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries

Author

Bonaventure, Audrey, Harewood, Rhea, Stiller, Charles A, Gatta, Gemma, Clavel, Jacqueline, Stefan, Daniela C, Carreira, Helena, Spika, Devon, Marcos Gragera, Rafael, Peris Bonet, Rafael, Piñeros, Marion, Sant, Milena, Kuehni, Claudia E, Murphy, Michael F. G, Coleman, Michel P, Allemani, Claudia, Bouzbid, S., Hamdi Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S. H., El Mistiri, M. M., Bayo, S., Malle, B., Manraj, S. S., Sewpaul Sungkur, R., Fabowale, Null, Ogunbiyi, O. J., Bradshaw, D., Somdyala, N. I. M., Stefan, D. C., Abdel Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M. S., Laura, E. A., Espinola, S. B., Calabrano, G. H., Carballo Quintero, B., Fita, R., Garcilazo, D. A., Giacciani, P. L., Diumenjo, M. C., Laspada, W. D., Green, M. A., Lanza, M. F., Ibañez, S. G., Lima, C. A., de Oliveira, E. Lobo, Daniel, C., Scandiuzzi, C., De Souza, P. C. F., Melo, C. D., Del Pino, K., Laporte, C., Curado, M. P., de Oliveira, J. C., Veneziano, C. L. A., Veneziano, D. B., Alexandre, T. S., Verdugo, A. S., Azevedo e. Silva, G., Galaz, J. C., Moya, J. A., Herrmann, D. A., Vargas, S., Herrera, V. M., Uribe, C. J., Bravo, L. E., Arias Ortiz, N. E., Jurado, D. M., Yépez, M. C., Galán, Y. H., Torres, P., Martínez Reyes, F., Pérez Meza, M. L., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J. G., Torres Cintrón, C. R., Tortolero Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A. J., Woods, R. R., Noonan, G., Turner, D., Kumar, E., Zhang, B., Mccrate, F. R., Ryan, S., Hannah, H., Dewar, R. A. D., Macintyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D. E., Mcclure, C., Vriends, K. A., Bertrand, C., Louchini, R., Robb, K. I., Stuart Panko, H., Demers, S., Wright, S., George, J. T., Shen, X., Brockhouse, J. T., O'Brien, D. K., Ward, K. C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A. G., Vigneau, F., Mackinnon, J. A., Wohler, B., Bayakly, A. R., Clarke, C. A., Glaser, S. L., West, D., Green, M. D., Hernandez, B. Y., Johnson, C. J., Jozwik, D., Charlton, M. E., Lynch, C. F., Huang, B., Tucker, T. C., Deapen, D., Liu, L., Hsieh, M. C., X. C., Wu, Stern, K., Gershman, S. T., Knowlton, R. C., Alverson, J., Copeland, G. E., Rogers, D. B., Lemons, D., Williamson, L. L., Hood, M., Hosain, G. M., Rees, J. R., Pawlish, K. S., Stroup, A., Key, C., Wiggins, C., Kahn, A. R., Schymura, M. J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S. S., Rubertone, J. J., Slack, S. J., Fulton, J. P., Rousseau, D. L., Janes, T. A., Schwartz, S. M., Bolick, S. W., Hurley, D. M., Richards, J., Whiteside, M. A., Nogueira, L. M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D. G., Cheteri, MB Keitheri, Farley, S., Hudson, A. G., Borchers, R., Stephenson, L., Espinoza, J. R., Weir, H. K., Edwards, B. K., Wang, N., Yang, L., Chen, J. S., Song, G. H., X. P., Gu, Zhang, P., H. M., Ge, Zhao, D. L., Zhang, J. H., Zhu, F. D., Tang, J. G., Shen, Y., Wang, J., Q. L., Li, Yang, X. P., Dong, J., Li, W., Cheng, L. P., Chen, J. G., Huang, Q. H., Huang, S. Q., Guo, G. P., Wei, K., Chen, W. Q., Zeng, H., Demetriou, A. V., Pavlou, P., Mang, W. K., Ngan, K. C., Kataki, A. C., Krishnatreya, M., Jayalekshmi, P. A., Sebastian, P., Sapkota, S. D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan Boker, L., Silverman, B. G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Pathy, N. Bhoo, Chimedsuren, O., Tuvshingerel, S., Al Khater, A. H. M., Al Eid, H., Jung, K. W., Won, Y. J., Chiang, C. J., Lai, M. S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S. L., Sriplung, H., Eser, S., Yakut, C. I., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A. A., Aleinikova, O. V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A. M., Faivre, J., Guizard, A. V., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A. S., Daoulas, M., Clavel, J., Le Guyader Peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli Bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre Ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S. R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R. A., Kumar, V., Ólafsdóttir, E. J., Tryggvadóttir, L., Comber, H., Walsh, P. M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M. F., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, MILENA MARIA, Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M. L., Tisano, F., Fanetti, A. C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M. A., Piffer, S., Rosso, S., Sacchetto, Lidia, Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A. P., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann Sroka, A., Trojanowski, M., Gózdz, S., Mezyk, R., Gradalska Lampart, M., Radziszewska, A. U., Didkowska, J. A., Wojciechowska, U., Blaszczyk, J., Kepska, K., Bielska Lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R. A., Bastos, J., Silva, M. A., Antunes, L., Bento, M. J., Mayer da Silva, A., Miranda, A., Coza, D., Todescu, A. I., Valkov, M. Y., Adamcik, J., Safaei Diba, C., Primic Žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J. R., Bidaurrazaga, J., Larrañaga, N., Díaz García, J. M., Marcos, A. I., Marcos Gragera, R., Vilardell Gil, M. L., Molina, E., Sánchez, M. J., Sureda, P. Franch, Montserrat, M. Ramos, Chirlaque, M. D., Navarro, C., Ardanaz, E. E., Moreno Iribas, C. C., Fernández Delgado, R., Peris Bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S. M., Herrmann, C., Bulliard, J. L., Maspoli Conconi, M., Frick, H., Kuehni, C. E., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S. I., Matthes, K. L., Rashbass, J., Stiller, C. A., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R. J., Brewster, D. H., Huws, D. W., White, C., Finan, P., Allemani, C., Bonaventure, A., Carreira, H., Coleman, M. P., Di Carlo, V., Harewood, R., Liu, K., Matz, M., Montel, L., Nikšic, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Murphy, M. F. G., Chalker, E., Newman, L., Baker, D., Soeberg, M. J., Aitken, J., Scott, C., Stokes, B. C., Venn, A., Farrugia, H., Giles, G. G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Latorre, M. R. D. O., and Tanaka, L. F.

Subjects
Hematology
Published
2017

46. Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)

Author

Matz, M., Coleman, M., Carreira, H., Salmerã³n, D., Chirlaque, M., Allemani, C., Bouzbid, S., Hamdi-chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S., El Mistiri, M., Bayo, S., Malle, B., Manraj, S., Sewpaul-sungkur, R., Fabowale, A., Ogunbiyi, O., Bradshaw, D., Somdyala, N., Stefan, D., Abdel-rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M., Laura, E., Espinola, S., Calabrano, G., Carballo Quintero, B., Fita, R., Garcilazo, D., Giacciani, P., Diumenjo, M., Laspada, W., Green, M., Lanza, M., Ibañez, S., Lima, C., Lobo De Oliveira, E., Daniel, C., Scandiuzzi, C., De Souza, P., Melo, C., Del Pino, K., Laporte, C., Curado, M., De Oliveira, J., Veneziano, C., Veneziano, D., Latorre, M., Tanaka, L., Azevedo E. Silva, G., Galaz, J., Moya, J., Herrmann, D., Vargas, S., Herrera, V., Uribe, C., Bravo, L., Arias-ortiz, N., Jurado, D., Yépez, M., Galán, Y., Torres, P., Martínez-reyes, F., Pérez-meza, M., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J., Torres-cintrón, C., Tortolero-luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A., Woods, R., Noonan, G., Turner, D., Kumar, E., Zhang, B., Mccrate, F., Ryan, S., Hannah, H., Dewar, R., Macintyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D., Mcclure, C., Vriends, K., Bertrand, C., Louchini, R., Robb, K., Stuart-panko, H., Demers, S., Wright, S., George, J., Shen, X., Brockhouse, J., O'Brien, D., Ward, K., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A., Vigneau, F., Mackinnon, J., Wohler, B., Bayakly, A., Clarke, C., Glaser, S., West, D., Hernandez, B., Johnson, C., Jozwik, D., Charlton, M., Lynch, C., Huang, B., Tucker, T., Deapen, D., Liu, L., Hsieh, M., Xc, W., Stern, K., Gershman, S., Knowlton, R., Alverson, J., Copeland, G., Rogers, D., Lemons, D., Williamson, L., Hood, M., Hosain, G., Rees, J., Pawlish, K., Stroup, A., Key, C., Wiggins, C., Kahn, A., Schymura, M., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S., Rubertone, J., Slack, S., Fulton, J., Rousseau, D., Janes, Ta:, S., Bolick, S., Hurley, D., Richards, J., Whiteside, M., Nogueira, L., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D., Keitheri Cheteri, M., Farley, S., Hudson, A., Borchers, R., Stephenson, L., Espinoza, J., Weir, H., Edwards, B., Wang, N., Yang, L., Chen, J., Song, G., Xp, G., Zhang, P., Hm, G., Zhao, D., Zhang, J., Zhu, F., Tang, J., Shen, Y., Wang, J., Ql, L., Yang, X., Dong, J., Li, W., Cheng, L., Huang, Q., Huang, S., Guo, G., Wei, K., Chen, W., Zeng, H., Demetriou, A., Pavlou, P., Mang, W., Ngan, K., Kataki, A., Krishnatreya, M., Jayalekshmi, P., Sebastian, P., Sapkota, S., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-boker, L., Silverman, B., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Bhoo-pathy, N., Tuvshingerel, S., Chimedsuren, O., Al Khater, A., Al-eid, H., Jung, K., Won, Y., Chiang, C., Lai, M., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S., Sriplung, H., Eser, S., Yakut, C., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A., Aleinikova, O., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A., Faivre, J., Guizard, A., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A., Daoulas, M., Clavel, J., Le Guyader-peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R., Kumar, V., Ólafsdóttir, E., Tryggvadóttir, L., Comber, H., Walsh, P., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M., Tisano, F., Fanetti, A., Maspero, S., Candela, G., Scuderi, T., Gentilini, M., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann-sroka, A., Trojanowski, M., Góźdż, S., Mężyk, R., Grądalska-lampart, M., Radziszewska, A., Didkowska, J., Wojciechowska, U., Błaszczyk, J., Kępska, K., Bielska-lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R., Bastos, J., Silva, M., Antunes, L., Bento, M., Mayer-da-silva, A., Miranda, A., Coza, D., Todescu, A., Valkov, M., Adamcik, J., Safaei Diba, C., Primic-žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J., Bidaurrazaga, J., Larrañaga, N., Díaz García, J., Marcos, A., Marcos-gragera, R., Vilardell Gil, M., Molina, E., Sánchez, M., Franch Sureda, P., Ramos Montserrat, M., Navarro, C., Ardanaz, E., Moreno-iribas, C., Fernández-delgado, R., Peris-bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S., Herrmann, C., Bulliard, J., Maspoli-conconi, M., Frick, H., Kuehni, C., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S., Matthes, K., Rashbass, J., Stiller, C., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R., Brewster, D., Huws, D., White, C., Finan, P., Bonaventure, A., Di Carlo, V., Harewood, R., Liu, K., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Chalker, E., Newman, L., Baker, D., Soeberg, M., Aitken, J., Scott, C., Stokes, B., Venn, A., Farrugia, H., Giles, G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Matz, M, Coleman, M, Carreira, H, Salmeròn, D, Chirlaque, M, Allemani, C, and Mazzucco, W

Subjects
0301 basic medicine, Oncology, Settore MED/42 - Igiene Generale E Applicata, 0302 clinical medicine, morphology, 80 and over, Stage (cooking), Aged, 80 and over, Ovarian Neoplasms, education.field_of_study, epidemiology, histology, ovarian cancer, stage, survival, Adolescent, Adult, Aged, Female, Humans, Middle Aged, Neoplasm Staging, Obstetrics and Gynecology, Transitional cell carcinoma, 030220 oncology & carcinogenesis, Clear cell carcinoma, Human, medicine.medical_specialty, Population, Socio-culturale, Article, 03 medical and health sciences, Internal medicine, medicine, ovarian cancer, epidemiology, survival, stage, morphology, histology, education, Cancer staging, Gynecology, business.industry, Ovarian Neoplasm, Cancer, medicine.disease, Cancer registry, 030104 developmental biology, Ovarian cancer, business
Abstract

Objective Ovarian cancer comprises several histological groups with widely differing levels of survival. We aimed to explore international variation in survival for each group to help interpret international differences in survival from all ovarian cancers combined. We also examined differences in stage-specific survival. Methods The CONCORD programme is the largest population-based study of global trends in cancer survival, including data from 60 countries for 695,932 women (aged 15–99years) diagnosed with ovarian cancer during 1995–2009. We defined six histological groups: type I epithelial, type II epithelial, germ cell, sex cord-stromal, other specific non-epithelial and non-specific morphology, and estimated age-standardised 5-year net survival for each country by histological group. We also analysed data from 67 cancer registries for 233,659 women diagnosed from 2001 to 2009, for whom information on stage at diagnosis was available. We estimated age-standardised 5-year net survival by stage at diagnosis (localised or advanced). Results Survival from type I epithelial ovarian tumours for women diagnosed during 2005–09 ranged from 40 to 70%. Survival from type II epithelial tumours was much lower (20–45%). Survival from germ cell tumours was higher than that of type II epithelial tumours, but also varied widely between countries. Survival for sex-cord stromal tumours was higher than for the five other groups. Survival from localised tumours was much higher than for advanced disease (80% vs. 30%). Conclusions There is wide variation in survival between histological groups, and stage at diagnosis remains an important factor in ovarian cancer survival. International comparisons of ovarian cancer survival should incorporate histology.

Published
2017

47. Erratum to 'Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)' [Gynecol. Oncol. 144 (2017) 396–404]

Author

Matz, Melissa, Coleman, Michel P, Carreira, Helena, Salmerã³n, Diego, Chirlaque, Maria Dolores, Allemani, Claudia, Bouzbid, S, Hamdi-chérif, M, Zaidi, Z, Bah, E, Swaminathan, R, Nortje, Sh, El Mistiri, Mm, Bayo, S, Malle, B, Manraj, Ss, Sewpaul-sungkur, R, Fabowale, A, Ogunbiyi, Oj, Bradshaw, D, Somdyala, Nim, Stefan, Dc, Abdel-rahman, M, Jaidane, L, Mokni, M, Kumcher, I, Moreno, F, González, Ms, Laura, Ea, Espinola, Sb, Calabrano, Gh, Carballo Quintero, B, Fita, R, Garcilazo, Da, Giacciani, Pl, Diumenjo, Mc, Laspada, Wd, Green, Ma, Lanza, Mf, Ibañez, Sg, Lima, Ca, Lobo De Oliveira, E, Daniel, C, Scandiuzzi, C, De Souza, Pcf, Melo, Cd, Del Pino, K, Laporte, C, Curado, Mp, De Oliveira, Jc, Veneziano, Cla, Veneziano, Db, Latorre, Mrdo, Tanaka, Lf, Azevedo E. Silva, G, Galaz, Jc, Moya, Ja, Herrmann, Da, Vargas, S, Herrera, Vm, Uribe, Cj, Bravo, Le, Arias-ortiz, Ne, Jurado, Dm, Yépez, Mc, Galán, Yh, Torres, P, Martínez-reyes, F, Pérez-meza, Ml, Jaramillo, L, Quinto, R, Cueva, P, Yépez, Jg, Torres-cintrón, Cr, Tortolero-luna, G, Alonso, R, Barrios, E, Nikiforuk, C, Shack, L, Coldman, Aj, Woods, Rr, Noonan, G, Turner, D, Kumar, E, Zhang, B, Mccrate, Fr, Ryan, S, Hannah, H, Dewar, Rad, Macintyre, M, Lalany, A, Ruta, M, Marrett, L, Nishri, De, Mcclure, C, Vriends, Ka, Bertrand, C, Louchini, R, Robb, K, Stuart-panko, H, Demers, S, Wright, S, George, Jt, Shen, X, Brockhouse, Jt, O'brien, Dk, Ward, Kc, Almon, L, Bates, J, Rycroft, R, Mueller, L, Phillips, C, Brown, H, Cromartie, B, Schwartz, Ag, Vigneau, F, Mackinnon, Ja, Wohler, B, Bayakly, Ar, Clarke, Ca, Glaser, Sl, West, D, Green, Md, Hernandez, By, Johnson, Cj, Jozwik, D, Charlton, Me, Lynch, Cf, Huang, B, Tucker, Tc, Deapen, D, Liu, L, Hsieh, Mc, Wu, Xc, Stern, K, Gershman, St, Knowlton, Rc, Alverson, J, Copeland, Ge, Rogers, Db, Lemons, D, Williamson, Ll, Hood, M, Hosain, Gm, Rees, Jr, Pawlish, Ks, Stroup, A, Key, C, Wiggins, C, Kahn, Ar, Schymura, Mj, Leung, G, Rao, C, Giljahn, L, Warther, B, Pate, A, Patil, M, Schubert, Ss, Rubertone, Jj, Slack, Sj, Fulton, Jp, Rousseau, Dl, Janes, Ta: Schwartz, Bolick, Sw, Hurley, Dm, Richards, J, Whiteside, Ma, Nogueira, Lm, Herget, K, Sweeney, C, Martin, J, Wang, S, Harrelson, Dg, Keitheri Cheteri, Mb, Farley, S, Hudson, Ag, Borchers, R, Stephenson, L, Espinoza, Jr, Weir, Hk, Edwards, Bk, Wang, N, Yang, L, Chen, Js, Song, Gh, Gu, Xp, Zhang, P, Ge, Hm, Zhao, Dl, Zhang, Jh, Zhu, Fd, Tang, Jg, Shen, Y, Wang, J, Li, Ql, Yang, Xp, Dong, J, Li, W, Cheng, Lp, Chen, Jg, Huang, Qh, Huang, Sq, Guo, Gp, Wei, K, Chen, Wq, Zeng, H, Demetriou, Av, Pavlou, P, Mang, Wk, Ngan, Kc, Kataki, Ac, Krishnatreya, M, Jayalekshmi, Pa, Sebastian, P, Sapkota, Sd, Verma, Y, Nandakumar, A, Suzanna, E, Keinan-boker, L, Silverman, Bg, Ito, H, Nakagawa, H, Hattori, M, Kaizaki, Y, Sugiyama, H, Utada, M, Katayama, K, Narimatsu, H, Kanemura, S, Koike, T, Miyashiro, I, Yoshii, M, Oki, I, Shibata, A, Matsuda, T, Nimri, O, Ab Manan, A, Bhoo-pathy, N, Tuvshingerel, S, Chimedsuren, O, Al Khater, Ahm, Al-eid, H, Jung, Kw, Won, Yj, Chiang, Cj, Lai, Ms, Suwanrungruang, K, Wiangnon, S, Daoprasert, K, Pongnikorn, D, Geater, Sl, Sriplung, H, Eser, S, Yakut, Ci, Hackl, M, Mühlböck, H, Oberaigner, W, Zborovskaya, Aa, Aleinikova, Ov, Henau, K, Van Eycken, L, Dimitrova, N, Valerianova, Z, Šekerija, M, Zvolský, M, Engholm, G, Storm, H, Innos, K, Mägi, M, Malila, N, Seppä, K, Jégu, J, Velten, M, Cornet, E, Troussard, X, Bouvier, Am, Faivre, J, Guizard, Av, Bouvier, V, Launoy, G, Arveux, P, Maynadié, M, Mounier, M, Fournier, E, Woronoff, As, Daoulas, M, Clavel, J, Le Guyader-peyrou, S, Monnereau, A, Trétarre, B, Colonna, M, Cowppli-bony, A, Molinié, F, Bara, S, Degré, D, Ganry, O, Lapôtre-ledoux, B, Grosclaude, P, Estève, J, Bray, F, Piñeros, M, Sassi, F, Stabenow, R, Eberle, A, Erb, C, Nennecke, A, Kieschke, J, Sirri, E, Kajueter, H, Emrich, K, Zeissig, Sr, Holleczek, B, Eisemann, N, Katalinic, A, Brenner, H, Asquez, Ra, Kumar, V, Ólafsdóttir, Ej, Tryggvadóttir, L, Comber, H, Walsh, Pm, Sundseth, H, Devigili, E, Mazzoleni, G, Giacomin, A, Bella, F, Castaing, M, Sutera, A, Gola, G, Ferretti, S, Serraino, D, Zucchetto, A, Lillini, R, Vercelli, M, Busco, S, Pannozzo, F, Vitarelli, S, Ricci, P, Pascucci, C, Autelitano, M, Cirilli, C, Federico, M, Fusco, M, Vitale, Mf, Usala, M, Cusimano, R, Mazzucco, W, Michiara, M, Sgargi, P, Maule, Mm, Sacerdote, C, Tumino, R, Di Felice, E, Vicentini, M, Falcini, F, Cremone, L, Budroni, M, Cesaraccio, R, Contrino, Ml, Tisano, F, Fanetti, Ac, Maspero, S, Candela, G, Scuderi, T, Gentilini, Ma, Piffer, S, Rosso, S, Sacchetto, L, Caldarella, A, La Rosa, F, Stracci, F, Contiero, P, Tagliabue, G, Dei Tos, Ap, Zorzi, M, Zanetti, R, Baili, P, Berrino, F, Gatta, G, Sant, M, Capocaccia, R, De Angelis, R, Liepina, E, Maurina, A, Smailyte, G, Agius, D, Calleja, N, Siesling, S, Visser, O, Larønningen, S, Møller, B, Dyzmann-sroka, A, Trojanowski, M, Góźdż, S, Mężyk, R, Grądalska-lampart, M, Radziszewska, Au, Didkowska, Ja, Wojciechowska, U, Błaszczyk, J, Kępska, K, Bielska-lasota, M, Kwiatkowska, K, Forjaz, G, Rego, Ra, Bastos, J, Silva, Ma, Antunes, L, Bento, Mj, Mayer-da-silva, A, Miranda, A, Coza, D, Todescu, Ai, Valkov, My, Adamcik, J, Safaei Diba, C, Primic-žakelj, M, Žagar, T, Stare, J, Almar, E, Mateos, A, Quirós, Jr, Bidaurrazaga, J, Larrañaga, N, Díaz García, Jm, Marcos, Ai, Marcos-gragera, R, Vilardell Gil, Ml, Molina, E, Sánchez, Mj, Franch Sureda, P, Ramos Montserrat, M, Chirlaque, Md, Navarro, C, Ardanaz, Ee, Moreno-iribas, Cc, Fernández-delgado, R, Peris-bonet, R, Galceran, J, Khan, S, Lambe, M, Camey, B, Bouchardy, C, Usel, M, Ess, Sm, Herrmann, C, Bulliard, Jl, Maspoli-conconi, M, Frick, H, Kuehni, Ce, Schindler, M, Bordoni, A, Spitale, A, Chiolero, A, Konzelmann, I, Dehler, Si, Matthes, Kl, Rashbass, J, Stiller, Ca, Fitzpatrick, D, Gavin, A, Bannon, F, Black, Rj, Brewster, Dh, Huws, Dw, White, C, Finan, P, Allemani, C, Bonaventure, A, Carreira, H, Coleman, Mp, Di Carlo, V, Harewood, R, Liu, K, Matz, M, Montel, L, Nikšić, M, Rachet, B, Sanz, N, Spika, D, Stephens, R, Peake, M, Chalker, E, Newman, L, Baker, D, Soeberg, Mj, Aitken, J, Scott, C, Stokes, Bc, Venn, A, Farrugia, H, Giles, Gg, Threlfall, T, Currow, D, You, H, Hendrix, J, Lewis, C., Matz, M., Coleman, M., Carreira, H., Salmerã³n, D., Chirlaque, M., Allemani, C., Bouzbid, S., Hamdi-chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S., El Mistiri, M., Bayo, S., Malle, B., Manraj, S., Sewpaul-sungkur, R., Fabowale, A., Ogunbiyi, O., Bradshaw, D., Somdyala, N., Stefan, D., Abdel-rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M., Laura, E., Espinola, S., Calabrano, G., Carballo Quintero, B., Fita, R., Garcilazo, D., Giacciani, P., Diumenjo, M., Laspada, W., Green, M., Lanza, M., Ibañez, S., Lima, C., Lobo De Oliveira, E., Daniel, C., Scandiuzzi, C., De Souza, P., Melo, C., Del Pino, K., Laporte, C., Curado, M., De Oliveira, J., Veneziano, C., Veneziano, D., Latorre, M., Tanaka, L., Azevedo E. Silva, G., Galaz, J., Moya, J., Herrmann, D., Vargas, S., Herrera, V., Uribe, C., Bravo, L., Arias-ortiz, N., Jurado, D., Yépez, M., Galán, Y., Torres, P., Martínez-reyes, F., Pérez-meza, M., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J., Torres-cintrón, C., Tortolero-luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A., Woods, R., Noonan, G., Turner, D., Kumar, E., Zhang, B., Mccrate, F., Ryan, S., Hannah, H., Dewar, R., Macintyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D., Mcclure, C., Vriends, K., Bertrand, C., Louchini, R., Robb, K., Stuart-panko, H., Demers, S., Wright, S., George, J., Shen, X., Brockhouse, J., O'Brien, D., Ward, K., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A., Vigneau, F., Mackinnon, J., Wohler, B., Bayakly, A., Clarke, C., Glaser, S., West, D., Hernandez, B., Johnson, C., Jozwik, D., Charlton, M., Lynch, C., Huang, B., Tucker, T., Deapen, D., Liu, L., Hsieh, M., Xc, W., Stern, K., Gershman, S., Knowlton, R., Alverson, J., Copeland, G., Rogers, D., Lemons, D., Williamson, L., Hood, M., Hosain, G., Rees, J., Pawlish, K., Stroup, A., Key, C., Wiggins, C., Kahn, A., Schymura, M., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S., Rubertone, J., Slack, S., Fulton, J., Rousseau, D., Janes, Ta:, S., Sm, Bolick, S., Hurley, D., Richards, J., Whiteside, M., Nogueira, L., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D., Keitheri Cheteri, M., Farley, S., Hudson, A., Borchers, R., Stephenson, L., Espinoza, J., Weir, H., Edwards, B., Wang, N., Yang, L., Chen, J., Song, G., Xp, G., Zhang, P., Hm, G., Zhao, D., Zhang, J., Zhu, F., Tang, J., Shen, Y., Wang, J., Ql, L., Yang, X., Dong, J., Li, W., Cheng, L., Huang, Q., Huang, S., Guo, G., Wei, K., Chen, W., Zeng, H., Demetriou, A., Pavlou, P., Mang, W., Ngan, K., Kataki, A., Krishnatreya, M., Jayalekshmi, P., Sebastian, P., Sapkota, S., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-boker, L., Silverman, B., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Bhoo-pathy, N., Tuvshingerel, S., Chimedsuren, O., Al Khater, A., Al-eid, H., Jung, K., Won, Y., Chiang, C., Lai, M., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S., Sriplung, H., Eser, S., Yakut, C., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A., Aleinikova, O., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A., Faivre, J., Guizard, A., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A., Daoulas, M., Clavel, J., Le Guyader-peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R., Kumar, V., Ólafsdóttir, E., Tryggvadóttir, L., Comber, H., Walsh, P., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M., Tisano, F., Fanetti, A., Maspero, S., Candela, G., Scuderi, T., Gentilini, M., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann-sroka, A., Trojanowski, M., Góźdż, S., Mężyk, R., Grądalska-lampart, M., Radziszewska, A., Didkowska, J., Wojciechowska, U., Błaszczyk, J., Kępska, K., Bielska-lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R., Bastos, J., Silva, M., Antunes, L., Bento, M., Mayer-da-silva, A., Miranda, A., Coza, D., Todescu, A., Valkov, M., Adamcik, J., Safaei Diba, C., Primic-žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J., Bidaurrazaga, J., Larrañaga, N., Díaz García, J., Marcos, A., Marcos-gragera, R., Vilardell Gil, M., Molina, E., Sánchez, M., Franch Sureda, P., Ramos Montserrat, M., Navarro, C., Ardanaz, E., Moreno-iribas, C., Fernández-delgado, R., Peris-bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S., Herrmann, C., Bulliard, J., Maspoli-conconi, M., Frick, H., Kuehni, C., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S., Matthes, K., Rashbass, J., Stiller, C., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R., Brewster, D., Huws, D., White, C., Finan, P., Bonaventure, A., Di Carlo, V., Harewood, R., Liu, K., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Chalker, E., Newman, L., Baker, D., Soeberg, M., Aitken, J., Scott, C., Stokes, B., Venn, A., Farrugia, H., Giles, G., Threlfall, T., Currow, D., You, H., Hendrix, J., and Lewis, C.

Subjects
0301 basic medicine, Gynecology, medicine.medical_specialty, business.industry, Published Erratum, Obstetrics and Gynecology, Library science, Settore MED/42 - Igiene Generale E Applicata, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, Editorial team, 030220 oncology & carcinogenesis, medicine, business, Stage at diagnosis
Abstract

Objective. Ovarian cancer comprises several histological groups with widely differing levels of survival. We aimed to explore international variation in survival for each group to help interpret international differences in survival from all ovarian cancers combined. We also examined differences in stage-specific survival. Methods. The CONCORD programme is the largest population-based study of global trends in cancer survival, including data from 60 countries for 695,932 women (aged 15–99 years) diagnosed with ovarian cancer during 1995–2009. We defined six histological groups: type I epithelial, type II epithelial, germ cell, sex cord-stromal, other specific non-epithelial and non-specific morphology, and estimated age-standardised 5-year net survival for each country by histological group. We also analysed data from67 cancer registries for 233,659 women diagnosed from 2001 to 2009, for whom information on stage at diagnosis was available. We estimated agestandardised 5-year net survival by stage at diagnosis (localised or advanced). Results. Survival fromtype I epithelial ovarian tumours for women diagnosed during 2005–09 ranged from40 to 70%. Survival from type II epithelial tumours was much lower (20–45%). Survival fromgermcell tumours was higher than that of type II epithelial tumours, but also varied widely between countries. Survival for sex-cord stromal tumours was higher than for the five other groups. Survival from localised tumours was much higher than for advanced disease (80% vs. 30%). Conclusions. There is wide variation in survival between histological groups, and stage at diagnosis remains an important factor in ovarian cancer survival. International comparisons of ovarian cancer survival should incorporate histology.

Published
2017

48. Inzidenz und Überleben bei Leukämien in Deutschland nach aktuellen standardisierten Kategorien

Author

Alice Nennecke, Klaus Kraywinkel, and Antje Wienecke

Subjects
Gynecology, medicine.medical_specialty, business.industry, Public Health, Environmental and Occupational Health, Medicine, business
Abstract

Hintergrund Leukamien umfassen eine Vielzahl unterschiedlicher Krebserkrankungen des blutbildenden Systems. Unbestandige Definitionen und Klassifikationen erschweren bevolkerungsbezogene Vergleiche und Aussagen zu zeitlichen Trends. 2010 wurde im Rahmen des europaischen HAEMACARE-Projekts eine aktuell fur Epidemiologie- und Public-Health-Zwecke nutzbare Gruppierung auf Basis der ICD-O-3 (Internationale Klassifikation der Krankheiten fur die Onkologie, 3. Revision) und der 2008 veroffentlichten WHO-Klassifikation konsentiert. Erstmals werden fur Deutschland nach diesem System Leukamieneuerkrankungen und -uberleben anhand von Krebsregisterdaten differenziert dargestellt.

Published
2013

49. Von regionalen Daten zu bundesweiten Aussagen

Author

Roland Stabenow, Jörg Haberland, Klaus Kraywinkel, Benjamin Barnes, Stefan Dahm, and Alice Nennecke

Subjects
Gynecology, medicine.medical_specialty, business.industry, Public Health, Environmental and Occupational Health, medicine, Age distribution, business, Infant newborn
Abstract

Trotz inzwischen erreichter Flachendeckung und deutlicher Verbesserung der Datenlage zur Epidemiologie von Krebserkrankungen in Deutschland werden bundesweite Ergebnisse zu Inzidenz, Uberleben und Pravalenz vom Zentrum fur Krebsregisterdaten (ZfKD) zurzeit geschatzt und nicht direkt aus allen vorliegenden Daten berechnet. Die hierzu verwendeten Verfahren beruhen dabei auf einer Schatzung der Vollzahligkeit der Erfassung von Neuerkrankungen bzw. auf einer Einschatzung der Datenqualitat von Follow-up-Daten. Die Vollzahligkeit der Erfassung wird dabei auf der Basis des M/I-Verfahrens geschatzt, welches von der Annahme eines in den Bundeslandern weitgehend konstanten Verhaltnisses von Mortalitat und Inzidenz einer Krebserkrankung bei gleichem Alter und Geschlecht ausgeht. Einschlusskriterien fur die Aufnahme in den Datenpool zur Berechnung bundesweiter Uberlebensraten sind ein DCO-Anteil unter 15 % und plausible Uberlebensraten fur Pankreaskrebs und primar metastasierten Lungenkrebs. Die fur das Jahr 2010 geschatzten ca. 477.300 jahrlichen Krebserkrankungen beruhten bereits auf 429.900 erfassten Fallen (90 %), 10 Bundeslander trugen zuletzt zur Ermittlung bundesweiter Uberlebensraten bei.

Published
2013

50. Worldwide comparison of survival from childhood leukaemia for 1995-2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries.

Author

CONCORD Working Group, Bouzbid, S., Hamdi-Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S.H., El Mistiri, M.M., Bayo, S., Malle, B., Manraj, S.S., Sewpaul-Sungkur, R., Ogunbiyi, O.J., Bradshaw, D., Somdyala, N., Stefan, D.C., Abdel-Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M.S., Laura, E.A., Espinola, S.B., Calabrano, G.H., Carballo Quintero, B., Fita, R., Garcilazo, D.A., Giacciani, P.L., Diumenjo, M.C., Laspada, W.D., Green, M.A., Lanza, M.F., Ibañez, S.G., Lima, C.A., de Oliveira, E.L., Daniel, C., Scandiuzzi, C., De Souza, P., Melo, C.D., Del Pino, K., Laporte, C., Curado, M.P., de Oliveira, J.C., Veneziano, C., Veneziano, D.B., Azevedo E Silva, G., Galaz, J.C., Moya, J.A., Herrmann, D.A., Vargas, S., Herrera, V.M., Uribe, C.J., Bravo, L.E., Arias-Ortiz, N.E., Jurado, D.M., Yépez, M.C., Galán, Y.H., Torres, P., Martínez-Reyes, F., Pérez-Meza, M.L., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J.G., Torres-Cintrón, C.R., Tortolero-Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A.J., Woods, R.R., Noonan, G., Turner, D., Kumar, E., Zhang, B., McCrate, F.R., Ryan, S., Hannah, H., Dewar, R., MacIntyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D.E., McClure, C., Vriends, K.A., Bertrand, C., Louchini, R., Robb, K.I., Stuart-Panko, H., Demers, S., Wright, S., George, J.T., Shen, X., Brockhouse, J.T., O'Brien, D.K., Ward, K.C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A.G., Vigneau, F., MacKinnon, J.A., Wohler, B., Bayakly, A.R., Clarke, C.A., Glaser, S.L., West, D., Green, M.D., Hernandez, B.Y., Johnson, C.J., Jozwik, D., Charlton, M.E., Lynch, C.F., Huang, B., Tucker, T.C., Deapen, D., Liu, L., Hsieh, M.C., Wu, X.C., Stern, K., Gershman, S.T., Knowlton, R.C., Alverson, J., Copeland, G.E., Rogers, D.B., Lemons, D., Williamson, L.L., Hood, M., Hosain, G.M., Rees, J.R., Pawlish, K.S., Stroup, A., Key, C., Wiggins, C., Kahn, A.R., Schymura, M.J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S.S., Rubertone, J.J., Slack, S.J., Fulton, J.P., Rousseau, D.L., Janes, T.A., Schwartz, S.M., Bolick, S.W., Hurley, D.M., Richards, J., Whiteside, M.A., Nogueira, L.M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D.G., Cheteri, M.K., Farley, S., Hudson, A.G., Borchers, R., Stephenson, L., Espinoza, J.R., Weir, H.K., Edwards, B.K., Wang, N., Yang, L., Chen, J.S., Song, G.H., Gu, X.P., Zhang, P., Ge, H.M., Zhao, D.L., Zhang, J.H., Zhu, F.D., Tang, J.G., Shen, Y., Wang, J., Li, Q.L., Yang, X.P., Dong, J., Li, W., Cheng, L.P., Chen, J.G., Huang, Q.H., Huang, S.Q., Guo, G.P., Wei, K., Chen, W.Q., Zeng, H., Demetriou, A.V., Pavlou, P., Mang, W.K., Ngan, K.C., Kataki, A.C., Krishnatreya, M., Jayalekshmi, P.A., Sebastian, P., Sapkota, S.D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-Boker, L., Silverman, B.G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., 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Won, Y.J., Chiang, C.J., Lai, M.S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S.L., Sriplung, H., Eser, S., Yakut, C.I., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A.A., Aleinikova, O.V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A.M., Faivre, J., Guizard, A.V., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A.S., Daoulas, M., Clavel, J., Le Guyader-Peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-Bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-Ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S.R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R.A., Kumar, V., Ólafsdóttir, E.J., Tryggvadóttir, L., Comber, H., Walsh, P.M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M.F., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M.M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M.L., Tisano, F., Fanetti, A.C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M.A., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A.P., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., 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Abstract

Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia. Cancer registries participating in CONCORD were asked to submit tumour registrations for all children aged 0-14 years who were diagnosed with leukaemia between Jan 1, 1995, and Dec 31, 2009, and followed up until Dec 31, 2009. Haematological malignancies were defined by morphology codes in the International Classification of Diseases for Oncology, third revision. We excluded data from registries from which the data were judged to be less reliable, or included only lymphomas, and data from countries in which data for fewer than ten children were available for analysis. We also excluded records because of a missing date of birth, diagnosis, or last known vital status. We estimated 5-year net survival (ie, the probability of surviving at least 5 years after diagnosis, after controlling for deaths from other causes [background mortality]) for children by calendar period of diagnosis (1995-99, 2000-04, and 2005-09), sex, and age at diagnosis (<1, 1-4, 5-9, and 10-14 years, inclusive) using appropriate life tables. We estimated age-standardised net survival for international comparison of survival trends for precursor-cell acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML). We analysed data from 89 828 children from 198 registries in 53 countries. During 1995-99, 5-year age-standardised net survival for all lymphoid leukaemias combined ranged from 10·6% (95% CI 3·1-18·2) in the Chinese registries to 86·8% (81·6-92·0) in Austria. International differences in 5-year survival for childhood leukaemia were still large as recently as 2005-09, when age-standardised survival for lymphoid leukaemias ranged from 52·4% (95% CI 42

Published
2017

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