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3. In vivo anti-psoriasis, anti-inflammatory activities and oral toxicity studies of aqueous extract from seeds of Ammi visnaga L

Author

Seddik Nadia, Naya Abdallah, Ez-zahir Abdeljaouad, Belghmi Khalid, Marnissi Farida, and Oudghiri Mounia

Subjects
Kidney, biology, medicine.diagnostic_test, business.industry, medicine.drug_class, Pharmacology, biology.organism_classification, medicine.disease, Anti-inflammatory, Acute toxicity, medicine.anatomical_structure, In vivo, Psoriasis, Toxicity, Medicine, Ammi visnaga, General Pharmacology, Toxicology and Pharmaceutics, business, Mean corpuscular volume
Abstract

Ammi visnaga L (A.V.) is used in the traditional medicine for the treatment of kidney stones, diabetes and vitiligo. An in vivo anti-psoriasis, anti-inflammatory activities and oral toxicity studies of aqueous extract from seeds of Ammi visnaga L. was investigated. In the acute toxicity, the extract was administered orally in a single dose to rats (0- 2000-5000 mg/kg) and in the sub-acute toxicity daily for 28 days (0-300-600-1000 mg/kg/day). The symptoms of toxicity and mortality have been recorded daily and during 14 days of recovery with an examination of liver, kidney, hematologic, biochemical and histological analysis at the end of treatment. The anti-inflammatory activity was evaluated by induction of oedema and the anti-psoriasis by induction of a psoriasiform-like skin phenotype by UV-B radiations. No mortality was observed after single gavages by a dose up to 5000 mg/kg and no signs of toxicity noted. Clinical and biochemical examination during 28 days of gavages at all doses showed no significant difference compared to control group, while a significant reduction in MCV (mean corpuscular volume) and P-LCR (platelet large cell ratio) (p

Published
2020

5. Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen

Author

Zaid, Younes, primary, Marhoume, Fatimazahra, additional, Senhaji, Nezha, additional, Kojok, Kevin, additional, Boufous, Hicham, additional, Naya, Abdallah, additional, Oudghiri, Mounia, additional, Darif, Youssef, additional, Habti, Norddine, additional, Zouine, Soukaina, additional, Mohamed, Fekhaoui, additional, Chait, Abderahmane, additional, and Bagri, Abdellah, additional

Published
2016
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6. An Update of Research Animal Models of Inflammatory Bowel Disease.

Author

Baydi Z, Limami Y, Khalki L, Zaid N, Naya A, Mtairag EM, Oudghiri M, and Zaid Y

Subjects
Animals, Mice, Disease Models, Animal, Inflammatory Bowel Diseases genetics, Inflammatory Bowel Diseases immunology, Inflammatory Bowel Diseases microbiology
Abstract

Inflammatory bowel disease (IBD) is a group of chronic disorders that includes two main disease forms, Crohn's disease, and ulcerative colitis. The understanding of the intestinal inflammation occurring in IBD has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation. The usefulness of this research tool in IBD arises from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been used to investigate the underlying mechanisms and develop potential therapeutic strategies. The results of preclinical efficacy studies often inform the progression of therapeutic strategies. This review describes the distinct feature and limitations of each murine IBD model and discusses the previous and current lessons from the IBD models., Competing Interests: The authors declare that the research was conducted in the absence of any competing interests., (Copyright © 2021 Zineb Baydi et al.)

Published
2021
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