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12 results on '"Nakano, Takuro"'

2. Proof of Gene Doping in a Mouse Model with a Human Erythropoietin Gene Transferred Using an Adenoviral Vector

Author

Sugasawa, Takehito, primary, Nakano, Takuro, additional, Fujita, Shin-ichiro, additional, Matsumoto, Yuki, additional, Ishihara, Genki, additional, Aoki, Kai, additional, Yanazawa, Koki, additional, Ono, Seiko, additional, Tamai, Shinsuke, additional, Manevich, Lev, additional, Ueda, Haruna, additional, Ishibashi, Noriyo, additional, Tamai, Kenshirou, additional, Kanki, Yasuharu, additional, Yoshida, Yasuko, additional, Watanabe, Koichi, additional, Takemasa, Tohru, additional, Kawakami, Yasushi, additional, and Takekoshi, Kazuhiro, additional

Published
2021
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4. Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice

Author

Aoki, Kai, primary, Suzuki, Takuji, additional, Hui, Fang, additional, Nakano, Takuro, additional, Yanazawa, Koki, additional, Yonamine, Masato, additional, Fujita, Shinichiro, additional, Sugasawa, Takehito, additional, Yoshida, Yasuko, additional, Omi, Naomi, additional, Kawakami, Yasushi, additional, and Takekoshi, Kazuhiro, additional

Published
2021
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6. A/G heterozygote of the A-3826G polymorphism in the UCP-1 gene has higher BMI than A/A and G/G homozygote in young Japanese males

Author

Nakano, Takuro, Shinka, Toshikatsu, Sei, Masako, Sato, Yoichi, Umeno, Mayumi, Sakamoto, Kozue, Nomura, Isoko, and Nakahori, Yutaka

Subjects
young male, obesity, UCP-1, Japanese, A-3826G polymorphism
Abstract

UCP-1 is suggested to have important roles for thermogenesis and energy expenditure. To elucidate whether the A-3826G polymorphism that is located in the 5’ flanking region of the UCP-1 gene has roles in healthy young people, the polymorphism was genotyped among 251 young Japanese men whose mean age is 22.7 years old. We analyzed relationship between the A-3826G polymorphism and body mass index (BMI) or six biochemical parameters, serum concentration of total cholesterol (TC), high density lipoprotein (HDL) cholesterol, triglyceride (TG), asparatate aminotransferase (AST), alanine aminotransferase (ALT), fasting plasma glucose. The genotype frequencies were observed at the frequencies of 24.3% for AA, 48.2% for AG and 27.5% for GG, respectively. When BMI and the biochemical parameters were compared by ANOVA among individuals with each genotype, the statistical difference was observed only for BMI (P=0.016). Bonferroni’s test demonstrated that the men with the AG genotype have higher BMI than those with the AA genotype (22.4±2.8 vs. 21.4±2.2)(P=0.04). The individuals with the AG genotype also showed trend to have higher BMI than those with the GG, although the difference was not statistically apparent (22.4±2.8 vs. 21.5±2.3) (P=0.07). Our results indicated that the young healthy Japanese men with the AG heterozygote showed higher BMI than those with other genotypes.

Published
2006

11. Expression analysis of a mouse orthologue of HSFY, a candidate for the azoospermic factor on the human Y chromosome

Author

Kinoshita, Keigo, primary, Shinka, Toshikatsu, additional, Sato, Youichi, additional, Kurahashi, Hiroki, additional, Kowa, Hiroe, additional, Chen, Gang, additional, Umeno, Mayumi, additional, Toida, Kazunori, additional, Kiyokage, Emi, additional, Nakano, Takuro, additional, Ito, Susumu, additional, and Nakahori, Yutaka, additional

Published
2006
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12. Association of estrogen receptor alpha gene polymorphisms and lifestyle factors with calcaneal quantitative ultrasound and osteoporosis in postmenopausal Vietnamese women.

Author

Tran Binh, Shinka, Toshikatsu, Nguyen Khan, Vu Thi Thu Hien, Nguyen Thi Lam, Le Bach Mai, Nakano, Takuro, Sei, Masako, Yamamoto, Shigeru, Nakamori, Masayo, and Nakahori, Yutaka

Subjects
SELECTIVE estrogen receptor modulators, MEDICAL imaging systems, OSTEOPOROSIS in women, GENETIC polymorphisms, LIFESTYLES, STEROID hormones, VIETNAMESE people
Abstract

Genetic and lifestyle factors are important in the pathogenesis of osteoporosis. We investigated the relationships of PvuII and XbaI polymorphisms of the estrogen receptor alpha (ER-α) gene, lifestyle factors with speed of sound at the calcaneus (calcaneal SOS) and osteoporosis in a population-based study of 140 healthy postmenopausal women. By an analysis of covariates, women with higher copies of P or X alleles had higher calcaneal SOS compared with others ( P=0.012, PP vs. pp; P=0.045, Xx vs. xx). Women with lower copies of px or higher copies of PX haplotypes had higher calcaneal SOS compared with others ( P=0.021, 0 px vs. 2 px; P=0.011, 1 PX vs. 0 PX). The px and PX haplotypes, age and years since menopause were found to be independent predictors of calcaneal SOS in multiple linear regression models. Using logistic regression, we found an increased osteoporosis risk with evidence for a px haplotype dose effect (OR=2.82, 95% CI=1.50–5.31, P=0.001) and for a PX haplotype dose effect (OR=0.42, 95% CI=0.19−0.93, P=0.033). An increased educational level was associated with a reduced risk of osteoporosis ( P=0.035 in the model with px, P=0.044 in the model with PX). In conclusion, the present study suggests that PvuII and XbaI polymorphims of the ER-α gene, age, years since menopause and educational level are associated with bone density, as assessed by calcaneal SOS, and osteoporosis in postmenopausal Vietnamese women. [ABSTRACT FROM AUTHOR]

Published
2006
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