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4. THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer

Author

Omatsu, Mayuki, Nakanishi, Yuki, Iwane, Kosuke, Aoyama, Naoki, Duran, Angeles, Muta, Yu, Martinez-Ordoñez, Anxo, Han, Qixiu, Agatsuma, Nobukazu, Mizukoshi, Kenta, Kawai, Munenori, Yamakawa, Go, Namikawa, Mio, Hamada, Kensuke, Fukunaga, Yuichi, Utsumi, Takahiro, Sono, Makoto, Masuda, Tomonori, Hata, Akitaka, Araki, Osamu, Nagao, Munemasa, Yoshikawa, Takaaki, Ogawa, Satoshi, Hiramatsu, Yukiko, Tsuda, Motoyuki, Maruno, Takahisa, Kogame, Toshiaki, Kasashima, Hiroaki, Kakiuchi, Nobuyuki, Nakagawa, Masahiro M., Kawada, Kenji, Yashiro, Masakazu, Maeda, Kiyoshi, Saito, Yasuyuki, Matozaki, Takashi, Fukuda, Akihisa, Kabashima, Kenji, Obama, Kazutaka, Ogawa, Seishi, Sheibani, Nader, Diaz-Meco, Maria T., Moscat, Jorge, and Seno, Hiroshi

Published
2023
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5. Evolutionary histories of breast cancer and related clones

Author

Nishimura, Tomomi, Kakiuchi, Nobuyuki, Yoshida, Kenichi, Sakurai, Takaki, Kataoka, Tatsuki R., Kondoh, Eiji, Chigusa, Yoshitsugu, Kawai, Masahiko, Sawada, Morio, Inoue, Takuya, Takeuchi, Yasuhide, Maeda, Hirona, Baba, Satoko, Shiozawa, Yusuke, Saiki, Ryunosuke, Nakagawa, Masahiro M., Nannya, Yasuhito, Ochi, Yotaro, Hirano, Tomonori, Nakagawa, Tomoe, Inagaki-Kawata, Yukiko, Aoki, Kosuke, Hirata, Masahiro, Nanki, Kosaku, Matano, Mami, Saito, Megumu, Suzuki, Eiji, Takada, Masahiro, Kawashima, Masahiro, Kawaguchi, Kosuke, Chiba, Kenichi, Shiraishi, Yuichi, Takita, Junko, Miyano, Satoru, Mandai, Masaki, Sato, Toshiro, Takeuchi, Kengo, Haga, Hironori, Toi, Masakazu, and Ogawa, Seishi

Published
2023
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6. Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms

Author

Nannya, Yasuhito, Tobiasson, Magnus, Sato, Shinya, Bernard, Elsa, Ohtake, Shigeki, Takeda, June, Creignou, Maria, Zhao, Lanying, Kusakabe, Manabu, Shibata, Yuhei, Nakamura, Nobuhiko, Watanabe, Mizuki, Hiramoto, Nobuhiro, Shiozawa, Yusuke, Shiraishi, Yuichi, Tanaka, Hiroko, Yoshida, Kenichi, Kakiuchi, Nobuyuki, Makishima, Hideki, Nakagawa, Masahiro, Usuki, Kensuke, Watanabe, Mitsumasa, Imada, Kazunori, Handa, Hiroshi, Taguchi, Masataka, Kiguchi, Toru, Ohyashiki, Kazuma, Ishikawa, Takayuki, Takaori-Kondo, Akifumi, Tsurumi, Hisashi, Kasahara, Senji, Chiba, Shigeru, Naoe, Tomoki, Miyano, Satoru, Papaemanuil, Elli, Miyazaki, Yasushi, Hellström-Lindberg, Eva, and Ogawa, Seishi

Published
2023
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7. Long-term Survival After Endoscopic Resection For Gastric Cancer: Real-world Evidence From a Multicenter Prospective Cohort

Author

Mashimo, Yumi, Ishigooka, Masahiro, Fukase, Kazutoshi, Mizuguchi, Yasuhiko, Suzuki, Haruhisa, Ono, Hiroyuki, Hirasawa, Toshiaki, Takeuchi, Yoji, Ishido, Kenji, Hoteya, Shu, Yano, Tomonori, Tanaka, Shinji, Toya, Yosuke, Nakagawa, Masahiro, Toyonaga, Takashi, Takemura, Kenichi, Hirasawa, Kingo, Matsuda, Mitsuru, Yamamoto, Hironori, Tsuji, Yosuke, Hashimoto, Satoru, Yuki, Maeda, Oyama, Tsuneo, Takenaka, Ryuta, Yamamoto, Yoshinobu, Naito, Yuji, Yamamoto, Katsumi, Kobayashi, Nozomu, Kawahara, Yoshiro, Hirano, Masaaki, Koizumi, Shigeto, Hori, Shinichiro, Tajika, Masahiro, Hikichi, Takuto, Yao, Kenshi, Yokoi, Chizu, Ohnita, Ken, Hisanaga, Yasuhiro, Sumiyoshi, Tetsuya, Kitamura, Shinji, Tanaka, Hisao, Shimoda, Ryo, Shimazu, Taichi, Takizawa, Kohei, Tanabe, Satoshi, Kondo, Hitoshi, Iishi, Hiroyasu, Ninomiya, Motoki, and Oda, Ichiro

Published
2023
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11. Nonrecurrence Rate of Underwater EMR for ≤20-mm Nonampullary Duodenal Adenomas: A Multicenter Prospective Study (D-UEMR Study)

Author

Kanzaki, Hiromitsu, Inoue, Shuntaro, Miyake, Muneaki, Ohmori, Masayasu, Takeuchi, Yoji, Tani, Yasuhiro, Harada, Nobuyuki, Agatsuma, Nobukazu, Okada, Keijirou, Ikenouchi, Maiko, Nakatani, Yasuki, Uenoyama, Yoshito, Yamashita, Yukitaka, Ishikawa, Shigenao, Inaba, Tomoki, Miyahara, Koji, Moritou, Yuki, Nakagawa, Masahiro, Kitae, Hiroaki, Ishida, Tsugitaka, Naito, Yuji, Nishio, Akiyoshi, Shimatani, Masaaki, Kato, Ryo, Taki, Shinya, Mandai, Koichiro, Sanada, Kasumi, Nakase, Kojiro, Nebiki, Hiroko, Saito, Shunsuke, Wakatsuki, Toshiyuki, Nishimura, Naoyuki, Yamasaki, Yasushi, Uedo, Noriya, Akamatsu, Takuji, Kagawa, Tomo, Higashi, Reiji, Dohi, Osamu, Furukawa, Masanori, Takahashi, Yu, Inoue, Takuya, Tanaka, Shouichi, Takenaka, Ryuta, Iguchi, Mikitaka, Kawamura, Takuji, Tsuzuki, Takao, Yamasaki, Tomoaki, Yamashina, Takeshi, Nasu, Junichiro, Mannami, Tomohiko, Yamauchi, Atsushi, Matsueda, Kazuhiro, Aizawa, Shigeyuki, Mitsuhashi, Toshiharu, and Okada, Hiroyuki

Published
2022
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12. Coverage characteristics of self-repelling random walks in mobile ad-hoc networks

Author

Kulathumani, Vinod, Nakagawa, Masahiro, and Arora, Anish

Subjects
Computer Science - Networking and Internet Architecture
Abstract

A self-repelling random walk of a token on a graph is one in which at each step, the token moves to a neighbor that has been visited least often (with ties broken randomly). The properties of self-repelling random walks have been analyzed for two dimensional lattices and these walks have been shown to exhibit a remarkable uniformity with which they visit nodes in a graph. In this paper, we extend this analysis to self-repelling random walks on mobile networks in which the underlying graph itself is temporally evolving. Using network simulations in ns-3, we characterize the number of times each node is visited from the start until all nodes have been visited at least once. We evaluate under different mobility models and on networks ranging from 100 to 1000 nodes. Our results show that until about 85% coverage, duplicate visits are very rare highlighting the efficiency with which a majority of nodes in the network can be visited. Even at 100% coverage, the exploration overhead (the ratio of number of steps to number of unique visited nodes) remains low and under 2. Our analysis shows that self-repelling random walks are effective, structure-free tools for data aggregation in mobile ad-hoc networks.

Published
2017

13. EZ-AG: Structure-free data aggregation in MANETs using push-assisted self-repelling random walks

Author

Kulathumani, Vinod, Nakagawa, Masahiro, and Arora, Anish

Subjects
Computer Science - Networking and Internet Architecture
Abstract

This paper describes EZ-AG, a structure-free protocol for duplicate insensitive data aggregation in MANETs. The key idea in EZ-AG is to introduce a token that performs a self-repelling random walk in the network and aggregates information from nodes when they are visited for the first time. A self-repelling random walk of a token on a graph is one in which at each step, the token moves to a neighbor that has been visited least often. While self-repelling random walks visit all nodes in the network much faster than plain random walks, they tend to slow down when most of the nodes are already visited. In this paper, we show that a single step push phase at each node can significantly speed up the aggregation and eliminate this slow down. By doing so, EZ-AG achieves aggregation in only O(N) time and messages. In terms of overhead, EZ-AG outperforms existing structure-free data aggregation by a factor of at least log(N) and achieves the lower bound for aggregation message overhead. We demonstrate the scalability and robustness of EZ-AG using ns-3 simulations in networks ranging from 100 to 4000 nodes under different mobility models and node speeds. We also describe a hierarchical extension for EZ-AG that can produce multi-resolution aggregates at each node using only O(NlogN) messages, which is a poly-logarithmic factor improvement over existing techniques.

Published
2017

14. A rapid increase in tropical species of grouper (Perciformes: Serranidae) in the temperate waters, the Goto Islands, Japan.

Author

Okuyama, Junichi, Nakagawa, Masahiro, and Taneda, Takeshi

Subjects
*OCEAN currents, *GROUPERS, *PERCIFORMES, *MARKET surveys, TSUSHIMA Current
Abstract

Global warming has resulted in rapid poleward shifts in the geographical distributions of many tropical fish species. This study conducted daily market surveys from 2008 to 2013 to investigate catch trends of seven commercially important grouper species in the temperate Goto Islands, Japan. Our results revealed that the catch numbers of tropical grouper species increased rapidly by an average of 5.9-fold (12.3-fold at maximum) within six years, whereas the temperate and subtropical species did not exhibit substantial changes. Based on the findings of several previous studies, the rapid increase in the number of tropical groupers in temperate waters was most likely caused by the successful settlement of larvae transported from tropical waters. Large-scale ocean currents may facilitate larval transport from tropical waters because the Goto Islands face the Tsushima Warm Current, which branches from the Kuroshio Current. Meanwhile, the transition processes of size distribution in tropical groupers suggest a possible hypothesis that adults migrating from tropical waters first settle in temperate waters and then enhance their populations by reproduction. Further studies are required to determine how tropical grouper species settle and how their populations increase in temperate waters. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Author

Makishima, Hideki, Saiki, Ryunosuke, Nannya, Yasuhito, Korotev, Sophia, Gurnari, Carmelo, Takeda, June, Momozawa, Yukihide, Best, Steve, Krishnamurthy, Pramila, Yoshizato, Tetsuichi, Atsuta, Yoshiko, Shiozawa, Yusuke, Iijima-Yamashita, Yuka, Yoshida, Kenichi, Shiraishi, Yuichi, Nagata, Yasunobu, Kakiuchi, Nobuyuki, Onizuka, Makoto, Chiba, Kenichi, Tanaka, Hiroko, Kon, Ayana, Ochi, Yotaro, Nakagawa, Masahiro M., Okuda, Rurika, Mori, Takuto, Yoda, Akinori, Itonaga, Hidehiro, Miyazaki, Yasushi, Sanada, Masashi, Ishikawa, Takayuki, Chiba, Shigeru, Tsurumi, Hisashi, Kasahara, Senji, Muller-Tidow, Carsten, Takaori-Kondo, Akifumi, Ohyashiki, Kazuma, Kiguchi, Toru, Matsuda, Fumihiko, Jansen, Joop H., Polprasert, Chantana, Blombery, Piers, Kamatani, Yoichiro, Miyano, Satoru, Malcovati, Luca, Haferlach, Torsten, Kubo, Michiaki, Cazzola, Mario, Kulasekararaj, Austin G., Godley, Lucy A., Maciejewski, Jaroslaw P., and Ogawa, Seishi

Published
2022
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18. Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis

Author

Saiki, Ryunosuke, Momozawa, Yukihide, Nannya, Yasuhito, Nakagawa, Masahiro M., Ochi, Yotaro, Yoshizato, Tetsuichi, Terao, Chikashi, Kuroda, Yutaka, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Niida, Atsushi, Imoto, Seiya, Matsuda, Koichi, Morisaki, Takayuki, and Murakami, Yoshinori

Subjects
Medical research, Medicine, Experimental, Hematopoiesis -- Research, Myeloproliferative disorders -- Genetic aspects -- Development and progression -- Risk factors, Single nucleotide polymorphisms -- Research, Cardiovascular diseases -- Genetic aspects -- Development and progression -- Risk factors, Cancer -- Genetic aspects -- Development and progression -- Risk factors, Copy number variations -- Research, Biological sciences, Health
Abstract

Clonal hematopoiesis (CH) in apparently healthy individuals is implicated in the development of hematological malignancies (HM) and cardiovascular diseases. Previous studies of CH analyzed either single-nucleotide variants and indels (SNVs/indels) or copy number alterations (CNAs), but not both. Here, using a combination of targeted sequencing of 23 CH-related genes and array-based CNA detection of blood-derived DNA, we have delineated the landscape of CH-related SNVs/indels and CNAs in 11,234 individuals without HM from the BioBank Japan cohort, including 672 individuals with subsequent HM development, and studied the effects of these somatic alterations on mortality from HM and cardiovascular disease, as well as on hematological and cardiovascular phenotypes. The total number of both types of CH-related lesions and their clone size positively correlated with blood count abnormalities and mortality from HM. CH-related SNVs/indels and CNAs exhibited statistically significant co-occurrence in the same individuals. In particular, co-occurrence of SNVs/indels and CNAs affecting DNMT3A, TET2, JAK2 and TP53 resulted in biallelic alterations of these genes and was associated with higher HM mortality. Co-occurrence of SNVs/indels and CNAs also modulated risks for cardiovascular mortality. These findings highlight the importance of detecting both SNVs/indels and CNAs in the evaluation of CH. Analysis of single-nucleotide variants and copy number alterations gives a more complete picture of clonal hematopoiesis and its impact on hematological malignancy and cardiovascular disease., Author(s): Ryunosuke Saiki [sup.1] , Yukihide Momozawa [sup.2] , Yasuhito Nannya [sup.1] , Masahiro M. Nakagawa [sup.1] [sup.3] , Yotaro Ochi [sup.1] , Tetsuichi Yoshizato [sup.1] , Chikashi Terao [sup.4] [...]

Published
2021
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20. Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia

Author

Ueno, Hiroo, Yoshida, Kenichi, Shiozawa, Yusuke, Nannya, Yasuhito, Iijima-Yamashita, Yuka, Kiyokawa, Nobutaka, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Isobe, Tomoya, Seki, Masafumi, Kimura, Shunsuke, Makishima, Hideki, Nakagawa, Masahiro M., Kakiuchi, Nobuyuki, Kataoka, Keisuke, Yoshizato, Tetsuichi, Nishijima, Dai, Deguchi, Takao, Ohki, Kentaro, Sato, Atsushi, Takahashi, Hiroyuki, Hashii, Yoshiko, Tokimasa, Sadao, Hara, Junichi, Kosaka, Yoshiyuki, Kato, Koji, Inukai, Takeshi, Takita, Junko, Imamura, Toshihiko, Miyano, Satoru, Manabe, Atsushi, Horibe, Keizo, Ogawa, Seishi, and Sanada, Masashi

Published
2020
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21. Census: Fast, scalable and robust data aggregation in MANETs

Author

Kulathumani, Vinod, Arora, Anish, Parker, Kenneth, Sridharan, Mukundan, and Nakagawa, Masahiro

Subjects
Computer Science - Networking and Internet Architecture
Abstract

This paper describes Census, a protocol for data aggregation and statistical counting in MANETs. Census operates by circulating a set of tokens in the network using biased random walks such that each node is visited by at least one token. The protocol is structure-free so as to avoid high messaging overhead for maintaining structure in the presence of node mobility. It biases the random walks of tokens so as to achieve fast cover time; the bias involves short albeit multi-hop gradients that guide the tokens towards hitherto unvisited nodes. Census thus achieves a cover time of O(N/k) and message overhead of O(Nlog(N)/k) where N is the number of nodes and k the number of tokens in the network. Notably, it enjoys scalability and robustness, which we demonstrate via simulations in networks ranging from 100 to 4000 nodes under different network densities and mobility models., Comment: 25 pages, technical report, index terms:random walk, MANET, statistical aggregation, gossip, local gradients

Published
2014

26. FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters

Author

Li, Mengjiao, primary, Nishimura, Tatsunori, additional, Takeuchi, Yasuto, additional, Hongu, Tsunaki, additional, Wang, Yuming, additional, Shiokawa, Daisuke, additional, Wang, Kang, additional, Hirose, Haruka, additional, Sasahara, Asako, additional, Yano, Masao, additional, Ishikawa, Satoko, additional, Inokuchi, Masafumi, additional, Ota, Tetsuo, additional, Tanabe, Masahiko, additional, Tada, Kei-ichiro, additional, Akiyama, Tetsu, additional, Cheng, Xi, additional, Liu, Chia-Chi, additional, Yamashita, Toshinari, additional, Sugano, Sumio, additional, Uchida, Yutaro, additional, Chiba, Tomoki, additional, Asahara, Hiroshi, additional, Nakagawa, Masahiro, additional, Sato, Shinya, additional, Miyagi, Yohei, additional, Shimamura, Teppei, additional, Nagai, Luis Augusto E., additional, Kanai, Akinori, additional, Katoh, Manami, additional, Nomura, Seitaro, additional, Nakato, Ryuichiro, additional, Suzuki, Yutaka, additional, Tojo, Arinobu, additional, Voon, Dominic C., additional, Ogawa, Seishi, additional, Okamoto, Koji, additional, Foukakis, Theodoros, additional, and Gotoh, Noriko, additional

Published
2023
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27. Lesion size, elevated morphology, and non or closed-type atrophy are predictive factors for gastric adenocarcinoma of the fundic gland type rather than oxyntic gland adenoma

Author

Iwamuro, Masaya, Kusumoto, Chiaki, Nakagawa, Masahiro, Matsueda, Kazuhiro, Kobayashi, Sayo, Yoshioka, Masao, Inaba, Tomoki, Toyokawa, Tatsuya, Sakaguchi, Chihiro, Tanaka, Shouichi, Tanaka, Takehiro, and Okada, Hiroyuki

Subjects
oxyntic gland adenoma, Gastric adenocarcinoma of the fundic gland type (GA-FG), Oncology, gastric neoplasms, submucosal invasion, Gastroenterology
Abstract

Background: An oxyntic gland neoplasm confined to the mucosal layer (T1a) is classified as an oxyntic gland adenoma, whereas that with submucosal invasion (T1b) is defined as gastric adenocarcinoma of the fundic gland type (GA-FG). Methods: To reveal the differences in clinical features between them, we retrospectively investigated 136 patients with 150 oxyntic gland adenoma and GA-FG lesions. Results: The univariate analysis revealed that the mean size (GA-FG vs. oxyntic gland adenoma, 7.7±5.4 vs. 5.5±3.1 mm), the prevalence of elevated morphology (79.1% vs. 51.8%), black pigmentation within the lesion (23.9% vs. 9.6%), and non or closed-type atrophy (81.2% vs. 65.1%) were different between the two groups. A multivariate logistic regression analysis revealed that ≥5 mm lesion size (odds ratio, 2.96; 95% confidence interval: 1.21–7.23), elevated morphology (odds ratio, 2.40; 95% confidence interval: 1.06–5.45), and no or closed-type atrophy (odds ratio, 2.49; 95% confidence interval: 1.07–5.80) were factors in distinguishing GA-FG from oxyntic gland adenoma. When oxyntic gland neoplasms with no or one feature were judged as oxyntic gland adenomas and those with two or three features were judged as GA-FG, the sensitivity and specificity were 85.1% and 43.4% for GA-FG, respectively. Conclusions: We identified three possible distinctive features of GA-FG compared to oxyntic gland adenoma: lesion size ≥5 mm, elevated morphology, and no or closed-type atrophy.

Published
2023

28. Competition of dual SF3B1mt clones in MDS-RS is associated with distinct RNA mis-splicing in hematopoietic stem cells

Author

Moura, Pedro Luis, Nannya, Yasuhito, Aliouat, Affaf, Hofman, Isabel Juliana, Mortera-Blanco, Teresa, Yoshizato, Tetsuichi, Saiki, Ryunosuke, Nakagawa, Masahiro M., Creignou, Maria, Björklund, Ann-Charlotte, Walldin, Gunilla, Barbosa, Indira, Jansson, Monika, Grasso, Francesca, Elvarsdottir, Edda M., Woll, Petter S., Jacobsen, Sten Eirik W., Ogawa, Seishi, and Hellström-Lindberg, Eva

Published
2024
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30. Molecular pathogenesis of disease progression in MLL-rearranged AML

Author

Kotani, Shinichi, Yoda, Akinori, Kon, Ayana, Kataoka, Keisuke, Ochi, Yotaro, Shiozawa, Yusuke, Hirsch, Cassandra, Takeda, June, Ueno, Hiroo, Yoshizato, Tetsuichi, Yoshida, Kenichi, Nakagawa, Masahiro M., Nannya, Yasuhito, Kakiuchi, Nobuyuki, Yamauchi, Takuji, Aoki, Kosuke, Shiraishi, Yuichi, Miyano, Satoru, Maeda, Takahiro, Maciejewski, Jaroslaw P., Takaori-Kondo, Akifumi, Ogawa, Seishi, and Makishima, Hideki

Published
2019
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31. Age-related remodelling of oesophageal epithelia by mutated cancer drivers

Author

Yokoyama, Akira, Kakiuchi, Nobuyuki, Yoshizato, Tetsuichi, Nannya, Yasuhito, Suzuki, Hiromichi, Takeuchi, Yasuhide, Shiozawa, Yusuke, Sato, Yusuke, Aoki, Kosuke, Kim, Soo Ki, Fujii, Yoichi, Yoshida, Kenichi, Kataoka, Keisuke, Nakagawa, Masahiro M., Inoue, Yoshikage, Hirano, Tomonori, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Sanada, Masashi, Nishikawa, Yoshitaka, Amanuma, Yusuke, Ohashi, Shinya, Aoyama, Ikuo, Horimatsu, Takahiro, Miyamoto, Shin’ichi, Tsunoda, Shigeru, Sakai, Yoshiharu, Narahara, Maiko, Brown, J. B., Sato, Yoshitaka, Sawada, Genta, Mimori, Koshi, Minamiguchi, Sachiko, Haga, Hironori, Seno, Hiroshi, Miyano, Satoru, Makishima, Hideki, Muto, Manabu, and Ogawa, Seishi

Published
2019
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33. P424: LANDSCAPE OF CHROMATIN ACCESSIBILITY IN ACUTE MYELOID LEUKEMIA

Author

Ochi, Yotaro, primary, Nannya, Yasuhito, additional, Kasahara, Senji, additional, Hiramoto, Nobuhiro, additional, Kanemura, Nobuhiro, additional, Sezaki, Nobuo, additional, Sakurada, Maki, additional, Iwasaki, Makoto, additional, Kanda, Junya, additional, Ueda, Yasunori, additional, Yoshihara, Satoshi, additional, Nakagawa, Masahiro, additional, Saiki, Ryunosuke, additional, Yoda, Akinori, additional, Okuda, Rurika, additional, Motomura, Masanori, additional, Shiraishi, Yuichi, additional, Ishikawa, Takayuki, additional, Miyano, Satoru, additional, Takaori, Akifumi, additional, and Ogawa, Seishi, additional

Published
2023
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34. P713: EXPLORING CLONAL COMPETITION THROUGH 12-YEAR FOLLOW-UP OF AN MDS-RS PATIENT WITH DUAL SF3B1 MUTATIONS

Author

Moura, Pedro, primary, Hofman, Isabel, additional, Nannya, Yasuhito, additional, Aliouat, Affaf, additional, Mortera-Blanco, Teresa, additional, Yoshizato, Tetsuichi, additional, Saiki, Ryunosuke, additional, Nakagawa, Masahiro, additional, Björklund, Ann-Charlotte, additional, Walldin, Gunilla, additional, Barbosa, Indira, additional, Jansson, Monika, additional, Grasso, Francesca, additional, Creignou, Maria, additional, Elvarsdottir, Edda, additional, Woll, Petter, additional, Eirik Jacobsen, Sten, additional, Ogawa, Seishi, additional, and Hellström Lindberg, Eva, additional

Published
2023
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35. Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation

Author

Yoshizato, Tetsuichi, Nannya, Yasuhito, Atsuta, Yoshiko, Shiozawa, Yusuke, Iijima-Yamashita, Yuka, Yoshida, Kenichi, Shiraishi, Yuichi, Suzuki, Hiromichi, Nagata, Yasunobu, Sato, Yusuke, Kakiuchi, Nobuyuki, Matsuo, Keitaro, Onizuka, Makoto, Kataoka, Keisuke, Chiba, Kenichi, Tanaka, Hiroko, Ueno, Hiroo, Nakagawa, Masahiro M., Przychodzen, Bartlomiej, Haferlach, Claudia, Kern, Wolfgang, Aoki, Kosuke, Itonaga, Hidehiro, Kanda, Yoshinobu, Sekeres, Mikkael A., Maciejewski, Jaroslaw P., Haferlach, Torsten, Miyazaki, Yasushi, Horibe, Keizo, Sanada, Masashi, Miyano, Satoru, Makishima, Hideki, and Ogawa, Seishi

Published
2017
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36. Is the eCura system useful for selecting patients who require radical surgery after noncurative endoscopic submucosal dissection for early gastric cancer? A comparative study

Author

Hatta, Waku, Gotoda, Takuji, Oyama, Tsuneo, Kawata, Noboru, Takahashi, Akiko, Yoshifuku, Yoshikazu, Hoteya, Shu, Nakagawa, Masahiro, Hirano, Masaaki, Esaki, Mitsuru, Matsuda, Mitsuru, Ohnita, Ken, Yamanouchi, Kohei, Yoshida, Motoyuki, Dohi, Osamu, Takada, Jun, Tanaka, Keiko, Yamada, Shinya, Tsuji, Tsuyotoshi, Ito, Hirotaka, Hayashi, Yoshiaki, Nakamura, Tomohiro, Nakaya, Naoki, and Shimosegawa, Tooru

Published
2018
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37. Abstract P5-13-04: Clonal evolution of mammary epithelial cells into breast cancers

Author

Nishimura, Tomomi, primary, Kakiuchi, Nobuyuki, additional, Yoshida, Kenichi, additional, Sakurai, Takaki, additional, Kataoka, Tatsuki R., additional, Kondoh, Eiji, additional, Chigusa, Yoshitsugu, additional, Kawai, Masahiko, additional, Sawada, Morio, additional, Inoue, Takuya, additional, Takeuchi, Yasuhide, additional, Maeda, Hirona, additional, Baba, Satoko, additional, Shiozawa, Yusuke, additional, Saiki, Ryunosuke, additional, Nakagawa, Masahiro M., additional, Nannya, Yasuhito, additional, Ochi, Yotaro, additional, Hirano, Tomonori, additional, Inagaki-Kawata, Yukiko, additional, Aoki, Kosuke, additional, Hirata, Masahiro, additional, Suzuki, Eiji, additional, Takada, Masahiro, additional, Kawashima, Masahiro, additional, Kawaguchi, Kosuke, additional, Chiba, Kenichi, additional, Shiraishi, Yuichi, additional, Takita, Junko, additional, Miyano, Satoru, additional, Mandai, Masaki, additional, Takeuchi, Kengo, additional, Haga, Hironori, additional, Toi, Masakazu, additional, and Ogawa, Seishi, additional

Published
2023
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38. Epigenetic Classification of Acute Myeloid Leukemia Revealed By Genome-Wide Chromatin Profiling

Author

Ochi, Yotaro, Nannya, Yasuhito, Liew-Littorin, Markus, Kasahara, Senji, Hiramoto, Nobuhiro, Kanemura, Nobuhiro, Sezaki, Nobuo, Sakurada, Maki, Iwasaki, Makoto, Kanda, Junya, Ueda, Yasunori, Yoshihara, Satoshi, Osterroos, Albin, Motomura, Masanori, Nakagawa, Masahiro Marshall, Saiki, Ryunosuke, Yoda, Akinori, Okuda, Rurika, Shiraishi, Yuichi, Ishikawa, Takayuki, Miyano, Satoru, Takaori-Kondo, Akifumi, Lehmann, Soren, Ogawa, Seishi, Ochi, Yotaro, Nannya, Yasuhito, Liew-Littorin, Markus, Kasahara, Senji, Hiramoto, Nobuhiro, Kanemura, Nobuhiro, Sezaki, Nobuo, Sakurada, Maki, Iwasaki, Makoto, Kanda, Junya, Ueda, Yasunori, Yoshihara, Satoshi, Osterroos, Albin, Motomura, Masanori, Nakagawa, Masahiro Marshall, Saiki, Ryunosuke, Yoda, Akinori, Okuda, Rurika, Shiraishi, Yuichi, Ishikawa, Takayuki, Miyano, Satoru, Takaori-Kondo, Akifumi, Lehmann, Soren, and Ogawa, Seishi

Published
2023
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39. Clinicopathological Characteristics of Superficial Barrett's Adenocarcinoma in a Japanese Population: A Retrospective, Multicenter Study

Author

Hamada, Kenta, Kanzaki, Hiromitsu, Miyahara, Koji, Nakagawa, Masahiro, Mouri, Hirokazu, Mizuno, Motowo, Takahashi, Sakuma, Hori, Shinichiro, Nasu, Junichiro, Tsuzuki, Takao, Miyaike, Jiro, Takenaka, Ryuta, Yamauchi, Kenji, Kobayashi, Sayo, Toyokawa, Tatsuya, Inoue, Masafumi, Nishimura, Mamoru, Matsubara, Minoru, Tomoda, Jun, Yamasaki, Yasushi, Tanaka, Takehiro, Shirakawa, Yasuhiro, Kawahara, Yoshiro, Fujiwara, Toshiyoshi, Okada, Hiroyuki, and Okayama Gut Study Group

Subjects
Barrett's adenocarcinoma, lesion, surgery, Barrett Esophagus, endoscopic resection, Esophageal Neoplasms, Japan, short -segment Barrett's esophagus, metachronous, Humans, Adenocarcinoma, Retrospective Studies, long -segment Barrett's esophagus
Abstract

Objective Although Barrett's adenocarcinoma (BA) remains a minor disease in Japan, its incidence has been gradually increasing. We analyzed the characteristics of BA in Japanese populations. Methods We retrospectively reviewed medical records and analyzed the clinicopathological differences between short-segment Barrett's esophagus (SSBE) and long-segment Barrett's esophagus (LSBE), as well as metastasis. Local recurrence and metachronous lesions were analyzed only in patients who underwent endoscopic resection (ER). Patients Consecutive patients who had pathological T1 BAs resected by ER or surgery from January 2003 Results A total of 168 patients were analyzed, including 139 with SSBE and 29 with LSBE. In total, 67% of the SSBE lesions and 32% of the LSBE lesions were located between 0 and 3 o'clock (p=0.0014). No patients who achieved pathological margin-free resection (pR0) and 17% of patients who did not achieve pR0 experienced local recurrence (p=0.0131). None of the patients without lymphovascular involvement, a poorly differentiated component, lesion size of >30 mm, and submucosal invasion of >500 mu m experienced metastasis. The 5-year cumulative incidence rate of metachronous BA after ER was 0% in patients with SSBE and 40% in patients with LSBE (p=0.0005). Conclusion Superficial BA was likely to be detected at the right anterior wall of SSBE in the Japanese population. The risk for metachronous BA after ER was high in Japanese patients with LSBE, as in Western patients.

Published
2022

42. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Author

Makishima, Hideki, primary, Saiki, Ryunosuke, additional, Nannya, Yasuhito, additional, Korotev, Sophia, additional, Gurnari, Carmelo, additional, Takeda, June, additional, Momozawa, Yukihide, additional, Best, Steve, additional, Krishnamurthy, Pramila, additional, Yoshizato, Tetsuichi, additional, Atsuta, Yoshiko, additional, Shiozawa, Yusuke, additional, Iijima-Yamashita, Yuka, additional, Yoshida, Kenichi, additional, Shiraishi, Yuichi, additional, Nagata, Yasunobu, additional, Kakiuchi, Nobuyuki, additional, Onizuka, Makoto, additional, Chiba, Kenichi, additional, Tanaka, Hiroko, additional, Kon, Ayana, additional, Ochi, Yotaro, additional, Nakagawa, Masahiro M., additional, Okuda, Rurika, additional, Mori, Takuto, additional, Yoda, Akinori, additional, Itonaga, Hidehiro, additional, Miyazaki, Yasushi, additional, Sanada, Masashi, additional, Ishikawa, Takayuki, additional, Chiba, Shigeru, additional, Tsurumi, Hisashi, additional, Kasahara, Senji, additional, Müller-Tidow, Carsten, additional, Takaori-Kondo, Akifumi, additional, Ohyashiki, Kazuma, additional, Kiguchi, Toru, additional, Matsuda, Fumihiko, additional, Jansen, Joop H., additional, Polprasert, Chantana, additional, Blombery, Piers, additional, Kamatani, Yoichiro, additional, Miyano, Satoru, additional, Malcovati, Luca, additional, Haferlach, Torsten, additional, Kubo, Michiaki, additional, Cazzola, Mario, additional, Kulasekararaj, Austin G., additional, Godley, Lucy A., additional, Maciejewski, Jaroslaw P., additional, and Ogawa, Seishi, additional

Published
2023
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43. Long-term Survival After Endoscopic Resection For Gastric Cancer: Real-world Evidence From a Multicenter Prospective Cohort

Author

Suzuki, Haruhisa, primary, Ono, Hiroyuki, additional, Hirasawa, Toshiaki, additional, Takeuchi, Yoji, additional, Ishido, Kenji, additional, Hoteya, Shu, additional, Yano, Tomonori, additional, Tanaka, Shinji, additional, Toya, Yosuke, additional, Nakagawa, Masahiro, additional, Toyonaga, Takashi, additional, Takemura, Kenichi, additional, Hirasawa, Kingo, additional, Matsuda, Mitsuru, additional, Yamamoto, Hironori, additional, Tsuji, Yosuke, additional, Hashimoto, Satoru, additional, Yuki, Maeda, additional, Oyama, Tsuneo, additional, Takenaka, Ryuta, additional, Yamamoto, Yoshinobu, additional, Naito, Yuji, additional, Yamamoto, Katsumi, additional, Kobayashi, Nozomu, additional, Kawahara, Yoshiro, additional, Hirano, Masaaki, additional, Koizumi, Shigeto, additional, Hori, Shinichiro, additional, Tajika, Masahiro, additional, Hikichi, Takuto, additional, Yao, Kenshi, additional, Yokoi, Chizu, additional, Ohnita, Ken, additional, Hisanaga, Yasuhiro, additional, Sumiyoshi, Tetsuya, additional, Kitamura, Shinji, additional, Tanaka, Hisao, additional, Shimoda, Ryo, additional, Shimazu, Taichi, additional, Takizawa, Kohei, additional, Tanabe, Satoshi, additional, Kondo, Hitoshi, additional, Iishi, Hiroyasu, additional, Ninomiya, Motoki, additional, Oda, Ichiro, additional, Mashimo, Yumi, additional, Ishigooka, Masahiro, additional, Fukase, Kazutoshi, additional, and Mizuguchi, Yasuhiko, additional

Published
2023
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44. Inhibition of dopamine receptor D1 signaling promotes human bile duct cancer progression via WNT signaling

Author

Yogo, Akitada, primary, Masui, Toshihiko, additional, Takaishi, Shigeo, additional, Masuo, Kenji, additional, Chen, Ru, additional, Kasai, Yosuke, additional, Nagai, Kazuyuki, additional, Anazawa, Takayuki, additional, Watanabe, Sadanori, additional, Sakamoto, Satoko, additional, Watanabe, Akira, additional, Inagaki, Ryosaku, additional, Nakagawa, Masahiro M., additional, Ogawa, Seishi, additional, Seno, Hiroshi, additional, Uemoto, Shinji, additional, and Hatano, Etsuro, additional

Published
2022
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45. Robot-Assisted Partial Nephrectomy for Renal Cell Carcinoma Complicated by Leriche Syndrome : A Case Report

Author

YOSHINAGA, Mitsuhiro, TANAKA, Ryo, FUKAE, Shota, KAWAMURA, Norihiko, NAKAGAWA, Masahiro, TSUTAHARA, Koichi, TANIGAWA, Go, TAKAO, Tetsuya, and YAMAGUCHI, Seiji

Subjects
Leriche syndrome, 494.9, Renal cell carcinoma
Abstract

A 71-year-old man was referred to our hospital for treatment of a 2 cm-sized right renal mass incidentally found by computed tomography (CT) and was diagnosed with right renal cell carcinoma cT1aN0M0. Contrast-enhanced CT revealed that the aorta was completely occluded below the inferior mesenteric artery origin, and Leriche syndrome was diagnosed. CT angiography showed several collateral arteries along the abdominal wall. A robot-assisted laparoscopic partial nephrectomy was performed to treat renal cell carcinoma. Preoperatively, we marked the collateral arteries using ultrasonography to avoid injury during trocar insertion. We did not observe any decrease in blood flow in the right leg during the operation. The pathological diagnosis was clear cell renal cell carcinoma. Leriche syndrome is a chronic occlusive disease involving the infrarenal aorta and the iliac arteries. Since lower limb blood flow is dependent on collateral circulation, it is important to avoid injuring the collateral arteries during surgery., 本論文の要旨は，第240回日本泌尿器科学会関西地方会にて発表した．

Published
2021

46. Cooperative Effects of SRSF2 and STAG2 mutations on Development of Myelodysplastic Syndrome and Its Related Disorders

Author

Mori, Takuto, primary, Ochi, Yotaro, additional, Kon, Ayana, additional, Yoshizato, Tetsuichi, additional, Koseki, Haruhiko, additional, Nakayama, Manabu, additional, Yoda, Akinori, additional, Nakagawa, Masahiro Marshall, additional, Takeda, June, additional, Saiki, Ryunosuke, additional, Okuda, Rurika, additional, Nagata, Yasunobu, additional, Yoshida, Kenichi, additional, Sanada, Masashi, additional, Makishima, Hideki, additional, Takaori-Kondo, Akifumi, additional, Maciejewski, Jaroslaw P., additional, Atsuta, Yoshiko, additional, Haferlach, Torsten, additional, Nannya, Yasuhito, additional, and Ogawa, Seishi, additional

Published
2022
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47. Germline Risks and Clinical Impacts of DDX41 Mutations in Myeloid Malignancies

Author

Makishima, Hideki, primary, Saiki, Ryunosuke, additional, Nannya, Yasuhito, additional, Korotev, Sophia C., additional, Gurnari, Carmelo, additional, Takeda, June, additional, Momozawa, Yukihide, additional, Best, Steve, additional, Krishnamurthy, Pramila, additional, Yoshizato, Tetsuichi, additional, Atsuta, Yoshiko, additional, Shiozawa, Yusuke, additional, Iijima-Yamashita, Yuka, additional, Yoshida, Kenichi, additional, Shiraishi, Yuichi, additional, Nagata, Yasunobu, additional, Kakiuchi, Nobuyuki, additional, Onizuka, Makoto, additional, Chiba, Kenichi, additional, Tanaka, Hiroko, additional, Kon, Ayana, additional, Ochi, Yotaro, additional, Nakagawa, Masahiro Marshall, additional, Okuda, Rurika, additional, Mori, Takuto, additional, Yoda, Akinori, additional, Itonaga, Hidehiro, additional, Miyazaki, Yasushi, additional, Sanada, Masashi, additional, Ishikawa, Takayuki, additional, Chiba, Shigeru, additional, Tsurumi, Hisashi, additional, Kasahara, Senji, additional, Müller-Tidow, Carsten, additional, Takaori-Kondo, Akifumi, additional, Ohyashiki, Kazuma, additional, Kiguchi, Toru, additional, Matsuda, Fumihiko, additional, Jansen, Joop H., additional, Polprasert, Chantana, additional, Blombery, Piers, additional, Kamatani, Yoichiro, additional, Miyano, Satoru, additional, Malcovati, Luca, additional, Haferlach, Torsten, additional, Kubo, Michiaki, additional, Cazzola, Mario, additional, Kulasekararaj, Austin, additional, Godley, Lucy A., additional, Maciejewski, Jaroslaw P., additional, and Ogawa, Seishi, additional

Published
2022
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48. Long-Term Clonal Inversion in an MDS-RS Case with Dual SF3B1 Mutations

Author

Moura, Pedro Luis, primary, Hofman, Isabel Juliana F, additional, Nannya, Yasuhito, additional, Aliouat, Affaf, additional, Mortera-Blanco, Teresa, additional, Yoshizato, Tetsuichi, additional, Saiki, Ryunosuke, additional, Nakagawa, Masahiro Marshall, additional, Björklund, Ann-Charlotte, additional, Walldin, Gunilla, additional, Barbosa, Indira, additional, Jansson, Monika, additional, Grasso, Francesca, additional, Creignou, Maria, additional, Elvarsdottir, Edda Maria, additional, Woll, Petter S, additional, Jacobsen, Sten Eirik Waelgaard, additional, Ogawa, Seishi, additional, and Hellström-Lindberg, Eva, additional

Published
2022
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49. Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method

Author

Nakagawa, Masahiro Marshall, primary, Inagaki, Ryosaku, additional, Kuroda, Yutaka, additional, Nannya, Yasuhito, additional, Zhao, Lanying, additional, Ochi, Yotaro, additional, Takeda, June, additional, Xingxing, Qi, additional, Yoda, Akinori, additional, Kon, Ayana, additional, Kakiuchi, Nobuyuki, additional, Makishima, Hideki, additional, Matsuda, Shuichi, additional, and Ogawa, Seishi, additional

Published
2022
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