Search

Your search keyword '"Nadal, Jennifer"' showing total 131 results
Start Over Author "Nadal, Jennifer" Search Limiters Full Text
131 results on '"Nadal, Jennifer"'

2. Copeptin, Natriuretic Peptides, and Cardiovascular Outcomes in Patients With CKD: The German Chronic Kidney Disease (GCKD) Study

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Schneider, Markus P., Schultheiss, Ulla T., Friedrich, Nele, and Nauck, Matthias

Published
2023
Full Text
View/download PDF

3. Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Kraska, Detlef, Reis, André, Ekici, Arif B., Becker, Susanne, Alberth-Schmidt, Ulrike, Marschall, Sabine, Schefler, Eugenia, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Schmidt-Ott, Kai, Zeier, Martin, Sommerer, Claudia, Aykac, Mehtap, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Müller-Krebs, Sandra, Schultheiss, Ulla T., Friedrich, Nele, Nauck, Matthias, Nußhag, Christian, Reiser, Jochen, and Hayek, Salim S.

Published
2023
Full Text
View/download PDF

4. Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort

Author

Winitzki, Doris, Zacharias, Helena U., Nadal, Jennifer, Baid-Agrawal, Seema, Schaeffner, Elke, Schmid, Matthias, Busch, Martin, Bergmann, Manuela M., Schultheiss, Ulla, Kotsis, Fruzsina, Stockmann, Helena, Meiselbach, Heike, Wolf, Gunter, Krane, Vera, Sommerer, Claudia, Eckardt, Kai-Uwe, Schneider, Markus P., Schlieper, Georg, Floege, Jürgen, and Saritas, Turgay

Published
2022
Full Text
View/download PDF

5. Long-term outcomes of patients with IgA nephropathy in the German CKD cohort.

Author

Stamellou, Eleni, Nadal, Jennifer, Hendry, Bruce, Mercer, Alex, Seikrit, Claudia, Bechtel-Walz, Wibke, Schmid, Matthias, Moeller, Marcus J, Schiffer, Mario, Eckardt, Kai-Uwe, Kramann, Rafael, Floege, Jürgen, and investigators, the GCKD study

Subjects
*MAJOR adverse cardiovascular events, *RENAL replacement therapy, *PROPORTIONAL hazards models, *IGA glomerulonephritis, *CHRONIC kidney failure
Abstract

Background The importance of albuminuria as opposed to proteinuria in predicting kidney outcomes in primary immunoglobulin A nephropathy (IgAN) is not well established. Methods From 2010 to 2012, 421 patients with biopsy-proven IgAN have been enrolled into the German Chronic Kidney Disease (GCKD) cohort, a prospective observational cohort study (N  = 5217). Adjudicated endpoints include a composite kidney endpoint (CKE) consisting of eGFR decline >40%, eGFR <15 ml/min/1.73 m2 and initiation of kidney replacement therapy; the individual components of the CKE; and combined major adverse cardiac events (MACE), including non-fatal myocardial infarction, non-fatal stroke and all-cause mortality. The associations between the incidence of CKE and baseline factors, including demographics, laboratory values and comorbidities were analysed using the Cox proportional hazards regression model. Results The mean age of IgAN patients at baseline was 51.6 years (± 13.6) and 67% were male. The patient-reported duration of disease at baseline was 5.9 ± 8.1 years. Baseline median urine albumin:creatinine ratio (UACR) was 0.4 g/g [interquartile range (IQR) 0.1–0.8] and mean eGFR was 52.5 ± 22.4 ml/min/1.73 m2. Over a follow-up of 6.5 years, 64 (15.2%) patients experienced a >40% eGFR decline, 3 (0.7%) reached eGFR <15 ml/min/1.73 m2, 53 (12.6%) initiated kidney replacement therapy and 28% of the patients experienced the CKE. Albuminuria, with reference to <0.1 g/g, was most associated with CKE. Hazard ratios (HRs) at UACRs of 0.1–0.6 g/g, 0.6–1.4 g/g, 1.4–2.2 g/g and >2.2 g/g were 2.03 [95% confidence interval (CI) 1.02–4.05], 3.8 (95% CI 1.92–7.5), 5.64 (95% CI 2.58–12.33) and 5.02 (95% CI 2.29–11-03), respectively. Regarding MACE, the presence of diabetes [HR 2.53 (95% CI 1.11–5.78)] was the most strongly associated factor, whereas UACR and eGFR did not show significant associations. Conclusion In the GCKD IgAN subcohort, more than every fourth patient experienced a CKE event within 6.5 years. Our findings support the use of albuminuria as a surrogate to assess the risk of poor kidney outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Schachtl-Riess, Johanna F., Kheirkhah, Azin, Grüneis, Rebecca, Di Maio, Silvia, Schoenherr, Sebastian, Streiter, Gertraud, Losso, Jamie Lee, Paulweber, Bernhard, Lamina, Claudia, and Coassin, Stefan

Published
2021
Full Text
View/download PDF

8. Long-term outcomes of adults with FSGS in the German Chronic Kidney Disease cohort.

Author

Stamellou, Eleni, Nadal, Jennifer, Hendry, Bruce, Mercer, Alex, Bechtel-Walz, Wibke, Schiffer, Mario, Eckardt, Kai-Uwe, Kramann, Rafael, Moeller, Marcus J, Floege, Jürgen, and investigators, GCKD study

Subjects
*MAJOR adverse cardiovascular events, *PROPORTIONAL hazards models, *DISEASE risk factors, *CHRONIC kidney failure, *RENAL replacement therapy
Abstract

Background Focal segmental glomerulosclerosis (FSGS) can lead to kidney failure in adults. This study examines the progression of FSGS in the German Chronic Kidney Disease (GCKD) cohort. Methods The GCKD study (N  = 5217), a prospective cohort, included 159 patients with biopsy-confirmed FSGS recruited from 2010 to 2012. Baseline was defined as the first study visit. Adjudicated endpoints included a composite kidney endpoint (CKE), including an estimated glomerular filtration rate (eGFR) decrease >40%, eGFR <15 ml/min/1.73 m2 or initiation of kidney replacement therapy and combined major adverse cardiovascular events (MACE), including non-fatal myocardial infarction or stroke and all-cause mortality. Associations between baseline demographics, laboratory data, comorbidity and CKE and MACE were analysed using the Cox proportional hazards regression model. Results The mean age at baseline was 52.1 ± 13.6 years, with a disease duration of 4.72 years (quartile 1: 1; quartile 3: 6) before joining the study. The median urinary albumin:creatinine ratio (UACR) at baseline was 0.7 g/g (IQR 0.1;1.8), while mean eGFR was 55.8 ± 23 ml/min/1.73 m2. Based on clinical and pathological features, 69 (43.4%) patients were categorized as primary FSGS, 55 (34.6%) as secondary FSGS and 35 (22%) as indeterminate. Over a follow-up of 6.5 years, 44 patients reached the composite kidney endpoint and 16 individuals had at least one MACE. UACR ≥0.7 g/g was strongly associated with both the composite kidney endpoint {hazard ratio [HR] 5.27 [95% confidence interval (CI) 2.4–11.5]} and MACE [HR 3.37 (95% CI 1.05–10.82)] compared with <0.7 g/g, whereas a higher eGFR at baseline (per 10 ml/min) was protective for both endpoints [HR 0.8 (95% CI 0.68–0.95) and HR 0.63 (95% CI 0.46–0.88), respectively]. Patients with secondary FSGS experienced a greater rate of eGFR decline than patients with primary FSGS. Conclusions Lower eGFR and higher albuminuria are key risk factors for kidney disease progression and cardiovascular events in patients with FSGS. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

9. Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus, Dienemann, Thomas, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Ganslandt, Thomas, Reis, André, Ekici, Arif B., Avendaño, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Zitzmann, Rita, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Schlieper, Georg, Saritas, Turgay, Ernst, Sabine, Beaujean, Nicole, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Woitke, Rebecca, Wolf, Gunter, Busch, Martin, Fuß, Rainer, Sitter, Thomas, Blank, Claudia, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Zacharias, Helena, Schmid, Matthias, Nadal, Jennifer, Fazzini, Federica, Lamina, Claudia, Schultheiss, Ulla T., and Steinbrenner, Inga

Published
2020
Full Text
View/download PDF

10. Copeptin, Natriuretic Peptides, and Cardiovascular Outcomes in Patients With CKD: The German Chronic Kidney Disease (GCKD) Study

Author

Schneider, Markus P., primary, Schmid, Matthias, additional, Nadal, Jennifer, additional, Krane, Vera, additional, Saritas, Turgay, additional, Busch, Martin, additional, Schultheiss, Ulla T., additional, Meiselbach, Heike, additional, Friedrich, Nele, additional, Nauck, Matthias, additional, Floege, Jürgen, additional, Kronenberg, Florian, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
Full Text
View/download PDF

11. No evidence to support the impact of migration background on treatment response rates and cancer survival: a retrospective matched-pair analysis in Germany

Author

Rüdiger, Roman, Geiser, Franziska, Ritter, Manuel, Brossart, Peter, Keyver-Paik, Mignon-Denise, Faridi, Andree, Vatter, Hartmut, Bootz, Friedrich, Landsberg, Jennifer, Kalff, Jörg C., Herrlinger, Ulrich, Kristiansen, Glen, Pietsch, Torsten, Aretz, Stefan, Thomas, Daniel, Radbruch, Lukas, Kramer, Franz-Josef, Strassburg, Christian P., Gonzalez-Carmona, Maria, Skowasch, Dirk, Essler, Markus, Schmid, Matthias, Nadal, Jennifer, Ernstmann, Nicole, Sharma, Amit, Funke, Benjamin, and Schmidt-Wolf, Ingo G. H.

Published
2021
Full Text
View/download PDF

12. Cardiovascular risk due to diabetes mellitus in patients with chronic kidney disease - Prospective data from the German Chronic Kidney Disease cohort

Author

Ruhe, Johannes, primary, Nadal, Jennifer, additional, Bärthlein, Barbara, additional, Meiselbach, Heike, additional, Schultheiss, Ulla T, additional, Kotsis, Fruzsina, additional, Stockmann, Helena, additional, Krane, Vera, additional, Sommerer, Claudia, additional, Löffler, Ivonne, additional, Saritas, Turgay, additional, Kielstein, Jan T, additional, Sitter, Thomas, additional, Schneider, Markus P, additional, Schmid, Matthias, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Wolf, Gunter, additional, and Busch, Martin, additional

Published
2023
Full Text
View/download PDF

13. Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

Author

Sommerer, Claudia, primary, Müller-Krebs, Sandra, additional, Nadal, Jennifer, additional, Schultheiss, Ulla T., additional, Friedrich, Nele, additional, Nauck, Matthias, additional, Schmid, Matthias, additional, Nußhag, Christian, additional, Reiser, Jochen, additional, Eckardt, Kai-Uwe, additional, Zeier, Martin, additional, Hayek, Salim S., additional, Meiselbach, Heike, additional, Schneider, Markus P., additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Kraska, Detlef, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Alberth-Schmidt, Ulrike, additional, Marschall, Sabine, additional, Schefler, Eugenia, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Saritas, Turgay, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Schmidt-Ott, Kai, additional, Sommerer, Claudia, additional, Aykac, Mehtap, additional, Wolf, Gunter, additional, Busch, Martin, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Wanner, Christoph, additional, Krane, Vera, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Kronenberg, Florian, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
Full Text
View/download PDF

16. Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study.

Author

Steinbrenner, Inga, Sekula, Peggy, Kotsis, Fruzsina, Cube, Maja von, Cheng, Yurong, Nadal, Jennifer, Schmid, Matthias, Schneider, Markus P, Krane, Vera, Nauck, Matthias, Eckardt, Kai-Uwe, Schultheiss, Ulla T, and investigators, the GCKD

Subjects
CHRONIC kidney failure, KIDNEY physiology, CHRONICALLY ill, RENAL fibrosis, OSTEOPONTIN, KIDNEY failure
Abstract

Background Osteopontin (OPN), synthesized in the thick ascending limb of Henle's loop and in the distal tubule, is involved in the pathogenesis of kidney fibrosis, a hallmark of kidney failure (KF). In a cohort of chronic kidney disease (CKD) patients, we evaluated OPN's association with kidney markers and KF. Methods OPN was measured from baseline serum samples of German Chronic Kidney Disease study participants. Cross-sectional regression models for estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) as well as Cox regression models for all-cause mortality and KF were evaluated to estimate the OPN effect. Additionally, the predictive ability of OPN and time-dependent population-attributable fraction were evaluated. Results Over a median follow-up of 6.5 years, 471 KF events and 629 deaths occurred among 4950 CKD patients. One-unit higher log(OPN) was associated with 5.5 mL/min/1.73 m2 lower eGFR [95% confidence interval (95% CI) –6.4 to –4.6] and 1% change in OPN with 0.7% higher UACR (estimated effect 0.7, 95% CI 0.6–0.8). Moreover, higher OPN levels were associated with a higher risk of KF [hazard ratio (HR) 1.4, 95% CI 1.2–1.7] and all-cause mortality (HR 1.5, 95% CI 1.3–1.8). After 6 years, 31% of the KF events could be attributed to higher OPN levels (95% CI 3%–56%). Conclusions In this study, higher OPN levels were associated with kidney function markers worsening and a higher risk for adverse outcomes. A larger proportion of KF could be attributed to higher OPN levels, warranting further research on OPN with regards to its role in CKD progression and possible treatment options. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

17. The Cardiovascular Literature-Based Risk Algorithm (CALIBRA): Predicting Cardiovascular Events in Patients With Non-Dialysis Dependent Chronic Kidney Disease

Author

Neri, Luca, primary, Lonati, Caterina, additional, Titapiccolo, Jasmine Ion, additional, Nadal, Jennifer, additional, Meiselbach, Heike, additional, Schmid, Matthias, additional, Baerthlein, Barbara, additional, Tschulena, Ulrich, additional, Schneider, Markus P., additional, Schultheiss, Ulla T., additional, Barbieri, Carlo, additional, Moore, Christoph, additional, Steppan, Sonia, additional, Eckardt, Kai-Uwe, additional, Stuard, Stefano, additional, and Bellocchio, Francesco, additional

Published
2022
Full Text
View/download PDF

18. Spatial and temporal immunoreaction of nestin, CD44, collagen IX and GFAP in human retinal Muller cells in the developing fetal eye

Author

Bulirsch, Louisa M., Loeffler, Karin U., Holz, Frank G., Koinzer, Stefan, Nadal, Jennifer, Muller, Annette M., Herwig-Carl, Martina C., Bulirsch, Louisa M., Loeffler, Karin U., Holz, Frank G., Koinzer, Stefan, Nadal, Jennifer, Muller, Annette M., and Herwig-Carl, Martina C.

Abstract

The purpose of this study was to investigate Muller cells during the fetal development of the human eye. Willer cells in eyes of 39 human fetuses (11-38 weeks of gestation, WOG) and 6 infants (5 died of abusive head trauma, AHT, aged 1-9 months) were immunohistochemically stained and investigated for spatial and temporal immunoreaction of nestin, CD44, collagen IX and GFAP, which are stem cell markers or markers of intermediate filaments, respectively, in one of the hitherto largest cohorts of fetal eyes. Willer cells could be detected immunohistochemically as early as 12 WOG by immunohistochemical staining with nestin. Nestin was more strongly expressed in Willer cells of the peripheral retina and a centroperipheral gradient of immunoreaction over time was observed. CD44 was predominantly expressed in fetal eyes of the late second and early third trimester between (23 and 27 WOG) and significantly stronger in the infant eyes. Collagen IX labeling in the central retina was significantly stronger than in more peripheral sectors and increased with fetal age. GFAP staining in Muller cells was seen in the eye of a fetus of 38 WOG who died postnatally and in the infant eyes with and without history of AHT. Additionally, GFAP staining was present in the astmcytes of fetal and infant eyes. All examined markers were expressed by Willer cells at different developmental stages highlighting the plasticity of Willer cells during the development of the human eye. GFAP should be cautiously used as a marker for AHT as it was also expressed in fetal astmcytes and Willer cells in eyes without history of AHT.

Published
2022

19. Validation of a Novel Predictive Algorithm for Kidney Failure in Patients Suffering from Chronic Kidney Disease: The Prognostic Reasoning System for Chronic Kidney Disease (PROGRES-CKD)

Author

Bellocchio, Francesco, primary, Lonati, Caterina, additional, Ion Titapiccolo, Jasmine, additional, Nadal, Jennifer, additional, Meiselbach, Heike, additional, Schmid, Matthias, additional, Baerthlein, Barbara, additional, Tschulena, Ulrich, additional, Schneider, Markus, additional, Schultheiss, Ulla T., additional, Barbieri, Carlo, additional, Moore, Christoph, additional, Steppan, Sonja, additional, Eckardt, Kai-Uwe, additional, Stuard, Stefano, additional, and Neri, Luca, additional

Published
2021
Full Text
View/download PDF

21. Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease

Author

Schachtl-Riess, Johanna F., primary, Kheirkhah, Azin, additional, Grüneis, Rebecca, additional, Di Maio, Silvia, additional, Schoenherr, Sebastian, additional, Streiter, Gertraud, additional, Losso, Jamie Lee, additional, Paulweber, Bernhard, additional, Eckardt, Kai-Uwe, additional, Köttgen, Anna, additional, Lamina, Claudia, additional, Kronenberg, Florian, additional, Coassin, Stefan, additional, Meiselbach, Heike, additional, Schneider, Markus P., additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Saritas, Turgay, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Busch, Martin, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Wanner, Christoph, additional, Krane, Vera, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, Gronwald, Wolfram, additional, Schmid, Matthias, additional, and Nadal, Jennifer, additional

Published
2021
Full Text
View/download PDF

22. FC 061OSTEOPONTIN AND ITS ASSOCIATION WITH ADVERSE EVENTS IN THE GERMAN CHRONIC KIDNEY DISEASE STUDY

Author

Steinbrenner, Inga, primary, Cheng, Yurong, additional, Nadal, Jennifer, additional, Schmid, Matthias, additional, Kotsis, Fruzsina Kinga, additional, Meiselbach, Heike, additional, Schneider, Markus, additional, Krane, Vera, additional, Nauck, Matthias, additional, Eckardt, Kai-Uwe, additional, Köttgen, Anna, additional, Sekula, Peggy, additional, and Schultheiß, Ulla T, additional

Published
2021
Full Text
View/download PDF

23. Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14 176 individuals

Author

Fazzini, Federica, Lamina, Claudia, Meiselbach, Heike, Schönherr, Sebastian, Forer, Lukas, Weissensteiner, Hansi, Pramstaller, Peter P., Eckardt, Kai-Uwe, Hicks, Andrew A., Kronenberg, Florian, GCKD Investigators, Raftopoulou, Athina, Schneider, Markus, Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Kraska, Detlef, Reis, André, Ekici, Arif B., Becker, Susanne, Koller, Adriana, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Fuchsberger, Christian, Reinhard, Ursula, Flöge, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Pattaro, Cristian, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Del Greco, Fabiola M., Raschenberger, Julia, Kollerits, Barbara, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Döttelmayer, Patricia, Fendt, Liane, and Fritz, Josef

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Mitochondrial DNA, DNA Copy Number Variations, chronic kidney disease, diabetes, metabolic syndrome, mitochondrial DNA copy number, 610 Medizin, Type 2 diabetes, 030204 cardiovascular system & hematology, Mitochondrion, DNA, Mitochondrial, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Internal Medicine, Humans, Medicine, Prospective Studies, Triglycerides, Aged, Metabolic Syndrome, ddc:610, diabetes, business.industry, Original Articles, Middle Aged, medicine.disease, Obesity, mitochondrial DNA copy number, Cross-Sectional Studies, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Original Article, Female, Waist Circumference, Metabolic syndrome, business, Body mass index, chronic kidney disease, Kidney disease
Abstract

Journal of internal medicine 290(1), 190-202 (2021). doi:10.1111/joim.13242, Published by Wiley-Blackwell, Oxford [u.a.]

Published
2021

24. Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease

Author

Fazzini, Federica, primary, Lamina, Claudia, additional, Raschenberger, Julia, additional, Schultheiss, Ulla T., additional, Kotsis, Fruzsina, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Forer, Lukas, additional, Steinbrenner, Inga, additional, Meiselbach, Heike, additional, Bärthlein, Barbara, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Köttgen, Anna, additional, Kronenberg, Florian, additional, Schneider, Markus, additional, Dienemann, Thomas, additional, Prokosch, Hans-Ulrich, additional, Beck, Andreas, additional, Ganslandt, Thomas, additional, Reis, André, additional, Ekici, Arif B., additional, Avendaño, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Zitzmann, Rita, additional, Weigel, Anke, additional, Walz, Gerd, additional, Schultheiß, Ulla T., additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Schlieper, Georg, additional, Saritas, Turgay, additional, Ernst, Sabine, additional, Beaujean, Nicole, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Woitke, Rebecca, additional, Wolf, Gunter, additional, Busch, Martin, additional, Fuß, Rainer, additional, Sitter, Thomas, additional, Blank, Claudia, additional, Krane, Vera, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Kollerits, Barbara, additional, Oefner, Peter, additional, Gronwald, Wolfram, additional, Zacharias, Helena, additional, Schmid, Matthias, additional, and Nadal, Jennifer, additional

Published
2020
Full Text
View/download PDF

25. P0782PROGNOSTIC IMPACT OF NECK CIRCUMFERENCE ON CARDIVASCULAR OUTCOMES AND MORTALITY IN PATIENTS WITH MODERATE CHRONIC KIDNEY DISEASE: AN ANALYSIS FROM THE GERMAN CHRONIC KIDNEY DISEASE (GCKD) STUDY

Author

Cejka, Vladimir, primary, Störk, Stefan, primary, Nadal, Jennifer, primary, Schultheiß, Ulla T, primary, Köttgen, Anna, primary, Sommerer, Claudia, primary, Sitter, Thomas, primary, Meiselbach, Heike, primary, Busch, Martin, primary, Schneider, Markus, primary, Saritas, Turgay, primary, Kotsis, Fruzsina Kinga, primary, Wanner, Christoph, primary, Eckardt, Kai-Uwe, primary, and Krane, Vera, primary

Published
2020
Full Text
View/download PDF

27. PCSK9 and Cardiovascular Disease in Individuals with Moderately Decreased Kidney Function

Author

Kheirkhah, Azin, Lamina, Claudia, Kollerits, Barbara, Schachtl-Riess, Johanna F., Schultheiss, Ulla T., Forer, Lukas, Sekula, Peggy, Kotsis, Fruzsina, Eckardt, Kai-Uwe, Kronenberg, Florian, Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, B?rthlein, Barbara, Beck, Andreas, Reis, Andr?, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, K?ttgen, Anna, Schulthei?, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, J?rgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, B?rner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Sch?nherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, and Nadal, Jennifer

Published
2022
Full Text
View/download PDF

28. Status of periodontal health in German patients suffering from chronic kidney disease - data from the GCKD study

Author

Dannewitz, Bettina, Sommerer, Claudia, Stölzel, Peggy, Baid‐Agrawal, Seema, Nadal, Jennifer, Bärthlein, Barbara, Wanner, Christoph, Eckardt, Kai‐Uwe, Zeier, Martin, Schlagenhauf, Ulrich, Krane, Vera, Jockel‐Schneider, Yvonne, and GCKD Study Investigators

Subjects
ddc:610
Abstract

Aim: To assess the prevalence and severity of periodontitis in patients with moderate chronic kidney disease (CKD) and comparing the results with the self‐reported periodontitis awareness of the study subjects. Material and methods: The periodontal status of 270 patients with moderate CKD randomly selected from a cohort of 5,217 subjects participating in the prospective observational German Chronic Kidney Disease (GCKD) project was analysed by recording bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL). Furthermore, the awareness of the study subjects of their periodontal conditions was evaluated by a self‐reported questionnaire. Results: 24.4% of the CKD study patients showed no or only mild signs of periodontal disease, 47.6% displayed moderate and 27% severe periodontitis. Questionnaire data revealed that 62.3% of the study subjects with severe periodontitis were not aware of the presence of the disease, 44.4% denied having received any systematic periodontal therapy so far, although 50% of them indicated to visit their dentist regularly for professional tooth cleanings. Conclusion: While the clinical study data confirm an increased prevalence of periodontitis in CKD patients, their self‐reported awareness of periodontitis was low.

Published
2019

29. Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease

Author

Fazzini, Federica, Lamina, Claudia, Eckardt, Kai-Uwe, Köttgen, Anna, Kronenberg, Florian, GCKD Investigators, Meiselbach, Heike, Schneider, Markus, Dienemann, Thomas, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Fendt, Liane, Beck, Andreas, Ganslandt, Thomas, Reis, André, Ekici, Arif B., Avendaño, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Zitzmann, Rita, Weigel, Anke, Schultheiss, Ulla T., Walz, Gerd, Schultheiß, Ulla, Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Flöge, Jürgen, Schlieper, Georg, Saritas, Turgay, Ernst, Sabine, Beaujean, Nicole, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Woitke, Rebecca, Hicks, Andrew A., Wolf, Gunter, Busch, Martin, Fuß, Rainer, Sitter, Thomas, Blank, Claudia, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Zacharias, Helena, Schmid, Matthias, and Nadal, Jennifer

Subjects
Male, DNA Copy Number Variations, Kaplan-Meier Estimate, Middle Aged, Infections, Prognosis, DNA, Mitochondrial, Mitochondria, Hospitalization, Oxidative Stress, Cardiovascular Diseases, Risk Factors, Cause of Death, Germany, Prevalence, Humans, Female, Prospective Studies, Renal Insufficiency, Chronic, Aged, Follow-Up Studies, Proportional Hazards Models
Abstract

Kidney international 96(2), 480-488 (2019). doi:10.1016/j.kint.2019.04.021, Published by Elsevier, New York, NY

Published
2019
Full Text
View/download PDF

30. Status of periodontal health in German patients suffering from chronic kidney disease - data from the GCKD study

Author

GCKD Study Investigators, Dannewitz, Bettina, Sommerer, Claudia, Stölzel, Peggy, Baid‐Agrawal, Seema, Nadal, Jennifer, Bärthlein, Barbara, Wanner, Christoph, Eckardt, Kai‐Uwe, Zeier, Martin, Schlagenhauf, Ulrich, Krane, Vera, Jockel‐Schneider, Yvonne, GCKD Study Investigators, Dannewitz, Bettina, Sommerer, Claudia, Stölzel, Peggy, Baid‐Agrawal, Seema, Nadal, Jennifer, Bärthlein, Barbara, Wanner, Christoph, Eckardt, Kai‐Uwe, Zeier, Martin, Schlagenhauf, Ulrich, Krane, Vera, and Jockel‐Schneider, Yvonne

Abstract

Aim: To assess the prevalence and severity of periodontitis in patients with moderate chronic kidney disease (CKD) and comparing the results with the self‐reported periodontitis awareness of the study subjects. Material and methods: The periodontal status of 270 patients with moderate CKD randomly selected from a cohort of 5,217 subjects participating in the prospective observational German Chronic Kidney Disease (GCKD) project was analysed by recording bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL). Furthermore, the awareness of the study subjects of their periodontal conditions was evaluated by a self‐reported questionnaire. Results: 24.4% of the CKD study patients showed no or only mild signs of periodontal disease, 47.6% displayed moderate and 27% severe periodontitis. Questionnaire data revealed that 62.3% of the study subjects with severe periodontitis were not aware of the presence of the disease, 44.4% denied having received any systematic periodontal therapy so far, although 50% of them indicated to visit their dentist regularly for professional tooth cleanings. Conclusion: While the clinical study data confirm an increased prevalence of periodontitis in CKD patients, their self‐reported awareness of periodontitis was low.

Published
2019

31. Blood pressure control in chronic kidney disease: A cross-sectional analysis from the German Chronic Kidney Disease (GCKD) study

Author

Schneider, Markus P., Hilgers, Karl F., Schmid, Matthias, Hübner, Silvia, Nadal, Jennifer, Seitz, David, Busch, Martin, Haller, Hermann, Köttgen, Anna, Kronenberg, Florian, Baid-Agrawal, Seema, Schlieper, Georg, Schultheiss, Ulla, Sitter, Thomas, Sommerer, Claudia, Titze, Stephanie, Meiselbach, Heike, Wanner, Christoph, and Eckardt, Kai-Uwe

Subjects
Medizinische Fakultät, ddc:610
Abstract

We assessed the prevalence, awareness, treatment and control of hypertension in patients with moderate chronic kidney disease (CKD) under nephrological care in Germany. In the German Chronic Kidney Disease (GCKD) study, 5217 patients under nephrology specialist care were enrolled from 2010 to 2012 in a prospective observational cohort study. Inclusion criteria were an estimated glomerular filtration rate (eGFR) of 30–60 mL/min/1.73 m2 or overt proteinuria in the presence of an eGFR>60 mL/min/1.73 m2. Office blood pressure was measured by trained study personnel in a standardized way and hypertension awareness and medication were assessed during standardized interviews. Blood pressure was considered as controlled if systolic < 140 and diastolic < 90 mmHg. In 5183 patients in whom measurements were available, mean blood pressure was 139.5 ± 20.4 / 79.3 ± 11.8 mmHg; 4985 (96.2%) of the patients were hypertensive. Awareness and treatment rates were > 90%. However, only 2456 (49.3%) of the hypertensive patients had controlled blood pressure. About half (51.0%) of the patients with uncontrolled blood pressure met criteria for resistant hypertension. Factors associated with better odds for controlled blood pressure in multivariate analyses included younger age, female sex, higher income, low or absent proteinuria, and use of certain classes of antihypertensive medication. We conclude that blood pressure control of CKD patients remains challenging even in the setting of nephrology specialist care, despite high rates of awareness and medication use.

Published
2018

32. Influence of factor XIII activity on post-operative transfusion in congenital cardiac surgery - A retrospective analysis

Author

Fahlbusch, Fabian B., Heinlein, Thomas, Rauh, Manfred, Dittrich, Sven, Cesnjevar, Robert, Moosmann, Julia, Nadal, Jennifer, Schmid, Matthias, Muench, Frank, Schroth, Michael, Rascher, Wolfgang, and Topf, Hans-Georg

Subjects
Platelets, Heart Defects, Congenital, Male, Cardiac Surgery, Adolescent, Cardiovascular Procedures, Physiology, lcsh:Medicine, Surgical and Invasive Medical Procedures, Postoperative Hemorrhage, Intensive Care Units, Pediatric, Pediatric Surgery, Diagnostic Medicine, Animal Cells, Risk Factors, Medizinische Fakultät, Medicine and Health Sciences, Humans, Blood Transfusion, ddc:610, Child, lcsh:Science, Blood Coagulation, Retrospective Studies, Cyanosis, Cardiopulmonary Bypass, Blood Cells, Factor XIII, Transfusion Medicine, Body Weight, lcsh:R, Infant, Newborn, Biology and Life Sciences, Infant, Hematology, Cell Biology, Clinical Laboratory Sciences, Body Fluids, Blood, Physiological Parameters, Chest Tubes, Child, Preschool, Drainage, Female, lcsh:Q, Anatomy, Cellular Types, Research Article
Abstract

Objectives Coagulation factor XIII (FXIII) plays a key role in fibrin clot stabilization—an essential process for wound healing following cardiothoracic surgery. However, FXIII deficiency as a risk for post-operative bleeding in pediatric cardiac surgery involving cardiopulmonary bypass (CPB) for congenital heart disease (CHD) is controversially discussed. Thus, as primary outcome measures, we analyzed the association of pre-operative FXIII activity and post-operative chest tube drainage (CTD) loss with transfusion requirements post-operatively. Secondary outcomes included the influence of cyanosis and sex on transfusion. Methods Our retrospective analysis (2009–2010) encompassed a single center series of 76 cardio-surgical cases with CPB (0–17 years, mean age 5.61 years) that were post-operatively admitted to our pediatric intensive care unit (PICU). The observational period was 48 hours after cardiac surgery. Blood cell counts and coagulation status, including FXIII activity were routinely performed pre- and post-operatively. The administered amount of blood products and volume expanders was recorded electronically, along with the amount of CTD loss. Uni- and multivariate logistic regression analysis was performed to calculate the associations (odds ratios) of variables with post-operative transfusion needs. Results FXIII activities remained stable following CPB surgery. There was no association of pre- and post-operative FXIII activities and transfusion of blood products or volume expanders in the first 48 hours after surgery. Similarly, FXIII showed no association with CTD loss. Cyanosis and female sex were associated with transfusion rates. Conclusions Although essentially involved in wound healing and clotting after surgery, FXIII activity does not serve as a valid predictor of post-operative transfusion need.

Published
2018

34. Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease

Author

Fazzini, Federica, primary, Lamina, Claudia, additional, Fendt, Liane, additional, Schultheiss, Ulla T., additional, Kotsis, Fruzsina, additional, Hicks, Andrew A., additional, Meiselbach, Heike, additional, Weissensteiner, Hansi, additional, Forer, Lukas, additional, Krane, Vera, additional, Eckardt, Kai-Uwe, additional, Köttgen, Anna, additional, Kronenberg, Florian, additional, Schneider, Markus, additional, Dienemann, Thomas, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Ganslandt, Thomas, additional, Reis, André, additional, Ekici, Arif B., additional, Avendaño, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Zitzmann, Rita, additional, Weigel, Anke, additional, Walz, Gerd, additional, Schultheiß, Ulla, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Schlieper, Georg, additional, Saritas, Turgay, additional, Ernst, Sabine, additional, Beaujean, Nicole, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Woitke, Rebecca, additional, Wolf, Gunter, additional, Busch, Martin, additional, Fuß, Rainer, additional, Sitter, Thomas, additional, Blank, Claudia, additional, Wanner, Christoph, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Schönherr, Sebastian, additional, Oefner, Peter, additional, Gronwald, Wolfram, additional, Zacharias, Helena, additional, Schmid, Matthias, additional, and Nadal, Jennifer, additional

Published
2019
Full Text
View/download PDF

35. FP338ASSOCIATION OF SERUM UROMODULIN WITH DEATH, CARDIOVASCULAR AND RENAL EVENTS: RESULTS FROM THE GERMAN CHRONIC KIDNEY DISEASE (GCKD) STUDY

Author

Steubl, Dominik, primary, Schneider, Markus, additional, Meiselbach, Heike, additional, Nadal, Jennifer, additional, Saritas, Turgay, additional, Krane, Vera, additional, Sommerer, Claudia, additional, Baid-Agrawal, Seema, additional, Köttgen, Anna, additional, Eckardt, Kai-Uwe, additional, and Scherberich, Jürgen, additional

Published
2019
Full Text
View/download PDF

36. Patterns of medication use and the burden of polypharmacy in patients with chronic kidney disease: the German Chronic Kidney Disease study

Author

Schmidt, Insa M, primary, Hübner, Silvia, additional, Nadal, Jennifer, additional, Titze, Stephanie, additional, Schmid, Matthias, additional, Bärthlein, Barbara, additional, Schlieper, Georg, additional, Dienemann, Thomas, additional, Schultheiss, Ulla T, additional, Meiselbach, Heike, additional, Köttgen, Anna, additional, Flöge, Jürgen, additional, Busch, Martin, additional, Kreutz, Reinhold, additional, Kielstein, Jan T, additional, and Eckardt, Kai-Uwe, additional

Published
2019
Full Text
View/download PDF

37. Epicardial fat, cardiovascular risk factors and calcifications in patients with chronic kidney disease

Author

Saritas, Turgay, primary, Reinartz, Sebastian Daniel, additional, Nadal, Jennifer, additional, Schmoee, Jonas, additional, Schmid, Matthias, additional, Marwan, Mohamed, additional, Achenbach, Stephan, additional, Störk, Stefan, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Floege, Jürgen, additional, Peter Schneider, Markus, additional, and Schlieper, Georg, additional

Published
2019
Full Text
View/download PDF

38. Self-Reported Medication Use and Urinary Drug Metabolites in the German Chronic Kidney Disease (GCKD) Study

Author

Kotsis, Fruzsina, Schultheiss, Ulla T., Wuttke, Matthias, Schlosser, Pascal, Mielke, Johanna, Becker, Michael S., Oefner, Peter J., Karoly, Edward D., Mohney, Robert P., Eckardt, Kai-Uwe, Sekula, Peggy, Köttgen, Anna, Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, and Nadal, Jennifer

Published
2021
Full Text
View/download PDF

39. Spectrum and dosing of urate-lowering drugs in a large cohort of chronic kidney disease patients and their effect on serum urate levels: a cross-sectional analysis from the German Chronic Kidney Disease study.

Author

Kielstein, Jan T, Heisterkamp, Markus, Jing, Jiaojiao, Nadal, Jennifer, Schmid, Matthias, Kronenberg, Florian, Busch, Martin, Sommerer, Claudia, Lorenzen, Johan M, Eckardt, Kai-Uwe, Köttgen, Anna, and Investigators, for the GCKD Study

Subjects
CHRONIC kidney failure, CHRONICALLY ill, CROSS-sectional method, EPIDERMAL growth factor receptors, GLOMERULAR filtration rate
Abstract

Background Despite a plethora of studies on the effect of urate-lowering therapy (ULT) in patients with chronic kidney disease (CKD), current guidelines on the treatment of hyperuricaemia and gout vary, especially concerning the need for dose adjustment of allopurinol, whose main metabolite is accumulating with declining renal function. Data on allopurinol dosing and its relationship to renal function, co-medication and sex and the resulting urate level in large cohorts are missing. Methods We studied a subgroup of 2378 patients of the German Chronic Kidney Disease (GCKD) study to determine prescription patterns of ULT among CKD patients under nephrological care and the relationship of ULT dose to urate levels. Prescription and dosing of ULT were manually abstracted from the patient's paper charts at the baseline visit, in which all currently used medications and their dosing were recorded. Results In this cohort, 39.6% were women, the mean estimated glomerular filtration rate (eGFR) was 51.3 ± 19.3 mL/min/1.73 m2 and the mean age was 59.0 ± 12.4 years. Of the 2378 examined patients, 666 (28.0%) received ULT. The dose of ULT was available for 572 patients. The main ULT agent was allopurinol (94.4%), followed by febuxostat (2.9%) and benzbromarone (2.6%). Of the 540 patients who used allopurinol with a reported daily dose, 480 had an eGFR <60 mL/min/1.73 m2 and 320 had an eGFR <45 mL/min/1.73 m2, 31.5% of the latter (n  = 101) received a dose >150 mg/day, the recommended maximal dose for this level of eGFR. The prescribed dose was not related to eGFR: the median eGFR for patients taking 100, 150 and 300 mg/day was 40 [interquartile range (IQR) 32–49], 43 (34–52) and 42 (35–54) mL/min/1.73 m2, respectively. Patients with lower doses of allopurinol had higher serum urate levels than patients with higher (than recommended) allopurinol doses. Sex, alcohol intake, eGFR, use of diuretics and treatment with allopurinol were independent determinants of serum urate levels in multivariate regression analysis. Conclusions The most frequently used drug to lower serum urate levels in this CKD cohort was allopurinol. Even in patients regularly seen by nephrologists, the dose of allopurinol is often not adjusted to the current eGFR. Patients with higher ULT doses achieved better control of their serum urate levels. Lowering of serum urate in CKD patients requires balancing potential adverse effects of allopurinol with suboptimal control of serum urate levels. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

40. Epicardial fat, cardiovascular risk factors and calcifications in patients with chronic kidney disease.

Author

Saritas, Turgay, Reinartz, Sebastian Daniel, Nadal, Jennifer, Schmoee, Jonas, Schmid, Matthias, Marwan, Mohamed, Achenbach, Stephan, Störk, Stefan, Wanner, Christoph, Eckardt, Kai-Uwe, Floege, Jürgen, Schneider, Markus Peter, and Schlieper, Georg

Subjects
CARDIOVASCULAR diseases risk factors, KIDNEY calcification, CHRONIC kidney failure, CHRONICALLY ill, CALCIFICATION, GLOMERULAR filtration rate
Abstract

Background Epicardial adipose tissue (EAT) exerts cardiopathogenic effects, but the independent association between EAT and cardiovascular (CV) calcification in patients with chronic kidney disease (CKD) remains controversial. We therefore assessed the association between EAT, CV risk factors and CV calcifications. Methods 257 patients with CKD Stage 3 and/or overt proteinuria underwent quantification of EAT, coronary artery calcification and aortic valve calcification by computed tomography. Framingham and American College of Cardiology and American Heart Association (ACC-AHA) 10-year CV event risk scores were calculated for each patient. Results Using multivariable regression analysis, higher EAT was significantly associated with the majority of investigated risk factors {higher age: odds ratio [OR] 1.05/year [95% confidence interval (CI) 1.02–1.08]; male sex: OR 4.03 [95% CI 2.22–7.31]; higher BMI: OR 1.28/kg/m2 [95% CI 1.20–1.37]; former smoking: OR 1.84 [95% CI 1.07–3.17]; lower high-density lipoprotein cholesterol: OR 0.98/mg/dL [95% CI 0.96–1.00] and lower estimated glomerular filtration rate: OR 0.98/mL/min/1.73 m2 [95% CI 0.97–0.99]; all P < 0.05} and was not associated with diabetes mellitus, hypertensive nephropathy, total cholesterol and albuminuria. EAT was positively associated with higher ACC-AHA and Framingham risk scores. EAT correlated with coronary artery calcification and aortic valve calcification [Spearman ρ = 0.388 (95% CI 0.287–0.532) and r rb = 0.409 (95% CI 0.310–0.556), respectively], but these correlations were dependent on CV risk factors. Conclusions The increase of EAT can be explained by individual CV risk factors and kidney function and correlates with 10-year risk for CV event scores, suggesting that EAT is a modifiable risk factor in patients with CKD. Although EAT correlates with CV calcifications, these relations depend on CV risk factors. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

41. Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study

Author

Müller, Philipp L., primary, Pfau, Maximilian, additional, Möller, Philipp T., additional, Nadal, Jennifer, additional, Schmid, Matthias, additional, Lindner, Moritz, additional, de Sisternes, Luis, additional, Stöhr, Heidi, additional, Weber, Bernhard H. F., additional, Neuhaus, Christine, additional, Herrmann, Philipp, additional, Schmitz-Valckenberg, Steffen, additional, Holz, Frank G., additional, and Fleckenstein, Monika, additional

Published
2018
Full Text
View/download PDF

42. Influence of factor XIII activity on post-operative transfusion in congenital cardiac surgery—A retrospective analysis

Author

Fahlbusch, Fabian B., primary, Heinlein, Thomas, additional, Rauh, Manfred, additional, Dittrich, Sven, additional, Cesnjevar, Robert, additional, Moosmann, Julia, additional, Nadal, Jennifer, additional, Schmid, Matthias, additional, Muench, Frank, additional, Schroth, Michael, additional, Rascher, Wolfgang, additional, and Topf, Hans-Georg, additional

Published
2018
Full Text
View/download PDF

43. Glycaemic control and antidiabetic therapy in patients with diabetes mellitus and chronic kidney disease – cross-sectional data from the German Chronic Kidney Disease (GCKD) cohort

Author

Busch, Martin, Nadal, Jennifer, Schlieper, Georg Rainer, Sommerer, Claudia, Krane, Vera, Hilge, Robert, Kielstein, Jan T., Kronenberg, Florian, Wanner, Christoph, Eckardt, Kai-Uwe, Wolf, Gunter, GCKD Study Investigators, Schmid, Matthias, Schlieper, Georg, Findeisen, Katharina, Arweiler, Elfriede, Ernst, Sabine, Unger, Mario, Floege, Jürgen, Schaeffner, Elke, Baid-Agrawal, Seema, Petzold, Kerstin, Schindler, Ralf, Paul, Katharina, Titze, Stephanie, Hilgers, KarlF., Hübner, Silvia, Avendano, Susanne, Becker-Grosspitsch, Dinah, Köttgen, Anna, Schultheiss, UllaT., Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Walz, Gerd, Lorenzen, Johan, Kielstein, JanT., Otto, Petra, Haller, Hermann, Föllinger, Claudia, Löschner, Tanja, Zeier, Martin, Dittrich, Lisett, Sitter, Thomas, Blank, Claudia, Fischereder, Michael, Schmiedeke, Daniel, Toncar, Sebastian, Cavitt, Daniela, Schönowsky, Karina, Franz, Stefan, Hausknecht, Birgit, Rittmeier, Marion, Weigel, Anke, Schultheiss, Ulla T., Prokosch, Hans-Ulrich, Bärthlein, Barbara, Haberländer, Kerstin, Beck, Andreas, Ganslandt, Thomas, Knispel, Sabine, Dressel, Thomas, Gefeller, Olaf, Malzer, Martina, Reis, André, Ekici, ArifB., Kollerits, Barbara, Weißensteiner, Hansi, Forer, Lukas, Schönherr, Sebastian, Oefner, Peter, and Gronwald, Wolfram

Subjects
Adult, Blood Glucose, Male, Nephrology, medicine.medical_specialty, medicine.medical_treatment, Statistics as Topic, Renal function, 030209 endocrinology & metabolism, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Medizinische Fakultät, Hemoglobin A1C, Germany, Internal medicine, Chronic kidney disease, Glycaemic control, medicine, Humans, Hypoglycemic Agents, Prospective Studies, 030212 general & internal medicine, ddc:610, Renal Insufficiency, Chronic, Prospective cohort study, Aged, Oral antidiabetic drugs, Glycated Hemoglobin, business.industry, Insulin, Middle Aged, medicine.disease, Metformin, Cross-Sectional Studies, Glycemic index, Glycemic Index, Insulin therapy, Female, business, Research Article, medicine.drug, Kidney disease
Abstract

BMC nephrology 17(1), 59 (2016). doi:10.1186/s12882-016-0273-z, Published by BioMed Central, London

Published
2016
Full Text
View/download PDF

44. Additional file 4: Table S2. of Glycaemic control and antidiabetic therapy in patients with diabetes mellitus and chronic kidney disease – cross-sectional data from the German Chronic Kidney Disease (GCKD) cohort

Author

Busch, Martin, Nadal, Jennifer, Schmid, Matthias, Paul, Katharina, Titze, Stephanie, Hübner, Silvia, Köttgen, Anna, Schultheiss, Ulla, Baid-Agrawal, Seema, Lorenzen, Johan, Schlieper, Georg, Sommerer, Claudia, Krane, Vera, Hilge, Robert, Kielstein, Jan, Kronenberg, Florian, Wanner, Christoph, Kai-Uwe Eckardt, and Wolf, Gunter

Abstract

Correlates of median HbA1C levels >7.0 % (53 mmol/mol) including the most frequently used antidiabetic therapies according to stepwise logistic regression analysis (final model). (DOCX 22 kb)

Published
2016
Full Text
View/download PDF

45. Additional file 2: Figure S2. of Glycaemic control and antidiabetic therapy in patients with diabetes mellitus and chronic kidney disease – cross-sectional data from the German Chronic Kidney Disease (GCKD) cohort

Author

Busch, Martin, Nadal, Jennifer, Schmid, Matthias, Paul, Katharina, Titze, Stephanie, Hübner, Silvia, Köttgen, Anna, Schultheiss, Ulla, Baid-Agrawal, Seema, Lorenzen, Johan, Schlieper, Georg, Sommerer, Claudia, Krane, Vera, Hilge, Robert, Kielstein, Jan, Kronenberg, Florian, Wanner, Christoph, Kai-Uwe Eckardt, and Wolf, Gunter

Subjects
urogenital system, urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract

Association between hemoglobin and estimated glomerular filtration rate (eGFR) in 1759 patients having diabetes mellitus and stage 3 chronic kidney disease and/or overt proteinuria (r = 0.247, p

Published
2016
Full Text
View/download PDF

46. Additional file 3: Table S1. of Glycaemic control and antidiabetic therapy in patients with diabetes mellitus and chronic kidney disease – cross-sectional data from the German Chronic Kidney Disease (GCKD) cohort

Author

Busch, Martin, Nadal, Jennifer, Schmid, Matthias, Paul, Katharina, Titze, Stephanie, Hübner, Silvia, Köttgen, Anna, Schultheiss, Ulla, Baid-Agrawal, Seema, Lorenzen, Johan, Schlieper, Georg, Sommerer, Claudia, Krane, Vera, Hilge, Robert, Kielstein, Jan, Kronenberg, Florian, Wanner, Christoph, Kai-Uwe Eckardt, and Wolf, Gunter

Abstract

Correlates of median HbA1C levels >7.0 % (53 mmol/mol) according to logistic regression analysis (entire model). (DOCX 24 kb)

Published
2016
Full Text
View/download PDF

47. Additional file 1: Figure S1. of Glycaemic control and antidiabetic therapy in patients with diabetes mellitus and chronic kidney disease – cross-sectional data from the German Chronic Kidney Disease (GCKD) cohort

Author

Busch, Martin, Nadal, Jennifer, Schmid, Matthias, Paul, Katharina, Titze, Stephanie, Hübner, Silvia, Köttgen, Anna, Schultheiss, Ulla, Baid-Agrawal, Seema, Lorenzen, Johan, Schlieper, Georg, Sommerer, Claudia, Krane, Vera, Hilge, Robert, Kielstein, Jan, Kronenberg, Florian, Wanner, Christoph, Kai-Uwe Eckardt, and Wolf, Gunter

Subjects
endocrine system diseases, urogenital system, nutritional and metabolic diseases
Abstract

Association between hemoglobin and hemoglobin A1C (HbA1C) values in 1775 patients having diabetes mellitus and stage 3 chronic kidney disease and/or overt proteinuria (r = 0.082, p

Published
2016
Full Text
View/download PDF

48. Additional file 5: Table S3. of Glycaemic control and antidiabetic therapy in patients with diabetes mellitus and chronic kidney disease – cross-sectional data from the German Chronic Kidney Disease (GCKD) cohort

Author

Busch, Martin, Nadal, Jennifer, Schmid, Matthias, Paul, Katharina, Titze, Stephanie, Hübner, Silvia, Köttgen, Anna, Schultheiss, Ulla, Baid-Agrawal, Seema, Lorenzen, Johan, Schlieper, Georg, Sommerer, Claudia, Krane, Vera, Hilge, Robert, Kielstein, Jan, Kronenberg, Florian, Wanner, Christoph, Kai-Uwe Eckardt, and Wolf, Gunter

Abstract

Correlates of median HbA1C levels >7.0 % (53 mmol/mol) including the most frequently used antidiabetic therapies according to logistic regression analysis (entire model). (DOCX 24 kb)

Published
2016
Full Text
View/download PDF

49. Correction: Blood pressure control in chronic kidney disease: A cross-sectional analysis from the German Chronic Kidney Disease (GCKD) study

Author

Schneider, Markus P., Hilgers, Karl F., Baid-Agrawal, Seema, Schlieper, Georg, Schultheiss, Ulla, Sitter, Thomas, Sommerer, Claudia, Titze, Stephanie, Meiselbach, Heike, Wanner, Christoph, Eckardt, Kai-Uwe, GCKD Study Investigators, Schmid, Matthias, Hübner, Silvia, Nadal, Jennifer, Seitz, David, Busch, Martin, Haller, Hermann, Köttgen, Anna, and Kronenberg, Florian

Subjects
Pharmacology, Multidisciplinary, Pharmaceutics, lcsh:R, lcsh:Medicine, Drugs, Blood Pressure, Vascular Medicine, Drug Therapy, Nephrology, Hypertension, Chronic Kidney Disease, Medicine and Health Sciences, lcsh:Q, lcsh:Science, Resistant Hypertension, Diuretics, Research Article, Antihypertensives
Abstract

We assessed the prevalence, awareness, treatment and control of hypertension in patients with moderate chronic kidney disease (CKD) under nephrological care in Germany. In the German Chronic Kidney Disease (GCKD) study, 5217 patients under nephrology specialist care were enrolled from 2010 to 2012 in a prospective observational cohort study. Inclusion criteria were an estimated glomerular filtration rate (eGFR) of 30–60 mL/min/1.73 m2 or overt proteinuria in the presence of an eGFR>60 mL/min/1.73 m2. Office blood pressure was measured by trained study personnel in a standardized way and hypertension awareness and medication were assessed during standardized interviews. Blood pressure was considered as controlled if systolic < 140 and diastolic < 90 mmHg. In 5183 patients in whom measurements were available, mean blood pressure was 139.5 ± 20.4 / 79.3 ± 11.8 mmHg; 4985 (96.2%) of the patients were hypertensive. Awareness and treatment rates were > 90%. However, only 2456 (49.3%) of the hypertensive patients had controlled blood pressure. About half (51.0%) of the patients with uncontrolled blood pressure met criteria for resistant hypertension. Factors associated with better odds for controlled blood pressure in multivariate analyses included younger age, female sex, higher income, low or absent proteinuria, and use of certain classes of antihypertensive medication. We conclude that blood pressure control of CKD patients remains challenging even in the setting of nephrology specialist care, despite high rates of awareness and medication use.

Published
2018

50. Combined Fundus Autofluorescence and Near Infrared Reflectance as Prognostic Biomarkers for Visual Acuity in Foveal-Sparing Geographic Atrophy

Author

Lindner, Moritz, primary, Nadal, Jennifer, additional, Mauschitz, Matthias M., additional, Lüning, Anna, additional, Czauderna, Joanna, additional, Pfau, Maximilian, additional, Schmitz-Valckenberg, Steffen, additional, Holz, Frank G., additional, Schmid, Matthias, additional, and Fleckenstein, Monika, additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results