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1. Toll-like receptors (PP-001)

Author

D. J. Weisdorf, C. Svanborg, Q. Wang, P. Ekpo, D. Kim, M. Park, X. Liang, H. J. Kwak, D. Spencer, N. Srisamut, P. Datta, L. Bulat-Kardum, H. D. Ochs, F. E. Sepulveda, L. Song, A. Kariyone, M. Ogasawara, J. Jang, A. Junpee, K. Agematsu, D. R. Stach-Machado, H. Kariya, Daniela Verthelyi, K. Itoh, K. Yamazaki, W. Cheng, K. Miyake, S. Rezania, Q. Zhang, H. O. Bianchi, Y. Takeda, S. M. Kim, C. M. Blum, S. Ohta, J. C. Lee, F. Liu, M. E. Abdalsalam, Y. Sher, J. Cho, N. Nilsen, S. Das, J. Munz, K. A. Fitzgerald, Y. Jung, S. Hellmig, J. Inoue, W. W. Agace, C. Knetter, S. Sasawatari, F. Willems, T. Tomita, S. Akira, C. A. Palha De Sousa, C. L. Zawislak, D. Cole, P. Thuss-Patience, H. Jarmer, T. Espevik, F. Shokri, Ihsan Gursel, H. Yang, J. Seo, C. Gfell, D. H. Kim, J. N. Smith, X. Shen, F. Skjeldal, O. Bakke, E. P. Sgroe, A. Lennon-Dumenil, T. Hayashi, S. Rasmussen, S. Hong, I. Chung, J. Conlon, L. Cabanie, S. Gretschel, Y. Zhang, Y. Sakurai, S. Amigorena, M. Hattori, A. Ta, J. Zhang, H. An, R. A. Kurt, M. A. Zacks, M. Shirakawa, J. S. Rush, N. Parvizzadeh, M. Chen, J. Y. Kang, S. Kim, M. L. Salem, C. Yang, S. Maschalidi, O. Kumpf, X. Cao, J. S. Miller, O. Naga, D. Kanistanon, J. Lee, B. R. Blazar, Y. Liu, V. Flamand, D. Wakita, L. Grajkowska, Özlem Aslan, T. Seya, R. Lindblom, P. Abrahão, C. Ghirelli, N. M. Rachmawati, H. Oshiumi, L. Lu, U. Rungpanich, K. Inaba, E. Moseman, T. Nishimura, F. Piehl, B. Manoury, B. Nøhr Nielsen, T. Sasazuki, C. Lin, J. A. Hamerman, R. Colisson, T. Nakahama, T. Funasaka, W. Bae, A. Hasebe, K. McMichael, B. C. Cole, Y. Suda, G. A. Obando-Pereda, E. K. Ryu, R. F. Ashman, A. G. D. Bean, A. Wang, B. Bohle, F. Golsaz Shirazi, K. Chakraborty, K. Tosh, T. Olsson, V. Bachanova, P. Lenert, C. J. Kirschning, N. Toyama-Sorimachi, M. Kimoto, S. Paessler, D. Yoo, S. J. Oh, C. Kitzmüller, M. Schmitz, D. Baltzis, K. Ono, A. J. Karpala, L. Hamann, M. Matsumoto, J. Lou, Z. Kato, J. Tak, N. Amirmozzafari, A. T. Egunsola, L. HjerrildZeuthen, Y. Tsai, B. Löbel, D. Wang, M. V. Zeid-Kilani, E. Lien, H. E. Park, H. Liu, A. Kimura, L. Chang, N. Rashidi, N. Kondo, C. Ouyang, J. Wang, H. Fischer, E. K. Persson, M. Yadav, P. Tanthuvanit, J. K. Smith, S. Taki, N. J. Nilsen, V. Younesi, R. Mitamura, H. Jähnisch, I. Chinen, J. Chen, T. Kimura, E. Quivy, M. A. Farrar, N. Abdelmagid, P. Wongprompitak, H. Y. Kim, A H Zarnani, B. Uleng, O. Leo, R. W. Wong, H. Rabbani, Gizem Tincer, S. Bolliger, W. Huang, T. Miethke, D. Rodionov, L. Heslop, N. Makiuchi, O. Moussa, Y. Lee, S. Tanaka, M. S. Lee, M. Hashimoto, K. Takatsu, L. Tussey, H. Kitamura, M. Diez, C. Wang, J. Lum, J. Dutz, M. Puig, G. Robert, Y. Nagai, K. Masuko, S. Liu, W. Chen, M. Arjmand, Z. Dembic, C. Scheibenbogen, H. Weng, T. Matsunaga, Y. Maru, S. Daum, M. Ikutani, Y. Tang, M. Mosallaei, S. Ye, H. Husebye, H. Nikzamir, S. Bauer, E. Yang, Ismail Simsek, Y. Deng, H. Frøkiær, H. Kao, G. Weiss, A. L. Poussard, G. E. Etokebe, R. R. Schumann, H. H. Mu, I. Choi, S. Deifl, K. Masuda, M. Montero-Diaz, T. Kishimoto, M. Yao, U. Kavita, E. Latz, N. E. Yun, H. Ohnishi, C. Leng, J. Knezevic, Q. Yuan, L. Katoozian, S. Koizumi, Y. Aoyagi, A. M. Crespo, S. Takao, A. P. Makrigiannis, R. Wehner, D. Bitchev, P. Chong, S. Nuchprayoon, H. S. Koh, J. W. Lowenthal, S. Chiou, S. Watanabe, R. Zhong, M. Yoshizaki, G. P. Garlet, H. Poo, H. Geng, T. Böldicke, D. Torres, J. Khoshnoodi, H. Chen, U. McKeever, S. Miranda-Hernandez, S. Mutschlechner, J. Goeken, S. Umlauf, H. Tochio, B. Weaver, S. Delbauve, M. Yousefi, J. R. Ribeiro dos Reis, K. Fukudome, K. Harnesk, N. K. Yee, G. Rivell, Seda Yerlikaya, E. Lüdeking, J. Y. Kim, N. Tsuneyoshi, A. Chou, H. Li, G. Liu, H. Tsukamoto, X. Liu, A. Hise, N. Li, P. Cohen, Fuat Cem Yagci, and E. Jaensson

Subjects
biology, Toll, Immunology, biology.protein, Immunology and Allergy, General Medicine, Receptor, Cell biology
Published
2010

2. Immunoendocrinology and metabolism (PP-013)

Author

S. V. Kaveri, L. Rokbani, V. Lazanovich, I. A. Tuzankina, H. Ida, M. Mnif, A. P. Godovalov, V. Rumjanek, L. S. Paiva, Y. Joe, J. I. Shilov, K. Masuko, F. Boussema, R. Borojevic, E. Quivy, S. Ben Salah, S. Shagarova, H. Chung, H. Nakashima, N. Shinomiya, F. L. Oliveira, M. Kinoshita, J. Sim, M. Nakashima, Y. Aoyagi, D. Rodriguez, D. A. Drometr, M. Salmi, S. Ketari, H. Goto, K. Aalto, D. Wakita, N. Ksouri, J. Kranich, F. Furukawa, C. C. Pazos-Moura, N. Kanazawa, M. Gidlund, D. Shin, E. Ramos Sanchez, Z. Aydi, S. Kim, F. Mnif, M. Abid, S. Koizumi, H. Pae, J. Chung, T. Nishimura, N. Makiuchi, H. Fourati, H. Sugino, V. de Mello-Coelho, S. Tanaka, O. Cherif, K. M. Maslowski, A. Navarrete, S. Dogadin, K. Yoshiura, C. R. Mackay, M. Matsunaka, S. Delignat, S. Shono, A. Cordeiro, B. Ben Dhaou, H. Masmoudi, H. Jeong, O. Raitakari, M. Maksimow, F. F. Bloise, J. D. Dimitrov, N. Charfi, F. Sierro, S. Jalkanen, H. Kitamura, A. Sato, A. Savchenko, E. V. Markelova, S. T. Grey, S. Seki, V. Manchuk, S. Dasgupta, Y. Habu, R. Mitamura, N. Rekik, S. Lacroix-Desmazes, and M. Zheng

Subjects
medicine.medical_specialty, Endocrinology, Chemistry, Internal medicine, Immunology, medicine, Immunology and Allergy, General Medicine, Metabolism
Published
2010

3. Multiplicity, instability, and SCF convergence problems in Hartree-Fock solutions

Author

N. Makiuchi, L. E. Dardenne, L. A. C. Malbouisson, and J. D. M. Vianna

Subjects
Chemistry, Iterative method, Hartree–Fock method, Ab initio, Condensed Matter Physics, Diatomic molecule, Instability, Atomic and Molecular Physics, and Optics, Stability conditions, Physics::Atomic and Molecular Clusters, Applied mathematics, Molecular orbital, Physics::Chemical Physics, Physical and Theoretical Chemistry, Multiplicity (chemistry), Atomic physics
Abstract

The authors present a study of the instability and convergence of Hartree-Fock (HF) ab initio solutions for the diatomic systems H{sub 2}, LiH, CH, C{sub 2}, and N{sub 2}. In the study, they consider real molecular orbitals (MOs) and analyze the classes of single-determinant functions associated to Hartree-Fock-Roothaan (HFR) and Hartree-Fock-Pople-Nesbet (HFPN) equations. To determine the multiple HF solutions, they used either an SCF iterative procedure with aufbau and non-aufbau ordering rules or the algebraic method (AM). Stability conditions were determined using TICS and ASDW stability matrices, derived from the maximum and minimum method of functions (MMF). They examined the relationship between pure SCF convergence criterion with the aufbau ordering rule, and the classification of the HF solution as an extremum point in its respective class of functions. The results show that (1) in a pure converged SCF calculation, with the aufbau ordering rule, the solutions are not necessarily classified as a minimum of the HF functional with respect to the TICS or ASDW classes of solutions, and (2) for all studied systems, they obtained local minimum points associated only with the aufbau rule and the solutions of lower energies.

Published
2000

4. Electron correlation in III-V semiconductors doped with transition metals

Author

N. Makiuchi, Adalberto Fazzio, Armando Corbani Ferraz, Sadao Isotani, Paulo Motisuke, and Jose David Mangueira Vianna

Abstract

Realizamos um estudo sistematico de impurezas de metal de transicao das series 3d, 4d e 5d em semicondutores iii-v atraves do modelo de aglomerados moleculares utilizando duas tecnicas de campo medio diferentes: espalhamento multiplo-xALFA e a aproximacao semiempirica indo. Efeito de muitos-eletrons foram introduzidos para a descricao do espectro de excitacao atraves de correlacoes de multipletos e interacao de configuracoes. Apresentamos um estudo comparativo entre os espectros obtidos a partir do calculo de interacao de configuracoes e o espectro experimental, onde observamos uma melhor concordancia entre o espectro experimental e os resultados obtidos a partir de bases mais completas. Observamos tambem, uma melhor concordancia entre o espectro experimental e os nossos resultados quando os orbitais com maior carater d apresentam-se fortemente localizados. Nossos resultados para a correcao de multipletos comparados com nossos resultados do calculo de interacao de configuracao nos mostra uma boa concordancia, quando o calculo de interacao de configuracoes e realizado apenas com os orbitais e e T IND.2 com forte carater d. No estudo envolvendo relaxacoes e distorcoes no sistema GAAS:V POT.2+, observamos um favorecimento ao estado fundamental de alto-spin, ANTPOT.4 T IND.1. A systematical study about 3d, 4d and 5d transition metal impurities in III-V semiconductors were realized through the molecular approach using two differents mean-field techniques: Multiple Scattering-X and the semiempirical approximation INDO. Many electron effects was introduced through the multiplets corrections and the configuration interaction calculation to the excitation spectrum description. A comparative study between configuration interaction and experimental spectra is presented, where we observed a good agreement between the experimental spectrum and the results achieved from more complete basis. We also discuss the agreement of our results and the experimental study, when the orbitals with higher d-character are strongly localized. Our multiplets correction results compared with our configuration interaction results show us a good concordance when the configuration interaction calculation is realized with only e and t2 strong d-character orbitals. In the study involving relaxations and distortions in GaAs:v2+ system, we observe a favouring to the high-spin 4t1 ground-state.

Published
1990

5. Dynamics of Liver Macrophage Subsets in a Novel Mouse Model of Non-Alcoholic Steatohepatitis Using C57BL/6 Mice.

Author

Makiuchi N, Takano S, Tada Y, Kasai K, Igarashi N, Kani K, Kato M, Goto K, Matsuura Y, Ichimura-Shimizu M, Furusawa Y, Tsuneyama K, and Nagai Y

Abstract

Macrophages are critical for the development of non-alcoholic steatohepatitis (NASH). Our previous findings in TSNO mouse livers showed that an iHFC (high-fat/cholesterol/cholate) diet induced liver fibrosis similar to human NASH and led to the accumulation of distinct subsets of macrophage: CD11c + /Ly6C - and CD11c - /Ly6C + cells. CD11c + /Ly6C - cells were associated with the promotion of advanced liver fibrosis in NASH. On the other hand, CD11c - /Ly6C + cells exhibited an anti-inflammatory effect and were involved in tissue remodeling processes. This study aimed to elucidate whether an iHFC diet with reduced cholic acid (iHFC#2 diet) induces NASH in C57BL/6 mice and examine the macrophage subsets accumulating in the liver. Histological and quantitative real-time PCR analyses revealed that the iHFC#2 diet promoted inflammation and fibrosis indicative of NASH in the livers of C57BL/6 mice. Cell numbers of Kupffer cells decreased and recruited macrophages were accumulated in the livers of iHFC#2 diet-fed C57BL/6 mice. Notably, the iHFC#2 diet resulted in the accumulation of three macrophage subsets in the livers of C57BL/6 mice: CD11c + /Ly6C - , CD11c - /Ly6C + , and CD11c + /Ly6C + cells. However, CD11c + /Ly6C + cells were not distinct populations in the iHFC-fed TSNO mice. Thus, differences in cholic acid content and mouse strain affect the macrophage subsets that accumulate in the liver.

Published
2023
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6. Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis.

Author

Tada Y, Kasai K, Makiuchi N, Igarashi N, Kani K, Takano S, Honda H, Yanagibashi T, Watanabe Y, Usui-Kawanishi F, Furusawa Y, Ichimura-Shimizu M, Tabuchi Y, Takatsu K, Tsuneyama K, and Nagai Y

Subjects
Animals, Mice, CD11c Antigen, Diet, High-Fat adverse effects, Disease Models, Animal, Fibrosis, Liver pathology, Liver Cirrhosis etiology, Liver Cirrhosis pathology, Mice, Inbred C57BL, Macrophages metabolism, Macrophages pathology, Non-alcoholic Fatty Liver Disease etiology, Non-alcoholic Fatty Liver Disease pathology
Abstract

Macrophages play critical roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). However, it is unclear which macrophage subsets are critically involved in the development of inflammation and fibrosis in NASH. In TSNO mice fed a high-fat/cholesterol/cholate-based diet, which exhibit advanced liver fibrosis that mimics human NASH, we found that Kupffer cells (KCs) were less abundant and recruited macrophages were more abundant, forming hepatic crown-like structures (hCLS) in the liver. The recruited macrophages comprised two subsets: CD11c + /Ly6C - and CD11c - /Ly6C + cells. CD11c + cells were present in a mesh-like pattern around the lipid droplets, constituting the hCLS. In addition, CD11c + cells colocalized with collagen fibers, suggesting that this subset of recruited macrophages might promote advanced liver fibrosis. In contrast, Ly6C + cells were present in doughnut-like inflammatory lesions, with a lipid droplet in the center. Finally, RNA sequence analysis indicates that CD11c + /Ly6C - cells promote liver fibrosis and hepatic stellate cell (HSC) activation, whereas CD11c - /Ly6C + cells are a macrophage subset that play an anti-inflammatory role and promote tissue repair in NASH. Taken together, our data revealed changes in liver macrophage subsets during the development of NASH and shed light on the roles of the recruited macrophages in the pathogenesis of advanced fibrosis in NASH.

Published
2022
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7. Synthesis and self-organization of fluorene-conjugated bisimidazolylporphyrin and its optical properties.

Author

Ogawa K, Makiuchi N, and Kobuke Y

Subjects
Chromatography, Gel, Imidazoles chemistry, Nonlinear Dynamics, Photons, Porphyrins chemistry, Proton Magnetic Resonance Spectroscopy, Spectrophotometry, Ultraviolet, Fluorine chemistry, Imidazoles chemical synthesis, Optical Phenomena, Porphyrins chemical synthesis
Abstract

A conjugated-bisimidazolylporphyrin bridged by bis(ethynylfluorene) was synthesized and organized into linear polymer through self-coordination having mean molecular weights, M(w) and M(n), of ~2.1 × 105 Da and ~1.6 × 105 Da, respectively. A large two-photon absorption cross section value of 3.4 × 105 GM (per dimer unit) was observed. This value was comparable to that of the previously reported self-assembled linear polymer consisting of butadiyne-bridged imidazolylporphyrins. The two-photon absorption properties could be controlled by tuning the wavelength and absorption intensity of the one-photon absorption.

Published
2012
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