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18. Androgen Deprivation Therapy Potentiates the Efficacy of Vascular Targeted Photodynamic Therapy of Prostate Cancer Xenografts

Author

Kim, Kwanghee, primary, Watson, Philip A., additional, Lebdai, Souhil, additional, Jebiwott, Sylvia, additional, Somma, Alexander J., additional, La Rosa, Stephen, additional, Mehta, Dipti, additional, Murray, Katie S., additional, Lilja, Hans, additional, Ulmert, David, additional, Monette, Sebastien, additional, Scherz, Avigdor, additional, and Coleman, Jonathan A., additional

Published
2018
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19. Systemic Antitumor Immunity by PD-1/PD-L1 Inhibition Is Potentiated by Vascular-Targeted Photodynamic Therapy of Primary Tumors

Author

O'Shaughnessy, Matthew J., primary, Murray, Katie S., additional, La Rosa, Stephen P., additional, Budhu, Sadna, additional, Merghoub, Taha, additional, Somma, Alexander, additional, Monette, Sebastien, additional, Kim, Kwanghee, additional, Corradi, Renato Beluco, additional, Scherz, Avigdor, additional, and Coleman, Jonathan A., additional

Published
2018
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21. TREATMENT EFFECTS OF WST11 VASCULAR TARGETED PHOTODYNAMIC THERAPY IN UROTHELIAL CELL CARCINOMA AND FEASIBILITY, SAFETY, AND LONG TERM OUTCOMES IN THE UPPER URINARY TRACT OF SWINE

Author

Murray, Katie S, Winter, Ashley G, Corradi, Renato Beluco, LaRosa, Stephen, Jebiwott, Sylvia, Somma, Alexander, Takaki, Haruyuki, Srimathveeravalli, Govindarajan, Lepherd, Michelle, Monette, Sebastien, Kim, Kwanghee, Scherz, Avigdor, and Coleman, Jonathan A

Subjects
Male, Carcinoma, Transitional Cell, Photosensitizing Agents, Swine, Mice, Nude, Antineoplastic Agents, Xenograft Model Antitumor Assays, Article, Mice, Random Allocation, Treatment Outcome, Photochemotherapy, Urinary Bladder Neoplasms, Cell Line, Tumor, Animals, Humans, Female, Bacteriochlorophylls
Abstract

Surgical management of upper tract urothelial carcinoma requires kidney and ureter removal, compromising renal function. Nonsurgical alternatives have potentially prohibitive safety concerns. We examined the feasibility and safety of ablation of the ureter and renal pelvis using endoluminal vascular targeted photodynamic therapy in a porcine model. We also report the efficacy of WST11 vascular targeted photodynamic therapy in a murine model.After receiving approval we performed a total of 28 endoluminal ablations in the ureters and renal pelvis of 18 swine. Intravenous infusion of WST11 (4 mg/kg) followed by 10-minute laser illumination was done via percutaneous access or a retrograde ureteroscopic approach. Animals were followed clinically with laboratory testing, imaging and histology, which were evaluated at several postablation time points. A murine xenograft was created with the 5637 human urothelial cell carcinoma line to determine sensitivity to this therapy.At 24 hours 50 mW/cm laser fluence produced superficial necrosis of the ureter. Deeper necrosis penetrating the muscularis propria or adventitia was produced by treatment with 200 mW/cm in the ureter and the renal pelvis. At 4 weeks superficial urothelium had regenerated over the treatment site. No symptomatic obstruction, clinically relevant hydronephrosis or abnormality of laboratory testing was noted up to 4 weeks. Of the mice 80% had no evidence of tumor 19 days after WST11 vascular targeted photodynamic therapy.Urothelial cell carcinoma appears to be sensitive to WST11 vascular targeted photodynamic therapy. The depth of WST11 vascular targeted photodynamic therapy treatment effects can be modulated in a dose dependent manner by titrating light intensity. Moreover, when applied to the porcine upper urinary tract, this treatment modality is feasible via antegrade and retrograde access.

Published
2016

22. Irreversible Electroporation for Prostate Cancer as Salvage Treatment Following Prior Radiation and Cryotherapy.

Author

Murray, Katie S., Akin, Oguz, and Coleman, Jonathan A.

Subjects
*PROSTATE cancer treatment, *ELECTROPORATION therapy, *SALVAGE therapy, *COLD therapy, *CANCER radiotherapy
Abstract

Salvage treatment options after localized primary treatment failure of prostate cancer are limited and associated with risk for serious complications. We report on the management details of a 57-year-old African American man treated with partial-gland ablation using irreversible electroporation following local recurrence after brachytherapy and prior salvage cryoablation. Therapeutic and functional outcomes were assessed by conventional means, including serum prostate-specific antigen values and prostate biopsy results. [ABSTRACT FROM AUTHOR]

Published
2017
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24. Can we predict the need for clean intermittent catheterization after orthotopic neobladder construction?

Author

Murray, Katie S., Arther, Andrew R., Zuk, Keegan P., Lee, Eugene K., Lopez-Corona, Ernesto, and Holzbeierlein, Jeffrey M.

Abstract

Introduction: We aimed to identify peri‑operative and pathologic characteristics that may predict the need for clean intermittent catheterization (CIC) following radical cystectomy (RC) with orthotopic neobladder (ONB) in order to improve patient counseling on choice of urinary diversion. Materials and Methods: Between July 2004 and February 2013, all patients who underwent RC with ONB were identified. Peri‑operative clinical and pathological features were evaluated and correlated with patients reported need for CIC. The independent T‑test was performed for continuous variables and Chi‑square test was performed for categorical variables. Multivariate forward stepwise logistic regression analysis was used to identify variables that correlated with need for CIC after ONB. Results: During the study period, 114 patients underwent RC with ONB creation. On univariate analysis, patients with higher body mass index, younger age, and non‑vaginal or non‑nerve‑sparing procedures were more likely to require catheterization for complete emptying. Multivariate analysis demonstrates that conservative surgery (nerve sparing in males or vaginal sparing in females) was associated with a significantly lower rate of requiring CIC (Odds Ratio [OR] 0.20, P < 0.01). Surprisingly, older age was also associated with a slightly lower, but statistically significant, rate of requiring CIC (OR 0.92, P < 0.01). Conclusions: When counseling patients regarding the different types of diversions after RC, the potential need for long‑term CIC after ONB must be discussed. The clinical factors that appear to increase the need for CIC include non‑conservative RC (non‑nerve sparing in males and non‑vaginal sparing in females) and, to a certain degree, younger age. [ABSTRACT FROM AUTHOR]

Published
2015
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27. Metastatic inflammatory myofibroblastic tumor of the bladder.

Author

Libby EK, Ellis LT, Weinstein S, Hammer RD, and Murray KS

Abstract

A 61-year-old male presented with gross hematuria and transurethral resection of bladder tumor revealed inflammatory myofibroblastic tumor (IMT). Due to extent of disease leading to ureteral obstruction and hydronephrosis, radical cystectomy (RC) with ileal conduit urinary diversion was performed. Five months after RC, the patient presented with decreased urine output. Exploratory laparotomy revealed mass in right colon and right hemicolectomy revealed metastatic IMT to the bowel and pericolonic fat. To our knowledge, this is the first report of primary IMT of the bladder metastasizing to other organs.

Published
2018
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