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2. Nuclear export of circular RNA

Author

Ngo, Linh H., Bert, Andrew G., Dredge, B. Kate, Williams, Tobias, Murphy, Vincent, Li, Wanqiu, Hamilton, William B., Carey, Kirstyn T., Toubia, John, Pillman, Katherine A., Liu, Dawei, Desogus, Jessica, Chao, Jeffrey A., Deans, Andrew J., Goodall, Gregory J., and Wickramasinghe, Vihandha O.

Published
2024
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4. Publisher Correction: Nuclear export of circular RNA

Author

Ngo, Linh H., Bert, Andrew G., Dredge, B. Kate, Williams, Tobias, Murphy, Vincent, Li, Wanqiu, Hamilton, William B., Carey, Kirstyn T., Toubia, John, Pillman, Katherine A., Liu, Dawei, Desogus, Jessica, Chao, Jeffrey A., Deans, Andrew J., Goodall, Gregory J., and Wickramasinghe, Vihandha O.

Published
2024
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7. Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal

Author

Hodson, Charlotte, primary, van Twest, Sylvie, additional, Dylewska, Malgorzata, additional, O’Rourke, Julienne J., additional, Tan, Winnie, additional, Murphy, Vincent J., additional, Walia, Mannu, additional, Abbouche, Lara, additional, Nieminuszczy, Jadwiga, additional, Dunn, Elyse, additional, Bythell-Douglas, Rohan, additional, Heierhorst, Jörg, additional, Niedzwiedz, Wojciech, additional, and Deans, Andrew J., additional

Published
2022
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9. Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability

Author

Hodson, Charlotte, primary, Low, Jason K. K., additional, van Twest, Sylvie, additional, Jones, Samuel E., additional, Swuec, Paolo, additional, Murphy, Vincent, additional, Tsukada, Kaima, additional, Fawkes, Matthew, additional, Bythell-Douglas, Rohan, additional, Davies, Adelina, additional, Holien, Jessica K., additional, O’Rourke, Julienne J., additional, Parker, Benjamin L., additional, Glaser, Astrid, additional, Parker, Michael W., additional, Mackay, Joel P., additional, Blackford, Andrew N., additional, Costa, Alessandro, additional, and Deans, Andrew J., additional

Published
2022
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13. Association of clinical severity with FANCB variant type in Fanconi anemia

Author

Jung, Moonjung, primary, Ramanagoudr-Bhojappa, Ramanagouda, primary, van Twest, Sylvie, primary, Rosti, Rasim Ozgur, primary, Murphy, Vincent, primary, Tan, Winnie, primary, Donovan, Frank X., primary, Lach, Francis P., primary, Kimble, Danielle C., primary, Jiang, Caroline S., primary, Vaughan, Roger, primary, Mehta, Parinda A., primary, Pierri, Filomena, primary, Dufour, Carlo, primary, Auerbach, Arleen D., primary, Deans, Andrew J., primary, Smogorzewska, Agata, primary, and Chandrasekharappa, Settara C., primary

Published
2020
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17. Retroviral superantigens and type 1 diabetes mellitus

Author

Murphy, Vincent J., Harrison, Leonard C., Rudert, William A., Luppi, Patrizia, Trucco, Massimo, Fierabracci, Alessandra, Biro, Paul Andrew, and Bottazzo, Gian Franco

Subjects
Type 1 diabetes -- Research, Retrovirus infections -- Genetic aspects, Genomes -- Research, Biological sciences
Abstract

Conrad et al performed a study about the etiological involvement of an infectious agent in type 1 diabetes mellitus. They described the isolation of an unknown endogenous HERV-K10-like retroviral genome, IDDMK(sub 1,2)22, associated with a murine mammary tumor virus whose envelope gene encoded a superantigen. They used the U3-R-poly(A) oligonucleotide primer to detect the retroviral genome. However, in other experiments simulating the experimental conditions employed by Conrad et al, the transcribed genome was not detected and were not RNA specific.

Published
1998

18. Bioconversion of 2,4-diamino-6-nitrotoluene to a novel metabolite under anoxic and aerobic conditions

Author

Gilcrease, Patrick C. and Murphy, Vincent G.

Subjects
Aromatic compounds, Pseudomonas fluorescens -- Research, Plant metabolites -- Research, Biological sciences
Abstract

The biodegradation of 2,4-diamino-6-nitrotoluene (2,4-DANT) by a Pseudomonas fluorescens species forms the metabolite 4-N-acetylamino-2-amino-6-nitrotoluene under anoxic and aerobic conditions. P. fluorescens initially reduces 2,4,6-trinitrotoluene to aminodinitrotoluenes and then to diaminonitrotoluenes under nitrate-limited conditions. The 2,4-DANT converts to the metabolite but 2,6-diamino-4-nitrotoluene is not degraded. The biodegradation is faster under anoxic conditions as compared to aerobic conditions.

Published
1995

21. LETTERS.

Author

Tabori, Peter, Burns, John, Stocker, Theo, and Murphy, Vincent

Subjects
SAFETY standards, YACHTING
Published
2024

27. Quasi-distributed fibre-optic chemical sensing using telecom fibre

Author

Murphy, Vincent James and MacCraith, Brian

Subjects
Physics, Detectors, Telecommunication fibre, Sensors, Sol-gels
Abstract

A novel sensing approach combining sol-gel technology and standard graded index telecommunications fibre is presented. The tip of telecommunication fibre is etched using hydrofluoric acid resulting in a parabolic shaped cavity characteristic of the refractive index profile of the fibre. This cavity is then filled with sol-gel-derived silica doped with an analyte-sensitive dye. This configuration is evaluated using both fluorescence and absorption-based indicators for sensing chemical species such as oxygen and ammonia. The compatibility of the immobilisation system on telecommunications fibre with semiconductor laser diode excitation makes this approach particularly suited to quasidistributed sensing. Preliminary results for multi-point pH sensing incorporating an 850nm Optical Time Domain Reflectometer and a near-infra-red dye are presented. The characterisation of a new family of materials known as organically modified silicates (Ormosils) is also carried out. Film thickness and temporal stability are monitored as a function of organic : inorganic precursor ratio while film microstructure is examined using FTIR spectroscopy.

Published
1997

28. Immunoglobulin G Subclass-Specific Responses against Plasmodium falciparum Merozoite Antigens Are Associated with Control of Parasitemia and Protection from Symptomatic Illness

Author

Stanisic, Danielle I., primary, Richards, Jack S., additional, McCallum, Fiona J., additional, Michon, Pascal, additional, King, Christopher L., additional, Schoepflin, Sonja, additional, Gilson, Paul R., additional, Murphy, Vincent J., additional, Anders, Robin F., additional, Mueller, Ivo, additional, and Beeson, James G., additional

Published
2009
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29. Structure of an IgNAR-AMA1 Complex: Targeting a Conserved Hydrophobic Cleft Broadens Malarial Strain Recognition

Author

Henderson, Kylie A., primary, Streltsov, Victor A., additional, Coley, Andrew M., additional, Dolezal, Olan, additional, Hudson, Peter J., additional, Batchelor, Adrian H., additional, Gupta, Aditi, additional, Bai, Tao, additional, Murphy, Vincent J., additional, Anders, Robin F., additional, Foley, Michael, additional, and Nuttall, Stewart D., additional

Published
2007
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32. The syntheses and structures of coordinatively unsaturated aryloxy-hydride complexes of molybdenum, Mo(PMe3)4(OAr)H: reversible C&z.sbnd;H bond activation and comparison with their tungsten analogues

Author

Hascall, Tony, Murphy, Vincent J., Janak, Kevin E., and Parkin, Gerard

Subjects
*MOLYBDENUM, *TUNGSTEN
Abstract

Mo(PMe3)6 reacts with ArOH (Ar=2,4,6-C6H2Me3, 2,6-C6H3Pri2) to give coordinatively unsaturated aryloxy-hydride derivatives Mo(PMe3)4(OAr)H. The formation of Mo(PMe3)4(OAr)H is in marked contrast to the cyclometalated products of C&z.sbnd;H bond activation that are obtained for the corresponding tungsten system. Deuterium labeling and magnetization transfer studies, however, demonstrate that the coordinatively unsaturated molybdenum complexes Mo(PMe3)4(OAr)H are in fact kinetically capable of intramolecular oxidative addition of a C&z.sbnd;H bond of the ortho substituents to yield cyclometalated derivatives that are thermodynamically unstable with respect to the aryloxy-hydride derivatives. [Copyright &y& Elsevier]

Published
2002
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33. Immunoglobulin G Subclass-Specific Responses against Plasmodium falciparumMerozoite Antigens Are Associated with Control of Parasitemia and Protection from Symptomatic Illness

Author

Stanisic, Danielle I., Richards, Jack S., McCallum, Fiona J., Michon, Pascal, King, Christopher L., Schoepflin, Sonja, Gilson, Paul R., Murphy, Vincent J., Anders, Robin F., Mueller, Ivo, and Beeson, James G.

Abstract

ABSTRACTSubstantial evidence indicates that antibodies to Plasmodium falciparummerozoite antigens play a role in protection from malaria, although the precise targets and mechanisms mediating immunity remain unclear. Different malaria antigens induce distinct immunoglobulin G (IgG) subclass responses, but the importance of different responses in protective immunity from malaria is not known and the factors determining subclass responses in vivo are poorly understood. We examined IgG and IgG subclass responses to the merozoite antigens MSP1-19 (the 19-kDa C-terminal region of merozoite surface protein 1), MSP2 (merozoite surface protein 2), and AMA-1 (apical membrane antigen 1), including different polymorphic variants of these antigens, in a longitudinal cohort of children in Papua New Guinea. IgG1 and IgG3 were the predominant subclasses of antibodies to each antigen, and all antibody responses increased in association with age and exposure without evidence of increasing polarization toward one subclass. The profiles of IgG subclasses differed somewhat for different alleles of MSP2 but not for different variants of AMA-1. Individuals did not appear to have a propensity to make a specific subclass response irrespective of the antigen. Instead, data suggest that subclass responses to each antigen are generated independently among individuals and that antigen properties, rather than host factors, are the major determinants of IgG subclass responses. High levels of AMA-1-specific IgG3 and MSP1-19-specific IgG1 were strongly predictive of a reduced risk of symptomatic malaria and high-density P. falciparuminfections. However, no antibody response was significantly associated with protection from parasitization per se. Our findings have major implications for understanding human immunity and for malaria vaccine development and evaluation.

Published
2009
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36. Tomographic Investigations at Landfill 4, Hill Air Force Base, Layton, Utah.

Author

WESTON GEOPHYSICAL CORP WESTBOROUGH MA, Jones,Glyn M, Murphy,Vincent J, WESTON GEOPHYSICAL CORP WESTBOROUGH MA, Jones,Glyn M, and Murphy,Vincent J

Abstract

In support of soil classification objectives related to an on going study of non-linear soil response, tomographic techniques were developed and tested using seismic data. The data were collected at three locations at Landfill 4, Hill AFB, Utah. The site is a land-fill waste site which had been isolated from the prevailing ground-water flow by a slurry trench. The objective of this study was to identify the effectiveness of geophysical techniques for seismic velocity measurements and tomographic/imaging analyses. Seismic data were collected between pairs of 50 ft. deep boreholes on either side of the slurry trench. First break picks were analyzed using an iterative back-projection tomographic technique utilizing curved rays. Initial processing revealed that smearing of velocity anomalies between the boreholes occurred because of non-optimum placement of shots and receivers. Adding reasonable constraints to the inversion, however, showed a low-velocity region, terminating between 35 and 40 ft., at the trench location. Diffraction arrivals travelling around the base of the low-velocity region further constrained its depth. Other minor low-velocity zones, possibly indicating layers with increased silt content, were also indicated by the inversion model. This study showed that cross-borehole tomography can be a useful tool in delineating velocity anomalies roughly perpendicular to paths between the boreholes, but that velocity anomalies parallel to the boreholes will be smeared unless additional constraints are imposed. A modification to the data acquisition technique to help overcome this problem would be to use additional high-energy shot-points on the surface between the boreholes.

Published
1987

37. The Effects of Oxygen on the Polymerization of Ethylene in the Presence of Supported Chromium Oxide Catalysis

Author

MASSACHUSETTS UNIV AMHERST SCHOOL OF ENGINEERING, Eldridge,John W., Murphy,Vincent G., MASSACHUSETTS UNIV AMHERST SCHOOL OF ENGINEERING, Eldridge,John W., and Murphy,Vincent G.

Abstract

The polymerization of ethylene over a supported chromium oxide catalyst was studied first in the complete absence of oxygen and then with controlled amounts of oxygen (60 to 600 micro mole/g catalyst) present. The catalyst was prepared by impregnating a microspheroidal silica-alumina (87 - 13 wt. %) with a dilute solution of chromic acid. This raw compound was then activated by heating it in vacuo at 550C. The data indicated that the inhibitory effect of oxygen involved the chemisorption of some oxygen containing species which could in time be displaced by an excess of ethylene. A comparison of the molecular weight distributions of the products with the rates of polymerization at shutdown suggested that higher rates of reaction cause local heating within the reactor, thereby increasing local rates of chain transfer and broadening the distribution. (Author)

Published
1971

40. Uniform system of accounts for villages

Author

Murphy, Vincent B., New York (State). Bureau of Municipal Accounts, Murphy, Vincent B., and New York (State). Bureau of Municipal Accounts

Abstract

Originally published by: New York (State). Bureau of Municipal Accounts

41. Uniform system of accounts for villages

Author

Murphy, Vincent B., New York (State). Bureau of Municipal Accounts, Murphy, Vincent B., and New York (State). Bureau of Municipal Accounts

Abstract

Originally published by: New York (State). Bureau of Municipal Accounts

42. Uniform system of accounts for villages

Author

Murphy, Vincent B., New York (State). Bureau of Municipal Accounts, Murphy, Vincent B., and New York (State). Bureau of Municipal Accounts

Abstract

Originally published by: New York (State). Bureau of Municipal Accounts

43. Uniform system of accounts for villages

Author

Murphy, Vincent B., New York (State). Bureau of Municipal Accounts, Murphy, Vincent B., and New York (State). Bureau of Municipal Accounts

Abstract

Originally published by: New York (State). Bureau of Municipal Accounts

46. LETTERS TO THE EDITOR.

Author

Murphy, Vincent, Messner, Tom, Nichols, Dave, Giordano, Nancy, Amadio, Martin, Michelson, James A., Lamachia, Joe, Hernandez, Bayardo, Harmon, Mike, Eppstein, Dick, and Siegel, Rita Sue

Subjects
*ADVERTISING, *SALES promotion, *PUBLIC opinion, *SURVEYS
Abstract

Presents a survey on the public's opinion on the selection of former Chairman Lee lacocca for the advertisement of DaimlerChrysler. Risk for choosing Lee lacocca for the advertisement, according to Dave Nichols of Denver, Colorado; Disadvantage of the selection of Lee lacocca, according to Nancy Giordano, senior vice president and director of DaileyLAB Dailey & Associates; Insignificance of the image of Lee lacocca to younger buyers, according to James A. Michelson,, president of SMZ Advertising.

Published
2005

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