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1. Subacute thyroiditis in the SARS-CoV-2 era: a multicentre prospective study

Author

De Vincentis, Sara, primary, Loiacono, Simona, additional, Zanni, Eleonora, additional, Sueri, Roberta, additional, Monzani, Maria Laura, additional, Santi, Daniele, additional, Muller, Ilaria, additional, Di Marco, Francesco, additional, Crivicich, Erica, additional, Armenti, Mirco, additional, Pagotto, Uberto, additional, Tucci, Lorenzo, additional, Cecchetti, Carolina, additional, Trenti, Tommaso, additional, Pecoraro, Valentina, additional, Canu, Giulia, additional, Simoni, Manuela, additional, and Brigante, Giulia, additional

Published
2024
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3. Autoimmune responses to thyroid/breast shared antigens to develop novel and specific therapies and diagnostics

Author

Muller, Ilaria

Subjects
616.07, QR180 Immunology, RM Therapeutics. Pharmacology
Abstract

An association between breast cancer (BC) and thyroid autoimmunity (TA) has been frequently observed and several small-scale studies correlated the presence of thyroid peroxidase (TPO) autoantibodies (TPOAb) with an improved BC outcome. The presence of an immune response to shared thyroid/breast antigens has been hypothesized: both tissues express the sodium iodide symporter (NIS) and have a peroxidase activity: TPO in thyroid and lactoperoxidase (LPO) in breast. I have identified 3 possibilities: i) BC patients with TPOAb may also have autoantibodies to NIS (NISAb) ii) BC may express TPO iii) TPOAb may cross-react with LPO in BC. This thesis aimed to identify the TA/BC shared antigen(s) and also investigated the prognostic role of TPOAb in a large cohort of BC patients. The presence of NISAb was investigated by flow cytometry using CHO cells stably transfected with human NIS. No positive response was obtained in 42 patients with BC and/or TA, therefore NIS is unlikely to be an antigen. TPO transcripts (RT-PCR, QPCR, LongRange PCR) and protein (western blot, immunohistochemistry, immunofluorescence) were detected in BC tissues but at levels 104 times less than in thyroid tissue. TPO was also expressed in adipose tissue and different cancers. Some potentially BC specific TPO isoforms were identified. The observational large-scale study conducted on 1974 women affected with BC did not reveal any evidence for a significant impact of TPOAb and/or thyroid function on BC prognosis. In conclusion, BC and thyroid tissues share similar properties and could be common targets of TA, with TPO being the most likely common antigen; further studies are needed to clarify the role of tissue-specific TPO isoforms. The roles of TPOAb and thyroid function on BC prognosis have to be reconsidered, maybe focusing on different TA aspects (e.g. goitre, different autoantibodies).

Published
2016

5. Gut Microbiome Associated With Graves Disease and Graves Orbitopathy: The INDIGO Multicenter European Study

Author

Biscarini, Filippo, primary, Masetti, Giulia, additional, Muller, Ilaria, additional, Verhasselt, Hedda Luise, additional, Covelli, Danila, additional, Colucci, Giuseppe, additional, Zhang, Lei, additional, Draman, Mohd Shazli, additional, Okosieme, Onyebuchi, additional, Taylor, Pete, additional, Daumerie, Chantal, additional, Burlacu, Maria-Cristina, additional, Marinò, Michele, additional, Ezra, Daniel George, additional, Perros, Petros, additional, Plummer, Sue, additional, Eckstein, Anja, additional, Salvi, Mario, additional, Marchesi, Julian R, additional, and Ludgate, Marian, additional

Published
2023
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6. Long-term outcome of thyroid abnormalities in patients with severe Covid-19

Author

Muller, Ilaria, primary, Daturi, Anita, additional, Varallo, Matteo, additional, Re, Tiziana E, additional, Dazzi, Davide, additional, Maioli, Sara, additional, Crivicich, Erica, additional, Di Marco, Francesco, additional, Longari, Virgilio, additional, Dazzi, Beatrice, additional, Castellani, Massimo, additional, Mantovani, Giovanna, additional, Arosio, Maura, additional, and Salvi, Mario, additional

Published
2023
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7. Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies

Author

Dayan, Colin M., primary, Lecumberri, Beatriz, additional, Muller, Ilaria, additional, Ganesananthan, Sashiananthan, additional, Hunter, Samuel F., additional, Selmaj, Krzysztof W., additional, Hartung, Hans-Peter, additional, Havrdova, Eva K., additional, LaGanke, Christopher C., additional, Ziemssen, Tjalf, additional, Van Wijmeersch, Bart, additional, Meuth, Sven G., additional, Margolin, David H., additional, Poole, Elizabeth M., additional, Baker, Darren P., additional, and Senior, Peter A., additional

Published
2023
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8. sj-docx-1-mso-10.1177_20552173221142741 - Supplemental material for Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies

Author

Dayan, Colin M., Lecumberri, Beatriz, Muller, Ilaria, Ganesananthan, Sashiananthan, Hunter, Samuel F., Selmaj, Krzysztof W., Hartung, Hans-Peter, Havrdova, Eva K., LaGanke, Christopher C., Ziemssen, Tjalf, Van Wijmeersch, Bart, Meuth, Sven G., Margolin, David H., Poole, Elizabeth M., Baker, Darren P., and Senior, Peter A.

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-1-mso-10.1177_20552173221142741 for Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies by Colin M. Dayan, Beatriz Lecumberri, Ilaria Muller, Sashiananthan Ganesananthan, Samuel F. Hunter, Krzysztof W. Selmaj, Hans-Peter Hartung, Eva K. Havrdova, Christopher C. LaGanke, Tjalf Ziemssen, Bart Van Wijmeersch, Sven G. Meuth, David H. Margolin, Elizabeth M. Poole, Darren P. Baker and Peter A. Senior in Multiple Sclerosis Journal – Experimental, Translational and Clinical

Published
2023
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12. Case Report: A Novel ARMC5 Germline Mutation in a Patient with Primary Bilateral Macronodular Adrenal Hyperplasia and Hypogammaglobulinemia

Author

Vena, Walter, primary, Morelli, Valentina, additional, Carrabba, Maria, additional, Elli, Francesca, additional, Fabio, Giovanna, additional, Muller, Ilaria, additional, Lucca, Camilla, additional, Maffini, Maria Antonia, additional, Lania, Andrea Gerardo, additional, Mantovani, Giovanna, additional, and Arosio, Maura, additional

Published
2022
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13. Therapy With Different Dose Regimens of Rituximab in Patients With Active Moderate-To-Severe Graves’ Orbitopathy

Author

Campi, Irene, primary, Vannucchi, Guia, additional, Muller, Ilaria, additional, Lazzaroni, Elisa, additional, Currò, Nicola, additional, Dainese, Martina, additional, Montacchini, Benedetta, additional, Covelli, Danila, additional, Guastella, Claudio, additional, Pignataro, Lorenzo, additional, Fugazzola, Laura, additional, Arosio, Maura, additional, and Salvi, Mario, additional

Published
2022
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14. Expression of Endogenous Putative TSH Binding Protein in Orbit

Author

Draman, Mohd Shazli, primary, Grennan-Jones, Fiona, additional, Taylor, Peter, additional, Muller, Ilaria, additional, Evans, Sam, additional, Haridas, Anjana, additional, Morris, Daniel S., additional, Rees, D. Aled, additional, Lane, Carol, additional, Dayan, Colin, additional, Zhang, Lei, additional, and Ludgate, Marian, additional

Published
2021
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15. Early Follow-up of Atypical Thyroiditis Induced by SARS-CoV-2

Author

Muller, Ilaria, primary, Cannavaro, Daniele, additional, Dazzi, Davide, additional, Mantovani, Giovanna, additional, Longari, Virgilio, additional, Cuzzocrea, Marco, additional, Re, Tiziana E, additional, Gori, Andrea, additional, Arosio, Maura, additional, and Salvi, Mario Giovanni, additional

Published
2021
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16. CATS II Long-term Anthropometric and Metabolic Effects of Maternal Sub-optimal Thyroid Function in Offspring and Mothers

Author

Muller, Ilaria, primary, Taylor, Peter N, additional, Daniel, Rhian M, additional, Hales, Charlotte, additional, Scholz, Anna, additional, Candler, Toby, additional, Pettit, Rebecca J, additional, Evans, William D, additional, Shillabeer, Dionne, additional, Draman, Mohd S, additional, Dayan, Colin M, additional, Tang, Hiu K C, additional, Okosieme, Onyebuchi, additional, Gregory, John W, additional, Lazarus, John H, additional, Rees, D Aled, additional, and Ludgate, Marian E, additional

Published
2020
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17. Controlled Antenatal Thyroid Screening II: Effect of Treating Maternal Suboptimal Thyroid Function on Child Behavior

Author

Hales, Charlotte, primary, Taylor, Peter N, additional, Channon, Sue, additional, McEwan, Kirsten, additional, Thapar, Anita, additional, Langley, Kate, additional, Muller, Ilaria, additional, Draman, Mohd S, additional, Dayan, Colin, additional, Gregory, John W, additional, Okosieme, Onyebuchi, additional, Lazarus, John H, additional, Rees, D Aled, additional, and Ludgate, Marian, additional

Published
2019
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19. Alemtuzumab-induced thyroid dysfunction exhibits distinctive clinical and immunological features

Author

Pariani, Nadia, Willis, Mark, Muller, Ilaria, Healy, Sarah, Nasser, Taha, McGowan, Anne, Lyons, Greta, Jones, Joanne, Chatterjee, Krishna, Dayan, Colin, Robertson, Neil, Coles, Alasdair, Moran, Carla, Jones, Joanna [0000-0003-4974-1371], Chatterjee, Krishna [0000-0002-2654-8854], Coles, Alasdair [0000-0003-4738-0760], and Apollo - University of Cambridge Repository

Subjects
Thyroid, Adult, Male, Thyroiditis, Multiple Sclerosis, Middle Aged, Thyroid Diseases, Graves Disease, Young Adult, Disease Progression, Humans, Female, Alemtuzumab, Clinical Research Articles, Retrospective Studies
Abstract

Context Alemtuzumab, a highly effective treatment for multiple sclerosis (MS), predisposes to Graves disease (GD), with a reportedly indolent course. Objective To determine the type, frequency, and course of thyroid dysfunction (TD) in a cohort of alemtuzumab-treated patients with MS in the United Kingdom. Design Case records of alemtuzumab-treated patients who developed TD were reviewed. Results A total of 41.1% (102 out of 248; 80 female and 22 male) of patients developed TD, principally GD (71.6%). Median onset was 17 months (range 2 to 107) following the last dose, with the majority (89%) within 3 years. Follow-up data (range 6 to 251 months) were available in 71 case subjects, of whom 52 (73.2%) developed GD: 10 of these (19.2%) had fluctuating TD. All 52 patients with GD commenced antithyroid drugs (ATDs): 3 required radioiodine (RAI) due to ATD side effects, and drug therapy is ongoing in 2; of those who completed a course, 16 are in remission, 1 developed spontaneous hypothyroidism, and 30 (64%) required definitive or long-term treatment (RAI, n = 17; thyroidectomy, n = 5; and long-term ATDs, n = 8). Three cases of thyroiditis and 16 cases of hypothyroidism were documented: 5 with antithyroid peroxidase antibody positivity only, 10 with positive TSH receptor antibody (TRAb), and 1 of uncertain etiology. Bioassay confirmed both stimulating and blocking TRAb in a subset of fluctuating GD cases. Conclusions Contrary to published literature, we recorded frequent occurrence of GD that required definitive or prolonged ATD treatment. Furthermore, fluctuating thyroid status in GD and unexpectedly high frequency of TRAb-positive hypothyroidism suggested changing activity of TRAb in this clinical context; we have documented the existence of both blocking and stimulating TRAb in these patients., In a retrospective analysis of alemtuzumab-induced thyroid dysfunction, Graves disease with fluctuating status that was relatively refractory to treatment and anti-TSH receptor antibody–positive hypothyroidism was recorded.

Published
2018

22. Controlled Antenatal Thyroid Screening II: Effect of Treating Maternal Suboptimal Thyroid Function on Child Cognition

Author

Hales, Charlotte, primary, Taylor, Peter N, additional, Channon, Sue, additional, Paradice, Ruth, additional, McEwan, Kirsten, additional, Zhang, Lei, additional, Gyedu, Michael, additional, Bakhsh, Ameen, additional, Okosieme, Onyebuchi, additional, Muller, Ilaria, additional, Draman, Mohd S, additional, Gregory, John W, additional, Dayan, Colin, additional, Lazarus, John H, additional, Rees, D Aled, additional, and Ludgate, Marian, additional

Published
2018
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23. Meeting abstracts from the 64th British Thyroid Association Annual Meeting

Author

Bartalena, Luigi, primary, Fliers, Eric, additional, Hellen, Nicola, additional, Taylor, Peter N., additional, Lacey, Arron, additional, Thayer, Daniel, additional, Yusof, Mohd Draman, additional, Tabasum, Arshiya, additional, Muller, Illaria, additional, Marsh, Luke, additional, Ludgate, Marian, additional, Rees, Alex, additional, Boelaert, Kristien, additional, Chan, Shiao, additional, Nelson, Scott, additional, Rees, Aled, additional, Lazarus, John H., additional, Dayan, Colin M., additional, Vaidya, Bijay, additional, Okosieme, Onyebuchi, additional, Poole, Vikki L., additional, Fletcher, Alice, additional, Modasia, Bhavika, additional, Sharma, Neil, additional, Thompson, Rebecca J., additional, Imruetaicharoenchoke, Waraporn, additional, Read, Martin L., additional, McCabe, Christopher J., additional, Smith, Vicki E., additional, Fong, Jim C. W., additional, Nieto, Hannah, additional, Thompson, Rebecca, additional, Watkinson, John C., additional, Turnell, Andrew S., additional, Pariani, Nadia, additional, Willis, Mark, additional, Muller, Ilaria, additional, Healy, Sarah, additional, Nasser, Taha, additional, Jones, Joanne, additional, Chatterjee, Krishna, additional, Dayan, Colin, additional, Robertson, Neil, additional, Coles, Alasdair, additional, Moran, Carla, additional, Hales, Charlotte, additional, Taylor, Peter, additional, Channon, Sue, additional, McEwan, Kirsten, additional, Gregory, John, additional, Draman, Mohd S., additional, Langley, Kate, additional, Thapar, Anita, additional, Lazarus, John, additional, Torlinska, Barbara, additional, Franklyn, Jayne, additional, Coleman, Jamie, additional, Zhang, Lei, additional, Bakhsh, Ameen, additional, Gyedu, Michael, additional, Soto-Pedre, Enrique, additional, Leese, Graham P., additional, Zhou, Kaixin, additional, Smith, Joel A., additional, Hoffman, Jon, additional, Morgan, Neil V., additional, Campbell, Christopher, additional, Wake, Naomi C., additional, Wallis, Yvonne, additional, Maher, Eamonn R., additional, Woodward, Emma R., additional, Tee, Su A., additional, Bishop, David R., additional, Al-Sharefi, Ahmed, additional, Leng, Owain, additional, James, Robert A., additional, Salota, Rashim, additional, Rodin, Andrew, additional, Johri, Nikhil, additional, Hyer, Stephen L., additional, Mcdonnell, Thomas, additional, Ooi, Cheong G., additional, Knight, Bridget A, additional, Shields, Beverley M., additional, Pearce, Elizabeth, additional, Braverman, Lewis, additional, He, Xuemei, additional, and Sturley, Rachel, additional

Published
2017
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26. The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol

Author

Hales, Charlotte, primary, Channon, Sue, additional, Taylor, Peter N, additional, Draman, Mohd S, additional, Muller, Ilaria, additional, Lazarus, John, additional, Paradice, Ruth, additional, Rees, Aled, additional, Shillabeer, Dionne, additional, Gregory, John W, additional, Dayan, Colin M, additional, and Ludgate, Marian, additional

Published
2014
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27. Autoimmune responses to thyroid/breast shared antigens to develop novel and specific therapies and diagnostics

Author

Muller, Ilaria

Subjects
endocrine system, RM, QR180
Abstract

An association between breast cancer (BC) and thyroid autoimmunity (TA) has been frequently observed and several small-scale studies correlated the presence of thyroid peroxidase (TPO) autoantibodies (TPOAb) with an improved BC\ud outcome. The presence of an immune response to shared thyroid/breast antigens has been hypothesized: both tissues express the sodium iodide symporter (NIS) and have a peroxidase activity: TPO in thyroid and lactoperoxidase (LPO) in breast. I have identified 3 possibilities: i) BC patients with TPOAb may also have autoantibodies to NIS (NISAb) ii) BC may express TPO iii) TPOAb may cross-react\ud with LPO in BC. This thesis aimed to identify the TA/BC shared antigen(s) and also investigated the prognostic role of TPOAb in a large cohort of BC patients.\ud The presence of NISAb was investigated by flow cytometry using CHO cells stably transfected with human NIS. No positive response was obtained in 42 patients with\ud BC and/or TA, therefore NIS is unlikely to be an antigen.\ud TPO transcripts (RT-PCR, QPCR, LongRange PCR) and protein (western blot, immunohistochemistry, immunofluorescence) were detected in BC tissues but at levels 104 times less than in thyroid tissue. TPO was also expressed in adipose\ud tissue and different cancers. Some potentially BC specific TPO isoforms were identified.\ud The observational large-scale study conducted on 1974 women affected with BC did not reveal any evidence for a significant impact of TPOAb and/or thyroid function on BC prognosis.\ud In conclusion, BC and thyroid tissues share similar properties and could be common targets of TA, with TPO being the most likely common antigen; further studies are needed to clarify the role of tissue-specific TPO isoforms. The roles of TPOAb and thyroid function on BC prognosis have to be reconsidered, maybe focusing on different TA aspects (e.g. goitre, different autoantibodies).

28. Meeting abstracts from the 64th British Thyroid Association Annual Meeting

Author

Bartalena, Luigi, Fliers, Eric, Hellen, Nicola, Taylor, Peter N, Lacey, Arron, Thayer, Daniel, Yusof, Mohd Draman, Tabasum, Arshiya, Muller, Illaria, Marsh, Luke, Ludgate, Marian, Rees, Alex, Boelaert, Kristien, Chan, Shiao, Nelson, Scott, Rees, Aled, Lazarus, John H, Dayan, Colin M, Vaidya, Bijay, Okosieme, Onyebuchi, Poole, Vikki L, Fletcher, Alice, Modasia, Bhavika, Sharma, Neil, Thompson, Rebecca J, Imruetaicharoenchoke, Waraporn, Read, Martin L, McCabe, Christopher J, Smith, Vicki E, Fong, Jim CW, Nieto, Hannah, Thompson, Rebecca, Watkinson, John C, Turnell, Andrew S, Pariani, Nadia, Willis, Mark, Muller, Ilaria, Healy, Sarah, Nasser, Taha, Jones, Joanne, Chatterjee, Krishna, Dayan, Colin, Robertson, Neil, Coles, Alasdair, Moran, Carla, Hales, Charlotte, Taylor, Peter, Channon, Sue, McEwan, Kirsten, Gregory, John, Draman, Mohd S, Langley, Kate, Thapar, Anita, Lazarus, John, Torlinska, Barbara, Franklyn, Jayne, Coleman, Jamie, Zhang, Lei, Bakhsh, Ameen, Gyedu, Michael, Soto-Pedre, Enrique, Leese, Graham P, Zhou, Kaixin, Smith, Joel A, Hoffman, Jon, Morgan, Neil V, Campbell, Christopher, Wake, Naomi C, Wallis, Yvonne, Maher, Eamonn R, Woodward, Emma R, Tee, Su A, Bishop, David R, Al-Sharefi, Ahmed, Leng, Owain, James, Robert A, Salota, Rashim, Rodin, Andrew, Johri, Nikhil, Hyer, Stephen L, Mcdonnell, Thomas, Ooi, Cheong G, Knight, Bridget A, Shields, Beverley M, Pearce, Elizabeth, Braverman, Lewis, He, Xuemei, and Sturley, Rachel

Subjects
3205 Medical Biochemistry and Metabolomics, 32 Biomedical and Clinical Sciences, Meeting Abstracts, 3202 Clinical Sciences
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29. Alemtuzumab-Induced Thyroid Dysfunction Exhibits Distinctive Clinical and Immunological Features.

Author

Pariani N, Willis M, Muller I, Healy S, Nasser T, McGowan A, Lyons G, Jones J, Chatterjee K, Dayan C, Robertson N, Coles A, and Moran C

Subjects
Adult, Disease Progression, Female, Graves Disease chemically induced, Graves Disease epidemiology, Graves Disease immunology, Graves Disease pathology, Humans, Male, Middle Aged, Multiple Sclerosis epidemiology, Multiple Sclerosis immunology, Retrospective Studies, Thyroid Diseases epidemiology, Thyroiditis chemically induced, Thyroiditis epidemiology, Thyroiditis immunology, Thyroiditis pathology, Young Adult, Alemtuzumab adverse effects, Multiple Sclerosis drug therapy, Thyroid Diseases chemically induced, Thyroid Diseases immunology, Thyroid Diseases pathology
Abstract

Context: Alemtuzumab, a highly effective treatment for multiple sclerosis (MS), predisposes to Graves disease (GD), with a reportedly indolent course., Objective: To determine the type, frequency, and course of thyroid dysfunction (TD) in a cohort of alemtuzumab-treated patients with MS in the United Kingdom., Design: Case records of alemtuzumab-treated patients who developed TD were reviewed., Results: A total of 41.1% (102 out of 248; 80 female and 22 male) of patients developed TD, principally GD (71.6%). Median onset was 17 months (range 2 to 107) following the last dose, with the majority (89%) within 3 years. Follow-up data (range 6 to 251 months) were available in 71 case subjects, of whom 52 (73.2%) developed GD: 10 of these (19.2%) had fluctuating TD. All 52 patients with GD commenced antithyroid drugs (ATDs): 3 required radioiodine (RAI) due to ATD side effects, and drug therapy is ongoing in 2; of those who completed a course, 16 are in remission, 1 developed spontaneous hypothyroidism, and 30 (64%) required definitive or long-term treatment (RAI, n = 17; thyroidectomy, n = 5; and long-term ATDs, n = 8). Three cases of thyroiditis and 16 cases of hypothyroidism were documented: 5 with antithyroid peroxidase antibody positivity only, 10 with positive TSH receptor antibody (TRAb), and 1 of uncertain etiology. Bioassay confirmed both stimulating and blocking TRAb in a subset of fluctuating GD cases., Conclusions: Contrary to published literature, we recorded frequent occurrence of GD that required definitive or prolonged ATD treatment. Furthermore, fluctuating thyroid status in GD and unexpectedly high frequency of TRAb-positive hypothyroidism suggested changing activity of TRAb in this clinical context; we have documented the existence of both blocking and stimulating TRAb in these patients.

Published
2018
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