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Your search keyword '"Morten Jannik Bjerrum"' showing total 2 results
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2 results on '"Morten Jannik Bjerrum"'

1. MicroRNA Biomarkers in Neurodegenerative Diseases and Emerging Nano-Sensors Technology

Author

Pratik Shah, Seok Keun Cho, Peter Waaben Thulstrup, Morten Jannik Bjerrum, Phil Hyu Lee, Ju-Hee Kang, Yong-Joo Bhang, and Seong Wook Yang

Subjects
miRNAs, neurodegenerative diseases, silver nanoclusters, DNA sensor, Neurology. Diseases of the nervous system, RC346-429
Abstract

MicroRNAs (miRNAs) are essential small RNA molecules (20–24 nt) that negatively regulate the expression of target genes at the post-transcriptional level. Due to their roles in a variety of biological processes, the aberrant expression profiles of miRNAs have been identified as biomarkers for many diseases, such as cancer, diabetes, cardiovascular disease and neurodegenerative diseases. In order to precisely, rapidly and economically monitor the expression of miRNAs, many cutting-edge nanotechnologies have been developed. One of the nanotechnologies, based on DNA encapsulated silver nanoclusters (DNA/AgNCs), has increasingly been adopted to create nanoscale bio-sensing systems due to its attractive optical properties, such as brightness, tuneable emission wavelengths and photostability. Using the DNA/AgNCs sensor methods, the presence of miRNAs can be detected simply by monitoring the fluorescence alteration of DNA/AgNCs sensors. We introduce these DNA/ AgNCs sensor methods and discuss their possible applications for detecting miRNA biomarkers in neurodegenerative diseases.

Published
2017
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2. Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization

Author

Cagla Sahin, Eva Christina Østerlund, Nicklas Österlund, Joana Costeira-Paulo, Jannik Nedergaard Pedersen, Gunna Christiansen, Janni Nielsen, Anne Louise Grønnemose, Søren Kirk Amstrup, Manish K. Tiwari, R. Shyama Prasad Rao, Morten Jannik Bjerrum, Leopold L. Ilag, Michael J. Davies, Erik G. Marklund, Jan Skov Pedersen, Michael Landreh, Ian Max Møller, Thomas J. D. Jørgensen, and Daniel Erik Otzen

Subjects
METAL-CATALYZED OXIDATION, Amyloid, Amyloid/chemistry, Biophysics, Biochemistry and Molecular Biology, Parkinson Disease, General Chemistry, Parkinson Disease/metabolism, Biochemistry, Biofysik, Catalysis, alpha-Synuclein/chemistry, Colloid and Surface Chemistry, OLIGOMERS, Structural Biology, BINDING, alpha-Synuclein, Humans, Tyrosine, FIBRILLATION, Tyrosine/analogs & derivatives, COPPER(II), Biokemi och molekylärbiologi, Strukturbiologi
Abstract

alpha-Synuclein (alpha-Syn) is an intrinsically disordered protein which self-assembles into highly organized beta-sheet structures that accumulate in plaques in brains of Parkinson's disease patients. Oxidative stress influences alpha-Syn structure and selfassembly; however, the basis for this remains unclear. Here we characterize the chemical and physical effects of mild oxidation on monomeric alpha-Syn and its aggregation. Using a combination of biophysical methods, small-angle X-ray scattering, and native ion mobility mass spectrometry, we find that oxidation leads to formation of intramolecular dityrosine cross-linkages and a compaction of the alpha-Syn monomer by a factor of root 2. Oxidation-induced compaction is shown to inhibit ordered self-assembly and amyloid formation by steric hindrance, suggesting an important role of mild oxidation in preventing amyloid formation.

Published
2022
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