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1. L is different from NP

Author

Montoya, J. Andres

Subjects
Computer Science - Computational Complexity, F.1.3
Abstract

We prove that the class LOGSPACE (L, for short) is different from the class NP.

Published
2024

2. On near-redundancy and identifiability of parametric hazard regression models under censoring

Author

Rubio, F. J., Espindola, J. A., and Montoya, J. A.

Subjects
Statistics - Methodology
Abstract

We study parametric inference on a rich class of hazard regression models in the presence of right-censoring. Previous literature has reported some inferential challenges, such as multimodal or flat likelihood surfaces, in this class of models for some particular data sets. We formalize the study of these inferential problems by linking them to the concepts of near-redundancy and practical non-identifiability of parameters. We show that the maximum likelihood estimators of the parameters in this class of models are consistent and asymptotically normal. Thus, the inferential problems in this class of models are related to the finite-sample scenario, where it is difficult to distinguish between the fitted model and a nested non-identifiable (i.e., parameter-redundant) model. We propose a method for detecting near-redundancy, based on distances between probability distributions. We also employ methods used in other areas for detecting practical non-identifiability and near-redundancy, including the inspection of the profile likelihood function and the Hessian method. For cases where inferential problems are detected, we discuss alternatives such as using model selection tools to identify simpler models that do not exhibit these inferential problems, increasing the sample size, or extending the follow-up time. We illustrate the performance of the proposed methods through a simulation study. Our simulation study reveals a link between the presence of near-redundancy and practical non-identifiability. Two illustrative applications using real data, with and without inferential problems, are presented., Comment: To appear in Biometrical Journal

Published
2023

3. NL Is Strictly Contained in P

Author

Flum, Santiago and Montoya, J. Andres

Subjects
Computer Science - Formal Languages and Automata Theory, 03D15
Abstract

We prove that NL is strictly contained in P. We get this separation as a corollary of the following result: the set of context-free languages is not contained in NL. The reader should recall that CFL is contained in DTIME(n^3), Comment: There is a gap that cannot be fixed

Published
2023

4. Gas Emission Measurement System from Chilla-Juliaca -Peru

Author

Montoya, J. Mendoza, Olsson, A., Mårtensson, S. - G., Zea, K. J. Huanca, Calla, A. R. Rojas, and Chilo, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

In many countries around the world, most of the waste use to be disposed of to landfills, this generate public concern about the health effects of emissions. Landfill gases are produced by the natural bacterial decomposition of waste and it is about half of methane, with the remainder mostly carbon dioxide and minor amounts of other gases. Real-time measurement and modelling of emissions gases in landfills is important. In this work a low cost wireless measurement system is developed using MOS gas sensors (MQ4-1,MQ4-2, MQ5 and MQ9), microcontroller and XBee/HC-12 wireless communications modules. The system can be mounted on an unmanned aircraft (UAV, drone) or deployed as a wireless sensor network. Experiments have been carried out near a closed landfill, which show high gas concentration, Comment: Poster presentation at 22nd IEEE NPSS Real Time Conference, Oct 12-23, 2020

Published
2020

5. Satellite Communications in the New Space Era: A Survey and Future Challenges

Author

Kodheli, O., Lagunas, E., Maturo, N., Sharma, S. K., Shankar, B., Montoya, J. F. Mendoza, Duncan, J. C. Merlano, Spano, D., Chatzinotas, S., Kisseleff, S., Querol, J., Lei, L., Vu, T. X., and Goussetis, G.

Subjects
Electrical Engineering and Systems Science - Signal Processing
Abstract

Satellite communications have recently entered a period of renewed interest motivated by technological advances and nurtured through private investment and ventures. The present survey aims at capturing the state of the art in SatComs, while highlighting the most promising open research topics. Firstly, the main innovation drivers are motivated, such as new constellation types, on-board processing capabilities, nonterrestrial networks and space-based data collection/processing. Secondly, the most promising applications are described i.e. 5G integration, space communications, Earth observation, aeronautical and maritime tracking and communication. Subsequently, an in-depth literature review is provided across five axes: i) system aspects, ii) air interface, iii) medium access, iv) networking, v) testbeds & prototyping. Finally, a number of future challenges and the respective open research topics are described., Comment: Submitted for possible publication in IEEE Communications Surveys & Tutorials

Published
2020

6. A Review on Challenges and Successes in Atomic-Scale Design of Catalysts for Electrochemical Synthesis of Hydrogen Peroxide

Author

Siahrostami, S, Villegas, SJ, Bagherzadeh Mostaghimi, AH, Back, S, Farimani, AB, Wang, H, Persson, KA, and Montoya, J

Subjects
electrochemical synthesis of hydrogen peroxide, oxygen reduction reaction, water oxidation reaction, computational material design, density functional theory, Inorganic Chemistry, Organic Chemistry, Chemical Engineering
Abstract

Hydrogen peroxide is a valuable chemical oxidant with a wide range of applications in a variety of industrial processes, especially in water sanitization. Electrochemical synthesis of hydrogen peroxide (H2O2) through a two-electron oxygen reduction reaction (2e-ORR) or a two-electron water oxidation reaction (2e-WOR) has emerged as an appealing process for onsite production of this chemically valuable oxidant. On-site produced H2O2 can be applied for wastewater treatment in remote locations or any applications where H2O2 is needed as an oxidizing agent. This Review studies the theoretical efforts in understanding the challenges in catalysis for electrochemical synthesis of H2O2 as well as providing design principles for more efficient catalyst materials.

Published
2020

7. On the synchronization of planar automata

Author

Montoya, J. Andres and Nolasco, Christian

Subjects
Computer Science - Formal Languages and Automata Theory
Abstract

Planar automata seems to be representative of the synchronizing behavior of deterministic finite state automata. We conjecture that \v{C}erny's conjecture holds true, if and only if, it holds true for planar automata. In this paper we have gathered some evidence concerning this conjecture. This evidence amounts to show that the class of planar automata is representative of the algorithmic hardness of synchronization, Comment: 17 pages, 2 figures

Published
2016

8. C - 26Combined Effects of HIV and Past Methamphetamine Use Disorder on Frailty, Neurocognition, and Everyday Functioning

Author

Paolillo, E, Saloner, R, Montoya, J, Campbell, L, Pasipanodya, E, Iudicello, J, Moore, R, and Moore, D

Subjects
Biological Psychology, Clinical and Health Psychology, Psychology, Applied and Developmental Psychology, Neurosciences, Cognitive Sciences, Clinical Psychology, Applied and developmental psychology, Biological psychology, Clinical and health psychology
Published
2018

9. Matminer: An open source toolkit for materials data mining

Author

Ward, L, Dunn, A, Faghaninia, A, Zimmermann, NER, Bajaj, S, Wang, Q, Montoya, J, Chen, J, Bystrom, K, Dylla, M, Chard, K, Asta, M, Persson, KA, Snyder, GJ, Foster, I, and Jain, A

Subjects
Data mining, Open source software, Machine learning, Materials informatics, Networking and Information Technology R&D, Bioengineering, Generic health relevance, Materials, Condensed Matter Physics, Optical Physics, Materials Engineering
Abstract

As materials data sets grow in size and scope, the role of data mining and statistical learning methods to analyze these materials data sets and build predictive models is becoming more important. This manuscript introduces matminer, an open-source, Python-based software platform to facilitate data-driven methods of analyzing and predicting materials properties. Matminer provides modules for retrieving large data sets from external databases such as the Materials Project, Citrination, Materials Data Facility, and Materials Platform for Data Science. It also provides implementations for an extensive library of feature extraction routines developed by the materials community, with 47 featurization classes that can generate thousands of individual descriptors and combine them into mathematical functions. Finally, matminer provides a visualization module for producing interactive, shareable plots. These functions are designed in a way that integrates closely with machine learning and data analysis packages already developed and in use by the Python data science community. We explain the structure and logic of matminer, provide a description of its various modules, and showcase several examples of how matminer can be used to collect data, reproduce data mining studies reported in the literature, and test new methodologies.

Published
2018

11. Bayesian molecular clock dating and the divergence times of angiosperms and primates

Author

Barba-Montoya, J. A., Yang, Z., and Telford, M.

Subjects
561
Abstract

The explosive increase of molecular sequence data has produced unprecedented opportunities for addressing a number of evolutionary problems. Specially, the species divergence time estimation is fundamental because our understanding of history of life depends critically on knowledge of the ages of major clades. This thesis explores the use of molecular data (genome-scale datasets), combined with statistical summaries of the fossil record, to date the origin of angiosperms (flowering plants) and the divergence times of its major groups in an attempt to resolve the apparent conflict between the molecular dates and fossil evidence. Moreover, because fossil calibrations are the major source of information for resolving the distances between molecular sequences into estimates of absolute times and absolute rates in molecular clock dating analysis, several strategies for converting fossil calibrations into the prior on times are evaluated. Chapter one introduces the diversity and evolution of angiosperms, reviews the current literature that is based predominantly on systematics, phylogenetics, palaeobotany and plant molecular evolution. In introducing the early evolution of angiosperms this chapter highlights the questions associated with the origin of angiosperms and presents aims of the thesis. Chapter two focuses on molecular clock dating methods. It discusses different approaches for estimating divergence times, with emphasis on Bayesian molecular clock dating methods. Chapter three uses a powerful Bayesian method to analyze a molecular dataset of 83 genes from 644 taxa of vascular plants, combined with a suite of 52 fully-justified fossil calibrations to disentangle the pattern of angiosperm diversification. The results indicate that crown angiosperms originated during the Triassic to the Jurassic interval, long prior to the Cretaceous Terrestrial Revolution. This analysis demonstrates that even though many sources of uncertainty are explored, attempts to control for these factors still do not bring clock estimates and earliest confident fossil occurrences into agreement. A post-Jurassic origin of angiosperms was rejected, supporting the notion of a cryptic early history of angiosperms. The main factors affecting the estimates in this study are also discussed. Subsequently, in chapter four different strategies for summarizing fossil information to construct calibration priors were assessed employing an a priori procedure for deriving accurate calibration densities in Bayesian divergence dating. In general, truncation has a great impact on calibrations so that the effective priors on the calibration node ages after the truncation can be very different from the user-specified calibration densities. The different strategies for generating the effective prior also had considerable impact, leading to very different marginal effective priors. Arbitrary parameters used to implement minimum-bound calibrations were found to have a strong impact upon the prior and posterior of the divergence times. The results highlight the importance of inspecting the joint time prior used by the dating program before any Bayesian dating analysis. Finally, chapter five draws together key finding from chapters three and four, and reviews how this work advances our understanding of the origin and evolution of angiosperms and on molecular clock dating using fossil calibrations. This chapter also highlights new gaps in our understanding of early evolution of angiosperms and in the implementation of fossil calibrations in Bayesian molecular clock dating, and discusses several areas for future research. Overall, this thesis highlights that more room for improvement might lie in refining our knowledge and use of fossil calibrations, the resulting improvements to molecular estimates of timescales will lead to a better understanding of angiosperm evolution. I speculate that these results will also shed light on dating discrepancies in other major clades.

Published
2017

12. The almost-entropic regions are not semialgebraic

Author

Mejia, Carolina and Montoya, J. Andres

Subjects
Computer Science - Information Theory, 94A17, H.1.1, E.4
Abstract

We prove that the almost-entropic region of order four is not semialgebraic, we get as a corollary the well-known Theorem of Matus, which asserts that this region is not polyhedral, Comment: 9 pages The paper has been withdrawn by the authors due to a flaw in the proof of the main result

Published
2015

15. Primary Production

Author

Lewandowski, I., Lippe, M., Montoya, J. Castro, Dickhöfer, U., Langenberger, G., Pucher, J., Schließmann, U., Schmid-Staiger, U., Derwenskus, F., Lippert, C., and Lewandowski, Iris, editor

Published
2018
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17. Getting Ready for the Next Step: The Eradication of Feral Cats on Large and Highest Priority Mexican Islands

Author

Barredo-Barberena, J. M., Ortiz-Alcaraz, A. A., Hernández-Montoya, J. C., Luna-Mendoza, L., and Aguirre-Muñoz, A.

Subjects
Curiosity® bait, eradication, Eradicat® bait, Felis catus, feral cats, island restoration, Mexican islands, Mexico, non-toxic bait trials
Abstract

Mexican islands’ biodiversity is very rich and diverse; several reptile, bird, and mammal endemic species live on them. However, ecological and evolutionary processes have been negatively affected by invasive species. To date, more than 20 island endemics, including mammals, birds and reptiles, have gone extinct on Mexican islands. As a very opportunistic predator that adapts easily to different environments, the feral cat is one of the most lethal invasive species. Restoration of island ecosystems can be achieved effectively by the eradication of this noxious species. In Mexico, 18 islands (

Published
2012

20. Food web complexity and higher-level ecosystem services

Author

Montoya, J M, Rodriguez, M A, and Hawkins, Bradford A.

Subjects
biodiversity, clustering, ecosystem function, food web structure, higher-level interactions, indirect effects, omnivory, parasitoids
Abstract

Studies mostly focused on communities of primary producers have shown that species richness provides and promotes fundamental ecosystem services. However, we know very little about the factors influencing ecosystem services provided by higher trophic levels in natural food webs. Here we present evidence that differences in food web structure and the richness of herbivores in 19 plant-herbivore-parasitoid food webs influence the service supplied by natural enemies, namely, the parasitism rates on hosts. Specifically, we find that parasitoids function better in simple food webs than in complex ones, a result relevant to biological control practice. More generally, we show that species richness per se only contributes partially to the understanding of higher-level ecosystem services in multitrophic communities, and that changes in food web complexity should also be taken into account when predicting the effects of human-driven disturbances in natural communities.

Published
2003

25. Asociación entre diabetes mellitus gestacional y enfermedad periodontal: revisión sistemática

Author

León-Ríos, X. A., da Silva Pires, S., and Gil-Montoya, J. A.

Subjects
Pregnant women, Systematic review, Hyperglycaemia, Periodontal disease, Gestational diabetes mellitus
Abstract

Aim: To determine whether there is an association between periodontal disease in pregnant women and the development of gestational diabetes mellitus during their pregnancy. Objetive: To determine if there is an association between periodontal disease in pregnant women and the development of gestational diabetes mellitus during her pregnancy Methods: The present systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA) guidelines. Four electronic data bases were searched: MEDLINE (via PubMed), Cochrane Library, Scopus and Web of Science, through February 2021. Eligible studies were assessed for methodological quality using the Newcastle-Ottawa scale. Results: From 161 studies, 8 were eligible: 3 case-control, 2 cross-sectional and 3 cohort studies. Most of the studies supported an association between periodontitis and GDM. Conclusion: Periodontitis is associated with increased risk for GDM compared to woman without periodontitis. Future robust studies with different designs in distinct populations are needed to enlarge on these findings. Objetivo: Determinar si existe asociación entre la enfermedad periodontal en las gestantes y el desarrollo de diabetes mellitus gestacional durante su embarazo. Materiales y métodos: La presente revisión se realizó en base a las directrices de la declaración Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA). Se realizó una búsqueda sistemática en cuatro bases de datos: MEDLINE (vía PubMed), Cochrane Library, Scopus y Web of Science. Se incluyeron todos los trabajos encontrados hasta marzo del 2021. Los estudios que resultaron elegibles fueron evaluados a través de la escala de Newcastle-Ottawa en cuanto a su calidad metodológica. Resultados: De 161 estudios resultaron elegibles un total de 8 estudios, 3 de tipo caso-control, 2 de tipo transversal y 3 de tipo cohorte. En la mayoría de los estudios se verificó una asociación entre EP y DMG. Conclusión: La enfermedad periodontal aumenta el riesgo de desarrollar diabetes mellitus gestacional. Es necesario realizar más estudios con diferentes diseños, enfoque multicéntrico y distintas poblaciones para profundizar esta asociación. Revisión por pares

Published
2022

28. Development and characterization of cell models harbouring mtDNA deletions for i n vitro study of Pearson syndrome

Author

Hernández-Ainsa C, López-Gallardo E, García-Jiménez MC, Climent-Alcalá FJ, Rodríguez-Vigil C, García Fernández de Villalta M, Artuch-Iriberri R, Montoya J, Ruiz-Pesini E, and Emperador S

Subjects
Pearson syndrome, iPSCs, Cybrid, mtDNA deletion, Mitochondrial DNA, Mitochondrial disease
Abstract

Pearson syndrome is a rare multisystem disease caused by single large-scale mitochondrial DNA deletions (SLSMDs). The syndrome presents early in infancy and is mainly characterised by refractory sideroblastic anaemia. Prognosis is poor and treatment is supportive, thus the development of new models for the study of Pearson syndrome and new therapy strategies is essential. In this work, we report three different cell models carrying an SLMSD: fibroblasts, transmitochondrial cybrids and induced pluripotent stem cells (iPSCs). All studied models exhibited an aberrant mitochondrial ultrastructure and defective oxidative phosphorylation system function, showing a decrease in different parameters, such as mitochondrial ATP, respiratory complex IV activity and quantity or oxygen consumption. Despite this, iPSCs harbouring 'common deletion ' were able to differentiate into three germ layers. Additionally, cybrid clones only showed mitochondrial dysfunction when heteroplasmy level reached 70%. Some differences observed among models may depend on their metabolic profile; therefore, we consider that these three models are useful for the in vitro study of Pearson syndrome, as well as for testing new specific therapies.

Published
2022

29. Strong floristic distinctiveness across Neotropical successional forests

Author

Jakovac, C.C., Meave, J.A., Bongers, F., Letcher, S.G., Dupuy, J.M., Piotto, D., Rozendaal, D.M.A., Peña-Claros, M., Craven, D., Santos, B.A., Siminski, A., Fantini, A.C., Rodrigues, A.C., Hernández-Jaramillo, A., Idárraga, A., Junqueira, A.B., Zambrano, A.M.A., De Jong, B.H.J., Pinho, B.X., Finegan, B., Castellano-Castro, C., Zambiazi, D.C., Dent, D.H., García, D.H., Kennard, D., Delgado, D., Broadbent, E.N., Ortiz-Malavassi, E., Pérez-García, E.A., Lebrija-Trejos, E., Berenguer, E., Marín-Spiotta, E., Alvarez-Davila, E., De Sá Sampaio, E.V., Melo, F., Elias, F., França, F., Oberleitner, F., Mora, F., Williamson, G.B., Dalla Colletta, G., Cabral, G.A.L., Derroire, G., Fernandes, G.W., Van Der Wal, H., Teixeira, H.M., Vester, H.F.M., García, H., Vieira, I.C.G., Jiménez-Montoya, J., De Almeida-Cortez, J.S., Hall, J.S., Chave, J., Zimmerman, J.K., Nieto, J.E., Ferreira, J., Rodríguez-Velázquez, J., Ruíz, J., Barlow, J., Aguilar-Cano, J., Hernández-Stefanoni, J.L., Engel, J., Becknell, J.M., Zanini, K., Lohbeck, M., Tabarelli, M., Romero-Romero, M.A., Uriarte, M., Veloso, M.D.M., Espírito-Santo, M.M., Van Der Sande, M.T., Van Breugel, M., Martínez-Ramos, M., Schwartz, N.B., Norden, N., Pérez-Cárdenas, N., González-Valdivia, N., Petronelli, P., Balvanera, P., Massoca, P., Brancalion, P.H.S., Villa, P.M., Hietz, P., Ostertag, R., López-Camacho, R., César, R.G., Mesquita, R., Chazdon, R.L., Muñoz, R., DeWalt, S.J., Müller, S.C., Durán, S.M., Martins, S.V., Ochoa-Gaona, S., Rodríguez-Buritica, S., Aide, T.M., Bentos, T.V., Moreno, V.D.S., Granda, V., Thomas, W., Silver, W.L., Nunes, Y.R.F., Poorter, L., Environmental Sciences, Universidade Federal de Santa Catarina = Federal University of Santa Catarina [Florianópolis] (UFSC), Wageningen University and Research [Wageningen] (WUR), Centro de Investigacion Cientifica de Yucatan (CICY), Botanique et Modélisation de l'Architecture des Plantes et des Végétations (UMR AMAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université de Montpellier (UM), Federal University of Pernambuco [Recife], Ecologie des forêts de Guyane (UMR ECOFOG), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département Environnements et Sociétés (Cirad-ES), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), New York Botanical Garden (NYBG), University of California [Berkeley] (UC Berkeley), University of California (UC), Universidade Estadual de Montes Claros, and Environmental Sciences

Subjects
Multidisciplinary, Land, Evolution, America, Dispersal, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, PE&RC, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, Forest Ecology and Forest Management, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, Plant Production Systems, Plant diversity, Size, Plantaardige Productiesystemen, Life Science, Bosecologie en Bosbeheer, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Crop and Weed Ecology
Abstract

International audience; Forests that regrow naturally on abandoned fields are important for restoring biodiversity and ecosystem services, but can they also preserve the distinct regional tree floras? Using the floristic composition of 1215 early successional forests (≤20 years) in 75 human-modified landscapes across the Neotropic realm, we identified 14 distinct floristic groups, with a between-group dissimilarity of 0.97. Floristic groups were associated with location, bioregions, soil pH, temperature seasonality, and water availability. Hence, there is large continental-scale variation in the species composition of early successional forests, which is mainly associated with biogeographic and environmental factors but not with human disturbance indicators. This floristic distinctiveness is partially driven by regionally restricted species belonging to widespread genera. Early secondary forests contribute therefore to restoring and conserving the distinctiveness of bioregions across the Neotropical realm, and forest restoration initiatives should use local species to assure that these distinct floras are maintained.

Published
2022

31. THE JAGUAR (PANTHERA ONCA) IN SAN LUIS POTOSÍ, MEXICO

Author

Villordo-Galván, J. Agustín, Rosas-Rosas, Octavio C., Clemente-Sánchez, Fernando, Martínez-Montoya, J. Felipe, Tarango-Arámbula, Luis A., Mendoza-Martínez, Germán, Sánchez-Hermosillo, Manuel D., and Bender, Louis C.

Published
2010

32. Multidimensional tropical forest recovery

Author

Poorter, L., Craven, D., Jakovac, C.C., van der Sande, M.T., Amissah, L., Bongers, F., Chazdon, R.L., Farrior, C.E., Kambach, S., Meave, J.A., Muñoz, R., Norden, N., Rüger, N., van Breugel, M., Zambrano, A.M.A., Amani, B., Andrade, J.L., Brancalion, P.H.S., Broadbent, E.N., de Foresta, H., Dent, D.H., Derroire, G., DeWalt, S.J., Dupuy, J.M., Durán, S.M., Fantini, A.C., Finegan, B., Hernández-Jaramillo, A., Hernández-Stefanoni, J.L., Hietz, P., Junqueira, A.B., N’dja, J.K., Letcher, S.G., Lohbeck, M., López-Camacho, R., Martínez-Ramos, M., Melo, F.P.L., Mora, F., Müller, S.C., N’Guessan, A.E., Oberleitner, F., Ortiz-Malavassi, E., Pérez-García, E.A., Pinho, B.X., Piotto, D., Powers, J.S., Rodríguez-Buriticá, S., Rozendaal, D.M.A., Ruíz, J., Tabarelli, M., Teixeira, H.M., de Sá Barretto Sampaio, E.V., van der Wal, H., Villa, P.M., Fernandes, G.W., Santos, B.A., Aguilar-Cano, J., de Almeida-Cortez, J.S., Alvarez-Davila, E., Arreola-Villa, F., Balvanera, P., Becknell, J.M., Cabral, G.A.L., Castellanos-Castro, C., de Jong, B.H.J., Nieto, J.E., Espírito-Santo, M.M., Fandino, M.C., García, H., García-Villalobos, D., Hall, J.S., Idárraga, A., Jiménez-Montoya, J., Kennard, D., Marín-Spiotta, E., Mesquita, R., Nunes, Y.R.F., Ochoa-Gaona, S., Peña-Claros, M., Pérez-Cárdenas, N., Rodríguez-Velázquez, J., Villanueva, L.S., Schwartz, N.B., Steininger, M.K., Veloso, M.D.M., Vester, H.F.M., Vieira, I.C.G., Williamson, G.B., Zanini, K., Hérault, B., Environmental Sciences, Environmental Sciences, Wageningen University and Research [Wageningen] (WUR), Universidad Mayor [Santiago de Chile], Universidade Federal de Santa Catarina = Federal University of Santa Catarina [Florianópolis] (UFSC), CSIR- Forestry Research Institute of Ghana, Tree Improvement and seed Technology Division, UST, University of Connecticut (UCONN), University of Texas at Austin [Austin], German Centre for Integrative Biodiversity Research (iDiv), Universidad Nacional Autónoma de México (UNAM), Instituto Vasco de Investigación de Recursos Biológicos Alexander von Humboldt, Universität Leipzig [Leipzig], Smithsonian Tropical Research Institute, University of Florida [Gainesville] (UF), Université Jean Lorougnon Guédé (UJloG ), University of São Paulo (USP), Botanique et Modélisation de l'Architecture des Plantes et des Végétations (UMR AMAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Forêts et Sociétés (UPR Forêts et Sociétés), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Département Environnements et Sociétés (Cirad-ES), Institut national polytechnique Félix Houphouët-Boigny, and Institut National Polytechnique Félix Houphouët-Boigny

Subjects
0106 biological sciences, Reconstitution forestière, 010504 meteorology & atmospheric sciences, forêt tropicale, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, 010603 evolutionary biology, 01 natural sciences, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, Tropical forest, K01 - Foresterie - Considérations générales, Life Science, Bosecologie en Bosbeheer, K70 - Dégâts causés aux forêts et leur protection, Deforestation, 0105 earth and related environmental sciences, Multidisciplinary, Resilience, Farm Systems Ecology Group, Réhabilitation des forêts, 15. Life on land, South America, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, PE&RC, Forest Ecology and Forest Management, Plant Production Systems, 13. Climate action, Plantaardige Productiesystemen, Africa, P01 - Conservation de la nature et ressources foncières, Secondary forests, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Crop and Weed Ecology, Restauration du paysage forestier, Zone tropicale
Abstract

International audience; Tropical forests disappear rapidly because of deforestation, yet they have the potential to regrow naturally on abandoned lands. We analyze how 12 forest attributes recover during secondary succession and how their recovery is interrelated using 77 sites across the tropics. Tropical forests are highly resilient to low-intensity land use; after 20 years, forest attributes attain 78% (33 to 100%) of their old-growth values. Recovery to 90% of old-growth values is fastest for soil (12 decades). Network analysis shows three independent clusters of attribute recovery, related to structure, species diversity, and species composition. Secondary forests should be embraced as a low-cost, natural solution for ecosystem restoration, climate change mitigation, and biodiversity conservation.

Published
2021

36. Establishing the Injury Severity of Subaxial Cervical Spine Trauma: Validating the Hierarchical Nature of the AO Spine Subaxial Cervical Spine Injury Classification System

Author

Schroeder, G. D., Canseco, J. A., Patel, P. D., Divi, S. N., Karamian, B. A., Kandziora, F., Vialle, E. N., Oner, F. C., Schnake, K. J., Dvorak, M. F., Chapman, J. R., Benneker, L. M., Rajasekaran, S., Kepler, C. K., Vaccaro, A. R., Abdelgawaad, A. S., Abdul, W., Abdulsalam, A., Abeid, M., Ackshota, N., Acosta, O., Akman, Y., Aldahamsheh, O., Alhammoud, A., Aleixo, H., Alexander, H., Alkharsawi, M., Alsammak, W., Amadou, H., Amin, M., Arbatin, J., Atan, A., Athanasiou, A., Bas, P., Bazan, P., Benzakour, T., Benzarti, S., Bernucci, C., Bosco, A., Butler, J., Castillo, A., Cawley, D., Chek, W., Chen, J., Cheng, C., Cheung, J., Chong, C., Corluka, S., Corredor, J., Costa, B., Curri, C., Dawoud, A., Delgado-Fernandez, J., Demiroz, S., Desai, A., Diez-Ulloa, M., Dimas, N., Diniz, S., Direito-Santos, B., Duerinck, J., El-Hewala, T., El-Shamly, M., El-Sharkawi, M., Espinosa, G., Estefan, M., Fang, T., Fernandes, M., Fernandez, N., Ferreira, M., Figueiredo, A., Fiorenza, V., Francis, J., Franz, S., Freedman, B., Fu, L., Fuego, S., Gahlot, N., Ganau, M., Garcia-Pallero, M., Garg, B., Gidvani, S., Giera, B., Godinho, A., Goni, M., Gonzalez, M., Gonzalez, R., Gopalakrishnan, D., Grin, A., Grozman, S., Gruenberg, M., Grundshtein, A., Guasque, J., Guerra, O., Guiroy, A., Hackla, S., Harris, C., Harrop, J., Hassan, W., Henine, A., Hickman, Z., Igualada, C., James, A., Jetjumnong, C., Kaen, A., Karmacharya, B., Kilincer, C., Klezl, Z., Koerner, J., Konrads, C., Krappel, F., Kruyt, M., Krywinski, F., Kundangar, R., Landriel, F., Lindtner, R., Linhares, D., Llombart-Blanco, R., Lopez, W., Lotan, R., Lourido, J., Luna, L., Magashi, T., Majer, C., Mandizvidza, V., Manilha, R., Mannara, F., Margetis, K., Medina, F., Milano, J., Miyakoshi, N., Moisa, H., Montemurro, N., Montoya, J., Morais, J., Morande, S., Msuya, S., Mubarak, M., Mulbah, R., Murugan, Y., Nacer, M., Neves, N., Nicassio, N., Niemeier, T., Olorunsogo, M., Orosco, D., Ozdener, K., Paez, R., Panchal, R., Paterakis, K., Pemovska, E., Pereira, P., Perovic, D., Perozo, J., Pershin, A., Phedy, P., Picazo, D., Pitti, F., Platz, U., Pluderi, M., Ponnusamy, G., Popescu, E., Ramakrishnan, S., Ramieri, A., Rebholz, B., Ricciardi, G., Ricciardi, D., Robinson, Y., Rodriguez, L., Rodrigues-Pinto, R., Romero, I., Rosas, R., Russo, S., Rutges, J., Sartor, F., Shariati, B., Sharma, J., Shoaib, M., Smith, S., Sorimachi, Y., Sribastav, S., Steiner, C., Subbiah, J., Subramanian, P., Suri, T., Tannoury, C., Tokala, D., Toluse, A., Ungurean, V., Vahl, J., Valacco, M., Valdez, C., Vernengo-Lezica, A., Veroni, A., Vieira, R., Viswanadha, A., Wagner, S., Wamae, D., Weening, A., Weidert, S., W. -T., Wu, M. -H., Wu, Yuan, H., Yuh, S. -J., Yurac, R., Zarate-Kalfopulos, B., Ziabrov, A., Zubairi, A., Surgical clinical sciences, Neuroprotection & Neuromodulation, and Neurosurgery

Subjects
Adult, Male, Facet (geometry), medicine.medical_specialty, Cross-sectional study, Clinical Neurology, 610 Medicine & health, Cervical spine injury, cervical spine, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Injury Severity Score, Surveys and Questionnaires, Severity of illness, Validation, medicine, Humans, Orthopedics and Sports Medicine, Spinal cord injury, Spinal Cord Injuries, 030222 orthopedics, business.industry, Reproducibility of Results, AO spine subaxial cervical spine injury, Cervical spine, Classification system, Injury severity score, Trauma, Cervical Vertebrae, Cross-Sectional Studies, Female, medicine.disease, medicine.anatomical_structure, trauma, Neurology (clinical), Radiology, business, 030217 neurology & neurosurgery, Cervical vertebrae
Abstract

STUDY DESIGN Global cross-sectional survey. OBJECTIVE To validate the AO Spine Subaxial Cervical Spine Injury Classification by examining the perceived injury severity by surgeon across AO geographical regions and practice experience. SUMMARY OF BACKGROUND DATA Previous subaxial cervical spine injury classifications have been limited by subpar interobserver reliability and clinical applicability. In an attempt to create a universally validated scheme with prognostic value, AO Spine established a subaxial cervical spine injury classification involving four elements: (1) injury morphology, (2) facet injury involvement, (3) neurologic status, and (4) case-specific modifiers. METHODS A survey was sent to 272 AO Spine members across all geographic regions and with a variety of practice experience. Respondents graded the severity of each variable of the classification system on a scale from zero (low severity) to 100 (high severity). Primary outcome was to assess differences in perceived injury severity for each injury type over geographic regions and level of practice experience. RESULTS A total of 189 responses were received. Overall, the classification system exhibited a hierarchical progression in subtype injury severity scores. Only three subtypes showed a significant difference in injury severity score among geographic regions: F3 (floating lateral mass fracture, p:0.04), N3 (incomplete spinal cord injury, p:0.03), and M2 (critical disk herniation, p:0.04). When stratified by surgeon experience, pairwise comparison showed only 2 morphological subtypes, B1 (bony posterior tension band injury, p:0.02) and F2 (unstable facet fracture, p:0.03), and one neurologic subtype (N3, p:0.02) exhibited a significant difference in injury severity score. CONCLUSIONS The AO Spine Subaxial Cervical Spine Injury Classification System has shown to be reliable and suitable for proper patient management. The study shows this classification is substantially generalizable by geographic region and surgeon experience; and provides a consistent method of communication among physicians while covering the majority of subaxial cervical spine traumatic injuries.Level of Evidence: 4.

Published
2021

41. Sciodaphyllum pygmaeum Jimenez-Mont. & Idarraga

Author

Jim��nez-Montoya, J��ider, Pizano, Camila, and Id��rraga-Piedrah��ta, ��lvaro

Subjects
Sciodaphyllum, Tracheophyta, Magnoliopsida, Apiales, Biodiversity, Plantae, Araliaceae, Sciodaphyllum pygmaeum, Taxonomy
Abstract

Sciodaphyllum pygmaeum Jim��nez-Mont. & Id��rraga., sp nov. (Figs. 1���2) Type: ��� COLOMBIA. Valle del Cauca. Dagua, Cuenca del R��o Anchicay��, elev. 609 m, 3��34���29.5������ N, 76��52���39.3������ W, 15 September 2018, A . Id��rraga, J. Jim��nez, L. Clavijo & A. Zuluaga 6812 (holotype ICESI!; isotype JAUM!). Diagnosis:��� Sciodaphyllum pygmaeum differs from S. minutiflorum (Harms 1908: 153) Lowry et al. (2019a: 10) by having hollow branches (not solid branches), leaflets 3���5 (not (6���)7���9), poorly reticulate venation abaxially in sicco (not prominent reticulate), stipular ligules (3���) 3.5���6.8 cm long (not 7���13 cm long), tubular (not connation of the margins), glabrous (not tomentulose, glabrescent) and not canaliculated abaxially (canaliculated abaxially), primary axis of the inflorescence 2.2���14.6 cm long (not 15���40 cm long), and secondary axes of inflorescence 5���11 (not 24���66), 4.3���12.2 cm long (not 20���53 cm long). Shrub, 1.2���3.7 m tall, monocaulous, sometimes prostrate, terrestrial or epiphytic, hermaphrodite; branches hollow, slightly lenticellate. Plants glabrous or glabrescent, with a sericeous indument; trichomes up to 0.3 mm long, appressed and whitish. Stipular ligule (3���) 3.5���6.8 cm long, long-triangular, tubular, apex straight to convex, glabrous, without lenticels, not canaliculated abaxially, persistent or caducous. Leaves palmately compound, with 3���5 leaflets, arranged in a single whorl; petioles 30���52 cm long, teretes, slightly thickened at both ends, lenticels absent or few along the petiole; basal petiolules (1���)1.2���2.8(���3.4) cm long, median petiolules (4.7���)7���11.8(���13.3) cm long, teretes, thickened at both ends, canaliculate in sicco; blades 14.4���44 �� 4.5���16 cm, elliptic or occasionally ovate, base acute, convex, occasionally cuneate or rounded, margin entire, apex acute, acuminate, acumen 1.2���2.2(���2.5) cm long, symmetrical or slightly asymmetrical, held horizontally or semi-erect, lustrous on both surfaces. Venation pinnate, prominent on both surfaces; secondary veins 16���30(���33), slightly brochidodromous, prominulous on both surfaces, irregularly spaced; inter-secondary veins present; tertiary veins mixed percurrent, obtuse or perpendicular to the midvein. Inflorescence a panicle, terminal, lilac-magenta; primary axis 2.2���14.6 cm long; with 5���11 secondary axes, 4.3���12.2 cm long, irregularly spaced; the proximal secondary axis bract 1.1���3 cm long, triangular or occasionally deltate, apex acute to obtuse, the other secondary axes bracts 0.8���3 mm long, deltate, apex acute; peduncles 24���64 per axis, (0.6���) 0.8���2.4 mm long, irregularly spaced, usually thickened; ebracteate; ultimate inflorescence units umbels, each 5���9-flowered, the pedicels (0.9���) 1���5.3 mm long; ebracteate. Hypanthium 0.8���1.8 �� 0.8���1.9 mm, densely indumented; calyx rim 5- dentate, teeth 0.34���0.5 mm long; corolla 0.9���1.8 �� 1.5���2 mm, calyptrate, mucronate or not at apex, slightly fissured between petals internally, petals separating 0.3���0.6 mm at base when the calyptra is shed; stamens 5, filaments 1.7���2.5 mm long, whitish-lilac, anthers 0.7���1.1 �� 0.5���0.7 mm, ovate or obovate, reniform in lateral view, sub-dorsifixed insertion, purple, pollen white; disk short-conical, crenulate; 5 styles, 0.35���1.05 mm long, connivets forming a column; ovary 5-carpellate. Fruits drupaceous, 4.7���7.8 �� 4.7���7.3 mm, globose, fleshy; styles recurved; pyrenes 3.2���4.5 �� 2���2.5 mm, laterally flattened. Distribution and habitat: ��� Sciodaphyllum pygmaeum is known from a wet tropical forest (Holdridge 1971) in the basin of the Anchicay�� River in the Choc�� Biogeographical region, in the municipalities of Buenaventura and Dagua in the department of Valle del Cauca in Colombia (Fig. 3), at the elevation of 600��� 770 m. This species is an occasional component of the understory of well-preserved forests of the region. Phenology: ���The specimens collected in September of 2018 presented different phenological states (flower buds, flowers, and fruits). Additional collections and observations made by the Universidad Icesi staff working in the area, recorded flowering between October and December (O. D��az et al. 1821 (ICESI); O. D��az, pers. comm.). Therefore, it appears that the species blooms and fruits throughout the year. Although we were not able to collect extensive data on plant-animal interactions, during field work we saw insects visiting the flowers and birds eating the fruits and seeds. IUCN Red List Category:��� This species can be considered under the category of Least Concern (LC; B1, B2), according to IUCN Red List categories and criteria (IUCN 2012) and using the R packpage ���ConR��� (Dauby 2019; Protected Planet 2019; R Core Team 2019). Based on available data from plant collections, only one population is registered in one single locality, with an extent of occurrence (EOO) and an area of occupancy (AOO) of 4 km 2. These two measurements are the same, because we have so far only found one plant population. However, although the species has low EOO and AOO and is only known from one locality, the studied population grows partially within the conservation area of the Farallones de Cali National Natural Park (IDEAM 2016), which is protected by the Colombian law. Furthermore, the species was found in a largely forested area with no deforestation or other anthropogenic pressures, where we suppose other populations of the species may exist. Due of the reason stated above we consider that the species is at low risk. Etymology: ���The epithet ��� pygmaeum ��� refers to the Latin pygmaeus, meaning dwarf, alluding to the dimensions of the plant and its inflorescence, which are generally smaller when compared with other species in the Minutiflorae group. Additional specimens examined (paratypes): ��� COLOMBIA. Valle del Cauca. Buenaventura, corregimiento El Danubio, Central Hidroel��ctrica Alto Anchicay��, sector La Loca, parcela 2 de 0.1 ha, elev. 767 m, 3��34���38.3������ N, 76��53���03.6������ W, 17 October 2019, O . D��az et al. 1821 (ICESI). Dagua, Cuenca del R��o Anchicay��, elev. 722 m, 3��34���33.8������ N, 76��52���58.2������ W, 15 September 2018, J . Jim��nez et al. 2401 (CUVC, HUA); Cuenca del R��o Anchicay��, elev. 722 m, 3��34���33.8������ N, 76��52���58.2������ W, 15 September 2018, J . Jim��nez et al. 2408 (JAUM, MO); Cuenca del R��o Anchicay��, elev. 722 m, 3��34���33.8������ N, 76��52���58.2������ W, 16 September 2018, J . Jim��nez et al. 2411 (COL, HUA); Cuenca del R��o Anchicay��, elev. 722 m, 3��34���33.8������ N, 76��52���58.2������ W, 17 September 2018, J . Jim��nez et al. 2412 (ICESI, JAUM). Discussion: ���The new species, Sciodaphyllum pygmaeum, is related to species of the informal group Minutiflorae (Plunkett et al. 2005, Frodin et al. 2010). Species in this group are morphologically characterized by being unbranched or occasionally sarmentose shrubs, covered with sericeous, appressed, and whitish indument, that is denser in the hypanthium and very common in the inflorescence axes and the stipular ligule, and the hairs are simple and straight. The leaflets are arranged in a single whorl and are generally glabrous. The inflorescence is a terminal panicle, purplelilac-magenta, generally ebracteate or with small bracts, or rarely with one large proximal secondary axis bract. The terminal inflorescence units are arranged in umbels (rarely heads), and the flowers are pentamerous with a minute dentate calyx, a calyptrate corolla with the petals separating at the base when the calyptra is shed, purple ovate anthers, flat short-conical or concave ovary disc, and free but connivent styles. The fruits are globose with patent styles. This subgroup includes five species, i.e., Sciodaphyllum breviramum (Jim��nez & Id��rraga 2018: 319) Jim��nez & Id��rraga in Lowry et al. (2019a: 7), S. elachistocephalum (Harms 1938: 110) Lowry, Plunkett & Mora in Lowry et al. (2019a: 8), S. magnifolium (Cuatrecasas 1946: 544) Lowry et al. (2019a: 9), S. minutiflorum, and S. sandianum (Harms 1908: 153) Lowry et al. (2019a: 12). Sciodaphyllum pygmaeum differs from the other members of Minutiflorae group by its hollow branches, a tubular stipular ligule, the length of median petiolule (2.5���)4���6(���7.5) times longer than the basal ones, and the fewer number of branches in the inflorescence. Morphologically, S. pygmaeum is most similar to S. minutiflorum, but the dimensions of the plant leaves and inflorescence of S. minutiflorum are larger than those of S. pygmaeum, and the number of leaflets and of the inflorescence branches is also higher in S. minutiflorum, as indicated in the diagnosis. Sciodaphyllum minutiflorum is a species described from Moyobamba in the department of Loreto (Peru), at elevation of 1500���1600 m, and registered in Peru, Ecuador, and Colombia. After a careful examination of the specimens from Colombia, it is concluded that the natural distribution for this species in the country is across the Andean Cordillera region at elevation of 1400���2500 m, in premontane wet forest (bh-PM), premontane moist forest (bmh-PM), wet low montane forest (bh-MB), and moist low montane forest (bmh-MB; Holdridge 1971)., Published as part of Jim��nez-Montoya, J��ider, Pizano, Camila & Id��rraga-Piedrah��ta, ��lvaro, 2021, A new species of Sciodaphyllum (Araliaceae) from the Choc�� Biogeographical region in Colombia, pp. 184-190 in Phytotaxa 491 (2) on pages 184-188, DOI: 10.11646/phytotaxa.491.2.8, http://zenodo.org/record/5755478, {"references":["Harms, H. (1908) Araliaceae Peruvianae. Botanische Jahrbucher fur Systematik, Pflanzengeschichte und Pflanzengeographie 42: 148 - 162.","Lowry II, P. P., Plunkett, G. M., Mora, M. M., Cano, A., Fiaschi, P., Idarraga-Piedrahita, A., Jimenez-Montoya, J., Mendoza, M., Neill, D. A., Rivera-Diaz, O. & Rodrigues-Vaz, C. (2019 a) Studies in Neotropical Araliaceae. I. Resurrection of the genus Sciodaphyllum P. Browne to accommodate most New World species previously included in Schefflera J. R. Forst. & G. Forst. Brittonia 72: 1 - 15. https: // doi. org / 10.1007 / s 12228 - 019 - 09593 - w","Holdridge, L. R. (1971) Life Zone Ecology. Tropical Science Center. San Jose, Costa Rica. 149 pp.","IUCN. (2012) IUCN Red List Categories and Criteria: version 3.1. ed. 2. Gland & Cambridge U. K. Available at: http: // www. iucnredlist. org / (accessed 20 June 2020)","Dauby, G. (2019) ConR: Computation of parameters used in preliminary assessment of conservation Status. R package version 1.2. 4. Available at: https: // CRAN. R-project. org / package = ConR (accessed 20 September 2020)","Protected Planet. (2019) The World Data Base on Protected Areas. Publisher, location. Available at: https: // www. protectedplanet. net / (accessed 18 September 2020)","R Core Team. (2019) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Available at: https: // www. R-project. org / (accessed 18 September 2020)","IDEAM. (2016) Mapa de Bosque / No Bosque Colombia- area Continental (Escala Fina LANDSAT). IDEAM, Bogota. Available at: http: // www. ideam. gov. co / web / ecosistemas / superficie-cubierta-por-bosque-natural (accessed 15 June 2020)","Plunkett, G. M., Lowry II, P. P., Frodin, D. G. & Wen, J. (2005) Phylogeny and Geography of Schefflera: pervasive polyphyly in the largest genus of Araliaceae. Annals of the Missouri Botanical Garden 92: 202 - 224.","Frodin D. G., Lowry II, P. P. & Plunkett, G. M. (2010) Schefflera (Araliaceae): taxonomic history, overview and progress. Plant Diversity and Evolution 128: 561 - 595. https: // doi. org / 10.1127 / 1869 - 6155 / 2010 / 0128 - 0028","Harms, H. (1938) Eine neue Araliacee aus Colombia (Schefflera elachistocephala). Repertorium Specierum Novarum Regni Vegetabilis 43: 110. https: // doi. org / 10.1002 / fedr. 4870430111","Cuatrecasas, J. (1946) Notas a la Flora de Colombia VIII. Araliaceae. Revista de la Academia Colombiana de Ciencias Exactas, Fisicas y Naturales. 6: 533 - 547."]}

Published
2021
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42. The Genetic Landscape of Mitochondrial Diseases in Spain: A Nationwide Call

Author

Bellusci M, Paredes-Fuentes AJ, Ruiz-Pesini E, Gómez B, Martín MA, Montoya J, and Artuch-Iriberri R

Subjects
mitochondrial diseases, epidemiological data, incidence, nuclear DNA mutations, Spanish registry, mitochondrial DNA mutations
Abstract

The frequency of mitochondrial diseases (MD) has been scarcely documented, and only a few studies have reported data in certain specific geographical areas. In this study, we arranged a nationwide call in Spain to obtain a global estimate of the number of cases. A total of 3274 cases from 49 Spanish provinces were reported by 39 centres. Excluding duplicated and unsolved cases, 2761 patients harbouring pathogenic mutations in 140 genes were recruited between 1990 and 2020. A total of 508 patients exhibited mutations in nuclear DNA genes (75% paediatric patients) and 1105 in mitochondrial DNA genes (33% paediatric patients). A further 1148 cases harboured mutations in the MT-RNR1 gene (56% paediatric patients). The number of reported cases secondary to nuclear DNA mutations increased in 2014, owing to the implementation of next-generation sequencing technologies. Between 2014 and 2020, excepting MT-RNR1 cases, the incidence was 6.34 (95% CI: 5.71-6.97) cases per million inhabitants at the paediatric age and 1.36 (95% CI: 1.22-1.50) for adults. In conclusion, this is the first study to report nationwide epidemiological data for MD in Spain. The lack of identification of a remarkable number of mitochondrial genes necessitates the systematic application of high-throughput technologies in the routine diagnosis of MD.

Published
2021

43. Alzemon: a prospective follow-up study of eslicarbazepine acetate monotherapy in patients with newly diagnosed epilepsy

Author

Hernández-Rubio L, Asensio-Asensio M, Tortosa-Conesa D, Alfaro-Sáez A, García-Escrivá A, Díaz-Román M, Montoya J, Méndez-Miralles MA, Bertol-Alegre V, Castro-Vilanova MD, Galiano ML, Blanco-Cantó ME, and López-González F

Subjects
Adult, Male, Epilepsy, Antiepileptic drugs, Middle Aged, Eslicarbazepine acetate, Monotherapy, Dibenzazepines, Humans, Adults, Anticonvulsants, Female, Partial epilepsy, Prospective Studies, Prospective study, Aged, Follow-Up Studies
Abstract

Eslicarbazepine acetate is a novel sodium channel blocker for use in the treatment of focal onset seizures. Prospective studies on its effectiveness in monotherapy in patients with newly diagnosed partial epilepsy in routine clinical practice are scarce.To evaluate the effectiveness of eslicarbazepine as initial monotherapy in patients with newly diagnosed partial epilepsy in routine clinical practice.A prospective, multicentre, post-authorisation study. Patients with newly diagnosed partial epilepsy aged 18 years or older without previous treatment were included. The efficacy variables were: percentage of seizure-free patients, responders and reduction in monthly frequency of seizures. The safety variables analyse the 12-month retention rate and the occurrence of adverse effects.Fifty-three patients were included. The retention rate was 77.4%. At the end of the observation period, 83% of patients were seizure-free and 92.5% had reduced their baseline frequency by 50% or more. In addition, 68% of the patients reported some adverse effect and 7.5% of them dropped out of the study for this reason. The effectiveness analysis of the subgroup of patients aged 65 years or more showed no differences with respect to the overall population.Eslicarbazepine monotherapy in patients with newly diagnosed partial epilepsy, both in the general population and in the population over 65 years old, is effective and safe in routine clinical practice.Alzemon: estudio de seguimiento prospectivo del acetato de eslicarbacepina en monoterapia en pacientes con epilepsia de diagnóstico reciente.Introducción. El acetato de eslicarbacepina es un nuevo bloqueante de los canales de sodio en el tratamiento de las crisis de inicio focal. Los estudios prospectivos sobre su efectividad en monoterapia en pacientes con epilepsia parcial de reciente diagnóstico en la práctica clínica habitual son escasos. Objetivo. Evaluar la efectividad de la eslicarbacepina en monoterapia de inicio en pacientes con epilepsia parcial de reciente diagnóstico en la práctica clínica habitual. Pacientes y métodos. Estudio postautorización prospectivo y multicéntrico. Se incluyó a pacientes con epilepsia parcial de reciente diagnóstico de 18 años o más sin tratamiento previo. Las variables de eficacia fueron: porcentaje de pacientes libres de crisis, respondedores y reducción en la frecuencia mensual de crisis. Las variables de seguridad analizan la tasa de retención a los 12 meses y la aparición de efectos adversos. Resultados. Se incluyó a 53 pacientes. La tasa de retención fue del 77,4%. Al final del período de observación, el 83% de los pacientes se encontraba libre de crisis y el 92,5% había reducido en un 50% o más su frecuencia basal. El 68% de los pacientes notificó algún efecto adverso y el 7,5% de ellos abandonó el estudio por este motivo. El análisis de efectividad del subgrupo de 65 años o más no mostró diferencias respecto a la población global. Conclusión. La eslicarbacepina en monoterapia en pacientes con epilepsia parcial de reciente diagnóstico, tanto en la población general como en la población de más de 65 años, es eficaz y segura en la práctica clínica habitual.

Published
2021

45. High Prevalence of Huntington’s Disease in CañetePerú

Author

Mazzetti P, Marca M, Micheli F, Montoya J, Domínguez J, Torres L, Mendoza H, Mendoza, Thioub M, Ortega O, Pérez D, and Mori N

Subjects
Pediatrics, medicine.medical_specialty, High prevalence, Huntington's disease, business.industry, medicine, business, medicine.disease, Buprenorphine, medicine.drug, Methadone
Published
2020

49. SEROPREVALENCE OF ANTIBODIES AGAINST MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS AND ITS RELATIONSHIP TO AGE AND SEX OF TEXAS WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) IN COAHUILA, MEXICO

Author

Lozano-Cavazos, E. Alejandro, primary, Velázquez-Morales, J. Vicente, additional, Santillán-Flores, Marco A., additional, Tarango-Arámbula, Luis A., additional, Olmos-Oropeza, Genaro, additional, Martínez-Montoya, J. Felipe, additional, and Cortez-Romero, César, additional

Published
2021
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