473 results on '"Montes, R."'
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2. Transgenerational inheritance of chemical-induced signature: A case study with simvastatin
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Neuparth, T., Machado, A.M., Montes, R., Rodil, R., Barros, S., Alves, N., Ruivo, R., Castro, L. Filipe C., Quintana, J.B., and Santos, M.M.
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- 2020
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3. CONSTITUTIONALIZING THE HUMAN RIGHT TO FOOD IN MAINE: A PEOPLE'S TOOL TO ADVANCE FOOD SOVEREIGNTY IN THE UNITED STATES.
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Córdova Montes, R. Denisse, Retberg, Heather, and Suarez, Photini Kamvisseli
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On November 2, 2021, Maine voters overwhelmingly supported a statewide referendum approving an amendment to enshrine the right to food in Maine's constitution. This vote was preceded by a decade of food sovereignty advocacy in Maine. This advocacy was led by small farmers and homesteaders and supported by people looking to opt out of the industrial food system, which is dominated by a few corporate monopolies and promotes charity-based solutions to hunger. This vote was a resounding proclamation by the people of Maine in support of the right to food, the right to save and exchange seeds, and the right to grow, raise, harvest, produce, and consume the food of their own choosing for their own nourishment, sustenance, bodily health, and well-being. Maine's efforts are connected to a wider national and international community of smallholder farmers--or peasants--and people living and working in rural areas, food system workers, and people experiencing hunger and food insecurity. Although Maine is the first U.S. state to enshrine the right to food in its constitution, international human rights law firmly recognizes a right to adequate food. The International Covenant on Economic, Social and Cultural Rights upholds "the right of everyone to an adequate standard of living for himself and his family, including adequate food, clothing, and housing, and to the continuous improvement of living conditions." The right is further enumerated in international law through additional conventions and standards and is continuously being interpreted and analyzed by United Nations expert bodies. Moreover, the groundbreaking adoption of the U.N. Declaration on the Rights of Peasants and Other People Working in Rural Areas, after seventeen years of global mobilization and negotiations by peasant movements, led to the international recognition of their rights. These include the rights to food sovereignty and individual and collective access to natural resources, including land, water, and seeds. This Article examines Maine's constitutional amendment on the right to food by looking at its food sovereignty origins and relying on international human rights law. This analysis reflects on how Maine's right to food could serve as an antidote for the privatization of water and natural resources and pave the road for people to regain access to land and water, reclaim native seeds, restore biodiversity, and promote sustainability and autonomy in a localized food system. Drawing on their involvement in a growing right to food movement in the United States that is made up of small farmers, legislators, advocates, academics, and people with lived experiences of hunger, the authors also reflect on opportunities to translate Maine's experience to other states with ongoing legislative and organizing efforts focused on the human right to food. [ABSTRACT FROM AUTHOR]
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- 2024
4. NOMINAL TENSE IN TIKUNA (YURI-TIKUNA)/TIEMPO NOMINAL EN TIKUNA (YURI-TIKUNA)/TEMPO NOMINAL EM TIKUNA (YURI-TIKUNA)
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Montes R., Maria Emilia
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- 2019
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5. The Nature of Savanna Heterogeneity in the Orinoco Basin
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San Jose, J. J., Montes, R., and Mazorra, M.
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- 1998
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6. Letter to the editor regarding Collard et al. (2023): “Persistence and mobility (defined as organic-carbon partitioning) do not correlate to the detection of substances found in surface and groundwater: Criticism of the regulatory concept of persistent and mobile substances”
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Arp, H.P.H., Wolf, R., Hale, S.E., Baskaran, S., Glüge, J., Scheringer, M., Trier, X., Cousins, I.T., Timmer, H., Hofman-Caris, R., Lennquist, A., Bannink, A.D., Stroomberg, G.J., Sjerps, R.M.A., Montes, R., Rodil, R., Quintana, J.B., Zahn, Daniel, Gallard, H., Mohr, T., Schliebner, I., Neumann, M., Arp, H.P.H., Wolf, R., Hale, S.E., Baskaran, S., Glüge, J., Scheringer, M., Trier, X., Cousins, I.T., Timmer, H., Hofman-Caris, R., Lennquist, A., Bannink, A.D., Stroomberg, G.J., Sjerps, R.M.A., Montes, R., Rodil, R., Quintana, J.B., Zahn, Daniel, Gallard, H., Mohr, T., Schliebner, I., and Neumann, M.
- Abstract
no abstract
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- 2023
7. A new analytical method to determine trace level concentrations of pharmaceuticals in influent wastewater: A tool to monitor human use patterns
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Universitat Rovira i Virgili, Fontanals N; Pocurull E; Montes R; González-Mariño I; Santana-Viera S; Miró M; Rico A; Rodríguez-Mozaz S; Borrull F; Benito Quintana J; Maria Marcé R, Universitat Rovira i Virgili, and Fontanals N; Pocurull E; Montes R; González-Mariño I; Santana-Viera S; Miró M; Rico A; Rodríguez-Mozaz S; Borrull F; Benito Quintana J; Maria Marcé R
- Abstract
The occurrence of pharmaceuticals in influent wastewater samples (IWW) is a recurrent issue. The monitoring of their presence is not only valuable from an environmental point of view, but also as a tool to analyze patterns of human use by the so-called wastewater-based epidemiology. The development of an analytical method based on solid-phase extraction followed by liquid chromatography coupled to tandem mass spectrometry to monitor the occurrence of a group of seventeen pharmaceuticals including the most representative for various therapeutic families in IWW samples is described in this work. The samples were collected during a monitoring week in six wastewater treatment plants located in different cities and towns across Spain. The developed method provides acceptable figures of merit with apparent recoveries in IWW ranging from 42% to 139%, and low matrix effect (in general lower than ± 30%), and method quantification limits (MQL) between 1 ng/L and 24 ng/L for all compounds, except atenolol (58 ng/L). All the studied pharmaceuticals were found in all samples with concentrations ranging from < MQL to 10,393 ng/L, being the highest concentrations for tramadol. The population normalized daily loads revealed that the use of pharmaceuticals follows, in general, a similar pattern in all cities monitored.
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- 2023
8. Tiempo nominal en tikuna (Yurí-Tikuna)
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María Emilia Montes R.
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tikunas ,Amazonas ,Colombia ,morfología ,sintaxis ,tam nominal ,Language and Literature ,Philology. Linguistics ,P1-1091 - Abstract
En tikuna el paradigma tripartito de femenino, masculino y pasado es un paradigma de clase nominal altamente gramaticalizado, concordante y de ineludible expresión en una serie de contextos gramaticales. La fusión del paradigma de género y de tiempo es un fenómeno relativamente original del tikuna. Los nominales expresan solo las categorías de ‘pasado’ y de ‘no pasado’, a diferencia de lo que ocurre en lenguas en las cuales hay también marcadores para tiempo nominal futuro o para pasado remoto. Tipológicamente el tikuna pertenecería al grupo en el que el tiempo nominal tiene alcance proposicional. Estas categorías nominales, además, se extienden a algunos conectores discursivos, otro comportamiento parcialmente original de esta lengua. En el género narrativo se atestigua ampliamente la presencia de estas formas con valor temporal y modalizador.
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- 2019
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9. Studies on the formation of polymeric nano-emulsions obtained via low-energy emulsification and their use as templates for drug delivery nanoparticle dispersions
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Calderó, G., Montes, R., Llinàs, M., García-Celma, M.J., Porras, M., and Solans, C.
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- 2016
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10. Highly sensitive electrochemical immunosensor for IgG detection based on optimized rigid biocomposites
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Montes, R., Céspedes, F., and Baeza, M.
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- 2016
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11. A web tool to support decision making in the housing market using hesitant fuzzy linguistic term sets
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Montes, R., Sánchez, A.M., Villar, P., and Herrera, F.
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- 2015
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12. Group V secretory phospholipase A2 impairs endothelial protein C receptor‐dependent protein C activation and accelerates thrombosis in vivo
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Tamayo, I., Velasco, S.E., Puy, C., Esmon, C.T., Dichiara, M.G., Montes, R., and Hermida, J.
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- 2014
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13. DESCRIPCIÓN MORFOLÓGICA DE Bromelia karatas RECURSO GENÉTICO PROMISORIO PARA PATÍA, CAUCA, COLOMBIA
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CONSUELO MONTES R, VÍCTOR FELIPE TERÁN G, RUSBEL ARMANDO ZUÑIGA B, and YUDY ELIZABETH CALDÓN P.N
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Descripción botánica ,Bromeliaceaea ,Plantas silvestres ,Agriculture (General) ,S1-972 ,Biotechnology ,TP248.13-248.65 - Abstract
La presente investigación se realizó en el Departamento del Cauca, Municipio del Patía, Corregimiento El Puro, Vereda El Puro, donde se trabajó con el grupo Cooperativa Multiactiva de Mujeres Emprendedoras del Puro, Patía. El objetivo del trabajo fue realizar la descripción morfológica de la planta de piñuela Bromelia karatas paracontribuir al conocimiento de la especie y ayudar a definir caracteres de selección para la recuperación y aprovechamiento de la misma. La descripción morfológica de la planta de piñuela, se realizó mediante observación en campo de plantas en cercas vivas y su posterior análisis en laboratorio. Los resultados mostraron que la planta de Bromelia karatas, se caracteriza por ser acaule, poseer raíz homorricia, tallo inconspicuo, hoja lanceolada y arrosetadas, inflorescencia sésil y fruto fusiforme, agridulce y jugoso.
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- 2014
14. Patterns of Medication Use in Systemic Lupus Erythematosus: A Multicenter Cohort Study
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Kandane-Rathnayake, R, Louthrenoo, W, Luo, S-F, Wu, Y-JJ, Chen, Y-H, Golder, V, Lateef, A, Cho, J, Navarra, S, Zamora, L, Hamijoyo, L, Sockalingam, S, An, Y, Li, Z, Montes, R, Oon, S, Katsumata, Y, Harigai, M, Hao, Y, Zhang, Z, Chan, M, Kikuchi, J, Takeuchi, T, Goldblatt, F, O'Neill, S, Bae, S-C, Lau, CS, Hoi, A, Karyekar, CS, Nikpour, M, Morand, EF, Kandane-Rathnayake, R, Louthrenoo, W, Luo, S-F, Wu, Y-JJ, Chen, Y-H, Golder, V, Lateef, A, Cho, J, Navarra, S, Zamora, L, Hamijoyo, L, Sockalingam, S, An, Y, Li, Z, Montes, R, Oon, S, Katsumata, Y, Harigai, M, Hao, Y, Zhang, Z, Chan, M, Kikuchi, J, Takeuchi, T, Goldblatt, F, O'Neill, S, Bae, S-C, Lau, CS, Hoi, A, Karyekar, CS, Nikpour, M, and Morand, EF
- Abstract
OBJECTIVE: Evidence for the utility of medications in settings lacking randomized trial data can come from studies of treatment persistence. The present study was undertaken to examine patterns of medication use in systemic lupus erythematosus (SLE) using data from a large multicenter longitudinal cohort. METHODS: Prospectively collected data from the Asia Pacific Lupus Collaboration cohort including disease activity (SLE Disease Activity Index 2000 [SLEDAI-2K]) and medication details, captured at every visit from 2013-2018, were used. Medications were categorized as glucocorticoids (GCs), antimalarials (AM), and immunosuppressants (IS). Cox regression analyses were performed to determine the time-to-discontinuation of medications, stratified by SLE disease activity. RESULTS: Data from 19,804 visits of 2,860 patients were analyzed. Eight medication categories were observed: no treatment; GC, AM, or IS only; GC plus AM; GC plus IS; AM plus IS; and GC plus AM plus IS (triple therapy). Triple therapy was the most frequent pattern (31.4% of visits); single agents were used in 21% of visits, and biologics in only 3%. Time-to-discontinuation analysis indicated that medication persistence varied widely, with the highest treatment persistence for AM and lowest for IS. Patients with a time-adjusted mean SLEDAI-2K score of ≥10 had lower discontinuation of GCs and higher discontinuation of IS. CONCLUSION: Most patients received combination treatment. GC persistence was high, while IS persistence was low. Patients with high disease activity received more medication combinations but had reduced IS persistence, consistent with limited utility. These data confirm unmet need for improved SLE treatments.
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- 2022
15. CONSUMO DE ALCOHOL EN ESPAÑA SEGÚN SUS AGUAS RESIDUALES
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López de Alda, Miren, Bonansea, Rocío Inés, Bobrisev, V., Quintana, J.B., Montes, R., González-Mariño, I., Marcé, R.M., Bijlsma, L., Picó, Yolanda, López de Alda, Miren, Bonansea, Rocío Inés, Bobrisev, V., Quintana, J.B., Montes, R., González-Mariño, I., Marcé, R.M., Bijlsma, L., and Picó, Yolanda
- Abstract
El análisis de aguas residuales como medio para investigar la salud pública y el estilo de vida está ganando cada vez más aceptación y aplicación en todo el mundo.
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- 2022
16. EFECTO INSECTICIDA DEL EXTRACTO DE Bocconia frutescens L. SOBRE LARVAS DE CHISAS
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CONSUELO MONTES R, CLAUDIA SOFÍA PEÑA C, and VIVIANA GUTIÉRREZ H
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Extracto vegetal ,Ancognatha vulgaris ,fresa ,Porcentaje de infestación ,Porcentaje de intensidad de infestación ,Agriculture (General) ,S1-972 ,Biotechnology ,TP248.13-248.65 - Abstract
Esta investigación se realizó en el municipio de Puracé Cauca, para evaluar el efecto insecticida del extracto de Bocconia frutescens sobre larvas de chisa Ancognatha vulgaris. Se empleo un diseño de bloques completos al azar, con cinco tratamientos y tres repeticiones. Los tratamiento T1, T2 y T3 corresponden a concentraciones de 14%, 17% y 20 % del extracto de zarcillejo, T4 tratamiento químico (Carbofuran) y T5 Testigo. Las variables evaluadas fueron: presencia de larvas de chisas sanas y larvas afectadas, daño en plantas, evaluado como intensidad y porcentaje de infestación. Se presentaron diferencias significativas para las variables: intensidad e infestación, larvas de chisas sanas y afectadas-muertas, en diferentes días de evaluación. El mejor tratamiento fue el T2, seguido por T3 y T1. Para el porcentaje de daño causado a la planta los mejores tratamientos fueron T2 y T5 con 57% para intensidad y para infestación 55% y 45% en T2 y T3. El análisis fitoquímico mostró la presencia de alcaloides, terpenos, antronas y cumarinas en el extracto. El efecto causado por el extracto sobre las larvas fue deshidratación y flacidez hasta provocar la muerte, lo cual se atribuyea la acción de alguno de sus metabòlitos o la combinación de varios.
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- 2013
17. Ionospheric disturbances detected by MEXART
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Carrillo-Vargas, A., Pérez-Enríquez, R., Rodríguez-Martínez, Mario, López-Montes, R., Casillas-Pérez, G.A., and Araujo-Pradere, E.A.
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- 2012
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18. Activated prothrombin complex concentrate to treat bleeding events in acquired hemophilia A: BAHAS study
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Mingot-Castellano ME, García-Candel F, Benítez-Hidalgo O, Marco A, Méndez Navarro GA, Pérez-Montes R, García Donas G, Canaro M, Paloma MJ, Asenjo B, Calle-Gordo VM, González NP, Rodríguez González R, Caparrón-Miranda IS, Quintana París L, Herrero S, and Nuñez R
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coagulation disorders ,inhibitors ,bypass agent ,prophylaxis ,acquired hemophilia ,bleeding - Abstract
OBJECTIVE: Activated prothrombin complex concentrate (aPCC) is a bypassing agent indicated to treat bleeds in patients with acquired hemophilia A (AHA). Nevertheless, its efficacy and safety in the real-world setting have not often been addressed. METHODS: We report the experience of Spanish reference centers for coagulation disorders and from acquired hemophilia Spanish Registry (AHASR) from August 2012 to February 2021. Follow-up period of 30 days after aPCC withdrawal. RESULTS: Thirty patients with a median age of 70 years old, suffering from 51 bleeds treated with aPCC were finally evaluated. As first-line treatment, aPCC stopped bleeding in 13 of 14 (92.9%) cases. aPCC as the second line after recombinant factor VIIa failure, stopped bleeding in all cases. In 17 patients, aPCC was used far from initial bleed control as prophylaxis of rebleeding with 94% effectiveness. No thromboembolic episodes were communicated. One patient developed hypofibrinogenemia, which did not prevent aPCC from halting bleeding. No other serious adverse events possibly or probably associated with aPCC were reported. CONCLUSIONS: This data support aPCC as hemostatic treatment in AHA with high effectiveness and excellent safety profile in acute bleeds and as extended use to prevent rebleedings, even in aging people with high cardiovascular risk.
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- 2022
19. INFESTACIÓN E INCIDENCIA DE BROCA, ROYA Y MANCHA DE HIERRO EN CULTIVO DE CAFÉ DEL DEPARTAMENTO DEL CAUCA ESTUDO DE INFESTAÇÃO E INCIDÊNCIA DA BROCA, A FERRUGEM E A CERCOSPOREOSE O CULTIVO DO CAFÉ NO DEPARTAMENTO DO CAUCA INFESTATION AND INCIDENCE STUDY OF THE COFFEE BORER, COFFEE RUST AND IRON SPOT DISEASE ON THE COFFEE CROP IN CAUCA DEPARTMENT
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CONSUELO MONTES R., OSCAR ARMANDO PATIÑO, and ROBERTO AMILCAR CADENA
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Enfermedades de las plantas ,Cultivos ,Epidemiología ,Doenças das plantas ,Epidemiologia ,Plant diseases ,Pests ,Epidemiology ,Agriculture (General) ,S1-972 ,Biotechnology ,TP248.13-248.65 - Abstract
El estudio de incidencia e infestación de plagas limitantes para café como Roya (Hemileia vastatrix), Broca (Hypothenemus hampei), y Mancha de hierro (Cercospora coffeicola), se desarrolló entre marzo de 2006 y Diciembre de 2007 en cuatro municipios con ocho predios sensores. Se realizaron muestreos mensuales para incidencia e infestación de cada plaga. Se siguió la metodología propuesta por CENICAFÉ, 30 árboles/ha para evaluar infestación de Broca e incidencia de la Mancha de hierro y 10 para incidencia de Roya. Se registro temperatura, precipitación, humedad relativa y brillo solar para relacionar el comportamiento de las plagas con el clima. La incidencia e infestación superaron significativamente el umbral de daño económico (5%) para cada plaga. El promedio de incidencia fue de 14,7% para Roya y 4,8% para Mancha de hierro, el de infestación para Broca fue de 4,7%. La temperatura y precipitación presentaron gran relación con la dinámica epidemiológica de las plagas. Altas temperaturas están relacionadas con alta incidencia e infestación de Roya y Broca, principalmente entre junio y septiembre, contrariamente a la Mancha de hierro que estuvo relacionada con alta precipitación, principalmente entre marzo y mayo. Estos resultados alertan acerca de la presencia de estas plagas en los cultivos de la región.No departamento do Cauca foi realizado um estudo epidemiologico de três pragas limitantes na produção de café (Coffea arabica): a ferrugem produzida pelo fungo Hemileia vastatrix, a Broca do café produzida pelo inseto Hypothenemus hampei, e a cercosporiose produzida pelo fungo Cercospora coffeicola. O estudo foi feito nos anos 2006 e 2007 em quatro municipios onde foram escolhidos 8 fazendas nas que foram realizadas amostragens para obter a percentagem de apresentação das doenças. As amostragens foram feitas segundo a metodología proposta pelo CENICAFE. Trinta arbores por hectare foram avaliados para determinar a precença de Broca e a cercosporiose, e dez para avaliar a presença de ferrugem. Foram registrados os valores de temperatura, precipitação, humidade, e brilho solar objetivando determinar a relação entre o clima e a presença de doenças. O nivel máximo aceitável de infestação na plantação é do 5%. O promedio de infestação no periodo avaliado foi de 14,7% para a ferrugem, 4,7% para a Broca e 4,8 para a cercosporiose. Temperatura e precipitação foram as que apresentaram maior relação com a presença das doenças. Altas temperaturas estão relacionadas com maior apresentação de ferrugem e Broca, principalmente nos meses de junhio e setembro, pelo contrario, a cercosporiose, altamente correlacionada com a presença de chuvas, ocorre principalmente nos meses de marzo e maio. Estes resultados alertan sobre a presença destas pragas nas plantações da região.The epidemiological study was carried out on three Colombian coffee production limiting pests, i.e. Coffee borer (Hypothenemus hampei Ferrari), Coffee rust (Hemileia vastatrix) and Iron spot disease (Cercospora coffeicola) of four municipalities of the Cauca department. Eight sensoring localities were selected and sampled monthly in order to obtain the infestation and incidence of each pest during 2006 and 2007(from March and December). Sampling was done according to the process established by Cenicafé, 30 Coffee shrubs were taken for the Coffee borer and the Iron spot disease evaluation, and 10 for coffee rust evaluation per hectare respectively, the corresponding infestation and incidence percentages were obtained by grain and leaves counting. Temperature, precipitation, relative humidity and solar bright data were obtained from neighboring climatological stations, in order to relate the pests behavior with climate. The plagues infestation and incidence in most cases exceeded the 5% economical damage threshold; the mean incidence and infestation during the evaluation period was 14,7% for Rust, 4,7% for Coffee borer and 4,8% on Iron spot disease. The temperature and precipitation variables were the ones which exhibited closer relationship with the plagues epidemiological dynamics. High temperatures are related to high Coffee borer and Rust incidence, mainly between June and September, contrary to the Iron spot disease, which was related to high precipitations, mainly between March and May. The results give en alert concerning plagues presence on the regional crops.
- Published
- 2012
20. VALORACIÓN DE LA CIDRA PAPA (Sechium edule) COMO ALTERNATIVA DE ALIMENTACIÓN Y RECUPERACIÓN DE VÍNCULOS CON EL CAMPO VALORAÇÃO DA Sechium edule COMO ALTERNATIVA DE ALIMENTAÇÃO E RECUPERAÇÃO DOS VINCULOS COM O CAMPO VALUATION OF Sechium edule AS AN ALIMENTARY ALTERNATIVE AND RECUPERATION OF BONDS TO THE COUNTRY
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CONSUELO MONTES R and ASTRID ALEJANDRA GÓMEZ G
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Sechium edule ,recurso genético ,ecotipos ,ecótipos ,genetics resources ,ecotypes ,Agriculture (General) ,S1-972 ,Biotechnology ,TP248.13-248.65 - Abstract
El objetivo de la investigación, fue valorar la cidra papa (Sechium edule) como alternativa de alimentación para familias en desplazamiento que viven en asentamientos urbano marginales de Popayán, con el fin de contribuir a la recuperación del conocimiento tradicional asociado al uso y manejo, identificar ecotipos, identificar el significado sociocultural como alternativa para mantener los vínculos con el campo, evaluar productividad y posibilidades de manejo en espacios urbano marginales. El proceso se desarrolló mediante 'investigación participativa', donde los actores participaron en dinámicas recreativas, talleres de sensibilización y socialización, giras de intercambio de saberes, de semillas y generación de conocimientos, lo que permitió obtener información, y la apropiación del proceso. Se definieron como áreas de estudio 3 comunas de Popayán, se seleccionaron 4 asentamientos, se aplicaron 116 encuestas, se realizaron visitas mensuales por asentamiento, entablando diálogos informales con las familias participantes. Se conocieron las posibilidades de manejo de la planta, se incentivó la siembra de la misma aplicando el concepto de agricultura urbana donde se asoció la planta con otras hortalizas. Se pudo constatar que plantas como la cidra se adaptan a las condiciones que ofrecen los asentamientos y que son fuente alternativa para la alimentación de estas poblaciones, se fomentó el consumo de especies sub utilizadas, se hizo intercambio de saberes y se generaron espacios para motivar la conservación de ecotipos y especies de plantas como la cidra, que pueden resistir a las condiciones de marginalidad.0 objetivo da pesquisa, foi avaliar a cidra papa (Sechium edule) como alternativa de alimentação para familias deslocadas que moram nos perímetros da cidade de Popayán, com o proposito de contribuir na recuperação do conhecimento tradicional relacionado com a utilização e manejo, identificação de ecotipos e o significado cultural como alternativa para manter os vínculos como o campo, avaliara a produtividade y possibilidades de manejo na periferia da área urbana. 0 processo foi feito atraves da 'pesquisa participativa', onde os atores participaram de jogos y atividades para crear conciência que permitiram obter informação e apropiação do processo. Foram definidas como áreas de estudo 3 comunidades de Popayán, escolhidos 4 asentamentos, aplicadas 116 encuestas, visitas mensuales por asentamento, maniendo dialogos com as familias participantes. Foram conhecidas as possibilidades de manejo da planta, motivada sua semeadura aplicando o conceito de agricultura urbana. Foi possível determinar que a cidra adapta-se as condições que oferecem os asentamentos e que são fontes alternativas de alimento para estas populações, foi motivado o consumo desta especie subutilizada. Diferentes conhecimentos foram intercambiados sobre a utilização desta especie y seu cultivo en condições marginais.The research target was to value Sechium edule as a nutrition alternative for displaced families living in Popayán's marginal urban settlements, aiming to contribute to the traditional knowledge recuperation associated it's use and management, to identify the sociocultural significance as an alternative to mantain the links with the country, to evaluate the productivity and management possibilities in urban marginal areas. The process was carried out by means of 'participative investigation' where actors participated on recreative dynamics, sensibilization and socialization workshops, knowledge generating and exchanging tours which also served for exchanging seeds, permitting to obtain information and empowerment with the process. Three communities of Popayan were defined as study areas, four settlements were selected and 116 interviews made. The settlements were visited monthly for informal dialogues with the participating families. The plant's management possibilities were studied and it's cultivation under an urban cultivation scheme in association with other orchard species incentivated. The adptation of the system under the settlement's condition was asessed as a an alimentary alternative for these population. The consumption of sub-utilized species and the ecotype's conservation were encouraged.
- Published
- 2011
21. Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells
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Montes, R, Ayllón, V, Prieto, C, Bursen, A, Prelle, C, Romero-Moya, D, Real, P J, Navarro-Montero, O, Chillón, C, Marschalek, R, Bueno, C, and Menendez, P
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- 2014
- Full Text
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22. The role of coagulation disorders in patients with retinal vein occlusion
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Napal, J.J., Neila, S., Pérez-Montes, R., Sierra, I., Ruiz, S., and Hernández, J.L.
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- 2016
- Full Text
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23. Pharmacogenetics of acenocoumarol in patients with extreme dose requirements
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PÉREZ-ANDREU, V., ROLDÁN, V., LÓPEZ-FERNÁNDEZ, M.F., ANTÓN, A.I., ALBERCA, I., CORRAL, J., MONTES, R., GARCÍA-BARBERÁ, N., FERRANDO, F., VICENTE, V., and GONZÁLEZ-CONEJERO, R.
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- 2010
- Full Text
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24. Cost-Effective Comparison Between Two Anesthesia Techniques: Sevofluorane-Remifentanyl vs Isofluorane-Remifentanyl
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Marco A. Carvajal C., Ismael Rincón F, and Félix Montes R.
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Pharmaceutical economic ,costbenefit analysi ,anesthesi ,costs ,Medicine ,Medicine (General) ,R5-920 - Abstract
We are in the of costs optimization era, reasonwhy it is necessary to make pharmaceuticaleconomics studies to identify the costeffectivenessof today’s anesthetics. Methods: thisprospective study, blinded to the patient,compared the direct costs, recovery times andsatisfaction of 45 patients randomly assigned totwo balanced anesthesia groups (sevofluoraneremifentanilgroup n = 24 or isofluoraneremifentanilgroup n = 21) submitted tootorhinolaringology surgical procedures.Results: the times of early recovery (ocularopening, answer to commandos, extubación,orientation and room leave) were smaller in ISOgroup and had statistically significant difference. Variable data was found in acquisition costs ofhalogenados gastados, lesser for isofluorane,which also made the anesthetic supplies lessexpensive during surgical procedures; nevertheless,costs in the delivery room, in recoveryand ambulatory room, and the total costs did notshow significant differences. Satisfaction was similarbetween both groups. Conclusions: asevofluorane-remifentanil based technique is notmore cost-effective than to use isofluoraneremifentanilfor ambulartory patients submittedto otorhinolaringology surgical procedures
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- 2005
25. Diversidad genética de germoplasma colombiano de zapallo (Cucurbita moschata Dúchesne Exp. Prior)
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Vallejo C. F. A., Montes R. C, and Baena G. D.
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Cucurbita moschata, Germoplasma, Recursos genéticos, Mejoramiento de plantas, caracterización morfológica. ,Agriculture - Abstract
Se colectaron, caracterizaron morfológicamente y evaluaron agronómicamente 133 accesiones de Cucurbita moschata en Colombia (departamentos del Cauca, Valle del Cauca, Risaralda, Quindío, Caldas, Antioquia, Bolívar, Magdalena y Atlántico), las cuales presentaron alta diversidad en tamaño, forma y color de fruto. Los descriptores pubescencia de la hoja, color mancha de la hoja, días a floración masculina, días a floración femenina, espesor de pulpa, tamaño de semilla, forma de margen de semilla, ancho de fruto y peso promedio de fruto permitieron la diferenciación de grupos. Se encontró un índice de diversidad de 62% entre las accesiones colectadas en los departamentos de la región andina con las de la Costa Atlántica. Ninguno de los grupos presentó índices de similaridad del 100%. ABSTRACT This study was carried at Candelaria (Colombia), from August 2001 to July 2003. This study aimed at evaluating, by multivariate analyses techniques, the genetic diversity of 133 accesions, collected from distinct areas of regions of Colombia. The experimental design was of randomized complete blocks with four replications. The data (average) were collected from three plants per plot. Thirteen nine traits were evaluated, 9 vegetatives, 24 reproductives and 1 related to susceptibility to stress. The data were analysed using the herarquical method of WARD and were transformed into a complete disjunctive table, where the modalities of each character is a new variable. The analysis revealed five cluster, with to R2 = 97% and diversity index 62%. The most important characteristics to explain the variability were: days to first female and male flower, fruit width, fruit weight, flesh thickness, leaf pubescence dorsal and ventral surface, colour of leaf spots and seed size. The 5, 7, 47 , 109 and 28 accesion might be recommended for breeding programs. Keywords: Cucurbita moschata, Germplasm, Genetic resources, plant breeding, Morphology characterization.
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- 2004
26. Chemical Composition and Nutrient Loading by Precipitation in the Trachypogon Savannas of the Orinoco Ilanos, Venezuela
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Montes, R. and San Jose, J. J.
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- 1989
27. Fatty-acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort
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Montes, R., Chisaguano, A.M., Castellote, A.I., Morales, E., Sunyer, J., and Lopez-Sabater, M.C.
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Children -- Diseases ,Atopic dermatitis -- Physiological aspects ,Fatty acids -- Physiological aspects -- Health aspects ,Blood plasma -- Physiological aspects -- Health aspects ,Umbilical cord -- Physiological aspects -- Health aspects ,Food/cooking/nutrition ,Health - Abstract
BACKGROUND/OBJECTIVES: Fatty-acid status during in-utero development might influence the risk of atopic diseases in early childhood. The aim of this work was to identify the relationship between maternal plasma and cord blood fatty acid (FA) composition and the risk of atopic eczema in the offspring at 14 months of age. SUBJECTS/METHODS: Two hundred and eleven non-atopic mothers and their children were studied. Mothers were recruited in their first trimester of gestation and children were monitored until 14 months of age. Samples of maternal plasma and cord blood plasma were analyzed to determine the FA profile of total lipids. Presence of atopic eczema in the infants was documented through questionnaires at 6 and 14 months of age. RESULTS: Higher concentrations of total long-chain polyunsaturated FA (LC-PUFA) were found in maternal plasma of non-atopic children in relation to atopic group. Moreover, this maternal plasma LC-PUFA content was negatively correlated with the atopic eczema (odds ratios (OR) = 0.83, P = 0.04) in infants. Regarding cord blood samples, docosahexaenoic acid (DHA C22:6n3) and the sum of total n-3 and of LC-PUFA n-3 showed a negative correlation with the prevalence of the disease (OR = 0.50, 0.49 and 0.49, respectively). CONCLUSIONS: Our results show that the fatty-acid status of the fetus during pregnancy has an important role in the development of atopic eczema in early childhood. The prevalence of this atopic disorder is related to lower cord blood plasma levels of FA belonging to n-3 series, especially DHA. European Journal of Clinical Nutrition (2013) 67, 658-663; doi: 10.1038/ejcn.2013.68; published online 3 April 2013 Keywords: atopic eczema; cord blood; fatty acids; n-3 LC-PUFA; pregnancy, INTRODUCTION Several studies show that maternal intake of fatty acids (FA) during pregnancy is a major determinant of the FA status of infants at birth. Within FA, long-chain polyunsaturated FA [...]
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- 2013
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28. Léxico indígena de flora y fauna en tratados sobre las Indias Occidentales de autores andaluces
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Montes R. María Emilia
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Manuel Galeote ,critica e interpretación ,reseña libro ,Language and Literature ,Philology. Linguistics ,P1-1091 - Abstract
Alrededor de la celebración de los quinientos años del descubrimiento de América se fomentaron y publicaron importantes investigaciones en muchas áreas del conocimiento. En el campo de la lingüística aparecieron nuevas obras dedicadas al estudio de las lenguas amerindias y al español de América. Desde la Cátedra de Historia de la Lengua Española de la Universidad de Granada se impulsan desde entonces una serie de investigaciones que culminaron en tesis doctorales y que abordan fenómenos del español, visto desde las dos orillas.
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- 1999
29. Predictive Factors for Sensory Processing Disorders
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Gandara-Gafo B, Delgado-Lobete L, Santos-del-Riego S, Montes-Montes R, and Vila-Paz A
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Sensory processing ,medicine.medical_treatment ,medicine ,Psychology ,Neuroscience - Abstract
Background: Identifying sensory processing differences in children with sensory reactivity problems (both with and without prenatal and perinatal problems) is essential to providing interventions that enhance development and participation in everyday life. Methods: This study conducted a statistical analysis between the Sensory Profile-2 sensory questionnaire and the study variables: pregnancy, fertility treatment, delivery and prematurity (n=69). Results: This study yielded statistically significant differences in sensory processing at the visual level (p-value=0.003), in proprioception (body position) (p-value
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- 2021
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30. Modelling of genotype by environment interaction to improve the recommendation of sugarcane cultivars for the state of Goiás, Brazil
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MONTES, R. F., BRESEGHELLO, F., DUARTE, J. B., RAFAEL FERREIRA MONTES, UFG, FLAVIO BRESEGHELLO, CNPAF, and JOÃO BATISTA DUARTE, UFG.
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Genotype-environment interaction ,Covariáveis ambientais ,Ensaios multiambientes ,Yields ,Adaptabilidade produtiva ,Cana de Açúcar ,Genótipo ,Environmental factors ,Sugarcane ,Comportamento de Variedade ,Saccharum - Abstract
The objective of this work was to identify environmental factors with significant effects on the genotype by environment interaction (GEI) of sugarcane, and to generate thematic maps yield adaptability of genotypes for the state of Goiás, Brazil, through the integrated use of factorial regression models and the geographic information system (GIS). The study was based on the yield of recoverable sugar (YRS) from cultivar field trials carried out in nine locations. Fourteen environmental factors were used, out of which 11 were divided into 10 crop growth phases, totaling 113 environmental covariates (ECs). The selection of ECs was done by successive simple linear regressions, and the respective genotypic sensitivity coefficients were used to generate adaptability maps. Approximately 57% of the GEI effects were related to the covariates longitude, average temperature at crop germination phase, and maximum temperature at the beginning of the phase of greatest growth. For YRS, the RB034128 and RB034021 clones show specific yield adaptations, and the RB034045 cultivar can share the growing area with the RB867515 check cultivar. Made available in DSpace on 2021-12-06T13:02:25Z (GMT). No. of bitstreams: 1 pab-2021.pdf: 640724 bytes, checksum: 80eff43bcd3ef10bd1a50f9016320d10 (MD5) Previous issue date: 2021
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- 2021
31. Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia
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Chillón, M C, Gómez-Casares, M T, López-Jorge, C E, Rodriguez-Medina, C, Molines, A, Sarasquete, M E, Alcoceba, M, Miguel, J D G-S, Bueno, C, Montes, R, Ramos, F, Rodríguez, J N, Giraldo, P, Ramírez, M, García-Delgado, R, Fuster, J L, González-Díaz, M, and Menendez, P
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- 2012
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32. Insights into the cellular origin and etiology of the infant pro-B acute lymphoblastic leukemia with MLL-AF4 rearrangement
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Bueno, C, Montes, R, Catalina, P, Rodríguez, R, and Menendez, P
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- 2011
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33. Matrix solid-phase dispersion and solid-phase microextraction applied to study the distribution of fenbutatin oxide in grapes and white wine
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Montes, R., Canosa, P., Lamas, J. Pablo, Piñeiro, A., Orriols, I., Cela, R., and Rodríguez, I.
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- 2009
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34. NG2 antigen is expressed in CD34+ HPCs and plasmacytoid dendritic cell precursors: is NG2 expression in leukemia dependent on the target cell where leukemogenesis is triggered?
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Bueno, C, Montes, R, Martín, L, Prat, I, Hernandez, M C, Orfao, A, and Menendez, P
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- 2008
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35. Estimating phthalate exposure at the population level by the analysis of wastewater: case-study within thirteen Spanish cities
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González-Mariño, Iria, Arés, L., Montes, R., Rodil, Rosario, Cela, Rafael, López-García, Ester, Postigo, Cristina, López de Alda, Miren, Pocurull, Eva, Marcé, R., Bijlsma, Lubertus, Hernández, Félix, Picó, Yolanda, Andreu Pérez, V., Rico, A., Valcárcel, Yolanda, Miró, M., Etxebarria, N., Quintana, José, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), and Generalitat Valenciana
- Abstract
Trabajo presentado en la 1ª Jornada sobre Contaminación por Pásticos, celebrada en Barcelona (España) del 27 al 28 de octubre de 2020., Estimating exposure to phthalate plasticizers is crucial to perform appropriate risk assessment and develop control measures. In this study, we analyze wastewater to estimate the exposure to six phthalates within thirteen Spanish cities. Composite daily samples were collected over four consecutive days in Spring 2018 at seventeen wastewater treatment plants serving ca. 6 million people. Concentrations of phthalate metabolites were converted into population-normalized loads and used to estimate (i) metabolite levels in urine, and (ii) values of daily exposure to the parent phthalates. Population-weighted means of the estimated concentrations in urine varied between 0.7 ng/mL and 520 ng/mL. Compared to human biomonitoring data, very high levels were obtained for monomethyl phthalate, metabolite of dimethyl phthalate. This fact, together with literature data pointing to other sources of this metabolite in sewage led to its exclusion for exposure assessment. As for the remaining metabolites, results obtained on a local scale revealed the butylated phthalates as the ones posing the highest concern, particularly for toddlers. On a national scale, including all the sampled sites, di-(2-ethylhexyl) phthalate accounted for the highest percentage of total risk, followed closely by diethyl phthalate and di-iso-butyl phthalate., MCIU/AEI (projects CTM2016-81935-REDT, CTM2017-84763-C3-2-R, CTM2017-84763- C3-3-R, and CEX2018-000794-S), Galician Council of Culture, Education and Universities (ED481D 2017/003 and ED431C2017/36), Generalitat Valenciana (projects Prometeo/2018/155 and Prometeo/2019/040) and Universitat Jaume I (project UJI-B2018-55)
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- 2020
36. Assessment of the Spanish population exposure to phthalate plasticizers as obtained by wastewater-based epidemiology
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González-Mariño, Iria, Rodil, Rosario, Montes, R., Arés, L., Andreu Pérez, V., Bijlsma, Lubertus, Etxebarria, N., Hernández, Félix, López de Alda, Miren, López-García, Ester, Xunta de Galicia, Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), European Commission, and Ministerio de Ciencia, Innovación y Universidades (España)
- Abstract
Resumen del trabajo presentado en el SETAC Europe 30th Annual Meeting, celebrado en modalidad virtual del 3 al 7 de mayo de 2020., Phthalate diesters are high-production-volume chemicals that have been widely used in the manufacturing and processing of plastics for more than 80 years. Recently, they have been included in the priority lists of dangerous substances in most of the industrialized countries. Ingestion is considered the major route of exposure to phthalates, either by consuming contaminated food, accidental ingestion of contaminated dust and soil, or licking of products in which they are contained. Once in the human body, phthalates are hydrolyzed to their corresponding monoesters and further oxidized or conjugated into glucuronide complexes and, finally, excreted. Wastewater-based epidemiology (WBE) is a complementary approach to human biomonitoring to estimate the level of exposure to a substance through the analysis of its metabolic residues in urban wastewater, considering that raw wastewater is a highly diluted urine sample representing an entire community. The objectives of this study were to analyze the metabolites of 6 phthalate diesters in wastewaters from different locations in Spain and to assess the exposure to phthalate diesters in the investigated cities. Raw wastewater samples from 17 wastewater treatment plants, serving a total population of ca. 6 million inhabitants (13% of the Spanish population), were analyzed. The results show that the highest population-weighted exposure loads were obtained for diethyl phthalate, followed by dimethyl phthalate and the isomers di-i-butyl phthalate and di-n-butyl phthalate., The authors acknowledge support by Xunta de Galicia (refs. ED431C2017/36 and IGM postdoctoral contract, Plan Galego I2C-Modalidade B, ED481D 2017/003), the Spanish Research Agency-AEI (ref. CTM2016-81935-REDT/AEI and CTM2017-84763-C3-R-2) and FEDER/ERDF
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- 2020
37. Spatio-temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring
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González-Mariño, I. Baz-Lomba, J.A. Alygizakis, N.A. Andrés-Costa, M.J. Bade, R. Bannwarth, A. Barron, L.P. Been, F. Benaglia, L. Berset, J.-D. Bijlsma, L. Bodík, I. Brenner, A. Brock, A.L. Burgard, D.A. Castrignanò, E. Celma, A. Christophoridis, C.E. Covaci, A. Delémont, O. Devoogt, P. Devault, D.A. Dias, M.J. Emke, E. Esseiva, P. Fatta-Kassinos, D. Fedorova, G. Fytianos, K. Gerber, C. Grabic, R. Gracia-Lor, E. Grüner, S. Gunnar, T. Hapeshi, E. Heath, E. Helm, B. Hernández, F. Kankaanpaa, A. Karolak, S. Kasprzyk-Hordern, B. Krizman-Matasic, I. Lai, F.Y. Lechowicz, W. Lopes, A. de Alda, M.L. López-García, E. Löve, A.S.C. Mastroianni, N. McEneff, G.L. Montes, R. Munro, K. Nefau, T. Oberacher, H. O’brien, J.W. Oertel, R. Olafsdottir, K. Picó, Y. Plósz, B.G. Polesel, F. Postigo, C. Quintana, J.B. Ramin, P. Reid, M.J. Rice, J. Rodil, R. Salgueiro-Gonzàlez, N. Schubert, S. Senta, I. Simões, S.M. Sremacki, M.M. Styszko, K. Terzic, S. Thomaidis, N.S. Thomas, K.V. Tscharke, B.J. Udrisard, R. van Nuijs, A.L.N. Yargeau, V. Zuccato, E. Castiglioni, S. Ort, C.
- Abstract
Background and aims: Wastewater-based epidemiology is an additional indicator of drug use that is gaining reliability to complement the current established panel of indicators. The aims of this study were to: (i) assess spatial and temporal trends of population-normalized mass loads of benzoylecgonine, amphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011–17); (ii) address overall drug use by estimating the average number of combined doses consumed per day in each city; and (iii) compare these with existing prevalence and seizure data. Design: Analysis of daily raw wastewater composite samples collected over 1 week per year from 2011 to 2017. Setting and Participants: Catchment areas of 143 wastewater treatment plants in 120 cities in 37 countries. Measurements: Parent substances (amphetamine, methamphetamine and MDMA) and the metabolites of cocaine (benzoylecgonine) and of Δ9-tetrahydrocannabinol (11-nor-9-carboxy-Δ9-tetrahydrocannabinol) were measured in wastewater using liquid chromatography–tandem mass spectrometry. Daily mass loads (mg/day) were normalized to catchment population (mg/1000 people/day) and converted to the number of combined doses consumed per day. Spatial differences were assessed world-wide, and temporal trends were discerned at European level by comparing 2011–13 drug loads versus 2014–17 loads. Findings: Benzoylecgonine was the stimulant metabolite detected at higher loads in southern and western Europe, and amphetamine, MDMA and methamphetamine in East and North–Central Europe. In other continents, methamphetamine showed the highest levels in the United States and Australia and benzoylecgonine in South America. During the reporting period, benzoylecgonine loads increased in general across Europe, amphetamine and methamphetamine levels fluctuated and MDMA underwent an intermittent upsurge. Conclusions: The analysis of wastewater to quantify drug loads provides near real-time drug use estimates that globally correspond to prevalence and seizure data. © 2019 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction
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- 2020
38. Chemical fingerprint of alcohol and nicotine consumption in Spanish wastewaters
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López-García, Ester, Montes, R., Postigo, Cristina, Rodil, Rosario, González-Mariño, Iria, Andreu Pérez, V., Bijlsma, Lubertus, Hernández, Félix, Marcé, R., Olivares, Maitane, Agencia Estatal de Investigación (España), and Ministerio de Economía y Competitividad (España)
- Abstract
Resumen del trabajo presentado en el SETAC Europe 30th Annual Meeting, celebrado en modalidad virtual del 3 al 7 de mayo de 2020., Wastewater provides a fingerprint of a specific population lifestyle. Tracing the right chemical markers in a wastewater sample allows back-calculating the amount of alcohol and tobacco consumed by the people contributing to that sample. This approach, also known as wastewater-based epidemiology (WBE), provides information on substance abuse in a rapid, anonymous and objective way, complementing the information obtained by traditional methods (surveys, medical and criminal indices, etc). WBE has been used in Spain to estimate the consumption of legal and illicit psychoactive substances. While 4 Spanish cities systematically apply the WBE on an annual basis to report the use of illicit drugs to the European Monitoring Centre for Drugs and Drugs Addiction, the WBE has been only occasionally applied in few cities to estimate alcohol and tobacco use. Based on this, the present work aimed at extending the application of the WBE approach in the Spanish territory (14 cities, 17 WWTPs, 13% of the Spanish population) to obtain a more reliable picture on alcohol and tobacco consumption in the country. This work also aimed at evaluating spatial and weekly consumption trends of these legal drugs and compare WBE-derived data with official consumption figures. For this, 24-h composite wastewater samples were collected at the inlet of 17 wastewater treatment plants (WWTPs) during one week in spring 2018, covering approximately 13% of the Spanish population, and urban areas of different size. The samples collected were analysed for urinary biomarkers of alcohol and nicotine (main psychoactive substance of tobacco). Results showed the presence of the three metabolites in all samples analyzed. Spatial variations in alcohol and nicotine consumption were observed among the investigated cities, and in the case of alcohol, also different consumption patterns were observed during the week. Extrapolation of WBE-derived consumption data at national level showed an annual consumption of alcohol lower than that reported by the World Health Organization (WHO). However, in the case of nicotine, consumption obtained by WBE approach was very similar to tobacco., This work has been supported by the Spanish State Research Agency (Agencia Estatal de Investigación, AEI) through the “Redes de Excelencia” programme, ESAR-Net, ref. CTM2016-81935-REDT
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- 2020
39. ESAR-Net: a collaborative effort to expand the application of wastewater epidemiology in Spain
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Bijlsma, Lubertus, Celma Tirado, A., Hernández, F., González-Mariño, Iria, Montes, R., Rodil, R., Estévez-Danta, Andrea, Postigo, Cristina, López de Alda, Miren, López-García, Ester, Andreu Pérez, V., Picó, Yolanda, Marcé, R., Pocurull, Eva, Rico, A., Valcárcel, Yolanda, Miró, M., Prieto, A., Quintana, José, Agencia Estatal de Investigación (España), and Ministerio de Economía y Competitividad (España)
- Abstract
Resumen del trabajo presentado en el SETAC Europe 30th Annual Meeting, celebrado en modalidad virtual del 3 al 7 de mayo de 2020., Data obtained from wastewater analysis can provide rapid and complementary insights in illict drug consumption at community level. Drug use has been assessed through wastewater analysis at national level in, for example, Australia, Belgium, Finland and South Korea and has also provided annually a one week snapshot of illicit drug volumes consumed in European cities (http://www.emcdda.europa.eu/topics/ pods/waste-water-analysis). However, a wastewater monitoring program did not exist in Spain, but leading experts have formed a network (https://www.esarnet.es/) to promote wastewater-based epidemiology at national level and communicate their findings to authorities and policymakers. Within Europe, Spain is an important country of transit of both cocaine and cannabis, due to its cultural, linguistic and colonial ties to Latin America and its proximity to Morocco. The quantity of seized cocaine and cannabis and prevalence of use, locates Spain at the top of Europe. In this work, a national wastewater campaign has been performed to get more insight on the consumption of illicit drugs and NPS within Spain for the first time. Wastewater results from 14 Spanish cities were compared with previously reported data and other national indicators. The cities, located in 7 of the 17 autonomous communities, cover approximately 6 million inhabitants (12.8 of the Spanish population). Untreated wastewater samples were analyzed for urinary biomarkers of amphetamine, methamphetamine, MDMA, cocaine and cannabis. In addition to these conventional drugs, weekend samples were monitored for several new psychoactive substances (NPS) (i.e. phenethylamines and cathinones). The selected NPS are known as possible replacement of these conventional drugs or among those previously reported. Finally, enantiomeric profiling of amphetamine was performed for one city in order to assure the results were due to consumption and not illegal dumping of production residues. This demonstrates another application of wastewater-based epidemiology, which allows to identify the originof drugs in wastewater., This work has been supported by the Spanish State Research Agency (Agencia Estatal de Investigación, AEI) through the “Redes de Excelencia” programme, ESAR-Net, ref. CTM2016-81935-REDT
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- 2020
40. El análisis de aguas residuales con fines epidemiológicos: presente y futuro en España Wastewater-based epidemiology: present and future in Spain
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Pocurull, E., Marcé, R.M., González-Mariño, I., Rodil, R., Montes, R., Estévez-Danta, A., Andreu, V., Bijlsma, L., Celma, A., Hernández, F., López de Alda, M., López-García, E., Picó, Y., Postigo, C., Rico, A., and Valcárcel, Y.
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Q Science (General) - Published
- 2020
41. Sonidos, fonemas y morfemas
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Montes R. María Helena
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Juan Hasler ,critica e interpretación ,reseña libro ,Language and Literature ,Philology. Linguistics ,P1-1091 - Abstract
Hasler, Juan. 2003. Sonidos, fonemas y morfemas. Cali: universidad del valle. La Universidad del Valle y el autor han decidido reeditar y ampliar un volumen, aparecido inicialmente en 1994 dentro de una de las colecciones de la editorial universitaria con el título de Fonemas y Morfemas. Una praxis analítica.
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- 2003
42. Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity
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LÓPEZ‐SAGASETA, J., MONTES, R., PUY, C., DÍEZ, N., FUKUDOME, K., and HERMIDA, J.
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- 2007
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43. Identity tests: determination of cell line cross-contamination
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Cabrera, C. M., Cobo, F., Nieto, A., Cortés, J. L., Montes, R. M., Catalina, P., and Concha, A.
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- 2006
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44. Autoantibodies against endothelial protein C receptor and the risk of a first deep vein thrombosis
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VAN HYLCKAMA VLIEG, A., MONTES, R., ROSENDAAL, F.R., and HERMIDA, J.
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- 2007
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45. Proteolysis of the endothelial cell protein C receptor by neutrophil proteinase 3
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VILLEGAS‐MENDEZ, A., MONTES, R., AMBROSE, L.R., WARRENS, A.N., LAFFAN, M., and LANE, D.A.
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- 2007
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46. Proteomic analysis and biochemical alterations in marine mussel gills after exposure to the organophosphate flame retardant TDCPP
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Sánchez-Marín, Paula, Vidal-Liñán, Leticia, Fernández-González, L.E., Montes, R., Rodil, R., Quintana, J.B., Carrera, M., Mateos, J., Diz, A.P., Beiras, R., Sánchez-Marín, Paula, Vidal-Liñán, Leticia, Fernández-González, L.E., Montes, R., Rodil, R., Quintana, J.B., Carrera, M., Mateos, J., Diz, A.P., and Beiras, R.
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- 2020
47. Assessment of the Spanish population exposure to phthalate plasticizers as obtained by wastewater-based epidemiology
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Xunta de Galicia, Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), González-Mariño, Iria, Rodil, Rosario, Montes, R., Arés, L., Andreu Pérez, V., Bijlsma, Lubertus, Etxebarria, N., Hernández, Félix, López de Alda, Miren, López-García, Ester, Xunta de Galicia, Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), González-Mariño, Iria, Rodil, Rosario, Montes, R., Arés, L., Andreu Pérez, V., Bijlsma, Lubertus, Etxebarria, N., Hernández, Félix, López de Alda, Miren, and López-García, Ester
- Abstract
Phthalate diesters are high-production-volume chemicals that have been widely used in the manufacturing and processing of plastics for more than 80 years. Recently, they have been included in the priority lists of dangerous substances in most of the industrialized countries. Ingestion is considered the major route of exposure to phthalates, either by consuming contaminated food, accidental ingestion of contaminated dust and soil, or licking of products in which they are contained. Once in the human body, phthalates are hydrolyzed to their corresponding monoesters and further oxidized or conjugated into glucuronide complexes and, finally, excreted. Wastewater-based epidemiology (WBE) is a complementary approach to human biomonitoring to estimate the level of exposure to a substance through the analysis of its metabolic residues in urban wastewater, considering that raw wastewater is a highly diluted urine sample representing an entire community. The objectives of this study were to analyze the metabolites of 6 phthalate diesters in wastewaters from different locations in Spain and to assess the exposure to phthalate diesters in the investigated cities. Raw wastewater samples from 17 wastewater treatment plants, serving a total population of ca. 6 million inhabitants (13% of the Spanish population), were analyzed. The results show that the highest population-weighted exposure loads were obtained for diethyl phthalate, followed by dimethyl phthalate and the isomers di-i-butyl phthalate and di-n-butyl phthalate.
- Published
- 2020
48. ESAR-Net: a collaborative effort to expand the application of wastewater epidemiology in Spain
- Author
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Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Bijlsma, Lubertus, Celma Tirado, A., Hernández, F., González-Mariño, Iria, Montes, R., Rodil, R., Estévez-Danta, Andrea, Postigo, Cristina, López de Alda, Miren, López-García, Ester, Andreu Pérez, V., Picó, Yolanda, Marcé, Rosa María, Pocurull, Eva, Rico, A., Valcárcel, Yolanda, Miró, Manuel, Prieto, A., Quintana, José, Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Bijlsma, Lubertus, Celma Tirado, A., Hernández, F., González-Mariño, Iria, Montes, R., Rodil, R., Estévez-Danta, Andrea, Postigo, Cristina, López de Alda, Miren, López-García, Ester, Andreu Pérez, V., Picó, Yolanda, Marcé, Rosa María, Pocurull, Eva, Rico, A., Valcárcel, Yolanda, Miró, Manuel, Prieto, A., and Quintana, José
- Abstract
Data obtained from wastewater analysis can provide rapid and complementary insights in illict drug consumption at community level. Drug use has been assessed through wastewater analysis at national level in, for example, Australia, Belgium, Finland and South Korea and has also provided annually a one week snapshot of illicit drug volumes consumed in European cities (http://www.emcdda.europa.eu/topics/ pods/waste-water-analysis). However, a wastewater monitoring program did not exist in Spain, but leading experts have formed a network (https://www.esarnet.es/) to promote wastewater-based epidemiology at national level and communicate their findings to authorities and policymakers. Within Europe, Spain is an important country of transit of both cocaine and cannabis, due to its cultural, linguistic and colonial ties to Latin America and its proximity to Morocco. The quantity of seized cocaine and cannabis and prevalence of use, locates Spain at the top of Europe. In this work, a national wastewater campaign has been performed to get more insight on the consumption of illicit drugs and NPS within Spain for the first time. Wastewater results from 14 Spanish cities were compared with previously reported data and other national indicators. The cities, located in 7 of the 17 autonomous communities, cover approximately 6 million inhabitants (12.8 of the Spanish population). Untreated wastewater samples were analyzed for urinary biomarkers of amphetamine, methamphetamine, MDMA, cocaine and cannabis. In addition to these conventional drugs, weekend samples were monitored for several new psychoactive substances (NPS) (i.e. phenethylamines and cathinones). The selected NPS are known as possible replacement of these conventional drugs or among those previously reported. Finally, enantiomeric profiling of amphetamine was performed for one city in order to assure the results were due to consumption and not illegal dumping of production residues. This demonstrates another applicatio
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- 2020
49. Chemical fingerprint of alcohol and nicotine consumption in Spanish wastewaters
- Author
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Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), López-García, Ester, Montes, R., Postigo, Cristina, Rodil, Rosario, González-Mariño, Iria, Andreu Pérez, V., Bijlsma, Lubertus, Hernández, Félix, Marcé, Rosa María, Olivares, Maitane, Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), López-García, Ester, Montes, R., Postigo, Cristina, Rodil, Rosario, González-Mariño, Iria, Andreu Pérez, V., Bijlsma, Lubertus, Hernández, Félix, Marcé, Rosa María, and Olivares, Maitane
- Abstract
Wastewater provides a fingerprint of a specific population lifestyle. Tracing the right chemical markers in a wastewater sample allows back-calculating the amount of alcohol and tobacco consumed by the people contributing to that sample. This approach, also known as wastewater-based epidemiology (WBE), provides information on substance abuse in a rapid, anonymous and objective way, complementing the information obtained by traditional methods (surveys, medical and criminal indices, etc). WBE has been used in Spain to estimate the consumption of legal and illicit psychoactive substances. While 4 Spanish cities systematically apply the WBE on an annual basis to report the use of illicit drugs to the European Monitoring Centre for Drugs and Drugs Addiction, the WBE has been only occasionally applied in few cities to estimate alcohol and tobacco use. Based on this, the present work aimed at extending the application of the WBE approach in the Spanish territory (14 cities, 17 WWTPs, 13% of the Spanish population) to obtain a more reliable picture on alcohol and tobacco consumption in the country. This work also aimed at evaluating spatial and weekly consumption trends of these legal drugs and compare WBE-derived data with official consumption figures. For this, 24-h composite wastewater samples were collected at the inlet of 17 wastewater treatment plants (WWTPs) during one week in spring 2018, covering approximately 13% of the Spanish population, and urban areas of different size. The samples collected were analysed for urinary biomarkers of alcohol and nicotine (main psychoactive substance of tobacco). Results showed the presence of the three metabolites in all samples analyzed. Spatial variations in alcohol and nicotine consumption were observed among the investigated cities, and in the case of alcohol, also different consumption patterns were observed during the week. Extrapolation of WBE-derived consumption data at national level showed an annual consumption of alco
- Published
- 2020
50. Estimating phthalate exposure at the population level by the analysis of wastewater: case-study within thirteen Spanish cities
- Author
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Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Generalitat Valenciana, González-Mariño, Iria, Arés, L., Montes, R., Rodil, Rosario, Cela, Rafael, López-García, Ester, Postigo, Cristina, López de Alda, Miren, Pocurull, Eva, Marcé, Rosa María, Bijlsma, Lubertus, Hernández, Félix, Picó, Yolanda, Andreu Pérez, V., Rico, A., Valcárcel, Yolanda, Miró, Manuel, Etxebarria, N., Quintana, José, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Generalitat Valenciana, González-Mariño, Iria, Arés, L., Montes, R., Rodil, Rosario, Cela, Rafael, López-García, Ester, Postigo, Cristina, López de Alda, Miren, Pocurull, Eva, Marcé, Rosa María, Bijlsma, Lubertus, Hernández, Félix, Picó, Yolanda, Andreu Pérez, V., Rico, A., Valcárcel, Yolanda, Miró, Manuel, Etxebarria, N., and Quintana, José
- Abstract
Estimating exposure to phthalate plasticizers is crucial to perform appropriate risk assessment and develop control measures. In this study, we analyze wastewater to estimate the exposure to six phthalates within thirteen Spanish cities. Composite daily samples were collected over four consecutive days in Spring 2018 at seventeen wastewater treatment plants serving ca. 6 million people. Concentrations of phthalate metabolites were converted into population-normalized loads and used to estimate (i) metabolite levels in urine, and (ii) values of daily exposure to the parent phthalates. Population-weighted means of the estimated concentrations in urine varied between 0.7 ng/mL and 520 ng/mL. Compared to human biomonitoring data, very high levels were obtained for monomethyl phthalate, metabolite of dimethyl phthalate. This fact, together with literature data pointing to other sources of this metabolite in sewage led to its exclusion for exposure assessment. As for the remaining metabolites, results obtained on a local scale revealed the butylated phthalates as the ones posing the highest concern, particularly for toddlers. On a national scale, including all the sampled sites, di-(2-ethylhexyl) phthalate accounted for the highest percentage of total risk, followed closely by diethyl phthalate and di-iso-butyl phthalate.
- Published
- 2020
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