Search

Your search keyword '"Momoi, Nobuo"' showing total 43 results
Start Over Author "Momoi, Nobuo" Search Limiters Full Text
43 results on '"Momoi, Nobuo"'

1. Risk factors for discontinuation of exclusive breast feeding within 1month: a retrospective cohort study in Japan

Author

Yasuda, Shun, Fukuda, Toma, Toba, Naoya, Kamo, Norihito, Imaizumi, Karin, Yokochi, Midori, Okawara, Tomoko, Takano, Seiko, Yoshida, Hideko, Kobayashi, Nobuko, Kudo, Shingo, Miyazaki, Kyohei, Hosoya, Mamiko, Sato, Kenichi, Takano, Kei, Kanno, Aya, Murata, Tsuyoshi, Kyozuka, Hyo, Yamaguchi, Akiko, Ito, Fumihiro, Oda, Shinichiro, Momoi, Nobuo, Hosoya, Mitsuaki, and Fujimori, Keiya

Published
2022
Full Text
View/download PDF

2. Calmodulinopathy in Japanese Children ― Their Cardiac Phenotypes Are Severe and Show Early Onset in Fetal Life and Infancy ―

Author

Fukuyama, Megumi, primary, Horie, Minoru, additional, Kato, Koichi, additional, Aoki, Hisaaki, additional, Fujita, Shuhei, additional, Yoshida, Yoko, additional, Sakazaki, Hisanori, additional, Toda, Takako, additional, Ueno, Michihiko, additional, Izumi, Gaku, additional, Momoi, Nobuo, additional, Muneuchi, Jun, additional, Makiyama, Takeru, additional, Nakagawa, Yoshihisa, additional, and Ohno, Seiko, additional

Published
2023
Full Text
View/download PDF

8. Increased Burden of Ion Channel Gene Variants Is Related to Distinct Phenotypes in Pediatric Patients With Left Ventricular Noncompaction

Author

Hirono, Keiichi, primary, Hata, Yukiko, additional, Miyao, Nariaki, additional, Okabe, Mako, additional, Takarada, Shinya, additional, Nakaoka, Hideyuki, additional, Ibuki, Keijiro, additional, Ozawa, Sayaka, additional, Origasa, Hideki, additional, Nishida, Naoki, additional, Ichida, Fukiko, additional, Takeda, Atsuhito, additional, Shimabukuro, Atsuya, additional, Akita, Chisato, additional, Fukumi, Daichi, additional, Nishihara, Eiki, additional, Tsuda, Etsuko, additional, Sakaguchi, Heima, additional, Ishida, Hidekazu, additional, Tomita, Hideshi, additional, Kise, Hiroaki, additional, Nagamine, Hiroki, additional, Uchiyama, Hiroki, additional, Katayama, Hiromi, additional, Ooki, Hiroo, additional, Nishikawa, Hiroshi, additional, Ono, Hiroshi, additional, Horigome, Hisanori Sakazaki, Hitoshi, additional, Muneuchi, Jun, additional, Yoshimoto, Jun, additional, Soumura, Junpei, additional, Kamada, Masahiro, additional, Yasuda, Kazushi, additional, Ikeda, Kazuyuki, additional, Yasuda, Keiji, additional, Kurosaki, Kenichi, additional, Mine, Kenji, additional, Ueno, Kentaro, additional, Takigiku, Kiyohiro, additional, Ogawa, Kiyoshi, additional, Inaguma, Kotaro, additional, Oyama, Kotaro, additional, Urayama, Kotaro, additional, Takahashi, Kunihiko, additional, Ohta, Kunio, additional, Nakazawa, Makoto, additional, Nakayashiro, Mami, additional, Ayusawa, Mamoro, additional, Toyono, Manatomo, additional, Nii, Masaki, additional, Miura, Masaru, additional, Fujino, Mitsuhiro, additional, Kuwabara, Naoshi, additional, Momoi, Nobuo, additional, Tsujii, Nobuyuki, additional, Motoki, Noriko, additional, Matsuo, Osamu, additional, Baba, Reizo, additional, Inuzuka, Ryo, additional, Kido, Sachiko, additional, Iwashima, Satoru, additional, Yasukochi, Satoshi, additional, Okada, Seigo, additional, Sato, Seiichi, additional, Mitsuru, Seki, additional, Kogaki, Shigetoyo, additional, Hoshino, Shinsuke, additional, Tsukano, Shinya, additional, Fujita, Shuhei, additional, Kimura, Sumito, additional, Urata, Susumu, additional, Kato, Taichi, additional, Toda, Takako, additional, Uchiyama, Takamichi, additional, Shindo, Takahiro, additional, Higaki, Takashi, additional, Kobayashi, Tomio, additional, Ozaki, Tomoyasu, additional, Tanaka, Yasuhiko, additional, Katsube, Yasuhiro, additional, Hamabuchi, Yasunobu, additional, Kajiyama, Yo, additional, Yoshida, Yoko, additional, Murakami, Yosuke, additional, Abe, Yuriko, additional, Hiraumi, Yoshimi, additional, Fukuda, Yutaka, additional, and Odanaka, Yutaka, additional

Published
2020
Full Text
View/download PDF

9. Extracellular vesicle miRNA-21 is a potential biomarker for predicting chronic lung disease in premature infants

Author

Go, Hayato, primary, Maeda, Hajime, additional, Miyazaki, Kyohei, additional, Maeda, Ryo, additional, Kume, Yohei, additional, Namba, Fumihiko, additional, Momoi, Nobuo, additional, Hashimoto, Koichi, additional, Otsuru, Satoru, additional, Kawasaki, Yukihiko, additional, Hosoya, Mitsuaki, additional, and Dennery, Phyllis A, additional

Published
2020
Full Text
View/download PDF

12. Percutaneous evacuation of diffuse pulmonary interstitial emphysema by lung puncture in a baby with extremely low birth weight: a case report

Author

Watanabe Masahiro, Momoi Nobuo, Sato Maki, Go Hayato, Imamura Takashi, Kaneko Masatoshi, and Hosoya Mitsuaki

Subjects
Lung puncture, Pulmonary interstitial emphysema, Baby with extremely low birth weight, Medicine
Abstract

Abstract Introduction Pulmonary interstitial emphysema is a serious complication of mechanical ventilation and can become life-threatening if progression occurs. Therapeutic lung puncture is a treatment option for severe pulmonary interstitial emphysema but has a limited use in babies with extremely low birth weight. We present a case of pulmonary interstitial emphysema in a Japanese baby (1-day-old) boy with extremely low birth weight. The emphysema was successfully decompressed by therapeutic lung puncture performed with a trocar catheter. Case presentation The baby was born with a weight of 420g, which, to the best of our knowledge, is the lowest reported birth weight among babies with pulmonary interstitial emphysema. A chest X-ray on postnatal day 2 revealed pulmonary interstitial emphysema, which gradually progressed to diffuse pseudocystic changes. His condition became life-threatening despite the use of high-frequency oscillatory ventilation and lateral decubitus positioning. We evacuated the pulmonary interstitial emphysema by lung puncture with a trocar catheter to avoid respiratory and cardiovascular collapse. This resulted in adequate evacuation of the emphysema and a dramatic improvement in his clinical condition. Conclusions Therapeutic lung puncture performed with a trocar catheter is beneficial in babies with extremely low birth weight and diffuse pulmonary interstitial emphysema. This treatment option may be broadly applicable, especially in an emergency situation.

Published
2012
Full Text
View/download PDF

14. Clinical and Echocardiographic Impact of Tafazzin Variants on Dilated Cardiomyopathy Phenotype in Left Ventricular Non-Compaction Patients in Early Infancy

Author

Hirono, Keiichi, primary, Hata, Yukiko, additional, Nakazawa, Makoto, additional, Momoi, Nobuo, additional, Tsuji, Tohru, additional, Matsuoka, Taro, additional, Ayusawa, Mamoru, additional, Abe, Yuriko, additional, Hayashi, Tamaki, additional, Tsujii, Nobuyuki, additional, Abe, Tadaaki, additional, Sakaguchi, Heima, additional, Wang, Ce, additional, Takasaki, Asami, additional, Takarada, Shinya, additional, Okabe, Mako, additional, Miyao, Nariaki, additional, Nakaoka, Hideyuki, additional, Ibuki, Keijiro, additional, Saito, Kazuyoshi, additional, Ozawa, Sayaka, additional, Nishida, Naoki, additional, Bowles, Neil E., additional, and Ichida, Fukiko, additional

Published
2018
Full Text
View/download PDF

17. Volumetric Analysis of Gallbladder in Extremely Premature Infants

Author

Imamura, Takashi, primary, Sato, Maki, additional, Go, Hayato, additional, Ogasawara, Kei, additional, Kanai, Yuji, additional, Chishiki, Mina, additional, Maeda, Hajime, additional, Haneda, Kentarou, additional, Kashiwabara, Nozomi, additional, Goto, Aya, additional, Momoi, Nobuo, additional, and Hosoya, Mitsuaki, additional

Published
2017
Full Text
View/download PDF

23. Maternal hypoxia and caffeine exposure depress fetal cardiovascular function during primary organogenesis

Author

Momoi, Nobuo, Tinney, Joseph P., Keller, Bradley B., and Tobita, Kimimasa

Subjects
Male, Organogenesis, Hemodynamics, Stroke Volume, Heart Rate, Fetal, Article, Pregnancy Complications, Mice, Fetal Heart, Purinergic P1 Receptor Antagonists, Pregnancy, Caffeine, Animals, Female, Hypoxia
Abstract

Hypoxia is known to influence cardiovascular (CV) function, in part, through adenosine receptor activation. We have shown in a mouse model that during primary cardiac morphogenesis, acute maternal hypoxia negatively affects fetal heart rate, and recurrent maternal caffeine exposure reduces fetal cardiac output (CO) and downregulates fetal adenosine A(2A) receptor gene expression. In the present study, we investigated whether maternal caffeine dosing exacerbates the fetal CV response to acute maternal hypoxia during the primary morphogenesis period.Gestational-day-11.5 pregnant mice were exposed to hypoxia (45 s duration followed by 10 min of recovery and repeated 3 times) while simultaneously monitoring maternal and fetal CO using high-resolution echocardiography. Following maternal hypoxia exposure, maternal CO transiently decreased and then returned to pre-hypoxia baseline values. In contrast to a uniform maternal cardiac response to each exposure to hypoxia, the fetal CO recovery time to the baseline decreased, and CO rebounded above baseline following the second and third episodes of maternal hypoxia. Maternal caffeine treatment inhibited the fetal CO recovery to maternal hypoxia by lengthening the time to CO recovery and eliminating the CO rebound post-recovery. Selective treatment with an adenosine A(2A) receptor antagonist, but not an adenosine A(1) receptor antagonist, reproduced the altered fetal CO response to maternal hypoxia created by caffeine exposure. Results suggest an additive negative effect of maternal caffeine on the fetal CV response to acute maternal hypoxia, potentially mediated via adenosine A(2A) receptor inhibition during primary cardiovascular morphogenesis.

Published
2012

24. Clinical Characteristics of Brain Abscess in Cyanotic Congenital Heart Disease in Japan

Author

Maeda, Jun, primary, Furutani, Yoshiyuki, additional, Inai, Kei, additional, Oana, Shinji, additional, Kajino, Hiroki, additional, Kamisago, Mitsuhiro, additional, Matsuura, Hiroyuki, additional, Matsuoka, Rumiko, additional, Mori, Katsuhiko, additional, Suda, Kenji, additional, Iijima, Masatoshi, additional, Ikehara, Satoshi, additional, Ohki, Hirotaka, additional, Kanamaru, Hiroshi, additional, Tauchi, Nobuki, additional, Nakajima, Hiromichi, additional, Nishihara, Eiki, additional, Hamaoka, Tateki, additional, Hayabuchi, Yasunobu, additional, Horigome, Hitoshi, additional, Momoi, Nobuo, additional, Yasuda, Kenji, additional, Yokozawa, Masato, additional, Arakaki, Yoshio, additional, Ichida, Fukiko, additional, Ono, Yasuo, additional, Koyama, Koutaro, additional, Kuroe, Kenji, additional, Kobayashi, Toshiki, additional, Joo, Kunitaka, additional, Shiraishi, Isao, additional, Nakagawa, Masao, additional, Nomura, Yuuichi, additional, Fusazaki, Naoki, additional, Murakami, Tomoaki, additional, Yasukouchi, Satoshi, additional, Yasuda, Toshitetsu, additional, Nakanishi, Toshio, additional, and Yamagishi, Hiroyuki, additional

Published
2013
Full Text
View/download PDF

31. Percutaneous evacuation of diffuse pulmonary interstitial emphysema by lung puncture in a baby with extremely low birth weight: a case report.

Author

Masahiro Watanabe, Nobuo Momoi, Maki Sato, Hayato Go, Takashi Imamura, Masatoshi Kaneko, Mitsuaki Hosoya, Watanabe, Masahiro, Momoi, Nobuo, Sato, Maki, Go, Hayato, Imamura, Takashi, Kaneko, Masatoshi, and Hosoya, Mitsuaki

Subjects
INTERSTITIAL cells, PULMONARY emphysema, BIRTH weight, DISEASE progression
Abstract

Unlabelled: Introduction: Pulmonary interstitial emphysema is a serious complication of mechanical ventilation and can become life-threatening if progression occurs. Therapeutic lung puncture is a treatment option for severe pulmonary interstitial emphysema but has a limited use in babies with extremely low birth weight. We present a case of pulmonary interstitial emphysema in a Japanese baby (1-day-old) boy with extremely low birth weight. The emphysema was successfully decompressed by therapeutic lung puncture performed with a trocar catheter.Case Presentation: The baby was born with a weight of 420g, which, to the best of our knowledge, is the lowest reported birth weight among babies with pulmonary interstitial emphysema. A chest X-ray on postnatal day 2 revealed pulmonary interstitial emphysema, which gradually progressed to diffuse pseudocystic changes. His condition became life-threatening despite the use of high-frequency oscillatory ventilation and lateral decubitus positioning. We evacuated the pulmonary interstitial emphysema by lung puncture with a trocar catheter to avoid respiratory and cardiovascular collapse. This resulted in adequate evacuation of the emphysema and a dramatic improvement in his clinical condition.Conclusions: Therapeutic lung puncture performed with a trocar catheter is beneficial in babies with extremely low birth weight and diffuse pulmonary interstitial emphysema. This treatment option may be broadly applicable, especially in an emergency situation. [ABSTRACT FROM AUTHOR]

Published
2012
Full Text
View/download PDF

34. Inhibitory Effect of Thiopental on Ultra-rapid Delayed Rectifier K+Current in H9c2 Cells

Author

Suzuki, Hideki, Momoi, Nobuo, Ono, Tomoyuki, Maeda, Sachiko, Shikama, Yayoi, Matsuoka, Isao, Suzuki, Hitoshi, and Kimura, Junko

Abstract

Using the whole-cell voltage clamp technique, we investigated the effects of thiopental on membrane currents in H9c2 cells, a cell line derived from embryonic rat heart. Thiopental blocked a rapidly activating, very slowly-inactivating ultra-rapid type IKur-like outward K+current in a concentration-dependent manner. The half-maximal concentration (IC50) of thiopental was 97 µM with a Hill coefficient of 1.2. The thiopental-sensitive current was also blocked by high concentrations of nifedipine (IC50= 9.1 µM) and 100 µM chromanol 293B, a blocker of slowly activating delayed rectifier K+current (IKs), but was insensitive to E-4031, an inhibitor of rapidly activating delayed rectifier K+current (IKr). TEA (tetraethylammonium) at 5 mM and 4-AP (4-aminopiridine) at 1 mM reduced the K+current to 30.8 ± 12.2% and 20.5 ± 6.5% of the control, respectively. Using RT-PCR, we detected mRNAs of Kv2.1, Kv3.4, Kv4.1, and Kv4.3 in H9c2 cells. Among those, Kv2.1 and Kv3.4 have IKur-type kinetics and are therefore candidates for thiopental-sensitive K+channels in H9c2 cells. This is the first report showing that thiopental inhibits IKur. This effect of thiopental may be involved in its reported prolongation of cardiac action potentials.

Published
2005
Full Text
View/download PDF

37. 923. Muscle Stem Cells Genetically Modified to Express a VEGF Antagonist Display an Impaired Ability for Cardiac Repair

Author

Payne, Thomas R., Oshima, Hideki, Okada, Masaho, Momoi, Nobuo, Tobita, Kimimasa, Keller, Bradley B., Peng, Hairong, and Huard, Johnny

Subjects
*STEM cells
Abstract

An abstract of the article "Muscle Stem Cells Genetically Modified to Express a VEGF Antagonist Display an Impaired Ability for Cardiac Repair," by Thomas R. Payne and colleagues is presented.

Published
2005
Full Text
View/download PDF

38. Determination of Genotype and Phenotypes in Pediatric Patients With Biventricular Noncompaction.

Author

Hirono K, Hata Y, Imamura T, Tsuboi K, Takarada S, Okabe M, Nakaoka H, Ibuki K, Ozawa S, Ichimata S, Nishida N, Iwasaki H, Urata S, Okada S, Hiratsuji T, Sakaguchi H, Takigiku K, Nakazawa M, Nishihara E, Harada M, Matsuo O, Yasuda K, Yoshida Y, Namiki H, Yasuda K, Ifuku T, Urayama K, Oka H, Ogino K, Kato A, Kan N, Seki S, Seki M, Odanaka Y, Iwashima S, Yoshida S, Miyata T, Miyamoto T, Watanabe K, Kuwabara N, Inuzuka R, Takahashi Y, Sakazaki H, Muneuchi J, Kogaki S, Numano F, Kido S, Nii M, Hoshino S, Ishida H, Maeda J, Hayabuchi Y, Otsubo Y, Ikeda K, Tsukano S, Watanabe M, Momoi N, Fujii T, Fujioka T, Fujino M, Uchiyama H, Baba S, Horigome H, Honda T, Suzuki K, and Ichida F

Subjects
Humans, Male, Female, Infant, Child, Preschool, Child, Infant, Newborn, Heart Defects, Congenital genetics, Heart Defects, Congenital mortality, Heart Defects, Congenital diagnosis, Japan epidemiology, Genotype, Genetic Predisposition to Disease, Isolated Noncompaction of the Ventricular Myocardium genetics, Isolated Noncompaction of the Ventricular Myocardium physiopathology, Isolated Noncompaction of the Ventricular Myocardium diagnosis, Isolated Noncompaction of the Ventricular Myocardium mortality, Cardiomyopathies genetics, Cardiomyopathies physiopathology, Retrospective Studies, Phenotype
Abstract

Background: Left ventricular noncompaction (LVNC) is a hereditary type of cardiomyopathy characterized by prominent trabeculations. Detailed characteristics of biventricular noncompaction (BiVNC) remain unknown. This study aimed to elucidate the clinical characteristics and genetic landscape of BiVNC., Methods and Results: We recruited children with left ventricular noncompaction from Japanese multi-institutional centers from 2013 to 2021. Left ventricular noncompaction was classified as BiVNC, congenital heart disease, arrhythmia, dilated cardiomyopathy, or normal function. In these patients, cardiomyopathy-associated genes were screened. A total of 234 patients (127 male; mean age, 4 months [range, 0-6.6 years]) were enrolled in this study, of whom 25 had BiVNC; 55, normal function; 84, dilated cardiomyopathy; 38, congenital heart disease; and 32, arrhythmia. BiVNC was diagnosed during the perinatal period in 10 patients, in whom the prevalence was higher than that in other patients. A total of 14 patients in the group with BiVNC had congenital heart disease, but not necessarily right heart lesions. Left ventricular dyskinesis was frequently observed in the lateral wall (24%) and apex (28%). Eleven pathogenic variants were found in 11 patients with BiVNC (44.0%). The group with BiVNC had a higher ratio of mitochondrial and developmental gene variants than the other groups. Among all groups, the group with BiVNC had the worst survival rate ( P =0.0009)., Conclusions: Pediatric patients with BiVNC had a high rate of ventricular dyskinesis and poor outcome. A comprehensive and careful screening for disease-causing genes and phenotype may help identify specific patients with left ventricular noncompaction and mortality-related cardiac phenotypes.

Published
2024
Full Text
View/download PDF

39. Extracellular vesicle miRNA-21 is a potential biomarker for predicting chronic lung disease in premature infants.

Author

Go H, Maeda H, Miyazaki K, Maeda R, Kume Y, Namba F, Momoi N, Hashimoto K, Otsuru S, Kawasaki Y, Hosoya M, and Dennery PA

Subjects
Animals, Animals, Newborn, Antagomirs genetics, Antagomirs metabolism, Biomarkers metabolism, Chronic Disease, Disease Models, Animal, Extracellular Vesicles chemistry, Extracellular Vesicles metabolism, Female, Gene Expression Profiling, Gene Expression Regulation, Humans, Hyperoxia blood, Hyperoxia physiopathology, Infant, Newborn, Infant, Premature, Lung Diseases blood, Lung Diseases physiopathology, Male, Mice, Mice, Inbred C57BL, MicroRNAs agonists, MicroRNAs antagonists & inhibitors, MicroRNAs blood, MicroRNAs classification, Oligonucleotide Array Sequence Analysis, Oligoribonucleotides genetics, Oligoribonucleotides metabolism, Prognosis, Hyperoxia diagnosis, Hyperoxia genetics, Lung Diseases diagnosis, Lung Diseases genetics, MicroRNAs genetics
Abstract

Premature infants are often exposed to positive pressure ventilation and supplemental oxygen, which leads to the development of chronic lung disease (CLD). There are currently no standard serum biomarkers used for prediction or early detection of patients who go on to develop CLD. MicroRNAs (miRNAs) are a novel class of naturally occurring, short, noncoding substances that regulate gene expression at the posttranscriptional level and cause translational inhibition and/or mRNA degradation and present in body fluids packaged in extracellular vesicles (EVs), rendering them remarkably stable. Our aim was to evaluate miRNAs identified in serum EVs of premature infants as potential biomarkers for CLD. Serum EVs were extracted from premature infants at birth and on the 28th day of life (DOL). Using a human miRNA array, we identified 62 miRNAs that were universally expressed in CLD patients and non-CLD patients. Of the 62 miRNAs, 59 miRNAs and 44 miRNAs were differentially expressed on DOL0 and DOL28 in CLD and non-CLD patients, respectively. Of these miRNAs, serum EV miR-21 was upregulated in CLD patients on DOL28 compared with levels at birth and downregulated in non-CLD patients on DOL28 compared with levels at birth. In neonatal mice exposed to hyperoxia for 7days, as a model of CLD, five miRNAs (miR-34a, miR-21, miR-712, miR-682, and miR-221) were upregulated, and 7 miRNAs (miR-542-5p, miR-449a, miR-322, miR-190b, miR-153, miR-335-3p, miR-377) were downregulated. MiR-21 was detected as a common miRNA that changed in CLD patients and in the hyperoxia exposed mice. We conclude that EV miR-21 may be a biomarker of CLD.

Published
2020
Full Text
View/download PDF

40. Myelomeningocele with Unilateral Right Renal Agenesis: A Case Report.

Author

Maeda H, Go H, Sakuma J, Imamura T, Sato M, Momoi N, and Hosoya M

Abstract

Congenital anomalies of the spine may occur with malformations of the central nervous, cardiovascular, gastrointestinal, respiratory, and genitourinary systems. This is a case of myelomeningocele with unilateral right renal agenesis in a newborn. The patient suffered complications of cerebrospinal fluid leak and meningitis, but was successfully treated and discharged on day 86. In this case, unilateral right renal agenesis represented a significant surgical risk because failure of the remaining kidney could result in renal failure. Because congenital anomalies of the spine may be associated with malformations of the genitourinary system, and additional surgeries were necessary in our case following birth, it is very important that the presence of genitourinary malformations be evaluated.

Published
2018
Full Text
View/download PDF

41. Early Postnatal Seizures in a Neonate with Wolf-Hirschhorn Syndrome.

Author

Go H, Haneda K, Maeda H, Ogasawara K, Imamura T, Momoi N, and Hosoya M

Abstract

Background  Wolf-Hirschhorn syndrome (WHS), which is characterized by a typical facial appearance, growth retardation, mental retardation, seizures, and congenital cardiac defects, has an estimated incidence of 1 per 50,000 births. Case  We report a case of a low birth weight neonate with WHS and seizures, as well as persistent pulmonary hypertension in the early neonatal period. Apgar scores were 6 (1 minute) and 8 (5 minutes) with evident retraction. After admission to the neonatal intensive care unit, the patient had tonic-clonic seizures with epilepticus 30 minute after birth. Although the seizures were uncontrollable, continuous thiopental administration was effective for seizure mitigation. Conclusion  Neonatal seizures with WHS occur rarely. This is the first case report on seizures just after birth in a neonate with WHS.

Published
2016
Full Text
View/download PDF

42. Five cases of congenital chylothorax treated by intrapleural minocycline.

Author

Kaneko M, Kanai Y, Go H, Imamura T, Momoi N, and Hosoya M

Abstract

Minocycline pleurodesis was performed on five infants with congenital chylothorax in our institutions. They could not achieve sufficient efficacy though they had received other conservative therapies. Four of the five cases obtained reduction of pleural effusion using the minocycline pleurodesis. We concluded that minocycline pleurodesis is a safe and an effective technique for congenital chylothorax.

Published
2012
Full Text
View/download PDF

43. Modest maternal caffeine exposure affects developing embryonic cardiovascular function and growth.

Author

Momoi N, Tinney JP, Liu LJ, Elshershari H, Hoffmann PJ, Ralphe JC, Keller BB, and Tobita K

Subjects
Adenosine A1 Receptor Antagonists, Adenosine A2 Receptor Antagonists, Animals, Aorta drug effects, Aorta embryology, Blood Flow Velocity, Caffeine administration & dosage, Caffeine blood, Cardiovascular System diagnostic imaging, Cardiovascular System embryology, Cardiovascular System metabolism, Carotid Arteries drug effects, Carotid Arteries embryology, Central Nervous System Stimulants administration & dosage, Central Nervous System Stimulants blood, Crown-Rump Length, Echocardiography, Doppler, Pulsed, Embryo Loss chemically induced, Female, Fetal Growth Retardation chemically induced, Fetal Weight drug effects, Gestational Age, Injections, Subcutaneous, Mice, Pregnancy, RNA, Messenger metabolism, Receptor, Adenosine A1 metabolism, Receptor, Adenosine A2A genetics, Receptor, Adenosine A2A metabolism, Regional Blood Flow, Ultrasonography, Prenatal methods, Umbilical Arteries drug effects, Umbilical Arteries embryology, Xanthines pharmacology, Caffeine toxicity, Cardiovascular System drug effects, Central Nervous System Stimulants toxicity, Hemodynamics drug effects, Maternal Exposure
Abstract

Caffeine consumption during pregnancy is reported to increase the risk of in utero growth restriction and spontaneous abortion. In the present study, we tested the hypothesis that modest maternal caffeine exposure affects in utero developing embryonic cardiovascular (CV) function and growth without altering maternal hemodynamics. Caffeine (10 mg.kg(-1).day(-1) subcutaneous) was administered daily to pregnant CD-1 mice from embryonic days (EDs) 9.5 to 18.5 of a 21-day gestation. We assessed maternal and embryonic CV function at baseline and at peak maternal serum caffeine concentration using high-resolution echocardiography on EDs 9.5, 11.5, 13.5, and 18.5. Maternal caffeine exposure did not influence maternal body weight gain, maternal CV function, or embryo resorption. However, crown-rump length and body weight were reduced in maternal caffeine treated embryos by ED 18.5 (P < 0.05). At peak maternal serum caffeine concentration, embryonic carotid artery, dorsal aorta, and umbilical artery flows transiently decreased from baseline at ED 11.5 (P < 0.05). By ED 13.5, embryonic aortic and umbilical artery flows were insensitive to the peak maternal caffeine concentration; however, the carotid artery flow remained affected. By ED 18.5, baseline embryonic carotid artery flow increased and descending aortic flow decreased versus non-caffeine-exposed embryos. Maternal treatment with the adenosine A(2A) receptor inhibitor reproduced the embryonic hemodynamic effects of maternal caffeine exposure. Adenosine A(2A) receptor gene expression levels of ED 11.5 embryo and ED 18.5 uterus were decreased. Results suggest that modest maternal caffeine exposure has adverse effects on developing embryonic CV function and growth, possibly mediated via adenosine A(2A) receptor blockade.

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results