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Concerns over the ecological impacts of urban road runoff have increased, partly due to recent research into the harmful impacts of tire particles and their chemical leachates. This study aimed to help the community of researchers, regulators and policy advisers in scoping out the priority areas for further study. To improve our understanding of these issues an interdisciplinary, international network consisting of experts (United Kingdom, Norway, United States, Australia, South Korea, Finland, Austria, China and Canada) was formed. We synthesised the current state of the knowledge and highlighted priority research areas for tire particles (in their different forms) and their leachates. Ten priority research questions with high importance were identified under four themes (environmental presence and detection; chemicals of concern; biotic impacts; mitigation and regulation). The priority research questions include the importance of increasing the understanding of the fate and transport of these contaminants; better alignment of toxicity studies; obtaining the holistic understanding of the impacts; and risks they pose across different ecosystem services. These issues have to be addressed globally for a sustainable solution. We highlight how the establishment of the intergovernmental science-policy panel on chemicals, waste, and pollution prevention could further address these issues on a global level through coordinated knowledge transfer of car tire research and regulation. We hope that the outputs from this research paper will reduce scientific uncertainty in assessing and managing environmental risks from TP and their leachates and aid any potential future policy and regulatory development., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Inc.)

Tiragolumab, an anti-TIGIT antibody with an active IgG1κ Fc, demonstrated improved outcomes in the phase 2 CITYSCAPE trial (ClinicalTrials.gov: NCT03563716 ) when combined with atezolizumab (anti-PD-L1) versus atezolizumab alone 1 . However, there remains little consensus on the mechanism(s) of response with this combination 2 . Here we find that a high baseline of intratumoural macrophages and regulatory T cells is associated with better outcomes in patients treated with atezolizumab plus tiragolumab but not with atezolizumab alone. Serum sample analysis revealed that macrophage activation is associated with a clinical benefit in patients who received the combination treatment. In mouse tumour models, tiragolumab surrogate antibodies inflamed tumour-associated macrophages, monocytes and dendritic cells through Fcγ receptors (FcγR), in turn driving anti-tumour CD8 + T cells from an exhausted effector-like state to a more memory-like state. These results reveal a mechanism of action through which TIGIT checkpoint inhibitors can remodel immunosuppressive tumour microenvironments, and suggest that FcγR engagement is an important consideration in anti-TIGIT antibody development., (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)

The purpose of this study was to identify a characteristic elemental tyre fingerprint that can be utilised in atmospheric source apportionment calculations. Currently zinc is widely used as a single element tracer to quantify tyre wear, however several authors have highlighted issues with this approach. To overcome this, tyre rubber tread was digested and has been analysed for 25 elements by ICP-MS to generate a multielement profile. Additionally, to estimate the percentage of the tyre made up of inert fillers, thermogravimetric analysis was performed on a subset. Comparisons were made between passenger car and heavy goods vehicle tyre composition, and a subset of tyres had both tread and sidewall sampled for further comparison. 19 of the 25 elements were detected in the analysis. The mean mass fraction of zinc detected was 11.17 g/kg, consistent with previous estimates of 1% of the tyre mass. Aluminium, iron, and magnesium were found to be the next most abundant elements. Only one source profile for tyre wear exists in both the US and EU air pollution species profile databases, highlighting the need for more recent data with better coverage of tyre makes and models. This study provides data on new tyres which are currently operating on-road in Europe and is therefore relevant for ongoing atmospheric studies assessing the levels of tyre wear particles in urban areas., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier Ltd.)

Nitrogen dioxide (NO 2 ) and black carbon (BC) concentrations were measured inside London taxicabs across 40 work shifts in a real-world occupational study. The shifts were measured across five plug-in hybrid range-extender electric taxicabs (TXe City) and five diesel taxicabs (TX4 Diesel). The aim of this study was to characterise the impact of fuel and cabin design on professional drivers' air pollution exposures. Personal exposure was monitored using portable BC, NO 2 and GPS devices. A controlled study replicating a typical taxi drivers' route in central London was conducted. Simultaneous inside and outside BC concentrations were measured to assess infiltration rates. The drivers were instructed to keep the BC devices with them at all times, providing a comparison of exposures at work and outside of work. The driver's average BC and NO 2 exposure while working was nearly twice as high for diesel taxicab drivers (6.8 ± 7.0 μg/m³, 101.9 ± 87.8 μg/m³) compared with electric drivers (3.6 ± 4.9 μg/m³, 55.3 ± 53.0 μg/m³, respectively). The exposure to BC while not working was 1.6 μg/m³ for diesel drivers and 1.1 μg/m³ for electric drivers, highlighting the very high exposures experienced by this occupational sector. The analysis of vehicle type on BC concentrations showed that the airtight cabin design and presence of an in-built filter in the electric TXe City reduced the exposure to BC substantially; indoor to outdoor ratios being 0.63 on the electric taxi compared to 0.99 on the diesel taxi with recirculate ventilation mode off and 0.07 to 0.44 with recirculate on. These findings provide important evidence for occupational health of professional drivers through exposure reduction measures in vehicle design., (Copyright © 2021 Elsevier Inc. All rights reserved.)