Search

Your search keyword '"Modoni, Sergio"' showing total 14 results
Start Over Author "Modoni, Sergio" Search Limiters Full Text
14 results on '"Modoni, Sergio"'

2. Association of CSF and PET markers of neurodegeneration with electroclinical progression in Lafora disease.

Author

d'Orsi, Giuseppe, Farolfi, Andrea, Muccioli, Lorenzo, Palumbo, Orazio, Palumbo, Pietro, Modoni, Sergio, Allegri, Vincenzo, Garibotto, Valentina, Di Claudio, Maria Teresa, Di Muro, Ester, Benvenuto, Mario, Bisulli, Francesca, and Carella, Massimo

Subjects
EPILEPSY, DISEASE progression, SEIZURES (Medicine), MYOCLONUS, TEMPORAL lobe, NEURODEGENERATION, STATUS epilepticus
Abstract

Purpose: To evaluate the electro-clinical features in association with laboratory and instrumental correlates of neurodegeneration to detect the progression of Lafora disease (LD). Methods: We investigated the electro-clinical longitudinal data and CSF Ab42, p-tau181 and t-tauAg, amyloid, and 18F-FDG PET of five unrelated LD families. Results: Three progressive electro-clinical stages were identified. The early phase was characterized by rare, generalized tonic-clonic and focal visual seizures, followed by the occurrence of myoclonus after a period ranging from 2 to 12 months. The intermediate stage, usually occurring 2 years after the onset of epilepsy, is characterized by a worsening of epilepsy and myoclonus associated with progressive dementia and cerebellar signs. Finally, the late stage, evolving after a mean period of 7 ± 1.41 years from the onset of the disease, was characterized by gait ataxia resulting in bedriddenness, severe dementia, daily/pluri-daily myoclonus, drug-resistant epilepsy, clusters of seizures or status epilepticus, and medical complications. Amyloid (CSF Ab42, amyloid PET) and neurodegenerative (CSF p-tau181 and t-tauAg, FDG-PET) biomarkers indicate a pattern of cognitive impairment of the non-Alzheimer's disease type. A total of 80% of the LD patients showed more severe hypometabolism in the second FDG-PET scan compared to the first scan performed in a lower phase; the lateral temporal lobe and the thalamus hypometabolism were associated with the presence of intermediate or late phase. Conclusions: Three electroclinical and 18F-FDG PET evolutive stages are useful biomarkers for the progression of LD and could help to evaluate the effcacy of new disease-modifying treatments. The combination of traditional CSF biomarkers improves the diagnostic accuracy of cognitive decline in LD patients, indicating a cognitive impairment of the non-Alzheimer's disease type. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

3. Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study

Author

Albano, Domenico, Bertagna, Francesco, Alongi, Pierpaolo, Baldari, Sergio, Baldoncini, Alfonso, Bartolomei, Mirco, Boccaletto, Franco, Boero, Michele, Borsatti, Eugenio, Bruno, Andrea, Burroni, Luca, Capoccetti, Francesca, Castellani, Massimo, Cervino, Anna Rita, Chierichetti, Franca, Ciarmiello, Andrea, Corso, Angelo, Cuocolo, Alberto, De Rimini, Maria Luisa, Deandreis, Desiree’, Dottorini, Massimo Eugenio, Esposito, Filomena, Farsad, Mohsen, Gasparini, Massimo, Grana, Chiara Maria, Gregianin, Michele, Guerra, Luca, Loreti, Fabio, Lupi, Andrea, Martino, Gianluigi, Milan, Elisa, Modoni, Sergio, Morbelli, Silvia, Muni, Alfredo, Nicolai, Emanuele, Palumbo, Barbara, Papa, Sergio, Papaleo, Alberto, Pellerito, Riccardo, Poti, Carlo, Romano, Pasquale, Rossetti, Claudio, Rossini, Pierluigi, Rubini, Giuseppe, Ruffini, Livia, Sacchetti, Gianmauro, Savelli, Giordano, Schiavariello, Saverio, Sciagrà, Roberto, Sciuto, Rosa, Seregni, Ettore, Sestini, Stelvio, Sicolo, Michele, Spanu, Angela, Storto, Giovanni, Balducci, Massimo Tosti, Trifirò, Giuseppe, Versari, Annibale, Vignati, Alberto, Volterrani, Duccio, Calcagni, Maria Lucia, Marzola, Maria Cristina, Garufo, Antonio, Evangelista, Laura, Maroldi, Roberto, Schillaci, Orazio, Giubbini, Raffaele, Bonacina, M., Laudicella, R., Spallino, M., Palucci, A., Cuzzocrea, M., Donner, M., Maurea, S., Ceci, F., Dei Rossi, F., Tranfaglia, B., Sartorello, A., Gandolfo, P., Buschiazzo, A., Scarale, A., Kirienko, M., Merenda, N., Nappi, A. G., Durmo, R., Vellani, C., Ceriani, V., Albano, D, Bertagna, F, Alongi, P, Baldari, S, Baldoncini, A, Bartolomei, M, Boccaletto, F, Boero, M, Borsatti, E, Bruno, A, Burroni, L, Capoccetti, F, Castellani, M, Cervino, A, Chierichetti, F, Ciarmiello, A, Corso, A, Cuocolo, A, De Rimini, M, Deandreis, D, Dottorini, M, Esposito, F, Farsad, M, Gasparini, M, Grana, C, Gregianin, M, Guerra, L, Loreti, F, Lupi, A, Martino, G, Milan, E, Modoni, S, Morbelli, S, Muni, A, Nicolai, E, Palumbo, B, Papa, S, Papaleo, A, Pellerito, R, Poti, C, Romano, P, Rossetti, C, Rossini, P, Rubini, G, Ruffini, L, Sacchetti, G, Savelli, G, Schiavariello, S, Sciagra, R, Sciuto, R, Seregni, E, Sestini, S, Sicolo, M, Spanu, A, Storto, G, Balducci, M, Trifiro, G, Versari, A, Vignati, A, Volterrani, D, Calcagni, M, Marzola, M, Garufo, A, Evangelista, L, Maroldi, R, Schillaci, O, Giubbini, R, Bonacina, M, Laudicella, R, Spallino, M, Palucci, A, Cuzzocrea, M, Donner, M, Maurea, S, Ceci, F, Dei Rossi, F, Tranfaglia, B, Sartorello, A, Gandolfo, P, Buschiazzo, A, Scarale, A, Kirienko, M, Merenda, N, Nappi, A, Durmo, R, Vellani, C, Ceriani, V, Albano, Domenico, Bertagna, Francesco, Alongi, Pierpaolo, Baldari, Sergio, Baldoncini, Alfonso, Bartolomei, Mirco, Boccaletto, Franco, Boero, Michele, Borsatti, Eugenio, Bruno, Andrea, Burroni, Luca, Capoccetti, Francesca, Castellani, Massimo, Cervino, Anna Rita, Chierichetti, Franca, Ciarmiello, Andrea, Corso, Angelo, Cuocolo, Alberto, De Rimini, Maria Luisa, Deandreis, Desiree', Dottorini, Massimo Eugenio, Esposito, Filomena, Farsad, Mohsen, Gasparini, Massimo, Grana, Chiara Maria, Gregianin, Michele, Guerra, Luca, Loreti, Fabio, Lupi, Andrea, Martino, Gianluigi, Milan, Elisa, Modoni, Sergio, Morbelli, Silvia, Muni, Alfredo, Nicolai, Emanuele, Palumbo, Barbara, Papa, Sergio, Papaleo, Alberto, Pellerito, Riccardo, Poti, Carlo, Romano, Pasquale, Rossetti, Claudio, Rossini, Pierluigi, Rubini, Giuseppe, Ruffini, Livia, Sacchetti, Gianmauro, Savelli, Giordano, Schiavariello, Saverio, Sciagrà, Roberto, Sciuto, Rosa, Seregni, Ettore, Sestini, Stelvio, Sicolo, Michele, Spanu, Angela, Storto, Giovanni, Balducci, Massimo Tosti, Trifirò, Giuseppe, Versari, Annibale, Vignati, Alberto, Volterrani, Duccio, Calcagni, Maria Lucia, Marzola, Maria Cristina, Garufo, Antonio, Evangelista, Laura, Maroldi, Roberto, Schillaci, Orazio, and Giubbini, Raffaele

Subjects
Lung Diseases, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Asymptomatic, Incidental finding, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Pandemic, Prevalence, medicine, Humans, Radiology, Nuclear Medicine and imaging, 18F-FDG PET/CT, COVID-19, Incidental findings, Interstitial pneumonia, SARS-CoV-2, Italy, Pandemics, Retrospective Studies, Lung Diseases, Interstitial, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Lung, medicine.diagnostic_test, business.industry, F-FDG PET/CT, Interstitial lung disease, Retrospective cohort study, General Medicine, medicine.disease, Pneumonia, medicine.anatomical_structure, Radiology Nuclear Medicine and imaging, Positron emission tomography, Radiology, medicine.symptom, Interstitial, business
Abstract

Purpose To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p Conclusions A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.

Published
2021

4. Comparative Evaluation of Recombinant Human Thyrotropin-Stimulated Thyroglobulin Levels, 131I Whole-Body Scintigraphy, and Neck Ultrasonography in the Follow-Up of Patients with Papillary Thyroid Microcarcinoma Who Have Not Undergone Radioiodine Therapy

Author

Torlontano, Massimo, Crocetti, Umberto, Augello, Giovanni, D’Aloiso, Leonardo, Bonfitto, Nazario, Varraso, Antonio, Dicembrino, Franca, Modoni, Sergio, Frusciante, Vincenzo, Di Giorgio, Anna, Bruno, Rocco, Filetti, Sebastiano, and Trischitta, Vincenzo

Published
2006

5. Multiple Skeletal Muscle Metastases from Colon Carcinoma Preceded by Paraneoplastic Dermatomyositis

Author

Landriscina, Matteo, Gerardi, Assunta Maria Teresa, Fersini, Alberto, Modoni, Sergio, Stoppino, Luca Pio, Macarini, Luca, Sanguedolce, Francesca, Bufo, Pantaleo, and Neri, Vincenzo

Subjects
Article Subject
Abstract

Skeletal muscle metastases are very rare events in colorectal carcinoma. By contrast, dermatomyositis is an idiopathic inflammatory myopathy with characteristic cutaneous manifestations and a well-recognized association with several human malignancies and, among others, colorectal cancer. Here, we report the case of a 71-year-old woman with paraneoplastic dermatomyositis followed by the development of a metastatic colon cancer. Interestingly, this patient developed multiple skeletal metastases which were preceded by the worsening of systemic symptoms of dermatomyositis. This observation suggests that, while muscle tissue is usually resistant to the development of tumor metastases, the inflammatory and immune response which characterizes and boosts paraneoplastic myopathy may represent a favorable soil for tumor cell invasion and metastasization to skeletal muscles.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results