Search

Your search keyword '"Mitchell, Jerry R."' showing total 14 results
Start Over Author "Mitchell, Jerry R." Search Limiters Full Text
14 results on '"Mitchell, Jerry R."'

2. Propylbutyldopamine.

Author

TAYLOR, ADDISON A., FENNELL, WILLIAM H., RUUD, CHRISTOPHER O., POOL, JAMES L., NELSON, EDWARD B., GINOS, JAMES Z., and MITCHELL, JERRY R.

Published
1984

6. Hepatic necrosis caused by furosemide

Author

MITCHELL, JERRY R., POTTER, WILLIAM Z., HINSON, JACK A., and JOLLOW, DAVID J.

Abstract

FUROSEMIDE (frusemide) is a diuretic drug frequently used in the treatment of many cardiovascular and renal diseases. Its use is contraindicated in pregnancy because of its recognised teratogenic potential1. The drug also has been reported to potentiate renal injury when used in combination with cephaloridine2,3. Here we report that this widely prescribed therapeutic agent is converted by microsomal enzymes in the liver of mice and humans to a reactive arylating metabolite that produces massive hepatic necrosis in mice.

Published
1974
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results