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9 results on '"Mitani, Akitoshi"'

1. CD69 Signaling in Eosinophils Induces IL-10 Production and Apoptosis via the Erk1/2 and JNK Pathways, Respectively

Author

Bui, Dan Van, primary, Nguyen, Linh Manh, additional, Kanda, Akira, additional, Chu, Hanh Hong, additional, Thi Le, Nhi Kieu, additional, Yun, Yasutaka, additional, Kobayashi, Yoshiki, additional, Suzuki, Kensuke, additional, Mitani, Akitoshi, additional, Shimamura, Akihiro, additional, Fukui, Kenta, additional, Sawada, Shunsuke, additional, Dombrowicz, David, additional, and Iwai, Hiroshi, additional

Published
2024
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3. Inoculation of lymphocytes from young mice prevents progression of age-related hearing loss in a senescence-associated mouse model

Author

Mitani, Akitoshi, primary, Iwai, Hiroshi, additional, Inaba, Muneo, additional, Van Bui, Dan, additional, Miwa, Toru, additional, Nguyen, Linh Manh, additional, Hanh, Chu Hong, additional, Sakagami, Tomofumi, additional, Suzuki, Kensuke, additional, Kobayashi, Yoshiki, additional, Yun, Yasutaka, additional, Sugita, Yuuki, additional, and Kanda, Akira, additional

Published
2023
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4. The Neutralization of the Eosinophil Peroxidase Antibody Accelerates Eosinophilic Mucin Decomposition.

Author

Kobayashi, Yoshiki, Chu, Hanh Hong, Bui, Dan Van, Yun, Yasutaka, Nguyen, Linh Manh, Mitani, Akitoshi, Suzuki, Kensuke, Asako, Mikiya, Kanda, Akira, and Iwai, Hiroshi

Subjects
MUCINS, IMMUNOGLOBULINS, MONOCLONAL antibodies, EOSINOPHILS, PEROXIDASE, ENZYME-linked immunosorbent assay, ASTHMA
Abstract

Eosinophilic airway inflammation, complicated by bronchial asthma and eosinophilic chronic rhinosinusitis (ECRS), is difficult to treat. The disease may become refractory when eosinophilic mucin associated with eosinophil peroxidase (EPX) and autoantibodies fills in the paranasal sinus and small airway. This study investigated the functional role of an anti-EPX antibody in eosinophilic mucin of ECRS in eosinophilic airway inflammation. Eosinophilic mucin was obtained from patients with ECRS. The effects of the anti-EPX antibody on dsDNA release from eosinophils and eosinophilic mucin decomposition were evaluated. Immunofluorescence or enzyme-linked immunosorbent assays were performed to detect the anti-EPX antibody and its supernatant and serum levels in eosinophilic mucin, respectively. The serum levels of the anti-EPX antibody were positively correlated with sinus computed tomography score and fractionated exhaled nitrogen oxide. Patients with refractory ECRS had higher serum levels of the anti-EPX antibody than those without. However, dupilumab treatment decreased the serum levels of the anti-EPX antibody. Immunoglobulins (Igs) in the immunoprecipitate of mucin supernatants enhanced dsDNA release from eosinophils, whereas the neutralization of Igs against EPX stopped dsDNA release. Furthermore, EPX antibody neutralization accelerated mucin decomposition and restored corticosteroid sensitivity. Taken together, the anti-EPX antibody may be involved in the formulation of eosinophilic mucin and be used as a clinical marker and therapeutic target for intractable eosinophilic airway inflammation. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Efficacy of Combination Therapy with Lenvatinib and Radioactive Iodine in Thyroid Cancer Preclinical Model

Author

Suzuki, Kensuke, primary, Iwai, Hiroshi, additional, Utsunomiya, Keita, additional, Kono, Yumiko, additional, Watabe, Tadashi, additional, Kobayashi, Yoshiki, additional, Bui, Dan Van, additional, Sawada, Shunsuke, additional, Yun, Yasutaka, additional, Mitani, Akitoshi, additional, Fukui, Kenta, additional, Sakai, Haruka, additional, Chu, Hanh Hong, additional, Linh, Nguyen Manh, additional, Tanigawa, Noboru, additional, and Kanda, Akira, additional

Published
2022
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7. CCL4 Functions as a Biomarker of Type 2 Airway Inflammation

Author

Kobayashi, Yoshiki, primary, Chu, Hanh Hong, additional, Kanda, Akira, additional, Yun, Yasutaka, additional, Shimono, Masami, additional, Nguyen, Linh Manh, additional, Mitani, Akitoshi, additional, Suzuki, Kensuke, additional, Asako, Mikiya, additional, and Iwai, Hiroshi, additional

Published
2022
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9. Corrigendum to “The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions” [Allergol Int 70 (2021) 9–18]

Author

Kanda, Akira, primary, Yun, Yasutaka, additional, Van Bui, Dan, additional, Nguyen, Linh Manh, additional, Kobayashi, Yoshiki, additional, Suzuki, Kensuke, additional, Mitani, Akitoshi, additional, Sawada, Shunsuke, additional, Hamada, Satoko, additional, Asako, Mikiya, additional, and Iwai, Hiroshi, additional

Published
2021
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