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2. Screening for Systemic Diseases Associated with Dental Self-Care in Japanese Adolescents.

Author

Abe, Masanobu, Mitani, Akihisa, Hoshi, Kazuto, and Yanagimoto, Shintaro

Subjects
*GINGIVAL hemorrhage, *JAPANESE people, *LOGISTIC regression analysis, *ATOPIC dermatitis, *ORAL hygiene
Abstract

Background: Toothbrushing is important for maintaining oral health and preventing periodontal disease. However, the association between toothbrushing and systemic diseases remains unclear in adolescence. In this study, the association between dental self-care (frequency and duration of toothbrushing) and systemic diseases/disorders in adolescents was examined. Methods: We conducted a retrospective review of mandatory medical questionnaires administered during legally mandated freshman medical checkups between 2017 and 2019 at the University of Tokyo, Japan. Out of 9376 total responses, 9098 cases involving individuals under the age of 20 were included in the analysis. Respondents were classified into three groups based on their daily toothbrushing frequency: "1 time or less", "twice", and "3 times or more". For the duration of each toothbrushing session, they were classified into three groups: "1 min or less", "2–3 min", and "4 min or more". A statistical analysis was performed by Pearson's χ2 test and multinomial logistic regression analysis. Results: Regarding frequency of daily toothbrushing: The χ2 test showed no significant relationship between frequency of toothbrushing and 17 systemic diseases/disorders. A multivariate analysis found that gingival bleeding and sex were independent factors. The risk of gingival bleeding decreased dramatically with increased frequency of toothbrushing (odds ratio (OR): 0.428; 95% confidence interval (CI), 0.366–0.501; p < 0.001). Regarding the amount of time spent on toothbrushing: The χ2 test showed atopic dermatitis and arrhythmia were significantly associated with the duration of toothbrushing (p = 0.032 and p = 0.016, respectively). In the multivariate analysis, atopic dermatitis, gingival bleeding, and sex were independent factors regarding the duration of toothbrushing; longer brushing time was associated with a lower risk of atopic dermatitis (OR: 0.731, 95% CI: 0.578–0.924, p = 0.009) and a lower risk of gingival bleeding (OR: 0.643, 95% CI: 0.567–0.729, p < 0.001). Conclusions: Dental self-care was most strongly associated with gingival bleeding, while the risk of atopic dermatitis was found to increase with shorter toothbrushing times. The results suggest that dental self-care during adolescence is important not only for oral health but also for general health. [ABSTRACT FROM AUTHOR]

Published
2024
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9. The Link between Periodontal Disease and Asthma: How Do These Two Diseases Affect Each Other?

Author

Tamiya, Hiroyuki, Abe, Masanobu, Nagase, Takahide, and Mitani, Akihisa

Subjects
PERIODONTAL disease, WHEEZE, LITERATURE reviews, RESPIRATORY diseases, ASTHMA, COUGH, ORAL hygiene
Abstract

A growing body of evidence suggests that the effects of poor oral hygiene extend beyond the oral cavity and are associated with a variety of systemic diseases, including asthma. Asthma, which results in symptoms of cough, wheezing, and dyspnoea, and is characterized by airflow limitation with variability and (partial or complete) reversibility, is amongst the most prevalent respiratory diseases with approximately 262 million patients worldwide, and its prevalence and disease burden is on the increase. While asthma can occur at a young age, it can also develop later in life and affects a variety of age groups. Both of these diseases have a chronic course, and various researchers have suggested a link between the two. In this article, we aim to provide a literature review focusing on the association between the two diseases. The results demonstrate that medications (primarily, inhaler medicine), hypoxia induced by asthma, and the breathing behaviour of patients potentially trigger periodontal disease. In contrast, oral periodontopathogenic microorganisms and the inflammatory mediators produced by them may be involved in the onset and/or exacerbation of asthma. Common contributing factors, such as smoking, gastro-oesophageal reflux, and type-2 inflammation, should also be considered when evaluating the relationship between the two diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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11. PRELP Regulates Cell–Cell Adhesion and EMT and Inhibits Retinoblastoma Progression

Author

Hopkins, Jack, primary, Asada, Ken, additional, Leung, Alex, additional, Papadaki, Vasiliki, additional, Davaapil, Hongorzul, additional, Morrison, Matthew, additional, Orita, Tomoko, additional, Sekido, Ryohei, additional, Kosuge, Hirofumi, additional, Reddy, M. Ashwin, additional, Kimura, Kazuhiro, additional, Mitani, Akihisa, additional, Tsumoto, Kouhei, additional, Hamamoto, Ryuji, additional, Sagoo, Mandeep S., additional, and Ohnuma, Shin-ichi, additional

Published
2022
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16. The Japanese Herbal (Kampo) Medicine Hochuekkito Attenuates Lung Inflammation in Lung Emphysema

Author

Isago, Hideaki, primary, Mitani, Akihisa, additional, Kohno, Shiho, additional, Nagoshi, Saki, additional, Ishimori, Taro, additional, Saito, Minako, additional, Tamiya, Hiroyuki, additional, Miyashita, Naoya, additional, Ishii, Takashi, additional, Matsuzaki, Hirotaka, additional, Yatomi, Yutaka, additional, Nagase, Takahide, additional, and Jo, Taisuke, additional

Published
2021
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17. Two Secreted Proteoglycans, Activators of Urothelial Cell–Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression

Author

Papadaki, Vasiliki, primary, Asada, Ken, additional, Watson, Julie K., additional, Tamura, Toshiya, additional, Leung, Alex, additional, Hopkins, Jack, additional, Dellett, Margaret, additional, Sasai, Noriaki, additional, Davaapil, Hongorzul, additional, Nik-Zainal, Serena, additional, Longbottom, Rebecca, additional, Nakakido, Makoto, additional, Torii, Ryo, additional, Veerakumarasivam, Abhi, additional, Kaneko, Syuzo, additional, Sagoo, Mandeep S., additional, Murphy, Gillian, additional, Mitani, Akihisa, additional, Tsumoto, Kohei, additional, Kelly, John D., additional, Hamamoto, Ryuji, additional, and Ohnuma, Shin-ichi, additional

Published
2020
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23. Naftopidil reduced the proliferation of lung fibroblasts and bleomycin‐induced lung fibrosis in mice

Author

Urushiyama, Hirokazu, primary, Terasaki, Yasuhiro, additional, Nagasaka, Shinya, additional, Kokuho, Nariaki, additional, Endo, Youko, additional, Terasaki, Mika, additional, Kunugi, Shinobu, additional, Makita, Kosuke, additional, Isago, Hideaki, additional, Hosoki, Keisuke, additional, Souma, Kunihiko, additional, Ishii, Takashi, additional, Matsuzaki, Hirotaka, additional, Hiraishi, Yoshihisa, additional, Mikami, Yu, additional, Noguchi, Satoshi, additional, Tamiya, Hiroyuki, additional, Mitani, Akihisa, additional, Yamauchi, Yasuhiro, additional, Shimizu, Akira, additional, and Nagase, Takahide, additional

Published
2019
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24. Reduction in exacerbation of COPD in patients of advanced age using the Japanese Kampo medicine Dai-kenchu-to: a retrospective cohort study

Author

Jo, Taisuke, primary, Michihata, Nobuaki, additional, Yamana, Hayato, additional, Sasabuchi, Yusuke, additional, Matsui, Hiroki, additional, Urushiyama, Hirokazu, additional, Mitani, Akihisa, additional, Yamauchi, Yasuhiro, additional, Fushimi, Kiyohide, additional, Nagase, Takahide, additional, and Yasunaga, Hideo, additional

Published
2018
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25. Reduction in exacerbation of COPD in patients of advanced age using the Japanese Kampo medicine Dai-kenchu-to: a retrospective cohort study

Author

Jo,Taisuke, Michihata,Nobuaki, Yamana,Hayato, Sasabuchi,Yusuke, Matsui,Hiroki, Urushiyama,Hirokazu, Mitani,Akihisa, Yamauchi,Yasuhiro, Fushimi,Kiyohide, Nagase,Takahide, Yasunaga,Hideo, Jo,Taisuke, Michihata,Nobuaki, Yamana,Hayato, Sasabuchi,Yusuke, Matsui,Hiroki, Urushiyama,Hirokazu, Mitani,Akihisa, Yamauchi,Yasuhiro, Fushimi,Kiyohide, Nagase,Takahide, and Yasunaga,Hideo

Abstract

Taisuke Jo,1,2 Nobuaki Michihata,1 Hayato Yamana,1 Yusuke Sasabuchi,3 Hiroki Matsui,4 Hirokazu Urushiyama,2 Akihisa Mitani,2 Yasuhiro Yamauchi,2 Kiyohide Fushimi,5 Takahide Nagase,2 Hideo Yasunaga4 1Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 2Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 3Data Science Center, Jichi Medical University, Tochigi, Japan; 4Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan; 5Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan Purpose: Patients with symptomatic COPD are recommended to use inhaled bronchodilators containing long-acting muscarinic receptor antagonists (LAMAs). However, bronchodilators may cause gastrointestinal adverse effects due to anticholinergic reactions, especially in advanced-age patients with COPD. Dai-kenchu-to (TU-100, Da Jian Zhong Tang in Chinese) is the most frequently prescribed Japanese herbal Kampo medicine and is often prescribed to control abdominal bloating and constipation. The purpose of this study was to evaluate the role of Dai-kenchu-to as a supportive therapy in advanced-age patients with COPD. Patients and methods: We used the Japanese Diagnosis Procedure Combination inpatient database and identified patients aged ≥75 years who were hospitalized for COPD exacerbation. We then compared the risk of re-hospitalization for COPD exacerbation or death between patients with and without Dai-kenchu-to using 1-to-4 propensity score matching. A Cox proportional hazards model was used to compare the two groups. We performed subgroup analyses for patients with and without LAMA therapy. Results: Patients treated with Dai-kenchu-to had a significantly lower risk of re-hospitalization or death after discharge; the HR was 0.82 (95% CI, 0.67

Published
2018

26. Additional file 3: Figure S2. of The incidence and risk factors of asymptomatic primary spontaneous pneumothorax detected during health check-ups

Author

Mitani, Akihisa, Yukichika Hakamata, Hosoi, Megumi, Horie, Masafumi, Murano, Yoko, Saito, Akira, Yanagimoto, Shintaro, Tsuji, Shoji, Yamamoto, Kazuhiko, and Nagase, Takahide

Subjects
heterocyclic compounds, macromolecular substances, respiratory system, eye diseases
Abstract

The lung collapse rate and therapy in each case. The severity of asymptomatic PSP was not correlated with the prognosis. (PPT 255 kb)

Published
2017
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27. Additional file 1: Figure S1. of The incidence and risk factors of asymptomatic primary spontaneous pneumothorax detected during health check-ups

Author

Mitani, Akihisa, Yukichika Hakamata, Hosoi, Megumi, Horie, Masafumi, Murano, Yoko, Saito, Akira, Yanagimoto, Shintaro, Tsuji, Shoji, Yamamoto, Kazuhiko, and Nagase, Takahide

Abstract

The average body height at each age. During the 5Â years between the ages of 18 and 23Â years, mean body height increased both in male and female students. During the next 5Â years, however, there was little to no change in mean body height. (PPT 301 kb)

Published
2017
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28. Additional file 2: Table S1. of The incidence and risk factors of asymptomatic primary spontaneous pneumothorax detected during health check-ups

Author

Mitani, Akihisa, Yukichika Hakamata, Hosoi, Megumi, Horie, Masafumi, Murano, Yoko, Saito, Akira, Yanagimoto, Shintaro, Tsuji, Shoji, Yamamoto, Kazuhiko, and Nagase, Takahide

Subjects
carbohydrates (lipids), parasitic diseases, education, food and beverages, eye diseases
Abstract

Biochemical examinations of students with asymptomatic PSP (APSP). There were no differences in biochemical test results between the asymptomatic PSP group and all students. (DOCX 16 kb)

Published
2017
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30. Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses

Author

Urushiyama, Hirokazu, primary, Jo, Taisuke, additional, Yasunaga, Hideo, additional, Michihata, Nobuaki, additional, Yamana, Hayato, additional, Matsui, Hiroki, additional, Hasegawa, Wakae, additional, Hiraishi, Yoshihisa, additional, Mitani, Akihisa, additional, Fushimi, Kiyohide, additional, Nagase, Takahide, additional, and Yamauchi, Yasuhiro, additional

Published
2018
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31. Oral fluorouracil vs vinorelbine plus cisplatin as adjuvant chemotherapy for stage II-IIIA non-small cell lung cancer: Propensity score-matched and instrumental variable analyses

Author

Urushiyama, Hirokazu, primary, Jo, Taisuke, additional, Yasunaga, Hideo, additional, Michihata, Nobuaki, additional, Matsui, Hiroki, additional, Hasegawa, Wakae, additional, Takeshima, Hideyuki, additional, Sakamoto, Yukiyo, additional, Hiraishi, Yoshihisa, additional, Mitani, Akihisa, additional, Fushimi, Kiyohide, additional, Nagase, Takahide, additional, and Yamauchi, Yasuhiro, additional

Published
2018
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32. Acute Arterial Thrombosis during Postoperative Adjuvant Cisplatin-based Chemotherapy for Completely Resected Lung Adenocarcinoma

Author

Sato, Chihiro, primary, Okuda, Kenichi, additional, Tamiya, Hiroyuki, additional, Yamamoto, Kota, additional, Hoshina, Katsuyuki, additional, Narumoto, Osamu, additional, Urushiyama, Hirokazu, additional, Noguchi, Satoshi, additional, Amano, Yosuke, additional, Watanabe, Kosuke, additional, Mitani, Akihisa, additional, Kage, Hidenori, additional, Tanaka, Goh, additional, Yamauchi, Yasuhiro, additional, Takai, Daiya, additional, and Nagase, Takahide, additional

Published
2018
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34. Adjuvant chemotherapy versus chemoradiotherapy for small cell lung cancer with lymph node metastasis: a retrospective observational study with use of a national database in Japan

Author

Urushiyama, Hirokazu, primary, Jo, Taisuke, additional, Yasunaga, Hideo, additional, Yamauchi, Yasuhiro, additional, Matsui, Hiroki, additional, Hasegawa, Wakae, additional, Takeshima, Hideyuki, additional, Hiraishi, Yoshihisa, additional, Mitani, Akihisa, additional, Fushimi, Kiyohide, additional, and Nagase, Takahide, additional

Published
2017
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35. TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts

Author

Noguchi, Satoshi, primary, Saito, Akira, additional, Mikami, Yu, additional, Urushiyama, Hirokazu, additional, Horie, Masafumi, additional, Matsuzaki, Hirotaka, additional, Takeshima, Hideyuki, additional, Makita, Kosuke, additional, Miyashita, Naoya, additional, Mitani, Akihisa, additional, Jo, Taisuke, additional, Yamauchi, Yasuhiro, additional, Terasaki, Yasuhiro, additional, and Nagase, Takahide, additional

Published
2017
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38. The incidence and risk factors of asymptomatic primary spontaneous pneumothorax detected during health check-ups.

Author

Akihisa Mitani, Yukichika Hakamata, Megumi Hosoi, Masafumi Horie, Yoko Murano, Akira Saito, Shintaro Yanagimoto, Shoji Tsuji, Kazuhiko Yamamoto, Takahide Nagase, Mitani, Akihisa, Hakamata, Yukichika, Hosoi, Megumi, Horie, Masafumi, Murano, Yoko, Saito, Akira, Yanagimoto, Shintaro, Tsuji, Shoji, Yamamoto, Kazuhiko, and Nagase, Takahide

Subjects
PNEUMOTHORAX, DYSPNEA, LUNG diseases, PNEUMONIA, CHEST pain
Abstract

Background: Patients with primary spontaneous pneumothorax (PSP) usually complain of sudden-onset dyspnea and pleuritic chest pain. However, asymptomatic PSP has been incidentally detected on chest X-rays. In this study, we analyzed the incidence, characteristics, risk factors, and prognosis of asymptomatic PSP detected during regular medical check-ups in university students.Methods: In this study, 101,709 chest X-rays were performed during medical check-ups for students at the University of Tokyo between April 2011 and March 2016. Among them, 43 cases of asymptomatic PSP (0.042%) were detected. We calculated the lung collapse rate of pneumothorax using Kircher's method. We also analyzed risk factors associated with asymptomatic PSP using characteristics inspected in medical check-ups.Results: The incidence of asymptomatic PSP was significantly higher in men than in women (0.050% vs 0.018%). Multivariate analysis revealed an association of younger age, greater height, lower body mass index, and greater height growth per year with an increased risk of asymptomatic PSP in male students. Mild lung collapse (<10%) was present in 22 of 43 students with asymptomatic PSP; among these, eight students eventually underwent an invasive therapy.Conclusions: The prevalence of asymptomatic PSP among university students was as high as 0.042%. In addition to known risk factors for conventional PSP, greater height growth was a risk factor for asymptomatic PSP. Careful follow-up is very important because a considerable number of patients with mild lung collapse eventually require an invasive medical procedure. [ABSTRACT FROM AUTHOR]

Published
2017
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39. Adjuvant chemotherapy versus chemoradiotherapy for small cell lung cancer with lymph node metastasis: a retrospective observational study with use of a national database in Japan.

Author

Hirokazu Urushiyama, Taisuke Jo, Hideo Yasunaga, Yasuhiro Yamauchi, Hiroki Matsui, Wakae Hasegawa, Hideyuki Takeshima, Yoshihisa Hiraishi, Akihisa Mitani, Kiyohide Fushimi, Takahide Nagase, Urushiyama, Hirokazu, Jo, Taisuke, Yasunaga, Hideo, Yamauchi, Yasuhiro, Matsui, Hiroki, Hasegawa, Wakae, Takeshima, Hideyuki, Hiraishi, Yoshihisa, and Mitani, Akihisa

Subjects
CANCER chemotherapy, CHEMORADIOTHERAPY, SMALL cell lung cancer, LYMPH node cancer, METASTASIS, REGRESSION analysis, COMBINED modality therapy, LUNG cancer, LYMPH nodes, PROGNOSIS, TUMOR classification, TREATMENT effectiveness, PROPORTIONAL hazards models
Abstract

Background: The optimal postoperative treatment strategy for small cell lung cancer (SCLC) remains unclear, especially in patients with lymph node metastasis. We aimed to compare the outcomes of patients with SCLC and lymph node metastasis treated with postoperative adjuvant chemotherapy or chemoradiotherapy.Methods: We retrospectively collected data on patients with postoperative SCLC diagnosed with N1 and N2 lymph node metastasis from the Diagnosis Procedure Combination database in Japan, between July 2010 and March 2015. We extracted data on patient age, sex, comorbidities, and TNM classification at lung surgery; operative procedures, chemotherapy drugs, and radiotherapy during hospitalization; and discharge status. Recurrence-free survival was compared between the chemotherapy and chemoradiotherapy groups using multivariable Cox regression analysis.Results: Median recurrence-free survival was 1146 days (95% confidence interval [CI], 885-1407) in the chemotherapy group (n = 489) and 873 days (95% CI, 464-1282) in the chemoradiotherapy group (n = 75). There was no significant difference between these after adjusting for patient backgrounds (hazard ratio, 1.29; 95% CI, 0.91-1.84).Conclusions: There was no significant difference in recurrence-free survival between patients with SCLC and N1-2 lymph node metastasis treated with postoperative adjuvant chemotherapy and chemoradiotherapy. Further randomized clinical trials are needed to address this issue. [ABSTRACT FROM AUTHOR]

Published
2017
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40. Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ

Author

Makita, Ryosuke, primary, Uchijima, Yasunobu, additional, Nishiyama, Koichi, additional, Amano, Tomokazu, additional, Chen, Qin, additional, Takeuchi, Takumi, additional, Mitani, Akihisa, additional, Nagase, Takahide, additional, Yatomi, Yutaka, additional, Aburatani, Hiroyuki, additional, Nakagawa, Osamu, additional, Small, Erin V., additional, Cobo-Stark, Patricia, additional, Igarashi, Peter, additional, Murakami, Masao, additional, Tominaga, Junji, additional, Sato, Takahiro, additional, Asano, Tomoichiro, additional, Kurihara, Yukiko, additional, and Kurihara, Hiroki, additional

Published
2008
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41. Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ.

Author

Makita, Ryosuke, Uchijima, Yasunobu, Nishiyama, Koichi, Amano, Tomokazu, Qin Chen, Takeuchi, Takumi, Mitani, Akihisa, Nagase, Takahide, Yatomi, Yutaka, Aburatani, Hiroyuki, Nakagawa, Osamu, Small, Erin V., Cobo-Stark, Patricia, Igarashi, Peter, Murakami, Masao, Tominaga, Junji, Sato, Takahiro, Asano, Tomoichiro, Kurihara, Yukiko, and Kurihara, Hiroki

Subjects
CYSTIC kidney disease, GENE silencing, POLYCYSTIC kidney disease, PULMONARY emphysema, HYDRONEPHROSIS, LABORATORY mice
Abstract

TAZ (transcriptional coactivator with PDZ-binding motif), also called WWTR1 (WW domain containing transcription regulator 1), is a 14-3-3-binding molecule homologous to Yes-associated protein. TAZ acts as a coactivator for several transcription factors as well as a modulator of membrane-associated PDZ domain-containing proteins, but its (patho)physiological roles remain unknown. Here we show that gene inactivation of TAZ in mice resulted in pathological changes in the kidney and lung that resemble the common human diseases polycystic kidney disease and pulmonary emphysema. Taz-null/lacZ knockin mutant homozygotes demonstrated renal cyst formation as early as embryonic day 15.5 with dilatation of Bowman's capsules and proximal tubules, followed by pelvic dilatation and hydronephrosis. After birth, only one-fifth of TAZ-deficient homozygotes grew to adulthood and demonstrated multicystic kidneys with severe urinary concentrating defects and polyuria. Furthermore, adult TAZ-deficient homozygotes exhibited diffuse emphysematous changes in the lung. Thus TAZ is essential for developmental mechanisms involved in kidney and lung organogenesis, whose disturbance may lead to the pathogenesis of common human diseases. [ABSTRACT FROM AUTHOR]

Published
2008
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