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1. Isolation and Functions of Extracellular Vesicles Derived from Parasites: The Promise of a New Era in Immunotherapy, Vaccination, and Diagnosis

Author: Khosravi M, Mirsamadi ES, Mirjalali H, and Zali MR
Subjects: parasites, extracellular vesicles, immunotherapy, vaccination, diagnosis., Medicine (General), R5-920
Abstract: Mojdeh Khosravi,1 Elnaz Sadat Mirsamadi,2 Hamed Mirjalali,3 Mohammad Reza Zali4 1Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain; 2Department of Microbiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; 3Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, IranCorrespondence: Hamed MirjalaliFoodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, IranEmail hamed_mirjalali@hotmail.comAbstract: Experimental and epidemiological evidence shows that parasites, particularly helminths, play a central role in balancing the host immunity. It was demonstrated that parasites can modulate immune responses via their excretory/secretory (ES) and some specific proteins. Extracellular vesicles (EVs) are nano-scale particles that are released from eukaryotic and prokaryotic cells. EVs in parasitological studies have been mostly employed for immunotherapy of autoimmune diseases, vaccination, and diagnosis. EVs can carry virulence factors and play a central role in the development of parasites in host cells. These molecules can manipulate the immune responses through transcriptional changes. Moreover, EVs derived from helminths modulate the immune system via provoking anti-inflammatory cytokines. On the other hand, EVs from parasite protozoa can induce efficient immunity, that makes them useful for probable next-generation vaccines. In addition, it seems that EVs from parasites may provide new diagnostic approaches for parasitic infections. In the current study, we reviewed isolation methods, functions, and applications of parasite’s EVs in immunotherapy, vaccination, and diagnosis.Keywords: parasites, extracellular vesicles, immunotherapy, vaccination, diagnosis
Published: 2020

2. The first study on opportunistic intestinal microsporidiosis in IBD patients receiving immunosuppressive medications in Iran

Author: HASANI, Z., AGHDAEI, H. ASADZADEH, BALAII, H., AZIMIRAD, M., MIRSAMADI, E. S., MIRJALALI, H., and ZALI, M.R.
Published: 2017

3. Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Author: Kinyoki, D, Ross, J, Lazzar-Atwood, A, Munro, S, Schaeffer, L, Abbasalizad-Farhangi, M, Abbasi, M, Abbastabar, H, Abdelalim, A, Abdoli, A, Abdollahi, M, Abdollahpour, I, Abdulkader, R, Abebe, N, Abebo, T, Abegaz, K, Abolhassani, H, Abreu, L, Abrigo, M, Abushouk, A, Accrombessi, M, Acharya, D, Adabi, M, Adebiyi, A, Adedeji, I, Adekanmbi, V, Adeoye, A, Adetokunboh, O, Adham, D, Aduroja, P, Advani, S, Afarideh, M, Aghaali, M, Agrawal, A, Ahmad, T, Ahmadi, K, Ahmadi, S, Ahmed, M, Ahmed, R, Ajumobi, O, Akal, C, Akalu, T, Akinyemiju, T, Akombi, B, Al-Aly, Z, Alam, S, Alamene, G, Alanzi, T, Rabanal, J, Alema, N, Ali, B, Ali, M, Alijanzadeh, M, Alinia, C, Alipour, V, Alizade, H, Aljunid, S, Almasi, A, Almasi-Hashiani, A, Al-Mekhlafi, H, Al-Raddadi, R, Altirkawi, K, Alvis-Guzman, N, Alvis-Zakzuk, N, Amare, A, Amegah, A, Amini, S, Rarani, M, Amiri, F, Amit, A, Anber, N, Andrei, C, Ansari, F, Ansari-Moghaddam, A, Anteneh, Z, Antonio, C, Antriyandarti, E, Anvari, D, Anwer, R, Appiah, S, Arabloo, J, Arab-Zozani, M, Araya, E, Arefi, Z, Aremu, O, Arnlov, J, Arzani, A, Asadi-Aliabadi, M, Asadi-Pooya, A, Asgari, S, Asghari, B, Ashagre, A, Asrat, A, Ataeinia, B, Atalay, H, Atnafu, D, Atout, M, Ausloos, M, Avokpaho, E, Awasthi, A, Quintanilla, B, Ayanore, M, Aynalem, Y, Azadmehr, A, Azari, S, Azarian, G, Azene, Z, Babaee, E, Badawi, A, Badiye, A, Bahrami, M, Baig, A, Bakhtiari, A, Bakkannavar, S, Balakrishnan, S, Bali, A, Banach, M, Banik, P, Baradaran-Seyed, Z, Baraki, A, Barboza, M, Barnighausen, T, Barua, L, Basaleem, H, Basu, S, Bayati, M, Bayih, M, Baynes, H, Bedi, N, Behzadifar, M, Bekele, Y, Bennett, D, Berbada, D, Berhe, K, Berhe, A, Berman, A, Bernstein, R, Bhageerathy, R, Bhandari, D, Bharadwaj, P, Bhattacharjee, N, Bhattacharyya, K, Bijani, A, Bikbov, B, Bilano, V, Bililign, N, Sayeed, M, Birara, S, Birhane, M, Birhanu, M, Biswas, R, Bitew, Z, Bogale, K, Bohlouli, S, Bolla, S, Boloor, A, Borzi, A, Borzouei, S, Brady, O, Bragazzi, N, Braithwaite, D, Briko, N, Britton, G, Budhathoki, S, Nagaraja, S, Busse, R, Butt, Z, Cahuana-Hurtado, L, Camera, L, Campos-Nonato, I, Cano, J, Car, J, Cardenas, R, Carrero, J, Carvalho, F, Castaldelli-Maia, J, Castaneda-Orjuela, C, Castro, F, Cerin, E, Chansa, C, Charan, J, Chatterjee, P, Chattu, V, Chauhan, B, Chavshin, A, Chehrazi, M, Chichiabellu, T, Chin, K, Christopher, D, Chu, D, Cicuttini, F, Collison, M, Cork, M, Cormier, N, Cortesi, P, Costa, V, Dadi, A, Dagnew, B, Dahlawi, S, Damiani, G, Darwish, A, Daryani, A, Das, J, Gupta, R, Davila-Cervantes, C, Davis Weaver, N, Leo, D, Neve, J, Demeke, F, Demis, A, Demissie, D, Demoz, G, Denova-Gutierrez, E, Deribe, K, Desai, R, Desalegn, B, Desalew, A, Deshpande, A, Dey, S, Dharmaratne, S, Dhillon, P, Dhimal, M, Dhungana, G, Nasab, M, Diaz, D, Forooshani, Z, Dinsa, G, Dipeolu, I, Djalalinia, S, Do, H, Doku, P, Dorostkar, F, Doshmangir, L, Dubey, M, Adema, B, Dunachie, S, Duncan, B, Duraes, A, Earl, L, Leylabadlo, H, Eftekhari, A, El Sayed, I, El Sayed Zaki, M, El Tantawi, M, Elbarazi, I, Elemineh, D, El-Jaafary, S, El-Khatib, Z, Elsharkawy, A, El-Sherbiny, Y, Elyazar, I, Emamian, M, Enany, S, Endalew, D, Endalifer, M, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Esteghamati, A, Etemadi, A, Etisso, A, Fanzo, J, Farahmand, M, Faraj, A, Farashi, S, Fareed, M, Farioli, A, Faro, A, Farzadfar, F, Farzam, H, Fatima, S, Fattahi, N, Fauk, N, Fazaeli, A, Fentahun, N, Ferede, T, Fereshtehnejad, S, Fernandes, E, Fernandes, J, Feyissa, G, Filip, I, Fischer, F, Flohr, C, Foigt, N, Folayan, M, Fomenkov, A, Foroutan, M, Forster, J, Francis, J, Fukumoto, T, Gayesa, R, Geberemariyam, B, Gebrehiwot, T, Gebremariam, H, Gebremariam, K, Gebremedhin, K, Gebremeskel, G, Gebreslassie, A, Gebretsadik, G, Gedefaw, G, Geramo, Y, Gesesew, H, Geta, B, Getenet, A, Gezae, K, Ghaffarifar, F, Ghafourifard, M, Ghajar, A, Ghajarzadeh, M, Ghashghaee, A, Ghiasvand, H, Gholamian, A, Gilani, S, Gill, T, Ginawi, I, Goli, S, Gomes, N, Gopalani, S, Goudarzi, H, Goulart, A, Govindakarnavar, A, Grada, A, Grivna, M, Guimaraes, R, Guled, R, Guo, Y, Hafezi-Nejad, N, Haile, M, Haj-Mirzaian, A, Hall, B, Halvaei, I, Hamadeh, R, Hamidi, Y, Handiso, D, Hankey, G, Haririan, H, Hariyani, N, Hasaballah, A, Hasan, M, Hasankhani, M, Hasanpoor, E, Hasanzadeh, A, Hashemian, M, Hassanipour, S, Hassen, H, Havmoeller, R, Hawkes, C, Hayat, K, Hayelom, D, Heidari, B, Heidari-Soureshjani, R, Hendrie, D, Henok, A, Henry, N, Herrero, M, Herteliu, C, Heydarpour, F, de Hidru, H, Hoang, C, Hoek, H, Hole, M, Holla, R, Hollerich, G, Rad, E, Hong, S, Hoogar, P, Horino, M, Hossain, N, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Housseh, M, Hsairi, M, Hu, G, Huda, T, Humayun, A, Hwang, B, Ibitoye, S, Ilesanmi, O, Ilic, M, Imani-Nasab, M, Inbaraj, L, Iqbal, U, Irvani, S, Islam, S, Iwu, C, Izadi, N, Jaafari, J, Jaca, A, Jadidi-Niaragh, F, Balalami, N, Jafarinia, M, Jahani, M, Jakovljevic, M, Jalali, A, Jalilian, F, Jayatilleke, A, Jeemon, P, Jehan, F, Jenabi, E, Jha, R, Jha, V, Ji, J, Jia, P, John, O, John-Akinola, Y, Johnson, K, Jonas, J, Joseph, N, Joukar, F, Jozwiak, J, Jungari, S, Jurisson, M, Kabir, A, Kabir, Z, Kahsay, A, Kahssay, M, Kalani, H, Kalankesh, L, Kalhor, R, Kamiab, Z, Kanchan, T, Kapil, U, Kapoor, N, Karami, M, Matin, B, Karch, A, Karim, M, Karki, S, Kasaeian, A, Kasahun, G, Kasaye, H, Kassa, T, Kassaye, H, Kassebaum, N, Karyani, A, Kengne, A, Ketema, D, Khader, Y, Khafaie, M, Khaksarian, M, Khalid, N, Khalil, I, Khalilov, R, Khan, A, Khan, E, Khan, M, Khatab, K, Khater, A, Khater, M, Khatib, M, Khayamzadeh, M, Khazaei-Pool, M, Khazaei, M, Khazaei, S, Khodayari, M, Khosravi, M, Khundkar, R, Kiadaliri, A, Kianipour, N, Kiirithio, D, Kim, Y, Kimokoti, R, Kisa, A, Kisa, S, Kolola, T, Komaki, H, Kondlahalli, S, Koolivand, A, Koul, P, Koyanagi, A, Kraemer, M, Krishan, K, Krohn, K, Kugbey, N, Kumar, M, Kumar, P, Kumar, V, Kurmi, O, Kuti, O, Vecchia, C, Lacey, B, Lad, D, Lal, A, Lal, D, Lami, F, Lamichhane, P, Lang, J, Lansingh, V, Lasrado, S, Lebedev, G, Lee, P, Lee, S, Leili, M, Letourneau, I, Lewycka, S, Li, S, Lim, L, Linn, S, Liu, S, Lodha, R, Longbottom, J, Lopez, J, Lorkowski, S, Macarayan, E, Madadin, M, El Razek, H, El Razek, M, Maghavani, D, Mahasha, P, Mahotra, N, Maled, V, Maleki, A, Maleki, S, Malta, D, Manafi, A, Manafi, F, Manafi, N, Manohar, N, Mansour-Ghanaei, F, Mansouri, B, Mansournia, M, Mapoma, C, Marami, D, Marczak, L, Arnedo, C, Martins-Melo, F, Masaka, A, Massenburg, B, Maulik, P, Mayala, B, Mazidi, M, Mehndiratta, M, Mehri, F, Mehta, K, Meitei, W, Mekonnen, F, Mekonnen, T, Meles, G, Meles, H, Melese, A, Mendoza, W, Menezes, R, Mengesha, M, Mensah, G, Meretoja, T, Miazgowski, T, Kostova, N, Miller, T, Mills, E, Mini, G, Mir, S, Miri, M, Mirjalali, H, Mirrakhimov, E, Mirzaei, H, Mirzaei, M, Mirzaei, R, Mirzaei-Alavijeh, M, Mithra, P, Moazen, B, Mohamadi, E, Mohamadi-Bolbanabad, A, Mohammad, K, Mohammad, Y, Mohammad, D, Darwesh, A, Mezerji, N, Mohammadian-Hafshejani, A, Mohammadnia-Afrouzi, M, Mohammadoo-Khorasani, M, Mohammadpourhodki, R, Mohammed, S, Mohammed, J, Mohammed, A, Mohebi, F, Mokari, A, Mokdad, A, Montanez, J, Montero-Zamora, P, Moodley, Y, Moossavi, M, Moradi, G, Moradi, M, Moradi, Y, Moradi-Joo, M, Moradi-Lakeh, M, Moradpour, F, Moradzadeh, R, Moraga, P, Morrison, S, Mosapour, A, Mosser, J, Mouodi, S, Khaneghah, A, Mozaffarian, D, Mueller, U, Murray, C, Murthy, G, Musa, K, Mustafa, G, Muthupandian, S, Nabavizadeh, B, Naderi, M, Nadkarni, G, Nagarajan, A, Naghavi, M, Naheed, A, Naik, G, Najafi, F, Nansseu, J, Narayan, K, Nascimento, B, Nayak, V, Nazari, J, Ndwandwe, D, Negoi, I, Negoi, R, Ngunjiri, J, Nguyen, C, Nguyen, H, Nigatu, D, Nigatu, Y, Nikbakhsh, R, Ningrum, D, Nnaji, C, Nong, V, Noubiap, J, Nowak, C, Oancea, B, Ofori-Asenso, R, Oghenetega, O, Oh, I, Oladimeji, O, Oladnabi, M, Olagunju, A, Olagunju, T, Olusanya, B, Olusanya, J, Oluwasanu, M, Omer, M, Onwujekwe, O, Asante, K, Oren, E, Orisakwe, O, Ortiz, A, Osarenotor, O, Osgood-Zimmerman, A, Owolabi, M, P. A, M, Padubidri, J, Pakshir, K, Pana, A, Panda-Jonas, S, Parsian, H, Pashaei, T, Pasupula, D, Patel, S, Pathak, A, Pathak, M, Pati, S, Patle, A, Patton, G, Paulos, K, Toroudi, H, Pepito, V, Perico, N, Petri, W, Pickering, B, Pigott, D, Pirestani, M, Piroozi, B, Pirsaheb, M, Pokhrel, K, Postma, M, Pourjafar, H, Pourmalek, F, Kalhori, R, Pourshams, A, Poustchi, H, Prada, S, Preotescu, L, Pribadi, D, Syed, Z, Rabiee, M, Rabiee, N, Radfar, A, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Rahman, M, Rahman, S, Rai, R, Rajabpour-Sanati, A, Rajati, F, Ramezanzadeh, K, Rana, S, Ranabhat, C, Rao, S, Rasella, D, Rashedi, V, Rastogi, P, Rathi, P, Rawaf, S, Rawaf, D, Rawal, L, Ray, S, Remuzzi, G, Renjith, V, Renzaho, A, Resnikoff, S, Rezaei, N, Rezaeian, S, Rezai, M, Rezapour, A, Riahi, S, Ribeiro, A, Rickard, J, Rodriguez, A, Roever, L, Roro, E, Roshandel, G, Rostami, A, Rubagotti, E, Saad, A, Saadatagah, S, Sabde, Y, Sabour, S, Sadeghi, E, Sadeghi, M, Safari, S, Safari, Y, Safarpour, H, Sagar, R, Sahebkar, A, Sahraian, M, Sajadi, S, Salahshoor, M, Salam, N, Salehi, F, Zahabi, S, Salem, H, Salem, M, Salimi, Y, Salimzadeh, H, Kafil, H, Sambala, E, Samy, A, Santos, I, Jose, B, Saraswathy, S, Sarker, A, Sartorius, B, Sarveazad, A, Sathian, B, Satpathy, M, Saxena, S, Sayyah, M, Sbarra, A, Schipp, M, Schmidt, M, Schutte, A, Schwebel, D, Senbeta, A, Senthilkumaran, S, Seyedmousavi, S, Shaahmadi, F, Shafaat, O, Shahabi, S, Shaikh, M, Shalash, A, Shams-Beyranvand, M, Shamshirian, A, Shamsizadeh, M, Shannawaz, M, Sharafi, K, Sharif, M, Sharma, R, Shehata, H, Sheikhtaheri, A, Shibuya, K, Shiferaw, W, Shigematsu, M, Shin, J, Shiri, R, Shirkoohi, R, Shiue, I, Shuval, K, Siabani, S, Siddiqi, T, Sigfusdottir, I, Silva, D, Simonetti, B, Singh, A, Singh, P, Singh, V, Singh, J, Sinha, D, Sintayehu, Y, Sisay, M, Soheili, A, Soleymani, B, Soltani, F, Soltani, S, Soriano, J, Sorrie, M, Soshnikov, S, Soyiri, I, Spotin, A, Sreeramareddy, C, Srivastava, R, Starodubova, A, Sudaryanto, A, Sufiyan, M, Suleria, H, Sulo, G, Sunguya, B, Sykes, B, Tabares-Seisdedos, R, Tabuchi, T, Tadesse, B, Taherkhani, A, Tamirat, K, Tassew, S, Taveira, N, Teklehaimanot, B, Tekulu, G, Temsah, M, Terkawi, A, Tessema, Z, Thomas, N, Titova, M, Tlaye, K, Tohidinik, H, Tonelli, M, Tovani-Palone, M, Traini, E, Tran, K, Tripathi, M, Uddin, R, Ullah, I, Unnikrishnan, B, Upadhyay, E, Useh, U, Usman, M, Uthman, O, Vacante, M, Vaezghasemi, M, Valdez, P, Vanderheide, J, Varavikova, E, Varughese, S, Vasankari, T, Vasseghian, Y, Veisani, Y, Venkatesh, S, Venketasubramanian, N, Verma, M, Vidale, S, Violante, F, Vlassov, V, Vollmer, S, Vukovic, R, Waheed, Y, Wang, H, Wang, Y, Weldesamuel, G, Werdecker, A, Wiangkham, T, Wiens, K, Wijeratne, T, Wolde, H, Wondafrash, D, Wonde, T, Wondmieneh, A, Wu, A, Xu, G, Yadegar, A, Yadollahpour, A, Jabbari, S, Yamada, T, Yano, Y, Yaya, S, Yazdi-Feyzabadi, V, Yeshaneh, A, Yeshaw, Y, Yeshitila, Y, Yilma, M, Yip, P, Yonemoto, N, Yoon, S, Youm, Y, Younis, M, Yousefi, Z, Yousof, H, Yu, C, Yusefzadeh, H, Moghadam, T, Zaki, L, Zaman, S, Zamani, M, Zamanian, M, Zandian, H, Zarafshan, H, Zepro, N, Zerfu, T, Zewale, T, Zhang, Y, Zhang, Z, Zhao, X, Zodpey, S, Zomorodian, K, Zotor, F, Afshin, A, Hay, S, Kinyoki D. K., Ross J. M., Lazzar-Atwood A., Munro S. B., Schaeffer L. E., Abbasalizad-Farhangi M., Abbasi M., Abbastabar H., Abdelalim A., Abdoli A., Abdollahi M., Abdollahpour I., Abdulkader R. S., Abebe N. D., Abebo T. A., Abegaz K. H., Abolhassani H., Abreu L. G., Abrigo M. R. M., Abushouk A. I., Accrombessi M. M. K., Acharya D., Adabi M., Adebiyi A. O., Adedeji I. A., Adekanmbi V., Adeoye A. M., Adetokunboh O. O., Adham D., Aduroja P. E., Advani S. M., Afarideh M., Aghaali M., Agrawal A., Ahmad T., Ahmadi K., Ahmadi S., Ahmed M. B., Ahmed R., Ajumobi O., Akal C. G., Akalu T. Y., Akinyemiju T., Akombi B., Al-Aly Z., Alam S., Alamene G. M., Alanzi T. M., Rabanal J. E. A., Alema N. M., Ali B. A., Ali M., Alijanzadeh M., Alinia C., Alipour V., Alizade H., Aljunid S. M., Almasi A., Almasi-Hashiani A., Al-Mekhlafi H. M., Al-Raddadi R. M., Altirkawi K., Alvis-Guzman N., Alvis-Zakzuk N. J., Amare A. T., Amegah A. K., Amini S., Rarani M. A., Amiri F., Amit A. M. L., Anber N. H., Andrei C. L., Ansari F., Ansari-Moghaddam A., Anteneh Z. A., Antonio C. A. T., Antriyandarti E., Anvari D., Anwer R., Appiah S. C. Y., Arabloo J., Arab-Zozani M., Araya E. M., Arefi Z., Aremu O., Arnlov J., Arzani A., Asadi-Aliabadi M., Asadi-Pooya A. A., Asgari S., Asghari B., Ashagre A. F., Asrat A. A., Ataeinia B., Atalay H. T., Atnafu D. D., Atout M. M. W., Ausloos M., Avokpaho E. F. G. A., Awasthi A., Quintanilla B. P. A., Ayanore M. A., Aynalem Y. A. A., Azadmehr A., Azari S., Azarian G., Azene Z. N., Babaee E., Badawi A., Badiye A. D., Bahrami M. A., Baig A. A. A., Bakhtiari A., Bakkannavar S. M., Balakrishnan S., Bali A. G., Banach M., Banik P. C., Baradaran-Seyed Z., Baraki A. G., Barboza M. A., Barnighausen T. W., Barua L., Basaleem H., Basu S., Bayati M., Bayih M. T., Baynes H. W., Bedi N., Behzadifar M., Bekele Y. A., Bennett D. A., Berbada D. A., Berhe K., Berhe A. K., Berman A. E., Bernstein R. S., Bhageerathy R., Bhandari D., Bharadwaj P., Bhattacharjee N. V., Bhattacharyya K., Bijani A., Bikbov B., Bilano V., Bililign N., Sayeed M. S. B., Birara S., Birhane M. B. B., Birhanu M., Biswas R. K., Bitew Z. W., Bogale K. A., Bohlouli S., Bolla S. R., Boloor A., Borzi A. M., Borzouei S., Brady O. J., Bragazzi N. L., Braithwaite D., Briko N. I., Britton G., Budhathoki S. S., Nagaraja S. B., Busse R., Butt Z. A., Cahuana-Hurtado L., Camera L. A., Campos-Nonato I. R., Cano J., Car J., Cardenas R., Carrero J. J., Carvalho F., Castaldelli-Maia J. M., Castaneda-Orjuela C. A., Castro F., Cerin E., Chansa C., Charan J., Chatterjee P., Chattu V. K., Chauhan B. G., Chavshin A. R., Chehrazi M., Chichiabellu T. Y., Chin K. L., Christopher D. J., Chu D. -T., Cicuttini F. M., Collison M. L., Cork M. A., Cormier N., Cortesi P. A., Costa V. M., Dadi A. F. F., Dagnew B., Dahlawi S. M. A., Damiani G., Darwish A. H., Daryani A., Das J. K., Gupta R. D., Davila-Cervantes C., Davis Weaver N., Leo D. D., Neve J. -W. D., Demeke F. M., Demis A. B., Demissie D. B., Demoz G. T., Denova-Gutierrez E., Deribe K., Desai R., Desalegn B. B., Desalew A., Deshpande A., Dey S., Dharmaratne S. D., Dhillon P., Dhimal M., Dhungana G. P., Nasab M. D., Diaz D., Forooshani Z. S. D., Dinsa G. D., Dipeolu I. O., Djalalinia S., Do H. T., Do H. P., Doku P. N., Dorostkar F., Doshmangir L., Dubey M., Adema B. D., Dunachie S. J., Duncan B. B., Duraes A. R., Earl L., Leylabadlo H. E., Eftekhari A., El Sayed I., El Sayed Zaki M., El Tantawi M., Elbarazi I., Elemineh D. A., El-Jaafary S. I., El-Khatib Z., Elsharkawy A., El-Sherbiny Y. M., Elyazar I. R. F., Emamian M. H., Enany S., Endalew D. A., Endalifer M. L., Eskandari K., Eskandarieh S., Esmaeilnejad S., Esteghamati A., Etemadi A., Etisso A. E., Fanzo J., Farahmand M., Faraj A., Farashi S., Fareed M., Farioli A., Faro A., Farzadfar F., Farzam H., Fatima S. S., Fattahi N., Fauk N. K., Fazaeli A. A., Fentahun N., Ferede T. Y., Fereshtehnejad S. -M., Fernandes E., Fernandes J. C., Feyissa G. 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L., Rawal L., Ray S. E., Remuzzi G., Renjith V., Renzaho A. M. N., Resnikoff S., Rezaei N., Rezaeian S., Rezai M. S., Rezapour A., Riahi S. M., Ribeiro A. I., Rickard J., Rodriguez A., Roever L., Roro E. M., Roshandel G., Rostami A., Rubagotti E., Saad A. M., Saadatagah S., Sabde Y. D., Sabour S., Sadeghi E., Sadeghi M., Safari S., Safari Y., Safarpour H., Sagar R., Sahebkar A., Sahraian M. A., Sajadi S. M., Salahshoor M. R., Salam N., Salehi F., Zahabi S. S., Salem H., Salem M. R. R., Salimi Y., Salimzadeh H., Kafil H. S., Sambala E. Z., Samy A. M., Santos I. S., Jose B. P. S., Saraswathy S. Y. I., Sarker A. R., Sartorius B., Sarveazad A., Sathian B., Satpathy M., Saxena S., Sayyah M., Sbarra A. N., Schipp M. F., Schmidt M. I., Schutte A. E., Schwebel D. C., Senbeta A. M., Senthilkumaran S., Seyedmousavi S., Shaahmadi F., Shafaat O., Shahabi S., Shaikh M. A., Shalash A. S., Shams-Beyranvand M., Shamshirian A., Shamsizadeh M., Shannawaz M., Sharafi K., Sharif M., Sharma R., Shehata H. S., Sheikhtaheri A., Shibuya K., Shiferaw W. S., Shigematsu M., Shin J. I., Shiri R., Shirkoohi R., Shiue I., Shuval K., Siabani S., Siddiqi T. J., Sigfusdottir I. D., Silva D. A. S., Simonetti B., Singh A., Singh P., Singh V., Singh J. A., Singh P. K., Sinha D. N., Sintayehu Y., Sisay M. M. M., Soheili A., Soleymani B., Soltani F., Soltani S., Soriano J. B., Sorrie M. B., Soshnikov S., Soyiri I. N., Spotin A., Sreeramareddy C. T., Srivastava R. K. K., Starodubova A., Sudaryanto A., Sufiyan M. B., Suleria H. A. R., Sulo G., Sunguya B. F., Sykes B. L., Tabares-Seisdedos R., Tabuchi T., Tadesse B. T., Taherkhani A., Tamirat K. S., Tassew S. G., Taveira N., Teklehaimanot B. F., Tekulu G. H., Temsah M. -H., Terkawi A. S., Tessema Z. T., Thomas N., Titova M. V., Tlaye K. G., Tohidinik H. R., Tonelli M., Tovani-Palone M. R., Traini E., Tran K. B., Tripathi M., Uddin R., Ullah I., Unnikrishnan B., Upadhyay E., Useh U., Usman M. S., Uthman O. A., Vacante M., Vaezghasemi M., Valdez P. R., VanderHeide J., Varavikova E., Varughese S., Vasankari T. J., Vasseghian Y., Veisani Y., Venkatesh S., Venketasubramanian N., Verma M., Vidale S., Violante F. S., Vlassov V., Vollmer S., Vukovic R., Waheed Y., Wang H., Wang Y., Wang Y. -P., Weldesamuel G. T., Werdecker A., Wiangkham T., Wiens K. E., Wijeratne T., Wolde H. F., Wondafrash D. Z., Wonde T. E., Wondmieneh A. B., Wu A. -M., Xu G., Yadegar A., Yadollahpour A., Jabbari S. H. Y., Yamada T., Yano Y., Yaya S., Yazdi-Feyzabadi V., Yeshaneh A., Yeshaw Y., Yeshitila Y. G., Yilma M. T., Yip P., Yonemoto N., Yoon S. -J., Youm Y., Younis M. Z., Yousefi Z., Yousof H. -A. S. A., Yu C., Yusefzadeh H., Moghadam T. Z., Zaki L., Zaman S. B., Zamani M., Zamanian M., Zandian H., Zarafshan H., Zepro N. B., Zerfu T. A., Zewale T. A., Zhang Y., Zhang Z. -J., Zhao X. -J., Zodpey S., Zomorodian K., Zotor F. B., Afshin A., and Hay S. I.
Abstract: A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic.
Published: 2020

4. Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

Author: Burstein, R., Henry, N. J., Collison, M. L., Marczak, L. B., Sligar, A., Watson, S., Marquez, N., Abbasalizad-Farhangi, M., Abbasi, M., Abd-Allah, F., Abdoli, A., Abdollahi, M., Abdollahpour, I., Abdulkader, R. S., Abrigo, M. R. M., Acharya, D., Adebayo, O. M., Adekanmbi, V., Adham, D., Afshari, M., Aghaali, M., Ahmadi, K., Ahmadi, M., Ahmadpour, E., Ahmed, R., Akal, C. G., Akinyemi, J. O., Alahdab, F., Alam, N., Alamene, G. M., Alene, K. A., Alijanzadeh, M., Alinia, C., Alipour, V., Aljunid, S. M., Almalki, M. J., Al-Mekhlafi, H. M., Altirkawi, K., Alvis-Guzman, N., Amegah, A. K., Amini, S., Amit, A. M. L., Anbari, Z., Androudi, S., Anjomshoa, M., Ansari, F., Antonio, C. A. T., Arabloo, J., Arefi, Z., Aremu, O., Armoon, B., Arora, A., Artaman, A., Asadi, A., Asadi-Aliabadi, M., Ashraf-Ganjouei, A., Assadi, R., Ataeinia, B., Atre, S. R., Quintanilla, B. P. A., Ayanore, M. A., Azari, S., Babaee, E., Babazadeh, A., Badawi, A., Bagheri, S., Bagherzadeh, M., Baheiraei, N., Balouchi, A., Barac, A., Bassat, Q., Baune, B. T., Bayati, M., Bedi, N., Beghi, E., Behzadifar, M., Belay, Y. B., Bell, B., Bell, M. L., Berbada, D. A., Bernstein, R. S., Bhattacharjee, N. V., Bhattarai, S., Bhutta, Z. A., Bijani, A., Bohlouli, S., Breitborde, N. J. K., Britton, G., Browne, A. J., Nagaraja, S. B., Busse, R., Butt, Z. A., Car, J., CÃ¡rdenas, R., CastaÃ±eda-Orjuela, C. A., Cerin, E., Chanie, W. F., Chatterjee, P., Chu, D. -T, Cooper, C., Costa, V. M., Dalal, Koustuv, Dandona, L., Dandona, R., Daoud, F., Daryani, A., Das Gupta, R., Davis, I., Davis Weaver, N., Davitoiu, D. V., De Neve, J. -W, Demeke, F. M., Demoz, G. T., Deribe, K., Desai, R., Deshpande, A., Desyibelew, H. D., Dey, S., Dharmaratne, S. D., Dhimal, M., Diaz, D., Doshmangir, L., Duraes, A. R., Dwyer-Lindgren, L., Earl, L., Ebrahimi, R., Ebrahimpour, S., Effiong, A., Eftekhari, A., Ehsani-Chimeh, E., El Sayed, I., El Sayed Zaki, M., El Tantawi, M., El-Khatib, Z., Emamian, M. H., Enany, S., Eskandarieh, S., Eyawo, O., Ezalarab, M., Faramarzi, M., Fareed, M., Faridnia, R., Faro, A., Fazaeli, A. A., Fazlzadeh, M., Fentahun, N., Fereshtehnejad, S. -M, Fernandes, J. C., Filip, I., Fischer, F., Foigt, N. A., Foroutan, M., Francis, J. M., Fukumoto, T., Fullman, N., Gallus, S., Gebre, D. G., Gebrehiwot, T. T., Gebremeskel, G. G., Gessner, B. D., Geta, B., Gething, P. W., Ghadimi, R., Ghadiri, K., Ghajarzadeh, M., Ghashghaee, A., Gill, P. S., Gill, T. K., Golding, N., Gomes, N. G. M., Gona, P. N., Gopalani, S. V., Gorini, G., Goulart, B. N. G., Graetz, N., Greaves, F., Green, M. S., Guo, Y., Haj-Mirzaian, A., Hall, B. J., Hamidi, S., Haririan, H., Haro, J. M., Hasankhani, M., Hasanpoor, E., Hasanzadeh, A., Hassankhani, H., Hassen, H. Y., Hegazy, M. I., Hendrie, D., Heydarpour, F., Hird, T. R., Hoang, C. L., Hollerich, G., Rad, E. H., Hoseini-Ghahfarokhi, M., Hossain, N., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Hsairi, M., Ilesanmi, O. S., Imani-Nasab, M. H., Iqbal, U., Irvani, S. S. N., Islam, N., Islam, S. M. S., JÃŒrisson, M., Balalami, N. J., Jalali, A., Javidnia, J., Jayatilleke, A. U., Jenabi, E., Ji, J. S., Jobanputra, Y. B., Johnson, K., Jonas, J. B., Shushtari, Z. J., Jozwiak, J. J., Kabir, A., Kahsay, A., Kalani, H., Kalhor, R., Karami, M., Karki, S., Kasaeian, A., Kassebaum, N. J., Keiyoro, P. N., Kemp, G. R., Khabiri, R., Khader, Y. S., Khafaie, M. A., Khan, E. A., Khan, J., Khan, M. S., Khang, Y. -H, Khatab, K., Khater, A., Khater, M. M., Khatony, A., Khazaei, M., Khazaei, S., Khazaei-Pool, M., Khubchandani, J., Kianipour, N., Kim, Y. J., Kimokoti, R. W., Kinyoki, D. K., Kisa, A., Kisa, S., Kolola, T., Kosen, S., Koul, P. A., Koyanagi, A., Kraemer, M. U. G., Krishan, K., Krohn, K. J., Kugbey, N., Kumar, G. A., Kumar, M., Kumar, P., Kuupiel, D., Lacey, B., Lad, S. D., Lami, F. H., Larsson, A. O., Lee, P. H., Leili, M., Levine, A. J., Li, S., Lim, L. -L, Listl, S., Longbottom, J., Lopez, J. C. F., Lorkowski, S., Magdeldin, S., Abd El Razek, H. M., Abd El Razek, M. M., Majeed, A., Maleki, A., Malekzadeh, R., Malta, D. C., Mamun, A. A., Manafi, N., Manda, A. -L, Mansourian, M., Martins-Melo, F. R., Masaka, A., Massenburg, B. B., Maulik, P. K., Mayala, B. K., Mazidi, M., McKee, M., Mehrotra, R., Mehta, K. M., Meles, G. G., Mendoza, W., Menezes, R. G., Meretoja, A., Meretoja, T. J., Mestrovic, T., Miller, T. R., Miller-Petrie, M. K., Mills, E. J., Milne, G. J., Mini, G. K., Mir, S. M., Mirjalali, H., Mirrakhimov, E. M., Mohamadi, E., Mohammad, D. K., Darwesh, A. M., Mezerji, N. M. G., Mohammed, A. S., Mohammed, S., Mokdad, A. H., Molokhia, M., Monasta, L., Moodley, Y., Moosazadeh, M., Moradi, G., Moradi, M., Moradi, Y., Moradi-Lakeh, M., Moradinazar, M., Moraga, P., Morawska, L., Mosapour, A., Mousavi, S. M., Mueller, U. O., Muluneh, A. G., Mustafa, G., Nabavizadeh, B., Naderi, M., Nagarajan, A. J., Nahvijou, A., Najafi, F., Nangia, V., Ndwandwe, D. E., Neamati, N., Negoi, I., Negoi, R. I., Ngunjiri, J. W., Thi Nguyen, H. L., Nguyen, L. H., Nguyen, S. H., Nielsen, K. R., Ningrum, D. N. A., Nirayo, Y. L., Nixon, M. R., Nnaji, C. A., Nojomi, M., Noroozi, M., Nosratnejad, S., Noubiap, J. J., Motlagh, S. N., Ofori-Asenso, R., Ogbo, F. A., Oladimeji, K. E., Olagunju, A. T., Olfatifar, M., Olum, S., Olusanya, B. O., Oluwasanu, M. M., Onwujekwe, O. E., Oren, E., Ortega-Altamirano, D. D. V., Ortiz, A., Osarenotor, O., Osei, F. B., Osgood-Zimmerman, A. E., Otstavnov, S. S., Owolabi, M. O., Mahesh, P. A., Pagheh, A. S., Pakhale, S., Panda-Jonas, S., Pandey, A., Park, E. -K, Parsian, H., Pashaei, T., Patel, S. K., Pepito, V. C. F., Pereira, A., Perkins, S., Pickering, B. V., Pilgrim, T., Pirestani, M., Piroozi, B., Pirsaheb, M., Plana-Ripoll, O., Pourjafar, H., Puri, P., Qorbani, M., Quintana, H., Rabiee, M., Rabiee, N., Radfar, A., Rafiei, A., Rahim, F., Rahimi, Z., Rahimi-Movaghar, V., Rahimzadeh, S., Rajati, F., Raju, S. B., Ramezankhani, A., Ranabhat, C. L., Rasella, D., Rashedi, V., Rawal, L., Reiner Jr, R. C., Renzaho, A. M. N., Rezaei, S., Rezapour, A., Riahi, S. M., Ribeiro, A. I., Roever, L., Roro, E. M., Roser, M., Roshandel, G., Roshani, D., Rostami, A., Rubagotti, E., Rubino, S., Sabour, S., Sadat, N., Sadeghi, E., Saeedi, R., Safari, Y., Safari-Faramani, R., Safdarian, M., Sahebkar, A., Salahshoor, M. R., Salam, N., Salamati, P., Salehi, F., Zahabi, S. S., Salimi, Y., Salimzadeh, H., Salomon, J. A., Sambala, E. Z., Samy, A. M., Santric Milicevic, M. M., Jose, B. P. S., Saraswathy, S. Y. I., Sarmiento-SuÃ¡rez, R., Sartorius, B., Sathian, B., Saxena, S., Sbarra, A. N., Schaeffer, L. E., Schwebel, D. C., Sepanlou, S. G., Seyedmousavi, S., Shaahmadi, F., Shaikh, M. A., Shams-Beyranvand, M., Shamshirian, A., Shamsizadeh, M., Sharafi, K., Sharif, M., Sharif-Alhoseini, M., Sharifi, H., Sharma, J., Sharma, R., Sheikh, A., Shields, C., Shigematsu, M., Shiri, R., Shiue, I., Shuval, K., Siddiqi, T. J., Silva, J. P., Singh, J. A., Sinha, D. N., Sisay, M. M., Sisay, S., Sliwa, K., Smith, D. L., Somayaji, R., Soofi, M., Soriano, J. B., Sreeramareddy, C. T., Sudaryanto, A., Sufiyan, M. B., Sykes, B. L., Sylaja, P. N., TabarÃ©s-Seisdedos, R., Tabb, K. M., Tabuchi, T., Taveira, N., Temsah, M. -H, Terkawi, A. S., Tessema, Z. T., Thankappan, K. R., Thirunavukkarasu, S., To, Q. G., Tovani-Palone, M. R., Tran, B. X., Tran, K. B., Ullah, I., Usman, M. S., Uthman, O. A., Vahedian-Azimi, A., Valdez, P. R., van Boven, J. F. M., Vasankari, T. J., Vasseghian, Y., Veisani, Y., Venketasubramanian, N., Violante, F. S., Vladimirov, S. K., Vlassov, V., Vos, T., Vu, G. T., Vujcic, I. S., Waheed, Y., Wakefield, J., Wang, H., Wang, Y., Wang, Y. -P, Ward, J. L., Weintraub, R. G., Weldegwergs, K. G., Weldesamuel, G. T., Westerman, R., Wiysonge, C. S., Wondafrash, D. Z., Woyczynski, L., Wu, A. -M, Xu, G., Yadegar, A., Yamada, T., Yazdi-Feyzabadi, V., Yilgwan, C. S., Yip, P., Yonemoto, N., Lebni, J. Y., Younis, M. Z., Yousefifard, M., Yousof, H. -AS. A., Yu, C., Yusefzadeh, H., Zabeh, E., Moghadam, T. Z., Bin Zaman, S., Zamani, M., Zandian, H., Zangeneh, A., Zerfu, T. A., Zhang, Y., Ziapour, A., Zodpey, S., Murray, C. J. L., Hay, S. I., Burstein, R., Henry, N. J., Collison, M. L., Marczak, L. B., Sligar, A., Watson, S., Marquez, N., Abbasalizad-Farhangi, M., Abbasi, M., Abd-Allah, F., Abdoli, A., Abdollahi, M., Abdollahpour, I., Abdulkader, R. S., Abrigo, M. R. M., Acharya, D., Adebayo, O. M., Adekanmbi, V., Adham, D., Afshari, M., Aghaali, M., Ahmadi, K., Ahmadi, M., Ahmadpour, E., Ahmed, R., Akal, C. G., Akinyemi, J. O., Alahdab, F., Alam, N., Alamene, G. M., Alene, K. A., Alijanzadeh, M., Alinia, C., Alipour, V., Aljunid, S. M., Almalki, M. J., Al-Mekhlafi, H. M., Altirkawi, K., Alvis-Guzman, N., Amegah, A. K., Amini, S., Amit, A. M. L., Anbari, Z., Androudi, S., Anjomshoa, M., Ansari, F., Antonio, C. A. T., Arabloo, J., Arefi, Z., Aremu, O., Armoon, B., Arora, A., Artaman, A., Asadi, A., Asadi-Aliabadi, M., Ashraf-Ganjouei, A., Assadi, R., Ataeinia, B., Atre, S. R., Quintanilla, B. P. A., Ayanore, M. A., Azari, S., Babaee, E., Babazadeh, A., Badawi, A., Bagheri, S., Bagherzadeh, M., Baheiraei, N., Balouchi, A., Barac, A., Bassat, Q., Baune, B. T., Bayati, M., Bedi, N., Beghi, E., Behzadifar, M., Belay, Y. B., Bell, B., Bell, M. L., Berbada, D. A., Bernstein, R. S., Bhattacharjee, N. V., Bhattarai, S., Bhutta, Z. A., Bijani, A., Bohlouli, S., Breitborde, N. J. K., Britton, G., Browne, A. J., Nagaraja, S. B., Busse, R., Butt, Z. A., Car, J., CÃ¡rdenas, R., CastaÃ±eda-Orjuela, C. A., Cerin, E., Chanie, W. F., Chatterjee, P., Chu, D. -T, Cooper, C., Costa, V. M., Dalal, Koustuv, Dandona, L., Dandona, R., Daoud, F., Daryani, A., Das Gupta, R., Davis, I., Davis Weaver, N., Davitoiu, D. V., De Neve, J. -W, Demeke, F. M., Demoz, G. T., Deribe, K., Desai, R., Deshpande, A., Desyibelew, H. D., Dey, S., Dharmaratne, S. D., Dhimal, M., Diaz, D., Doshmangir, L., Duraes, A. R., Dwyer-Lindgren, L., Earl, L., Ebrahimi, R., Ebrahimpour, S., Effiong, A., Eftekhari, A., Ehsani-Chimeh, E., El Sayed, I., El Sayed Zaki, M., El Tantawi, M., El-Khatib, Z., Emamian, M. H., Enany, S., Eskandarieh, S., Eyawo, O., Ezalarab, M., Faramarzi, M., Fareed, M., Faridnia, R., Faro, A., Fazaeli, A. A., Fazlzadeh, M., Fentahun, N., Fereshtehnejad, S. -M, Fernandes, J. C., Filip, I., Fischer, F., Foigt, N. A., Foroutan, M., Francis, J. M., Fukumoto, T., Fullman, N., Gallus, S., Gebre, D. G., Gebrehiwot, T. T., Gebremeskel, G. G., Gessner, B. D., Geta, B., Gething, P. W., Ghadimi, R., Ghadiri, K., Ghajarzadeh, M., Ghashghaee, A., Gill, P. S., Gill, T. K., Golding, N., Gomes, N. G. M., Gona, P. N., Gopalani, S. V., Gorini, G., Goulart, B. N. G., Graetz, N., Greaves, F., Green, M. S., Guo, Y., Haj-Mirzaian, A., Hall, B. J., Hamidi, S., Haririan, H., Haro, J. M., Hasankhani, M., Hasanpoor, E., Hasanzadeh, A., Hassankhani, H., Hassen, H. Y., Hegazy, M. I., Hendrie, D., Heydarpour, F., Hird, T. R., Hoang, C. L., Hollerich, G., Rad, E. H., Hoseini-Ghahfarokhi, M., Hossain, N., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Hsairi, M., Ilesanmi, O. S., Imani-Nasab, M. H., Iqbal, U., Irvani, S. S. N., Islam, N., Islam, S. M. S., JÃŒrisson, M., Balalami, N. J., Jalali, A., Javidnia, J., Jayatilleke, A. U., Jenabi, E., Ji, J. S., Jobanputra, Y. B., Johnson, K., Jonas, J. B., Shushtari, Z. J., Jozwiak, J. J., Kabir, A., Kahsay, A., Kalani, H., Kalhor, R., Karami, M., Karki, S., Kasaeian, A., Kassebaum, N. J., Keiyoro, P. N., Kemp, G. R., Khabiri, R., Khader, Y. S., Khafaie, M. A., Khan, E. A., Khan, J., Khan, M. S., Khang, Y. -H, Khatab, K., Khater, A., Khater, M. M., Khatony, A., Khazaei, M., Khazaei, S., Khazaei-Pool, M., Khubchandani, J., Kianipour, N., Kim, Y. J., Kimokoti, R. W., Kinyoki, D. K., Kisa, A., Kisa, S., Kolola, T., Kosen, S., Koul, P. A., Koyanagi, A., Kraemer, M. U. G., Krishan, K., Krohn, K. J., Kugbey, N., Kumar, G. A., Kumar, M., Kumar, P., Kuupiel, D., Lacey, B., Lad, S. D., Lami, F. H., Larsson, A. O., Lee, P. H., Leili, M., Levine, A. J., Li, S., Lim, L. -L, Listl, S., Longbottom, J., Lopez, J. C. F., Lorkowski, S., Magdeldin, S., Abd El Razek, H. M., Abd El Razek, M. M., Majeed, A., Maleki, A., Malekzadeh, R., Malta, D. C., Mamun, A. A., Manafi, N., Manda, A. -L, Mansourian, M., Martins-Melo, F. R., Masaka, A., Massenburg, B. B., Maulik, P. K., Mayala, B. K., Mazidi, M., McKee, M., Mehrotra, R., Mehta, K. M., Meles, G. G., Mendoza, W., Menezes, R. G., Meretoja, A., Meretoja, T. J., Mestrovic, T., Miller, T. R., Miller-Petrie, M. K., Mills, E. J., Milne, G. J., Mini, G. K., Mir, S. M., Mirjalali, H., Mirrakhimov, E. M., Mohamadi, E., Mohammad, D. K., Darwesh, A. M., Mezerji, N. M. G., Mohammed, A. S., Mohammed, S., Mokdad, A. H., Molokhia, M., Monasta, L., Moodley, Y., Moosazadeh, M., Moradi, G., Moradi, M., Moradi, Y., Moradi-Lakeh, M., Moradinazar, M., Moraga, P., Morawska, L., Mosapour, A., Mousavi, S. M., Mueller, U. O., Muluneh, A. G., Mustafa, G., Nabavizadeh, B., Naderi, M., Nagarajan, A. J., Nahvijou, A., Najafi, F., Nangia, V., Ndwandwe, D. E., Neamati, N., Negoi, I., Negoi, R. I., Ngunjiri, J. W., Thi Nguyen, H. L., Nguyen, L. H., Nguyen, S. H., Nielsen, K. R., Ningrum, D. N. A., Nirayo, Y. L., Nixon, M. R., Nnaji, C. A., Nojomi, M., Noroozi, M., Nosratnejad, S., Noubiap, J. J., Motlagh, S. N., Ofori-Asenso, R., Ogbo, F. A., Oladimeji, K. E., Olagunju, A. T., Olfatifar, M., Olum, S., Olusanya, B. O., Oluwasanu, M. M., Onwujekwe, O. E., Oren, E., Ortega-Altamirano, D. D. V., Ortiz, A., Osarenotor, O., Osei, F. B., Osgood-Zimmerman, A. E., Otstavnov, S. S., Owolabi, M. O., Mahesh, P. A., Pagheh, A. S., Pakhale, S., Panda-Jonas, S., Pandey, A., Park, E. -K, Parsian, H., Pashaei, T., Patel, S. K., Pepito, V. C. F., Pereira, A., Perkins, S., Pickering, B. V., Pilgrim, T., Pirestani, M., Piroozi, B., Pirsaheb, M., Plana-Ripoll, O., Pourjafar, H., Puri, P., Qorbani, M., Quintana, H., Rabiee, M., Rabiee, N., Radfar, A., Rafiei, A., Rahim, F., Rahimi, Z., Rahimi-Movaghar, V., Rahimzadeh, S., Rajati, F., Raju, S. B., Ramezankhani, A., Ranabhat, C. L., Rasella, D., Rashedi, V., Rawal, L., Reiner Jr, R. C., Renzaho, A. M. N., Rezaei, S., Rezapour, A., Riahi, S. M., Ribeiro, A. I., Roever, L., Roro, E. M., Roser, M., Roshandel, G., Roshani, D., Rostami, A., Rubagotti, E., Rubino, S., Sabour, S., Sadat, N., Sadeghi, E., Saeedi, R., Safari, Y., Safari-Faramani, R., Safdarian, M., Sahebkar, A., Salahshoor, M. R., Salam, N., Salamati, P., Salehi, F., Zahabi, S. S., Salimi, Y., Salimzadeh, H., Salomon, J. A., Sambala, E. Z., Samy, A. M., Santric Milicevic, M. M., Jose, B. P. S., Saraswathy, S. Y. I., Sarmiento-SuÃ¡rez, R., Sartorius, B., Sathian, B., Saxena, S., Sbarra, A. N., Schaeffer, L. E., Schwebel, D. C., Sepanlou, S. G., Seyedmousavi, S., Shaahmadi, F., Shaikh, M. A., Shams-Beyranvand, M., Shamshirian, A., Shamsizadeh, M., Sharafi, K., Sharif, M., Sharif-Alhoseini, M., Sharifi, H., Sharma, J., Sharma, R., Sheikh, A., Shields, C., Shigematsu, M., Shiri, R., Shiue, I., Shuval, K., Siddiqi, T. J., Silva, J. P., Singh, J. A., Sinha, D. N., Sisay, M. M., Sisay, S., Sliwa, K., Smith, D. L., Somayaji, R., Soofi, M., Soriano, J. B., Sreeramareddy, C. T., Sudaryanto, A., Sufiyan, M. B., Sykes, B. L., Sylaja, P. N., TabarÃ©s-Seisdedos, R., Tabb, K. M., Tabuchi, T., Taveira, N., Temsah, M. -H, Terkawi, A. S., Tessema, Z. T., Thankappan, K. R., Thirunavukkarasu, S., To, Q. G., Tovani-Palone, M. R., Tran, B. X., Tran, K. B., Ullah, I., Usman, M. S., Uthman, O. A., Vahedian-Azimi, A., Valdez, P. R., van Boven, J. F. M., Vasankari, T. J., Vasseghian, Y., Veisani, Y., Venketasubramanian, N., Violante, F. S., Vladimirov, S. K., Vlassov, V., Vos, T., Vu, G. T., Vujcic, I. S., Waheed, Y., Wakefield, J., Wang, H., Wang, Y., Wang, Y. -P, Ward, J. L., Weintraub, R. G., Weldegwergs, K. G., Weldesamuel, G. T., Westerman, R., Wiysonge, C. S., Wondafrash, D. Z., Woyczynski, L., Wu, A. -M, Xu, G., Yadegar, A., Yamada, T., Yazdi-Feyzabadi, V., Yilgwan, C. S., Yip, P., Yonemoto, N., Lebni, J. Y., Younis, M. Z., Yousefifard, M., Yousof, H. -AS. A., Yu, C., Yusefzadeh, H., Zabeh, E., Moghadam, T. Z., Bin Zaman, S., Zamani, M., Zandian, H., Zangeneh, A., Zerfu, T. A., Zhang, Y., Ziapour, A., Zodpey, S., Murray, C. J. L., and Hay, S. I.
Abstract: Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2âto end preventable child deaths by 2030âwe need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000â2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations. Â© 2019, The Author(s).
Published: 2019
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5. Emerging Intestinal Microsporidia Infection in HIV+/AIDS Patients in Iran: Microscopic and Molecular Detection

Author: Mirjalali, H., Mohebali, M., Mirhendi, H., Gholami, R., Keshavarz, H., Ahmadreza Meamar, and Rezaeian, M.
Subjects: Encephalitozoon spp, fluids and secretions, Medical Sciences, Enterocytozoon bieneusi, Nested-PCR, fungi, parasitic diseases, HIV /AIDS patients, virus diseases, lcsh:RC109-216, Iran, HIV+/AIDS patients, lcsh:Infectious and parasitic diseases
Abstract: Background: Species of Microsporidia have been known as opportunistic obli-gate intracellular parasites particularly in immunocompromised patients. Enterocyto-zoon bieneusi is one of most prevalent intestinal microsporida parasites in HIV+/AIDS patients. In this study, intestinal microsporidia infection was deter-mined in HIV+/AIDS patients using microscopic and molecular methods. Methods: Stool samples were collected from HIV+/AIDS patients during 12 months. All of the stool specimens washed with PBS (pH: 7.5). Slim slides were prepared from each sample and were examined using light microscope with 1000X magnification. DNA extraction carried out in microscopic positive samples. DNA amplification and genus/species identification also performed by Nested-PCR and sequencing techniques. Results: From 81 stool samples, 25 were infected with microsporidia species and E. bieneusi were identified in all of positive samples. No Encephalitozoon spp. was identified in 81 collected samples using specific primers. Conclusion: E. bieneusi is the most prevalent intestinal microsporidia in immuno-compromised patients of Iran. On the other hand, Nested-PCR using specific pri-mers for ssu rRNA gene is an appropriate molecular method for identification of E. bieneusi.
Published: 2014

6. Microscopic and Molecular Detection of Cryptosporidium andersoni and Cryptosporidium xiaoi in Wastewater Samples of Tehran Prov-ince, Iran

Author: kareem Hatam-Nahavandi, Mohebali, M., Mahvi, A. -H, Keshavarz, H., Najafian, H. -R, Mirjalali, H., Rezaei, S., and Rezaeian, M.
Subjects: animal diseases, parasitic diseases, Cryptosporidium andersoni, Original Article, lcsh:RC109-216, Cryptosporidium xiaoi, Iran, Wastewater, lcsh:Infectious and parasitic diseases
Abstract: Background: As a waterborne pathogen, Cryptosporidium is one of the most common causes of gastroenteritis in human and hoofed livestock animals. This study aimed to investigate the distribution of Cryptosporidium spp. in human and livestock wastewaters in Iran, by the 18S rRNA sequence analysis. Methods: A total of 54 raw wastewater samples collected from three urban treatment plants and two slaughterhouses during 2014-2015 in Tehran, Iran. The presence of the Cryptosporidium oocysts was assessed by immunofluorescence with monoclonal antibodies. To characterize the oocysts at the molecular level, the 18S rRNA gene of Cryptosporidium was PCR amplified and sequenced. Results: Of the 54 wastewater samples examined, 34 (62.9%) were positive for Cryptosporidium oocysts using the IFA. Of these, 70.5% (24/34) were positive by PCR, that 91.6% (22/24) were successfully sequenced. The species of C. andersoni (95.4%) and C. xiaoi (4.6%) were detected in livestock wastewater samples. Conclusion: C. andersoni was the major Cryptosporidium sp. found in the aquatic environmental wastewater samples. The high rate of detection of C. andersoni in domestic wastewater was probably the result of the predominancy of this species in cattle herds in Iran. The current study is the first report of C. xiaoi in Iran.
Published: 2016

7. Helminth Parasites of Rhombomys Opimus from Golestan Province, Northeast Iran

Author: Kamranrashani, B., Kia, E. B., Mobedi, I., Mohebali, M., Zarei, Z., Mowlavi, G. H., Hajjaran, H., Abai, M. R., meysam sharifdini, Kakooei, Z., Mirjalali, H., and Charedar, S.
Subjects: Helminths, parasitic diseases, Rhombomis Opimus, Parasites, lcsh:RC109-216, Iran, lcsh:Infectious and parasitic diseases
Abstract: Background: The aim of the study was to determine the helminthic species occurring in great gerbil Rhombomys opimus collected from Maraveh Tappeh, Golestan Province, northeast Iran. Methods: During 2010-2011, a total of 77 R. opimus were captured from rural areas of Maraveh Tap-peh, Golestan Province, using Sherman live traps and examined for infectivity with any larva or adult stages of helminthic parasites. Results: Overall, 63 R. opimus (81.8%) were found infected with different helminthic species. The rate of infectivity with each species was as follows: Trichuris rhombomidis 31.2%, Trichuris muris 32.5%, Trichuris spp. 10.4%, Syphacia muris 2.6%, Dipetalonema viteae (Acanthocheilonema viteae) 37.7%, Skrjabinotaenia lobata 15.6%, Hymenolepis (=Rodentolepis) nana fraterna 5.2%, and Taenia endothoracicus lar-va 1.3%. Conclusion: R. opimus is host for several species of cestodes and nematodes in the study area. The high rate of infectivity with D. viteae indicates the susceptibility of these gerbils to this filarial nema-tode. Synchronous infections occurred up to four species of helminthes in one host.
Published: 2013

8. Small-scale risk assessment of transmission of parasites from wastewater treatment plant to downstream vegetable farms

Author: Javanmard, E., Mirjalali, H., Niyyati, M., meysam sharifdini, Jalilzadeh, E., Tabaei, S. J. S., Aghdaei, H. A., Rostami, R., Nazemalhosseini-Mojarad, E., Haghighi, A., and Zali, M. R.
Subjects: Treated wastewaters, Vegetable farms, Brief Report, Iran, Parasitic contamination, Irrigation
Abstract: Aim: The aim of the present study was to simultaneously investigate parasitic contamination of treated wastewater and downstream vegetable farms that are irrigated with treated sewage, during a year. Background: (Oo) Cysts and eggs of parasites are resistant to most of routine wastewater treatment process. Irrigation of vegetables farms with either treated wastewater or illegally use of raw wastewaters enhances the risk of contamination with enteric pathogens. Methods: The treated wastewater samples were taken after chlorination from a wastewater treatment plant located at the south of Tehran. In addition, 60 vegetable samples (5 samples from each farm) were collected from the selected downstream farms that routinely used treated wastewater for irrigation of crops. Parasitological tests were performed using Ziehl–Neelsen, conventional lugol’s iodine staining and direct microscopical examination. Results: Parasites including free living larvae, eggs of Toxoascaris leonina, egg of Toxocara sp. Trichuris sp, Trichostrongylus sp and amoeboid trophozoite were seen in 5/12 (41.7%) of vegetable samples gathered during a year. There was no statistically significant correlation between the season and parasitic contamination of the vegetables (P= 1). Furthermore, parasitic contamination was observed in 7/12 (53.8%) of treated wastewater samples. The correlation between season and parasitic contamination of treated wastewater was evaluated that the results showed a higher contamination of treated wastewater in spring and autumn (P

9. Prevalence and molecular aspects of human hookworms in Guilan Province, northern Iran

Author: meysam sharifdini, Ghanbarzadeh, L., Kouhestani-Maklavani, N., Mirjalali, H., and Saraei, M.
Subjects: Phylogenetic analysis, Necator americanus, parasitic diseases, Prevalence, lcsh:RC109-216, Original Article, Iran, lcsh:Infectious and parasitic diseases
Abstract: Background: Hookworm infection is one of the important Neglected Tropical Diseases (NTD) in the world. It was previously more prevalent in the northern and southern parts of Iran with a prevalence rate higher than 40% in some endemic regions; nevertheless, the infection rate has decreased to less than 1%. This study aimed to determine prevalence and molecular aspects of hookworm infections in rural inhabitants of Fouman County, Guilan Province, northern Iran Methods: This cross-sectional study was performed in 31 villages of Fouman district in Guilan Province, northern Iran during 2015-2016. Stool samples were collected from 1500 rural inhabitants and examined by formalin ethyl-acetate concentration as well as agar plate culture techniques. After treatment with albendazole, adult hookworms were isolated. FollowingDNA extraction,PCR amplification of ITS2-rDNA region was performed and the product was sequenced, followed by genetic variation analysis. Results: Of 1500 samples, one case was morphologically diagnosed as N. americanus. In addition, molecular characterization verified the presence of N. americanus, showing more than 95% similarity with sequences of N. americanus present in GenBank. The patient showed no clinical symptoms and a mild hypereosinophilia was the only laboratory finding observed. Conclusion: A reduced prevalence of human hookworms was demonstrated within Guilan Province located in north of Iran. The N. americanus originated from Guilan had a high homology with the isolates found in Japan, Laos, Malaysia, and Australia.

10. Immunocompromised patients with pulmonary tuberculosis; a susceptible group to intestinal parasites

Author: Taghipour, A., Taher Azimi, Javanmard, E., Pormohammad, A., Olfatifar, M., Rostami, A., Tabarsi, P., Sohrabi, M. R., Mirjalali, H., and Haghighi, A.
Subjects: Intestinal parasites, Short Communication, Immunodeficiency disorders, parasitic diseases, Tuberculosis, Iran
Abstract: Aim: To investigate the presence of intestinal parasites in tuberculosis patients who suffered from immunodeficiency disorders. Background: Tuberculosis is an important infectious disease that is endemic in some regions of Iran. However, there is a coverage in the endemicity areas of this infection with intestinal parasites. Methods: Stool samples were collected from 50 immunocompromised tuberculosis patients. Direct smear using the normal saline (0.85% NaCl solution) and Lugol’s iodine staining were performed to detect trophozoite of parasites. Moreover, stool samples were concentrated using routine formalin-ether to detect protozoan cysts and helminth’s ova/larvae. Specific staining techniques including Trichrome, Modified Ziehl-Neelsen and chromotrope 2R were employed to detect amoeba, Giardia spp., coccidian parasites and microsporidia. Results: From 50 participants, 42 (84%) and 8 (16%) were male and female, respectively. The mean age + SD of patients was 47.88 + 10.88 years. Among the participated patients, HIV positive, cancer, organ transplant and receiving corticosteroids were seen in 13, 10, 15 and 12 subjects, respectively. The prevalence of Intestinal parasites was 34 %( 17/50). Blastocystis (18%; 9/50), and intestinal helminth (Enterobius vermicularis) (2%; 1/50) were the most prevalent and less prevalent parasites, respectively. Statistical significance difference was not seen between presence of intestinal parasites and type of immunodeficiency. Conclusion: Our findings showed the high prevalence of intestinal parasites with majority of Blastocystis. Indeed, this study suggested that due to complicated immune conditions of TB patients with immunodeficiency disorders, this group of patients are at higher risk of infection by intestinal parasites.

11. Pathogenic assays of Acanthamoeba belonging to the T4 genotype

Author: Mirjalali, H., Niyyati, M., Abedkhojasteh, H., Babaei, Z., meysam sharifdini, and Rezaeian, M.
Subjects: Experimental Model, parasitic diseases, Osmotolerance, Pathogenicity, Rat, Original Article, lcsh:RC109-216, Acanthamoeba T4, lcsh:Infectious and parasitic diseases
Abstract: Background: Acanthamoeba genus is introduced as opportunistic and cosmopoli-tan parasite. Monkey and wistar rat are appropriate models for experimental study on Acanthamoeba infection. In this study Acanthamoeba spp. were isolated from hot spring (HS), windows dust (WD) and a corneal sample of keratitis patient (KP) and their pathogenicity surveyed by in vitro and in vivo tests. Methods: Isolates of Acanthamoeba were cultivated axenically for 12 months in PYG medium. Overall, 30 wistar rats, in 6 equal groups were used for developing experimental Acanthamoeba keratitis (AK) and Granulomatous Amoebic Encephalitis (GAE). The Keratitis and Granulomatous Encephalitis experiments were per-formed by intrastromal and intranasal inoculation of Acanthamoeba cysts, respec-tively. Pathogenicity of the three isolates was also evaluated by in vitro test using osmotolerance and temperature tolerance assays. Identification of genotypes were performed by PCR technique and sequencing. Result: None of the isolates could perform AK and GAE in wistar rats, although all isolates were described as T4 genotype. Isolates obtained from KP and WD could grow only in 30 °C, but not in 37 °C and 40 °C. On the other hand, HS iso-late grew in 30 °C and 37 °C but not in 40 °C. Moreover, all of isolate grew in 0.5 M mannitol but not in 1 M and 1.5 M. Conclusion: T4 isolates with a long-term axenic culture and different factors re-lated to host and parasite may play role in pathogenicity of these free-living amoebae.

12. Subtypes distribution and frequency of Blastocystis sp. Isolated from diarrheic and non-diarrheic patients

Author: Nahid Jalallou, Iravani, S., Rezaeian, M., Alinaghizade, A., and Mirjalali, H.
Subjects: Subtyping, fluids and secretions, Blastocystis sp, 18S rDNA, animal diseases, parasitic diseases, lcsh:RC109-216, Iran, lcsh:Infectious and parasitic diseases
Abstract: Background: Blastocystis is one of the most common parasites, reported from both human and animals. This parasite is more prevalent in regions with low levels of hygiene, close contact with animal and unsuitable disposal systems. The aim of the study was to subtype Blastocystis sp., isolated from diarrheic and non-diarrheic patients using sequencing of 18S ribosomal DNA. Methods: Totally, 300 stool samples were collected from diarrheic and non-diarrheic patients referred to Imam Reza Hospital, Tehran from Apr to Aug 2015. All samples were concentrated using conventional Formalin – ether technique and recognized under light microscope. The fresh stool samples were also cultivated in clotted fetal bovine medium and examined for growing of Blastocystis every 48 h with direct smear slides for 10 d.DNA extraction was performed on all positive samples. Amplified DNA fragment of 18S rDNA was sequenced and compared with reference genes, previously deposited in Genbank database. Results: The number of diarrheic and non-diarrheic patients participated in the study was 134 (44.66%) and 166 (55.34%), respectively. Three subtypes 1, 2, 3 were identified from positive samples. Subtype 2 was the most prevalent (36.5%) followed by subtype 1 (33.3%) and subtype 3 (30.2%). There were no mixed subtypes. Furthermore, the most prevalent subtypes in diarrheic and non-diarrheic patients were subtype 2 (39.28%) and subtype 1 (37.14%), respectively. Conclusion: Blastocystis sp., is one of the most prevalent unicellular parasites among diarrheic and non-diarrheic patients. Indeed, ST2 was the most prevalent subtype particularly in those samples collected from diarrheic patients.

13. Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Author: Kinyoki, Damaris K., Ross, Jennifer M., Lazzar-Atwood, Alice, Munro, Sandra B., Schaeffer, Lauren E., Abbasalizad-Farhangi, Mahdieh, Abbasi, Masoumeh, Abbastabar, Hedayat, Abdelalim, Ahmed, Abdoli, Amir, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abebe, Nebiyu Dereje, Abebo, Teshome Abuka, Abegaz, Kedir Hussein, Abolhassani, Hassan, Abreu, Lucas Guimarães, Abrigo, Michael R. M., Abushouk, Abdelrahman I., Accrombessi, Manfred Mario Kokou, Acharya, Dilaram, Adabi, Maryam, Adebiyi, Akindele Olupelumi, Adedeji, Isaac Akinkunmi, Adekanmbi, Victor, Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O., Adham, Davoud, Aduroja, Posi Emmanuel, Advani, Shailesh M., Afarideh, Mohsen, Aghaali, Mohammad, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadi, Sepideh, Ahmed, Muktar Beshir, Ahmed, Rushdia, Ajumobi, Olufemi, Akal, Chalachew Genet, Akalu, Temesgen Yihunie, Akinyemiju, Tomi, Akombi, Blessing, Al-Aly, Ziyad, Alam, Samiah, Alamene, Genet Melak, Alanzi, Turki M., Rabanal, Jacqueline Elizabeth Alcalde, Alema, Niguse Meles, Ali, Beriwan Abdulqadir, Ali, Muhammad, Alijanzadeh, Mehran, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Almasi, Afshin, Almasi-Hashiani, Amir, Al-Mekhlafi, Hesham M., Al-Raddadi, Rajaa M., Altirkawi, Khalid, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J., Amare, Azmeraw T., Amegah, Adeladza Kofi, Amini, Saeed, Rarani, Mostafa Amini, Amiri, Fatemeh, Amit, Arianna Maever Loreche, Anber, Nahla Hamed, Andrei, Catalina Liliana, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Anteneh, Zelalem Alamrew, Antonio, Carl Abelardo T., Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-Zozani, Morteza, Araya, Ephrem Mebrahtu, Arefi, Zohreh, Aremu, Olatunde, Ärnlöv, Johan, Arzani, Afsaneh, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A., Asgari, Samaneh, Asghari, Babak, Ashagre, Alebachew Fasil, Asrat, Anemaw A., Ataeinia, Bahar, Atalay, Hagos Tasew, Atnafu, Desta Debalkie, Atout, Maha Moh’d Wahbi, Ausloos, Marcel, Avokpaho, Euripide F. G. A., Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Ayanore, Martin Amogre, Aynalem, Yared A. Asmare, Azadmehr, Abbas, Azari, Samad, Azarian, Ghasem, Azene, Zelalem Nigussie, Babaee, Ebrahim, Badawi, Alaa, Badiye, Ashish D., Bahrami, Mohamad Amin, Baig, Atif Amin A., Bakhtiari, Ahad, Bakkannavar, Shankar M., Balakrishnan, Senthilkumar, Bali, Ayele Geleto, Banach, Maciej, Banik, Palash Chandra, Baradaran-Seyed, Zahra, Baraki, Adhanom Gebreegziabher, Barboza, Miguel A., Bärnighausen, Till Winfried, Barua, Lingkan, Basaleem, Huda, Basu, Sanjay, Bayati, Mohsen, Bayih, Mulat Tirfie, Baynes, Habtamu Wondifraw, Bedi, Neeraj, Behzadifar, Masoud, Behzadifar, Meysam, Bekele, Yibeltal Alemu, Bennett, Derrick A., Berbada, Dessalegn Ajema, Berhe, Kidanemaryam, Berhe, Abadi Kidanemariam, Berman, Adam E., Bernstein, Robert S., Bhageerathy, Reshmi, Bhandari, Dinesh, Bharadwaj, Pankaj, Bhattacharjee, Natalia V., Bhattacharyya, Krittika, Bijani, Ali, Bikbov, Boris, Bilano, Ver, Bililign, Nigus, Sayeed, Muhammad Shahdaat Bin, Birara, Setognal, Birhane, Minuye Biniam Biniam, Birhanu, Minyichil, Biswas, Raaj Kishore, Bitew, Zebenay Workneh, Bogale, Kassawmar Angaw, Bohlouli, Somayeh, Bolla, Srinivasa Rao, Boloor, Archith, Borzì, Antonio M., Borzouei, Shiva, Brady, Oliver J., Bragazzi, Nicola Luigi, Braithwaite, Dejana, Briko, Nikolay Ivanovich, Britton, Gabrielle, Budhathoki, Shyam S., Nagaraja, Sharath Burugina, Busse, Reinhard, Butt, Zahid A., Cahuana-Hurtado, Lucero, Cámera, Luis Alberto, Campos-Nonato, Ismael R., Cano, Jorge, Car, Josip, Cárdenas, Rosario, Carrero, Juan J., Carvalho, Félix, Castaldelli-Maia, João Mauricio, Castañeda-Orjuela, Carlos A., Castro, Franz, Cerin, Ester, Chansa, Collins, Charan, Jaykaran, Chatterjee, Pranab, Chattu, Vijay Kumar, Chauhan, Bal Govind, Chavshin, Ali Reza, Chehrazi, Mohammad, Chichiabellu, Tesfaye Yitna, Chin, Ken Lee, Christopher, Devasahayam J., Chu, Dinh-Toi, Cicuttini, Flavia M., Collison, Michael L., Cork, Michael A., Cormier, Natalie, Cortesi, Paolo Angelo, Costa, Vera M., Dadi, Abel Fekadu Fekadu, Dagnew, Baye, Dahlawi, Saad M. A., Damiani, Giovanni, Darwish, Amira Hamed, Daryani, Ahmad, Das, Jai K., Gupta, Rajat Das, Dávila-Cervantes, Claudio, Davis Weaver, Nicole, Leo, Diego De, Neve, Jan-Walter De, Demeke, Feleke Mekonnen, Demis, Asmamaw Bizuneh, Demissie, Dereje Bayissa, Demoz, Gebre Teklemariam, Denova-Gutiérrez, Edgar, Deribe, Kebede, Desai, Rupak, Desalegn, Beruk Berhanu, Desalew, Assefa, Deshpande, Aniruddha, Dey, Sagnik, Dharmaratne, Samath Dhamminda, Dhillon, Preeti, Dhimal, Meghnath, Dhungana, Govinda Prasad, Nasab, Mostafa Dianati, Diaz, Daniel, Forooshani, Zahra Sadat Dibaji, Dinsa, Girmaye Deye, Dipeolu, Isaac Oluwafemi, Djalalinia, Shirin, Do, Hoa Thi, Do, Huyen Phuc, Doku, Paul Narh, Dorostkar, Fariba, Doshmangir, Leila, Dubey, Manisha, Adema, Bereket Duko, Dunachie, Susanna J., Duncan, Bruce B., Cousin, Ewerton, Durães, Andre R., Earl, Lucas, Leylabadlo, Hamed Ebrahimzadeh, Eftekhari, Aziz, El Sayed, Iman, El Sayed Zaki, Maysaa, El Tantawi, Maha, Elbarazi, Iffat, Elemineh, Demelash Abewa, El-Jaafary, Shaimaa I., El-Khatib, Ziad, Elsharkawy, Aisha, El-Sherbiny, Yasser Mohamed, Elyazar, Iqbal R. F., Emamian, Mohammad Hassan, Enany, Shymaa, Endalew, Daniel Adane, Endalifer, Melese Linger, Eskandari, Khalil, Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esteghamati, Alireza, Etemadi, Arash, Etisso, Atkilt Esaiyas, Fanzo, Jessica, Farahmand, Mohammad, Faraj, Anwar, Farashi, Sajjad, Fareed, Mohammad, Farioli, Andrea, Faro, Andre, Farzadfar, Farshad, Farzam, Hossein, Fatima, Syeda Sadia, Fattahi, Nazir, Fauk, Nelsensius Klau, Fazaeli, Ali Akbar, Fentahun, Netsanet, Ferede, Tomas Y., Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Fernandes, João C., Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Flohr, Carsten, Foigt, Nataliya A., Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Foroutan, Masoud, Förster, Jana, Francis, Joel Msafiri, Fukumoto, Takeshi, Gayesa, Reta Tsegaye, Geberemariyam, Biniyam Sahiledengle, Gebrehiwot, Tsegaye Tewelde, Gebremariam, Hadush, Gebremariam, Kidane Tadesse, Gebremedhin, Ketema Bizuwork Bizuwork, Gebremeskel, Gebreamlak Gebremedhn, Gebreslassie, Assefa Ayalew Ayalew, Gebretsadik, Gebretsadkan G. G., Gedefaw, Getnet Azeze, Geramo, Yilma Chisha Dea, Gesesew, Hailay Abrha, Geta, Birhanu, Getenet, Agegnehu Bante, Gezae, Kebede Embaye, Ghaffarifar, Fatemeh, Ghafourifard, Mansour, Ghajar, Alireza, Ghajarzadeh, Mahsa, Ghashghaee, Ahmad, Ghiasvand, Hesam, Gholamian, Asadollah, Gilani, Syed Amir, Gill, Tiffany K., Ginawi, Ibrahim Abdelmageed, Goli, Srinivas, Gomes, Nelson G. M., Gopalani, Sameer Vali, Goudarzi, Houman, Goulart, Alessandra C., Govindakarnavar, Arunkumar, Grada, Ayman, Grivna, Michal, Guimarães, Rafael Alves, Guled, Rashid Abdi, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Hafezi-Nejad, Nima, Haile, Michael Tamene, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hall, Brian J., Halvaei, Iman, Hamadeh, Randah R., Hamidi, Yadollah, Handiso, Demelash Woldeyohannes, Hankey, Graeme J., Haririan, Hamidreza, Hariyani, Ninuk, Hasaballah, Ahmed I., Hasan, Md. Mehedi, Hasankhani, Milad, Hasanpoor, Edris, Hasanzadeh, Amir, Hashemian, Maryam, Hassanipour, Soheil, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hawkes, Corinna, Hayat, Khezar, Hayelom, Desta Haftu, Heidari, Behnam, Heidari-Soureshjani, Reza, Hendrie, Delia, Henok, Andualem, Henry, Nathaniel J., Herrero, Mario, Herteliu, Claudiu, Heydarpour, Fatemeh, de Hidru, Hagos D., Hoang, Chi Linh, Hoek, Hans W., Hole, Michael K., Holla, Ramesh, Hollerich, Gillian, Rad, Enayatollah Homaie, Hong, Sung Hwi, Hoogar, Praveen, Horino, Masako, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hsairi, Mohamed, Hu, Guoqing, Huda, Tanvir M., Humayun, Ayesha, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Milena D., Imani-Nasab, Mohammad Hasan, Inbaraj, Leeberk Raja, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Iwu, Chidozie C. D., Iwu, Chinwe Juliana, Izadi, Neda, Jaafari, Jalil, Jaca, Anelisa, Jadidi-Niaragh, Farhad, Balalami, Nader Jafari, Jafarinia, Morteza, Jahani, Mohammad Ali, Jakovljevic, Mihajlo, Jalali, Amir, Jalilian, Farzad, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jehan, Fyezah, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S., Jia, Peng, John, Oommen, John-Akinola, Yetunde O., Johnson, Kimberly B., Jonas, Jost B., Joseph, Nitin, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jungari, Suresh Banayya, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Kahsay, Amaha, Kahssay, Molla, Kalani, Hamed, Kalankesh, Leila L., Kalhor, Rohollah, Kamiab, Zahra, Kanchan, Tanuj, Kapil, Umesh, Kapoor, Neeti, Karami, Manoochehr, Matin, Behzad Karami, Karch, André, Karim, Mohd A., Karki, Surendra, Kasaeian, Amir, Kasahun, Gebremicheal Gebreslassie, Kasaye, Habtamu Kebebe, Kassa, Tesfaye Dessale, Kassaye, Hagazi Gebremedhin, Kassebaum, Nicholas J., Karyani, Ali Kazemi, Kengne, Andre Pascal, Ketema, Daniel Bekele, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khaksarian, Mojtaba, Khalid, Nauman, Khalil, Ibrahim A., Khalilov, Rovshan, Khan, Asad, Khan, Ejaz Ahmad, Khan, Md Nuruzzaman, Khan, Mohammad Saud, Khan, Muhammad Shahzeb, Khatab, Khaled, Khater, Amir, Khater, Mona M., Khatib, Mahalqua Nazli, Khayamzadeh, Maryam, Khazaei-Pool, Maryam, Khazaei, Mohammad, Khazaei, Salman, Khodayari, Mohammad Taghi, Khosravi, Mohammad Hossein, Khundkar, Roba, Kiadaliri, Ali, Kianipour, Neda, Kiirithio, Daniel N., Kim, Yun Jin, Kimokoti, Ruth W., Kisa, Adnan, Kisa, Sezer, Kolola, Tufa, Komaki, Hamidreza, Kondlahalli, Shivakumar K. M., Koolivand, Ali, Koul, Parvaiz A., Koyanagi, Ai, Kraemer, Moritz U. G., Krishan, Kewal, Krohn, Kris J., Kugbey, Nuworza, Kumar, Manasi, Kumar, Pushpendra, Kumar, Vivek, Kurmi, Om P., Kuti, Oluwatosin, Vecchia, Carlo La, Lacey, Ben, Lad, Deepesh P., Lal, Aparna, Lal, Dharmesh Kumar, Lami, Faris Hasan, Lamichhane, Prabhat, Lang, Justin J., Lansingh, Van C., Lasrado, Savita, Lebedev, Georgy, Lee, Paul H., Lee, Shaun Wen Huey, Leili, Mostafa, Letourneau, Ian D., Lewycka, Sonia, Li, Shanshan, Lim, Lee-Ling, Linn, Shai, Liu, Shiwei, Liu, Simin, Lodha, Rakesh, Longbottom, Joshua, Lopez, Jaifred Christian F., Lorkowski, Stefan, Macarayan, Erlyn Rachelle King, Madadin, Mohammed, El Razek, Hassan Magdy Abd, El Razek, Muhammed Magdy Abd, Maghavani, Dhaval P., Mahasha, Phetole Walter, Mahotra, Narayan Bahadur, Maled, Venkatesh, Maleki, Afshin, Maleki, Shokofeh, Malta, Deborah Carvalho, Manafi, Ali, Manafi, Farzad, Manafi, Navid, Manohar, Narendar Dawanu, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Marami, Dadi, Marczak, Laurie B., Arnedo, Carlos Alberto Marrugo, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Massenburg, Benjamin Ballard, Maulik, Pallab K., Mayala, Benjamin K., Mazidi, Mohsen, Mehndiratta, Man Mohan, Mehri, Freshteh, Mehta, Kala M., Meitei, Wahengbam Bigyananda, Mekonnen, Fantahun Ayenew, Mekonnen, Teferi, Meles, Gebrekiros Gebremichael, Meles, Hagazi Gebre, Melese, Addisu, Mendoza, Walter, Menezes, Ritesh G., Mengesha, Meresa Berwo, Mensah, George A., Meretoja, Tuomo J., Miazgowski, Tomasz, Kostova, Neda Milevska, Miller, Ted R., Mills, Edward J., Mini, G. K., Mir, Seyed Mostafa, Miri, Mohammad, Mirjalali, Hamed, Mirrakhimov, Erkin M., Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei, Roya, Mirzaei-Alavijeh, Mehdi, Mithra, Prasanna, Moazen, Babak, Mohamadi, Efat, Mohamadi-Bolbanabad, Amjad, Mohammad, Karzan Abdulmuhsin, Mohammad, Yousef, Mohammad, Dara K., Darwesh, Aso Mohammad, Mezerji, Naser Mohammad Gholi, Mohammadian-Hafshejani, Abdollah, Mohammadnia-Afrouzi, Mousa, Mohammadoo-Khorasani, Milad, Mohammadpourhodki, Reza, Mohammed, Salahuddin, Mohammed, Shafiu, Mohammed, Jemal Abdu, Mohammed, Ammas Siraj, Mohebi, Farnam, Mokari, Amin, Mokdad, Ali H., Montañez, Julio Cesar, Montero-Zamora, Pablo A., Moodley, Yoshan, Moossavi, Maryam, Moradi, Ghobad, Moradi, Masoud, Moradi, Yousef, Moradi-Joo, Mohammad, Moradi-Lakeh, Maziar, Moradpour, Farhad, Moradzadeh, Rahmatollah, Moraga, Paula, Morrison, Shane Douglas, Mosapour, Abbas, Mosser, Jonathan F., Mouodi, Simin, Khaneghah, Amin Mousavi, Mozaffarian, Dariush, Mueller, Ulrich Otto, Murray, Christopher J. L., Murthy, G. V. S., Musa, Kamarul Imran, Mustafa, Ghulam, Muthupandian, Saravanan, Nabavizadeh, Behnam, Naderi, Mehdi, Nadkarni, Girish N., Nagarajan, Ahamarshan Jayaraman, Naghavi, Mohsen, Naheed, Aliya, Naik, Gurudatta, Najafi, Farid, Nansseu, Jobert Richie, Narayan, K. M. Venkat, Nascimento, Bruno Ramos, Nayak, Vinod, Nazari, Javad, Ndwandwe, Duduzile Edith, Negoi, Ionut, Negoi, Ruxandra Irina, Ngunjiri, Josephine W., Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nigatu, Dabere, Nigatu, Yeshambel T., Nikbakhsh, Rajan, Ningrum, Dina Nur Anggraini, Nnaji, Chukwudi A., Nong, Vuong Minh, Noubiap, Jean Jacques, Nowak, Christoph, Oancea, Bogdan, Ofori-Asenso, Richard, Oghenetega, Onome Bright, Oh, In-Hwan, Oladimeji, Olanrewaju, Oladnabi, Morteza, Olagunju, Andrew T., Olagunju, Tinuke O., Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Oluwasanu, Mojisola Morenike, Omer, Muktar Omer, Onwujekwe, Obinna E., Asante, Kwaku Oppong, Oren, Eyal, Orisakwe, Orish Ebere, Ortiz, Alberto, Osarenotor, Osayomwanbo, Osgood-Zimmerman, Aaron E., Owolabi, Mayowa Ojo, P. A., Mahesh, Padubidri, Jagadish Rao, Pakshir, Keyvan, Pana, Adrian, Panda-Jonas, Songhomitra, Parsian, Hadi, Pashaei, Tahereh, Pasupula, Deepak Kumar, Patel, Sangram Kishor, Pathak, Ashish, Pathak, Mona, Pati, Sanghamitra, Patle, Ajay, Patton, George C., Paulos, Kebreab, Toroudi, Hamidreza Pazoki, Pepito, Veincent Christian Filipino, Perico, Norberto, Petri, William A., Pickering, Brandon V., Pigott, David M., Pirestani, Majid, Piroozi, Bakhtiar, Pirsaheb, Meghdad, Pokhrel, Khem Narayan, Postma, Maarten J., Pourjafar, Hadi, Pourmalek, Farshad, Kalhori, Reza Pourmirza, Pourshams, Akram, Poustchi, Hossein, Prada, Sergio I., Preotescu, Liliana, Pribadi, Dimas Ria Angga, Syed, Zahiruddin Quazi, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Muhammad Aziz, Rahman, Sajjad ur, Rai, Rajesh Kumar, Rajabpour-Sanati, Ali, Rajati, Fatemeh, Ramezanzadeh, Kiana, Rana, Saleem Muhammad, Ranabhat, Chhabi Lal, Rao, Sowmya J., Rasella, Davide, Rashedi, Vahid, Rastogi, Prateek, Rathi, Priya, Rawaf, Salman, Rawaf, David Laith, Rawal, Lal, Ray, Sarah E., Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M. N., Resnikoff, Serge, Rezaei, Nima, Rezaeian, Shahab, Rezai, Mohammad Sadegh, Rezapour, Aziz, Riahi, Seyed Mohammad, Ribeiro, Ana Isabel, Rickard, Jennifer, Rodriguez, Alina, Roever, Leonardo, Roro, Elias Merdassa, Roshandel, Gholamreza, Rostami, Ali, Rubagotti, Enrico, Saad, Anas M., Saadatagah, Seyedmohammad, Sabde, Yogesh Damodar, Sabour, Siamak, Sadeghi, Ehsan, Sadeghi, Masoumeh, Safari, Saeed, Safari, Yahya, Safarpour, Hamid, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, S. Mohammad, Salahshoor, Mohammad Reza, Salam, Nasir, Salehi, Farkhonde, Zahabi, Saleh Salehi, Salem, Hosni, Salem, Marwa R. 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Departamento de Medicina, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP), Veritati - Repositório Institucional da Universidade Católica Portuguesa, Biosciences, University of Helsinki, Clinicum, HUS Comprehensive Cancer Center, Institute for Molecular Medicine Finland, Department of Earth Observation Science, UT-I-ITC-ACQUAL, Faculty of Geo-Information Science and Earth Observation, Sálfræðideild (HR), Department of Psychology (RU), Samfélagssvið (HR), School of Social Sciences (RU), Háskólinn í Reykjavík, Reykjavik University, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD), Kinyoki, D, Ross, J, Lazzar-Atwood, A, Munro, S, Schaeffer, L, Abbasalizad-Farhangi, M, Abbasi, M, Abbastabar, H, Abdelalim, A, Abdoli, A, Abdollahi, M, Abdollahpour, I, Abdulkader, R, Abebe, N, Abebo, T, Abegaz, K, Abolhassani, H, Abreu, L, Abrigo, M, Abushouk, A, Accrombessi, M, 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S, Kasaeian, A, Kasahun, G, Kasaye, H, Kassa, T, Kassaye, H, Kassebaum, N, Karyani, A, Kengne, A, Ketema, D, Khader, Y, Khafaie, M, Khaksarian, M, Khalid, N, Khalil, I, Khalilov, R, Khan, A, Khan, E, Khan, M, Khatab, K, Khater, A, Khater, M, Khatib, M, Khayamzadeh, M, Khazaei-Pool, M, Khazaei, M, Khazaei, S, Khodayari, M, Khosravi, M, Khundkar, R, Kiadaliri, A, Kianipour, N, Kiirithio, D, Kim, Y, Kimokoti, R, Kisa, A, Kisa, S, Kolola, T, Komaki, H, Kondlahalli, S, Koolivand, A, Koul, P, Koyanagi, A, Kraemer, M, Krishan, K, Krohn, K, Kugbey, N, Kumar, M, Kumar, P, Kumar, V, Kurmi, O, Kuti, O, Vecchia, C, Lacey, B, Lad, D, Lal, A, Lal, D, Lami, F, Lamichhane, P, Lang, J, Lansingh, V, Lasrado, S, Lebedev, G, Lee, P, Lee, S, Leili, M, Letourneau, I, Lewycka, S, Li, S, Lim, L, Linn, S, Liu, S, Lodha, R, Longbottom, J, Lopez, J, Lorkowski, S, Macarayan, E, Madadin, M, El Razek, H, El Razek, M, Maghavani, D, Mahasha, P, Mahotra, N, Maled, V, Maleki, A, Maleki, S, Malta, D, Manafi, A, Manafi, F, Manafi, N, Manohar, N, Mansour-Ghanaei, F, Mansouri, B, Mansournia, M, Mapoma, C, Marami, D, Marczak, L, Arnedo, C, Martins-Melo, F, Masaka, A, Massenburg, B, Maulik, P, Mayala, B, Mazidi, M, Mehndiratta, M, Mehri, F, Mehta, K, Meitei, W, Mekonnen, F, Mekonnen, T, Meles, G, Meles, H, Melese, A, Mendoza, W, Menezes, R, Mengesha, M, Mensah, G, Meretoja, T, Miazgowski, T, Kostova, N, Miller, T, Mills, E, Mini, G, Mir, S, Miri, M, Mirjalali, H, Mirrakhimov, E, Mirzaei, H, Mirzaei, M, Mirzaei, R, Mirzaei-Alavijeh, M, Mithra, P, Moazen, B, Mohamadi, E, Mohamadi-Bolbanabad, A, Mohammad, K, Mohammad, Y, Mohammad, D, Darwesh, A, Mezerji, N, Mohammadian-Hafshejani, A, Mohammadnia-Afrouzi, M, Mohammadoo-Khorasani, M, Mohammadpourhodki, R, Mohammed, S, Mohammed, J, Mohammed, A, Mohebi, F, Mokari, A, Mokdad, A, Montanez, J, Montero-Zamora, P, Moodley, Y, Moossavi, M, Moradi, G, Moradi, M, Moradi, Y, Moradi-Joo, M, Moradi-Lakeh, M, Moradpour, F, Moradzadeh, R, Moraga, P, Morrison, S, Mosapour, A, Mosser, J, Mouodi, S, Khaneghah, A, Mozaffarian, D, Mueller, U, Murray, C, Murthy, G, Musa, K, Mustafa, G, Muthupandian, S, Nabavizadeh, B, Naderi, M, Nadkarni, G, Nagarajan, A, Naghavi, M, Naheed, A, Naik, G, Najafi, F, Nansseu, J, Narayan, K, Nascimento, B, Nayak, V, Nazari, J, Ndwandwe, D, Negoi, I, Negoi, R, Ngunjiri, J, Nguyen, C, Nguyen, H, Nigatu, D, Nigatu, Y, Nikbakhsh, R, Ningrum, D, Nnaji, C, Nong, V, Noubiap, J, Nowak, C, Oancea, B, Ofori-Asenso, R, Oghenetega, O, Oh, I, Oladimeji, O, Oladnabi, M, Olagunju, A, Olagunju, T, Olusanya, B, Olusanya, J, Oluwasanu, M, Omer, M, Onwujekwe, O, Asante, K, Oren, E, Orisakwe, O, Ortiz, A, Osarenotor, O, Osgood-Zimmerman, A, Owolabi, M, P. 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Subjects: Male, Local patterns, Double burden, Börn, Research & Experimental Medicine, Sjúkdómseinkenni, DOUBLE BURDEN, Childhood overweight, Lífefnafræði, Læknisfræði, 0302 clinical medicine, Syndemic, Child, 11 Medical and Health Sciences, under 5 years of age, General Medicine, 3. Good health, Geography, Medicine, Research & Experimental, Child, Preschool, Income, GROWTH, AFRICA, medicine.medical_specialty, Biochemistry & Molecular Biology, RJ, Medicina, Immunology, education, MODELS, wa_395, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Humans, Author Correction, Developing Countries, Poverty, Biology, LBD Double Burden of Malnutrition Collaborators, Demography, Science & Technology, Wasting Syndrome, Public health, MORTALITY, Infant, Næringarskortur, medicine.disease, Obesity, TRENDS, signs and symptoms, Social Class, Risk factors, Sameindalíffræði, ITC-ISI-JOURNAL-ARTICLE, UNDERNUTRITION, Human medicine, Clinical Medicine, 030217 neurology & neurosurgery, Pediatric Obesity, obesity, Offita, Áhættuþættir, Geographic Mapping, Overweight, RA0421, Global health, risk factors, 030212 general & internal medicine, Signs and symptoms, Wasting, Malnutrition, Global Burden of Diseases, Global Nutrition, low- and middle-income countries, 2. Zero hunger, 1. No poverty, Public Health, Global Health, Social Medicine and Epidemiology, A900 Others in Medicine and Dentistry, Childhood wasting, PREVALENCE, Chemistry, Mapping, Female, Lýðheilsa, medicine.symptom, Life Sciences & Biomedicine, GROWTH FAILURE, Nutritional Status, malnutrition, ITC-HYBRID, ws_115, children, Environmental health, medicine, Erfðafræði, wd_200, Malnutrition, Infant, Newborn, Klinisk medicin, Cell Biology, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, 3121 General medicine, internal medicine and other clinical medicine, NA
Abstract: Artículo con numerosos autores, sólo se mencionan el primero, los de la UAM y grupo colectivo, A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of, This work was primarily supported by grant OPP1132415 from the Bill & Melinda Gates Foundation awarded to S.I.H.
Published: 2020

14. Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

Author: Mohsen Bayati, Arvin Haj-Mirzaian, Mehran Asadi-Aliabadi, Maziar Moradi-Lakeh, Nasir Salam, Mohamad-Hani Temsah, Fatemeh Heydarpour, Davide Rasella, Kavumpurathu Raman Thankappan, Ghulam Mustafa, Sergey Konstantinovitch Vladimirov, Fereshteh Ansari, Dina Nur Anggraini Ningrum, Leonardo Roever, Oghenowede Eyawo, Koustuv Dalal, Ana-Laura Manda, Ritesh G. Menezes, Molly K. Miller-Petrie, Javad Yoosefi Lebni, Gebreamlak Gebremedhn Gebremeskel, Aziz Eftekhari, Oleguer Plana-Ripoll, Jon Wakefield, Sanjay Zodpey, Birhanu Geta, Amaha Kahsay, Edris Hasanpoor, Brijesh Sathian, Kala M. Mehta, Moritz U. G. Kraemer, Saeed Amini, Hesham M. Al-Mekhlafi, Abbas Yadegar, João Pedro Silva, Desmond Kuupiel, Anvar Asadi, Hamid Sharifi, Ebrahim Babaee, Dessalegn Ajema Berbada, Taddese Alemu Zerfu, Ian Davis, Mostafa Qorbani, Fatemeh Rajati, Samer Hamidi, Parvaiz A Koul, Foad Abd-Allah, Mojisola Oluwasanu, Syed Mohamed Aljunid, Elias Merdassa Roro, Mihaela Hostiuc, Robert S. Bernstein, Vahid Yazdi-Feyzabadi, Gebre Teklemariam Demoz, Irina Filip, Mu'awiyyah Babale Sufiyan, Amir Khater, Lidia Morawska, Sangram Kishor Patel, Robert C. Reiner, Joshua O. Akinyemi, Telma Zahirian Moghadam, Ali Akbar Fazaeli, Reza Malekzadeh, Olatunde Aremu, Mohammad Reza Salahshoor, Irfan Ullah, Gabrielle B. Britton, Gelin Xu, Nathaniel J Henry, Thomas R. Hird, Ronny Westerman, Vera Marisa Costa, Reza Assadi, Tiffany K. Gill, Chhabi Lal Ranabhat, Meysam Olfatifar, Sezer Kisa, Grant Rodgers Kemp, Mahmoud Yousefifard, Aleksandra Barac, Simon I. Hay, Walter Mendoza, Mohammad Zamani, Nader Jafari Balalami, Mahdi Safdarian, Manfred S. Green, Mahesh P A, Nahid Neamati, Pallab K. Maulik, Ali H. Mokdad, Joshua Longbottom, Somayeh Bohlouli, Ahmad Daryani, Ibrahim Abdollahpour, Mostafa Hosseini, Deborah Carvalho Malta, Nick Golding, Sheikh Mohammed Shariful Islam, Shirin Nosratnejad, Haidong Wang, Shadi Rahimzadeh, Pushpendra Kumar, Mehdi Noroozi, Andre M. N. Renzaho, Brent Bell, Huong Lan Thi Nguyen, Khaled Khatab, Meghdad Pirsaheb, Yousef Veisani, Katie R Nielsen, Ionut Negoi, Seyyed Meysam Mousavi, Amir Ashraf-Ganjouei, Mohammad Hassan Emamian, Joseph L Ward, Sharath Burugina Nagaraja, Songhomitra Panda-Jonas, Ettore Beghi, Azeem Majeed, Ivy Shiue, Delia Hendrie, Roghiyeh Faridnia, Seyed Mostafa Mir, Moslem Soofi, Ghobad Moradi, Mahsa Ghajarzadeh, Chandrashekhar T Sreeramareddy, Milad Hasankhani, Mohamed I Hegazy, Mika Shigematsu, Bryan L. Sykes, Vahid Alipour, Ruth W Kimokoti, Afshin Maleki, Nafiseh Baheiraei, Noore Alam, Jalal Arabloo, Mariam Molokhia, Kimberly B. Johnson, Amber Sligar, Nicole Davis Weaver, Kerem Shuval, Malede Mequanent Sisay, Paul H. Lee, Reza Ghadimi, Mahbobeh Faramarzi, Natalia V. Bhattacharjee, Ehsan Sadeghi, Brandon V. Pickering, Animika Pandey, Ana Isabel Ribeiro, Felix Greaves, Sameer Vali Gopalani, Joel M. Francis, Alyssa N. Sbarra, Yun Jin Kim, Agus Sudaryanto, Hebat Allah Salah A. Yousof, Hadi Pourjafar, Tomohide Yamada, Alireza Rafiei, Rosario Cárdenas, Mohammad Khazaei, Hasan Yusefzadeh, Rahman Shiri, Girmay Teklay Weldesamuel, Zahra Jorjoran Shushtari, Michael Collison, Stanislav S. Otstavnov, Narayanaswamy Venketasubramanian, Yahya Salimi, Naohiro Yonemoto, Ahmad Ghashghaee, Soewarta Kosen, Al Artaman, Surendra Karki, Tariq Jamal Siddiqi, Lorenzo Monasta, Amit Arora, Christopher S Yilgwan, Ahamarshan Jayaraman Nagarajan, Adnan Kisa, Gholamreza Roshandel, Vahid Rashedi, Daniel Diaz, Amir Vahedian-Azimi, Erkin M. Mirrakhimov, Nuworza Kugbey, Zohreh Arefi, Benjamin B. Massenburg, Robert G. Weintraub, Lauren E. Schaeffer, Alexandre C. Pereira, Mehdi Hosseinzadeh, Milena M Santric Milicevic, Ai Koyanagi, Mehran Shams-Beyranvand, Salman Khazaei, Olalekan A. 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C.J.L., and Hay S.I.
Subjects: Survival, RJ101, Mortalidad Infantil, HB, UNDER-5 MORTALITY, Global Health, Pediatrics, 0302 clinical medicine, 3123 Gynaecology and paediatrics, Child death, Infant Mortality, Epidemiology, Global health, Middle income country, Nacimiento vivo, 030212 general & internal medicine, 10. No inequality, Child, POPULATION, Developing world, education.field_of_study, Public health, Multidisciplinary, Geography, Mortality rate, wa_900, 1. No poverty, SUCCESS, Pediatrik, A900 Others in Medicine and Dentistry, 3142 Public health care science, environmental and occupational health, 3. Good health, Child Mortality, Death children, VACCINATION, HEALTH, ws_100, INTERVENTIONS, AFRICA, medicine.medical_specialty, United Nations, General Science & Technology, 030231 tropical medicine, Population, Developing country, Article, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], ITC-HYBRID, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Social Justice, Recién nacido, Neonatal deaths, medicine, SYSTEMATIC ANALYSIS, Organizational Objectives, Humans, education, Developing Countries, business.industry, Infant, Newborn, Infant, CIVIL REGISTRATION, Paediatrics, Child survival, Newborn, PREVENTION, Infant mortality, wa_320, ws_200, Child mortality, Socioeconomic Factors, ITC-ISI-JOURNAL-ARTICLE, Human medicine, Paediatrics, Public health, Developing world, business, Demography
Abstract: Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000–2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations., A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.
Published: 2019

15. Evaluation of anti-Toxoplasma effects of solid lipid nanoparticles carrying Cinnamon zeylanicum and Moringa oleifera oil extracts.

Author: Mottaghi M, Karami P, Hesari Z, Nemati S, Mohammad Rahimi H, and Mirjalali H
Subjects: Animals, Chlorocebus aethiops, Vero Cells, Plant Oils pharmacology, Plant Oils chemistry, Antiprotozoal Agents pharmacology, Cell Survival drug effects, Liposomes, Moringa oleifera chemistry, Nanoparticles chemistry, Toxoplasma drug effects, Plant Extracts pharmacology, Plant Extracts chemistry, Cinnamomum zeylanicum chemistry
Abstract: Background: The fabrication of anti-Toxoplasma drugs with less side effects and desirable efficacy is one of the important research goals facing with toxoplasmosis. This study aimed to determine the anti-Toxoplasma effects of Cinnamon zeylanicum (CZ), Moringa oleifera (MO) oil encapsulated into solid lipid nanoparticles (SLNs)., Methods: Vero cells were cultured with serial concentrations (1 mg/mL to 100 µg/mL) of CZ-SLNs and MO-SLNs in DMEM culture medium. The morphological, physical, and chemical features of nanoparticles were calculated. The cell viability assays and anti-T. gondii effects of CZ-SLNs and MO-SLNs were evaluated. The CC 50 and IC 50 indices of SLNs-enveloped extracts were calculated., Results: The particle sizes of MO-SLNs and CZ-SLNs were 411.5 and 365 nm, while PDI indices were 0.53 and 0.7, respectively. Transmission electron microscopy (TEM) showed that both MO-SLNs and CZ-SLNs were smoothed spherical nanoparticles with rounded edges. The cytotoxicity assay showed the CC 50 value of MO-SLNs at concentrations of ˃10 mg/mL. In addition, 60% of T. gondii-infected Vero cells remained alive at the concentrations ≤ 1 mg/ml, while the MO-SLNs killed at least 90% of T. gondii tachyzoites with an IC 50 > 1 µg/ml. The cytotoxicity of CZ-SLNs extract showed the CC 50 at the concentration 0.1 mg/mL. More than 50% of Vero cells, infected with T. gondii tachyzoites, survived at a concentration less than 0.1 mg/mL (IC 50 ˂ 0.1 mg/mL), while the CZ-SLNs killed at least 85% of T. gondii tachyzoites in all concentrations., Conclusion: The current results represented that the use of SLNs as a nano-carrier for M. oleifera and C. zeylanicum could kill T. gondii tachyzoites with low cytotoxicity, suggesting the effectiveness of these nano-emulsions along with the chemical agents in the treatment of Toxoplasma., (© 2024. The Author(s).)
Published: 2024
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16. Genetic Diversity and Phylogenetic Study of Leishmania Species in Iran by Multilocus Sequence Typing.

Author: Nemati S, Hajjaran H, Khamesipour A, Falahati Anbaran M, Mirjalali H, and Fazaeli A
Abstract: Background: Leishmaniasis is an important public health parasitic infection, which is endemic in many parts of the world, including Iran. We aimed to investigate genetic diversity and phylogenetic relationship among different Leishmania isolates using multi-locus sequence typing (MLST)., Methods: Totally, 41 isolates collected either from patients referred to Leishmaniasis Diagnostics and Treatment Center at Tehran University of Medical Sciences, Tehran, Iran or from animals during 2019-2021, were subjected to the study. They included L. major and L. tropica from human, L. infantum from canine, and L. turanica from rodents from different endemic foci of Iran analyzed using MLST including gp63, g6pdh, lack, nagt, and hsp70 genes., Results: A total of 5010 bps was analyzed from each isolate. The three targets, nagt , lack , and g6pdh , generated better topology comparing to the other genes. In the 44 isolates, 22 haplotypes (STs) were identified. Leishmania tropica contained the highest number of haplotypes (n=12) comparing to L. major (n=8), L. infantum (n=1) and L. turanica (n=1). All five genomic loci caused separation of Iranian Leishmania species at the species level, indicating conservation of these genes in the Leishmania parasite., Conclusion: The highest number of haplotypes belonged to L. tropica , indicating that the genetic diversity of this species is higher than that of L. major . It was further confirmed that the MLST is a suitable method to examine genetic variation of Leishmania parasites with respect to evolutionary and epidemiological studies., Competing Interests: Conflict of Interest The authors have no conflicts of interest concerning the work reported in this paper, (© 2024 Nemati et al. Published by Tehran University of Medical Sciences.)
Published: 2024
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17. Isolation and Molecular Identification of Vahlkampfiidae and Vermamoeba Vermiformis from Fresh Vegetables: A Neglected Source of Infections.

Author: Fatemi M, Niyyati M, Karamati SA, and Mirjalali H
Abstract: Background: Naegleria spp., Tetramitus spp., and Vermamoeba vermiformis are potential pathogenic free-living amoebae (FLA) causing diseases such as keratitis, meningoencephalitis, and lung infections. We aimed to investigate the presence of Vahlkampfiidae and V. vermiformis in raw vegetables commonly consumed in Iran., Methods: Totally, 70 samples of vegetables samples including watercress (22), leeks (12), parsley (10), basil (13) and mint (13) were collected from municipal markets of Tehran, the capital of Iran during June to October 2021. After washing vegetables, samples were cultivated onto 2% non-nutrient agar (NNA) medium. After morphological confirmations, DNA was extracted and identical fragments of the FLA were amplified and sequenced., Results: Out of 70 cultured samples, 11 samples (15.71 %) were morphologically positive, of which four and seven were V. vermiformis and Vahlkampfiidae isolates, respectively. According to the PCR/sequencing results two, one, one, and one strains belonged to N. australiensis , N. americana , Vahlkampfia sp., V. inornata, and T. aberdonicus, respectively. All Vermamoeba genus were characterized as V. vermiformis ., Conclusion: The results of current study revealed the contamination of fresh raw vegetables with Vahlkampfiidae and V. vermiformis. In addition, to our knowledge this is the first report of T. aberdonicus in raw vegetables. Our findings highlight the public health importance of vegetables in transmission of FLA, as well as the potential role of FLA in transmission of potential pathogenic microorganisms via consuming of fresh raw vegetables., Competing Interests: Conflict of interest The authors declare that they have no conflict of interest, (© 2024 Fatemi et al. Published by Tehran University of Medical Sciences.)
Published: 2024
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18. Design and evaluation of loop-mediated isothermal amplification for rapid detection of Enterocytozoon bieneusi .

Author: Mahdavi F, Mirjalali H, Niyyati M, Seyyed Tabaei SJ, Shamloo A, and Asadzadeh Aghdaei H
Abstract: Enterocytozoon bieneusi is one of the most prevalent microsporidia species, responsible for more than 90% of human and animal microsporidiosis. Microsporidia species, particularly E. bieneusi, are frequently reported from waterborne and foodborne outbreaks. Therefore, early detection is crucial in clinics and outbreak investigations. This study aimed to design a loop-mediated isothermal amplification (LAMP) for rapid detection of E. bieneusi. Total DNA was extracted from 30 E. bieneusi -positive samples, which had been confirmed with nested PCR. LAMP primers were designed based on the identical fragment of small subunit ribosomal RNA ( SSU rRNA ) gene. LAMP reactions were performed at 63 °C for 60 min. The sensitivity and specificity of the assay were analyzed and the results of amplification were compared to real-time PCR. Our results showed that the LAMP assay successfully amplified 25/30 (83.3%) samples. The specificity results indicated no false positive with other microorganisms. Furthermore, the LAMP method exhibited a sensitivity (limit of detection, LoD) as low as 34 ag/μL of total DNA. Compared to the LAMP assay, real-time PCR was able to detect all 30 nested PCR-positive samples. Our findings showed that the LAMP assay was able to detect 83.3% of E. bieneusi- positive samples. Although the current assay was not able to detect all nested PCR-positive samples, the lack of need for specific instruments, rapid processes, and high specificity makes LAMP assay a suitable tool for screening., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)
Published: 2024
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19. Anti- Toxoplasma gondii activity of rose hip oil-solid lipid nanoparticles.

Author: Mohammad Rahimi H, Hesari Z, Mirsamadi ES, Nemati S, and Mirjalali H
Abstract: Toxoplasma gondii is a highly prevalent pathogen, reported from almost all geographical regions of the world. Current anti- T. gondii drugs are not effective enough in immunocompromised patients, encephalitis, chorioretinitis, and congenital toxoplasmosis. Therefore, the prescription of these drugs has been limited. Rose hip oil (RhO) is a natural plant compound, which shows antibacterial, anticancer, and anti-inflammatory activities. In the current study, the anti- T. gondii and cell toxicity effects of solid lipid nanoparticles (SLNs) loaded by RhO (RhO-SLNs) were evaluated. Emulsification sonicated-homogenization method was used to prepare SLNs. RhO-SLNs were characterized, and their anti- T. gondii and cell toxicity effects were evaluated using in vitro analyses. The particle size and the zeta potential of the nanoparticles were 152.09 nm and -15.3 mV nm, respectively. The entrapment efficiency percentage was 79.1%. In the present study, the inhibitory concentration (IC) 50 against T. gondii was >1 μg/mL ( p -value <.0001). The cell toxicity assay showed cytotoxicity concentration (CC) 50 >10 mg/mL ( p -value = .017). In addition, at least 75% of T. gondii -infected Vero cells remained alive at concentrations >10 mg/mL. The concentration of 1 mg/mL showed highest anti- Toxoplasma activity and lowest cell toxicity against the Vero cell. Our findings suggest that carrying natural plant compounds with SLNs could be considered an effective option for treatment strategies against T. gondii infections., Competing Interests: The authors declare that they have no conflict of interest., (© 2024 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.)
Published: 2024
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20. Development of solid lipid nanoparticles-loaded drugs in parasitic diseases.

Author: Nemati S, Mottaghi M, Karami P, and Mirjalali H
Abstract: Parasites cause illnesses with broad spectrum of symptoms from mild to severe, and are responsible for a significant number of outbreaks in the world. Current anti-parasitic drugs are toxic and have significant side effects. Nano-carriers are believed to obviate the limitations of conventional drugs via decreasing side effects and increasing target delivery and drug permeability with a controlled prolonged release of a drug. Solid lipid nanoparticles (SLNs) are lipid nanoparticles (LNPs), which have frequently been practiced. Suitable release rate, stability, and target delivery make SLNs a good alternative for colloidal carriers. SLNs are supposed to have great potential to deliver natural products with anti-parasitic properties. Nanoparticles have employed to improve stability and capacity loading of SLNs, during recent years. This review describes development of SLNs, the methods of preparation, characterization, and loaded drugs into SLNs in parasitic diseases. In addition, we summarize recent development in anti-parasitic SLNs-loaded drugs., (© 2024. The Author(s).)
Published: 2024
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21. Prevalence of intestinal parasitic infections in patients with diabetes: a systematic review and meta-analysis.

Author: Taghipour A, Javanmard E, Rahimi HM, Abdoli A, Matin S, Haghbin M, Olfatifar M, Mirjalali H, and Zali MR
Subjects: Humans, Prevalence, Cross-Sectional Studies, Feces parasitology, Cryptosporidiosis, Cryptosporidium, Intestinal Diseases, Parasitic epidemiology, Intestinal Diseases, Parasitic parasitology, Diabetes Mellitus epidemiology
Abstract: Patients with diabetes are at an increased risk of intestinal parasitic infections (IPIs). We evaluated the pooled prevalence and OR of IPIs in patients with diabetes through a systematic review and meta-analysis. A systematic search was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol for studies reporting IPIs in patients with diabetes through 1 August 2022. The collected data were analyzed using comprehensive meta-analysis software version 2. Thirteen case-control studies and nine cross-sectional studies were included in this study. The overall prevalence of IPIs in patients with diabetes was calculated to be 24.4% (95% CI 18.8 to 31%). Considering the case-control design, the prevalence of IPIs in case (25.7%; 95% CI 18.4 to 34.5%) was higher than controls (15.5%; 95% CI 8.4 to 26.9%) and a significant correlation was observed (OR, 1.80; 95% CI 1.08 to 2.97%). Moreover, a significant correlation was seen in the prevalence of Cryptosporidium spp. (OR, 3.30%; 95% CI 1.86 to 5.86%), Blastocystis sp. (OR, 1.57%; 95% CI 1.11 to 2.22%) and hookworm (OR, 6.09%; 95% CI 1.11 to 33.41%) in the cases group. The present results revealed a higher prevalence of IPIs in patients with diabetes than in controls. Therefore, the results of this study suggest a proper health education program to preventing measures for the acquisition of IPIs in patients with diabetes., (© The Author(s) 2023. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.)
Published: 2024
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22. Current status of intestinal parasitic infections and associated risk factors in rural population of Guilan province, northern Iran: trichostrongyliasis is the most prevalent helminthic infection.

Author: Ashrafi K, Shekari M, Sharifdini M, Mahmoudi MR, Atrkar Roshan Z, Rahmati B, Rezvani SM, Omidvar A, and Mirjalali H
Abstract: Aim: This study aimed to determine the distribution of enteric parasitic infections and related risk factors among rural communities of Guilan province, Northern Iran, and to compare the results with the situation in the past., Background: Intestinal parasitic infections are still considered as a major public health concern, particularly in human communities with poor economy and sanitation., Methods: This cross-sectional study was performed in rural areas of Masal and Shanderman district from February to December 2020. A total of 917 stool samples were collected and examined for presence of intestinal helminthes and protozoa using direct, formalin-ether and Kato-Katz techniques., Results: A total of 156 (17%) out of 917 examined individuals were infected with intestinal parasites. The overall prevalence of protozoa, helminths and mixed infections were 11.8% (108/917), 4.5% (41/917) and 0.8% (7/917), respectively. Blastocystis was the most prevalent intestinal protozoa (9.6%) followed by Giardia lamblia (1.9%), Endolimax nana (1.1%), E. coli (0.8%) and Entamoeba hartmani (0.1%). The highest prevalence of intestinal helminths belonged to Trichostongylus spp. (3.5%) and Strongyloides stercoralis (1.3%). Statistical analysis showed significant association between giardiasis and sex (P<0.03). On the other hand, prevalence of enteric helminths was influenced by close contact with livestock, keeping herbivorous animals at home, job, education, and consumption of uncooked vegetables (P<0.05)., Conclusion: The findings indicate a decreasing trend in the prevalence of intestinal parasitic infections in Guilan province in comparison to the past few decades. Hookworm infections, which was very prevalent in the area, are now rare, while trichostrongylosis showed a high prevalence in rural residents of the study area., Competing Interests: The authors report no conflicts of interest in this work., (© 2024, Gastroenterology and Hepatology From Bed to Bench (GHFBB).)
Published: 2024
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23. The effects of Leishmania RNA virus 2 (LRV2) on the virulence factors of L. major and pro-inflammatory biomarkers: an in vitro study on human monocyte cell line (THP-1).

Author: Mirabedini Z, Mirjalali H, Kazemirad E, Khamesipour A, Samimirad K, Koosha M, Saberi R, Rahimi HM, Mohebali M, and Hajjaran H
Subjects: Humans, NLR Family, Pyrin Domain-Containing 3 Protein, Monocytes, Interleukin-18, Biomarkers, Leishmania, Leishmaniavirus genetics, Leishmaniasis, Cutaneous, RNA Viruses genetics
Abstract: Background: Cutaneous Leishmaniasis (CL) is a parasitic disease with diverse outcomes. Clinical diversity is influenced by various factors such as Leishmania species and host genetic background. The role of Leishmania RNA virus (LRV), as an endosymbiont, is suggested to not only affect the pathogenesis of Leishmania, but also impact host immune responses. This study aimed to investigate the influence of LRV2 on the expression of a number of virulence factors (VFs) of Leishmania and pro-inflammatory biomarkers., Materials and Methods: Sample were obtained from CL patients from Golestan province. Leishmania species were identified by PCR (LIN 4, 17), and the presence of LRV2 was checked using the semi-nested PCR (RdRp gene). Human monocyte cell line (THP-1) was treated with three isolates of L. major with LRV2 and one isolate of L. major without LRV2. The treatments with four isolates were administered for the time points: zero, 12, 24, 36, and 48 h after co-infection. The expression levels of Leishmania VFs genes including GP63, HSP83, and MPI, as well as pro-inflammatory biomarkers genes including NLRP3, IL18, and IL1β, were measured using quantitative real-time PCR., Results: The expression of GP63, HSP83, and MPI revealed up-regulation in LRV2 + isolates compared to LRV2- isolates. The expression of the pro-inflammatory biomarkers including NLRP3, IL1β, and IL18 genes in LRV2- were higher than LRV2 + isolates., Conclusion: This finding suggests that LRV2 + may have a probable effect on the Leishmania VFs and pro-inflammatory biomarkers in the human macrophage model., (© 2023. The Author(s).)
Published: 2023
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24. Profiling of the fecal microbiota and circulating microRNA-16 in IBS subjects with Blastocystis infection : a case-control study.

Author: Olyaiee A, Yadegar A, Mirsamadi ES, Sadeghi A, and Mirjalali H
Subjects: Humans, Case-Control Studies, Irritable Bowel Syndrome, Blastocystis Infections microbiology, Circulating MicroRNA, Blastocystis, Microbiota, MicroRNAs
Abstract: Irritable bowel syndrome (IBS) is a prevalent gastrointestinal (GI) tract disorder. Although the main reason for IBS is not clear, the interaction between intestinal microorganisms and the gut barrier seems to play an important role in pathogenesis of IBS. The current study aimed to investigate the effect of Blastocystis on the gut microbiota profile and the circulation levels of microRNA (mir)-16 of IBS patients compared to healthy subjects. Stool and blood samples were collected from 80 participants including 40 samples from each IBS and healthy group. Upon DNA extraction from stool samples, barcoding region and quantitative real-time PCR were analyzed to investigate Blastocystis and the microbiota profile, respectively. RNA was extracted from serum samples of included subjects and the expression of mir-16 was evaluated using stem-loop protocol and qreal-time PCR. Significant changes between IBS patients and healthy controls was observed in Firmicutes, Actinobacteria, Faecalibacterium, and Alistipes. In IBS patients, the relative abundance of Bifidobacteria was directly correlated with the presence of Blastocystis, while Alistipes was decreased with Blastocystis. Lactobacillus was significantly increased in Blastocystis carriers. In healthy subjects, the relative abundance of Bifidobacteria was decreased, but Alistipes was increased in Blastocystis carriers. The changes in the Firmicutes/Bacteroidetes ratio was not significant in different groups. The relative expression of mir-16 in Blastocystis-negative IBS patients and healthy carriers was significantly overexpressed compared to control group. The presence of Blastocystis, decreased the relative expression of mir-16 in IBS patients compared to Blastocystis-negative IBS patients. The present study revealed that Blastocystis has the ability to change the abundance of some phyla/genera of bacteria in IBS and healthy subjects. Moreover, Blastocystis seems to modulate the relative expression of microRNAs to control the gut atmosphere, apply its pathogenicity, and provide a favor niche for its colonization., (© 2023. The Author(s).)
Published: 2023
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25. Long non-coding RNAs ANRIL, THRIL, and NEAT1 as potential circulating biomarkers of SARS-CoV-2 infection and disease severity.

Author: Rahni Z, Hosseini SM, Shahrokh S, Saeedi Niasar M, Shoraka S, Mirjalali H, Nazemalhosseini-Mojarad E, Rostami-Nejad M, Malekpour H, Zali MR, and Mohebbi SR
Subjects: Adult, Aged, Female, Humans, Male, Middle Aged, Case-Control Studies, Severity of Illness Index, Biomarkers blood, COVID-19 blood, COVID-19 diagnosis, COVID-19 virology, RNA, Long Noncoding blood, RNA, Long Noncoding genetics, SARS-CoV-2 genetics
Abstract: The current outbreak of coronavirus disease 2019 (COVID-19) is a global emergency, as its rapid spread and high mortality rate, which poses a significant threat to public health. Innate immunity plays a crucial role in the primary defense against infections, and recent studies have highlighted the pivotal regulatory function of long non-coding RNAs (lncRNAs) in innate immune responses. This study aims to assess the circulating levels of lncRNAs namely ANRIL, THRIL, NEAT1, and MALAT1 in the blood of moderate and severe SARS-CoV-2 infected patients, in comparison to healthy individuals. Additionally, it aims to explore the potential of these lncRNAs as biomarkers for determining the severity of the disease. The blood samples were collected from a total of 38 moderate and 25 severe COVID-19 patients, along with 30 healthy controls. The total RNA was extracted and qPCR was performed to evaluate the blood levels of the lncRNAs. The results indicate significantly higher expression levels of lncRNAs ANRIL and THRIL in severe patients when compared to moderate patients (P value = 0.0307, P value = 0.0059, respectively). Moreover, the expression levels of lncRNAs ANRIL and THRIL were significantly up-regulated in both moderate and severe patients in comparison to the control group (P value < 0.001, P value < 0.001, P value = 0.001, P value < 0.001, respectively). The expression levels of lncRNA NEAT1 were found to be significantly higher in both moderate and severe COVID-19 patients compared to the healthy group (P value < 0.001, P value < 0.001, respectively), and there was no significant difference in the expression levels of NEAT1 between moderate and severe patients (P value = 0.6979). The expression levels of MALAT1 in moderate and severe patients did not exhibit a significant difference compared to the control group (P value = 0.677, P value = 0.764, respectively). Furthermore, the discriminative power of ANRIL and THRIL was significantly higher in the severe patient group than the moderate group (Area under curve (AUC) = 0.6879; P-value = 0.0122, AUC = 0.6947; P-value = 0.0093, respectively). In conclusion, the expression levels of the lncRNAs ANRIL and THRIL are correlated with the severity of COVID-19 and can be regarded as circulating biomarkers for disease progression., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier B.V.)
Published: 2023
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26. Characterisation of extracellular vesicles isolated from hydatid cyst fluid and evaluation of immunomodulatory effects on human monocytes.

Author: Khosravi M, Mohammad Rahimi H, Nazari A, Baghaei K, Asadzadeh Aghdaei H, Shahrokh S, Sharifdini M, Torrecilhas AC, Mehryab F, Mirjalali H, Shekari F, and Zali MR
Subjects: Humans, Animals, Sheep, Monocytes metabolism, Interleukin-10 metabolism, Cytokines genetics, Cytokines metabolism, Immunity, Echinococcosis metabolism, Extracellular Vesicles metabolism
Abstract: Hydatidosis is a disease caused by the larval stage of Echinococcus granulosus, which involves several organs of intermediate hosts. Evidence suggests a communication between hydatid cyst (HC) and hosts via extracellular vesicles. However, a little is known about the communication between EVs derived from HC fluid (HCF) and host cells. In the current study, EVs were isolated using differential centrifugation from sheep HCF and characterized by western blot, electron microscope and size distribution analysis. The uptake of EVs by human monocyte cell line (THP-1) was evaluated. The effects of EVs on the expression levels of pro- and anti-inflammatory cytokines were investigated using quantitative real-time PCR (RT-PCR), 3 and 24 h after incubation. Moreover, the cytokine level of IL-10 was evaluated in supernatant of THP-1 cell line at 3 and 24 h. EVs were successfully isolated and showed spherical shape with size distribution at 130.6 nm. After 3 h, the expression levels of pro-inflammatory cytokine genes (IL1Β, IL15 and IL8) were upregulated, while after 24 h, the expression levels of pro-inflammatory cytokines were decreased and IL13 gene expression showed upregulation. A statistically significant increase was seen in the levels of IL-10 after 24 h. The main mechanism of the communication between EVs derived from HCF and their host remains unclear; however, time-dependent anti-inflammatory effects in our study suggest that HC may modulate the immune responses via EVs., (© 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
Published: 2023
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27. Editorial: Genomic and evolutionary analysis of microsporidian parasites.

Author: Huang Q, Mirjalali H, and Zhou Z
Abstract: Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Published: 2023
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28. Iranian Hydatid Disease Registry: Establishment and Implementation of a Neglected Tropical Disease Registry.

Author: Nasibi S, Mojarrab S, Lashkarizadeh MR, Shafiei M, Saedi Dezaki E, Mahmoudvand H, Alizadeh A, Mohammadzadeh A, Adnani Sadati SJ, Mirbadie SR, Keighobadi M, Gholami S, Raeghi S, Abbasi M, Mohtasham F, Ravari MS, Dabirzadeh M, Mosavi Anari SA, Mirjalali H, Aliakbarian M, Abbasifard M, and Fasihi Harandi M
Subjects: Humans, Iran epidemiology, Public Health, Registries, Neglected Diseases epidemiology, Echinococcosis epidemiology, Echinococcosis parasitology
Abstract: Background: Cystic echinococcosis (CE) or hydatid disease is a global public health concern which imposes considerable economic costs on the communities in endemic regions. CE surveillance data are not adequately reliable. The present study reports the development and outcomes of a CE registry in Iran., Methods: Hydatid Registry (HydatidReg) was initially established as a single-center registry in 2014 after the ethical approval of KMU. Following a call from MoHME to promote registry of different diseases and health outcomes, a call for participation was announced and all the Iranian Universities of Medical Sciences were requested to contribute to the registry. Subsequently, a nation-wide registry of hydatid disease was established in 2016. With a global perspective, HydatidReg joined the European Register of Cystic Echinococcosis (ERCE). A data collection form based on minimum dataset was designed and standard operating procedures (SOPs) were prepared to ensure standardized patient enrolment in the registry. A biobank system with two-dimensional barcoding was established along with HydatidReg for management and organization of biological specimens., Results: As of March 2021, a total of 690 patients were enrolled in the registry. HydatidReg registered 362 (17.3%) out of the total 2097 patients enrolled in ERCE. Quality control (QC) of the data demonstrated 91.2% completeness and 80% timeliness. In the biobank, 322 biological specimens from 184 CE patients have been deposited including 70 blood, 96 sera and 156 parasite materials., Conclusion: High-quality data in the HydatidReg registry provided opportunities for health professionals to improve quality of care and organize meaningful research., (© 2023 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.)
Published: 2023
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29. Gastrointestinal Parasites of Domestic Mammalian Hosts in Southeastern Iran.

Author: Hatam-Nahavandi K, Carmena D, Rezaeian M, Mirjalali H, Rahimi HM, Badri M, Vafae Eslahi A, Shahrivar FF, Rodrigues Oliveira SM, Pereira ML, and Ahmadpour E
Abstract: Gastrointestinal parasites (GIP) are a major cause of disease and production loss in livestock. Some have zoonotic potential, so production animals can be a source of human infections. We describe the prevalence of GIP in domestic mammals in Southeastern Iran. Fresh fecal samples ( n = 200) collected from cattle ( n = 88), sheep ( n = 50), goats ( n = 23), camels ( n = 30), donkeys ( n = 5), horse ( n = 1), and dogs ( n = 3) were subjected to conventional coprological examination for the detection of protozoan (oo)cysts and helminth ova. Overall, 83% (166/200) of the samples were positive for one or more GIP. Helminths were found in dogs, donkeys, sheep (42%), camels (37%), goats (30%), and cattle (19%), but not in the horse. Protozoa were found in cattle (82%), goats (78%), sheep (60%), and camels (13%), but not in donkeys, dogs, or the horse. Lambs were 3.5 times more likely to be infected by protozoa than sheep (OR = 3.5, 95% CI: 1.05-11.66), whereas sheep were at higher odds of being infected by helminths than lambs (OR = 4.09, 95% CI: 1.06-16.59). This is the first study assessing the prevalence of GIP in domestic mammals in Southeastern Iran.
Published: 2023
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30. Multigene typing of Giardia Duodenalis isolated from tuberculosis and non-tuberculosis subjects.

Author: Mohammad Rahimi H, Javanmard E, Taghipour A, Haghighi A, and Mirjalali H
Subjects: Humans, Phylogeny, Multilocus Sequence Typing, Giardia, Genotype, Feces, Triose-Phosphate Isomerase genetics, Glutamate Dehydrogenase genetics, Databases, Nucleic Acid, Giardia lamblia, Giardiasis epidemiology
Abstract: Giardia duodenalis is a cryptic protozoan, which has eight assemblages (A-H). Assemblages A and B are the main genotypes reported from humans with probable anthroponotic and zoonotic transmission. The current study aimed to characterize G. duodenalis assemblages in tuberculosis (TB) patients and healthy subjects using multilocus genotyping (MLG). Thirty Giardia-positive stool samples, which were obtained from TB patients and healthy subjects were included in the study. After total DNA extraction, three β-giardin (bg), triosephosphate isomerase (tpi), glutamate dehydrogenase (gdh) genes were amplified and sequenced. Obtained sequences were compared to the GenBank database to characterize assemblages. Phylogenetic analysis using Maximum Likelihood (ML) and Tamura 3-parameter was performed for each gene. From 30 Giardia-positive subjects, 17 (57%) and 13 (43%) were from healthy and TB-infected subjects, respectively. There was no significant co-existence of Giardia and tuberculosis (P-value = 0.051). In addition, 14 (46.7%) and 16 (53.3%) of Giardia isolates were from asymptomatic and symptomatic subjects, respectively. PCR amplification was successful in 25 single samples (83.3%) consisted of 20 for tpi, 15 for bg, and 13 for gdh genes. Accordingly, 13/25 (52%) and 8/25 (32%) belonged to assemblage A and assemblages B, respectively, whereas 4/25 (16%) were either assemblage A or B with different genes at the same time. Significant correlation between assemblages and TB, age, and symptoms was not seen. The phylogenetic analyses represented no separation based on TB and gastrointestinal symptoms. Assemblage A was the predominant genotype in samples. The high frequency of assemblage AII indicated importance of anthroponotic transmission of Giardia in both healthy and TB patients. In addition, considering the exclusive reports of sub-assemblage AIII in wild ruminants, the presence of AIII in the current study have to be carefully interpreted. The inconsistency between the assemblage results of either bg or gdh loci with tpi gene signifies the insufficiency of single gene analysis and the necessity for MLG in molecular epidemiology of G. duodenalis., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Mohammad Rahimi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Published: 2023
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31. Evaluation of the mTORC activity in the presence of Toxoplasma gondii and azathioprine in human monocyte cell line.

Author: Nemati S, Mohammad Rahimi H, Meyfour A, Pazoki H, Asadzadeh Aghdaei H, Shahrokh S, and Mirjalali H
Subjects: Humans, Azathioprine pharmacology, Monocytes, Cell Line, Toxoplasma genetics, Inflammatory Bowel Diseases
Abstract: Background: Autophagy is an important part of pathogenesis of IBD. Thiopurines such as azathioprine (AZA) are approved drugs for clinical practices in IBD patients. Besides, as an escape strategy, Toxoplasma gondii can use the mTORC1 complex to inactivate autophagy., Methods: In this study, we investigated whether T. gondii tachyzoites may modulate autophagy and interfere the effects of azathioprine in IBD treatment. PMA-activated human monocyte cell line (THP-1) was infected with fresh T. gondii RH tachyzoites. After 5 h of infection, the cells were treated with AZA for 6 h. The expression of atg5, atg7, atg12, lc3b, and β-actin (BACT) genes was evaluated using quantitative real-time PCR. To analyze the phosphorylation of ribosomal protein S6 (rpS6), western blot using specific primary antibodies was performed., Results: The results of real-time PCR revealed that AZA, T. gondii tachyzoites, and a combination of AZA and T. gondii tachyzoites upregulated atg5 gene for 4.297-fold (P-value = 0.014), 2.49-fold (P-value = 0.006), and 4.76-fold (P-value = 0.001), respectively. The atg7 gene showed significant upregulation (2.272-fold; P-value = 0.014) and (1.51-fold; P-value = 0.020) in AZA and AZA / T. gondii, respectively. The expression of atg12 gene was significantly downregulated in AZA and T. gondii tachyzoites for (8.85-fold; P-value = 0.004) and (2.005-fold; P-value = 0.038), respectively, but upregulated in T. gondii/AZA (1.52-fold; P-value = 0.037). In addition, the lc3b gene was only significantly changed in AZA / T. gondii (3.028-fold; P-value = 0.001). Western blot analysis showed that T. gondii tachyzoites significantly phosphorylated rpS6, and tachyzoites did not interfere the effects of AZA to phosphorylate the rpS6., Conclusion: Taken together, although AZA and T. gondii similarly affects the expression levels of atg5, atg7, and atg12, but T. gondii does not seem to modulate the effects of AZA via mTORC functions., (© 2023. The Author(s).)
Published: 2023
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32. Toward waterborne protozoa detection using sensing technologies.

Author: Nemati S, Shalileh F, Mirjalali H, and Omidfar K
Abstract: Drought and limited sufficient water resources will be the main challenges for humankind during the coming years. The lack of water resources for washing, bathing, and drinking increases the use of contaminated water and the risk of waterborne diseases. A considerable number of waterborne outbreaks are due to protozoan parasites that may remain active/alive in harsh environmental conditions. Therefore, a regular monitoring program of water resources using sensitive techniques is needed to decrease the risk of waterborne outbreaks. Wellorganized point-of-care (POC) systems with enough sensitivity and specificity is the holy grail of research for monitoring platforms. In this review, we comprehensively gathered and discussed rapid, selective, and easy-to-use biosensor and nanobiosensor technologies, developed for the early detection of common waterborne protozoa., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Nemati, Shalileh, Mirjalali and Omidfar.)
Published: 2023
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33. The modulation of macrophage subsets in celiac disease pathogenesis.

Author: Molaaghaee-Rouzbahani S, Asri N, Jahani-Sherafat S, Amani D, Masotti A, Baghaei K, Yadegar A, Mirjalali H, and Rostami-Nejad M
Subjects: Humans, Gliadin, Macrophages, Adaptive Immunity, Inflammation, Celiac Disease, Autoimmune Diseases
Abstract: Background: So far, limited studies have focused on the role of Macrophages (MQs) in the development or progression of celiac disease (CD). Researchers believe that increasing knowledge about the function of MQs in inflammatory disorders plays a critical role in finding a new treatment for these kinds of diseases., Main Body: CD is a permanent autoimmune intestinal disorder triggered by gluten exposure in predisposed individuals. This disorder happens due to the loss of intestinal epithelial barrier integrity characterized by dysregulated innate and adaptive immune responses. MQs are known as key players of the innate immune system that link innate and adaptive immunity. MQs of human intestinal lamina propria participate in maintaining tissue homeostasis, and also intestinal inflammation development. Previous studies suggested that gliadin triggers a proinflammatory phenotype (M1 MQ) in human primary MQs. Moreover, M2-related immunosuppressive mediators are also present in CD. In fact, CD patients present an impaired transition from pro-inflammatory to anti-inflammatory responses due to inappropriate responses to gliadin peptides., Conclusion: The M1/M2 MQs polarization balancing regulators can be considered novel therapeutic targets for celiac disease., (© 2022 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.)
Published: 2022
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34. Exosomes secreted by Blastocystis subtypes affect the expression of proinflammatory and anti-inflammatory cytokines (TNFα, IL-6, IL-10, IL-4).

Author: Norouzi M, Pirestani M, Arefian E, Dalimi A, Sadraei J, and Mirjalali H
Abstract: Background: Blastocystis sp. is a common intestinal parasite, possibly responsible for diarrhea, vomiting and nausea, abdominal pain, and irritable bowel syndrome. However, many studies focused on this issue due to the uncertainty of its pathogenic potential. The extracellular vesicles (EVs) are significant mediators for cellular communication, carrying biological molecules such as proteins, lipids, and nucleic acids. Compared with other parasites, little is known about the Blastocystis EVs. Hence the present investigation was done., Methods: The Blastocystis parasites were cultured in the DMEM medium, and a 550-585 bp fragment was amplified using PCR, and sequencing was done. A commercial kit was used for exosome extraction and dynamic light scattering (DLS), flow cytometry (CD63, CD81 markers), and electron microscopy tests to determine their morphology. The human leukemia monocytic cell line (THP-1) was exposed to Blastocystis EVs. Next, the expression of proinflammatory and anti-inflammatory cytokines, including IL-4, IL-6, IL-10, and tumor necrosis factor-alpha (TNF-α), were measured using quantitative PCR., Results: Exosomes were extracted from ST1-3 Blastocystis sp. According to the DLS assay, the size of the exosomes was in the range of 30-100 nm. Electron microscopy images and CD63 and CD81 markers also confirmed the exosome's size, structure, and morphology. According to real-time PCR results, ST1-derived exosomes caused IL-6 and TNF-α upregulation and IL-10 and IL-4 downregulation, ST2- and ST3-derived exosomes downregulated IL-10, and ST3-derived exosomes caused IL-6 upregulation. There is a statistically significant difference ( P ≤ 0.05)., Conclusion: To our knowledge, this is the first report of the release of exosome-like vesicles by the human parasite, Blastocystis , and the provided information demonstrates the role of this parasite, particularly ST1 on proinflammatory and anti-inflammatory cytokines and navigating the host response., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Norouzi, Pirestani, Arefian, Dalimi, Sadraei and Mirjalali.)
Published: 2022
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35. Molecular analysis of internal transcribed spacer 2 of Dicrocoelium dendriticum isolated from cattle, sheep, and goat in Iran.

Author: Javanmard E, Mohammad Rahimi H, Nemati S, Soleimani Jevinani S, and Mirjalali H
Subjects: Animals, Cattle, DNA, Helminth genetics, Goats genetics, Iran, Phylogeny, Sheep genetics, Cattle Diseases, Dicrocoelium genetics, Goat Diseases, Sheep Diseases
Abstract: Background: Dicrocoelium dendriticum is a broadly distributed zoonotic helminth, which is mainly reported from domesticated and wild ruminants. There is little data covering the molecular features of this trematode; therefore, current study aimed to molecularly analyze D. dendriticum in livestock., Methods: Totally, 23 samples of D. dendriticum were collected from cattle, sheep, and goat from Ilam, Lorestan, and Khuzestan, three west and south-west provinces of Iran from February to August 2018. After genomic DNA extraction, the internal transcribed spacer (ITS) 2 fragment was amplified and sequenced in samples. To investigate genetic variations through the ITS 2 fragment of obtained D. dendriticum, phylogenetic tree and network analysis were employed., Results: All 23 samples were successfully amplified and sequenced. Phylogenetic tree showed that our samples were clearly grouped in a clade together with reference sequences. There was no grouping based on either geographical regions or hosts. Network analysis confirmed the phylogenetic findings and showed the presence of nine distinct haplotypes, while our samples together most of sequences, which were previously submitted to the GenBank, were grouped in the Hap1., Conclusions: Our findings indicated that although ITS 2 fragment discriminate D. dendriticum, this fragment is not suitable to study intra-species genetic variations. Therefore, exploring and describing new genetic markers could be more appropriate to provide new data about the genetic distribution of this trematode., (© 2022. The Author(s).)
Published: 2022
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36. Gut Microbiota Shifting in Irritable Bowel Syndrome: The Mysterious Role of Blastocystis sp.

Author: Olyaiee A, Sadeghi A, Yadegar A, Mirsamadi ES, and Mirjalali H
Abstract: Irritable bowel syndrome (IBS) is a chronic disorder, which its causative agent is not completely clear; however, the interaction between microorganisms and gastrointestinal (GI) epithelial cells plays a critical role in the development of IBS and presenting symptoms. During recent decades, many studies have highlighted the high prevalence of Blastocystis sp. in patients with IBS and suggested a probable role for this protist in this disease. Recent studies have documented changes in the gut microbiota composition in patients with IBS regarding the presence of Blastocystis sp., but it is not clear that either disturbance of the gut during GI disorders is a favorable condition for Blastocystis sp. colonization or the presence of this protist may lead to alteration in the gut microbiota in IBS patients. In this review, we comprehensively gather and discuss scientific findings covering the role of Blastocystis sp. in IBS via gut microbiota shifting., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Olyaiee, Sadeghi, Yadegar, Mirsamadi and Mirjalali.)
Published: 2022
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37. Formulation of Neem oil-loaded solid lipid nanoparticles and evaluation of its anti-Toxoplasma activity.

Author: Nemati S, Mohammad Rahimi H, Hesari Z, Sharifdini M, Jalilzadeh Aghdam N, Mirjalali H, and Zali MR
Subjects: Animals, Chlorocebus aethiops, Glycerides, Humans, Liposomes, Terpenes, Vero Cells, Nanoparticles, Toxoplasma
Abstract: Background: Toxoplasmosis is caused by an intracellular zoonotic protozoan, Toxoplasma gondii, which could be lethal in immunocompromised patients. This study aimed to synthesize Neem oil-loaded solid lipid nanoparticles (NeO-SLNs) and to evaluate the anti-Toxoplasma activity of this component., Methods: The NeO-SLNs were constructed using double emulsification method, and their shape and size distribution were evaluated using transmission electron microscope (TEM) and dynamic light scattering (DLS), respectively. An MTT assay was employed to evaluate the cell toxicity of the component. The anti-Toxoplasma activity of NeO-SLNs was investigated using vital (trypan-blue) staining. Anti-intracellular Toxoplasma activity of NeO-SLNs was evaluated in T. gondii-infected Vero cells., Results: The TEM analysis represented round shape NeO-SLNs with clear and stable margins. DLS analysis showed a mean particle size 337.6 nm for SLNs, and most of nanoparticles were in range 30 to 120 nm. The cell toxicity of NeO-SLNs was directly correlated with the concentration of the component (P-value = 0.0013). The concentration of NeO-SLNs, which was toxic for at least 50% of alive T. gondii (cytotoxic concentration (CC 50 )), was > 10 mg/mL. The ability of NeO-SLNs to kill Toxoplasma was concentration-dependent (P-value < 0.0001), and all concentrations killed at least 70% of alive tachyzoites. Furthermore, the viability of T. gondii- infected Vero cells was inversely correlated with NeO-SLNs concentrations (P-value = 0.0317), and in the concentration 100 μg/mL at least 75% of T. gondii- infected Vero cells remained alive., Conclusions: Overall, our findings demonstrated that the NeO-SLNs was able to kill T. gondii tachyzoites in concentration 100 μg/mL with a cell toxicity lower than 20%. Such results suggest that employing SLNs as carrier for NeO can effectively kill T. gondii tachyzoites with acceptable cell toxicity. Our findings also showed that SLNs capsulation of the NeO can lead to prolonged release of the extract, suggesting that NeO-SLNs could be also employed to clear cyst stages, which should be further investigated in animal models., (© 2022. The Author(s).)
Published: 2022
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38. Prevalence and molecular characterization of Dirofilaria immitis in road killed canids of northern Iran.

Author: Sharifdini M, Karimi M, Ashrafi K, Soleimani M, and Mirjalali H
Subjects: Animals, Dogs, Female, Iran epidemiology, Jackals, Male, Prevalence, RNA, Ribosomal, 18S genetics, Dirofilaria immitis genetics, Dirofilariasis epidemiology, Dog Diseases epidemiology
Abstract: Background: Dirofilaria immitis is a mosquito-borne filarial nematode, which infects primarily wild and domestic canids, causing cardiopulmonary dirofilariasis. The aim of the present study was to determine the prevalence and characterize molecular features of D. immitis in road killed canids, northern Iran., Methods: The carcasses of 53 road killed canids including 18 dogs (Canis familiaris), and 35 golden jackals (C. aureus) were necropsied in both Mazanderan and Guilan provinces, northern Iran. The molecular analyses were conducted based on the cytochrome oxidase (Cox) 1 and 18S ribosomal RNA (rRNA) genes., Results: The heartworm infection was found in 55.6% of dogs and 22.9% of jackals. Our study revealed significantly higher prevalence of D. immitis in dogs compared to jackals (P = 0.031). The prevalence of D. immitis was no statistically significant between males and females in both dogs and jackal (P > 0.05). Comparison of the Cox1 gene sequences with available data in the GenBank illustrated 100% similarity with D. immitis isolates from different hosts in European, Asian, and South American continents. Moreover, the 18S rRNA gene sequences showed 100% identity with dog isolates from Japan and French Guiana., Conclusions: This study confirms the high prevalence of D. immitis in dogs and jackals of northern Iran. Developing control programs to prevent transmission of the disease is necessary for dogs and humans in the study areas., (© 2022. The Author(s).)
Published: 2022
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39. Modulation of microRNAs and claudin-7 in Caco-2 cell line treated with Blastocystis sp., subtype 3 soluble total antigen.

Author: Mohammad Rahimi H, Yadegar A, Asadzadeh Aghdaei H, Mirjalali H, and Zali MR
Subjects: Caco-2 Cells, Claudins genetics, Humans, Interleukin-8 genetics, Occludin metabolism, Blastocystis genetics, MicroRNAs genetics
Abstract: Background: Blastocystis sp., is a eukaryote of the large intestine, which is reported from almost all countries. The pathogenesis of this protist is not clear. The current study aimed to analyze the effects of Blastocystis sp., ST3 soluble total antigen (B3STA) on the microRNAs (miRNAs) involved in the gut permeability and also pro-inflammatory cytokines, occludin, and claudin-7., Methods: Blastocystis sp., ST3 isolated from stool sample was purified, and its soluble total antigen was extracted using freeze and thawing. The Caco-2 cell line was treated with B3STA for 24 h and the expression levels of mir-16, mir-21, mir-29a, mir-223, and mir-874 were analyzed. In addition, the expression levels of il-8, il-15, occludin, and claudin-7 genes were assessed., Results: B3STA significantly upregulated the expression of mir-223, and mir-874, and downregulated mir-29a. The expression of mir-16 and mir-21 was not significant. In addition, the expression of il-8 and il-15 was not significant. B3STA significantly decreased the expression level of claudin-7 (P-value < 0.0001), but the expression of occludin was not significant. Our results showed significant correlation between all studied miRNAs, except mir-29a, with downregulation of claudin-7., Conclusions: This is the first study investigating the effects of Blastocystis sp., ST3 isolated from symptomatic subjects on the expression levels of miRNAs involved in the gut permeability. Our results demonstrated that B3STA may change miRNA expression, which are involved in the gut barrier integrity, and downregulates claudin-7, which is known as sealing factor., (© 2022. The Author(s).)
Published: 2022
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40. Isolation and identification of potentially pathogenic free-living amoeba in drinking, surface, and stagnant water sources from Alborz Province, Iran.

Author: Javanmard E, Niyyati M, Taghipour A, Fatemi M, Mirjalali H, and Karanis P
Subjects: Filtration, Humans, Iran, Water Supply, Acanthamoeba pathogenicity, Amoeba
Abstract: Free-living amoebas (FLAs) can cause neurological and ocular complications in humans. Water supplies play a critical role in transmitting FLAs to humans. The aim of the present study was to investigate the presence of FLAs in various aquatic sources including drinking water, stagnant water, and surface water in Alborz province, northern Iran, using morphological and molecular techniques. A total of 70 water samples were collected from 34 drinking waters, 23 surface waters, and 13 stagnant waters. Filtration and cultivation were employed to isolate FLAs. PCR assay was applied by using the genus-specific primers on positive samples. Pathogenicity tests (osmo- and thermo-tolerance properties) were performed for Acanthamoeba spp., positive sample. Considering the morphological criteria, four positive samples of Acanthamoeba sp., three Vermamoeba sp., two mixed Vermamoeba sp. with Vahlkamfiids, and one mixed Acanthamoeba sp. with Vahlkamfiids were isolated. Five Acanthamoeba sp. isolates were amplified using the JDP primer pairs. Among them, two genotypes, T4 (three isolates) and T5 (two isolates) corresponding to A. lenticulata, were identified. Four V. vermiformis samples were confirmed using the sequencing. This study highlighted the occurrence of potentially pathogenic waterborne FLAs in water habitats associated with high human activity. The results of such research on the prevalence of FLAs, as a human hazard, should be communicated to health policymakers.
Published: 2022
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41. Molecular Identification, Subtypes Distribution, and Alleles Discrimination of Blastocystis sp., Isolated from Immunocompromised Subjects in Iran.

Author: Mohammad Rahimi H, Karamati SA, Nemati S, Mirjalali H, and Zali MR
Abstract: Background: Blastocystis sp., is a prevalent protist isolated from humans and animals, which its opportunistic role in immunocompromised patients is still controversial. The current study aimed to evaluate the subtype and alleles distribution of Blastocystis sp., among immunocompromised patients., Methods: Totally, 33 microscopically Blastocystis -positive stool samples, isolated from Guilan province during April 2018 to May 2019 were investigated. Total DNA extraction was performed and the barcoding region of the small subunit ribosomal RNA (SSU rRNA) gene was amplified. Targeted fragments were sequenced to characterize subtypes and relevant alleles. Phylogenetic tree was constructed using Maximum-likelihood and Tamura 3-parameter to illustrate the correlation between subtypes and certain immunodeficiency., Results: Subtype analysis revealed the presence of ST1, ST2, ST3, and ST7 among 13/33 (39.4%), 5 (15.2%), 14/33 (42.4%), and 1/33 (3%), of samples, respectively. ST1 was the major subtype among cancer patients 5/7 (71.42%), while ST3 was the predominant subtype among rheumatoid arthritis (RA) patients 3/6 (50%), internal ward patients 5/10 (50%), and asthma and allergy patients 2/3 (66.66%). ST7 was isolated from a patient hospitalized in internal ward. No significant correlation was seen between the type of immunodeficiency and subtypes ( P -value = 0.771). The phylogenetic tree showed no separation regarding the type of immunodeficiency., Conclusion: Among studied immunocompromised patients, ST3 was the most prevalent subtype followed by ST1. There was no specific correlation between subtypes and alleles with type of immunodeficiency. Putative zoonotic alleles were highlighted the probability of zoonotic transmission for Blastocystis sp., Competing Interests: Conflict of interest The authors declare that they have no conflict of interest, (Copyright © 2022 Mohammad Rahimi et al. Published by Tehran University of Medical Sciences.)
Published: 2022
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42. Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects.

Author: Abdolahi S, Hosseini M, Rezaei R, Mohebbi SR, Rostami-Nejad M, Mojarad EN, Mirjalali H, Yadegar A, Asadzadeh Aghdaei H, Zali MR, and Baghaei K
Subjects: Aged, Female, Gene Expression Regulation, Healthy Volunteers, Humans, Iran, Male, Middle Aged, Angiotensin-Converting Enzyme 2 genetics, COVID-19 genetics, COVID-19 immunology, Immunity genetics, MicroRNAs genetics, SARS-CoV-2 genetics, SARS-CoV-2 immunology
Abstract: Angiotensin-converting enzyme 2 (ACE2) acts as a key receptor for the spike of SARS-CoV-2. Two main microRNAs (miRs), miR-200c-3p and miR-421-5p, are considered to modulate the expression of ACE2 gene and alterations in the expression of these miRNAs may influence the outcomes of COVID-19 infection. Accordingly, we examined whether miRNAs directing ACE2 expression altered in the SARS-CoV-2 infection. 30 patients with COVID-19 included in the study. At the time of admission and discharge, the expression of miR-200c-3p and miR-421-5p, inflammatory cytokine IL-6, and regulatory T cells' expression profiles (CD4, CD25, and Foxp3) were examined using quantitative real-time PCR method. At the time of admission, the expression levels of miR-200c-3p and miR-421-5p as well as CD4, CD25, and Foxp3 significantly decreased while IL-6 expression notably enhanced. However, by the time of discharge, the expression levels of the genes were opposite to the time of admission. Moreover, Pearson correlation analysis indicated that IL-6 expression negatively correlated with Foxp3 and miR-200c-3p expressions despite miR-421-5p and miR-200c-3p positively correlated at admission time. By manipulating miR-200c-3p and miR-421-5p expressions and controlling the ACE2 level, it is plausible to modulate the inflammation by reducing IL-6 and maintenance tolerance hemostasis during COVID-19 infection., (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
Published: 2022
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43. Toward finding the difference between untreated celiac disease and COVID-19 infected patients in terms of CD4, CD25 (IL-2 Rα), FOXP3 and IL-6 expressions as genes affecting immune homeostasis.

Author: Asri N, Nazemalhosseini Mojarad E, Mirjalali H, Mohebbi SR, Baghaei K, Rostami-Nejad M, Yadegar A, Rezaei-Tavirani M, Asadzadeh Aghdaei H, Rostami K, and Masotti A
Subjects: Adolescent, Adult, Child, Forkhead Transcription Factors genetics, Homeostasis, Humans, Interleukin-2, Interleukin-6 genetics, Middle Aged, SARS-CoV-2, T-Lymphocytes, Regulatory, Young Adult, COVID-19, Celiac Disease genetics
Abstract: Background: Coronavirus disease 2019 (COVID-19) is defined as an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 and celiac disease (CD) is one of the autoimmune multiorgan diseases, which can be accompanied by an increased risk of viral infections. CD patients, especially untreated subjects, may be at greater risk of infections such as viral illnesses. Interleukin (IL)-6, CD4, CD25, and FOXP3 are known as genes affecting immune homeostasis and relate to the inflammation state. This study aimed to compare the expression levels of aforementioned genes in peripheral blood samples of CD and severe COVID-19 patients., Methods: Sixty newly diagnosed CD patients with median age (mean ± SD) of 35.40 ± 24.12 years; thirty confirmed severe COVID-19 patients with median age (mean ± SD) of 59.67 ± 17.22, and 60 healthy subjects with median age (mean ± SD) of 35.6 ± 13.02 years; were recruited from March to September 2020. Fresh whole blood samples were collected, total RNA was obtained and cDNA synthesis was carried out. RNA expression levels of IL-6, CD4, CD25, and FOXP3 genes were assessed using real-time quantitative RT-PCR according to the 2 -∆∆Ct formula. Statistical analysis was performed using SPSS (V.21) and GraphPad, Prism (V.6)., Results: While increased expression of CD4, CD25, and FOXP3 was observed in CD patients compared to the control group (p = 0.02, p = 0.03, and p < 0.0001 respectively) and COVID-19 patients group (p < 0.0001 for all of them), their expression levels in COVID-19 patients decreased compared to controls (p < 0.0001, p = 0.01, p = 0.007, respectively). Increased IL-6 expression was observed in both groups of patients compared to controls (p < 0.0001 for both of them)., Conclusions: Although untreated CD patients may be at greater risk of developing into severe COVID-19 if they are infected by SARS-CoV-2 virus (due to their high expression of IL-6), increased expression of anti-inflammatory markers in these patients may be beneficial for them with the ability of reducing the severity of COVID-19 disease, which needs to be proven in future studies involving celiac patients infected with COVID-19., (© 2021. The Author(s).)
Published: 2021
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44. Trichostrongyloid nematodes in ruminants of northern Iran: prevalence and molecular analysis.

Author: Hosseinnezhad H, Sharifdini M, Ashrafi K, Atrkar Roushan Z, Mirjalali H, and Rahmati B
Subjects: Animals, Cattle parasitology, Goats parasitology, Iran epidemiology, Male, Phylogeny, Prevalence, Sheep parasitology, Trichostrongyloidiasis epidemiology, Ruminants parasitology, Trichostrongyloidea classification, Trichostrongyloidea isolation & purification, Trichostrongyloidiasis veterinary
Abstract: Background: This study was carried out to investigate the prevalence and analyze the molecular characteristics based on the internal transcribed spacer (ITS) 2 region of the ribosomal RNA (RNA) gene of trichostrongylid nematodes in different ruminants from Guilan province, northern of Iran., Methods: The gastrointestinal tracts of 144 ruminants including 72 cattle, 59 sheep, and 13 goats were collected from an abattoir in Guilan province during July to September 2018. After isolation the helminths, male specimens were identified based on morphological parameters. PCR and partial sequencing of the ITS2 fragment were conducted. After phylogenetic analysis, the intraspecific and interspecific differences were calculated., Results: The prevalence of total infections with the nematodes was 38.9, 74.6 and 84.6% among cattle, sheep and goats, respectively. Eleven species of trichostrongylid nematodes including Haemonchus contortus, Marshallagia marshalli, Trichostrongylus axei, T. colubriformis, T. vitrinus, Ostertagia trifurcata, Teladorsagia circumcincta, Marshallagia occidentalis, O. lyrata, O. ostertagi, and Cooperia punctate were recovered from the ruminants. The most prevalent trichostrongyloid nematodes in cattle, sheep and goats were O. ostertagi (26.4%), M. marshalli (64.4%) and T. circumcincta (69.2%), respectively. Phylogenetic tree was discriminative for Trichostrongylidae family, while phylogenetic analysis of the ITS2 gene represented low variations and no species identification of Haemonchidae and Cooperiidae families., Conclusions: This study suggests the high prevalence and species diversity of trichostrongyloid nematodes in different ruminants, indicating the importance of implement antiparasitic strategies in north regions of Iran. As well, this study showed that the ITS2 fragment is not a discriminative marker for Haemonchidae and Cooperiidae families, and investigation of other genetic markers such as mitochondrial genes would be more valuable for better understanding of their phylogenetic relationships., (© 2021. The Author(s).)
Published: 2021
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45. Soluble total antigen derived from Toxoplasma gondii RH strain prevents apoptosis, but induces anti-apoptosis in human monocyte cell line.

Author: Rahimi HM, Nemati S, Alavifard H, Baghaei K, Mirjalali H, and Zali MR
Subjects: Apoptosis, Cell Line, Humans, Monocytes, Toxoplasma, Toxoplasmosis
Abstract: Apoptosis plays crucial role in the pathogenesis of toxoplasmosis, as it limits further development of the disease. The current study aimed to investigate the effects of different concentrations of soluble total antigen (STAg) of Toxoplasma gondii (Nicolle et Manceaux, 1908) on the apoptotic and anti-apoptotic pathways. PMA-activated THP-1 cell line was sensed by T. gondii STAg and the expression patterns of caspase-3, -7, -8, -9, Bax, Bcl-2, and Mcl-1 genes were evaluated. The results showed statistically significant concentration-dependent overexpression of both Bcl-2 (P-value < 0.0001) and Mcl-1 (P-value = 0.0147). The cas-7 showed overexpression in all concentrations (P-value < 0.0001). The cas-3 was suppressed in concentrations 100, 80, and 40 µg, but statistically significant downregulated in concentrations 10 and 20 µg. The Bax was suppressed in concentrations 100 to 20 µg, while it slightly downregulated 1.42 fold (P-value = 0.0029) in concentration 10 µg. The expression of cas-8 and -9 was suppressed in all concentrations. Our results indicated that T. gondii STAg downregulated and suppressed apoptotic and upregulated anti-apoptotic pathways. The upregulation of cas-7 in this study may indicate the role of T. gondii STAg in activation of inflammatory responses.
Published: 2021
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46. Association of Blastocystis ST6 with higher protease activity among symptomatic subjects.

Author: Karamati SA, Mirjalali H, Niyyati M, Yadegar A, Asadzadeh Aghdaei H, Haghighi A, and Seyyed Tabaei SJ
Subjects: Antigens, Protozoan metabolism, Blastocystis classification, Blastocystis immunology, Blastocystis isolation & purification, Cytokines genetics, Cytokines metabolism, DNA, Protozoan genetics, Feces parasitology, Genetic Variation, HT29 Cells, Humans, Inflammation, Blastocystis enzymology, Blastocystis Infections parasitology, Cysteine Proteases metabolism, Protozoan Proteins metabolism
Abstract: Background: Blastocystis sp. is an anaerobic intestinal protozoan parasite of humans and a wide range of animals worldwide. In the current study the correlation between the cysteine protease activity of clinical samples of Blastocystis sp. ST1-3 and 6 with the levels of pro-inflammatory cytokines was evaluated., Methods: Stool samples were collected from subjects with or without clinical symptoms. All samples were cultivated in DMEM medium. The bacteria were eliminated or reduced in Blastocystis sp. positive samples subtypes 1-3 and 6 by a variety of antibiotics and consecutive sub-cultures. To prepare parasite lysate, 1 × 10 5 Blastocystis sp. from each isolate were harvested and lysed using freeze-thaw. Protease activity of each isolate was measured and the gene expression of pro-inflammatory biomarkers in HT-29 cell line sensed by isolates was investigated using quantitative Real-time PCR., Results: Protease activity assay showed inter- and intra-subtype variations among subtypes regarding the presence of symptoms, while the protease activity of symptomatic isolates was higher than asymptomatic isolates. The highest and lowest levels of protease activity were seen in ST6 and ST2, respectively. However, patterns of the expression of pro-inflammatory biomarkers in HT-29 cell line was different regarding the presence of symptoms and time points. There was no significant correlation between protease activity of different subtypes with the expression levels of pro-inflammatory biomarkers., Conclusions: Our study indicated a higher protease activity among isolates from symptomatic compared to asymptomatic subjects, suggesting functional role for proteases in clinical symptoms due to Blastocystis sp. The lack of correlation between the levels of expression of pro-inflammatory biomarkers with subtypes regarding the presence of clinical symptoms proposes the importance of host-related factors in presentation of clinical symptoms., (© 2021. The Author(s).)
Published: 2021
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47. Molecular Identification of Pathogenic Free-Living Amoeba from Household Biofilm Samples in Iran: A Risk Factor for Acanthamoeba Keratitis.

Author: Norouzi M, Saberi R, Niyyati M, Lorenzo-Morales J, Mirjalali H, Fatemi M, Javanmard E, and Karamati SA
Abstract: Free-living amoeba (FLA) are ubiquitously distributed in the environment. However, they are also the causative agents of opportunistic infections in humans and other animals. A biofilm comprises any syntrophic consortium of microorganisms in which cells stick to each other and often also to a surface. Moreover, FLA have been detected in various biofilms around the world. Therefore, the present study aimed to check for presence of FLA in samples from household biofilms in Iran and to characterize them at the molecular level. A total of 69 biofilm samples collected from showerheads, kitchen areas, and bathroom sinks were analyzed. Positive samples for FLA were characterized at the morphological and molecular levels. Furthermore, the results of morphology analysis indicated that 26.08% (18/69) of biofilm samples were positive for Acanthamoeba spp., Vermamoeba genus, and Vahlkampfiids. According to sequence analysis, five strains of Acanthamoeba isolates related to the T4 genotype and two strains belonged to the T2 genotype. In addition, the pathogenic potential of Acanthamoeba -positive isolates was conducted using the tolerance ability test. The results of BLASTn of Vermamoeba sequences were similar to what was expected for Vermamoeba vermiformis . The above-mentioned reasons revealed that the relative high contamination of household biofilm samples with FLA may pose a risk for people using soft contact lenses and for patients with traumatic cataract. Our finding proposes that filtration should be performed in shower heads and indicates the need to monitor people at increased risk of Acanthamoeba keratitis.
Published: 2021
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48. Molecular prevalence and subtype distribution of Blastocystis sp. in Asia and in Australia.

Author: Nemati S, Zali MR, Johnson P, Mirjalali H, and Karanis P
Subjects: Animals, Asia epidemiology, Australia epidemiology, DNA, Protozoan, Feces, Humans, Prevalence, Blastocystis genetics, Blastocystis Infections epidemiology
Abstract: Blastocystis is a prevalent protozoan parasite reported in humans, animals, and environmental samples. Over the past decade, numerous studies have investigated the prevalence and subtype distribution of Blastocystis sp. alongside with its genetic and biochemical features. However, studies on subtype distribution of this protozoan in humans, animals, and environmental samples represent the potential transmission routes. In this review, we evaluated studies performed in Asian countries and in Australia to provide an overview of environmental factors on the prevalence and subtype distribution of Blastocystis sp. among humans, animals, and the environment.
Published: 2021
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49. Molecular epidemiology and genotype/subtype distribution of Blastocystis sp., Enterocytozoon bieneusi, and Encephalitozoon spp. in livestock: concern for emerging zoonotic infections.

Author: Mohammad Rahimi H, Mirjalali H, and Zali MR
Subjects: Animals, Blastocystis genetics, Blastocystis Infections epidemiology, Blastocystis Infections parasitology, Cattle, Chickens, Encephalitozoon genetics, Encephalitozoonosis epidemiology, Encephalitozoonosis microbiology, Enterocytozoon genetics, Genotype, Horses, Iran epidemiology, Livestock, Microsporidiosis epidemiology, Microsporidiosis microbiology, Molecular Epidemiology, Phylogeny, Prevalence, Sheep, Zoonoses microbiology, Zoonoses parasitology, Blastocystis physiology, Encephalitozoon physiology, Enterocytozoon physiology, Zoonoses epidemiology
Abstract: Intestinal parasitic infections have high prevalence rate in many regions especially in developing countries. The aim of this study was to determine the presence and genotype/subtype of some intestinal protozoa in livestock in Iran. Stool samples were collected from cattle, sheep, chickens, and horses. The presence of targeted parasites was evaluated using real-time PCR. Genotyping/subtyping of positive samples was characterized using sequencing of the ITS and barcoding region, respectively. Blastocystis sp., 27.7% (48/173) and Enterocytozoon bieneusi 26.0% (45/173) were the most frequent protozoa followed by Encephalitozoon spp., 0.57% (1/173). Cryptosporidium spp. were not detected among samples. Encephalitozoon spp., was detected only in chickens 2.2% (1/45). A statistically correlation was seen between animals and the prevalence of targeted protozoa. E. bieneusi genotypes I (9/38; 23.68%), BEB6 (22/38; 57.89%), D (6/38; 15.79%), and horse1 (1/38; 2.63%) were detected among samples. A statistically significant correlation was seen between the genotypes and animals (P ≤ 0.05). Blastocystis sp., ST1 (1/45; 2.22%), ST5 3/45; 6.66%), ST7 (1/45; 2.22%), ST10 (24/45; 53.33%), and ST14 (16/45; 35.55%) were characterized among samples. There was no significant correlation between certain subtypes and animals (P = 0.173). The presence of zoonotic potential genotypes of E. bieneusi in animals and zoonotic potential subtypes ST1 and ST7 among our samples provide a clue about the transmission dynamic of E. bieneusi and Blastocystis sp. between animals-animals and humans-animals., (© 2021. The Author(s).)
Published: 2021
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50. Blastocystis and Clostridioides difficile: Evidence for a Synergistic Role in Colonization Among IBD Patients with Emphasis on Ulcerative Colitis.

Author: Azimirad M, Gol SMA, Javanmard E, Mirjalali H, Yadegar A, Aghdaei HA, Shahrokh S, Balaii H, Sadeghi A, and Zali MR
Subjects: Adolescent, Adult, Blastocystis genetics, Child, Clostridioides difficile genetics, Colitis, Ulcerative epidemiology, Female, Humans, Inflammatory Bowel Diseases epidemiology, Iran epidemiology, Male, Middle Aged, Polymerase Chain Reaction, Prevalence, Young Adult, Blastocystis isolation & purification, Blastocystis Infections epidemiology, Clostridioides difficile isolation & purification, Colitis, Ulcerative microbiology, Feces microbiology, Inflammatory Bowel Diseases microbiology
Abstract: Background: Regarding the controversial role of Blastocystis in inflammatory bowel diseases (IBD) patients, it seems that this protozoan may lead to an overgrowth of some non-beneficial bacteria. The current study aimed to investigate the co-existence of Blastocystis and Clostridioides difficile in IBD patients., Methods: Stool samples of 102 IBD patients were collected and cultivated for C. difficile and Blastocystis. DNA extraction was performed on positive samples and C. difficile and Blastocystis were toxinotyped and subtyped, respectively. Fisher's exact test and logistic regression were employed to calculate the correlation between the existence of Blastocystis and its subtypes (ST) with C. difficile and its type of toxins. Also, the co-existence of Blastocystis and C. difficile with the frequency of defecations was evaluated., Results: Blastocystis and C. difficile were observed in 17 (16.7%) and 26 (25.5%) of stool samples, respectively. From 26 C. difficilepositive isolates, 24 (92.3%) and 2 (7.7%) were tcdA+/B+ and tcdA+/B-, respectively. Also, 10 (58.8%) and 7 (41.2%) were Blastocystis ST1 and ST3, respectively. Statistically significant correlations between co-existence of Blastocystis and C. difficile and co-existence of these microorganisms and frequency of defecation (P < .035) were seen. There was no statistically significant correlation between subtypes of Blastocystis and colonization of C. difficile or its toxinotypes., Conclusion: The co-existence of Blastocystis and C. difficile in IBD patients was observed in the current study. Moreover, it can be proposed that these microorganisms may have synergistic effects on their colonization in the gastrointestinal tract.
Published: 2021
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