7 results on '"Mirbagheri N"'
Search Results
2. Lymph node status as a prognostic indicator after preoperative neoadjuvant chemoradiotherapy of rectal cancer.
- Author
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Deb S., Teoh W.M.K., Leow C.C., Dark J.G., Poh B.R., Mirbagheri N., Kumar B., Deb S., Teoh W.M.K., Leow C.C., Dark J.G., Poh B.R., Mirbagheri N., and Kumar B.
- Abstract
Aim: The primary aim of this study was to examine lymph node status after neoadjuvant chemoradiotherapy (CRT) using a novel scoring system describing the pathological lymph node regression grade. The proposed scoring system was based on the percentage of fibrosis and the presence of residual tumour amount. The secondary aim of the study was to assess the oncological impact of this scoring system. Method(s): The project was a retrospective cohort study over a 10-year period. Two hundred and two patients with rectal cancer who had received CRT followed by curative surgery were included. A histopathologist prospectively scored each specimen and the impact of the scoring system on survival and recurrence was analysed. Result(s): One hundred and ninety patients completed long-course preoperative CRT and formed the basis of the study. Overall, 40 recurrences (local and distant) were observed over a median follow-up of 36 months. The lymph node regression score was a significant predictor of tumour recurrence (hazard ratio 1.273, 95% CI 1.048-1.548; P = 0.015). The overall mortality rate was 21%, and a lower lymph node regression score was correlated with an improved survival curve (P = 0.01). Conclusion(s): The results demonstrate that lymph node response to neoadjuvant CRT based on a nodal regression scoring system is related to recurrence.Copyright © 2014 The Association of Coloproctology of Great Britain and Ireland.
- Published
- 2014
3. Factors predicting stomal wound closure infection rates.
- Author
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Mirbagheri N., Skinner S., Dark J., Mirbagheri N., Skinner S., and Dark J.
- Abstract
Background Stoma closure is associated with high wound infection rates. The aim of this study was to evaluate risk factors for infection rates in such wounds, with particular emphasis on assessing the importance of the stomal wound closure technique. Methods A retrospective analysis of 142 patients who had undergone ileostomy or colostomy closure between 2002 and 2011 was performed. Postoperative outcome as measured by wound infection rate was recorded. Three different closure techniques were identified: primary closure (PC), primary closure with Penrose drain (PCP) and purse-string circumferential wound approximation technique (PSC). Other factors such as age, sex, ASA score, type of prophylactic antibiotics used, diabetes, smoking and obesity were also analysed. All other techniques were excluded. Results Our series consisted of 142 stomal closures (90 ileostomy and 52 colostomy closures). The patients had a median age of 63.5 years with an interquartile range of 50.1-73.2 years. The overall wound infection rate was 10.7 %. PC, PCP and PSC were associated with wound infection rates of 17.9, 10.5 and 3.6 %, respectively. Compared to PSC, PC and PCP were associated with significantly higher wound infection rates (p = 0.027 and p = 0.068, respectively). Obesity was a significant risk factor for wound infection (p = 0.024). Use of triple-agent antibiotics prophylactically had a protective effect on the infection rate (p = 0.012). Conclusions To reduce stomal wound closure infection rates, we recommend institution of closure techniques other than PC with or without a drain. Risk factors such as obesity should be addressed, and prophylactic triple antibiotics should be administered. © Springer-Verlag Italia 2012.
- Published
- 2014
4. Sentinel node micrometastases in breast cancer: A survey of Australian and New Zealand breast surgeons.
- Author
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Harris M., Fox J., Chong C.Y.L., Mirbagheri N., Harris M., Fox J., Chong C.Y.L., and Mirbagheri N.
- Published
- 2013
5. Factors predicting stomal wound closure infection rates
- Author
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Mirbagheri, N, Dark, J, Skinner, S, Mirbagheri, N, Dark, J, and Skinner, S
- Abstract
BACKGROUND: Stoma closure is associated with high wound infection rates. The aim of this study was to evaluate risk factors for infection rates in such wounds, with particular emphasis on assessing the importance of the stomal wound closure technique. METHODS: A retrospective analysis of 142 patients who had undergone ileostomy or colostomy closure between 2002 and 2011 was performed. Postoperative outcome as measured by wound infection rate was recorded. Three different closure techniques were identified: primary closure (PC), primary closure with penrose drain (PCP) and purse-string circumferential wound approximation technique (PSC). Other factors such as age, sex, ASA score, type of prophylactic antibiotics used, diabetes, smoking and obesity were also analysed. All other techniques were excluded. RESULTS: Our series consisted of 142 stomal closures (90 ileostomy and 52 colostomy closures). The patients had a median age of 63.5 years with an interquartile range of 50.1-73.2 years. The overall wound infection rate was 10.7%. PC, PCP and PSC were associated with wound infection rates of 17.9, 10.5 and 3.6%, respectively. Compared to PSC, PC and PCP were associated with significantly higher wound infection rates (p = 0.027 and p = 0.068, respectively). Obesity was a significant risk factor for wound infection (p = 0.024). Use of triple-agent antibiotics prophylactically had a protective effect on the infection rate (p = 0.012). CONCLUSIONS: To reduce stomal wound closure infection rates, we recommend institution of closure techniques other than PC with or without a drain. Risk factors such as obesity should be addressed, and prophylactic triple antibiotics should be administered.
- Published
- 2013
6. Laser hemorrhoidoplasty in the treatment of symptomatic hemorrhoids: a pilot Australian study.
- Author
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Jain A, Lew C, Aksakal G, Hiscock R, and Mirbagheri N
- Abstract
Purpose: Traditional therapeutic approaches to the surgical management of hemorrhoid disease such as hemorrhoidectomies are plagued with severe postoperative pain and protracted recovery. Our pilot study aims to the laser hemorrhoidoplasty (LH) patients with symptomatic hemorrhoid disease that have failed conservative management for the first time in an Australian population., Methods: Thirty patients were prospectively enrolled to undergo LH. Postoperative pain, time to return to function, and quality of life (QoL) were determined through the Hemorrhoid Disease Symptom Score and Short Health Scale adapted for hemorrhoidal disease and compared to a historical group of 43 patients who underwent a Milligan-Morgan hemorrhoidectomy by the same surgeon at 3, 6, and 12 months., Results: The LH group had significantly lower mean predicted pain scores on days 1 and 2 and lower defecation pain scores and lower opioid analgesia use on days 1, 2, 3, and 4. The median time to return to normal function was significantly lower in the LH group (2 days vs. 9 days, P<0.001). Similarly, the median days to return to the workplace was significantly lower in the LH group (6 days vs. 13 days, P=0.007). During long-term follow-up (12 months), hemorrhoid symptoms and all QoL measures were significantly improved, especially among those with grade II to III disease., Conclusion: This pilot study demonstrates low pain scores with this revivified procedure in an Australian population, indicating possible expansion of the therapeutic options available for this common condition. Further head-to-head studies comparing LH to other hemorrhoid therapies are required to further determine the most efficacious therapeutic approach.
- Published
- 2024
- Full Text
- View/download PDF
7. Colorectal cancer screening in Australia: An update
- Author
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Parkin CJ, Bell SW, and Mirbagheri N
- Subjects
- Aged, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Aspirin therapeutic use, Australia, Colonoscopy methods, Colorectal Neoplasms drug therapy, Early Detection of Cancer, Female, Humans, Male, Mass Screening statistics & numerical data, Middle Aged, Risk Factors, Colorectal Neoplasms diagnosis, Mass Screening methods
- Abstract
Background: Colorectal cancer is the second most common cancer in Australia. The National Health and Medical Research Council (NHMRC) has introduced new recommendations for the prevention, early detection and management of colorectal cancer. General practitioners play a key part in the advocacy, risk stratification and implementation of colorectal cancer screening on the basis of a patient’s individual risk., Objective: The aim of this paper is to summarise the NHMRC recommendations pertaining to screening so that they may be applied in general practice., Discussion: The recommended strategy for population screening in Australia remains the immunochemical faecal occult blood test, commencing at age 50 years in asymptomatic individuals with no family history of colorectal cancer. This test is to be performed every two years to age 74 years. Individuals with a family history of colorectal cancer will need appropriate risk stratification. Aspirin should now be considered for all patients aged 50–70 years in the prevention of colorectal cancer.
- Published
- 2018
- Full Text
- View/download PDF
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