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5. NYHA classification in adults with congenital heart disease: Relation to objective measures of exercise and outcome

Author

Bredy, C, Ministeri, M, Kempny, A, Alonso-Gonzalez, R, Swan, L, Uebing, A, Diller, G-P, Gatzoulis, MA, and Dimopoulos, K

Subjects
congenital heart diseases, prognosis, Mortality, NYHA, Cardiopulmonary exercise test
Abstract

Aims The New York Heart Association functional classification (NYHA class) is often used to describe the functional capacity of adults with congenital heart disease (ACHD), albeit with limited evidence on its validity in this heterogeneous population. We aimed to validate the NYHA functional classification in ACHD by examining its relation to objective measures of limitation using cardiopulmonary exercise testing (CPET) and mortality. Methods and results This study included all ACHD patients who underwent a CPET between 2005 and 2015 at the Royal Brompton, in whom functional capacity was graded according to the NYHA classification. Congenital heart diagnoses were classified according to the Bethesda score. Time to all-cause mortality from CPET was recorded in all 2781 ACHD patients (mean age 33.8 ± 14.2 years) enrolled in the study. There was a strong relation between NYHA class and peak oxygen consumption (peak VO2), ventilation per unit in carbon dioxide production (VE/VCO2) slope and the Bethesda classification (P

Published
2017

6. Association of tricuspid regurgitation with clinical and echocardiographic outcomes after percutaneous mitral valve repair with the MitraClip System: 30-day and 12-month follow-up from the GRASP Registry

Author

Attizzani, Gf, Capodanno, DAVIDE FRANCESCO MARIA, Cannata, S, Dipasqua, F, Immé, S, Barbanti, M, Ministeri, M, Caggegi, A, Pistritto, Am, Chiarandà, M, Ronsivalle, G, Giaquinta, S, Farruggio, S, Mangiafico, S, Scandura, S, Tamburino, Corrado, Capranzano, P, and Grasso, C.

Published
2016

7. Extended use of percutaneous edge-to-edge mitral valve repair beyond EVEREST (Endovascular Valve Edge-to-Edge Repair) criteria: 30-day and 12-month clinical and echocardiographic outcomes from the GRASP (Getting Reduction of Mitral Insufficiency by Percutaneous Clip Implantation) registry

Author

Attizzani, Gf, Ohno, Y, Capodanno, DAVIDE FRANCESCO MARIA, Cannata, S, Dipasqua, F, Immé, S, Mangiafico, S, Barbanti, M, Ministeri, M, Cageggi, A, Pistritto, Am, Giaquinta, S, Farruggio, S, Chiarandà, M, Ronsivalle, G, Schnell, A, Scandura, S, Tamburino, Corrado, Capranzano, P, and Grasso, C.

Published
2015

8. Moderated Posters: Congenital heart diseaseP374Classic-pattern dyssynchrony in adult patients with a Fontan circulationP375Outcome of pregnancy in patients with coarctation of aortaP376Diffuse myocardial fibrosis is not associated with decreased contractility: a magnetic resonance T1 mapping and feature tracking studyP377Cardiovascular abnormalities in patients with osteogenesis imperfecta: case-control studyP378Serial assessment of left ventricular systolic function by speckle tracking in patients with coarctation of the aorta undergoing stentingP379Longitudinal function and ventricular dyssynchrony are restored in children with pulmonary stenosis after percutaneous balloon pulmonary valvuloplastyP380Evaluation of the relationship between ventricular end-diastolic pressure and echocardiographic measures of cardiac function in adults with a Fontan circulationP381Right ventricular remodelling after percutaneaous pulmonary valve replacement in corrected tetralogy of Fallot with severe pulmonary regurgitation.Time matters

Author

Rosner, A., primary, Quattrone, A., primary, Ide, S., primary, Mata Caballero, R., primary, Aragao, NFDV, primary, Moustafa, TAMER, primary, Cordina, R., primary, Pagourelias, E., primary, Khalapyan, T., additional, Dalen, H., additional, Mc Elhinney, D., additional, Haeffele, C., additional, Chen, S., additional, Fernandes, S., additional, Bijnens, B., additional, Friedberg, M., additional, Lui, GK., additional, Skeide, A., additional, Lindberg, H., additional, Letting, AS., additional, Langsaeter, E., additional, Estensen, ME., additional, Yim, D., additional, Riesenkampff, E., additional, Seed, M., additional, Yoo, SJ., additional, Grosse-Wortmann, L., additional, Hernandez Jimenez, V., additional, Saavedra, J., additional, Molina, L., additional, Alberca Vela, MT., additional, L Pais, J., additional, Gorriz, J., additional, Navea, C., additional, Pavon, I., additional, Alonso, JJ., additional, Borgo, JNV, additional, Davoglio, TA., additional, Jesus, CA., additional, Petisco, ACGP, additional, Le Bihan, DC., additional, Barreto, RBM, additional, Assef, JE., additional, Pedra, CA., additional, Pedra, SRFF, additional, Mahfouz, RAGAB, additional, Goda, MOHAMD, additional, Gad, MARWA, additional, Ministeri, M., additional, Celermajer, DS., additional, Uebing, A., additional, Li, W., additional, Mirea, O., additional, Duchenne, J., additional, Budts, W., additional, Bogaert, J., additional, Gewillig, M., additional, and Voigt, JU., additional

Published
2016
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9. Clinical Case Poster session 1P501The incremental value of advanced cardiovascular multi-modality imaging in the investigation of a cardiac massP502Metastatic adenocarsinoma involving the right ventricle and pulmonary artery leading right heart failureP503A malignant cause of angina in hypertrophic cardiomyopathyP504Dyspnea in a severe mitral stenotic gentleman with hypereosinophiliaP505After transcatheter aortic valve implantation be aware of infections, a case of fistulization from left ventricular outflow track to left atriumP506Myocardial infarction masking infective endocarditisP507Subendocardial abscess by contiguity of a valvular vegetationP508Real-time three-dimensional transesophageal echocardiography as compared to in vivo anatomy in a case of Candida parapsilosis native mitral valve endocarditisP509TAVI in prosthetic heart valve failure : echocardiography guided transcatether percuntaneous valve in valve implantation (VIV) for failed TAVI corevalve bioprosthesisP510Functional-anatomic matching between longitudinal strain pattern and late gadolinium enhancement of cardiac amyloidosis at presentationP511Heart failure due to masked systolic atrial contraction detected by pulmonary venous flow in a patient with ventricular pacingP512The detection of early left ventricular dysfunction by global longitudinal strain is helpful to keep in adjuvant therapy breast cancer patients till completionP513Forgotten cause of known disease: pulmonary hypertension caused by schistosomiasisP515Single coronary origin delineation by echocardiography alone in a patient with tetralogy of fallot changing the surgical planP516A rare complication after multiple valve repairP517Unusual cause of cyanosis in a young adult with cavopulmonary connectionsP518Abnormal flow in the main pulmonary artery in adult patients: a tale of 2 shuntsP519Unexpected TEE finding: mediastinal lipomatosis can fake an aortic intramural haematoma

Author

Lech, P., primary, Vatan, A., primary, Modas Daniel, P., primary, Tsai, HR., primary, Vidal Perez, RC., primary, Anwer, S., primary, Gorriz Magana, J., primary, Giavarini, A., primary, Katbeh, A., primary, Lo Iudice, F., primary, Hayashida, A., primary, Lembo, M., primary, Jamiel, AM., primary, Peacock, K., primary, Wong, CY., primary, Ministeri, M., primary, Woolf, A., primary, Carbone, A., primary, Ma, G., additional, Lee, AF., additional, Ripley, DP., additional, Karabag, T., additional, Arslan, C., additional, Yakisan, T., additional, Sak, D., additional, Galrinho, A., additional, Ramos, R., additional, Aguiar Rosa, S., additional, Viveiros Monteiro, A., additional, Branco, LM., additional, Morais, L., additional, Rodrigues, I., additional, Figueiredo, L., additional, Ferreira, RC., additional, Lin, CC., additional, Wu, HY., additional, Chen, TY., additional, Tsai, WC., additional, Castineiras Busto, M., additional, Pena Gil, C., additional, Trillo Nouche, R., additional, Lopez Otero, D., additional, Bandin Dieguez, MA., additional, Martinez Monzonis, A., additional, Gonzalez-Juanatey, JR., additional, Atef, M., additional, Hassan, N., additional, Aboulfotouh, Y., additional, Moharem-Elgamal, S., additional, Katta, A., additional, Seleem, M., additional, Meshaal, M., additional, Lopez Pais, J., additional, Monjas Garcia, S., additional, Mata Caballero, R., additional, Molina Blazquez, L., additional, Alcon Duran, B., additional, Alcocer Ayuga, M., additional, Fraile Sanz, A., additional, Saavedra Falero, J., additional, Alonso Martin, JJ., additional, Barosi, A., additional, Vanelli, P., additional, Cerchiello, M., additional, Islas Ramirez, F., additional, De Agustin, A., additional, Marcos Alberca, P., additional, Nombela, L., additional, Jimenez, P., additional, Fernandez Ortiz, A., additional, Luis Rodrigo, J., additional, Perez De Isla, L., additional, Macaya, C., additional, Petitto, M., additional, Schiano Lomoriello, V., additional, Imbriaco, M., additional, Trimarco, B., additional, Galderisi, M., additional, Kagiyama, N., additional, Hirohata, AH., additional, Yamamoto, K., additional, Yoshida, K., additional, Santoro, C., additional, Esposito, R., additional, Gerardi, D., additional, Sellitto, V., additional, Ahmed, AM., additional, Alharbi, AS., additional, Savis, A., additional, Bellsham-Revell, H., additional, Salih, C., additional, Simpson, JM., additional, Uebing, U., additional, Gatzoulis, M., additional, Li, WL., additional, Jaber, W., additional, Salerno, G., additional, Rea, G., additional, D'andrea, A., additional, Di Maio, M., additional, Limongelli, G., additional, Muto, M., additional, and Pacileo, G., additional

Published
2016
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10. Update on percutaneous mitral valve therapy: clinical results and real life experience

Author

Ussia, G. P., Cammalleri, V., Scandura, S., Immè, S., Pistritto, A. M., Ministeri, M., Chiarandà, M., Caggegi, A., Barbanti, M., Aruta, P., and Corrado TAMBURINO

Subjects
Cardiac Catheterization, Cardiac Surgical Procedures, Clinical Trials as Topic, Equipment Design, Forecasting, Humans, Mitral Valve Insufficiency, Settore MED/11 - Malattie dell'Apparato Cardiovascolare
Abstract

Mitral regurgitation (MR) is a common valvulopathy worldwide increasing in prevalence. Cardiac surgical intervention, preferable repair, is the standard of care, but a relevant number of patients with severe MR do not undergo surgery because of high peri-operative risk. Percutaneous mitral valve repair with the MitraClip System has evolved as a new tool for the treatment of severe MR. The procedure simulates the surgical edge-to-edge technique, developed by Alfieri in 1991, creating a double orifice valve by a permanent approximation of the two mitral valve leaflets. Several preclinical studies, registries and Food and Drug Administration approved clinical trials (EVEREST, ACCESS-EU) are currently available. The percutaneous approach has been recently studied in a randomized controlled trial, concluding that the device is less effective at reducing MR, when compared with surgery, by associated with a lower adverse event rate. The patients enrolled in this trial had a normal surgical risk and mainly degenerative MR with preserved left ventricular function. On the other hand, results derived from the clinical "real life" experience, show that patients actually treated in Europe present a higher surgical risk profile, more complex mitral valve anatomy and functional MR in the most of cases. Thus these data suggest that MitraClip procedure is feasible and safe in this subgroup of patients that should be excluded from the EVEREST trial due to rigid exclusion criteria. Despite the promising results clinical experience is still small, and no data related the durability are currently available. Therefore, MitraClip device should be reserved now to high risk or inoperable patients.

Published
2012

11. Association of tricuspid regurgitation with clinical and echocardiographic outcomes after percutaneous mitral valve repair with the MitraClip System: 30-day and 12-month follow-up from the GRASP Registry

Author

Ohno, Y., primary, Attizzani, G. F., additional, Capodanno, D., additional, Cannata, S., additional, Dipasqua, F., additional, Imme, S., additional, Barbanti, M., additional, Ministeri, M., additional, Caggegi, A., additional, Pistritto, A. M., additional, Chiaranda, M., additional, Ronsivalle, G., additional, Giaquinta, S., additional, Farruggio, S., additional, Mangiafico, S., additional, Scandura, S., additional, Tamburino, C., additional, Capranzano, P., additional, and Grasso, C., additional

Published
2014
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13. Reshaping of Italian Echocardiographic Laboratories Activities during the Second Wave of COVID-19 Pandemic and Expectations for the Post-Pandemic Era

Author

Ciampi, Quirino, Antonini-Canterin, Francesco, Barbieri, Andrea, Barchitta, Agata, Benedetto, Frank, Cresti, Alberto, Miceli, Sofia, Monte, Ines, Petrella, Licia, Trocino, Giuseppe, Aquila, Iolanda, Barbati, Giovanni, Barletta, Valentina, Barone, Daniele, Beraldi, Monica, Bergandi, Gianluigi, Bilardo, Giuseppe, Boriani, Giuseppe, Bossone, Eduardo, Bongarzoni, Amedeo, Bovolato, Francesca, Bursi, Francesca, Cammalleri, Valeria, Carbonella, Marco, Casavecchia, Grazia, Cicco, Sebastiano, Cioffi, Giovanni, Cocchia, Rosangela, Colonna, Paolo, Cortigiani, Lauro, Cucchini, Umberto, D'Alfonso, Maria, D’Andrea, Antonello, Dell'Angela, Luca, Dentamaro, Ilaria, Paolis, Marcella De, Stefanis, Paola De, Deste, Wanda, Fulvio, Maria Di, Giannuario, Giovanna Di, Lisi, Daniela Di, Nora, Concetta Di, Fabiani, Iacopo, Esposito, Roberta, Fazzari, Fabio, Ferrara, Luigi, Filice, Gemma, Forno, Davide, Giorgi, Mauro, Giustiniano, Enrico, Greco, Cosimo, Iannuzzi, Gian, Izzo, Annibale, Lanzone, Alberto, Malagoli, Alessandro, Mantovani, Francesca, Manuppelli, Vincenzo, Mega, Simona, Merli, Elisa, Ministeri, Margherita, Morrone, Doralisa, Napoletano, Cosimo, Nunziata, Luigi, Pastorini, Guido, Pedone, Chiara, Petruccelli, Enrica, Polito, Maria, Polizzi, Vincenzo, Prota, Costantina, Rigo, Fausto, Rivaben, Dante, Saponara, Silvio, Sciacqua, Angela, Sartori, Chiara, Scarabeo, Virginia, Serra, Walter, Severino, Sergio, Spinelli, Luciano, Tamborini, Gloria, Tota, Antonio, Villari, Bruno, Carerj, Scipione, Picano, Eugenio, Pepi, Mauro, (SIECVI), SIECoVId Study Group, on Behalf of the Italian Society of Echocardiography and Cardiovascular Imaging, Ciampi, Q., Antonini-Canterin, F., Barbieri, A., Barchitta, A., Benedetto, F., Cresti, A., Miceli, S., Monte, I., Petrella, L., Trocino, G., Aquila, I., Barbati, G., Barletta, V., Barone, D., Beraldi, M., Bergandi, G., Bilardo, G., Boriani, G., Bossone, E., Bongarzoni, A., Bovolato, F. E., Bursi, F., Cammalleri, V., Carbonella, M., Casavecchia, G., Cicco, S., Cioffi, G., Cocchia, R., Colonna, P., Cortigiani, L., Cucchini, U., D'Alfonso, M. G., D'Andrea, A., Dell'Angela, L., Dentamaro, I., De Paolis, M., De Stefanis, P., Deste, W., Di Fulvio, M., Di Giannuario, G., Di Lisi, D., Di Nora, C., Fabiani, I., Esposito, R., Fazzari, F., Ferrara, L., Filice, G., Forno, D., Giorgi, M., Giustiniano, E., Greco, C. A., Iannuzzi, G. L., Izzo, A., Lanzone, A. M., Malagoli, A., Mantovani, F., Manuppelli, V., Mega, S., Merli, E., Ministeri, M., Morrone, D., Napoletano, C., Nunziata, L., Pastorini, G., Pedone, C., Petruccelli, E., Polito, M. V., Polizzi, V., Prota, C., Rigo, F., Rivaben, D. E., Saponara, S., Sciacqua, A., Sartori, C., Scarabeo, V., Serra, W., Severino, S., Spinelli, L., Tamborini, G., Tota, A., Villari, B., Carerj, S., Picano, E., and Pepi, M.

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), COVID-19, Lung ultrasound, Point-of-care cardiac ultrasound, Carbon dioxide production, Article, Settore MED/11, Internal medicine, Pandemic, Stress Echocardiography, Medicine, echocardiography, Cardiac imaging, COVID-19, lung ultrasound, point-of-care cardiac ultrasound, lung ultrasound, point-of-care cardiac ultrasound, business.industry, speckle tracking multilayer, General Medicine, echocardiography, speckle tracking multilayer, Cardiology, Cardiac Imaging Techniques, business, Personal protection equipment
Abstract

Background: Cardiology divisions reshaped their activities during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to analyze the organization of echocardiographic laboratories and echocardiography practice during the second wave of the COVID-19 pandemic in Italy, and the expectations for the post-COVID era. Methods: We analyzed two different time periods: the month of November during the second wave of the COVID-19 pandemic (2020) and the identical month during 2019 (November 2019). Results: During the second wave of the COVID-19 pandemic, the hospital activity was partially reduced in 42 (60%) and wholly interrupted in 3 (4%) echocardiographic laboratories, whereas outpatient echocardiographic activity was partially reduced in 41 (59%) and completely interrupted in 7 (10%) laboratories. We observed an important change in the organization of activities in the echocardiography laboratory which reduced the operator-risk and improved self-protection of operators by using appropriate personal protection equipment. Operators wore FFP2 in 58 centers (83%) during trans-thoracic echocardiography (TTE), in 65 centers (93%) during transesophageal echocardiography (TEE) and 63 centers (90%) during stress echocardiography. The second wave caused a significant reduction in number of echocardiographic exams, compared to November 2019 (from 513 ± 539 to 341 ± 299 exams per center, −34%, p &lt, 0.001). On average, there was a significant increase in the outpatient waiting list for elective echocardiographic exams (from 32.0 ± 28.1 to 45.5 ± 44.9 days, +41%, p &lt, 0.001), with a reduction of in-hospital waiting list (2.9 ± 2.4 to 2.4 ± 2.0 days, −17%, p &lt, 0.001). We observed a large diffusion of point-of-care cardiac ultrasound (88%), with a significant increase of lung ultrasound usage in 30 centers (43%) during 2019, extended to all centers in 2020. Carbon dioxide production by examination is an indicator of the environmental impact of technology (100-fold less with echocardiography compared to other cardiac imaging techniques). It was ignored in 2019 by 100% of centers, and currently it is considered potentially crucial for decision-making in cardiac imaging by 65 centers (93%). Conclusions: In one year, major changes occurred in echocardiography practice and culture. The examination structure changed with extensive usage of point-of-care cardiac ultrasound and with lung ultrasound embedded by default in the TTE examination, as well as the COVID-19 testing.

Published
2021
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14. OUTCOME DI SVILUPPO A BREVE TERMINE IN SOGGETTI SOTTOPOSTI A TRATTAMENTO IPOTERMICO

Author

D'IPPOLITO, Rita Maria, E. Piro, L. Li Puma, G. Puccio, E. Tranchina, S. Napoli, V. Angileri, MANISCALCHI, Valentina, M. P. Pappalardo, M. C. Ministeri, S. M. Vitaliti, Ippolito, R., Piro, E., Li Puma, L., Puccio, G., Tranchina, E., Napoli, S., Angileri, V., Maniscalchi, V., Pappalardo, M., Ministeri, M., and Vitaliti, S.

Subjects
Trattamento ipotermico, asfissia
Abstract

Trattamento ipotermico, asfissia

Published
2015

15. Extended use of percutaneous edge-to-edge mitral valve repair beyond EVEREST (Endovascular Valve Edge-to-Edge Repair) criteria: 30-day and 12-month clinical and echocardiographic outcomes from the GRASP (Getting Reduction of Mitral Insufficiency by Percutaneous Clip Implantation) registry.

Author

Attizzani GF, Ohno Y, Capodanno D, Cannata S, Dipasqua F, Immé S, Mangiafico S, Barbanti M, Ministeri M, Cageggi A, Pistritto AM, Giaquinta S, Farruggio S, Chiarandà M, Ronsivalle G, Schnell A, Scandura S, Tamburino C, Capranzano P, and Grasso C

Subjects
Aged, Aged, 80 and over, Cardiac Surgical Procedures adverse effects, Cardiac Surgical Procedures mortality, Case-Control Studies, Feasibility Studies, Female, Hemodynamics, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Mitral Valve diagnostic imaging, Mitral Valve physiopathology, Mitral Valve Insufficiency diagnostic imaging, Mitral Valve Insufficiency mortality, Mitral Valve Insufficiency physiopathology, Predictive Value of Tests, Prospective Studies, Recovery of Function, Registries, Risk Factors, Severity of Illness Index, Time Factors, Treatment Outcome, Ultrasonography, Ventricular Function, Left, Cardiac Surgical Procedures instrumentation, Mitral Valve surgery, Mitral Valve Insufficiency surgery
Abstract

Objectives: This study sought to compare, in high-risk patients with 3+ to 4+ mitral regurgitation (MR) dichotomized by baseline echocardiographic features, acute, 30-day, and 12-month outcomes following percutaneous mitral valve repair using the MitraClip., Background: The feasibility and mid-term outcomes after MitraClip implantation in patients with echocardiographic features different from the EVEREST (Endovascular Valve Edge-to-Edge Repair) I and II trials have been scarcely studied., Methods: Clinical and echocardiographic outcomes through 12-month follow-up of consecutive patients who underwent MitraClip implantation were obtained from an ongoing prospective registry. Two different groups, divided according to baseline echocardiographic criteria (investigational group [EVERESTOFF] and control group [EVERESTON]), were compared., Results: Seventy-eight patients were included in EVERESTOFF and 93 patients in EVERESTON groups. Important and comparable acute reductions in MR and no clip-related complications were revealed. The primary safety endpoint at 30 days was comparable between groups (2.6% vs. 6.5%, respectively, p = 0.204); in addition, MR reduction was mostly sustained, whereas equivalent improvement in New York Heart Association functional class were demonstrated. Kaplan-Meier freedom from death, surgery for mitral valve dysfunction, or grade ≥3+ MR at 12 months was demonstrated in 71.4% and 76.2%, respectively, in the EVERESTOFF and EVERESTON groups (log rank p = 0.378). Significant improvements in ejection fraction and reduction in left ventricle volumes were demonstrated in both groups over time, but the baseline between-group differences were sustained., Conclusions: MitraClip implantation in patients with expanded baseline echocardiographic features, compared with the control group, was associated with similar rates of safety and efficacy through 12-month follow-up. Further validation of our findings is warranted., (Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)

Published
2015
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16. Acute left atrial spontaneous echocardiographic contrast and suspicious thrombus formation following mitral regurgitation reduction with the MitraClip system.

Author

Ohno Y, Attizzani GF, Capodanno D, Dipasqua F, Barbanti M, Cannata S, Immé S, Ministeri M, Caggegi A, Pistritto AM, Ronsivalle G, Capranzano P, Mangiafico S, Scandura S, Tamburino C, and Grasso C

Subjects
Aged, 80 and over, Female, Heart Atria diagnostic imaging, Heart Diseases etiology, Humans, Mitral Valve physiopathology, Mitral Valve Insufficiency diagnosis, Mitral Valve Insufficiency physiopathology, Predictive Value of Tests, Severity of Illness Index, Thrombosis etiology, Treatment Outcome, Cardiac Surgical Procedures adverse effects, Cardiac Surgical Procedures instrumentation, Contrast Media, Echocardiography, Doppler, Echocardiography, Three-Dimensional, Heart Diseases diagnostic imaging, Mitral Valve surgery, Mitral Valve Insufficiency surgery, Thrombosis diagnostic imaging
Published
2014
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17. Association of tricuspid regurgitation with clinical and echocardiographic outcomes after percutaneous mitral valve repair with the MitraClip System: 30-day and 12-month follow-up from the GRASP Registry.

Author

Ohno Y, Attizzani GF, Capodanno D, Cannata S, Dipasqua F, Immé S, Barbanti M, Ministeri M, Caggegi A, Pistritto AM, Chiarandà M, Ronsivalle G, Giaquinta S, Farruggio S, Mangiafico S, Scandura S, Tamburino C, Capranzano P, and Grasso C

Subjects
Aged, Comorbidity, Echocardiography, Endpoint Determination, Female, Heart Valve Prosthesis Implantation mortality, Humans, Male, Mitral Valve Insufficiency mortality, Patient Readmission statistics & numerical data, Retrospective Studies, Treatment Outcome, Tricuspid Valve Insufficiency mortality, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation methods, Mitral Valve surgery, Mitral Valve Insufficiency surgery, Tricuspid Valve Insufficiency surgery
Abstract

Aim: The aim of this study was to evaluate the association of baseline tricuspid regurgitation (TR) on the outcomes after percutaneous mitral valve repair (PMVR) with the MitraClip system., Methods and Results: Data from 146 consecutive patients with functional mitral regurgitation (MR) were obtained. Two different groups, dichotomized according to the degree of pre-procedural TR (moderate/severe, n = 47 and none/mild, n = 99), had their clinical and echocardiographic outcomes through 12-month compared. At 30-day, the primary safety endpoint was significantly higher in moderate/severe TR compared with none/mild TR (10.6 vs. 2.0%, P = 0.035). Marked reduction in MR grades observed post-procedure were maintained through 12 months. Although NYHA functional class significantly improved in both groups compared with baseline, it was impaired in moderate/severe TR compared with the none/mild TR group (NYHA > II at 30 day: 33.3 vs. 9.2%, P < 0.001; at 1 year: 38.5 vs. 12.3%, respectively, P = 0.006). Left ventricle reverse remodelling and ejection fraction improvement were revealed in both groups. The primary efficacy endpoint at 12-month determined by freedom from death, surgery for mitral valve dysfunction, or grade ≥ 3+ MR was comparable between groups, but combined death and re-hospitalization for heart failure rates were higher in the moderate/severe TR group. Multivariable Cox regression analysis demonstrated that baseline moderate/severe TR and chronic kidney disease were independent predictors of this combined endpoint., Conclusions: Although PMVR with MitraClip led to improvement in MR, TR, and NYHA functional class in patients with baseline moderate/severe TR, the primary safety endpoint at 30-day was impaired, while moderate/severe TR independently predicted death and re-hospitalization for heart failure at 12-month., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.)

Published
2014
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18. Catheter-based edge-to-edge mitral valve repair after percutaneous mitral valve annuloplasty failure.

Author

Grasso C, Attizzani GF, Ohno Y, Dipasqua F, Mangiafico S, Ministeri M, Caggegi A, Cannata S, Scandura S, and Tamburino C

Subjects
Aged, Coronary Angiography, Echocardiography, Doppler, Color, Echocardiography, Three-Dimensional, Female, Humans, Mitral Valve diagnostic imaging, Mitral Valve physiopathology, Mitral Valve Insufficiency diagnosis, Mitral Valve Insufficiency physiopathology, Mitral Valve Insufficiency surgery, Severity of Illness Index, Treatment Failure, Cardiac Catheterization instrumentation, Mitral Valve surgery, Mitral Valve Annuloplasty, Mitral Valve Insufficiency therapy
Published
2014
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19. Percutaneous mitral valve repair with the MitraClip system for severe mitral regurgitation in patients with surgical mitral valve repair failure.

Author

Grasso C, Ohno Y, Attizzani GF, Cannata S, Immè S, Barbanti M, Pistritto AM, Ministeri M, Caggegi A, Chiarandà M, Dipasqua F, Ronsivalle G, Mangiafico S, Scandura S, Capranzano P, Capodanno D, and Tamburino C

Subjects
Aged, Female, Follow-Up Studies, Humans, Male, Mitral Valve diagnostic imaging, Mitral Valve surgery, Prospective Studies, Ultrasonography, Mitral Valve Insufficiency diagnostic imaging, Mitral Valve Insufficiency surgery, Prosthesis Failure, Severity of Illness Index, Surgical Instruments statistics & numerical data
Published
2014
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