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1. Regulating the timing of CENP-A nucleosome assembly by phosphorylation.

Author

Miell MD and Straight AF

Subjects
CDC2 Protein Kinase, Centromere Protein A, Humans, Autoantigens metabolism, Cell Cycle physiology, Centromere physiology, Chromosomal Proteins, Non-Histone metabolism, Cyclin-Dependent Kinases metabolism, DNA-Binding Proteins metabolism, Protein Phosphatase 1 metabolism, Serine metabolism
Abstract

In this issue of Developmental Cell, Yu et al. (2015) demonstrate that CENP-A phosphorylation by CDK1 inhibits its association with the chaperone protein HJURP and that the removal of this modification at mitotic exit is a key regulatory event that controls the timing of new CENP-A nucleosome formation at centromeres., (Copyright © 2015 Elsevier Inc. All rights reserved.)

Published
2015
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3. CENP-A confers a reduction in height on octameric nucleosomes.

Author

Miell MD, Fuller CJ, Guse A, Barysz HM, Downes A, Owen-Hughes T, Rappsilber J, Straight AF, and Allshire RC

Subjects
Centromere Protein A, Humans, Microscopy, Atomic Force, Autoantigens metabolism, Chromosomal Proteins, Non-Histone metabolism, Nucleosomes metabolism, Nucleosomes ultrastructure
Abstract

Nucleosomes with histone H3 replaced by CENP-A direct kinetochore assembly. CENP-A nucleosomes from human and Drosophila have been reported to have reduced heights as compared to canonical octameric H3 nucleosomes, thus suggesting a unique tetrameric hemisomal composition. We demonstrate that octameric CENP-A nucleosomes assembled in vitro exhibit reduced heights, indicating that they are physically distinct from H3 nucleosomes and negating the need to invoke the presence of hemisomes.

Published
2013
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