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2. Biophysical Parameters During Radiofrequency Catheter Ablation of Scar‐Mediated Ventricular Tachycardia: Epicardial and Endocardial Applications via Manual and Magnetic Navigation

Author

BOURKE, TARA, BUCH, ERIC, MATHURIA, NILESH, MICHOWITZ, YOAV, YU, RICKY, MANDAPATI, RAVI, SHIVKUMAR, KALYANAM, and TUNG, RODERICK

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Cardiovascular, Adult, Aged, Aged, 80 and over, Catheter Ablation, Cicatrix, Electrocardiography, Endocardium, Female, Humans, Magnetics, Male, Middle Aged, Monitoring, Intraoperative, Pericardium, Retrospective Studies, Tachycardia, Ventricular, ventricular tachycardia, radiofrequency, ablation, biophysical, scar, endocardial, epicardial, Ablation, Biophysical, Endocardial, Epicardial, Radiofrequency, Scar, Ventricular tachycardia, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundThere is a paucity of data on biophysical parameters during radiofrequency ablation of scar-mediated ventricular tachycardia (VT).Methods and resultsData were collected from consecutive patients undergoing VT ablation with open-irrigation. Complete data were available for 372 lesions in 21 patients. The frequency of biophysical parameter changes were: >10Ω reduction (80%), bipolar EGM reduction (69%), while loss of capture was uncommon (32%). Unipolar injury current was seen in 72% of radiofrequency applications. Both EGM reduction and impedance drop were seen in 57% and a change in all 3 parameters was seen in only 20% of lesions. Late potentials were eliminated in 33%, reduced/modified in 56%, and remained after ablation in 11%. Epicardial lesions exhibited an impedance drop (90% vs. 76%, P = 0.002) and loss of capture (46% vs. 27%, P < 0.001) more frequently than endocardial lesions. Lesions delivered manually exhibited a >10Ω impedance drop (83% vs. 71%, P = 0.02) and an EGM reduction (71% vs. 40%, P < 0.001) more frequently than lesions applied using magnetic navigation, although loss of capture, elimination of LPs, and a change in all 3 parameters were similarly observed.ConclusionsVT ablation is inefficient as the majority of radiofrequency lesions do not achieve more than one targeted biophysical parameter. Only one-third of RF applications targeted at LPs result in complete elimination. Epicardial ablation within scar may be more effective than endocardial lesions, and lesions applied manually may be more effective than lesions applied using magnetic navigation. New technologies directed at identifying and optimizing ablation effectiveness in scar are clinically warranted.

Published
2014

3. Characterization and Management of Arrhythmic Events in Young Patients With Brugada Syndrome

Author

Michowitz, Yoav, Milman, Anat, Andorin, Antoine, Sarquella-Brugada, Georgia, Gonzalez Corcia, M. Cecilia, Gourraud, Jean-Baptiste, Conte, Giulio, Sacher, Frederic, Juang, Jimmy J.M., Kim, Sung-Hwan, Leshem, Eran, Mabo, Philippe, Postema, Pieter G., Hochstadt, Aviram, Wijeyeratne, Yanushi D., Denjoy, Isabelle, Giustetto, Carla, Mizusawa, Yuka, Huang, Zhengrong, Jespersen, Camilla H., Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Arbelo, Elena, Mazzanti, Andrea, Allocca, Giuseppe, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Priori, Silvia G., Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Brugada, Josep, Kusano, Kengo F., Hirao, Kenzo, Calo, Leonardo, Takagi, Masahiko, Tfelt-Hansen, Jacob, Yan, Gan-Xin, Gaita, Fiorenzo, Leenhardt, Antoine, Behr, Elijah R., Wilde, Arthur A.M., Nam, Gi-Byoung, Brugada, Pedro, Probst, Vincent, and Belhassen, Bernard

Published
2019
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5. Guía ESC 2021 sobre estimulación cardiaca y terapia de resincronización

Author

Glikson, Michael, Nielsen, Jens Cosedis, Kronborg, Mads Brix, Michowitz, Yoav, Auricchio, Angelo, Barbash, Israel Moshe, Barrabés, José A., Boriani, Giuseppe, Braunschweig, Frieder, Brignole, Michele, Burri, Haran, Coats, Andrew J.S., Deharo, Jean-Claude, Delgado, Victoria, Diller, Gerhard-Paul, Israel, Carsten W., Keren, Andre, Knops, Reinoud E., Kotecha, Dipak, Leclercq, Christophe, Merkely, Bela, Starck, Christoph, Thylén, Ingela, and Tolosana, José María

Published
2022
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6. Post-transcatheter aortic valve implantation isolated PR prolongation: incidence and clinical significance.

Author

Perel, Nimrod, Tovia-Brodie, Oholi, Schnur, Asher, Acha, Moshe Rav, Levi, Nir, Cohen, Yogev, Dvir, Danny, Glikson, Michael, and Michowitz, Yoav

Abstract

Aims Conduction abnormalities post-transcatheter aortic valve implantation (TAVI) are common. Post-TAVI PR prolongation was mainly studied as an adjunct to new-onset bundle branch block. The net effect of isolated PR prolongation (IPRP) without post-TAVI QRS changes is not well known. The aim of this study was to define the incidence and clinical significance of post-TAVI IPRP. Methods and results A total of 1108 consecutive TAVI patients were reviewed. Patients with IPRP were compared with patients without post-TAVI electrocardiogram (ECG) changes. Clinical outcomes included permanent pacemaker implantation (PPI) and overall mortality. A total of 146 patients with IPRP were compared with 290 patients without post-TAVI ECG changes. At 1 year follow-up, 4 (2.7%) and 7 (2.4%) patients underwent PPI (P = 0.838) and 10 (6.8%) and 25 (8.6%) died (P = 0.521), from the study and control groups, respectively. No patient with IPRP and narrow QRS underwent PPI during 1 year post-TAVI, and all death events were non-cardiac except one unknown cause. Permanent pacemaker implantation rates among patients with IPRP and wide QRS were higher (n = 4, 12.1%), compared with patients with wide QRS without post-TAVI ECG change (n = 3, 4%) however not reaching statistical significance (P = 0.126). Multivariate Cox proportional hazards model demonstrated that in patients with narrow QRS, neither PR prolongation nor baseline or maximal PR intervals was associated with the combined endpoint of PPI and mortality. However, in patients with wide QRS, baseline PR intervals and QRS width, but not PR prolongation were associated with the combined outcome. Conclusion Post-TAVI IPRP in patients with narrow QRS is not associated with adverse outcome. This finding may translate clinically into a more permissive approach to these patients. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Cryoballoon-Induced Circumferential Pulmonary Vein Fibrosis, Assessed by Late Gadolinium-Enhancement Cardiac Magnetic Resonance Imaging, and Its Correlation with Clinical Atrial Fibrillation Recurrence

Author

Rav Acha, Moshe, primary, Tovia-Brodie, Oholi, additional, Michowitz, Yoav, additional, Bayya, Feras, additional, Shaheen, Fauzi F., additional, Abuhatzera, Shalom, additional, Medina, Aharon, additional, Glikson, Michael, additional, and Wolak, Arik, additional

Published
2023
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8. Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia.

Author

Laredo, Mikael, Tovia-Brodie, Oholi, Milman, Anat, Michowitz, Yoav, Roudijk, Rob RW, Peretto, Giovanni, Badenco, Nicolas, Te Riele, Anneline ASJM, Sala, Simone, Duthoit, Guillaume, Arbelo, Elena, Ninni, Sandro, Gasperetti, Alessio, van Tintelen, Peter JP, Paglino, Gabriele, Waintraub, Xavier, Andorin, Antoine, Peichl, Petr, Bosman, Laurens P, Calo, Leonardo, Giustetto, Carla, Radinovic, Andrea, Jorda, Paloma, Casado Arroyo, Ruben, Zorio, Esther, Bermúdez-Jiménez, Francisco FJ, Behr, Elijah Raphael, Havranek, Stepan, Tfelt-Hansen, Jacob, Sacher, Frédéric, Hermida, Jean-Sylvain, Nof, Eyal, Casella, Michela, Kautzner, Josef, Lacroix, Dominique, Brugada, Josep, Duru, Firat, Bella, Paolo Della, Gandjbakhch, Estelle, Hauer, Richard, Belhassen, Bernard, Laredo, Mikael, Tovia-Brodie, Oholi, Milman, Anat, Michowitz, Yoav, Roudijk, Rob RW, Peretto, Giovanni, Badenco, Nicolas, Te Riele, Anneline ASJM, Sala, Simone, Duthoit, Guillaume, Arbelo, Elena, Ninni, Sandro, Gasperetti, Alessio, van Tintelen, Peter JP, Paglino, Gabriele, Waintraub, Xavier, Andorin, Antoine, Peichl, Petr, Bosman, Laurens P, Calo, Leonardo, Giustetto, Carla, Radinovic, Andrea, Jorda, Paloma, Casado Arroyo, Ruben, Zorio, Esther, Bermúdez-Jiménez, Francisco FJ, Behr, Elijah Raphael, Havranek, Stepan, Tfelt-Hansen, Jacob, Sacher, Frédéric, Hermida, Jean-Sylvain, Nof, Eyal, Casella, Michela, Kautzner, Josef, Lacroix, Dominique, Brugada, Josep, Duru, Firat, Bella, Paolo Della, Gandjbakhch, Estelle, Hauer, Richard, and Belhassen, Bernard

Abstract

Little is known about patients with right bundle branch block (RBBB)-ventricular tachycardia (VT) and arrhythmogenic cardiomyopathy (ACM). Our aims were: (i) to describe electrocardiogram (ECG) characteristics of sinus rhythm (SR) and VT; (ii) to correlate SR with RBBB-VT ECGs; and (iii) to compare VT ECGs with electro-anatomic mapping (EAM) data., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

9. Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS.

Author

Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frédéric, Mabo, Philippe, Kim, SungHwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi YD, Mazzanti, Andrea, Brugada, Ramon, Casado Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah Raphael, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo KF, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frédéric, Mabo, Philippe, Kim, SungHwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi YD, Mazzanti, Andrea, Brugada, Ramon, Casado Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah Raphael, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo KF, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

10. Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram:Sub-Analysis From the SABRUS

Author

Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D, Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D, Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Published
2023

11. Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia

Author

Arts Assistenten Cardiologie, Onderzoek Precision medicine, Circulatory Health, Genetica, Cancer, Child Health, Team Medisch, Laredo, Mikael, Tovia-Brodie, Oholi, Milman, Anat, Michowitz, Yoav, Roudijk, Rob W, Peretto, Giovanni, Badenco, Nicolas, Te Riele, Anneline S J M, Sala, Simone, Duthoit, Guillaume, Arbelo, Elena, Ninni, Sandro, Gasperetti, Alessio, van Tintelen, J Peter, Paglino, Gabriele, Waintraub, Xavier, Andorin, Antoine, Peichl, Petr, Bosman, Laurens P, Calo, Leonardo, Giustetto, Carla, Radinovic, Andrea, Jorda, Paloma, Casado-Arroyo, Ruben, Zorio, Esther, Bermúdez-Jiménez, Francisco J, Behr, Elijah R, Havranek, Stepan, Tfelt-Hansen, Jacob, Sacher, Frederic, Hermida, Jean-Sylvain, Nof, Eyal, Casella, Michela, Kautzner, Josef, Lacroix, Dominique, Brugada, Josep, Duru, Firat, Bella, Paolo Della, Gandjbakhch, Estelle, Hauer, Richard, Belhassen, Bernard, Arts Assistenten Cardiologie, Onderzoek Precision medicine, Circulatory Health, Genetica, Cancer, Child Health, Team Medisch, Laredo, Mikael, Tovia-Brodie, Oholi, Milman, Anat, Michowitz, Yoav, Roudijk, Rob W, Peretto, Giovanni, Badenco, Nicolas, Te Riele, Anneline S J M, Sala, Simone, Duthoit, Guillaume, Arbelo, Elena, Ninni, Sandro, Gasperetti, Alessio, van Tintelen, J Peter, Paglino, Gabriele, Waintraub, Xavier, Andorin, Antoine, Peichl, Petr, Bosman, Laurens P, Calo, Leonardo, Giustetto, Carla, Radinovic, Andrea, Jorda, Paloma, Casado-Arroyo, Ruben, Zorio, Esther, Bermúdez-Jiménez, Francisco J, Behr, Elijah R, Havranek, Stepan, Tfelt-Hansen, Jacob, Sacher, Frederic, Hermida, Jean-Sylvain, Nof, Eyal, Casella, Michela, Kautzner, Josef, Lacroix, Dominique, Brugada, Josep, Duru, Firat, Bella, Paolo Della, Gandjbakhch, Estelle, Hauer, Richard, and Belhassen, Bernard

Published
2023

12. Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia

Author

Laredo, Mikael; https://orcid.org/0000-0002-7326-2656, Tovia-Brodie, Oholi, Milman, Anat, Michowitz, Yoav, Roudijk, Rob W, Peretto, Giovanni, Badenco, Nicolas, Te Riele, Anneline S J M, Sala, Simone, Duthoit, Guillaume, Arbelo, Elena, Ninni, Sandro, Gasperetti, Alessio, van Tintelen, J Peter, Paglino, Gabriele, Waintraub, Xavier, Andorin, Antoine, Peichl, Petr, Bosman, Laurens P, Calo, Leonardo, Giustetto, Carla, Radinovic, Andrea, Jorda, Paloma, Casado-Arroyo, Ruben, Zorio, Esther, Bermúdez-Jiménez, Francisco J, Behr, Elijah R, Havranek, Stepan, Tfelt-Hansen, Jacob, Sacher, Frederic, Duru, Firat; https://orcid.org/0000-0002-4748-0158, et al, Laredo, Mikael; https://orcid.org/0000-0002-7326-2656, Tovia-Brodie, Oholi, Milman, Anat, Michowitz, Yoav, Roudijk, Rob W, Peretto, Giovanni, Badenco, Nicolas, Te Riele, Anneline S J M, Sala, Simone, Duthoit, Guillaume, Arbelo, Elena, Ninni, Sandro, Gasperetti, Alessio, van Tintelen, J Peter, Paglino, Gabriele, Waintraub, Xavier, Andorin, Antoine, Peichl, Petr, Bosman, Laurens P, Calo, Leonardo, Giustetto, Carla, Radinovic, Andrea, Jorda, Paloma, Casado-Arroyo, Ruben, Zorio, Esther, Bermúdez-Jiménez, Francisco J, Behr, Elijah R, Havranek, Stepan, Tfelt-Hansen, Jacob, Sacher, Frederic, Duru, Firat; https://orcid.org/0000-0002-4748-0158, and et al

Abstract

AIMS: Little is known about patients with right bundle branch block (RBBB)-ventricular tachycardia (VT) and arrhythmogenic cardiomyopathy (ACM). Our aims were: (i) to describe electrocardiogram (ECG) characteristics of sinus rhythm (SR) and VT; (ii) to correlate SR with RBBB-VT ECGs; and (iii) to compare VT ECGs with electro-anatomic mapping (EAM) data. METHODS AND RESULTS: From the European Survey on ACM, 70 patients with spontaneous RBBB-VT were included. Putative left ventricular (LV) sites of origin (SOOs) were estimated with a VT-axis-derived methodology and confirmed by EAM data when available. Overall, 49 (70%) patients met definite Task Force Criteria. Low QRS voltage predominated in lateral leads (n = 37, 55%), but QRS fragmentation was more frequent in inferior leads (n = 15, 23%). T-wave inversion (TWI) was equally frequent in inferior (n = 28, 42%) and lateral (n = 27, 40%) leads. TWI in inferior leads was associated with reduced LV ejection fraction (LVEF; 46 ± 10 vs. 53 ± 8, P = 0.02). Regarding SOOs, the inferior wall harboured 31 (46%) SOOs, followed by the lateral wall (n = 17, 25%), the anterior wall (n = 15, 22%), and the septum (n = 4, 6%). EAM data were available for 16 patients and showed good concordance with the putative SOOs. In all patients with superior-axis RBBB-VT who underwent endo-epicardial VT activation mapping, VT originated from the LV. CONCLUSIONS: In patients with ACM and RBBB-VT, RBBB-VTs originated mainly from the inferior and lateral LV walls. SR depolarization and repolarization abnormalities were frequent and associated with underlying variants.

Published
2023

13. Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia

Author

Laredo, Mikael, primary, Tovia-Brodie, Oholi, additional, Milman, Anat, additional, Michowitz, Yoav, additional, Roudijk, Rob W, additional, Peretto, Giovanni, additional, Badenco, Nicolas, additional, te Riele, Anneline S J M, additional, Sala, Simone, additional, Duthoit, Guillaume, additional, Arbelo, Elena, additional, Ninni, Sandro, additional, Gasperetti, Alessio, additional, van Tintelen, J Peter, additional, Paglino, Gabriele, additional, Waintraub, Xavier, additional, Andorin, Antoine, additional, Peichl, Petr, additional, Bosman, Laurens P, additional, Calo, Leonardo, additional, Giustetto, Carla, additional, Radinovic, Andrea, additional, Jorda, Paloma, additional, Casado-Arroyo, Ruben, additional, Zorio, Esther, additional, Bermúdez-Jiménez, Francisco J, additional, Behr, Elijah R, additional, Havranek, Stepan, additional, Tfelt-Hansen, Jacob, additional, Sacher, Frederic, additional, Hermida, Jean-Sylvain, additional, Nof, Eyal, additional, Casella, Michela, additional, Kautzner, Josef, additional, Lacroix, Dominique, additional, Brugada, Josep, additional, Duru, Firat, additional, Bella, Paolo Della, additional, Gandjbakhch, Estelle, additional, Hauer, Richard, additional, and Belhassen, Bernard, additional

Published
2023
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14. Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS

Author

Milman, Anat, primary, Sabbag, Avi, additional, Conte, Giulio, additional, Postema, Pieter G., additional, Andorin, Antoine, additional, Gourraud, Jean-Baptiste, additional, Sacher, Frederic, additional, Mabo, Philippe, additional, Kim, Sung-Hwan, additional, Maeda, Shingo, additional, Takahashi, Yoshihide, additional, Kamakura, Tsukasa, additional, Aiba, Takeshi, additional, Juang, Jimmy JM, additional, Michowitz, Yoav, additional, Leshem, Eran, additional, Mizusawa, Yuka, additional, Arbelo, Elena, additional, Huang, Zhengrong, additional, Denjoy, Isabelle, additional, Giustetto, Carla, additional, Wijeyeratne, Yanushi D., additional, Mazzanti, Andrea, additional, Brugada, Ramon, additional, Casado-Arroyo, Ruben, additional, Champagne, Jean, additional, Calo, Leonardo, additional, Sarquella-Brugada, Georgia, additional, Tfelt-Hansen, Jacob, additional, Priori, Silvia G., additional, Takagi, Masahiko, additional, Veltmann, Christian, additional, Delise, Pietro, additional, Corrado, Domenico, additional, Behr, Elijah R., additional, Gaita, Fiorenzo, additional, Yan, Gan-Xin, additional, Brugada, Josep, additional, Leenhardt, Antoine, additional, Wilde, Arthur A.M., additional, Brugada, Pedro, additional, Kusano, Kengo F., additional, Hirao, Kenzo, additional, Nam, Gi-Byoung, additional, Probst, Vincent, additional, and Belhassen, Bernard, additional

Published
2023
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16. Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients

Author

Milman, Anat, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Juang, Jimmy J.M., Leshem, Eran, Rahkovich, Michael, Hochstadt, Aviram, Mizusawa, Yuka, Postema, Pieter G., Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D., Napolitano, Carlo, Michowitz, Yoav, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G., Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Published
2017
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17. Grupo de trabajo sobre estimulación cardiaca y terapia de resincronización cardiaca de la Sociedad Europea de Cardiología (ESC): Desarrollada en colaboración con la European Heart Rhythm Association (EHRA)

Author

Glikson, Michael, Nielsen, Jens Cosedis, Kronborg, Mads Brix, Michowitz, Yoav, Auricchio, Angelo, Barbash, Israel Moshe, Barrabés, José A., Boriani, Giuseppe, Braunschweig, Frieder, Brignole, Michele, Burri, Haran, Coats, Andrew J. S., Deharo, Jean-Claude, Delgado, Victoria, Diller, Gerhard-Paul, Israel, Carsten W., Keren, Andre, Knops, Reinoud E., Kotecha, Dipak, Leclercq, Christophe, Merkely, Bela, Starck, Christoph, Thylén, Ingela, Tolosana, José María, Cardiology, and ACS - Heart failure & arrhythmias

Published
2022

18. European Society of Cardiology Quality Indicators for the care and outcomes of cardiac pacing:developed by the Working Group for Cardiac Pacing Quality Indicators in collaboration with the European Heart Rhythm Association of the European Society of Cardiology

Author

Aktaa, Suleman, Abdin, Amr, Arbelo, Elena, Burri, Haran, Vernooy, Kevin, Blomström-lundqvist, Carina, Boriani, Giuseppe, Defaye, Pascal, Deharo, Jean-claude, Drossart, Inga, Foldager, Dan, Gold, Michael R, Johansen, Jens Brock, Leyva-Leon, Francisco, Linde, Cecilia, Michowitz, Yoav, Kronborg, Mads Brix, Slotwiner, David, Steen, Torkel, Tolosana, José Maria, Tzeis, Stylianos, Varma, Niraj, Glikson, Michael, Nielsen, Jens Cosedis, Gale, Chris P, Aktaa, Suleman, Abdin, Amr, Arbelo, Elena, Burri, Haran, Vernooy, Kevin, Blomström-lundqvist, Carina, Boriani, Giuseppe, Defaye, Pascal, Deharo, Jean-claude, Drossart, Inga, Foldager, Dan, Gold, Michael R, Johansen, Jens Brock, Leyva-Leon, Francisco, Linde, Cecilia, Michowitz, Yoav, Kronborg, Mads Brix, Slotwiner, David, Steen, Torkel, Tolosana, José Maria, Tzeis, Stylianos, Varma, Niraj, Glikson, Michael, Nielsen, Jens Cosedis, and Gale, Chris P

Abstract

Aims: To develop a suite of quality indicators (QIs) for the evaluation of the care and outcomes for adults undergoing cardiac pacing. Methods and results: Under the auspice of the Clinical Practice Guideline Quality Indicator Committee of the European Society of Cardiology (ESC), the Working Group for cardiac pacing QIs was formed. The Group comprised Task Force members of the 2021 ESC Clinical Practice Guidelines on Cardiac Pacing and Cardiac Resynchronization Therapy, members of the European Heart Rhythm Association, international cardiac device experts, and patient representatives. We followed the ESC methodology for QI development, which involved (i) the identification of the key domains of care by constructing a conceptual framework of the management of patients receiving cardiac pacing, (ii) the development of candidate QIs by conducting a systematic review of the literature, (iii) the selection of the final set of QIs using a modified-Delphi method, and (iv) the evaluation of the feasibility of the developed QIs. Four domains of care were identified: (i) structural framework, (ii) patient assessment, (iii) pacing strategy, and (iv) clinical outcomes. In total, seven main and four secondary QIs were selected across these domains and were embedded within the 2021 ESC Guidelines on Cardiac Pacing and Cardiac Resynchronization therapy. Conclusion: By way of a standardized process, 11 QIs for cardiac pacing were developed. These indicators may be used to quantify adherence to guideline-recommended clinical practice and have the potential to improve the care and outcomes of patients receiving cardiac pacemakers.

Published
2022

19. European Society of Cardiology Quality Indicators for the care and outcomes of cardiac pacing : developed by the Working Group for Cardiac Pacing Quality Indicators in collaboration with the European Heart Rhythm Association of the European Society of Cardiology

Author

Aktaa, Suleman, Abdin, Amr, Arbelo, Elena, Burri, Haran, Vernooy, Kevin, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Defaye, Pascal, Deharo, Jean-Claude, Drossart, Inga, Foldager, Dan, Gold, Michael R, Johansen, Jens Brock, Leyva, Francisco, Linde, Cecilia, Michowitz, Yoav, Kronborg, Mads Brix, Slotwiner, David, Steen, Torkel, Tolosana, José Maria, Tzeis, Stylianos, Varma, Niraj, Glikson, Michael, Nielsen, Jens Cosedis, Gale, Chris P, Aktaa, Suleman, Abdin, Amr, Arbelo, Elena, Burri, Haran, Vernooy, Kevin, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Defaye, Pascal, Deharo, Jean-Claude, Drossart, Inga, Foldager, Dan, Gold, Michael R, Johansen, Jens Brock, Leyva, Francisco, Linde, Cecilia, Michowitz, Yoav, Kronborg, Mads Brix, Slotwiner, David, Steen, Torkel, Tolosana, José Maria, Tzeis, Stylianos, Varma, Niraj, Glikson, Michael, Nielsen, Jens Cosedis, and Gale, Chris P

Abstract

AIMS: To develop a suite of quality indicators (QIs) for the evaluation of the care and outcomes for adults undergoing cardiac pacing. METHODS AND RESULTS: Under the auspice of the Clinical Practice Guideline Quality Indicator Committee of the European Society of Cardiology (ESC), the Working Group for cardiac pacing QIs was formed. The Group comprised Task Force members of the 2021 ESC Clinical Practice Guidelines on Cardiac Pacing and Cardiac Resynchronization Therapy, members of the European Heart Rhythm Association, international cardiac device experts, and patient representatives. We followed the ESC methodology for QI development, which involved (i) the identification of the key domains of care by constructing a conceptual framework of the management of patients receiving cardiac pacing, (ii) the development of candidate QIs by conducting a systematic review of the literature, (iii) the selection of the final set of QIs using a modified-Delphi method, and (iv) the evaluation of the feasibility of the developed QIs. Four domains of care were identified: (i) structural framework, (ii) patient assessment, (iii) pacing strategy, and (iv) clinical outcomes. In total, seven main and four secondary QIs were selected across these domains and were embedded within the 2021 ESC Guidelines on Cardiac Pacing and Cardiac Resynchronization therapy. CONCLUSION: By way of a standardized process, 11 QIs for cardiac pacing were developed. These indicators may be used to quantify adherence to guideline-recommended clinical practice and have the potential to improve the care and outcomes of patients receiving cardiac pacemakers.

Published
2022
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20. Lead fixation mechanism impacts outcome of transvenous lead extraction : Data from the European Lead Extraction ConTRolled Registry

Author

Levi, Nir, Bongiorni, Maria Grazia, Rav Acha, Moshe, Tovia-Brodie, Oholi, Kennergren, Charles, Auricchio, Angelo, Maggioni, Aldo Pietro, Rinaldi, Christopher A, Nof, Eyal, Ilan, Michael, Blomström-Lundqvist, Carina, Deharo, Jean-Claude, Leclercq, Christophe, Glikson, Michael, Michowitz, Yoav, Levi, Nir, Bongiorni, Maria Grazia, Rav Acha, Moshe, Tovia-Brodie, Oholi, Kennergren, Charles, Auricchio, Angelo, Maggioni, Aldo Pietro, Rinaldi, Christopher A, Nof, Eyal, Ilan, Michael, Blomström-Lundqvist, Carina, Deharo, Jean-Claude, Leclercq, Christophe, Glikson, Michael, and Michowitz, Yoav

Abstract

AIMS: The aims of this study is to characterize the transvenous lead extraction (TLE) population with active (A) compared with passive fixation (PFix) leads and to compare the safety, efficacy, and ease of extracting active fixation (AFix) compared with PFix right atrial (RA) and right ventricular (RV) leads. METHODS AND RESULTS: The European Lead Extraction ConTRolled Registry (ELECTRa) was analysed. Patients were divided into three groups; those with only AFix, only PFix, and combined Fix leads. Three outcomes were defined. Difficult extraction, complete radiological, and clinical success. Multivariate model was used to analyse the independent effect of Fix mechanism on these outcomes. The study included 2815 patients, 1456 (51.7%) with only AFix leads, 982 (34.9%) with only PFix leads, and 377 (13.4%) with combined Fix leads. Patients with AFix leads were younger with shorter lead dwelling time. Infection was the leading cause for TLE among the combined Fix group with lowest rates among AFix group. No difference in complications rates was noted between patients with only AFix vs. PFix leads. Overall, there were 1689 RA (1046 AFix and 643 PFix) and 2617 RV leads (1441 AFix and 1176 PFix). Multivariate model demonstrated that PFix is independently associated with more difficult extraction for both RA and RV leads, lower radiological success in the RA but has no effect on clinical success. CONCLUSION: Mechanism of Fix impact the ease of TLE of RA and RV leads and rates of complete radiological success in the RA but not clinical success. These findings should be considered during implantation and TLE procedures.

Published
2022
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21. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy:Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA)

Author

Glikson, Michael, Nielsen, Jens Cosedis, Kronborg, Mads Brix, Michowitz, Yoav, Auricchio, Angelo, Barbash, Israel Moshe, Barrabés, José A., Boriani, Giuseppe, Braunschweig, Frieder, Brignole, Michele, Burri, Haran, Coats, Andrew J. S., Deharo, Jean-Claude, Delgado, Victoria, Diller, Gerhard-Paul, Israel, Carsten W, Keren, Andre, Knops, Reinoud E., Kotecha, Dipak, Leclercq, Christophe, Merkely, Béla, Starck, Christoph, Thylén, Ingela, Tolosana, José Maria, Leyva, Francisco, Linde, Cecilia, Abdelhamid, Magdy, Aboyans, Victor, Arbelo, Elena, Asteggiano, Riccardo, Barón-Esquivias, Gonzalo, Bauersachs, Johann, Biffi, Mauro, Birgersdotter-Green, Ulrika, Bongiorni, Maria Grazia, Borger, Michael A, Čelutkienė, Jelena, Cikes, Maja, Daubert, Jean-Claude, Drossart, Inga, Ellenbogen, Kenneth, Elliott, Perry M, Fabritz, Larissa, Falk, Volkmar, Fauchier, Laurent, Fernández-Avilés, Francisco, Foldager, Dan, Gadler, Fredrik, De Vinuesa, Pastora Gallego Garcia, Gorenek, Bulent, Guerra, Jose M., Hermann Haugaa, Kristina, Hendriks, Jeroen, Kahan, Thomas, Katus, Hugo A, Konradi, Aleksandra, Koskinas, Konstantinos C, Law, Hannah, Lewis, Basil S, Linker, Nicholas John, Løchen, Maja-Lisa, Lumens, Joost, Mascherbauer, Julia, Mullens, Wilfried, Nagy, Klaudia Vivien, Prescott, Eva, Raatikainen, Pekka, Rakisheva, Amina, Reichlin, Tobias, Ricci, Renato Pietro, Shlyakhto, Evgeny, Sitges, Marta, Sousa-Uva, Miguel, Sutton, Richard, Suwalski, Piotr, Svendsen, Jesper Hastrup, Touyz, Rhian M, Van Gelder, Isabelle C, Vernooy, Kevin, Waltenberger, Johannes, Whinnett, Zachary, Witte, Klaus K., Glikson, Michael, Nielsen, Jens Cosedis, Kronborg, Mads Brix, Michowitz, Yoav, Auricchio, Angelo, Barbash, Israel Moshe, Barrabés, José A., Boriani, Giuseppe, Braunschweig, Frieder, Brignole, Michele, Burri, Haran, Coats, Andrew J. S., Deharo, Jean-Claude, Delgado, Victoria, Diller, Gerhard-Paul, Israel, Carsten W, Keren, Andre, Knops, Reinoud E., Kotecha, Dipak, Leclercq, Christophe, Merkely, Béla, Starck, Christoph, Thylén, Ingela, Tolosana, José Maria, Leyva, Francisco, Linde, Cecilia, Abdelhamid, Magdy, Aboyans, Victor, Arbelo, Elena, Asteggiano, Riccardo, Barón-Esquivias, Gonzalo, Bauersachs, Johann, Biffi, Mauro, Birgersdotter-Green, Ulrika, Bongiorni, Maria Grazia, Borger, Michael A, Čelutkienė, Jelena, Cikes, Maja, Daubert, Jean-Claude, Drossart, Inga, Ellenbogen, Kenneth, Elliott, Perry M, Fabritz, Larissa, Falk, Volkmar, Fauchier, Laurent, Fernández-Avilés, Francisco, Foldager, Dan, Gadler, Fredrik, De Vinuesa, Pastora Gallego Garcia, Gorenek, Bulent, Guerra, Jose M., Hermann Haugaa, Kristina, Hendriks, Jeroen, Kahan, Thomas, Katus, Hugo A, Konradi, Aleksandra, Koskinas, Konstantinos C, Law, Hannah, Lewis, Basil S, Linker, Nicholas John, Løchen, Maja-Lisa, Lumens, Joost, Mascherbauer, Julia, Mullens, Wilfried, Nagy, Klaudia Vivien, Prescott, Eva, Raatikainen, Pekka, Rakisheva, Amina, Reichlin, Tobias, Ricci, Renato Pietro, Shlyakhto, Evgeny, Sitges, Marta, Sousa-Uva, Miguel, Sutton, Richard, Suwalski, Piotr, Svendsen, Jesper Hastrup, Touyz, Rhian M, Van Gelder, Isabelle C, Vernooy, Kevin, Waltenberger, Johannes, Whinnett, Zachary, and Witte, Klaus K.

Published
2022

22. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA)

Author

Glikson, Michael, Nielsen, Jens Cosedis, Kronborg, Mads Brix, Michowitz, Yoav, Auricchio, Angelo, Barbash, Israel Moshe, Barrabes, Jose A., Boriani, Giuseppe, Braunschweig, Frieder, Brignole, Michele, Burri, Haran, Coats, Andrew J. S., Deharo, Jean-Claude, Delgado, Victoria, Diller, Gerhard-Paul, Israel, Carsten W., Keren, Andre, Knops, Reinoud E., Kotecha, Dipak, Leclercq, Christophe, Merkely, Bela, Starck, Christoph, Thylén, Ingela, Tolosana, Maria, Glikson, Michael, Nielsen, Jens Cosedis, Kronborg, Mads Brix, Michowitz, Yoav, Auricchio, Angelo, Barbash, Israel Moshe, Barrabes, Jose A., Boriani, Giuseppe, Braunschweig, Frieder, Brignole, Michele, Burri, Haran, Coats, Andrew J. S., Deharo, Jean-Claude, Delgado, Victoria, Diller, Gerhard-Paul, Israel, Carsten W., Keren, Andre, Knops, Reinoud E., Kotecha, Dipak, Leclercq, Christophe, Merkely, Bela, Starck, Christoph, Thylén, Ingela, and Tolosana, Maria

Abstract

n/a

Published
2022
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26. Corrigendum to: 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC): With the special contribution of the European Heart Rhythm Association (EHRA)

Author

Glikson, Michael, primary, Nielsen, Jens Cosedis, additional, Kronborg, Mads Brix, additional, Michowitz, Yoav, additional, Auricchio, Angelo, additional, Barbash, Israel Moshe, additional, Barrabés, José A, additional, Boriani, Giuseppe, additional, Braunschweig, Frieder, additional, Brignole, Michele, additional, Burri, Haran, additional, Coats, Andrew J S, additional, Deharo, Jean-Claude, additional, Delgado, Victoria, additional, Diller, Gerhard-Paul, additional, Israel, Carsten W, additional, Keren, Andre, additional, Knops, Reinoud E, additional, Kotecha, Dipak, additional, Leclercq, Christophe, additional, Merkely, Béla, additional, Starck, Christoph, additional, Thylén, Ingela, additional, and Tolosana, José Maria, additional

Published
2022
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28. Lead fixation mechanism impacts outcome of transvenous lead extraction: data from the European Lead Extraction ConTRolled Registry

Author

Levi, Nir, primary, Bongiorni, Maria Grazia, additional, Rav Acha, Moshe, additional, Tovia-Brodie, Oholi, additional, Kennergren, Charles, additional, Auricchio, Angelo, additional, Maggioni, Aldo Pietro, additional, Rinaldi, Christopher A, additional, Nof, Eyal, additional, Ilan, Michael, additional, Blomstrom-Lundqvist, Carina, additional, Deharo, Jean-Claude, additional, Leclercq, Christophe, additional, Glikson, Michael, additional, and Michowitz, Yoav, additional

Published
2021
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30. European Society of Cardiology Quality Indicators for the care and outcomes of cardiac pacing: developed by the Working Group for Cardiac Pacing Quality Indicators in collaboration with the European Heart Rhythm Association of the European Society of Cardiology

Author

Aktaa, Suleman, primary, Abdin, Amr, additional, Arbelo, Elena, additional, Burri, Haran, additional, Vernooy, Kevin, additional, Blomström-Lundqvist, Carina, additional, Boriani, Giuseppe, additional, Defaye, Pascal, additional, Deharo, Jean-Claude, additional, Drossart, Inga, additional, Foldager, Dan, additional, Gold, Michael R, additional, Johansen, Jens Brock, additional, Leyva, Francisco, additional, Linde, Cecilia, additional, Michowitz, Yoav, additional, Kronborg, Mads Brix, additional, Slotwiner, David, additional, Steen, Torkel, additional, Tolosana, José Maria, additional, Tzeis, Stylianos, additional, Varma, Niraj, additional, Glikson, Michael, additional, Nielsen, Jens Cosedis, additional, and Gale, Chris P, additional

Published
2021
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31. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy

Author

Glikson, Michael, primary, Nielsen, Jens Cosedis, additional, Kronborg, Mads Brix, additional, Michowitz, Yoav, additional, Auricchio, Angelo, additional, Barbash, Israel Moshe, additional, Barrabés, José A., additional, Boriani, Giuseppe, additional, Braunschweig, Frieder, additional, Brignole, Michele, additional, Burri, Haran, additional, Coats, Andrew J. S., additional, Deharo, Jean-Claude, additional, Delgado, Victoria, additional, Diller, Gerhard-Paul, additional, Israel, Carsten W., additional, Keren, Andre, additional, Knops, Reinoud E., additional, Kotecha, Dipak, additional, Leclercq, Christophe, additional, Merkely, Béla, additional, Starck, Christoph, additional, Thylén, Ingela, additional, Tolosana, José Maria, additional, Leyva, Francisco, additional, Linde, Cecilia, additional, Abdelhamid, Magdy, additional, Aboyans, Victor, additional, Arbelo, Elena, additional, Asteggiano, Riccardo, additional, Barón-Esquivias, Gonzalo, additional, Bauersachs, Johann, additional, Biffi, Mauro, additional, Birgersdotter-Green, Ulrika, additional, Bongiorni, Maria Grazia, additional, Borger, Michael A., additional, Čelutkienė, Jelena, additional, Cikes, Maja, additional, Daubert, Jean-Claude, additional, Drossart, Inga, additional, Ellenbogen, Kenneth, additional, Elliott, Perry M., additional, Fabritz, Larissa, additional, Falk, Volkmar, additional, Fauchier, Laurent, additional, Fernández-Avilés, Francisco, additional, Foldager, Dan, additional, Gadler, Fredrik, additional, De Vinuesa, Pastora Gallego Garcia, additional, Gorenek, Bulent, additional, Guerra, Jose M., additional, Hermann Haugaa, Kristina, additional, Hendriks, Jeroen, additional, Kahan, Thomas, additional, Katus, Hugo A., additional, Konradi, Aleksandra, additional, Koskinas, Konstantinos C., additional, Law, Hannah, additional, Lewis, Basil S., additional, Linker, Nicholas John, additional, Løchen, Maja-Lisa, additional, Lumens, Joost, additional, Mascherbauer, Julia, additional, Mullens, Wilfried, additional, Nagy, Klaudia Vivien, additional, Prescott, Eva, additional, Raatikainen, Pekka, additional, Rakisheva, Amina, additional, Reichlin, Tobias, additional, Ricci, Renato Pietro, additional, Shlyakhto, Evgeny, additional, Sitges, Marta, additional, Sousa-Uva, Miguel, additional, Sutton, Richard, additional, Suwalski, Piotr, additional, Svendsen, Jesper Hastrup, additional, Touyz, Rhian M., additional, Van Gelder, Isabelle C., additional, Vernooy, Kevin, additional, Waltenberger, Johannes, additional, Whinnett, Zachary, additional, and Witte, Klaus K., additional

Published
2021
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32. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA)

Author

Glikson, Michael, Nielsen, Jens Cosedis, Kronborg, Mads Brix, Michowitz, Yoav, Auricchio, Angelo, Barbash, Israel Moshe, Barrabes, Jose A., Boriani, Giuseppe, Braunschweig, Frieder, Brignole, Michele, Burri, Haran, Coats, Andrew J. S., Deharo, Jean-Claude, Delgado, Victoria, Diller, Gerhard-Paul, Israel, Carsten W., Keren, Andre, Knops, Reinoud E., Kotecha, Dipak, Leclercq, Christophe, Merkely, Bela, Starck, Christoph, Thylén, Ingela, Maria Tolosana, Jose, Glikson, Michael, Nielsen, Jens Cosedis, Kronborg, Mads Brix, Michowitz, Yoav, Auricchio, Angelo, Barbash, Israel Moshe, Barrabes, Jose A., Boriani, Giuseppe, Braunschweig, Frieder, Brignole, Michele, Burri, Haran, Coats, Andrew J. S., Deharo, Jean-Claude, Delgado, Victoria, Diller, Gerhard-Paul, Israel, Carsten W., Keren, Andre, Knops, Reinoud E., Kotecha, Dipak, Leclercq, Christophe, Merkely, Bela, Starck, Christoph, Thylén, Ingela, and Maria Tolosana, Jose

Abstract

n/a

Published
2021
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34. Out-of-hospital cardiac arrest due to idiopathic ventricular fibrillation in patients with normal electrocardiograms:results from a multicentre long-term registry

Author

Conte, Giulio, Belhassen, Bernard, Lambiase, Pier, Ciconte, Giuseppe, de Asmundis, Carlo, Arbelo, Elena, Schaer, Beat, Frontera, Antonio, Burri, Haran, Calo', Leonardo, Letsas, Kostantinos P., Leyva, Francisco, Porter, Bradley, Saenen, Johan, Zacà, Valerio, Berne, Paola, Ammann, Peter, Zardini, Marco, Luani, Blerim, Rordorf, Roberto, Sarquella Brugada, Georgia, Medeiros-Domingo, Argelia, Geller, Johann Christoph, de Potter, Tom, Stokke, Mathis K., Márquez, Manlio F., Michowitz, Yoav, Honarbakhsh, Shohreh, Conti, Manuel, Sticherling, Christian, Martino, Annamaria, Zegard, Abbasin, Özkartal, Tardu, Caputo, Maria Luce, Regoli, François, Braun-Dullaeus, Rüdiger C., Notarangelo, Francesca, Moccetti, Tiziano, Casu, Gavino, Rinaldi, Christopher A., Levinstein, Moises, Haugaa, Kristina H., Derval, Nicolas, Klersy, Catherine, Curti, Moreno, Pappone, Carlo, Heidbuchel, Hein, Brugada, Josép, Haïssaguerre, Michel, Brugada, Pedro, and Auricchio, Angelo

Abstract

AIMS : To define the clinical characteristics and long-term clinical outcomes of a large cohort of patients with idiopathic ventricular fibrillation (IVF) and normal 12-lead electrocardiograms (ECGs). METHODS AND RESULTS: Patients with ventricular fibrillation as the presenting rhythm, normal baseline, and follow-up ECGs with no signs of cardiac channelopathy including early repolarization or atrioventricular conduction abnormalities, and without structural heart disease were included in a registry. A total of 245 patients (median age: 38 years; males 59%) were recruited from 25 centres. An implantable cardioverter-defibrillator (ICD) was implanted in 226 patients (92%), while 18 patients (8%) were treated with drug therapy only. Over a median follow-up of 63 months (interquartile range: 25-110 months), 12 patients died (5%); in four of them (1.6%) the lethal event was of cardiac origin. Patients treated with antiarrhythmic drugs only had a higher rate of cardiovascular death compared to patients who received an ICD (16% vs. 0.4%, P = 0.001). Fifty-two patients (21%) experienced an arrhythmic recurrence. Age ≤16 years at the time of the first ventricular arrhythmia was the only predictor of arrhythmic recurrence on multivariable analysis [hazard ratio (HR) 0.41, 95% confidence interval (CI) 0.18-0.92; P = 0.03]. CONCLUSION : Patients with IVF and persistently normal ECGs frequently have arrhythmic recurrences, but a good prognosis when treated with an ICD. Children are a category of IVF patients at higher risk of arrhythmic recurrences.

Published
2019

41. Characterization and Management of Arrhythmic Events in Young Patients With Brugada Syndrome.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de cardiologie pédiatrique, Michowitz, Yoav, Milman, Anat, Andorin, Antoine, Sarquella-Brugada, Georgia, Gonzalez, Maria Cecilia, Gourraud, Jean-Baptiste, Conte, Giulio, Sacher, Frederic, Juang, Jimmy J M, Kim, Sung-Hwan, Leshem, Eran, Mabo, Philippe, Postema, Pieter G, Hochstadt, Aviram, Wijeyeratne, Yanushi D, Denjoy, Isabelle, Giustetto, Carla, Mizusawa, Yuka, Huang, Zhengrong, Jespersen, Camilla H, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Arbelo, Elena, Mazzanti, Andrea, Allocca, Giuseppe, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Priori, Silvia G, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Brugada, Josep, Kusano, Kengo F, Hirao, Kenzo, Calo, Leonardo, Takagi, Masahiko, Tfelt-Hansen, Jacob, Yan, Gan-Xin, Gaita, Fiorenzo, Leenhardt, Antoine, Behr, Elijah R, Wilde, Arthur A M, Nam, Gi-Byoung, Brugada, Pedro, Probst, Vincent, Belhassen, Bernard, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de cardiologie pédiatrique, Michowitz, Yoav, Milman, Anat, Andorin, Antoine, Sarquella-Brugada, Georgia, Gonzalez, Maria Cecilia, Gourraud, Jean-Baptiste, Conte, Giulio, Sacher, Frederic, Juang, Jimmy J M, Kim, Sung-Hwan, Leshem, Eran, Mabo, Philippe, Postema, Pieter G, Hochstadt, Aviram, Wijeyeratne, Yanushi D, Denjoy, Isabelle, Giustetto, Carla, Mizusawa, Yuka, Huang, Zhengrong, Jespersen, Camilla H, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Arbelo, Elena, Mazzanti, Andrea, Allocca, Giuseppe, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Priori, Silvia G, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Brugada, Josep, Kusano, Kengo F, Hirao, Kenzo, Calo, Leonardo, Takagi, Masahiko, Tfelt-Hansen, Jacob, Yan, Gan-Xin, Gaita, Fiorenzo, Leenhardt, Antoine, Behr, Elijah R, Wilde, Arthur A M, Nam, Gi-Byoung, Brugada, Pedro, Probst, Vincent, and Belhassen, Bernard

Abstract

BACKGROUND: Information on young patients with Brugada syndrome (BrS) and arrhythmic events (AEs) is limited. OBJECTIVES: The purpose of this study was to describe their characteristics and management as well as risk factors for AE recurrence. METHODS: A total of 57 patients (age ≤20 years), all with BrS and AEs, were divided into pediatric (age ≤12 years; n = 26) and adolescents (age 13 to 20 years; n = 31). RESULTS: Patients' median age at time of first AE was 14 years, with a majority of males (74%), Caucasians (70%), and probands (79%) who presented as aborted cardiac arrest (84%). A significant proportion of patients (28%) exhibited fever-related AE. Family history of sudden cardiac death (SCD), prior syncope, spontaneous type 1 Brugada electrocardiogram (ECG), inducible ventricular fibrillation at electrophysiological study, and SCN5A mutations were present in 26%, 49%, 65%, 28%, and 58% of patients, respectively. The pediatric group differed from the adolescents, with a greater proportion of females, Caucasians, fever-related AEs, and spontaneous type-1 ECG. During follow-up, 68% of pediatric and 64% of adolescents had recurrent AE, with median time of 9.9 and 27.0 months, respectively. Approximately one-third of recurrent AEs occurred on quinidine therapy, and among the pediatric group, 60% of recurrent AEs were fever-related. Risk factors for recurrent AE included sinus node dysfunction, atrial arrhythmias, intraventricular conduction delay, or large S-wave on ECG lead I in the pediatric group and the presence of SCN5A mutation among adolescents. CONCLUSIONS: Young BrS patients with AE represent a very arrhythmogenic group. Current management after first arrhythmia episode is associated with high recurrence rate. Alternative therapies, besides defibrillator implantation, should be considered.

Published
2019

42. Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator:data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Author

Milman, Anat, Hochstadt, Aviram, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Conte, Giulio, Arbelo, Elena, Kamakura, Tsukasa, Aiba, Takeshi, Napolitano, Carlo, Giustetto, Carla, Denjoy, Isabelle, Juang, Jimmy J M, Maeda, Shingo, Takahashi, Yoshihide, Leshem, Eran, Michowitz, Yoav, Rahkovich, Michael, Jespersen, Camilla H, Wijeyeratne, Yanushi D, Champagne, Jean, Calo, Leonardo, Huang, Zhengrong, Mizusawa, Yuka, Postema, Pieter G, Brugada, Ramon, Wilde, Arthur A M, Yan, Gan-Xin, Behr, Elijah R, Tfelt-Hansen, Jacob, Hirao, Kenzo, Veltmann, Christian, Leenhardt, Antoine, Corrado, Domenico, Gaita, Fiorenzo, Priori, Silvia G, Kusano, Kengo F, Takagi, Masahiko, Delise, Pietro, Brugada, Josep, Brugada, Pedro, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Hochstadt, Aviram, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Conte, Giulio, Arbelo, Elena, Kamakura, Tsukasa, Aiba, Takeshi, Napolitano, Carlo, Giustetto, Carla, Denjoy, Isabelle, Juang, Jimmy J M, Maeda, Shingo, Takahashi, Yoshihide, Leshem, Eran, Michowitz, Yoav, Rahkovich, Michael, Jespersen, Camilla H, Wijeyeratne, Yanushi D, Champagne, Jean, Calo, Leonardo, Huang, Zhengrong, Mizusawa, Yuka, Postema, Pieter G, Brugada, Ramon, Wilde, Arthur A M, Yan, Gan-Xin, Behr, Elijah R, Tfelt-Hansen, Jacob, Hirao, Kenzo, Veltmann, Christian, Leenhardt, Antoine, Corrado, Domenico, Gaita, Fiorenzo, Priori, Silvia G, Kusano, Kengo F, Takagi, Masahiko, Delise, Pietro, Brugada, Josep, Brugada, Pedro, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

Aims: Data on predictors of time-to-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD's are scarce.Methods and results: SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-to-first appropriate ICD discharge regarding patients' characteristics. Multivariate logistic regression models were utilized to identify which parameters predicted time to arrhythmia ≤5 years. The median time-to-first appropriate ICD therapy was 24.8 ± 2.8 months. A shorter time was observed in patients from Asian ethnicity (P < 0.05), those with syncope (P = 0.001), and those with Class IIa indication for ICD (P = 0.001). A longer time was associated with a positive family history of sudden cardiac death (P < 0.05). Multivariate Cox regression revealed shorter time-to-ICD therapy in patients with syncope [odds ratio (OR) 1.65, P = 0.001]. In 193 patients (76.6%), therapy was delivered during the first 5 years. Factors associated with this time were syncope (OR 0.36, P = 0.001), spontaneous Type 1 Brugada electrocardiogram (ECG) (OR 0.5, P < 0.05), and Class IIa indication (OR 0.38, P < 0.01) as opposed to Class IIb (OR 2.41, P < 0.01). A near-significant trend for female gender was also noted (OR 0.13, P = 0.052). Two score models for prediction of <5 years to shock were built.Conclusion: First appropriate therapy in BrS patients with prophylactic ICD's occurred during the first 5 years in 76.6% of patients. Syncope and spontaneous Type 1 Brugada ECG correlated with a shorter time to ICD therapy.

Published
2019

43. Ethnic differences in patients with Brugada syndrome and arrhythmic events:New insights from Survey on Arrhythmic Events in Brugada Syndrome

Author

Milman, Anat, Andorin, Antoine, Postema, Pieter G., Gourraud, Jean Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Juang, Jimmy J.M., Leshem, Eran, Michowitz, Yoav, Fogelman, Rami, Hochstadt, Aviram, Mizusawa, Yuka, Giustetto, Carla, Arbelo, Elena, Huang, Zhengrong, Corrado, Domenico, Delise, Pietro, Allocca, Giuseppe, Takagi, Masahiko, Wijeyeratne, Yanushi D., Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Jespersen, Camilla H., Tfelt-Hansen, Jacob, Veltmann, Christian, Priori, Silvia G., Behr, Elijah R., Yan, Gan Xin, Brugada, Josep, Gaita, Fiorenzo, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Andorin, Antoine, Postema, Pieter G., Gourraud, Jean Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Juang, Jimmy J.M., Leshem, Eran, Michowitz, Yoav, Fogelman, Rami, Hochstadt, Aviram, Mizusawa, Yuka, Giustetto, Carla, Arbelo, Elena, Huang, Zhengrong, Corrado, Domenico, Delise, Pietro, Allocca, Giuseppe, Takagi, Masahiko, Wijeyeratne, Yanushi D., Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Jespersen, Camilla H., Tfelt-Hansen, Jacob, Veltmann, Christian, Priori, Silvia G., Behr, Elijah R., Yan, Gan Xin, Brugada, Josep, Gaita, Fiorenzo, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

Background: There is limited information on ethnic differences between patients with Brugada syndrome (BrS) and arrhythmic events (AEs). Objective: The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between white and Asian patients with BrS and AEs. Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter survey from Western and Asian countries, gathering 678 patients with BrS and first documented AE. After excluding patients with other (n = 14 [2.1%]) or unknown (n = 30 [4.4%]) ethnicity, 364 (53.7%) whites and 270 (39.8%) Asians comprised the study group. Results: There was no difference in AE age onset (41.3 ± 16.1 years in whites vs 43.3 ± 12.3 years in Asians; P = .285). Higher proportions of whites were observed in pediatric and elderly populations. Asians were predominantly men (98.1% vs 85.7% in whites; P < .001) and frequently presented with aborted cardiac arrest (71.1% vs 56%; P < .001). Asians tended to display more spontaneous type 1 BrS-ECG pattern (71.5% vs 64.3%; P = .068). A family history of sudden cardiac death was noted more in whites (29.1% vs 11.5%; P < .001), with a higher rate of SCN5A mutation carriers (40.1% vs 13.2% in Asians; P < .001), as well as more fever-related AEs (8.5% vs 2.9%; P = .011). No difference was observed between the 2 groups regarding history of syncope and ventricular arrhythmia inducibility. Conclusion: There are important differences between Asian and white patients with BrS. Asian patients present almost exclusively as male adults, more often with aborted cardiac arrest and spontaneous type 1 BrS-ECG. However, they have less family history of sudden cardiac death and markedly lower SCN5A mutation rates. The striking difference in SCN5A mutation rates should be tested in future studies.

Published
2019

44. Profile of Brugada Syndrome Patients Presenting with Their First Documented Arrhythmic Event. Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Author

Milman, Anat, Andorin, Antoine, Gourraud, Jean-Baptiste, Postema, Pieter G, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Juang, Jimmy Jm, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Sarquella-Brugada, Georgia, Leshem, Eran, Rahkovich, Michael, Hochstadt, Aviram, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D, Napolitano, Carlo, Michowitz, Yoav, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A. M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, ACS - Amsterdam Cardiovascular Sciences, Cardiology, Other departments, and ACS - Heart failure & arrhythmias

Subjects
arrhythmic risk stratification, ICD, electrophysiologic study, genetics, sudden cardiac death
Abstract

BACKGROUND: Detailed information on the profile of Brugada syndrome (BrS) patients presenting their first arrhythmic event (AE) after prophylactic implantation of a cardioverter defibrillator (ICD) is limited. OBJECTIVES: 1) To compare clinical, electrocardiographic, electrophysiologic and genetic profiles of patients who exhibited their first documented AE as aborted cardiac arrest (CA) (group A) with those in whom the AE was documented after prophylactic ICD implantation (group B); 2) To characterize group B patients' profile using the Class II indications for ICD implantation established by HRS/EHRA/APHRS Expert Consensus Statement in 2013. METHODS: A survey of 23 centers from 10 Western and 4 Asian countries enabled data collection of 678 BrS patients with AE (group A, n=426; group B, n=252). RESULTS: First AE occurred in group B patients 6.7 years later than in group A (46.1+ 13.3 vs. 39.4+15.1, P

Published
2018

45. Out-of-hospital cardiac arrest due to idiopathic ventricular fibrillation in patients with normal electrocardiograms: results from a multicentre long-term registry

Author

Conte, Giulio, primary, Belhassen, Bernard, additional, Lambiase, Pier, additional, Ciconte, Giuseppe, additional, de Asmundis, Carlo, additional, Arbelo, Elena, additional, Schaer, Beat, additional, Frontera, Antonio, additional, Burri, Haran, additional, Calo’, Leonardo, additional, Letsas, Kostantinos P, additional, Leyva, Francisco, additional, Porter, Bradley, additional, Saenen, Johan, additional, Zacà, Valerio, additional, Berne, Paola, additional, Ammann, Peter, additional, Zardini, Marco, additional, Luani, Blerim, additional, Rordorf, Roberto, additional, Sarquella Brugada, Georgia, additional, Medeiros-Domingo, Argelia, additional, Geller, Johann-Christoph, additional, de Potter, Tom, additional, Stokke, Mathis K, additional, Márquez, Manlio F, additional, Michowitz, Yoav, additional, Honarbakhsh, Shohreh, additional, Conti, Manuel, additional, Sticherling, Christian, additional, Martino, Annamaria, additional, Zegard, Abbasin, additional, Özkartal, Tardu, additional, Caputo, Maria Luce, additional, Regoli, François, additional, Braun-Dullaeus, Rüdiger C, additional, Notarangelo, Francesca, additional, Moccetti, Tiziano, additional, Casu, Gavino, additional, Rinaldi, Christopher A, additional, Levinstein, Moises, additional, Haugaa, Kristina H, additional, Derval, Nicolas, additional, Klersy, Catherine, additional, Curti, Moreno, additional, Pappone, Carlo, additional, Heidbuchel, Hein, additional, Brugada, Josép, additional, Haïssaguerre, Michel, additional, Brugada, Pedro, additional, and Auricchio, Angelo, additional

Published
2019
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46. Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Author

Milman, Anat, primary, Hochstadt, Aviram, additional, Andorin, Antoine, additional, Gourraud, Jean-Baptiste, additional, Sacher, Frederic, additional, Mabo, Philippe, additional, Kim, Sung-Hwan, additional, Conte, Giulio, additional, Arbelo, Elena, additional, Kamakura, Tsukasa, additional, Aiba, Takeshi, additional, Napolitano, Carlo, additional, Giustetto, Carla, additional, Denjoy, Isabelle, additional, Juang, Jimmy J M, additional, Maeda, Shingo, additional, Takahashi, Yoshihide, additional, Leshem, Eran, additional, Michowitz, Yoav, additional, Rahkovich, Michael, additional, Jespersen, Camilla H, additional, Wijeyeratne, Yanushi D, additional, Champagne, Jean, additional, Calo, Leonardo, additional, Huang, Zhengrong, additional, Mizusawa, Yuka, additional, Postema, Pieter G, additional, Brugada, Ramon, additional, Wilde, Arthur A M, additional, Yan, Gan-Xin, additional, Behr, Elijah R, additional, Tfelt-Hansen, Jacob, additional, Hirao, Kenzo, additional, Veltmann, Christian, additional, Leenhardt, Antoine, additional, Corrado, Domenico, additional, Gaita, Fiorenzo, additional, Priori, Silvia G, additional, Kusano, Kengo F, additional, Takagi, Masahiko, additional, Delise, Pietro, additional, Brugada, Josep, additional, Brugada, Pedro, additional, Nam, Gi-Byoung, additional, Probst, Vincent, additional, and Belhassen, Bernard, additional

Published
2018
Full Text
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47. Profile of patients with Brugada syndrome presenting with their first documented arrhythmic event:Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Author

Milman, Anat, Andorin, Antoine, Gourraud, Jean Baptiste, Postema, Pieter G., Sacher, Frederic, Mabo, Philippe, Kim, Sung Hwan, Juang, Jimmy J.M., Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Sarquella-Brugada, Georgia, Leshem, Eran, Rahkovich, Michael, Hochstadt, Aviram, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D., Napolitano, Carlo, Michowitz, Yoav, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Tfelt-Hansen, Jacob, Priori, Silvia G., Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Andorin, Antoine, Gourraud, Jean Baptiste, Postema, Pieter G., Sacher, Frederic, Mabo, Philippe, Kim, Sung Hwan, Juang, Jimmy J.M., Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Sarquella-Brugada, Georgia, Leshem, Eran, Rahkovich, Michael, Hochstadt, Aviram, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D., Napolitano, Carlo, Michowitz, Yoav, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Tfelt-Hansen, Jacob, Priori, Silvia G., Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

BACKGROUND: Detailed information on the profile of patients with Brugada syndrome (BrS) presenting their first arrhythmic event (AE) after prophylactic implantation of an implantable cardioverter-defibrillator (ICD) is limited.OBJECTIVES: The objectives of this study were (1) to compare clinical, electrocardiographic, electrophysiologic, and genetic profiles of patients who exhibited their first documented AE as aborted cardiac arrest (group A) with profiles of those in whom the AE was documented after prophylactic ICD implantation (group B) and (2) to characterize group B patients' profile using the class II indications for ICD implantation established by HRS/EHRA/APHRS expert consensus statement in 2013.METHODS: A survey of 23 centers from 10 Western and 4 Asian countries enabled data collection of 678 patients with BrS who exhibited their AE (group A, n = 426; group B, n = 252).RESULTS: The first AE occurred in group B patients 6.7 years later than in group A (mean age 46.1 ± 13.3 years vs 39.4 ± 15.1 years; P < .001). Group B patients had a higher incidence of family history of sudden cardiac death and SCN5A mutations. Of the 252 group B patients, 189 (75%) complied with the HRS/EHRA/APHRS indications whereas the remaining 63 (25%) did not.CONCLUSION: Patients with BrS with the first AE documented after prophylactic ICD implantation exhibited their AE at a later age with a higher incidence of positive family history of sudden cardiac death and SCN5A mutations as compared with those presenting with aborted cardiac arrest. Only 75% of patients who exhibited an AE after receiving a prophylactic ICD complied with the 2013 class II indications, suggesting that efforts are still required for improving risk stratification.

Published
2018

48. Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome

Author

Michowitz, Yoav, Milman, Anat, Sarquella-Brugada, Georgia, Andorin, Antoine, Champagne, Jean, Postema, Pieter G., Casado-Arroyo, Ruben, Leshem, Eran, Juang, Jimmy J.M., Giustetto, Carla, Tfelt-Hansen, Jacob, Wijeyeratne, Yanushi D., Veltmann, Christian, Corrado, Domenico, Kim, Sung Hwan, Delise, Pietro, Maeda, Shingo, Gourraud, Jean Baptiste, Sacher, Frederic, Mabo, Philippe, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Hochstadt, Aviram, Mizusawa, Yuka, Rahkovich, Michael, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Napolitano, Carlo, Brugada, Ramon, Calo, Leonardo, Priori, Silvia G., Takagi, Masahiko, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, Belhassen, Bernard, Michowitz, Yoav, Milman, Anat, Sarquella-Brugada, Georgia, Andorin, Antoine, Champagne, Jean, Postema, Pieter G., Casado-Arroyo, Ruben, Leshem, Eran, Juang, Jimmy J.M., Giustetto, Carla, Tfelt-Hansen, Jacob, Wijeyeratne, Yanushi D., Veltmann, Christian, Corrado, Domenico, Kim, Sung Hwan, Delise, Pietro, Maeda, Shingo, Gourraud, Jean Baptiste, Sacher, Frederic, Mabo, Philippe, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Hochstadt, Aviram, Mizusawa, Yuka, Rahkovich, Michael, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Napolitano, Carlo, Brugada, Ramon, Calo, Leonardo, Priori, Silvia G., Takagi, Masahiko, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

Background: The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series. Objective: The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS. Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n = 252). Results: In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 ± 24 years (range 0.3–76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0–5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years. Conclusion: The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever.

Published
2018

49. Gender differences in patients with Brugada syndrome and arrhythmic events:Data from a survey on arrhythmic events in 678 patients

Author

Milman, Anat, Gourraud, Jean Baptiste, Andorin, Antoine, Postema, Pieter G., Sacher, Frederic, Mabo, Philippe, Conte, Giulio, Giustetto, Carla, Sarquella-Brugada, Georgia, Hochstadt, Aviram, Kim, Sung Hwan, Juang, Jimmy J.M., Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Leshem, Eran, Michowitz, Yoav, Rahkovich, Michael, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Wijeyeratne, Yanushi D., Napolitano, Carlo, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Tfelt-Hansen, Jacob, Priori, Silvia G., Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Gourraud, Jean Baptiste, Andorin, Antoine, Postema, Pieter G., Sacher, Frederic, Mabo, Philippe, Conte, Giulio, Giustetto, Carla, Sarquella-Brugada, Georgia, Hochstadt, Aviram, Kim, Sung Hwan, Juang, Jimmy J.M., Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Leshem, Eran, Michowitz, Yoav, Rahkovich, Michael, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Wijeyeratne, Yanushi D., Napolitano, Carlo, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Tfelt-Hansen, Jacob, Priori, Silvia G., Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

Background: There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). Objective: The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and females in patients with BrS with their first AE. Methods: The multicenter Survey on Arrhythmic Events in BRUgada Syndrome collected data on the first AE in 678 patients with BrS including 619 males (91.3%) and 59 females (8.7%) aged 0.27–84 years (mean age 42.5 ± 14.1 years) at the time of AE occurrence. Results: After excluding pediatric patients, it was found that females were older than males (49.5 ± 14.4 years vs 43 ± 12.7 years, respectively; P =.001). Higher proportions of females were observed in the pediatric and elderly populations. In Asians, the male to female ratio for AEs was ≈9-fold higher than that in White. Spontaneous type 1 BrS ECG was associated with an earlier onset of AEs in pediatric females. A similar prevalence (≈65%) of spontaneous type 1 BrS ECG was present in males and females above the age of 60 years. Females less frequently showed spontaneous type 1 BrS ECG (41% vs 69%; P <.001) or arrhythmia inducibility at electrophysiology study (36% vs 66%; P <.001). An SCN5A mutation was more frequently found in females (48% vs 28% in males; P =.007). Conclusion: This study confirms that female patients with BrS are much rarer, display less type 1 Brugada ECG, and exhibit lower inducibility rates than do males. It shows for the first time that female patients with BrS with AE have higher SCN5A mutation rates as well as the relationship between gender vs age at the onset of AEs and ethnicity.

Published
2018

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