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PURPOSE: Neurofibromatosis type 2 (NF2) and schwannomatosis (SWN) are genetically distinct tumor predisposition syndromes with overlapping phenotypes. We sought to update the diagnostic criteria for NF2 and SWN by incorporating recent advances in genetics, ophthalmology, neuropathology, and neuroimaging. METHODS: We used a multistep process, beginning with a Delphi method involving global disease experts and subsequently involving non-neurofibromatosis clinical experts, patients, and foundations/patient advocacy groups. RESULTS: We reached consensus on the minimal clinical and genetic criteria for diagnosing NF2 and SWN. These criteria incorporate mosaic forms of these conditions. In addition, we recommend updated nomenclature for these disorders to emphasize their phenotypic overlap and to minimize misdiagnosis with neurofibromatosis type 1. CONCLUSION: The updated criteria for NF2 and SWN incorporate clinical features and genetic testing, with a focus on using molecular data to differentiate the 2 conditions. It is likely that continued refinement of these new criteria will be necessary as investigators study the diagnostic properties of the revised criteria and identify new genes associated with SWN. In the revised nomenclature, the term "neurofibromatosis 2" has been retired to improve diagnostic specificity. ispartof: GENETICS IN MEDICINE vol:24 issue:9 pages:1967-1977 ispartof: location:United States status: published

Although polling is not irredeemably broken, changes in technology and society create challenges that, if not addressed well, can threaten the quality of election polls and other important surveys on topics such as the economy. This essay describes some of these challenges and recommends remediations to protect the integrity of all kinds of survey research, including election polls. These 12 recommendations specify ways that survey researchers, and those who use polls and other public-oriented surveys, can increase the accuracy and trustworthiness of their data and analyses. Many of these recommendations align practice with the scientific norms of transparency, clarity, and self-correction. The transparency recommendations focus on improving disclosure of factors that affect the nature and quality of survey data. The clarity recommendations call for more precise use of terms such as “representative sample” and clear description of survey attributes that can affect accuracy. The recommendation about correcting the record urges the creation of a publicly available, professionally curated archive of identified technical problems and their remedies. The paper also calls for development of better benchmarks and for additional research on the effects of panel conditioning. Finally, the authors suggest ways to help people who want to use or learn from survey research understand the strengths and limitations of surveys and distinguish legitimate and problematic uses of these methods.

Meningeal solitary fibrous tumor (SFT) is a rare tumor with high propensity to recur and metastasize, even late in the course of disease. The WHO 2021 classification of CNS tumors divides SFT in 3 grades, based on mitotic index and necrosis. We re-examined our cohort of 126 patients (57 F, 69 M; mean age 53.0 years) with SFT, confirmed by STAT6 nuclear positivity and/or NAB2::STAT6 fusion, with extended follow-up (median 7.6 years; range 4 days-26.6 years). Tumors included 76 grade 1, 36 grade 2 and 14 grade 3 according to 2021 WHO criteria, evaluated at primary resection (n=90), recurrence (n=35), or metastasis (n=1). Fifty-six patients had one or more post-surgical events, the earliest event being local recurrence (n=41) or metastasis (n=15). Forty patients died (29 of disease; 9 of other causes; 2 unknown). Overall survival (OS), and progression-free survival (PFS, recurrence and/or metastasis) from time of primary resection (n=90) were not significantly associated with grade; however, risk of metastasis differed significantly (5-year estimates: 4.1%, 15.3%, and 37.8% for grades 1, 2, and 3 SFT, respectively; p=0.005). NAB2::STAT6 fusion status was known in 101 cases (51 = ex5-7-ex16-17, 26 = ex4_ex2-3; 12 = ex2-3_exANY/other and 12 =no fusion). Disease specific 5-year survival in primary tumors with molecular data (n = 75) was 80.0% in patients whose tumors harbored ex5-7_ex16-17 compared to 93.3% in all others combined (p=0.014). Targeted TERT promoter mutation testing was performed in 98 patients, revealing patients with tumors lacking TERT promoter mutation (n = 88) were younger at time of surgery than those harboring a mutation (n=10; p = 0.022), and none with a mutation harboring concurrent ex5-7_ex16-17 fusion (p = 0.0009). In summary, WHO 2021 grade is associated with risk of metastasis. Patients whose tumors harbor ex5-7_ex16-17 fusion have a higher risk of dying from the disease.

Modern science and engineering computing environments often feature storage systems of different types, from parallel file systems in high-performance computing centers to object stores operated by cloud providers. To enable easy, reliable, secure, and performant data exchange among these different systems, we propose Connector, a plug-able data access architecture for diverse, distributed storage. By abstracting low-level storage system details, this abstraction permits a managed data transfer service (Globus, in our case) to interact with a large and easily extended set of storage systems. Equally important, it supports third-party transfers: that is, direct data transfers from source to destination that are initiated by a third-party client but do not engage that third party in the data path. The abstraction also enables management of transfers for performance optimization, error handling, and end-to-end integrity. We present the Connector design, describe implementations for different storage services, evaluate tradeoffs inherent in managed vs. direct transfers, motivate recommended deployment options, and propose a model-based method that allows for easy characterization of performance in different contexts without exhaustive benchmarking.

Norian–Rhaetian reef carbonates are exposed in several localities in Taurus Mountains. They predominately contain hypercalcified sponges, followed by scleractinian corals and other less numerous organisms. A coherent Norian–Rhaetian reef structure is exposed near the small town of Saklıkent, west of Antalya. Foraminifers occur in reef carbonates of Saklıkent by numerous genera as shown in this paper. Two species —Siculocosta tauricaandSiculocosta sadati— are described as new. The foraminiferal association of Saklıkent is similar or almost identical to the associations known from the Norian–Rhaetian reefs of Sicily, Northern Calcareous Alps, and Greece but shows less similarity to the foraminiferal association from the Apennines, Italy. The most abundant foraminifers are milioliporoids, particularly galeanellids and cucurbitids. Some sessile and agglutinated foraminifers, includingAlpinophragmium perforatumFlügel, which mostly occurs abundantly in the Norian–Rhaetian reef carbonates, could not be found in the Saklıkent reef. This association of foraminifera is reported for the first time from a Norian–Rhaetian reef in the Taurus Mountains of Turkey.

Background Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes.Methods We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18-85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR) 25-75 mL/min per 1.73 m(2) of body surface area, and a urine albumin-to-creatinine ratio (UACR) of 300-5000 mg/g who had received maximum labelled or tolerated renin-angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0.75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders) were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0.75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for >= 30 days) or end-stage kidney disease (eGFR = 90 days, chronic dialysis for >= 90 days, kidney transplantation, or death from kidney failure) in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials. gov, number NCT01858532.Findings Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325) or placebo group (n=1323). Median follow-up was 2.2 years (IQR 1.4-2.9). 79 (6.0%) of 1325 patients in the atrasentan group and 105 (7.9%) of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR] 0.65 [95% CI 0.49-0.88]; p=0.0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3.5%) of 1325 patients in the atrasentan group and 34 (2.6%) of 1323 patients in the placebo group (HR 1.33 [95% CI 0.85-2.07]; p=0.208). 58 (4.4%) patients in the atrasentan group and 52 (3.9%) in the placebo group died (HR 1.09 [95% CI 0.75-1.59]; p=0.65).Interpretation Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Copyright (C) 2019 Elsevier Ltd. All rights reserved.

Jahnke, H. N., & Hefendehl-Hebeker, L. (Eds.). (2019). Traditions in German-speaking mathematics education reserach (ICME-13 Monographs). Cham: Spinger Open, , pp. 61-89., Considering mathematics education as a DESIGN SCIENCE has strong roots in Germany. E. Ch. Wittmann in particular contributed to the establishment of this approach. From a DESIGN SCIENCE perspective, substantial learning environments play a crucial role. They comprise mathematical tasks which are connected in an operative way, indicative of a specific epistemological structure. In such substantial learning environments, students are actively immersed in learning mathematics, and the learning environments allow for the pursuit of individual and differentiated learning processes. In this chapter, we first address the scope of Design Science and pay attention to characteristics of the learning environments and how teaching experiments can be conducted. We then focus on key ideas and their role as a design principle. In the next section, we provide a comprehensive example of designing a learning environment. Lastly, we shift our attention to the Design Research approach, which complements designing substantial learning environments by empirically studying the initiated learning processes to gain evidence for both theoretical considerations and design principles.

Adequate fresh water availability is an important factor for human security in many parts of the world. In transboundary river basins, decreased water supply due to local environmental change and global climate change and increased water demand due to growing populations and continued economic development can aggravate water scarcity. Contrary to the claim that water scarcity may result in an increased risk of armed conflict, there is no simple relationship between freshwater availability and violent conflict. Other crucial factors need to be taken into consideration that also directly influence resource availability and personal human well-being. In this review, we assess the scientific literature on conflict and cooperation in transboundary river systems. Most international river basins are already jointly managed by the riparians, but successful management in times of climate change necessitates the inclusion of more factors besides mere allocation schemes. On the basis of a substantial body of literature on the management of transboundary watersheds, an analytical framework of the water-security nexus is developed that integrates the physical and socioeconomic pathways connecting water availability with conflict or cooperation. This framework is subsequently applied to two transboundary river basins—the Nile River and the Syr Darya/Amu Darya—as they represent two world regions that could become future water hot spots. An improved understanding of the developments leading to water conflicts and their interaction can help to successfully reduce the risk of water conflicts in these regions and to move toward increased cooperation among the riparians of transboundary river systems. WIREs Water 2016, 3:495–515. doi: 10.1002/wat2.1151. This article is categorized under: Engineering Water > Planning Water Science of Water > Water and Environmental Change Human Water > Water Governance.

Deterministic model updating is now a mature technology widely applied to large-scale industrial structures. It is concerned with the calibration of the parameters of a single model based on one set of test data. It is, of course, well known that different analysts produce different finite element models, make different physics-based assumptions, and parameterize their models differently. Also, tests carried out on the same structure, by different operatives, at different times, under different ambient conditions produce different results. There is no unique model and no unique data. Therefore, model updating needs to take account of modeling and test-data variability. Much emphasis is now placed on what has become known as stochastic model updating where data are available from multiple nominally identical test structures. In this paper two currently prominent stochastic model updating techniques (sensitivity-based updating and Bayesian model updating) are described and applied to the DLR AIRMOD structure.

Verglichen mit den Risiken und Konflikten des fossil-nuklearen Zeitalters erscheinen die erneuerbaren Energien in einem überwiegend positiven Licht. Allerdings schafft die Transformation zu einer kohlenstoffarmen Energieversorgung neue Energielandschaften, die einen hohen Bedarf an Landflächen mit sich bringen – was ebenfalls Energiekonflikte provozieren kann. Um derartige Konflikte zu mindern und die Akzeptanz der Bevölkerung zu gewinnen, kann Technikfolgenabschätzung einen Beitrag leisten, wenn sie sich auf räumliche agentenbasierte Modelle stützt. Diese Modelle repräsentieren die Entscheidungen von Stakeholdern über Energiealternativen, deren dynamische Interaktionen sowie daraus resultierende Landnutzungsoptionen und Energiepfade. Als Fallstudie dient Norddeutschland, wo Landwirte und Gemeinden als lokale Akteure der Energiewende agieren. The risks and conflicts of the fossil-nuclear age are in contrast to the effects of renewable energies which appear in a largely positive light. However, the transformation towards a low-carbon energy supply creates new energy landscapes with a high demand for suitable land areas – which may also provoke energy conflicts. Technology assessment can contribute to reducing such energy conflicts and increasing public acceptance by using spatial agent-based models that represent dynamic decisions and interactions of stakeholders regarding energy alternatives and land-use options. Northern Germany serves as a case study region where farmers and communities are local actors of the energy transition.

In einer qualitativen Interviewstudie wird untersucht, wie padagogische Fachkrafte mathematische Lerngelegenheiten gestalten und welche Uberzeugungen zum mathematischen Lernen im Kindergarten dahinter sichtbar werden. Die Ergebnisse zeigen, dass fur die padagogischen Fachkrafte das Interesse der Kinder ein wichtiger Bezugspunkt fur die Gestaltung mathematischer Lerngelegenheiten ist: Als Bedingung fur die Planung und Vorbereitung von mathematischen Lerngelegenheiten (Warten auf das Interesse der Kinder), als Bedingung fur die Teilnahme der Kinder an mathematischen Lerngelegenheiten (Teilnahme in Abhangigkeit von Interesse) oder als Ziel und Merkmal der Gestaltung mathematischer Lerngelegenheiten (Wecken von Interesse).

This article presents the application of finite-element fuzzy model updating to the DLR AIRMOD structure. The proposed approach is initially demonstrated on a simulated mass-spring system with three degrees of freedom. Considering the effect of the assembly process on variability measurements, modal tests were carried out for the repeatedly disassembled and reassembled DLR AIRMOD structure. The histograms of the measured data attributed to the uncertainty of the structural components in terms of mass and stiffness are utilised to obtain the membership functions of the chosen fuzzy outputs and to determine the updated membership functions of the uncertain input parameters represented by fuzzy variables. In this regard, a fuzzy parameter is introduced to represent a set of interval parameters through the membership function, and a meta model (kriging, in this work) is used to speed up the updating. The use of non-probabilistic models, i.e. interval and fuzzy models, for updating models with uncertainties is often more practical when the large quantities of test data that are necessary for probabilistic model updating are unavailable.

Upper Triassic Norian reef boulders, exposed in a locality in the Central Taurids, southern Turkey, yielded a high number of hypercalcified sponges, including Sphinctozoans, Inozoans, Spongiomorphids, and Chaetetids. The reef boulders are exposed near the fountain Tavuk Çeşme, located at the road leading from the town of Aksu to Yenişarbademli. Geologically this locality belongs to the Anamas Akseki Autochthon. In this paper a new inozoan sponge, Bicoelia corticifera nov. sp., is described from Tavuk Çeşme. It is a cylindrical and unbranched sponge, found in several thin sections. The sponge is characterized by 2 axial spongocoels, and the sponge wall is composed of fine reticulate fiber skeleton and a distinct outer wall. Usually several specimens grow closely side by side.

What: An international group of scientists reviewed the potential consequences of climate engineering and provided a first mapping of the problem landscape, identifying knowledge gaps and emerging research questions. When: 10–11 November 2011 Where: Hamburg, Germany T here is a growing discussion about the intentional manipulation and control of the climate system—known as “geoengineering” or “climate engineering.” This is in part due to some scientists and political authorities considering geoengineering as a necessary “plan B” option for a “global last resort” to counter catastrophic climate change. While research on climate engineering is already attracting resources and interest, there is a lack of understanding of the potential consequences, in particular for peace and security. A workshop1 held at the University of Hamburg, Germany, in the fall of 2011 examined these issues to identify gaps in our understanding of geoengineering and to address emerging questions (the conference program is available at http://clisec.zmaw.de /Conference-program.1929.0.html). In the opening keynote speech, an overview of the different possibilities for geoengineering Earth’s climate generally identified two fundamental categories: carbon dioxide (CO2) removal (CDR) and solar radiation management (SRM). The overarching goal of all measures is to offset climate change. However, it was argued that geoengineering cannot replace mitigation and adaptation measures when it comes to dealing with climate change—hence, reduction of carbon dioxide emissions remains of utmost importance.

A simple expression is developed for covariance-matrix correction in stochastic model updating. The need for expensive forward propagation of uncertainty through the model is obviated by application of a formula based only on the sensitivity of the outputs at the end of a deterministic updating process carried out on the means of the parameters. Two previously published techniques are show to reduce to the same simple formula within the assumption of small perturbation about the mean. It is shown, using a simple numerical example, that deterministic updating of the parameter means can result in correct reconstruction of the output means even when the updating parameters are wrongly chosen. If the parameters are correctly chosen, then the covariance matrix of the outputs is correctly reconstructed, but when the parameters are wrongly chosen is found that the output covariance is generally not reconstructed accurately. Therefore, the selection of updating parameters on the basis of reconstructing the output means is not sufficient to ensure that the output covariances will be well reconstructed. Further theory is then developed by assessing the contribution of each candidate parameter to the output covariance matrix, thereby enabling the selection of updating parameters to ensure that both the output means and covariances are reconstructed by the updated model. This latter theory is supported by further numerical examples.

OBJECTIVE The study objective was to evaluate how the use of a pervasive blood glucose monitoring (BGM) technology relates to glycemic control, report of self-care behavior, and emotional response to BGM of children with type 1 diabetes and their parents. RESEARCH DESIGN AND METHODS Forty-eight children aged less than 12 years (mean 8.8 years) with type 1 diabetes were randomly assigned to one of two study groups, a control group (conventional care without technology) or an experimental group (conventional care with technology), and followed for 12 months. Families in the experimental group were given the Automated Diabetes Management System (ADMS), which automatically collects blood glucose (BG) values and sends to parent(s) a 21-day BG trending report via e-mail each night. Measures of glycemic control (HbA1c) were collected at baseline and at quarterly diabetes clinic visits; BGM effect and diabetes self-care behavior measures were obtained at the baseline, 6-month, and 12-month visits. RESULTS Children in the experimental group had significantly (P = 0.01) lower HbA1c at 12 months (7.44 ± 0.94, −0.35 from baseline) than controls (8.31 ± 1.24, +0.15 from baseline). Improvement in HbA1c was more profound in families using the ADMS more frequently. In addition, in these families, parents showed a significant improvement in BGM effect (P = 0.03) and children became more meticulous in diabetes self-care (P = 0.04). Children in both experimental and control groups experienced no change in their emotional response to BGM. CONCLUSIONS Using the ADMS 1–3 times/week may help children with type 1 diabetes improve glycemic control and gain diabetes self-management skills, as well as improve the BGM effect of parents.

The sensitivity method is probably the most successful of the many approaches to the problem of updating finite element models of engineering structures based on vibration test data. It has been applied successfully to large-scale industrial problems and proprietary codes are available based on the techniques explained in simple terms in this article. A basic introduction to the most important procedures of computational model updating is provided, including tutorial examples to reinforce the reader’s understanding and a large scale model updating example of a helicopter airframe.

A bioeconomic model of key fisheries of the Barents Sea is run with scenarios generated by an earth system model of intermediate complexity to assess how the Barents Sea fisheries of cod (Gadus morhua) and capelin (Mallotus villosus) are affected by changes in the Atlantic thermohaline circulation (THC) arising from anthropogenic climate change. Changes in hydrographic conditions have an impact on recruitment success and survival rates, which constitute a lasting effect on the stocks. The economic development of the fisheries is determined for the 21st century, considering a purely stock size based and a coupled stock size-hydrography based harvesting strategy. Results show that a substantial weakening of the THC leads to impaired cod stock development, causing the associated fishery to become unprofitable in the long run. Simultaneous improvements in capelin stock development help the capelin fishery, but are insufficient to offset the losses incurred by the cod fishery. A comparison of harvest strategies reveals that in times of high variability in stock development, coupled stock size-hydrography based management leads to more stable economic results of these fisheries than the stock size based fishing strategy.

The problem of stochastic model updating is addressed by means of the application of two methods (covariance and interval model updating) to the DLR AIRMOD structure which is repeatedly disassembled and reassembled to provide a database of modal variability due to uncertainty in joint and support stiffnesses and masses of cables and screws. The covariance method is based on an assumption of small uncertainty and implemented at each step of an iterative approach by forward propagation of uncertain parameters using a multivariate normal distribution. The interval approach is based on a Kriging meta-model, thereby providing a very efficient surrogate to replace the expensive full finite element model. This allows a mapping from multiple output measurements to define a hypercube bounded by intervals of parameter uncertainty. It is shown that the measured data is fully enclosed by the hyper-ellipses and hypercubes of the covariance and interval methods respectively. As expected, the interval method is found to be more conservative than the covariance approach but still provides useful estimates without restriction by any assumption of probability distribution.

Ground vibration tests (GVTs) on aircraft prototypes are mainly performed to experimentally identify the structural dynamic behaviour in terms of a modal model. This assumes a linear dynamic behaviour of the structure. However, in the practice of ground vibration testing it is often observed that structures do not behave in a perfectly linear manner. Non-linearities can be determined, for example, by free play in junctions, hydraulic systems in control surfaces, or friction. This paper compiles measured, typical, non-linear phenomena from various GVTs on large aircraft. The standard procedure in GVTs nowadays is the application of the Harmonic Balance method which linearizes the dynamic behaviour on the level of excitation. The procedure requires a harmonic excitation of the structure which is usually performed during phase resonance testing. The non-linear behaviour is investigated in terms of linearity plots in which the resonance frequency of a mode is plotted as a function of the excitation level. The experimental data is then compatible with all post-processing procedures for the measured results, e.g. updating of the finite element model or flutter calculations. This paper shows measured linearity plots for some typical non-linear phenomena. In the second part of the paper analytical linearity plots for different non-linear stiffness and damping models are considered in order to investigate whether the type of non-linearity can be identified from measured linearity plots. The analytical linearity plots are discussed with respect to their application limits. The analytical linearity plots are used to interpret the experimental linearity plots stemming from various GVTs on different aircraft prototypes. Finally, the observability of non-linear stiffness and non-linear damping characteristics via linearity plots is assessed.

2 ABSTRACT. A new sphinctozoid sponge - Fanthalamia kadiri - is described from the Upper Triassic (Carnian) of the Antalya area, southern Turkey. This is the second species of the genus Fanthalamia found in Upper Triassic rocks of Turkey. Key Words: Sponge, "Sphinctozoa", Triassic, Carnian, Turkey

In this paper two different computational model updating (CMU) methods are compared. Both procedures make use of the inverse sensitivity approach. The residuals of the first method are formed by eigenvalue and mode shape differences whereas the residuals of the second method include eigenvalue and frequency response errors. Computational model updating of physical mass, stiffness and geometric parameters is possible with the first technique. The second method additionally allows updating of viscous modal damping parameters. This second method uses directly measured frequency response data taken only at the resonance peaks. Since both methods allow to handle incomplete test data vectors, that means that the number of measured degrees of freedom (dof) is much less than the dof no. of the mathematical model, they are able to deal with large order aerospace finite element (FE) models. Both procedures were used to investigate the prediction capability of an updated analytical model of a benchmark test structure with respect to the test data of a modified structure. The results of both techniques are compared, advantages and disadvantages are pointed out and an assessment with respect to the operational validity is given.

Probabilistic and interval model updating methods are described, with particular attention paid to variability in nominally identical test structures due, for example, to the effect of accumulated manufacturing tolerances, or degradation of performance caused by wear of engineering components. In such cases the updating parameter distributions are meaningful physically either as PDFs or as intervals. Stochastic model updating is an inverse problem, generally requiring multiple forward solutions, which may be carried out very efficiently by the use of surrogates, in place of full FE models. The procedure is illustrated by experimental examples, including model updating of (i) a frame structure with uncertain locations of two internal beams and (ii) the DLR AIRMOD structure, which displays vibration characteristics very similar to those of a real aircraft.

A colonial serpulid worm tube, Filograna minor nov. sp., from the Anisian reef boulders of the Karaburun Peninsula, Western Turkey is described. The Filograna-bearing boulders occur together with Anisian reef boulders within the Upper Anisian siliciclastic deposits of the Gerence Formation. Filograna minor differs from the Norian species Filograna serialis, described by Senowbari-Daryan and Link from the Taurus Mountains, by the smaller dimensions of the tubes.

Recent research has provided new insights into the relationship between climate change and violent conflict. In this review we compare the results, methodologies, and data applied in the peer-reviewed literature to recap the current state of the debate. While long-term historical studies suggest a coincidence between climate variability and armed conflict, empirical findings are less conclusive for recent periods. Disentangling the climate-conflict nexus, we discuss causal pathways such as precipitation changes, freshwater scarcity, food insecurity, weather extremes, and environmental migration. A geographic differentiation indicates that countries with low human development are particularly vulnerable to the double exposure of natural disasters and armed conflict. Thus, effective institutional frameworks and governance mechanisms are important to prevent climate-induced conflicts and to strengthen cooperation. Applying an integrative framework connecting climate change, natural resources, human security, and societal stability, we pinpoint future research needs.