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3. The IPTA Nashville consensus conference on Post-Transplant lymphoproliferative disorders after solid organ transplantation in children: II-consensus guidelines for prevention

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Green, Michael, Squires, James E., Chinnock, Richard E., Comoli, Patrizia, Danziger‐Isakov, Lara, Dulek, Daniel E., Esquivel, Carlos O., Höcker, Britta, L'Huillier, Arnaud G., Mazariegos, George Vincent, Visner, Gary A., Bollard, Catherine M., Dipchand, Anne I., Ferry, Judith A., Gross, Thomas G., Hayashi, Robert, Maecker‐Kolhoff, Britta, Marks, Stephen, Martinez, Olivia M., Metes, Diana M., Michaels, Marian G., Preiksaitis, Jutta, Smets, Françoise, Swerdlow, Stephen H., Trappe, Ralf U., Wilkinson, James D., Allen, Upton, Webber, Steven A., Dharnidharka, Vikas R., UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Green, Michael, Squires, James E., Chinnock, Richard E., Comoli, Patrizia, Danziger‐Isakov, Lara, Dulek, Daniel E., Esquivel, Carlos O., Höcker, Britta, L'Huillier, Arnaud G., Mazariegos, George Vincent, Visner, Gary A., Bollard, Catherine M., Dipchand, Anne I., Ferry, Judith A., Gross, Thomas G., Hayashi, Robert, Maecker‐Kolhoff, Britta, Marks, Stephen, Martinez, Olivia M., Metes, Diana M., Michaels, Marian G., Preiksaitis, Jutta, Smets, Françoise, Swerdlow, Stephen H., Trappe, Ralf U., Wilkinson, James D., Allen, Upton, Webber, Steven A., and Dharnidharka, Vikas R.

Abstract

The International Pediatric Transplant Association (IPTA) convened an expert consensus conference to assess current evidence and develop recommendations for various aspects of care relating to post-transplant lymphoproliferative disorder after solid organ transplantation in children. In this report from the Prevention Working Group, we reviewed the existing literature regarding immunoprophylaxis and chemoprophylaxis, and pre-emptive strategies. While the group made a strong recommendation for pre-emptive reduction of immunosuppression at the time of EBV DNAemia (low to moderate evidence), no recommendations for use could be made for any prophylactic strategy or alternate pre-emptive strategy, largely due to insufficient or conflicting evidence. Current gaps and future research priorities are highlighted.

Published
2022

8. Prospective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation.

Author

Zahorchak, Alan F., Ezzelarab, Mohamed B., Thomson, Angus W., Lakkis, Fadi G., Metes, Diana M., and Butterfield, Lisa H.

Subjects
DENDRITIC cells, TRANSPLANTATION immunology, IMMUNOREGULATION
Abstract

Dendritic cells (DC) are rare, professional antigen-presenting cells with ability to induce or regulate alloimmune responses. Regulatory DC (DCreg) with potential to down-modulate acute and chronic inflammatory conditions that occur in organ transplantation can be generated in vitro under a variety of conditions. Here, we provide a rationale for evaluation of DCreg therapy in clinical organ transplantation with the goal of promoting sustained, donor-specific hyporesponsiveness, while lowering the incidence and severity of rejection and reducing patients' dependence on anti-rejection drugs. Generation of donor- or recipient-derived DCreg that suppress T cell responses and prolong transplant survival in rodents or non-human primates has been well-described. Recently, good manufacturing practice (GMP)-grade DCreg have been produced at our Institution for prospective use in human organ transplantation. We briefly review experience of regulatory immune therapy in organ transplantation and describe our experience generating and characterizing human monocyte-derived DCreg. We propose a phase I/II safety study in which the influence of donor-derived DCreg combined with conventional immunosuppression on subclinical and clinical rejection and host alloimmune responses will be examined in detail. [ABSTRACT FROM AUTHOR]

Published
2016
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