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1. Ventilatory associated barotrauma in COVID-19 patients: A multicenter observational case control study (COVI-MIX-study)

Author

Vetrugno, Luigi, Castaldo, Nadia, Fantin, Alberto, Deana, Cristian, Cortegiani, Andrea, Longhini, Federico, Forfori, Francesco, Cammarota, Gianmaria, Grieco, Domenico Luca, Isola, Miriam, Navalesi, Paolo, Maggiore, Salvatore Maurizio, Bassetti, Matteo, Chetta, Alfredo, Confalonieri, Marco, De Martino, Maria, Ferrari, Giovanni, Francisi, Daniela, Luzzati, Roberto, Meini, Simone, Scozzafava, Mariano, Sozio, Emanuela, Tascini, Carlo, Bassi, Flavio, Patruno, Vincenzo, De Robertis, Edoardo, Aldieri, Chiara, Ball, Lorenzo, Baratella, Elisa, Bartoletti, Michele, Boscolo, Annalisa, Burgazzi, Barbara, Catalanotti, Vito, Confalonieri, Paola, Corcione, Silvia, De Rosa, Francesco Giuseppe, De Simoni, Alessandro, Bono, Valerio Del, Tria, Roberta Di, Forlani, Sara, Giacobbe, Daniele Roberto, Granozzi, Bianca, Labate, Laura, Lococo, Sara, Lupia, Tommaso, Matellon, Carola, Mehrabi, Sara, Morosi, Sabrina, Mongodi, Silvia, Mura, Maddalena, Nava, Stefano, Pol, Riccardo, Pettenuzzo, Tommaso, Quyen, Nguyen Hoang, Rescigno, Carolina, Righi, Elda, Ruaro, Barbara, Salton, Francesco, Scabini, Silvia, Scarda, Angelo, Sibani, Marcella, Tacconelli, Evelina, Tartaglione, Gennaro, Tazza, Beatrice, Vania, Eleonora, Viale, Pierluigi, Vianello, Andrea, Visentin, Alessandro, Zuccon, Umberto, Meroi, Francesco, and Buonsenso, Danilo

Published
2023
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6. Transcranial ultrasonography imaging of a suprasellar meningioma: A case description and technical notes.

Author

Meini, Simone, Rossi, Carlo, Venturini, Luigi, Mura, Maddalena, Bracalente, Irene, Andreini, Roberto, Sgura, Andrea, and Cozza, Sabino

Subjects
*SEPTIC shock treatment, *BRAIN, *TRANSCRANIAL Doppler ultrasonography, *MAGNETIC resonance imaging, *MENINGIOMA, *HOSPITAL care, *COMA, *COMPUTED tomography
Abstract

Background: Computed tomography (CT) and magnetic resonance (MR) represent the gold standard for evaluating intracranial tumours, such as meningiomas; most meningiomas can be managed by surveillance and clinical follow‐up, therefore, the ideal technology should be cheap, non‐invasive, safe and able to reduce radiation exposure. Transcranial colour‐coded duplex sonography (TCCS) can detect space‐occupying lesions, but its full potential for clinical practice is still unexpressed. Aims and Methods: We describe the ability of TCCS to directly and accurately image, in a 77‐year‐old woman hospitalised for septic shock and coma, a suprasellar meningioma with a spatial resolution very similar to CT. Results: The meningioma was clearly visualised as a roundish mass, with well‐defined borders, heterogeneously hyperechogenic compared with the surrounding brain structures; multiple intralesional calcifications were detectable as highly echogenic spots. Latero‐lateral and antero‐posterior diameters were well measurable. Discussion: TCCS should not be considered as an alternative to CT and MR imaging, but it might have a complementary role, useful for use at the bedside in uncooperative or non‐transportable patients and for follow‐up, when an adequate acoustic window is guaranteed. Neurologists and neuroradiologists should further explore the full potential of this technology. [ABSTRACT FROM AUTHOR]

Published
2023
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8. D-Dimer as Biomarker for Early Prediction of Clinical Outcomes in Patients With Severe Invasive Infections Due to Streptococcus Pneumoniae and Neisseria Meningitidis

Author

Meini, Simone, primary, Sozio, Emanuela, additional, Bertolino, Giacomo, additional, Sbrana, Francesco, additional, Ripoli, Andrea, additional, Pallotto, Carlo, additional, Viaggi, Bruno, additional, Andreini, Roberto, additional, Attanasio, Vittorio, additional, Rescigno, Carolina, additional, Atripaldi, Luigi, additional, Leonardi, Silvia, additional, Bernardo, Mariano, additional, and Tascini, Carlo, additional

Published
2021
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12. Pneumatosis intestinalis in COVID-19

Author

Meini, Simone, primary, Zini, Chiara, additional, Passaleva, Maria Teresa, additional, Frullini, Anna, additional, Fusco, Francesca, additional, Carpi, Roberto, additional, and Piani, Fiorella, additional

Published
2020
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15. Comparison and combination of a hemodynamics/biomarkers-based model with simplified PESI score for prognostic stratification of acute pulmonary embolism: findings from a real world study

Author

Masotti, Luca, primary, Panigada, Grazia, additional, Landini, Giancarlo, additional, Pieralli, Filippo, additional, Corradi, Francesco, additional, Lenti, Salvatore, additional, Migliacci, Rino, additional, Nozzoli, Carlo, additional, Grazzini, Maddalena, additional, Ciucciarelli, Lucia, additional, Morettini, Alessandro, additional, Bucherelli, Sara, additional, Petrioli, Alessandra, additional, Casati, Carlotta, additional, Felici, Mario, additional, Ralli, Luciano, additional, Arrigucci, Stefano, additional, Teghini, Laila, additional, Porciello, Giovanni, additional, Spolveri, Stefano, additional, Baldoni, Daniele, additional, Frullini, Anna, additional, Cimolato, Barbara, additional, Lorenzini, Gianni, additional, Pampana, Alessandro, additional, Rinaldi, Guidantonio, additional, Bertieri, Maria, additional, Laureano, Raffaele, additional, Tatini, Stefano, additional, Fortini, Alberto, additional, Angotti, Chiara, additional, Verdiani, Valerio, additional, Romagnoli, Anna, additional, Cascinelli, Irene, additional, Camaiti, Alberto, additional, Mumoli, Nicola, additional, Cei, Marco, additional, Giuntoli, Stefano, additional, Alessandri, Massimo, additional, Palma, Alessandro, additional, Manini, Maurizio, additional, Crescenzo, Veronica, additional, Piacentini, Michele, additional, Passaglia, Carlo, additional, Tintori, Giancarlo, additional, Palermo, Carlo, additional, Dainelli, Alba, additional, Andreini, Roberto, additional, Levantino, Giuseppa, additional, Fabiani, Plinio, additional, Raimondi, Lucia, additional, Natale, Massimo, additional, Risaliti, Filippo, additional, Nassi, Rossella, additional, Mastriforti, Roberta, additional, Cappelli, Roberto, additional, Voglino, Michele, additional, Lambelet, Paola, additional, Fascetti, Stefano, additional, Cioppi, Adriano, additional, Carli, Valentina, additional, Tafi, Alessandro, additional, Meini, Simone, additional, Santoro, Emilio, additional, and Rosi, Claudia, additional

Published
2015
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19. Ventilatory associated barotrauma in COVID-19 patients: A multicenter observational case control study (COVI-MIX-study)

Author

Luigi Vetrugno, Nadia Castaldo, Alberto Fantin, Cristian Deana, Andrea Cortegiani, Federico Longhini, Francesco Forfori, Gianmaria Cammarota, Domenico Luca Grieco, Miriam Isola, Paolo Navalesi, Salvatore Maurizio Maggiore, Matteo Bassetti, Alfredo Chetta, Marco Confalonieri, Maria De Martino, Giovanni Ferrari, Daniela Francisi, Roberto Luzzati, Simone Meini, Mariano Scozzafava, Emanuela Sozio, Carlo Tascini, Flavio Bassi, Vincenzo Patruno, Edoardo De Robertis, Chiara Aldieri, Lorenzo Ball, Elisa Baratella, Michele Bartoletti, Annalisa Boscolo, Barbara Burgazzi, Vito Catalanotti, Paola Confalonieri, Silvia Corcione, Francesco Giuseppe De Rosa, Alessandro De Simoni, Valerio Del Bono, Roberta Di Tria, Sara Forlani, Daniele Roberto Giacobbe, Bianca Granozzi, Laura Labate, Sara Lococo, Tommaso Lupia, Carola Matellon, Sara Mehrabi, Sabrina Morosi, Silvia Mongodi, Maddalena Mura, Stefano Nava, Riccardo Pol, Tommaso Pettenuzzo, Nguyen Hoang Quyen, Carolina Rescigno, Elda Righi, Barbara Ruaro, Francesco Salton, Silvia Scabini, Angelo Scarda, Marcella Sibani, Evelina Tacconelli, Gennaro Tartaglione, Beatrice Tazza, Eleonora Vania, Pierluigi Viale, Andrea Vianello, Alessandro Visentin, Umberto Zuccon, Francesco Meroi, Danilo Buonsenso, Vetrugno, Luigi, Castaldo, Nadia, Fantin, Alberto, Deana, Cristian, Cortegiani, Andrea, Longhini, Federico, Forfori, Francesco, Cammarota, Gianmaria, Grieco, Domenico Luca, Isola, Miriam, Navalesi, Paolo, Maggiore, Salvatore Maurizio, Bassetti, Matteo, Chetta, Alfredo, Confalonieri, Marco, De Martino, Maria, Ferrari, Giovanni, Francisi, Daniela, Luzzati, Roberto, Meini, Simone, Scozzafava, Mariano, Sozio, Emanuela, Tascini, Carlo, Bassi, Flavio, Patruno, Vincenzo, De Robertis, Edoardo, Aldieri, Chiara, Ball, Lorenzo, Baratella, Elisa, Bartoletti, Michele, Boscolo, Annalisa, Burgazzi, Barbara, Catalanotti, Vito, Confalonieri, Paola, Corcione, Silvia, De Rosa, Francesco Giuseppe, De Simoni, Alessandro, Bono, Valerio Del, Tria, Roberta Di, Forlani, Sara, Giacobbe, Daniele Roberto, Granozzi, Bianca, Labate, Laura, Lococo, Sara, Lupia, Tommaso, Matellon, Carola, Mehrabi, Sara, Morosi, Sabrina, Mongodi, Silvia, Mura, Maddalena, Nava, Stefano, Pol, Riccardo, Pettenuzzo, Tommaso, Quyen, Nguyen Hoang, Rescigno, Carolina, Righi, Elda, Ruaro, Barbara, Salton, Francesco, Scabini, Silvia, Scarda, Angelo, Sibani, Marcella, Tacconelli, Evelina, Tartaglione, Gennaro, Tazza, Beatrice, Vania, Eleonora, Viale, Pierluigi, Vianello, Andrea, Visentin, Alessandro, Zuccon, Umberto, Meroi, Francesco, and Buonsenso, Danilo

Subjects
Pulmonary and Respiratory Medicine, High flow nasal cannula, Acute respiratory failure, Barotrauma, COVID-19, Invasive mechanical ventilation, Pneumothorax
Abstract

Background The risk of barotrauma associated with different types of ventilatory support is unclear in COVID- 19 patients. The primary aim of this study was to evaluate the effect of the different respiratory support strategies on barotrauma occurrence; we also sought to determine the frequency of barotrauma and the clinical characteristics of the patients who experienced this complication. Methods This multicentre retrospective case-control study from 1 March 2020 to 28 February 2021 included COVID-19 patients who experienced barotrauma during hospital stay. They were matched with controls in a 1:1 ratio for the same admission period in the same ward of treatment. Univariable and multivariable logistic regression (OR) were performed to explore which factors were associated with barotrauma and in-hospital death. Results We included 200 cases and 200 controls. Invasive mechanical ventilation was used in 39.3% of patients in the barotrauma group, and in 20.1% of controls (p

Published
2022

20. Early 3-day course of remdesivir to prevent progression to severe Covid-19 in high-risk patients with hospital-acquired SARS-CoV-2 infection: preliminary results from two Italian outbreaks.

Author

Meini S, Bracalente I, Bontempo G, Longo B, De Martino M, and Tascini C

Subjects
Humans, SARS-CoV-2, Retrospective Studies, Antiviral Agents therapeutic use, COVID-19 Drug Treatment, Italy epidemiology, COVID-19
Abstract

In multimorbid, unvaccinated and non-hospitalized patients, early administration of remdesivir, nirmatrelvir/ritonavir and molnupiravir was effective in reducing the risk of hospitalization or death from any cause. Similar data are lacking with regard to patients already hospitalized and who acquire in-hospital SARS-CoV-2 infection. We conducted a retrospective study during two outbreaks of SARS-CoV-2 infections involving 90 inpatients already hospitalized for medical or surgical conditions, in order to assess the effectiveness of early administration of remdesivir. Forty-seven cases were treated with a 3-day course of remdesivir (200 mg on day 1 and 100 mg on days 2 and 3) within a median time of 1.4 day from testing positive, and were compared to a matched case-control cohort of 43 untreated patients; matching was based on age, sex, vaccination status, previous symptomatic infections by SARS-CoV-2, reasons for hospitalization (no significant differences). No case presented adverse events to remdesivir or death from COVID-19. No significant difference in overall in-hospital mortality was observed in cases compared to controls (17% vs 16.3%, p=0.925), but progression to severe pneumonia, although the difference was still not significant, showed an evident trend of a better outcome (8.5% vs 16.3%, p=0.261). Moreover, cases had a median discharge delay of 3 days (p=0.008).

Published
2022

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