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Casearia tomentosa is a member of the Salicaceae family, which is also known as Chilla. Different portions of Casearia tomentosa have traditionally been used to treat ulcers, dropsy, fissures, malarial fever, tonsillitis pain, wounds, and plaster. This plant's extract indicated the presence of alkaloids, flavonoids, carbohydrates, glycosides, protein, steroids, phytosterol, terpenoids, lipids, and oils. The leaves have been shown to be a natural source of antioxidants, antidiabetic, and antibacterial properties. The available information was gathered from scientific databases using a keyword search in "Google Scholar," "Pub med," "Science direct," "Springer Link," "Wiley" and "Sci finder". Moreover, books were recommended for plant data and synthetic structure. Nonetheless, pharmacological information is very restricted. Subsequently, the point of this review is to give an extensive information of the botany, phytochemistry and pharmacology of Casearia tomentosa and to feature the holes in our insight for future exploration openings.