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15 results on '"Maximova, Ksenia"'

1. Femtosecond laser processing for blast-hole analysis: laser removal of slurry and effect on rocks

Author

Brand, Julia, Maximova, Ksenia, Madden, Steve, Rode, Andrei V., Mihankhah, Ehsan, Zigman, John, Hill, Andrew J., and Rapp, Ludovic

Subjects
Physics - Applied Physics
Abstract

This study investigates the possibility of using a femtosecond pulse laser to remove iron ore slurry used to stabilise blast-hole structures by mining industries, intending to preserve the wall's stability and the chemical and compositional properties of the underlying rock. In situ minerals are often coated in other material deposits, such as dust or slurry in blast holes. To analyse the rock materials beneath, its surface must be exposed by removal of the surface layer. The ablation depth per pulse and ablation efficiency of the slurry were determined using femtosecond laser pulses. Then, the ablation of rocks of economic interest in Australia, including banded iron, limonite, goethite, shale, and hematite, was studied to establish their ablation thresholds and rates. Any damage induced by the laser was investigated by optical microscopy, optical profilometry, colourimetry, VIS/NIR spectroscopy and Fourier Transform Infrared spectroscopy (FTIR)., Comment: 21 pages, 11 figures

Published
2024

8. Gold nanoparticles prepared by laser ablation in aqueous biocompatible solutions: assessment of safety and biological identity for nanomedicine applications

Author

Correard, Florian, Maximova, Ksenia, Esteve, Marie-Anne, Villard, Claude, Roy, Myriam, Al-Kattan, Ahmed, Sentis, Marc, Gingras, Marc, Kabashin, Andrei, Braguer, Diane, Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Timone [CHU - APHM] (TIMONE), Laboratoire Lasers, Plasmas et Procédés photoniques (LP3), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
inorganic chemicals, Cell Survival, [SDV]Life Sciences [q-bio], education, Metal Nanoparticles, Biocompatible Materials, Polyethylene Glycols, neuroblastoma, protein corona, International Journal of Nanomedicine, Cell Line, Tumor, Humans, health care economics and organizations, Original Research, Drug Carriers, green chemistry, Lasers, technology, industry, and agriculture, glioblastoma, Proteins, Water, Dextrans, Green Chemistry Technology, respiratory system, Nanomedicine, nanocarrier, cytotoxicity, Gold
Abstract

Due to excellent biocompatibility, chemical stability, and promising optical properties, gold nanoparticles (Au-NPs) are the focus of research and applications in nanomedicine. Au-NPs prepared by laser ablation in aqueous biocompatible solutions present an essentially novel object that is unique in avoiding any residual toxic contaminant. This paper is conceived as the next step in development of laser-ablated Au-NPs for future in vivo applications. The aim of the study was to assess the safety, uptake, and biological behavior of laser-synthesized Au-NPs prepared in water or polymer solutions in human cell lines. Our results showed that laser ablation allows the obtaining of stable and monodisperse Au-NPs in water, polyethylene glycol, and dextran solutions. The three types of Au-NPs were internalized in human cell lines, as shown by transmission electron microscopy. Biocompatibility and safety of Au-NPs were demonstrated by analyzing cell survival and cell morphology. Furthermore, incubation of the three Au-NPs in serum-containing culture medium modified their physicochemical characteristics, such as the size and the charge. The composition of the protein corona adsorbed on Au-NPs was investigated by mass spectrometry. Regarding composition of complement C3 proteins and apolipoproteins, Au-NPs prepared in dextran solution appeared as a promising drug carrier. Altogether, our results revealed the safety of laser-ablated Au-NPs in human cell lines and support their use for theranostic applications., Video abstract

Published
2014
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9. Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

Author

Tamarov, Konstantin P., Osminkina, Liubov A., Zinovyev, Sergey V., Maximova, Ksenia A., Kargina, Julia V., Gongalsky, Maxim B., Ryabchikov, Yury, Al-Kattan, Ahmed, Sviridov, Andrey P., Sentis, Marc, Ivanov, Andrey V., Nikiforov, Vladimir N., Kabashin, Andrei V., Timoshenko, Victor Yu, Lomonosov Moscow State University (MSU), Blokhin Cancer Research Center, N.N. Blokhin Russian Cancer Research Center, Laboratoire Lasers, Plasmas et Procédés photoniques (LP3), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), ANR-10-BLAN-0919,LASERNANOBIO,Synthèse 'verte' par ablation laser de nanomatériaux colloîdaux fonctionnalisés vers la détection et la thérapie du cancer(2010), and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Subjects
Radiotherapy, Nanotechnology in cancer, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic
Abstract

International audience; Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF) radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively target cancer cells and thus avoid side effects. Here, we assess crystalline silicon (Si) based nanomaterials as sensitizers for the RF-induced therapy. Using nanoparticles produced by mechanical grinding of porous silicon and ultraclean laser- ablative synthesis, we report efficient RF-induced heating of aqueous suspensions of the nanoparticles to temperatures above 45-50 degrees C under relatively low nanoparticle concentrations (< 1 mg/mL) and RF radiation intensities (1-5 W/cm(2)). For both types of nanoparticles the heating rate was linearly dependent on nanoparticle concentration, while laser-ablated nanoparticles demonstrated a remarkably higher heating rate than porous silicon-based ones for the whole range of the used concentrations from 0.01 to 0.4 mg/mL. The observed effect is explained by the Joule heating due to the generation of electrical currents at the nanoparticle/water interface. Profiting from the nanoparticle-based hyperthermia, we demonstrate an efficient treatment of Lewis lung carcinomain in vivo. Combined with the possibility of involvement of parallel imaging and treatment channels based on unique optical properties of Si-based nanomaterials, the proposed method promises a new landmark in the development of new modalities for mild cancer therapy.

Published
2014
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11. Gold nanoparticles prepared by laser ablation in aqueous biocompatible solutions: assessment of safety and biological identity for nanomedicine applications

Author

Correard,Florian, Maximova,Ksenia, Estève,Marie-Anne, Villard,Claude, Roy,Myriam, Al-Kattan,Ahmed, Sentis,Marc, Gingras,Marc, Kabashin,Andrei V, Braguer,Diane, Correard,Florian, Maximova,Ksenia, Estève,Marie-Anne, Villard,Claude, Roy,Myriam, Al-Kattan,Ahmed, Sentis,Marc, Gingras,Marc, Kabashin,Andrei V, and Braguer,Diane

Abstract

Florian Correard,1,2 Ksenia Maximova,3 Marie-Anne Estève,1,2 Claude Villard,1 Myriam Roy,4 Ahmed Al-Kattan,3 Marc Sentis,3 Marc Gingras,4 Andrei V Kabashin,3 Diane Braguer1,2 1Aix Marseille Université, INSERM, CR02 UMR_S911, Marseille, France; 2APHM, Hôpital Timone, Marseille, France; 3Aix Marseille Université, CNRS, LP3 UMR 7341, Marseille, France; 4Aix Marseille Université, CNRS, CINAM, UMR 7325 Marseille, France Abstract: Due to excellent biocompatibility, chemical stability, and promising optical properties, gold nanoparticles (Au-NPs) are the focus of research and applications in nanomedicine. Au-NPs prepared by laser ablation in aqueous biocompatible solutions present an essentially novel object that is unique in avoiding any residual toxic contaminant. This paper is conceived as the next step in development of laser-ablated Au-NPs for future in vivo applications. The aim of the study was to assess the safety, uptake, and biological behavior of laser-synthesized Au-NPs prepared in water or polymer solutions in human cell lines. Our results showed that laser ablation allows the obtaining of stable and monodisperse Au-NPs in water, polyethylene glycol, and dextran solutions. The three types of Au-NPs were internalized in human cell lines, as shown by transmission electron microscopy. Biocompatibility and safety of Au-NPs were demonstrated by analyzing cell survival and cell morphology. Furthermore, incubation of the three Au-NPs in serum-containing culture medium modified their physicochemical characteristics, such as the size and the charge. The composition of the protein corona adsorbed on Au-NPs was investigated by mass spectrometry. Regarding composition of complement C3 proteins and apolipoproteins, Au-NPs prepared in dextran solution appeared as a promising drug carrier. Altogether, our results revealed the safety of laser-ablated Au-NPs in human cell lines and support their use for theranostic applicat

Published
2014

13. Ultra-pure, water-dispersed Au nanoparticles produced by femtosecond laser ablation and fragmentation

Author

Kubiliūtė,Reda, Maximova,Ksenia A, Lajevardipour,Alireza, Yong,Jiawey, Hartley,Jennifer S, Mohsin,Abu SM, Blandiin,Pierre, Chon,James WM, Sentis,Marc, Stoddart,Paul R, Kabashin,Andrei, Rotomskis,Ričardas, Clayton,Andrew HA, Juodkazis,Saulius, Kubiliūtė,Reda, Maximova,Ksenia A, Lajevardipour,Alireza, Yong,Jiawey, Hartley,Jennifer S, Mohsin,Abu SM, Blandiin,Pierre, Chon,James WM, Sentis,Marc, Stoddart,Paul R, Kabashin,Andrei, Rotomskis,Ričardas, Clayton,Andrew HA, and Juodkazis,Saulius

Abstract

Reda Kubiliūtė,1,2 Ksenia A Maximova,3 Alireza Lajevardipour,1 Jiawey Yong,1 Jennifer S Hartley,1 Abu SM Mohsin,1 Pierre Blandin,3 James WM Chon,1 Marc Sentis,3 Paul R Stoddart,1 Andrei Kabashin,3 Ričardas Rotomskis,2 Andrew HA Clayton,1,4 Saulius Juodkazis1,4 1Centre for Micro-Photonics and Industrial Research Institute Swinburne, Faculty of Engineering and Industrial Sciences Swinburne University of Technology, Hawthorn, VIC, Australia; 2Laboratory of Biomedical Physics, Vilnius University Institute of Oncology, Baublio, Vilnius, Lithuania; 3Aix-Marseille University, Centre National de la Recherche Scientifique (CNRS), Lasers, Plasmas and Photonics Processing Laboratory, Campus de Luminy, Marseille, France; 4The Australian National Fabrication Facility, Victoria node, Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia Abstract: Aqueous solutions of ultra-pure gold nanoparticles have been prepared by methods of femtosecond laser ablation from a solid target and fragmentation from already formed colloids. Despite the absence of protecting ligands, the solutions could be (1) fairly stable and poly size-dispersed; or (2) very stable and monodispersed, for the two fabrication modalities, respectively. Fluorescence quenching behavior and its intricacies were revealed by fluorescence lifetime imaging microscopy in rhodamine 6G water solution. We show that surface-enhanced Raman scattering of rhodamine 6G on gold nanoparticles can be detected with high fidelity down to micromolar concentrations using the nanoparticles. Application potential of pure gold nanoparticles with polydispersed and nearly monodispersed size distributions are discussed. Keywords: nanotechnologies applications, methods of nanofabrication and processing, materials for nanomedicine

Published
2013

15. Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy.

Author

Tamarov KP, Osminkina LA, Zinovyev SV, Maximova KA, Kargina JV, Gongalsky MB, Ryabchikov Y, Al-Kattan A, Sviridov AP, Sentis M, Ivanov AV, Nikiforov VN, Kabashin AV, and Timoshenko VY

Subjects
Animals, Carcinoma, Lewis Lung pathology, Catheter Ablation instrumentation, Crystallization, Hindlimb, Hyperthermia, Induced instrumentation, Injections, Intralesional, Lasers, Male, Mice, Mice, Inbred CBA, Nanoparticles chemistry, Neoplasm Transplantation, Porosity, Temperature, Carcinoma, Lewis Lung therapy, Catheter Ablation methods, Hyperthermia, Induced methods, Nanoparticles administration & dosage, Silicon chemistry
Abstract

Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF) radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively target cancer cells and thus avoid side effects. Here, we assess crystalline silicon (Si) based nanomaterials as sensitizers for the RF-induced therapy. Using nanoparticles produced by mechanical grinding of porous silicon and ultraclean laser-ablative synthesis, we report efficient RF-induced heating of aqueous suspensions of the nanoparticles to temperatures above 45-50 °C under relatively low nanoparticle concentrations (<1 mg/mL) and RF radiation intensities (1-5 W/cm(2)). For both types of nanoparticles the heating rate was linearly dependent on nanoparticle concentration, while laser-ablated nanoparticles demonstrated a remarkably higher heating rate than porous silicon-based ones for the whole range of the used concentrations from 0.01 to 0.4 mg/mL. The observed effect is explained by the Joule heating due to the generation of electrical currents at the nanoparticle/water interface. Profiting from the nanoparticle-based hyperthermia, we demonstrate an efficient treatment of Lewis lung carcinoma in vivo. Combined with the possibility of involvement of parallel imaging and treatment channels based on unique optical properties of Si-based nanomaterials, the proposed method promises a new landmark in the development of new modalities for mild cancer therapy.

Published
2014
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