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2. Infections increase the risk of decompensation and death in patients with early alcohol-related liver disease

Author

Anastasiadou, Ema, Arumugam, Manimozhian, Bork, Peer, Hansen, Torben, Presto, Jenny, Israelsen, Hans, Karsdal, Morten, Legido-Quigley, Cristina, Melberg, Hans Olav, Thiele, Maja, Trebicka, Jonel, Krag, Aleksander, Mann, Mathias, Matthijnssens, Jelle, Johansen, Stine, Langkjær, Simon, Rasmussen, Ditlev Nytoft, Israelsen, Mads, Torp, Nikolaj, Lindvig, Katrine, Kjærgaard, Maria, Hansen, Johanne Kragh, Hansen, Camilla Dalby, Thorhauge, Katrine, Andersen, Peter, Detlefsen, Sönke, Juel, Helene Bæk, and Justesen, Ulrik Stenz

Published
2024
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3. Sphingolipids Are Depleted in Alcohol-Related Liver Fibrosis

Author

Bork, Peer, Mann, Mathias, Matthijnssens, Jelle, Krag, Aleksander, Hansen, Torben, Anastasiadou, Ema, Arumugam, Manimozhiyan, Henrar, Roland, Israelsen, Hans, Karsdal, Morten, Legido-Quigley, Cristina, Melberg, Hans Olav, Thiele, Maja, Trebicka, Jonel, Suvitaival, Tommi, Trošt, Kajetan, Kim, Min, de Zawadzki, Andressa, Kjaergaard, Maria, Rasmussen, Ditlev Nytoft, Lindvig, Katrine Prier, Israelsen, Mads, Detlefsen, Sönke, Andersen, Peter, Juel, Helene Bæk, Nielsen, Trine, Georgiou, Stella, Filippa, Vicky, Kuhn, Michael, Nishijima, Suguru, Moitinho-Silva, Lucas, and Rossing, Peter

Published
2023
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4. Best Practices for Successfully Writing and Publishing a Genome Announcement in Microbiology Resource Announcements

Author

Hotopp, Julie C Dunning, Baltrus, David A, Bruno, Vincent M, Dennehy, John J, Gill, Steven R, Maresca, Julia A, Matthijnssens, Jelle, Newton, Irene LG, Putonti, Catherine, Rasko, David A, Rokas, Antonis, Roux, Simon, Stajich, Jason E, Stedman, Kenneth M, Stewart, Frank J, and Thrash, J Cameron

Subjects
Microbiology, Biological Sciences
Abstract

Microbiology Resource Announcements (MRA) provides peer-reviewed announcements of scientific resources for the microbial research community. We describe the best practices for writing an announcement that ensures that these publications are truly useful resources. Adhering to these best practices can lead to successful publication without the need for extensive revisions.

Published
2020

5. Best Practices for Successfully Writing and Publishing a Genome Announcement in Microbiology Resource Announcements.

Author

Dunning Hotopp, Julie C, Baltrus, David A, Bruno, Vincent M, Dennehy, John J, Gill, Steven R, Maresca, Julia A, Matthijnssens, Jelle, Newton, Irene LG, Putonti, Catherine, Rasko, David A, Rokas, Antonis, Roux, Simon, Stajich, Jason E, Stedman, Kenneth M, Stewart, Frank J, and Thrash, J Cameron

Abstract

Microbiology Resource Announcements (MRA) provides peer-reviewed announcements of scientific resources for the microbial research community. We describe the best practices for writing an announcement that ensures that these publications are truly useful resources. Adhering to these best practices can lead to successful publication without the need for extensive revisions.

Published
2020

10. Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt

Author

de Miranda, Joachim R., Brettell, Laura E., Chejanovsky, Nor, Childers, Anna K., Dalmon, Anne, Deboutte, Ward, de Graaf, Dirk C., Doublet, Vincent, Gebremedhn, Haftom, Genersch, Elke, Gisder, Sebastian, Granberg, Fredrik, Haddad, Nizar J., Kaden, Rene, Manley, Robyn, Matthijnssens, Jelle, Meeus, Ivan, Migdadi, Hussein, Milbrath, Meghan O., Mondet, Fanny, Remnant, Emily J., Roberts, John M. K., Ryabov, Eugene V., Sela, Noa, Smagghe, Guy, Somanathan, Hema, Wilfert, Lena, Wright, Owen N., Martin, Stephen J., and Ball, Brenda V.

Published
2022
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11. Metagenomic Detection and Genetic Characterization of Human Sapoviruses among Children with Acute Flaccid Paralysis in Nigeria

Author

George, Uwem Etop, primary, Faleye, Temitope O. C., additional, De Coninck, Lander, additional, Agbaje, Sheriff Tunde, additional, Ifeorah, Ijeoma Maryjoy, additional, Onoja, Bernard Anyebe, additional, Oni, Elijah Igbekele, additional, Olayinka, Adebowale Oluseyi, additional, Ajileye, Toluwani Goodnews, additional, Oragwa, Arthur Obinna, additional, Akinleye, Toluwanimi Emmanuel, additional, Popoola, Bolutife Olubukola, additional, Osasona, Oluwadamilola Gideon, additional, Olayinka, Olaitan Titilola, additional, George, Oluwadamilola Adefunke, additional, Muhammad, Ahmed Iluoreh, additional, Komolafe, Isaac, additional, Adeniji, Adekunle Johnson, additional, Matthijnssens, Jelle, additional, and Adewumi, Moses Olubusuyi, additional

Published
2024
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12. Meeting Report of the Second Symposium of the Belgian Society for Viruses of Microbes and Launch of the Phage Valley

Author

Desmecht, Salomé, primary, Latka, Agnieszka, additional, Ceyssens, Pieter-Jan, additional, Garcia-Pino, Abel, additional, Gillis, Annika, additional, Lavigne, Rob, additional, Lima-Mendez, Gipsi, additional, Matthijnssens, Jelle, additional, Vázquez, Roberto, additional, Venneman, Jolien, additional, Wagemans, Jeroen, additional, Briers, Yves, additional, and Thiry, Damien, additional

Published
2024
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14. Meeting Report of the Second Symposium of the Belgian Society for Viruses of Microbes and Launch of the Phage Valley

Author

Desmecht, Salomé, Latka, Agnieszka, Ceyssens, Pieter-Jan, Garcia-Pino, Abel, Gillis, Annika, Lavigne, Rob, Lima Mendez, Gipsi, Matthijnssens, Jelle, Vázquez, Roberto, Venneman, Jolien, Wagemans, Jeroen, Briers, Yves, Thiry, Damien, Desmecht, Salomé, Latka, Agnieszka, Ceyssens, Pieter-Jan, Garcia-Pino, Abel, Gillis, Annika, Lavigne, Rob, Lima Mendez, Gipsi, Matthijnssens, Jelle, Vázquez, Roberto, Venneman, Jolien, Wagemans, Jeroen, Briers, Yves, and Thiry, Damien

Abstract

The second symposium of the Belgian Society for Viruses of Microbes (BSVoM) took place on 8 September 2023 at the University of Liège with 141 participants from 10 countries. The meeting program covered three thematic sessions opened by international keynote speakers: two sessions were devoted to “Fundamental research in phage ecology and biology” and the third one to the “Present and future applications of phages”. During this one day symposium, four invited keynote lectures, nine selected talks and eight student pitches were given along with thirty presented posters. The president of the Belgian Society for Viruses of Microbes, Prof. Yves Briers, took advantage of this symposium to launch the Phage Valley concept that will put the spotlight on the exceptionally high density of researchers investigating viruses of microbes as well as the successful triple helix approach between academia, industry and government in Belgium., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2024

15. A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

Author

Sanchez-Felipe, Lorena, Vercruysse, Thomas, Sharma, Sapna, Ma, Ji, Lemmens, Viktor, Van Looveren, Dominique, Arkalagud Javarappa, Mahadesh Prasad, Boudewijns, Robbert, Malengier-Devlies, Bert, Liesenborghs, Laurens, Kaptein, Suzanne J. F., De Keyzer, Carolien, Bervoets, Lindsey, Debaveye, Sarah, Rasulova, Madina, Seldeslachts, Laura, Li, Li-Hsin, Jansen, Sander, Yakass, Michael Bright, Verstrepen, Babs E., Böszörményi, Kinga P., Kiemenyi-Kayere, Gwendoline, van Driel, Nikki, Quaye, Osbourne, Zhang, Xin, ter Horst, Sebastiaan, Mishra, Niraj, Deboutte, Ward, Matthijnssens, Jelle, Coelmont, Lotte, Vandermeulen, Corinne, Heylen, Elisabeth, Vergote, Valentijn, Schols, Dominique, Wang, Zhongde, Bogers, Willy, Kuiken, Thijs, Verschoor, Ernst, Cawthorne, Christopher, Van Laere, Koen, Opdenakker, Ghislain, Vande Velde, Greetje, Weynand, Birgit, Teuwen, Dirk E., Matthys, Patrick, Neyts, Johan, Jan Thibaut, Hendrik, and Dallmeier, Kai

Published
2021
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16. Aedes Mosquito Virome in Southwestern Cameroon: Lack of Core Virome, But a Very Rich and Diverse Virome in Ae. africanus Compared to Other Aedes Species.

Author

Mbigha Donfack, Karelle Celes, De Coninck, Lander, Ghogomu, Stephen Mbigha, and Matthijnssens, Jelle

Subjects
AEDES albopictus, WHOLE genome sequencing, AEDES, SPECIES pools, MOSQUITOES, AEDES aegypti
Abstract

In Cameroon, Aedes mosquitoes transmit various arboviruses, posing significant health risks. We aimed to characterize the Aedes virome in southwestern Cameroon and identify potential core viruses which might be associated with vector competence. A total of 398 Aedes mosquitoes were collected from four locations (Bafoussam, Buea, Edea, and Yaounde). Aedes albopictus dominated all sites except for Bafoussam, where Aedes africanus prevailed. Metagenomic analyses of the mosquitoes grouped per species into 54 pools revealed notable differences in the eukaryotic viromes between Ae. africanus and Ae. albopictus, with the former exhibiting greater richness and diversity. Thirty-seven eukaryotic virus species from 16 families were identified, including six novel viruses with near complete genome sequences. Seven viruses were further quantified in individual mosquitoes via qRT-PCR. Although none of them could be identified as core viruses, Guangzhou sobemo-like virus and Bafoussam mosquito solemovirus, were highly prevalent regionally in Ae. albopictus and Ae. africanus, respectively. This study highlights the diverse eukaryotic virome of Aedes species in southwestern Cameroon. Despite their shared genus, Aedes species exhibit limited viral sharing, with varying viral abundance and prevalence across locations. Ae. africanus, an understudied vector, harbors a rich and diverse virome, suggesting potential implications for arbovirus vector competence. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Infections Increase The Risk Of Decompensation And Death In Patients With Early Alcohol-Related Liver Disease

Author

Johansen, Stine, primary, Langkjær, Simon, additional, Rasmussen, Ditlev Nytoft, additional, Israelsen, Mads, additional, Torp, Nikolaj, additional, Lindvig, Katrine, additional, Kjærgaard, Maria, additional, Hansen, Johanne Kragh, additional, Hansen, Camilla Dalby, additional, Thorhauge, Katrine, additional, Andersen, Peter, additional, Detlefsen, Sönke, additional, Juel, Helene Bæk, additional, Justesen, Ulrik Stenz, additional, Hansen, Torben, additional, Krag, Aleksander, additional, Thiele, Maja, additional, Anastasiadou, Ema, additional, Arumugam, Manimozhian, additional, Bork, Peer, additional, Presto, Jenny, additional, Israelsen, Hans, additional, Karsdal, Morten, additional, Legido-Quigley, Cristina, additional, Melberg, Hans Olav, additional, Trebicka, Jonel, additional, Mann, Mathias, additional, and Matthijnssens, Jelle, additional

Published
2024
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18. Onchocerciasis-associated epilepsy: an explorative case-control study with viral metagenomic analyses on Onchocerca volvulus

Author

Hadermann, Amber, primary, Jada, Stephen Raimon, additional, Sebit, Wilson J., additional, Deng, Thomas, additional, Bol, Yak Y., additional, Siewe Fodjo, Joseph N., additional, De Coninck, Lander, additional, Matthijnssens, Jelle, additional, Mertens, Inge, additional, Polman, Katja, additional, and Colebunders, Robert, additional

Published
2023
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19. Molecular Epidemiology of Rotavirus A in Calves: Evolutionary Analysis of a Bovine G8P[11] Strain and Spatio-Temporal Dynamics of G6 Lineages in the Americas

Author

Louge Uriarte, Enrique L., primary, Badaracco, Alejandra, additional, Spetter, Maximiliano J., additional, Miño, Samuel, additional, Armendano, Joaquín I., additional, Zeller, Mark, additional, Heylen, Elisabeth, additional, Späth, Ernesto, additional, Leunda, María Rosa, additional, Moreira, Ana Rita, additional, Matthijnssens, Jelle, additional, Parreño, Viviana, additional, and Odeón, Anselmo C., additional

Published
2023
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23. Metagenomics in Virology

Author

Roux, Simon, Matthijnssens, Jelle, and Dutilh, Bas E

Subjects
Vaccine Related, Infectious Diseases, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being
Abstract

Metagenomics, i.e., the sequencing and analysis of genomic information extracted directly from clinical or environmental samples, has become a fundamental tool to explore the viral world. Against the background of an extensive viral diversity revealed by metagenomics across many environments, new sequence assembly approaches that reconstruct complete genome sequences from metagenomes have recently revealed surprisingly cosmopolitan viruses in specific ecological niches. Metagenomics is also applied to clinical samples as a non-targeted diagnostic and surveillance tool. By enabling the study of these uncultivated viruses, metagenomics provides invaluable insights into the virus-host interactions, epidemiology, ecology, and evolution of viruses across all ecosystems.

Published
2021

24. STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Author

Boudewijns, Robbert, Thibaut, Hendrik Jan, Kaptein, Suzanne J. F., Li, Rong, Vergote, Valentijn, Seldeslachts, Laura, Van Weyenbergh, Johan, De Keyzer, Carolien, Bervoets, Lindsey, Sharma, Sapna, Liesenborghs, Laurens, Ma, Ji, Jansen, Sander, Van Looveren, Dominique, Vercruysse, Thomas, Wang, Xinyu, Jochmans, Dirk, Martens, Erik, Roose, Kenny, De Vlieger, Dorien, Schepens, Bert, Van Buyten, Tina, Jacobs, Sofie, Liu, Yanan, Martí-Carreras, Joan, Vanmechelen, Bert, Wawina-Bokalanga, Tony, Delang, Leen, Rocha-Pereira, Joana, Coelmont, Lotte, Chiu, Winston, Leyssen, Pieter, Heylen, Elisabeth, Schols, Dominique, Wang, Lanjiao, Close, Lila, Matthijnssens, Jelle, Van Ranst, Marc, Compernolle, Veerle, Schramm, Georg, Van Laere, Koen, Saelens, Xavier, Callewaert, Nico, Opdenakker, Ghislain, Maes, Piet, Weynand, Birgit, Cawthorne, Christopher, Vande Velde, Greetje, Wang, Zhongde, Neyts, Johan, and Dallmeier, Kai

Published
2020
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26. Foundation of the Belgian Society for Viruses of Microbes and Meeting Report of Its Inaugural Symposium

Author

Latka, Agnieszka, primary, Aertsen, Abram, additional, Boeckaerts, Dimitri, additional, Blasdel, Bob, additional, Ceyssens, Pieter-Jan, additional, Garcia-Pino, Abel, additional, Gillis, Annika, additional, Lavigne, Rob, additional, Lima-Mendez, Gipsi, additional, Matthijnssens, Jelle, additional, Onsea, Jolien, additional, Peeters, Eveline, additional, Pirnay, Jean-Paul, additional, Thiry, Damien, additional, Vandenheuvel, Dieter, additional, Van Mechelen, Els, additional, Venneman, Jolien, additional, Verbeken, Gilbert, additional, Wagemans, Jeroen, additional, and Briers, Yves, additional

Published
2023
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28. Sphingolipids Are Depleted in Alcohol-Related Liver Fibrosis

Author

Thiele, Maja, Suvitaival, Tommi, Trošt, Kajetan, Kim, Min, de Zawadzki, Andressa, Kjaergaard, Maria, Rasmussen, Ditlev Nytoft, Lindvig, Katrine Prier, Israelsen, Mads, Detlefsen, Sönke, Andersen, Peter, Juel, Helene Bæk, Nielsen, Trine, Georgiou, Stella, Filippa, Vicky, Kuhn, Michael, Nishijima, Suguru, Moitinho-Silva, Lucas, Rossing, Peter, Trebicka, Jonel, Anastasiadou, Ema, Bork, Peer, Hansen, Torben, Legido-Quigley, Cristina, Krag, Aleksander, Mann, Mathias, Matthijnssens, Jelle, Arumugam, Manimozhiyan, Henrar, Roland, Israelsen, Hans, Karsdal, Morten, Melberg, Hans Olav, Thiele, Maja, Suvitaival, Tommi, Trošt, Kajetan, Kim, Min, de Zawadzki, Andressa, Kjaergaard, Maria, Rasmussen, Ditlev Nytoft, Lindvig, Katrine Prier, Israelsen, Mads, Detlefsen, Sönke, Andersen, Peter, Juel, Helene Bæk, Nielsen, Trine, Georgiou, Stella, Filippa, Vicky, Kuhn, Michael, Nishijima, Suguru, Moitinho-Silva, Lucas, Rossing, Peter, Trebicka, Jonel, Anastasiadou, Ema, Bork, Peer, Hansen, Torben, Legido-Quigley, Cristina, Krag, Aleksander, Mann, Mathias, Matthijnssens, Jelle, Arumugam, Manimozhiyan, Henrar, Roland, Israelsen, Hans, Karsdal, Morten, and Melberg, Hans Olav

Abstract

Background & Aims: Alcohol disturbs hepatic lipid synthesis and transport, but the role of lipid dysfunction in alcohol-related liver disease (ALD) is unclear. In this biopsy-controlled, prospective, observational study, we characterized the liver and plasma lipidomes in patients with early ALD. Methods: We performed mass spectrometry–based lipidomics of paired liver and plasma samples from 315 patients with ALD and of plasma from 51 matched healthy controls. We associated lipid levels with histologic fibrosis, inflammation, and steatosis with correction for multiple testing and adjustment for confounders. We further investigated sphingolipid regulation by means of quantitative real-time polymerase chain reaction sequencing of microRNA, prediction of liver-related events, and tested causality with Mendelian randomization. Results: We detected 198 lipids in the liver and 236 lipids in the circulation from 18 lipid classes. Most sphingolipids (sphingomyelins and ceramides) and phosphocholines were co–down-regulated in both liver and plasma, where lower abundance correlated with higher fibrosis stage. Sphingomyelins showed the most pronounced negative correlation to fibrosis, mirrored by negative correlations in both liver and plasma with hepatic inflammation. Reduced sphingomyelins predicted future liver-related events. This seemed to be characteristic of “pure ALD,” as sphingomyelin levels were higher in patients with concomitant metabolic syndrome and ALD/nonalcoholic fatty liver disease overlap. Mendelian randomization in FinnGen and UK Biobanks indicated ALD as the cause of low sphingomyelins, and alcohol use disorder did not correlate with genetic susceptibility to low sphingomyelin levels. Conclusions: Alcohol-related liver fibrosis is characterized by selective and progressive lipid depletion in liver and blood, particularly sphingomyelins, which also associates with progression to liver-related events.

Published
2023

29. Foundation of the Belgian Society for Viruses of Microbes and Meeting Report of Its Inaugural Symposium

Author

Latka, Agnieszka, Aertsen, Abram, Boeckaerts, Dimitri, Blasdel, Bob B.G., Ceyssens, Pieter-Jan, Garcia-Pino, Abel, Gillis, Annika, Lavigne, Rob, Lima Mendez, Gipsi, Matthijnssens, Jelle, Onsea, Jolien, Peeters, Eveline, Pirnay, Jean-Paul, Thiry, Damien, Vandenheuvel, Dieter, Van Mechelen, Els, Venneman, Jolien, Verbeken, Gilbert, Wagemans, Jeroen, Briers, Yves, Latka, Agnieszka, Aertsen, Abram, Boeckaerts, Dimitri, Blasdel, Bob B.G., Ceyssens, Pieter-Jan, Garcia-Pino, Abel, Gillis, Annika, Lavigne, Rob, Lima Mendez, Gipsi, Matthijnssens, Jelle, Onsea, Jolien, Peeters, Eveline, Pirnay, Jean-Paul, Thiry, Damien, Vandenheuvel, Dieter, Van Mechelen, Els, Venneman, Jolien, Verbeken, Gilbert, Wagemans, Jeroen, and Briers, Yves

Abstract

The Belgian Society for Viruses of Microbes (BSVoM) was founded on 9 June 2022 to capture and enhance the collaborative spirit among the expanding community of microbial virus researchers in Belgium. The sixteen founders are affiliated to fourteen different research entities across academia, industry and government. Its inaugural symposium was held on 23 September 2022 in the Thermotechnical Institute at KU Leuven. The meeting program covered three thematic sessions launched by international keynote speakers: (1) virus–host interactions, (2) viral ecology, evolution and diversity and (3) present and future applications. During the one-day symposium, four invited keynote lectures, ten selected talks and eight student pitches were given along with 41 presented posters. The meeting hosted 155 participants from twelve countries., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

30. Use of Next-Generation Sequencing for Diagnosis of West Nile Virus Infection in Patient Returning to Belgium from Hungary

Author

Wollants, Elke, Smolders, David, Naesens, Reinout, Bruynseels, Peggy, Lagrou, Katrien, Matthijnssens, Jelle, and Van Ranst, Marc

Subjects
High-throughput screening (Biochemical assaying) -- Usage, West Nile fever -- Risk factors -- Genetic aspects, Elderly patients -- Health aspects -- Genetic aspects, Health
Abstract

West Nile virus (WNV) is a widespread reemerging global pathogen. Mosquito bites are the source for nearly all human infections. These infections usually remain asymptomatic; only 20%-40% of infected persons [...]

Published
2018

33. ICTV Virus Taxonomy Profile: Spinareoviridae 2022

Author

Matthijnssens, Jelle, Attoui, Houssam, Bányai, Krisztián, Brussaard, Corina PD, Danthi, Pranav, Del Vas, Mariana, Dermody, Terence S, Duncan, Roy, Fāng, Qín, Johne, Reimar, Mertens, Peter PC, Mohd Jaafar, Fauziah, Patton, John T, Sasaya, Takahide, Suzuki, Nobuhiro, and Wei, Taiyun

Subjects
Reovirales, taxonomy, Virology, Fungi, Spinareoviridae, Animals, Humans, Plants, ICTV report, Host Specificity, Phylogeny, RNA, Double-Stranded
Abstract

Spinareoviridae is a large family of icosahedral viruses that are usually regarded as non-enveloped with segmented (9–12 linear segments) dsRNA genomes of 23–29 kbp. Spinareovirids have a broad host range, infecting animals, fungi and plants. Some have important pathogenic potential for humans (e.g. Colorado tick fever virus), livestock (e.g. avian orthoreoviruses), fish (e.g. aquareoviruses) and plants (e.g. rice ragged stunt virus and rice black streaked dwarf virus). This is a summary of the ICTV Report on the family Spinareoviridae, which is available at ictv.global/report/spinareoviridae.

Published
2022

34. Bidirectional Interactions between Arboviruses and the Bacterial and Viral Microbiota in Aedes aegypti and Culex quinquefasciatus

Author

Shi, Chenyan, primary, Beller, Leen, additional, Wang, Lanjiao, additional, Rosales Rosas, Ana, additional, De Coninck, Lander, additional, Héry, Lyza, additional, Mousson, Laurence, additional, Pagès, Nonito, additional, Raes, Jeroen, additional, Delang, Leen, additional, Vega-Rúa, Anubis, additional, Failloux, Anna-bella, additional, and Matthijnssens, Jelle, additional

Published
2022
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37. Bidirectional Interactions between Arboviruses and the Bacterial and Viral Microbiota in Aedes aegypti and Culex quinquefasciatus

Author

Shi, Chenyan, Beller, Leen, Wang, Lanjiao, Rosales Rosas, Ana, De Coninck, Lander, Héry, Lyza, Mousson, Laurence, Pagès, Nonito, Raes, Jeroen, Delang, Leen, Vega-Rúa, Anubis, Failloux, Anna-Bella, Matthijnssens, Jelle, Shi, Chenyan, Beller, Leen, Wang, Lanjiao, Rosales Rosas, Ana, De Coninck, Lander, Héry, Lyza, Mousson, Laurence, Pagès, Nonito, Raes, Jeroen, Delang, Leen, Vega-Rúa, Anubis, Failloux, Anna-Bella, and Matthijnssens, Jelle

Abstract

Mosquitoes are important vectors for many arboviruses. It is becoming increasingly clear that various symbiotic microorganisms (including bacteria and insect-specific viruses; ISVs) in mosquitoes have the potential to modulate the ability of mosquitoes to transmit arboviruses. In this study, we compared the bacteriome and virome (both eukaryotic viruses and bacteriophages) of female adult Aedes aegypti and Culex quinquefasciatus mosquitoes fed with sucrose/water, blood, or blood spiked with Zika virus (ZIKV) or West Nile virus (WNV), respectively. Furthermore, we investigated associations between the microbiota and vector competence. We show that the influence of arboviruses on the mosquito microbiome—and vice versa—is distinct for each combination of arbovirus/mosquito species. The presence of ZIKV resulted in a temporarily increased Aedes ISV diversity. However, this effect was distinct for different ISVs: some ISVs decreased following the blood meal (Aedes aegypti totivirus), whereas other ISVs increased only when the blood contained ZIKV (Guadeloupe mosquito virus). Also, the diversity of the Aedes bacteriome depended on the diet and the presence of ZIKV, with a lower diversity observed for mosquitoes receiving blood without ZIKV. In Cx. quinquefasciatus, some ISVs increased in WNV-infected mosquitoes (Guadeloupe Culex tymo-like virus). Particularly, the presence of Wenzhou sobemo-like virus 3 (WSLV3) was associated with the absence of infectious WNV in mosquito heads, suggesting that WSLV3 might affect vector competence for WNV. Distinct profiles of bacteriophages were identified in Culex mosquitoes depending on diet, despite the lack of clear changes in the bacteriome. Overall, our data demonstrate a complex three-way interaction among arboviruses, resident microbiota, and the host, which is distinct for different arbovirus–mosquito combinations. A better understanding of these interactions may lead to the identification of microbiota able to suppress the abil

Published
2022

38. Molecular characterization of the gastrointestinal eukaryotic virome in elderly people in Belem, Para, Brazil

Author

Portal, Thayara Morais, primary, Vanmechelen, Bert, additional, Van Espen, Lore, additional, Jansen, Daan, additional, Teixeira, Dielle Monteiro, additional, de Sousa, Emanuella Sarmento Alho, additional, da Silva, Victor Pereira, additional, de Lima, Juliana Silva, additional, Reymão, Tammy Katlhyn Amaral, additional, Sequeira, Carina Guilhon, additional, da Silva Ventura, Ana Maria Revorêdo, additional, da Silva, Luciana Damascena, additional, Resque, Hugo Reis, additional, Matthijnssens, Jelle, additional, and Gabbay, Yvone Benchimol, additional

Published
2022
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39. The virota and its transkingdom interactions in the healthy infant gut

Author

Beller, Leen, primary, Deboutte, Ward, additional, Vieira-Silva, Sara, additional, Falony, Gwen, additional, Tito, Raul Yhossef, additional, Rymenans, Leen, additional, Yinda, Claude Kwe, additional, Vanmechelen, Bert, additional, Van Espen, Lore, additional, Jansen, Daan, additional, Shi, Chenyan, additional, Zeller, Mark, additional, Maes, Piet, additional, Faust, Karoline, additional, Van Ranst, Marc, additional, Raes, Jeroen, additional, and Matthijnssens, Jelle, additional

Published
2022
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40. Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970's Egypt

Author

Rodrigues De Miranda, Joachim, Brettell, Laura E., Chejanovsky, Nor, Childers, Anna K., Dalmon, Anne, Deboutte, Ward, de Graaf, Dirk C., Doublet, Vincent, Gebremedhn, Haftom, Genersch, Elke, Gisder, Sebastian, Granberg, Fredrik, Haddad, Nizar J., Manley, Robyn, Matthijnssens, Jelle, Meeus, Ivan, Migdadi, Hussein, Milbrath, Meghan, Mondet, Fanny, Remnant, Emily J., Roberts, John M. K., Ryabov, Eugene, Sela, Noa, Smagghe, Guy, Somanathan, Hema, Wilfert, Lena, Wright, Owen N., Martin, Stephen J., and Ball, Brenda

Subjects
Ecology
Abstract

In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes.

Published
2022

41. Additional file 1 of Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt

Author

de Miranda, Joachim R., Brettell, Laura E., Chejanovsky, Nor, Childers, Anna K., Dalmon, Anne, Deboutte, Ward, de Graaf, Dirk C., Doublet, Vincent, Gebremedhn, Haftom, Genersch, Elke, Gisder, Sebastian, Granberg, Fredrik, Haddad, Nizar J., Kaden, Rene, Manley, Robyn, Matthijnssens, Jelle, Meeus, Ivan, Migdadi, Hussein, Milbrath, Meghan O., Mondet, Fanny, Remnant, Emily J., Roberts, John M. K., Ryabov, Eugene V., Sela, Noa, Smagghe, Guy, Somanathan, Hema, Wilfert, Lena, Wright, Owen N., Martin, Stephen J., and Ball, Brenda V.

Abstract

Additional file 1: Figure S1. Amplification and sequencing strategy. Figure S2. MENA polymorphisms. Table S1. Primers for amplifying DWV strains. Table S2. Numerical details of the phylogenetic analyses. Table S3. SRA libraries and samples screened for DWV-D.

Published
2022
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42. The Virome of Healthy Honey Bee Colonies: Ubiquitous Occurrence of Known and New Viruses in Bee Populations

Author

Kadlečková, Dominika, Tachezy, Ruth, Erban, Tomáš, Deboutte, Ward, Nunvář, Jaroslav, Saláková, Martina, and Matthijnssens, Jelle

Subjects
PATHOGENS, metagenomics, Science & Technology, Physiology, TRANSMISSION, MORTALITY, Picornavirales, Lake Sinai virus, Biochemistry, Microbiology, Computer Science Applications, ALIGNMENT, PARALYSIS VIRUS, VARROA, Modeling and Simulation, Genetics, viruses, Apis mellifera, DEFORMED WING VIRUS, rhabdovirus, Molecular Biology, Life Sciences & Biomedicine, Ecology, Evolution, Behavior and Systematics
Abstract

Honey bees are globally important pollinators threatened by many different pathogens, including viruses. We investigated the virome of honey bees collected at the end of the beekeeping season (August/September) in Czechia, a Central European country. Samples were examined in biological replicates to assess the homogeneity, stability, and composition of the virome inside a single hive. By choice of healthy workers from colonies, where Varroa destructor was under control, we could identify ubiquitous bee viruses. Deformed wing virus (DWV) was highly prevalent, even though the bees were healthy, without any noticeable disease signs. The overall virome composition (consisting of honey bee-, plant-, and bacterium-infecting viruses) was driven primarily by the hive and its location. However, honey bee-specific viruses showed an uneven distribution within the same hive. In addition, our results point to an unusual cooccurrence between two rhabdoviruses and reveal the presence of five distinct lineages of Lake Sinai viruses (LSVs) clustering with other LSV strains described globally. Comparison of our results with the virome of Australian honey bees, the last truly Varroa- and DWV-free population, showed a strong difference with respect to DWV and a set of diverse members of the Picornavirales, of which the latter were absent in our samples. We hypothesize that the occurrence of DWV introduced by Varroa strongly affects the virome structure despite the mite being under control. IMPORTANCE The Western honey bee, Apis mellifera, is a vital part of our ecosystem as well as cultural heritage. Annual colony losses endanger beekeeping. In this study, we examined healthy bees from the heart of Central Europe, where honey bee colonies have been commonly affected by varroosis over 5 decades. Our virome analysis showed the presence of ubiquitous viruses in colonies where the mite Varroa destructor was under control and no honey bee disease signs were observed. Compared to previous studies, an important part of our study was the analysis of multiple replicates from individual hives. Our overall results indicate that the virome structure (including bee-infecting viruses, plant-infecting viruses, and bacteriophages) is stable within hives; however, the bee-infecting viruses varied largely within interhive replicates, suggesting variation of honey bee viruses within individual bees. Of interest was the striking difference between the viromes of our 39 pools and 9 pools of honey bee viromes previously analyzed in Australia. It could be suggested that Varroa not only affects DWV spread in bee colonies but also affects diverse members of the Picornavirales, which were strongly decreased in Czech bees compared to the Varroa- and DWV-naive Australian bees. ispartof: MSYSTEMS vol:7 issue:3 ispartof: location:United States status: published

Published
2022

43. Successional Stages in Infant Gut Microbiota Maturation

Author

Beller, Leen, primary, Deboutte, Ward, additional, Falony, Gwen, additional, Vieira-Silva, Sara, additional, Tito, Raul Yhossef, additional, Valles-Colomer, Mireia, additional, Rymenans, Leen, additional, Jansen, Daan, additional, Van Espen, Lore, additional, Papadaki, Maria Ioanna, additional, Shi, Chenyan, additional, Yinda, Claude Kwe, additional, Zeller, Mark, additional, Faust, Karoline, additional, Van Ranst, Marc, additional, Raes, Jeroen, additional, and Matthijnssens, Jelle, additional

Published
2021
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46. Widespread rotavirus H in domesticated pigs, United States

Author

Marthaler, Douglas, Rossow, Kurt, Culhane, Marie, Goyal, Sagar, Collins, Jim, Matthijnssens, Jelle, Nelson, Martha, and Ciarlet, Max

Subjects
Medical research, Medicine, Experimental, Swine -- Diseases, Disease transmission -- Research, Rotavirus infections -- Distribution, Company distribution practices, Health
Abstract

Rotaviruses (RVs) belong to the Reoviridae family and are a major cause of severe diarrhea in humans and animals worldwide (1). According to the International Committee on Taxonomy of Viruses, [...]

Published
2014
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47. A Previously Undescribed Highly Prevalent Phage Identified in a Danish Enteric Virome Catalog

Author

Van Espen, Lore, primary, Bak, Emilie Glad, additional, Beller, Leen, additional, Close, Lila, additional, Deboutte, Ward, additional, Juel, Helene Bæk, additional, Nielsen, Trine, additional, Sinar, Deniz, additional, De Coninck, Lander, additional, Frithioff-Bøjsøe, Christine, additional, Fonvig, Cilius Esmann, additional, Jacobsen, Suganya, additional, Kjærgaard, Maria, additional, Thiele, Maja, additional, Fullam, Anthony, additional, Kuhn, Michael, additional, Holm, Jens-Christian, additional, Bork, Peer, additional, Krag, Aleksander, additional, Hansen, Torben, additional, Arumugam, Manimozhiyan, additional, and Matthijnssens, Jelle, additional

Published
2021
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48. Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance

Author

Van Dycke, Jana, primary, Puxeddu, Michela, additional, La Regina, Giuseppe, additional, Mastrangelo, Eloise, additional, Tarantino, Delia, additional, Rymenants, Jasper, additional, Sebastiani, Jessica, additional, Nalli, Marianna, additional, Matthijnssens, Jelle, additional, Neyts, Johan, additional, Silvestri, Romano, additional, and Rocha-Pereira, Joana, additional

Published
2021
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49. Near-complete genome sequences of eight human astroviruses recovered from diarrheal stool samples of hospitalized children in coastal Kenya in 2019

Author

Lambisia, Arnold W., Phan, My V. T., de Laurent, Zaydah R., Cotten, Matthew, Nokes, D. James, Agoti, Charles N., and Matthijnssens, Jelle

Abstract

Here, using a sequence-independent sequencing approach (M. V. Phan, P. Hong Anh, N. Van Cuong, B. Oude Munnink, et al., Virus Evol 2:vew027, 2016, https://doi.org/10.1093/ve/vew027), we determined human astrovirus (HAstV) genome sequences from eight diarrheal stool samples collected in coastal Kenya in 2019. Phylogenetic analysis identified the following 4 genotypes: HAstV-1 (n = 4), HAstV-2 (n = 1), HAstV-3 (n = 1), and HAstV-5 (n = 2).

Published
2021

50. Feline origin of rotavirus strain, Tunisia, 2008

Author

Fredj, Mouna Ben Hadj, Heylen, Elisabeth, Zeller, Mark, Fodha, Imene, Benhamida-Rebai, Meriam, Van Ranst, Marc, Matthijnssens, Jelle, and Trabelsi, Abdelhalim

Subjects
Gastroenteritis -- Analysis -- Causes of -- Genetic aspects -- Research, Disease transmission -- Control -- Research, Rotaviruses -- Health aspects -- Genetic aspects -- Research, Health
Abstract

Group A rotaviruses (RVAs) are a leading cause of severe acute gastroenteritis in infants and young children. An infectious RVA virion is a triple-layered icosahedral particle that contains 11 segments [...]

Published
2013
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