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4. A Two-course Survey of "Creative Country"

Author

Matthews, John B.

Subjects
CREATIVE ability in business, BUSINESS, EXECUTIVE ability (Management), OCCUPATIONAL training, INDUSTRIAL advertising, CHIEF executive officers, ADVERTISING effectiveness, INNOVATIONS in business, CREATIVE thinking, TRAINING, MARKETING
Abstract

This article is adapted from a chapter on creativity in a forthcoming book which is not about the business of advertising, but which deals with the advertising of business. Titled "The Chief Executive's Journal of Capitalistic Advertising," the book presents a most timely concept of advertising, and one which gives the Chief Executive definite responsibilities. As a student of creativity, a Chief Executive needs a grasp of the fundamentals not unlike that of a college sophomore taking Creativity 101. This article aims to provide just that. [ABSTRACT FROM AUTHOR]

Published
1975
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5. Letters to the editor.

Author

Goldman, Marshall I., Perkins, Courtland D., Olasky, Marvin N., Kime, Milford B., Cassidy, Frank D., Field, Francis E., Merrifield, D. Bruce, Branscomb, Lewis M., Schwarz, Anton J., Haas, Ward J., Hawkins, Willis M., Caporali, Renso L., White, George R., Graybill, W. B., MacIntyre, Alasdair, Goodpaster, Kenneth E., Matthews, John B., Dobson, John L., Moss, Rose, and Glowacz, James

Subjects
LETTERS to the editor, TECHNOLOGY, CAPITALISM, NEW product development, CONSUMERS
Abstract

The article presents several letters to the editor in response to articles in previous issues including "Tapping Eastern Bloc Technology," by John Kiser III in the March-April 1982 issue, "The Moral Crisis in American Capitalism," by Robert Wuthnow in the March-April 1982 issue, and "Get New Products from Customers," by Eric von Hippel in the March-April 1982 issue.

Published
1982

6. Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant

Author

Dias, Irundika H.K., Marshall, Lindsay, Lambert, Peter A., Chapple, Iain L.C., Matthews, John B., and Griffiths, Helen R.

Abstract

Porphyromonas gingivalis, a gram-negative anaerobe which is implicated in the etiology of active periodontitis, secretes degradative enzymes (gingipains) and sheds proinflammatory mediators (e.g., lipopolysaccharides [LPS]). LPS triggers the secretion of interleukin-8 (IL-8) from immune (72-amino-acid [aa] variant [IL-8(72aa)]) and nonimmune (IL-8(77aa)) cells. IL-8(77aa) has low chemotactic and respiratory burst-inducing activity but is susceptible to cleavage by gingipains. This study shows that both R- and K-gingipain treatments of IL-8(77aa) significantly enhance burst activation by fMLP and chemotactic activity (P < 0.05) but decrease burst activation and chemotactic activity of IL-8(72aa) toward neutrophil-like HL60 cells and primary neutrophils (P < 0.05). Using tandem mass spectrometry, we have demonstrated that R-gingipain cleaves 5- and 11-aa peptides from the N-terminal portion of IL-8(77aa) and the resultant peptides are biologically active, while K-gingipain removes an 8-aa N-terminal peptide yielding a 69-aa isoform of IL-8 that shows enhanced biological activity. During periodontitis, secreted gingipains may differentially affect neutrophil chemotaxis and activation in response to IL-8 according to the cellular source of the chemokine.

Published
2008

7. Can a corporation have a conscience?

Author

Goodpaster, Kenneth E., Matthews, John B., Jr., Drucker, Peter F., Silk, Leonard, Stone, Christopher, and Nozick, Robert

Subjects
Industrial management, Business ethics -- Analysis, Corporations -- Social policy, Business, Business, general
Published
1982

8. Proteomic analysis of a noninvasive human model of acute inflammation and its resolution:the twenty-one day gingivitis model

Author

Grant, Melissa M., Creese, Andrew J., Barr, Gordon, Ling, Martin R., Scott, Ann E., Matthews, John B., Griffiths, Helen R, Cooper, Helen J., Chapple, Iain L.C., Grant, Melissa M., Creese, Andrew J., Barr, Gordon, Ling, Martin R., Scott, Ann E., Matthews, John B., Griffiths, Helen R, Cooper, Helen J., and Chapple, Iain L.C.

Abstract

The 21-day experimental gingivitis model, an established noninvasive model of inflammation in response to increasing bacterial accumulation in humans, is designed to enable the study of both the induction and resolution of inflammation. Here, we have analyzed gingival crevicular fluid, an oral fluid comprising a serum transudate and tissue exudates, by LC-MS/MS using Fourier transform ion cyclotron resonance mass spectrometry and iTRAQ isobaric mass tags, to establish meta-proteomic profiles of inflammation-induced changes in proteins in healthy young volunteers. Across the course of experimentally induced gingivitis, we identified 16 bacterial and 186 human proteins. Although abundances of the bacterial proteins identified did not vary temporally, Fusobacterium outer membrane proteins were detected. Fusobacterium species have previously been associated with periodontal health or disease. The human proteins identified spanned a wide range of compartments (both extracellular and intracellular) and functions, including serum proteins, proteins displaying antibacterial properties, and proteins with functions associated with cellular transcription, DNA binding, the cytoskeleton, cell adhesion, and cilia. PolySNAP3 clustering software was used in a multilayered analytical approach. Clusters of proteins that associated with changes to the clinical parameters included neuronal and synapse associated proteins.

Published
2010

9. Williams, Niall. History of the Rain

Author

Matthews, John B.

Subjects
History of the Rain (Novel) -- Williams, Niall -- Book reviews, Books -- Book reviews, Library and information science
Abstract

* Williams, Niall. History of the Rain. Bloomsbury USA. Apr. 2014. 366p. ISBN 9781620406472. $26; ebk. ISBN 9781620406469. F In the tiny Irish village of Faha, college student Ruthie Swain [...]

Published
2014

13. Gingipains from Porphyromonas gingivalisIncrease the Chemotactic and Respiratory Burst-Priming Properties of the 77-Amino-Acid Interleukin-8 Variant

Author

Dias, Irundika H. K., Marshall, Lindsay, Lambert, Peter A., Chapple, Iain L. C., Matthews, John B., and Griffiths, Helen R.

Abstract

ABSTRACTPorphyromonas gingivalis, a gram-negative anaerobe which is implicated in the etiology of active periodontitis, secretes degradative enzymes (gingipains) and sheds proinflammatory mediators (e.g., lipopolysaccharides [LPS]). LPS triggers the secretion of interleukin-8 (IL-8) from immune (72-amino-acid [aa] variant [IL-872aa]) and nonimmune (IL-877aa) cells. IL-877aahas low chemotactic and respiratory burst-inducing activity but is susceptible to cleavage by gingipains. This study shows that both R- and K-gingipain treatments of IL-877aasignificantly enhance burst activation by fMLP and chemotactic activity (P< 0.05) but decrease burst activation and chemotactic activity of IL-872aatoward neutrophil-like HL60 cells and primary neutrophils (P< 0.05). Using tandem mass spectrometry, we have demonstrated that R-gingipain cleaves 5- and 11-aa peptides from the N-terminal portion of IL-877aaand the resultant peptides are biologically active, while K-gingipain removes an 8-aa N-terminal peptide yielding a 69-aa isoform of IL-8 that shows enhanced biological activity. During periodontitis, secreted gingipains may differentially affect neutrophil chemotaxis and activation in response to IL-8 according to the cellular source of the chemokine.

Published
2008
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14. Power and morality

Author

Matthews, John B.

Subjects
Power And Morality (Book) -- Book reviews, Books, Business, Business, general, History
Published
1981

17. Moving the Better Mousetrap

Author

Flinn, William A., primary, Matthews, John B., additional, Buzzell, Robert, additional, Levitt, Theodore, additional, and Frank, Ronald E., additional

Published
1965
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20. More and Better Cases

Author

Brunner, James A., primary, Brown, Milton P., additional, England, Wilbur B., additional, and Matthews, John B., additional

Published
1962
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21. Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant.

Author

Dias IH, Marshall L, Lambert PA, Chapple IL, Matthews JB, and Griffiths HR

Subjects
Gene Expression, Gingipain Cysteine Endopeptidases, HL-60 Cells, Humans, Neutrophil Activation, Neutrophils drug effects, Neutrophils metabolism, Adhesins, Bacterial pharmacology, Chemotaxis physiology, Cysteine Endopeptidases pharmacology, Interleukin-8 genetics, Interleukin-8 metabolism, Porphyromonas gingivalis metabolism, Respiratory Burst physiology
Abstract

Porphyromonas gingivalis, a gram-negative anaerobe which is implicated in the etiology of active periodontitis, secretes degradative enzymes (gingipains) and sheds proinflammatory mediators (e.g., lipopolysaccharides [LPS]). LPS triggers the secretion of interleukin-8 (IL-8) from immune (72-amino-acid [aa] variant [IL-8(72aa)]) and nonimmune (IL-8(77aa)) cells. IL-8(77aa) has low chemotactic and respiratory burst-inducing activity but is susceptible to cleavage by gingipains. This study shows that both R- and K-gingipain treatments of IL-8(77aa) significantly enhance burst activation by fMLP and chemotactic activity (P < 0.05) but decrease burst activation and chemotactic activity of IL-8(72aa) toward neutrophil-like HL60 cells and primary neutrophils (P < 0.05). Using tandem mass spectrometry, we have demonstrated that R-gingipain cleaves 5- and 11-aa peptides from the N-terminal portion of IL-8(77aa) and the resultant peptides are biologically active, while K-gingipain removes an 8-aa N-terminal peptide yielding a 69-aa isoform of IL-8 that shows enhanced biological activity. During periodontitis, secreted gingipains may differentially affect neutrophil chemotaxis and activation in response to IL-8 according to the cellular source of the chemokine.

Published
2008
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