Search

Your search keyword '"Marrazzo, Antonio"' showing total 34 results
Start Over Author "Marrazzo, Antonio" Search Limiters Full Text
34 results on '"Marrazzo, Antonio"'

3. Vascular lesions of the pediatric orbit: A radiological walkthrough

Author

Colafati, Giovanna Stefania, primary, Piccirilli, Eleonora, additional, Marrazzo, Antonio, additional, Carboni, Alessia, additional, Diociaiuti, Andrea, additional, El Hachem, May, additional, Esposito, Francesco, additional, Zama, Mario, additional, Rollo, Massimo, additional, Gandolfo, Carlo, additional, and Tomà, Paolo, additional

Published
2022
Full Text
View/download PDF

5. Rethinking the Management of Optic Pathway Gliomas: A Single Center Experience

Author

Del Baldo, Giada, primary, Cacchione, Antonella, additional, Dell’Anna, Vito Andrea, additional, Merli, Pietro, additional, Colafati, Giovanna Stefania, additional, Marrazzo, Antonio, additional, Rossi, Sabrina, additional, Giovannoni, Isabella, additional, Barresi, Sabina, additional, Deodati, Annalisa, additional, Valente, Paola, additional, Ferretti, Elisabetta, additional, Capece, Mara, additional, Mastronuzzi, Angela, additional, and Carai, Andrea, additional

Published
2022
Full Text
View/download PDF

6. Flow-diverter treatment for renal artery aneurysms: One-year follow-up of a multicentric preliminary experience.

Author

Semeraro, Vittorio, Arpesani, Roberto, della Malva, Giuseppina, Gasparrini, Fulvio, Vidali, Sofia, Ganimede, Maria Porzia, Marrazzo, Antonio, Rosella, Francesco, Biraschi, Francesco, Gandini, Roberto, Burdi, Nicola, and Di Stasi, Carmine

Subjects
RENAL artery aneurysms, FOLLOW-up studies (Medicine), DISEASE incidence, THERAPEUTIC embolization, ANGIOGRAPHY
Abstract

PURPOSE Renal artery aneurysms (RAAs) are rare in the general population, although the true incidence and natural history remain elusive. Conventional endovascular therapies such as coil embolization or covered stent graft may cause side branches occlusion, leading to organ infarction. Flow diverters (FDs) have been first designed to treat cerebrovascular aneurysms, but their use may be useful to treat complex RAAs presenting side branches arising from the aneurysmal sac. We aimed to evaluate the mid-term follow-up (FUP) safety and efficacy of FDs during the treatment of complex RAAs. METHODS Between November 2019 and April 2020, 7 RAAs were identified in 7 patients (4 men, 3 women; age range 55-82 years; median 67 years) and treated by FDs. Procedural details, complications, morbidity and mortality, aneurysm occlusion, and segmental artery patency were retrospectively reviewed. Twelve months of computed tomography angiography (CTA) FUP was evaluated for all cases. RESULTS Deployment of FDs was successful in all cases. One intraprocedural technical complication was encountered with one FD felt down into aneurism sac which requiring additional telescopic stenting. One case at 3 months CTA FUP presented the same complication, requiring the same rescue technique. At 12 months CTA FUP, 5 cases of size shrinkage and 2 cases of stable size were documented. No rescue surgery or major intraprocedural or mid-term FUP complication was seen. CONCLUSION Complex RAAs with 2 or more side branches can be safely treated by FD. FD efficacy for RAA needs further validation at long-term FUP by additional large prospective studies. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

8. Synchronous Presentation of Rare Brain Tumors in Von Hippel–Lindau Syndrome

Author

Lodi, Mariachiara, primary, Marrazzo, Antonio, additional, Cacchione, Antonella, additional, Macchiaiolo, Marina, additional, Romanzo, Antonino, additional, Mastronardi, Luciano, additional, Diomedi-Camassei, Francesca, additional, Carboni, Alessia, additional, Carai, Andrea, additional, Gandolfo, Carlo, additional, Monti, Lidia, additional, Mastronuzzi, Angela, additional, and Colafati, Giovanna Stefania, additional

Published
2021
Full Text
View/download PDF

9. Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle: A Case of Relapse Treated with Proton Beam Therapy

Author

Cacchione, Antonella, primary, Mastronuzzi, Angela, additional, Carai, Andrea, additional, Colafati, Giovanna Stefania, additional, Diomedi-Camassei, Francesca, additional, Marrazzo, Antonio, additional, Carboni, Alessia, additional, Miele, Evelina, additional, Pedace, Lucia, additional, Tartaglia, Marco, additional, Amichetti, Maurizio, additional, Fellin, Francesco, additional, Lodi, Mariachiara, additional, and Vennarini, Sabina, additional

Published
2021
Full Text
View/download PDF

11. Orbito-facial dysmorphology in patients with different degrees of trigonocephaly severity: quantitative morpho-volumetric analysis in infants with non-syndromic metopic craniosynostosis

Author

Calandrelli, Rosalinda, Pilato, Fabio, Massimi, Luca, Marrazzo, Antonio, Panfili, M., Di Rocco, C., Colosimo, Cesare, Calandrelli R., Pilato F. (ORCID:0000-0002-7248-3916), Massimi L., Marrazzo A., Colosimo C. (ORCID:0000-0003-3800-3648), Calandrelli, Rosalinda, Pilato, Fabio, Massimi, Luca, Marrazzo, Antonio, Panfili, M., Di Rocco, C., Colosimo, Cesare, Calandrelli R., Pilato F. (ORCID:0000-0002-7248-3916), Massimi L., Marrazzo A., and Colosimo C. (ORCID:0000-0003-3800-3648)

Abstract

Purpose: Craniofacial dysmorphology varies significantly along a wide spectrum of severity in metopic cranial synostosis (MCS). This study aimed to quantify craniofacial changes, in MCS, to investigate their relationships with the severity of trigonocephaly. Methods: By combining the metopic ridge and interfrontal angles, we identified three groups of trigonocephaly severity (mild group n.14, moderate group n.19, severe group n.18). We perform a quantitative analysis using high-resolution CT images evaluating (1) cranial fossae dimensions; (2) vault indices and ratios: interparietal/ intercoronal (IPD/ICD), interparietal/intertemporal (IPD/ITD), cephalic index, vertico-longitudinal index; (3) orbito-facial distances (midfacial depth, maxillary height, upper facial index, orbital distances, globe protrusions), maxilla and orbital volumes; (4) supratentorial (ICV) and infratentorial (PCFV) cranial volumes and supratentorial (WBV) and infratentorial (PCFBV) brain volumes. Results: In all groups, middle skull base lengths and upper midface index were increased. In moderate and severe groups: anterior hemifossa lengths were reduced, IPD/ICD and vertico-longitudinal index were changed; midfacial depth, anterior, mild, and lateral interorbital distances were reduced; globe protrusions were increased. The comparison between moderate and severe groups showed an increase of both globe protrusions and IPD/ICD. Among all groups, ICV and WBV were reduced in the severe group. Conclusion: This morpho-volumetric study provides new insights in understanding the craniofacial changes occurring in infants at different severity of trigonocephaly. The increase of globe protrusions and the reduction of supratentorial volumes found in the severe group reflect the severity of trigonocephaly; these findings might have a clinical and surgical relevance.

Published
2020

12. Craniofacial Sutural Pattern and Surgical Management in Patients With Different Degrees of Trigonocephaly Severity

Author

Calandrelli, Rosalinda, Pilato, Fabio, Massimi, Luca, Panfili, M., Marrazzo, Antonio, Di Rocco, C., Colosimo, Cesare, Calandrelli R., Pilato F. (ORCID:0000-0002-7248-3916), Massimi L., Marrazzo A., Colosimo C. (ORCID:0000-0003-3800-3648), Calandrelli, Rosalinda, Pilato, Fabio, Massimi, Luca, Panfili, M., Marrazzo, Antonio, Di Rocco, C., Colosimo, Cesare, Calandrelli R., Pilato F. (ORCID:0000-0002-7248-3916), Massimi L., Marrazzo A., and Colosimo C. (ORCID:0000-0003-3800-3648)

Abstract

The aim of this study was to identify quantitative tools to classify the severity of trigonocephaly to guide surgical management and predict outcome. METHODS: We reviewed high-resolution computed tomography images of 59 patients with metopic synostosis. We assessed the craniofacial sutural pattern as well as interfrontal and metopic angles, and we related the frontal angulation degree with the sutural pattern, the surgical management, and clinical outcome. RESULTS: We identified 3 groups according to the severity of trigonocephaly. No difference was found between the sutural pattern of nasion complex and severity, whereas the closure of zygomatic maxillary sutures increased with the severity degree (P < 0.05). The operative management was related to the severity degree (P < 0.001) and to the reduced age (P = 0.009). CONCLUSIONS: Interfrontal and metopic angles are complementary measurements to evaluate with high accuracy the degree of frontal angulation. In preoperative assessment, they may guide surgery decision in particular when the choice is not straightforward.

Published
2020

13. Investigating dynamic susceptibility contrast-enhanced perfusion-weighted magnetic resonance imaging in posterior fossa tumors: differences and similarities with supratentorial tumors

Author

Gaudino, Simona, Benenati, M., Martucci, M., Botto, Annibale, Infante, A., Marrazzo, Antonio, Ramaglia, A., Marziali, G., Guadalupi, Pamela, Colosimo, Cesare, Gaudino S. (ORCID:0000-0003-1681-4343), Botto A., Marrazzo A., Guadalupi P., Colosimo C. (ORCID:0000-0003-3800-3648), Gaudino, Simona, Benenati, M., Martucci, M., Botto, Annibale, Infante, A., Marrazzo, Antonio, Ramaglia, A., Marziali, G., Guadalupi, Pamela, Colosimo, Cesare, Gaudino S. (ORCID:0000-0003-1681-4343), Botto A., Marrazzo A., Guadalupi P., and Colosimo C. (ORCID:0000-0003-3800-3648)

Abstract

Purpose: To assess the accuracy of dynamic susceptibility contrast-enhanced perfusion-weighted magnetic resonance imaging in glioma grading and brain tumor characterization of infratentorial tumors, and to investigate differences from supratentorial tumors. Methods: This retrospective study, approved by the institutional review board, included 246 patients with brain tumors (184 supratentorial, 62 infratentorial), grouped by tumor type: high-grade gliomas (HGG), low-grade gliomas (LGG), metastases (Met), and primary central nervous system lymphoma (PCNSL). Relative cerebral blood volume (rCBV) and mean percentage of signal recovery (PSR) were calculated. For statistical analyses, lesions were grouped by location and histology. Differences were tested with Mann–Whitney U tests. From ROC curves, we calculated accuracy, sensitivity, specificity, PPV, and NPV, for rCBV and PSR. Results: For infratentorial tumors, rCBV was highly accurate in differentiating HGG from LGG (AUC = 0.938). Mean PSR showed high accuracy in differentiating PCNSL and HGG from Met (AUC = 0.978 and AUC = 0.881, respectively). Infratentorial and supratentorial tumors had similarly high rCBV in HGG, high mean PSR in PCNSL, and low mean PSR in Met. The main differences were the optimum threshold rCBV values (3.04 for supratentorial, 1.77 for infratentorial tumors) and the mean PSR, which was significantly higher in LGG than in HGG in supratentorial (p = 0.035), but not infratentorial gliomas. Using infratentorial rCBV threshold values for supratentorial tumors decreased the sensitivity and specificity. Conclusion: rCBV and mean PSR were useful in grading and differentiating infratentorial tumors. Proper cutoff values were important in the accuracy of perfusion-weighted imaging in posterior fossa tumors.

Published
2020

14. MRI features as a helpful tool to predict the molecular subgroups of medulloblastoma: state of the art

Author

Colafati, Giovanna Stefania, primary, Voicu, Ioan Paul, additional, Carducci, Chiara, additional, Miele, Evelina, additional, Carai, Andrea, additional, Di Loreto, Simona, additional, Marrazzo, Antonio, additional, Cacchione, Antonella, additional, Cecinati, Valerio, additional, Tornesello, Assunta, additional, and Mastronuzzi, Angela, additional

Published
2018
Full Text
View/download PDF

15. Laparoscopic lower lateral incisional hernia repair after kidney transplant

Author

DAMIANO, Giuseppe, PALUMBO, Vincenzo Davide, SPINELLI, Gabriele, FICARELLA, Silvia, Buscemi, Salvatore, SINAGRA, Emanuele, MARRAZZO, Antonio, LO MONTE, Attilio Ignazio, Damiano, G, Palumbo, VD, Spinelli, G, Ficarella, S, Buscemi, S, Sinagra, E, Marrazzo, A, and Lo Monte, AI

Subjects
Settore MED/18 - Chirurgia Generale, Hernia mesh, Boundary hernia, Laparoscopy, Incisional hernia
Published
2015

16. NRASQ61K mutated primary leptomeningeal melanoma in a child: case presentation and discussion on clinical and diagnostic implications

Author

Angelino, Giulia, primary, De Pasquale, Maria Debora, additional, De Sio, Luigi, additional, Serra, Annalisa, additional, Massimi, Luca, additional, De Vito, Rita, additional, Marrazzo, Antonio, additional, Lancella, Laura, additional, Carai, Andrea, additional, Antonelli, Manila, additional, Giangaspero, Felice, additional, Gessi, Marco, additional, Menchini, Laura, additional, Scarciolla, Laura, additional, Longo, Daniela, additional, and Mastronuzzi, Angela, additional

Published
2016
Full Text
View/download PDF

17. Anomalous vascularization in a Wnt medulloblastoma: a case report

Author

Di Giannatale, Angela, primary, Carai, Andrea, additional, Cacchione, Antonella, additional, Marrazzo, Antonio, additional, Dell’Anna, Vito Andrea, additional, Colafati, Giovanna Stefania, additional, Diomedi-Camassei, Francesca, additional, Miele, Evelina, additional, Po, Agnese, additional, Ferretti, Elisabetta, additional, Locatelli, Franco, additional, and Mastronuzzi, Angela, additional

Published
2016
Full Text
View/download PDF

19. NS-15NEUROSURGICAL MANAGEMENT OF TECTAL GLIOMAS

Author

Carai, Andrea, primary, Marrazzo, Antonio, additional, dell'Anna, Vito Andrea, additional, De Benedictis, Alessandro, additional, Messina, Raffaella, additional, Randi, Franco, additional, Colafati, Giovanna Stefania, additional, Cacchione, Antonella, additional, Miele, Evelina, additional, Mastronuzzi, Angela, additional, and Marras, Carlo Efisio, additional

Published
2016
Full Text
View/download PDF

20. NS-25IMPACT OF MEDULLOBLASTOMA MOLECULAR SUBGROUP ON POST-OPERATIVE PSEUDOMENINGOCELE AND NEED FOR VENTRICULAR SHUNTING

Author

Esposito, Giacomo, primary, dell'Anna, Vito Andrea, additional, Marrazzo, Antonio, additional, Carai, Andrea, additional, Messina, Raffaella, additional, De Benedictis, Alessandro, additional, Randi, Franco, additional, Cacchione, Antonella, additional, Miele, Evelina, additional, Colafati, Giovanna Stefania, additional, Tornesello, Assunta, additional, Po, Agnese, additional, Ferretti, Elisabetta, additional, Mastronuzzi, Angela, additional, Fontanella, Marco Maria, additional, and Marras, Carlo Efisio, additional

Published
2016
Full Text
View/download PDF

22. Stili difensivi, alessitimia e percezione della qualità della vita in pazienti affette da neoplasia al seno

Author

MARRAZZO, Giovanna, MARRAZZO, Antonio, LA BARBERA, Daniele, Rizzo, R, Marinaro, AM, Marrazzo, G, Rizzo, R, Marinaro, AM, Marrazzo, A, and La Barbera, D

Subjects
stili difensivi, alessitimia, qualità della vita, neoplasia al seno
Abstract

Introduzione: Il presente lavoro indaga la qualità delle reazioni emotive e psicologiche delle pazienti affette da cancro mammario, sottoposte a intervento chirurgico e in diversi stadi di malattia. Metodologia: Il campione è composto da 110 pazienti così suddivise: 40 in follow-up, 41 sottoposte a chemioterapia adiuvante, 29 metastatiche. Strumenti: Defense Mechanisms Inventory (DMI, Ihilevich e Gleser, 1986), Toronto Alexithymia Scale (TAS-20, Taylor GJ,1992), EORTC QLQ-C30-BR23 (Fayers PM et al 1998). Risultati: Nei tre gruppi si rivela differenza alle scale F1 (p

Published
2011

24. Surgical treatment of early breast cancer in day surgery

Author

MARRAZZO, Antonio, LO GERFO, Domenico, TAORMINA, P, MERCADANTE, S, DAVID, M, RIILI, I, CASA', L, NOTO, A., MARRAZZO, A, TAORMINA, P, MERCADANTE, S, DAVID, M, RIILI, I, LO GERFO, D, CASA', L, and NOTO, A

Subjects
day surgery, Adult, Aged, 80 and over, Sentinel Lymph Node Biopsy, Carcinoma, Ductal, Breast, Early breast cancer, Breast Neoplasms, Middle Aged, Mastectomy, Segmental, Carcinoma, Lobular, Treatment Outcome, Ambulatory Surgical Procedures, Patient Satisfaction, Axilla, Biomarkers, Tumor, Humans, Lymph Node Excision, Female, Neoplasm Invasiveness, Sicily, Aged, Neoplasm Staging
Abstract

Quadrantectomy and associated sentinel lymph node biopsy (SLNB) is currently employed in most breast surgery centres as the gold standard in the treatment of early breast cancer. This approach has a modest morbidity and can usually be performed in a day-surgery regimen, leading to best acceptance by the patients. This reports outlines the experience of our Breast Unit with quadrantectomy and SLNB in day surgery for early breast cancer. One hundred patients presenting to our institution with primary invasive breast cancer measuring less than 3 cm and clinically negative axillary nodes underwent quadrantectomy and SLNB in day surgery. For 60 women with breast cancer the sentinel node was negative, so the only definitive surgical treatment was performed in the day-surgery regimen; 40 patients with positive sentinel nodes were hospitalised a second time for axillary dissection. In these patients that needed clearance of the axilla, SLNB was performed on the only positive node in 22 cases (55%). None of the patients admitted for quadrantectomy and SLNB in day surgery required re-hospitalisation after discharge. All patients proved to be fully satisfied with early discharge from hospital when questioned on the occasion of subsequent monitoring. Short-stay surgical programs in early invasive breast cancer treatment are feasible today owing to the availability of less invasive approaches such as quadrantectomy and SLNB. There are two main pointers to a distinct advantage for this kind of approach, i.e. recovery and psychological adjustment. Recovery from surgery is faster and the patient tends to play down the seriousness of the operation and to have a better mental attitude to neoplastic disease. Moreover, when performing quadrantectomy with SLNB in day surgery fewer than 50% of breast cancer patients (40% in our experience) require another surgical treatment, concluding the surgery in a single session.

Published
2007

26. Granulomatous Mastitis during Chronic Antidepressant Therapy: Is It Possible a Conservative Therapeutic Approach?

Author

Bellavia, Maurizio, primary, Damiano, Giuseppe, additional, Palumbo, Vincenzo Davide, additional, Spinelli, Gabriele, additional, Tomasello, Giovanni, additional, Marrazzo, Antonio, additional, Ficarella, Silvia, additional, Bruno, Antonio, additional, Sammartano, Antonino, additional, Fiorentini, Tiziana, additional, Scio, Antonio, additional, Maione, Carolina, additional, and Lo Monte, Attilio Ignazio, additional

Published
2012
Full Text
View/download PDF

27. Myc Promoter-Binding Protein-1 (MBP-1) Is a Novel Potential Prognostic Marker in Invasive Ductal Breast Carcinoma

Author

Lo Presti, Mariavera, primary, Ferro, Arianna, additional, Contino, Flavia, additional, Mazzarella, Claudia, additional, Sbacchi, Silvia, additional, Roz, Elena, additional, Lupo, Carmelo, additional, Perconti, Giovanni, additional, Giallongo, Agata, additional, Migliorini, Paola, additional, Marrazzo, Antonio, additional, and Feo, Salvatore, additional

Published
2010
Full Text
View/download PDF

30. A Misunderstood intestinal perforation believed acute pancreatitis: A case report

Author

Vincenzo Davide Palumbo, Tomasello, Giovanni, Damiano, Giuseppe, Spinelli, Gabriele, Luca, Salvatore, Ficarella, Silvia, Maffongelli, Angela, Fazzotta, Salvatore, Buscemi, Salvatore, Marrazzo, Antonio, Maione, Carolina, Buscemi, Giuseppe, Di Carlo, Giovanni, Sammartano, Antonino, Sinagra, Emanuele, Lo Monte, Attilio Ignazio, Palumbo, VD, Tomasello, G, Damiano, G, Spinelli, G, De Luca, S, Ficarella, S, Maffongelli, A, Fazzotta, S, Buscemi, S, Marrazzo, A, Maione, C, Buscemi, G, Di Carlo, G, Sammartano, A, Sinagra, E, and Lo Monte, AI

Subjects
Settore MED/18 - Chirurgia Generale, Cholecystectomy, Intestinal perforation, Pancreatitis
Abstract

Acute pancreatitis represents one, possible but rare, of the several complications of laparoscopic cholecystectomy. In the case reported, a 31-year-old female patient complained of abdominal pain after laparoscopic cholecystectomy. The clinical picture, the high values of serum amylase, lipase and white blood cell count and the subsequent abdominal computed tomography (CT) led to diagnose an acute biliary pancreatitis. This was pharmacologically treated, but the patient worsened in a few days. A contrastenhanced CT showed the presence of free air and effusion into the peritoneal cavity. The patient was submitted to another intervention, which revealed a 1-cm jejunal perforation. The injured loop was then repaired and the patient discharged after three days. The cause remains obscure but it was likely due to umbilical trocar insertion. An upper quadrant abdominal pain with elevated amylase and lipase serum concentration, not always indicate the presence of an acute pancreatitis but could be associated to a difficult case of intestinal perforation.

31. Ileus following spontaneous jejunum intramural hematoma: case report and review of the literature

Author

Spinelli, Gabriele, Damiano, Giuseppe, Palumbo, Vincenzo Davide, Sammartano, Antonino, Maione, Carolina, Marrazzo, Antonio, Bellavia, Maurizio, Rita Barone, Buscemi, Giuseppe, Lo Monte, Attilio Ignazio, Spinelli, G, Damiano, G, Palumbo, VD, Sammartano, A, Maione, C, Marrazzo, A, Bellavia, M, Barone, R, Buscemi, G, and Lo Monte, AI

Subjects
Hematoma, Heparin, Spontaneous intramural hematoma, Anticoagulants, Jejunal Diseases, Middle Aged, Settore MED/15 - Malattie Del Sangue, Settore MED/18 - Chirurgia Generale, Ileus, Humans, Female, Anticoagulant therapy, Bowel obstruction
Abstract

Anticoagulant therapy may cause the onset of a spontaneous intramural hema- toma of the small bowel, in the jejunum, ileum or duodenum. A 53-year-old woman on therapy with heparin for previous pulmonary embolism was admitted for abdominal pain and vomit. Computed tomography scan visualized an intramural hematoma of the jejunum causing subtotal obstruction of the intestinal lumen. The patient underwent resection of a part of the jejunum, securing intestinal continuity by a mechanical side-to-side anastomosis. The postoperative course was regular, but the initial anticoagulant therapy was reduced to prevent recurrence. In conclusion, spontaneous hema- toma of small bowel can occur as a complication of anticoagulant therapy. The clinical picture and rapid diagnosis indicate medical or surgical therapy.

32. Ileus following spontaneous jejunum intramural hematoma: case report and review of the literature.

Author

Spinelli G, Damiano G, Palumbo VD, Sammartano A, Maione C, Marrazzo A, Bellavia M, Barone R, Buscemi G, and Lo Monte AI

Subjects
Anticoagulants adverse effects, Female, Hematoma chemically induced, Hematoma surgery, Heparin adverse effects, Humans, Jejunal Diseases chemically induced, Jejunal Diseases surgery, Middle Aged, Hematoma complications, Ileus etiology, Jejunal Diseases complications
Abstract

Anticoagulant therapy may cause the onset of a spontaneous intramural hematoma of the small bowel, in the jejunum, ileum or duodenum. A 53-year-old woman on therapy with heparin for previous pulmonary embolism was admitted for abdominal pain and vomit. Computed tomography scan visualized an intramural hematoma of the jejunum causing subtotal obstruction of the intestinal lumen. The patient underwent resection of a part of the jejunum, securing intestinal continuity by a mechanical side-to-side anastomosis. The postoperative course was regular, but the initial anticoagulant therapy was reduced to prevent recurrence. In conclusion, spontaneous hematoma of small bowel can occur as a complication of anticoagulant therapy. The clinical picture and rapid diagnosis indicate medical or surgical therapy.

Published
2012

33. An unexpected surprise at the end of a "quiet" cholecystectomy. A case report and review of the literature.

Author

Fazio V, Damiano G, Palumbo VD, Spinelli G, Scio A, Tomasello G, Marrazzo A, Buscemi S, and Lo Monte AI

Subjects
Humans, Male, Middle Aged, Cholecystectomy
Abstract

Background: Anatomic unexpected variations in biliary tree may be discovered during laparoscopic cholecystectomy., Case Report: A 57-year-old man was admitted for abdominal pain, vomiting and mild jaundice. Abdominal ultrasonography revealed a gallbladder containing multiple stones and biliary sludge. All pre-operative investigations showed no anatomical variations in extrahepatic biliary tree. During surgical intervention an accessory extrahepatic duct, connecting the IV segment of the liver to the fundus of gallbladder, was discovered., Conclusions: Pre-operative routine investigations for gall stones diseases may not reveal anatomic variations of biliary tree.

Published
2012

34. Vinorelbine and 5-fluorouracil bolus and/or continuous venous infusion plus levofolinic acid as second-line chemotherapy for metastatic breast cancer: an analysis of results in clinical practice of the Gruppo Oncologico Italia Meridionale (GOIM).

Author

Gebbia V, Caruso M, Borsellino N, Ajello R, Tirrito ML, Chiarenza M, Valenza R, Verderame F, Varvara F, Marrazzo A, Bajardi E, Ferrao F, Bordonaro R, and Tralongo P

Subjects
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Breast Neoplasms pathology, Female, Fluorouracil administration & dosage, Fluorouracil adverse effects, Humans, Infusions, Intravenous, Injections, Intravenous, Leucovorin administration & dosage, Leucovorin adverse effects, Middle Aged, Neoplasm Metastasis, Neoplasm Recurrence, Local pathology, Retrospective Studies, Stereoisomerism, Vinblastine administration & dosage, Vinblastine adverse effects, Vinblastine analogs & derivatives, Vinorelbine, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Breast Neoplasms drug therapy, Neoplasm Recurrence, Local drug therapy
Abstract

Background: This retrospective study evaluated the activity and toxicity profile of a regimen of vinorelbine and 5-fluorouracil with levofolinic acid, given to a large series of patients with recurrent or refractory metastatic breast cancer after first-line chemotherapy., Patients and Methods: Overall, 286 evaluable patients were included in the analysis. Two chemotherapy schedules were reviewed: a) the bolus regimen consisted of levofolinic acid 100 mg/m2 and 5-fluorouracil 375 mg/m2, both administered i.v. on days 1,2 and 3, plus vinorelbine 25 mg/m2 i.v. bolus on days 1 and 8 every 3 weeks; b) the infusional regimen of levofolinic acid 100 mg/m2 given as a 2-hour infusion, followed by 5-fluorouracil 400 mg/m2 i.v. bolus and by 5-fluorouracil 600 mg/m2 administered as 22-hour continuous venous infusion (c.v.i) for 2 days, plus vinorelbine i.v. bolus on days 1 and 8., Results: Overall, twelve patients achieved a complete response (4%; 95%CL 2%-7%) and 115 patients showed a partial response (40%, 95%CL 34%-46%), for an overall response rate of 44% (95CL 39%-50%). Sixty-one patients had stable disease (21%) and 98 patients progressive disease (34%). The tumor growth control rate was 63% (95%CL 60%-71%). Patients with soft tissue metastases as the dominant disease showed the highest response rate (56%), followed by viscera (48%) and bone (33%). The difference in response rate between patients with dominant visceral disease versus those with dominant bone disease was statistically significant (p=0.038). Patients treated with the bolus schedule achieved a 40% overall response rate with a 5% complete response rate, while those who received the infusional regimen had a 48% overall response rate with a 5% complete response rate. This difference was not statistically significant (p=0.164). The overall median duration of objective responses was 8.3 months (range 4-14 months), median time to progression of the all series was 6.1 months (range 2-24 months) and the median overall survival was 14.6 months (range 3-32). There was a statistically significant difference in survival among responder and non-responder patients (p=0.0009)., Conclusion: The results of this large off-trial analysis confirmed the clinical activity and adverse-event profile reported in controlled clinical trials of the vinorelbine/ 5-fluorouracil with levofolinic acid regimen in clinical practice. This combination regimen was active with a low toxicity burden and, therefore, represents a good therapeutic choice for patients who require second-line chemotherapy.

Published
2006

Catalog

Books, media, physical & digital resources
See catalog results