43 results on '"Mariotti, Cesare"'
Search Results
2. Novel Artificial Intelligence-Based Assessment of Imaging Biomarkers in Full-Thickness Macular Holes: Preliminary Data from a Pivotal Trial
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Mariotti, Cesare, primary, Mangoni, Lorenzo, additional, Iorio, Silvia, additional, Lombardo, Veronica, additional, Fruttini, Daniela, additional, Rizzo, Clara, additional, Chhablani, Jay, additional, Midena, Edoardo, additional, and Lupidi, Marco, additional
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- 2024
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3. Role of Vitreous Detachment in Epiretinal Membrane Peeling: A Multimodal Imaging and Microperimetry Study.
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Serino, Federica, Franco, Fabrizio Gaetano Saverio, Bacherini, Daniela, Lupidi, Marco, Gallio, Stefano, Esposito, Claudio, Virgili, Gianni, Mariotti, Cesare, and Giansanti, Fabrizio
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CHEMICAL peel ,PARS plana ,PERIMETRY ,DIAGNOSTIC imaging ,VISUAL acuity ,COHERENCE (Optics) ,VITRECTOMY - Abstract
Background: To investigate anatomical and functional changes of the macula caused by epiretinal membrane (ERM) peeling procedures in patients with or without posterior vitreous detachment (PVD). Methods: This is a multicentric prospective observational study on thirty-seven (37) patients affected by symptomatic ERM who underwent 25-gauge pars plana vitrectomy (PPV), induction of a PVD (as needed) and peeling of both the internal limiting membrane (ILM) and ERM. Optical coherence tomography–angiography (OCT-A) (RS 3000, Nidek, Japan) and microperimetry (MP-3, Nidek, Japan) were performed; central retinal thickness (CRT), foveal avascular zone (FAZ) area and perimeter, vessel density and perfusion density, retinal sensitivity and fixation stability (as a total mean retinal sensitivity (MRS), and MRS in the ellipse area and bivariate contour ellipse area (BCEA)) were recorded at baseline and up to postoperative month 3. Results: Eyes were classified as having complete PVD (51.4%) or incomplete PVD (48.6%). At baseline, patients with incomplete PVD had worse best-corrected distance visual acuity (BCDVA), total MRS, MRS in the ellipse area and BCEA, and higher CRT than patients with complete PVD. At month 3, the differences in BCDVA between the two groups remained statistically significant, with patients with incomplete PVD having worse results (difference: 0.199 logMAR, p < 0.001). The difference in the MRS in the ellipse area was statistically significant at month 3 (−3.378 Db, p = 0.035), with greater improvement in patients with complete PVD. Conclusions: Our study shows that patients with incomplete PVD have worse conditions at baseline than patients with complete PVD, and the differences in visual acuity and retinal sensitivity were maintained postoperatively. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Quantitative and Qualitative Assessments of Retinal Structure with Variable A-Scan Rate Spectralis OCT: Insights into IPL Multilaminarity
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Lupidi, Marco, primary, Mangoni, Lorenzo, additional, Centini, Chiara, additional, Pompucci, Gregorio, additional, Lanzafame, Luca, additional, Danieli, Luca, additional, Fruttini, Daniela, additional, Peiretti, Enrico, additional, Chhablani, Jay, additional, and Mariotti, Cesare, additional
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- 2023
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5. Validation of an Automated Artificial Intelligence Algorithm for the Quantification of Major OCT Parameters in Diabetic Macular Edema
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Midena, Edoardo, primary, Toto, Lisa, additional, Frizziero, Luisa, additional, Covello, Giuseppe, additional, Torresin, Tommaso, additional, Midena, Giulia, additional, Danieli, Luca, additional, Pilotto, Elisabetta, additional, Figus, Michele, additional, Mariotti, Cesare, additional, and Lupidi, Marco, additional
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- 2023
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6. Quantification of Carbonic Anhydrase Inhibitors and Metabolites in Urine and Hair of Patients and Their Relatives
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Lo Faro, Alfredo Fabrizio, primary, Tini, Anastasio, additional, Bambagiotti, Giulia, additional, Pirani, Filippo, additional, Faragalli, Andrea, additional, Carle, Flavia, additional, Pacella, Elena, additional, Ceka, Artan, additional, Moretti, Marco, additional, Gottardi, Massimo, additional, Lassandro, Nicola Vito, additional, Nicolai, Michele, additional, Lupidi, Marco, additional, Mariotti, Cesare, additional, Busardò, Francesco Paolo, additional, and Carlier, Jeremy, additional
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- 2022
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7. Early Structural and Vascular Changes after Within-24 Hours Vitrectomy for Recent Onset Rhegmatogenous Retinal Detachment Treatment: A Pilot Study Comparing Bisected Macula and Not Bisected Macula
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D’Aloisio, Rossella, primary, Gironi, Matteo, additional, Verdina, Tommaso, additional, Vivarelli, Chiara, additional, Leonelli, Riccardo, additional, Mariotti, Cesare, additional, Kaleci, Shaniko, additional, Toto, Lisa, additional, and Mastropasqua, Rodolfo, additional
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- 2022
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8. In-vivo visualization of the photoreceptors using Spectralis High Magnification Module imaging in central serous chorioretinopathy
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Gujar, Ramkailash, primary, Muzi, Alessio, additional, Cagini, Carlo, additional, Mariotti, Cesare, additional, Piccolino, Felice Cardillo, additional, Chhablani, Jay, additional, and Lupidi, Marco, additional
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- 2022
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9. Early Structural and Vascular Changes after Within-24 Hours Vitrectomy for Recent Onset Rhegmatogenous Retinal Detachment Treatment: A Pilot Study Comparing Bisected Macula and Not Bisected Macula.
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D'Aloisio, Rossella, Gironi, Matteo, Verdina, Tommaso, Vivarelli, Chiara, Leonelli, Riccardo, Mariotti, Cesare, Kaleci, Shaniko, Toto, Lisa, and Mastropasqua, Rodolfo
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RETINAL surgery ,RETINAL detachment ,OPTICAL coherence tomography ,VITRECTOMY ,PILOT projects - Abstract
Background: In this study we aimed at investigating macular perfusion/anatomical changes in eyes with early onset rhegmatogenous retinal detachment (RRD) after prompt surgery within 24 hours, comparing a bisected macula and not bisected macula RRD. Methods: In this prospective observational study, 14 eyes of 14 patients who underwent within-24 hours vitreoretinal surgery for early onset RRD were enrolled. Patients were further divided into two subgroups: the not bisected macula group (NBM group) and the bisected macula group (BM group). At baseline and 3-month follow up, macular architecture and vessel analysis were assessed using optical coherence tomography angiography (OCTA) imaging. In detail, quantitative and qualitative analyses of the macular area were performed to quantify topographical retinal perfusion changes after surgery, calculating the foveal avascular zone (FAZ), vessel density (VD) and vessel length density (VLD) at the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Results: Most cases (43%) were superotemporal RRD. Primary retinal reattachment was obtained in all cases, without recurrences within 3-month follow up. After surgery, a significant FAZ enlargement was observed at both the SCP and DCP level (p < 0.001; p < 0.05), with a significant effect of time noted between the two time points in the NBM and BM subanalysis (F = 3.68; p < 0.017). An excellent functional outcome was maintained for the whole follow-up. On the other hand, after surgery, perfusion parameters did not change significantly apart from the vessel density of the inferior macular sector at the DCP level (p = 0.03). Conclusions: Our findings suggest that the macular perfusion of eyes with RRD is still preserved if the surgery is performed really promptly, thus highlighting the great importance of a correct timing for surgery. OCTA analysis allows for a better understanding of the pathophysiological mechanisms underneath early vascular microarchitecture modifications of the posterior pole in retinal detachment, differentiating the two types of RRD not completely involving the fovea (BM and NBM). [ABSTRACT FROM AUTHOR]
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- 2022
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10. EX-PRESS Glaucoma Filtration Device: Management of Complications
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Nicolai, Michele, primary, Franceschi, Alessandro, additional, Pelliccioni, Paolo, additional, Pirani, Vittorio, additional, and Mariotti, Cesare, additional
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- 2020
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11. Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review
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Nicolai, Michele, primary, Lassandro, Nicola, additional, Franceschi, Alessandro, additional, Rosati, Alessandro, additional, De Turris, Serena, additional, Pelliccioni, Paolo, additional, Pirani, Vittorio, additional, and Mariotti, Cesare, additional
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- 2020
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12. Intraocular Inflammation Control and Changes in Retinal and Choroidal Architecture in Refractory Non-Infectious Uveitis Patients after Adalimumab Therapy
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Pirani, Vittorio, primary, Pelliccioni, Paolo, additional, De Turris, Serena, additional, Rosati, Alessandro, additional, Franceschi, Alessandro, additional, Pasanisi, Pierangelo, additional, Gesuita, Rosaria, additional, Nicolai, Michele, additional, and Mariotti, Cesare, additional
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- 2020
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13. Early Retinal Flow Changes after Vitreoretinal Surgery in Idiopathic Epiretinal Membrane Using Swept Source Optical Coherence Tomography Angiography
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Mastropasqua, Rodolfo, primary, D’Aloisio, Rossella, additional, Viggiano, Pasquale, additional, Borrelli, Enrico, additional, Iafigliola, Carla, additional, Di Nicola, Marta, additional, Aharrh-Gnama, Agbéanda, additional, Di Marzio, Guido, additional, Toto, Lisa, additional, Mariotti, Cesare, additional, and Carpineto, Paolo, additional
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- 2019
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14. Intraocular Biopsy and ImmunoMolecular Pathology for “Unmasking” Intraocular Inflammatory Diseases
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Mastropasqua, Rodolfo, primary, Di Carlo, Emma, additional, Sorrentino, Carlo, additional, Mariotti, Cesare, additional, and da Cruz, Lyndon, additional
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- 2019
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15. Anatomical and Functional Changes of the Retina and the Choroid after Resolved Chronic CSCR
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Toto, Lisa, primary, D’Aloisio, Rossella, additional, Mastropasqua, Rodolfo, additional, Di Antonio, Luca, additional, Di Nicola, Marta, additional, Di Martino, Giuseppe, additional, Evangelista, Federica, additional, Erroi, Emanuele, additional, Doronzo, Emanuele, additional, and Mariotti, Cesare, additional
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- 2019
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16. Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cells
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Lazzarini, Raffaella, primary, Nicolai, Michele, additional, Pirani, Vittorio, additional, Mariotti, Cesare, additional, and Di Primio, Roberto, additional
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- 2018
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17. Juxtapapillary Retinal Capillary Hemangioma: New Therapeutic Strategies
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Saitta, Andrea, Nicolai, Michele, Giovannini, Alfonso, and Mariotti, Cesare
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Therapeutic Strategies ,Juxtapapillary Retinal Capillary Hemangioma ,Papillomacular Bundle ,sense organs ,Review Article ,eye diseases - Abstract
The treatment of juxtapapillary retinal capillary hemangiomas (JRCHs) is still a therapeutic dilemma without established guidelines. Because of the location of these hemangiomas on or adjacent to the optic nerve, treatment is difficult and complex, especially when JRCHs are located in the papillomacular bundle. This manuscript reviews the clinically relevant data on literature regarding the treatment of JRCHs, focusing on novel combined therapies that have shown promising results in these lesions.
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- 2014
18. In Vivo Confocal Imaging of the Conjunctiva as a Predictive Tool for the Glaucoma Filtration Surgery Outcome
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Mastropasqua, Rodolfo, primary, Fasanella, Vincenzo, additional, Brescia, Lorenza, additional, Oddone, Francesco, additional, Mariotti, Cesare, additional, Di Staso, Silvio, additional, and Agnifili, Luca, additional
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- 2017
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19. The Conjunctiva-Associated Lymphoid Tissue in Chronic Ocular Surface Diseases
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Mastropasqua, Rodolfo, primary, Agnifili, Luca, additional, Fasanella, Vincenzo, additional, Nubile, Mario, additional, Gnama, Agbeanda A., additional, Falconio, Gennaro, additional, Perri, Paolo, additional, Di Staso, Silvio, additional, and Mariotti, Cesare, additional
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- 2017
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20. Correction: miRNAs in the vitreous humor of patients affected by idiopathic epiretinal membrane and macular hole
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Russo, Andrea, primary, Ragusa, Marco, additional, Barbagallo, Cristina, additional, Longo, Antonio, additional, Avitabile, Teresio, additional, Uva, Maurizio G., additional, Bonfiglio, Vincenza, additional, Toro, Mario D., additional, Caltabiano, Rosario, additional, Mariotti, Cesare, additional, Boscia, Francesco, additional, Romano, Mario R., additional, Di Pietro, Cinzia, additional, Barbagallo, Davide, additional, Purrello, Michele, additional, and Reibaldi, Michele, additional
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- 2017
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21. miRNAs in the vitreous humor of patients affected by idiopathic epiretinal membrane and macular hole
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Russo, Andrea, primary, Ragusa, Marco, additional, Barbagallo, Cristina, additional, Longo, Antonio, additional, Avitabile, Teresio, additional, Uva, Maurizio G., additional, Bonfiglio, Vincenza, additional, Toro, Mario D., additional, Caltabiano, Rosario, additional, Mariotti, Cesare, additional, Boscia, Francesco, additional, Romano, Mario, additional, Di Pietro, Cinzia, additional, Barbagallo, Davide, additional, Purrello, Michele, additional, and Reibaldi, Michele, additional
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- 2017
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22. Optical Coherence Tomography Angiography Findings in Stargardt Disease
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Mastropasqua, Rodolfo, primary, Toto, Lisa, additional, Borrelli, Enrico, additional, Di Antonio, Luca, additional, Mattei, Peter A., additional, Senatore, Alfonso, additional, Di Nicola, Marta, additional, and Mariotti, Cesare, additional
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- 2017
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23. A Case of Goldenhar Syndrome Associated with a New Retinal Presentation: Exudative Vitelliform Maculopathy
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Bruè, Claudia, Mariotti, Cesare, Celani, Silvia, Rossiello, Ilaria, and Giovannini, Alfonso
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genetic structures ,Article Subject ,sense organs ,eye diseases - Abstract
Goldenhar syndrome is a rare clinical disturbance with a wide range of clinical manifestations. We report on a 6-year-old male with peculiar retinal presentation of Goldenhar syndrome. The patient was referred to Ophthalmology for central scotoma in the left eye, where visual acuity was 20/100. Fundus examination was unremarkable, except for yellowish material in the central macula. SD-OCT revealed interruption of the external limiting membrane and inner and outer segment junctions, with disorganized material in the vitelliform space and subretinal fluid. Six months later, fundus and SD-OCT examinations were unchanged without treatment, but visual acuity in the left eye had improved to 20/50. Five years later, he had similar clinical manifestations in the right eye. He was started on systemic steroids. After 15 days, his visual acuity improved to 20/20 and subretinal fluid and yellowish material in the vitelliform space disappeared. Goldenhar syndrome has variable presentation, including vitelliform maculopathy.
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- 2015
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24. Vitreous Substitutes: The Present and the Future
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Donati, Simone, Caprani, Simona Maria, Airaghi, Giulia, Vinciguerra, Riccardo, Bartalena, Luigi, Testa, Francesco, Mariotti, Cesare, Porta, Giovanni, Simonelli, Francesca, and Azzolini, Claudio
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genetic structures ,Article Subject ,sense organs ,eye diseases - Abstract
Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. Finally, we describe the current studies on vitreous regeneration and cell cultures to create new intraocular gels with optimal biocompatibility and rheological properties.
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- 2014
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25. Demyelinizing Neurological Disease after Treatment with Tumor Necrosis Factor-α Antagonists
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Bruè, Claudia, primary, Mariotti, Cesare, additional, Rossiello, Ilaria, additional, Saitta, Andrea, additional, and Giovannini, Alfonso, additional
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- 2016
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26. Solar Retinopathy: A Multimodal Analysis
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Bruè, Claudia, Mariotti, Cesare, De Franco, Edoardo, Fisher, Yale, Guidotti, Jacopo Maria, and Giovannini, Alfonso
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genetic structures ,Article Subject ,sense organs ,eye diseases - Abstract
Purpose. Solar retinopathy is a rare clinical disturbance, for which spectral-domain optical coherence tomography (SD-OCT) findings are not always consistent. We report on two cases of solar retinopathy and discuss its differential diagnosis. Methods. This is an observational case study. Results. A 12-year-old female was referred to ophthalmology for bilateral scotoma. Visual acuity was 20/50 in both eyes. Fundus examination was unremarkable, except for slight yellowish material in the central macula, bilaterally. SD-OCT revealed juxtafoveal microcystic cavities in the outer retina, interruption of the external limiting membrane and the inner and outer segment junctions, with disorganized material in the vitelliform space. Fundus autofluorescence showed hypoautofluorescence surrounded by a relatively hyperautofluorescent ring, bilaterally. Similar clinical and morphological findings were detected in a 27-year-old male. Conclusions. Solar retinopathy has a subtle presentation and patients often deny sun-gazing. SD-OCT and fundus autofluorescence are noninvasive and useful tools for its diagnosis.
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- 2013
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27. Pigmented Free-Floating Posterior Vitreous Cyst
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Bruè, Claudia, Mariotti, Cesare, De Franco, Edoardo, De Franco, Nicola, and Giovannini, Alfonso
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genetic structures ,Article Subject ,sense organs ,eye diseases - Abstract
Vitreous cysts are very rare ocular malformations. In this observational case study, we report on an unusual case of a pigmented free-floating vitreous cyst and discuss its differential diagnosis. A 14-year-old male was referred to ophthalmology for a pigmented lesion in his left eye. He complained of an intermittent floater in the left eye. Visual acuity was 20/20 in the right eye and 20/40 in the left eye. Fundus examination was unremarkable bilaterally, except for a piece of brownish oval material floating in the vitreous in the left eye. He had received a knock on the left side of his head a few days before the visual discomfort of the left eye. Real-time ultrasound of the left eye detected a piece of hyperechogenic spherical material with no internal reflectivity, floating in the middle of the vitreous. The first use of color Doppler ultrasound in this context indicated no arterial flow, ruling out the presence of a persistent hyaloid artery. Intraocular cysts are rare ocular disorders, which have been divided into clear and pigmented cysts, and into those that occupy the anterior chamber, the retrolental space, and the vitreous cavity. This last is extremely rare. We describe such a case.
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- 2012
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28. Cost-effectiveness of intravitreal therapy in Age-Related Macular Degeneration
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Neri, Piergiorgio, primary, Arapi, Ilir, additional, Eandi, Chiara Maria, additional, Pirani, Vittorio, additional, Mariotti, Cesare, additional, and Giovannini, Alfonso, additional
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- 2014
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29. Atypical Presentation of Antiphospholipid Syndrome: A Case Report
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Mariotti, Cesare, primary, Giovannini, Alfonso, additional, Reibaldi, Michele, additional, Saitta, Andrea, additional, Viti, Francesca, additional, and Nicolai, Michele, additional
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- 2014
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30. 25-Gauge Vitrectomy Combined with Half-Fluence Photodynamic Therapy for the Treatment of Juxtapapillary Retinal Capillary Hemangioma: A Case Report
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Mariotti, Cesare, primary, Giovannini, Alfonso, additional, Reibaldi, Michele, additional, Nicolai, Michele, additional, and Saitta, Andrea, additional
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- 2014
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31. Functional MRI Examination of Visual Pathways in Patients with Unilateral Optic Neuritis
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Mascioli, Giulia, primary, Salvolini, Simone, additional, Cavola, Gian Luca, additional, Fabri, Mara, additional, Giovannini, Alfonso, additional, Mariotti, Cesare, additional, Salvolini, Luca, additional, and Polonara, Gabriele, additional
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- 2012
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32. Epiretinal membrane surgery for combined hamartoma of the retina and retinal pigment epithelium: role of multimodal analysis.
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Bruè, Claudia, Saitta, Andrea, Nicolai, Michele, Mariotti, Cesare, and Giovannini, Alfonso
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RETINAL surgery ,HAMARTOMA ,PIGMENT epithelium-derived factor ,COMBINED modality therapy ,MODAL analysis ,OPTICAL coherence tomography ,RETROSPECTIVE studies - Abstract
Background: The purpose of this study was to evaluate the role of spectral domain optical coherence tomography (SD-OCT), MP-1 microperimetry, and fundus autofluorescence imaging for planning surgical procedures in combined hamartomas of the retina and retinal pigment epithelium (CHR-RPE) and following epiretinal membrane removal. Methods: In an interventional retrospective case series, six consecutive subjects with CHR-RPE underwent vitrectomy and epiretinal membrane peeling, with 4 years of follow-up. Each underwent complete ophthalmic examination, including best corrected visual acuity, fundus examination, fundus fluorescein angiography, SD-OCT, MP-1, and fundus autofluorescence at one, 6, 12, and 48 months. Results: Six eyes from six subjects with CHR-RPE were studied (mean age 31 ± 14 years). All patients were phakic and five were male (83.3%). Lesions were unilateral, ie, three macular, two juxtapapillary and macular, and one pericentral. Preoperative best corrected visual acuity was 0.3 ± 0.08 Snellen, with significant improvement to 0.9 ± 0.17 Snellen (P = 0.001) at 4 years of follow-up. Mean retinal sensitivity within the central 20° field improved from 16.6 ± 1.84 dB to 18.8 ± 0.96 dB (P = 0.07). There was also a statistically significant reduction in the visual defect (P = 0.04). SD-OCT demonstrated that the epiretinal membranes were completely removed in all but one patient, with significantly decreased macular edema on follow-up at one, 6, 12, and 48 months (P = 0.001). A positive correlation was shown between preoperative macular sensitivity and postoperative best corrected visual acuity. Fundus autofluorescence demonstrated a block in background autofluorescence at the site of the lesion, and hyperautofluorescence at the edematous retina overlain by the epiretinal membrane. Conclusion: Surgery is an effective treatment for CHR-RPE. SD-OCT, fundus autofluorescence, and MP-1 are valuable and noninvasive tools to guide surgical procedures for CHR-RPE. To the best of our knowledge, this study represents the first use of MP-1 in CHR-RPE in conjunction with SD-OCT and fundus autofluorescence imaging for better guided surgery as well as anatomical and functional prognosis. [ABSTRACT FROM AUTHOR]
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- 2013
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33. Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study.
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Nicolai, Michele, Franceschi, Alessandro, De Turris, Serena, Rosati, Alessandro, Pirani, Vittorio, and Mariotti, Cesare
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RETINAL vein occlusion ,ENDOTHELIAL growth factors ,OPTICAL coherence tomography ,INJECTIONS - Abstract
Purpose: To investigate papillary microvascular changes in patients affected by macular edema due to Central Retinal Vein Occlusions (CRVO) after anti-Vascular Endothelial Growth Factor (VEGF) therapy. Methods: Prospective analysis of papillary and peripapillary vessel density (VD) changes in 18 eyes of 18 hypertensive patients affected by CRVO before and after the loading-phase of intravitreal Ranibizumab (IVR) injections. Data were quantitatively measured by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) before as well as 1 month and 4 months after injections. The correlation between post-treatment best-corrected visual acuity (BCVA) and changes in the retinal microvasculature evaluated by OCTA was assessed. Results: 18 eyes of 18 consecutive patients with a known history of arterial hypertension and affected by an acute CRVO episode were enrolled. Central macular thickness (CMT) was significantly reduced after IVR injections (p < 0.001), while mean BCVA improved from 0.70 ± 0.26 logarithm of the minimal angle of resolution (logMAR) units at baseline to 0.25 ± 0.18 logMAR units after 4 months (p < 0.001). VD inside disc and peripapillary significantly increased (p < 0.001 and p = 0.01, respectively) after treatment. Conclusions: OCTA showed VD increase in the papillary area in patients affected by CRVO after anti-VEGF therapy. This area could represent a new region of interest to study microvasculature changes concomitant with severe macular edema. [ABSTRACT FROM AUTHOR]
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- 2019
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34. The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging.
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Pirani, Vittorio, Pelliccioni, Paolo, De Turris, Serena, Rosati, Alessandro, Franceschi, Alessandro, Cesari, Claudia, Nicolai, Michele, and Mariotti, Cesare
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COMMUNICABLE diseases ,DIAGNOSIS ,OPTIC disc ,PHYSICIANS ,OPTICAL coherence tomography - Abstract
Background: Syphilis, tuberculosis and toxoplasmosis are major infectious diseases worldwide; all of them are multisystem pathologies and share a possible ocular involvement. In this context, a fundamental help for the definitive diagnosis is provided by the ophthalmologist, through clinical evaluation and with the aid of a multimodal imaging examination. Methods: We hereby describe selected cases who came to our attention and were visited in our eye clinic. In all clinics, the use of retinal and optic disc multimodal imaging during ophthalmological evaluation allowed to make a diagnosis of an infectious disease. Results: In our tertiary referral center more than 60 patients with syphilis, tuberculosis and toxoplasmosis have been evaluated in the last two years: In 60% of cases the ophthalmological evaluation was secondary to a previous diagnosis of an infectious disease, while in the remaining cases the ophthalmologist, with the help of a multimodal imaging examination and clinical evaluation, represented the physician who leads to the diagnosis. Conclusion: Our results confirm how in these life-threatening pathologies a prompt diagnosis is mandatory and may benefit from a multidisciplinary and multimodal imaging approach, especially during ophthalmological evaluation. [ABSTRACT FROM AUTHOR]
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- 2019
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35. Effect of COVID-19-related lockdown on ophthalmic practice in Italy: A report from 39 institutional centers
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Roberto dell’Omo, Mariaelena Filippelli, Gianni Virgili, Francesco Bandello, Giuseppe Querques, Paolo Lanzetta, Teresio Avitabile, Francesco Viola, Michele Reibaldi, Francesco Semeraro, Luciano Quaranta, Stanislao Rizzo, Edoardo Midena, Giuseppe Campagna, Ciro Costagliola, Paola Marolo, Carlo Enrico Traverso, Michele Iester, Carlo Alberto Cutolo, Claudio Azzolini, Simone Donati, Elias Premi, Paolo Nucci, Stela Vujosevic, Giovanni Staurenghi, Ferdinando Bottoni, Francesco Romano, Domenico Grosso, Enrico Borrelli, Riccardo Sacconi, Paolo Milella, Simone Ganci, Mario R. Romano, Gabriella Ricciardelli, Davide Allegrini, Marco Casaluci, Davide Romano, Giorgio Marchini, Francesca Chemello, Camilla Amantea, Rino Frisina, Elisabetta Pilotto, Raffaele Parrozzani, Daniele Veritti, Valentina Sarao, Tognetto Daniele, Massimo Busin, Francesco Parmeggiani, Katia De Nadai, Luca Furiosi, Rodolfo Mastropasqua, Bruno Battaglia, Matteo Gironi, Stefano Gandolfi, Enrico Luciani, Paolo Mora, Costantino Schiavi, Patrizia Bertaccini, Alessandro Finzi, Matilde Roda, Carlo Cagini, Marco Lupidi, Fabrizio Giansanti, Daniela Bacherini, Gianmarco Tosi, Elena De Benedetto, Marco Nardi, Michele Figus, Chiara Posarelli, Cesare Mariotti, Vittorio Pirani, Michele Nicolai, Stefano Bonini, Marco Coassin, Antonio Di Zazzo, Mariacristina Savastano, Alfonso Savastano, Gloria Gambini, Umberto De Vico, Leopoldo Spadea, Andrea Iannaccone, Carlo Nucci, Federico Ricci, Francesco Aiello, Gabriele Gallo Afflitto, Leonardo Mastropasqua, Giada D’Onofio, Federica Evangelista, Lorenza Brescia, Pasquale Napolitano, Paolo Polisena, Nicolina Gianfrancesco, Domenico Trivisonno, Francesco Petti, Francesca Simonelli, Settimio Rossi, Antonio Tartaglione, Nicola Rosa, Maddalena De Bernardo, Cristiana Iaculli, Anna Valeria Bux, Giulia Maggiore, Francesco Boscia, Giancarlo Sborgia, Maria Oliva Grassi, Vincenzo Scorcia, Giuseppe Giannaccare, Guglielmo Parisi, Salvatore Cillino, Francesco Alaimo, Pasquale Aragona, Alessandro Meduri, Antonio Pinna, Andrea Sollazzo, Enrico Peiretti, Emanuele Siotto, dell’Omo, Roberto, Filippelli, Mariaelena, Virgili, Gianni, Bandello, Francesco, Querques, Giuseppe, Lanzetta, Paolo, Avitabile, Teresio, Viola, Francesco, Reibaldi, Michele, Semeraro, Francesco, Quaranta, Luciano, Rizzo, Stanislao, Midena, Edoardo, Campagna, Giuseppe, Costagliola, Ciro, Marolo, Paola, Traverso, Carlo Enrico, Iester, Michele, Cutolo, Carlo Alberto, Azzolini, Claudio, Donati, Simone, Premi, Elia, Nucci, Paolo, Vujosevic, Stela, Staurenghi, Giovanni, Bottoni, Ferdinando, Romano, Francesco, Grosso, Domenico, Borrelli, Enrico, Sacconi, Riccardo, Milella, Paolo, Ganci, Simone, Romano, Mario R., Ricciardelli, Gabriella, Allegrini, Davide, Casaluci, Marco, Romano, Davide, Marchini, Giorgio, Chemello, Francesca, Amantea, Camilla, Frisina, Rino, Pilotto, Elisabetta, Parrozzani, Raffaele, Veritti, Daniele, Sarao, Valentina, Daniele, Tognetto, Busin, Massimo, Parmeggiani, Francesco, De Nadai, Katia, Furiosi, Luca, Mastropasqua, Rodolfo, Battaglia, Bruno, Gironi, Matteo, Gandolfi, Stefano, Luciani, Enrico, Mora, Paolo, Schiavi, Costantino, Bertaccini, Patrizia, Finzi, Alessandro, Roda, Matilde, Cagini, Carlo, Lupidi, Marco, Giansanti, Fabrizio, Bacherini, Daniela, Tosi, Gianmarco, De Benedetto, Elena, Nardi, Marco, Figus, Michele, Posarelli, Chiara, Mariotti, Cesare, Pirani, Vittorio, Nicolai, Michele, Bonini, Stefano, Coassin, Marco, Di Zazzo, Antonio, Savastano, Mariacristina, Savastano, Alfonso, Gambini, Gloria, Vico, Umberto De, Spadea, Leopoldo, Iannaccone, Andrea, Nucci, Carlo, Ricci, Federico, Aiello, Francesco, Afflitto, Gabriele Gallo, Mastropasqua, Leonardo, D’Onofio, Giada, Evangelista, Federica, Brescia, Lorenza, Napolitano, Pasquale, Polisena, Paolo, Gianfrancesco, Nicolina, Trivisonno, Domenico, Petti, Francesco, Simonelli, Francesca, Rossi, Settimio, Tartaglione, Antonio, Rosa, Nicola, Bernardo, Maddalena De, Iaculli, Cristiana, Valeria Bux, Anna, Maggiore, Giulia, Boscia, Francesco, Sborgia, Giancarlo, Grassi, Maria Oliva, Scorcia, Vincenzo, Giannaccare, Giuseppe, Parisi, Guglielmo, Cillino, Salvatore, Alaimo, Francesco, Aragona, Pasquale, Meduri, Alessandro, Pinna, Antonio, Sollazzo, Andrea, Peiretti, Enrico, Siotto, Emanuele, Dell'Omo, R., Filippelli, M., Virgili, G., Bandello, F., Querques, G., Lanzetta, P., Avitabile, T., Viola, F., Reibaldi, M., Semeraro, F., Quaranta, L., Rizzo, S., Midena, E., Campagna, G., Costagliola, C., Marolo, P., Traverso, C. E., Iester, M., Cutolo, C. A., Azzolini, C., Donati, S., Premi, E., Nucci, P., Vujosevic, S., Staurenghi, G., Bottoni, F., Romano, F., Grosso, D., Borrelli, E., Sacconi, R., Milella, P., Ganci, S., Romano, M. R., Ricciardelli, G., Allegrini, D., Casaluci, M., Romano, D., Marchini, G., Chemello, F., Amantea, C., Frisina, R., Pilotto, E., Parrozzani, R., Veritti, D., Sarao, V., Daniele, T., Busin, M., Parmeggiani, F., De Nadai, K., Furiosi, L., Mastropasqua, R., Battaglia, B., Gironi, M., Gandolfi, S., Luciani, E., Mora, P., Schiavi, C., Bertaccini, P., Finzi, A., Roda, M., Cagini, C., Lupidi, M., Giansanti, F., Bacherini, D., Tosi, G., De Benedetto, E., Nardi, M., Figus, M., Posarelli, C., Mariotti, C., Pirani, V., Nicolai, M., Bonini, S., Coassin, M., Di Zazzo, A., Savastano, M., Savastano, A., Gambini, G., Vico, U. D., Spadea, L., Iannaccone, A., Nucci, C., Ricci, F., Aiello, F., Afflitto, G. G., Mastropasqua, L., D'Onofio, G., Evangelista, F., Brescia, L., Napolitano, P., Polisena, P., Gianfrancesco, N., Trivisonno, D., Petti, F., Simonelli, F., Rossi, S., Tartaglione, A., Rosa, N., Bernardo, M. D., Iaculli, C., Valeria Bux, A., Maggiore, G., Boscia, F., Sborgia, G., Grassi, M. O., Scorcia, V., Giannaccare, G., Parisi, G., Cillino, S., Alaimo, F., Aragona, P., Meduri, A., Pinna, A., Sollazzo, A., Peiretti, E., and Siotto, E.
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medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,medicine.medical_treatment ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Trauma, phacoemulsification, glaucoma, retinal detachment, choroidal neovascular membranes, venous occlusive disease, corneal transplantation ,Trauma ,choroidal neovascular membranes ,retinal detachment ,Retrospective Studie ,Settore MED/30 ,medicine ,Retrospective analysis ,choroidal neovascular membrane ,Humans ,venous occlusive disease ,Retrospective Studies ,corneal transplantation ,glaucoma ,phacoemulsification ,Communicable Disease Control ,SARS-CoV-2 ,COVID-19 ,Retinal Detachment ,Settore MED/30 - Malattie Apparato Visivo ,business.industry ,Retinal detachment ,General Medicine ,Phacoemulsification ,Surgical procedures ,medicine.disease ,Surgery ,Ophthalmology ,business ,trauma ,Human - Abstract
Background/objectives: To compare the number of eye surgical procedures performed in Italy in the 2 months following the beginning of lockdown (study period) because of COVID-19 epidemic with those performed in the two earlier months of the same year (intra-year control) and in the period of 2019 corresponding to the lockdown (inter-year control). Methods: Retrospective analysis of surgical procedures carried out at 39 Academic hospitals. A distinction was made between elective and urgent procedures. Intravitreal injections were also considered. Percentages for all surgical procedures and incidence rate ratios (IRR) for rhegmatogenous retinal detachment (RRD) events were calculated. A p value Results: A total of 20,886 versus 55,259 and 56,640 patients underwent surgery during the lockdown versus intra-and inter-year control periods, respectively. During the lockdown, only 70% of patients for whom an operation/intravitreal injection was recommended, finally underwent surgery; the remaining patients did not attend because afraid of getting infected at the hospital (23%), taking public transportation (6.5%), or unavailable swabs (0.5%). Elective surgeries were reduced by 96.2% and 96.4%, urgent surgeries by 49.7% and 50.2%, and intravitreal injections by 48.5% and 48.6% in the lockdown period in comparison to intra-year and inter-year control periods, respectively. IRRs for RRDs during lockdown dropped significantly in comparison with intra- and inter-year control periods (CI: 0.65–0.80 and 0.61–0.75, respectively, p Conclusion: This study provides a quantitative analysis of the reduction of eye surgical procedures performed in Italy because of the COVID-19 epidemic.
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- 2022
36. One week of levofloxacin plus dexamethasone eye drops for cataract surgery: an innovative and rational therapeutic strategy
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Bandello, Francesco, Coassin, Marco, Di Zazzo, Antonio, Rizzo, Stanislao, Biagini, Ilaria, Pozdeyeva, Nadezhda, Sinitsyn, Maksim, Verzin, Alexander, De Rosa, Pasquale, Calabrò, Francesco, Avitabile, Teresio, Bonfiglio, Vincenza, Fasce, Francesco, Barraquer, Rafael, Mateu, Josè Lamarca, Kohnen, Thomas, Carnovali, Marino, Malyugin, Boris, Pasquale, Aragona, Paolo, Arvedi, Carlo, Cagini, Luigi, Caretti, Gian Maria Cavallini, Salvatore, Cillino, Innocente, Figini, Livio Marco Franco, Alberto La Mantia, Antonio, Laborante, Paolo, Lanzetta, Mattia, Marcigaglia, Cesare, Mariotti, Enrico, Martini, Leonardo, Mastropasqua, Simonetta, Morselli, Franco, Passani, Alfredo, Pece, Grazia, Pertile, Antonino, Pioppo, Cesare, Pirondini, Marcello, Prantera, Antonio, Rapisarda, Romano, Mario R., Giuseppe, Scarpa, Domenico, Schiano-Lomoriello, Vincenzo, Scorcia, Gianluca, Scuderi, Francesco, Semeraro, Franco, Spedale, Giovanni, Staurenghi, Tognetto, Daniele, Marco, Tosi, Giuseppe, Trabucchi, Fausto, Trivella, Edoardo, Villani, Andrea, Vento, Paolo, Vinciguerra, Alió, Jorge L., Alfonso Sanchez, Josè F., Francisco Arnalich Montiel, Katrin, Lorenz, Irina, Panova, Alena, Eremina, Giorgio, Ciprandi, Bandello F., Coassin M., Di Zazzo A., Rizzo S., Biagini I., Pozdeyeva N., Sinitsyn M., Verzin A., De Rosa P., Calabro F., Avitabile T., Bonfiglio V., Fasce F., Barraquer R., Mateu J.L., Kohnen T., Carnovali M., Malyugin B., Aragona P., Arvedi P., Cagini C., Caretti L., Cavallini G.M., Cillino S., Figini I., Franco L.M., La Mantia A., Laborante A., Lanzetta P., Marcigaglia M., Mariotti C., Martini E., Mastropasqua L., Morselli S., Passani F., Pece A., Pertile G., Pioppo A., Pirondini C., Prantera M., Rapisarda A., Romano M.R., Scarpa G., Schiano-Lomoriello D., Scorcia V., Scuderi G., Semeraro F., Spedale F., Staurenghi G., Tognetto D., Tosi M., Trabucchi G., Trivella F., Villani E., Vento A., Vinciguerra P., Alio J.L., Alfonso Sanchez J.F., Montiel F.A., Lorenz K., Panova I., Eremina A., Ciprandi G., Francesco, Bandello, Marco, Coassin, Antonio, Di Zazzo, Stanislao, Rizzo, Ilaria, Biagini, Nadezhda, Pozdeyeva, Maksim, Sinitsyn, Alexander, Verzin, Pasquale, De Rosa, Francesco, Calabrò, Teresio, Avitabile, Vincenza, Bonfiglio, Francesco, Fasce, Rafael, Barraquer, Josè Lamarca, Mateu, Thomas, Kohnen, Marino, Carnovali, Boris, Malyugin, Aragona, Pasquale, Arvedi, Paolo, Cagini, Carlo, Caretti, Luigi, Maria Cavallini, Gian, Cillino, Salvatore, Figini, Innocente, Marco Franco, Livio, La Mantia, Alberto, Laborante, Antonio, Lanzetta, Paolo, Marcigaglia, Mattia, Mariotti, Cesare, Martini, Enrico, Mastropasqua, Leonardo, Morselli, Simonetta, Passani, Franco, Pece, Alfredo, Pertile, Grazia, Pioppo, Antonino, Pirondini, Cesare, Prantera, Marcello, Rapisarda, Antonio, Romano, Mario R., Scarpa, Giuseppe, Schiano-Lomoriello, Domenico, Scorcia, Vincenzo, Scuderi, Gianluca, Semeraro, Francesco, Spedale, Franco, Staurenghi, Giovanni, Tognetto, Daniele, Tosi, Marco, Trabucchi, Giuseppe, Trivella, Fausto, Villani, Edoardo, Vento, Andrea, Vinciguerra, Paolo, Alió, Jorge L., Alfonso Sanchez, Josè F., Arnalich Montiel, Francisco, Lorenz, Katrin, Panova, Irina, Eremina, Alena, Ciprandi, Giorgio, Bandello, F., Coassin, M., Di Zazzo, A., Rizzo, S., Biagini, I., Pozdeyeva, N., Sinitsyn, M., Verzin, A., De Rosa, P., Calabro, F., Avitabile, T., Bonfiglio, V., Fasce, F., Barraquer, R., Mateu, J. L., Kohnen, T., Carnovali, M., Malyugin, B., Aragona, P., Arvedi, P., Cagini, C., Caretti, L., Cavallini, G. M., Cillino, S., Figini, I., Franco, L. M., La Mantia, A., Laborante, A., Lanzetta, P., Marcigaglia, M., Mariotti, C., Martini, E., Mastropasqua, L., Morselli, S., Passani, F., Pece, A., Pertile, G., Pioppo, A., Pirondini, C., Prantera, M., Rapisarda, A., Romano, M. R., Scarpa, G., Schiano-Lomoriello, D., Scorcia, V., Scuderi, G., Semeraro, F., Spedale, F., Staurenghi, G., Tognetto, D., Tosi, M., Trabucchi, G., Trivella, F., Villani, E., Vento, A., Vinciguerra, P., Alio, J. L., Alfonso Sanchez, J. F., Montiel, F. A., Lorenz, K., Panova, I., Eremina, A., and Ciprandi, G.
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medicine.medical_specialty ,medicine.medical_treatment ,Levofloxacin ,Article ,Dexamethasone ,Cataract ,03 medical and health sciences ,0302 clinical medicine ,Endophthalmitis ,Pharmacotherapy ,Postoperative Complications ,Internal medicine ,medicine ,Tobramycin ,Clinical endpoint ,Humans ,Endophthalmitis, Cataract, Intracameral cefuroxime ,Adverse effect ,business.industry ,Cataract surgery ,Intracameral cefuroxime ,medicine.disease ,not applicable ,Anti-Bacterial Agents ,Ophthalmology ,Italy ,Spain ,030221 ophthalmology & optometry ,Ophthalmic Solutions ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background: Cataract surgery is the most common operation performed worldwide. A fixed topical corticosteroid-antibiotic combination is usually prescribed in clinical practice for 2 or more weeks to treat post surgical inflammation and prevent infection. However, this protracted schedule may increase the incidence of corticosteroid-related adverse events and notably promote antibiotic resistance. Methods: This International, multicentre, randomized, blinded-assessor, parallel-group clinical study evaluated the non-inferiority of 1-week levofloxacin/dexamethasone eye drops, followed by 1-week dexamethasone alone, vs. 2-week gold-standard tobramycin/dexamethasone (one drop QID for all schedules) to prevent and treat ocular inflammation and prevent infection after uncomplicated cataract surgery. Non-inferiority was defined as the lower limit of the 95% confidence interval (CI) around a treatment difference >–10%. The study randomized 808 patients enrolled in 53 centres (Italy, Germany, Spain and Russia). The primary endpoint was the proportion of patients without anterior chamber inflammation on day 15 defined as the end of treatment. Endophthalmitis was the key secondary endpoint. This study is registered with EudraCT code: 2018-000286-36. Results: After the end of treatment, 95.2% of the patients in the test arm vs. 94.9% of the control arm had no signs of inflammation in the anterior chamber (difference between proportions of patients = 0.028; 95% CI: −0.0275/0.0331). No case of endophthalmitis was reported. No statistically significant difference was evident in any of the other secondary endpoints. Both treatments were well tolerated. Conclusions: Non-inferiority of the new short pharmacological strategy was proven. One week of levofloxacin/dexamethasone prevents infection, ensures complete control of inflammation in almost all patients and may contain antibiotic resistance.
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- 2020
37. Macular peeling-induced retinal damage: clinical and histopathological evaluation after using different dyes
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Cesare Mariotti, Mario R. Romano, Mariantonia Ferrara, Giovanni Cennamo, Gilda Cennamo, Stefania Staibano, Gennaro Ilardi, Barbara Parolini, Romano, Mario R., Ilardi, Gennaro, Ferrara, Mariantonia, Cennamo, Gilda, Parolini, Barbara, Mariotti, Cesare, Staibano, Stefania, and Cennamo, Giovanni
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Male ,Retinal Ganglion Cells ,Time Factors ,Visual acuity ,genetic structures ,Basement Membrane ,chemistry.chemical_compound ,0302 clinical medicine ,Vitrectomy ,Prospective Studies ,Fluorescein Angiography ,Coloring Agents ,Intraoperative Complications ,Aged, 80 and over ,Glial fibrillary acidic protein ,biology ,Inner limiting membrane ,Middle Aged ,Immunohistochemistry ,Sensory Systems ,medicine.anatomical_structure ,Female ,Trypan blue ,Epiretinal membrane ,medicine.symptom ,Pars plana ,medicine.medical_specialty ,Neurofilament ,Dye ,Fundus Oculi ,Ependymoglial Cells ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Ophthalmology ,medicine ,Humans ,Neurofilament protein ,Aged ,business.industry ,Müller cell ,Pars plana vitrectomy ,Macular peeling ,medicine.disease ,eye diseases ,chemistry ,030221 ophthalmology & optometry ,biology.protein ,sense organs ,Sensory System ,business ,Indocyanine green ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Purpose: To describe functional and histopathological findings after macular peeling using different dyes. Methods: Prospective, randomized, comparative, interventional, and immunohistochemical study. Forty-five eyes from 45 patients with idiopathic epiretinal membrane (ERM) underwent pars plana chromovitrectomy with ERM and inner limiting membrane (ILM) using trypan blue 0.15% + brilliant blue 0.05% + lutein 2% in group 1 (15 eyes), trypan blue 0.15% + brilliant blue 0.025% + polyethylene glycol 3350 4% in group 2 (15 eyes), and indocyanine green 0.05% in group 3 (15 eyes). We evaluated visual acuity (VA) and macular sensitivity (MS) preoperatively, 1, 3, and 6 months after surgery. The expression of glial fibrillary acidic protein (GFAP) and neurofilament protein (NF) was assessed immunohistochemically on the ILMs peeled as markers of glial and neuronal cells. Results: In group 1, both mean VA and MS were significantly better at 1 and 3 months after surgery (P < 0.05), whereas no significant difference was found after 6 months. GFAP and NF expression was significantly lower in group 1 (P < 0.05). Conclusions: The ERM/ILM peeling is thought to rip off the intraretinal tissue, based on the amounts of GFAP and NF in the specimens. The use of lutein dyes reduces iatrogenic stress to the retinal tissue and allows a faster functional recovery in the first 3 months after surgery, suggesting a less iatrogenic adhesion to the retinal tissue
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- 2018
38. Optical Coherence Tomography Angiography Findings in X-Linked Retinoschisis
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Rodolfo Mastropasqua, Lisa Toto, Luca Di Antonio, Ivana Antonucci, Luca Sorino, Maurizio Battaglia Parodi, Cesare Mariotti, Liborio Stuppia, Marta Di Nicola, Mastropasqua, Rodolfo, Toto, Lisa, Di Antonio, Luca, Parodi, Maurizio Battaglia, Sorino, Luca, Antonucci, Ivana, Stuppia, Liborio, Di Nicola, Marta, and Mariotti, Cesare
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Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Visual acuity ,Adolescent ,Fundus Oculi ,Retinoschisis ,Visual Acuity ,Retina ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Ophthalmology ,Electroretinography ,medicine ,Humans ,Fluorescein Angiography ,Child ,medicine.diagnostic_test ,business.industry ,Healthy subjects ,Retinal ,Optical coherence tomography angiography ,Female ,Middle Aged ,Pedigree ,Tomography ,Optical Coherence ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,030221 ophthalmology & optometry ,Surgery ,X-linked retinoschisis ,Retinoschisi ,medicine.symptom ,Acetazolamide ,business ,Tomography, Optical Coherence ,Human ,medicine.drug - Abstract
BACKGROUND AND OBJECTIVE: The aim of the study was to determine optical coherence tomography angiography (OCTA) findings and to identify mutations in the RS1 gene in a three-generation family with X-linked juvenile retinoschisis (XLRS). PATIENTS AND METHODS: Clinical and genetic assessments were performed in 12 family members. OCTA was performed at baseline (12 members including cases and carriers) and after acetazolamide administration (three cases). Twenty healthy subjects (20 eyes, controls) were chosen for comparison. Molecular genetic analysis of the RS1 gene was performed in all family members. RESULTS: Deep capillary plexus density was reduced in cases compared with controls ( P < .01) and was negatively related with retinal thickness ( P < .05). After treatment, retinal thickness decreased ( P < .05) and deep capillary plexus density increased ( P < .05) in cases. In three cases and in four carriers, p.Arg197 His mutation was found. CONCLUSION: OCTA shows reduced macular deep vessel density in patients with XLRS probably related to vessel displacement and disruption due to schitic cysts. [ Ophthalmic Surg Lasers Imaging Retina . 2018;49:e20–e31.]
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- 2018
39. LATE-ONSET OCULAR HYPERTENSION AFTER VITRECTOMY: A Multicenter Study of 6,048 Eyes
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Francesco Boscia, Antonio Longo, Matteo Fallico, Cesare Mariotti, Gilda Cennamo, Teresio Avitabile, Giovanni Li Volti, Andrea Russo, Vincenza Bonfiglio, Guglielmo Parisi, Claudio Bucolo, Mario R. Romano, Niccolò Castellino, Michele Reibaldi, Reibaldi, Michele, Avitabile, Teresio, Russo, Andrea, Bonfiglio, Vincenza, Mariotti, Cesare, Romano, Mario R, Boscia, Francesco, Cennamo, Gilda, Fallico, Matteo, Parisi, Guglielmo, Castellino, Niccolò, Bucolo, Claudio, Li Volti, Giovanni, Longo, Antonio, Reibaldi M., Avitabile T., Russo A., Bonfiglio V., Mariotti C., Romano M.R., Boscia F., Cennamo G., Fallico M., Parisi G., Castellino N., Bucolo C., Li Volti G., and Longo A.
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Male ,Pediatrics ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,MEDLINE ,Ocular hypertension ,Vitrectomy ,Late onset ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,Retinal Diseases ,Risk Factors ,Humans ,Medicine ,Intraocular Pressure ,Aged ,Retrospective Studies ,business.industry ,Incidence ,Medical record ,Incidence (epidemiology) ,Retrospective cohort study ,General Medicine ,medicine.disease ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Ophthalmology ,Italy ,Multicenter study ,030221 ophthalmology & optometry ,Female ,Ocular Hypertension ,business ,late-onset ocular hypertension ,Follow-Up Studies - Abstract
Purpose: To determine the incidence and risk factors for late-onset ocular hypertension (LOH) after vitrectomy. Methods: From the electronic medical records of consecutive patients who underwent primary vitrectomy, from January 2010 to December 2015, at 5 tertiary vitreoretinal centers in Italy, patient demographics, systemic, ophthalmic, operative, and postoperative data were drawn. Main outcome measure was the presence of LOH, defined as intraocular pressure >21 mmHg detected more than 2 months after vitrectomy on at least 2 consecutive visits. Results: Among 6,048 patients, LOH was found in 294 (4.9%) vitrectomized eyes and in 87 (1.4%) fellow eyes, (chi square; P < 0.001). Multivariable logistic regression showed that significant risk factors for developing LOH included intraoperative triamcinolone use (odds ratio [OR], 7.62; P < 0.001), longer axial length (OR, 1.55; P = 3.023), preoperative higher intraocular pressure (OR, 1.81; P = 0.003), and postvitrectomy pseudophakic/aphakic status (OR, 2.04; P < 0.001). Decision-tree analysis showed that the stronger predictor of LOH was intraoperative triamcinolone use (P < 0.001). Secondary predictors were a preoperative intraocular pressure more than 15 mmHg (P < 0.001) in eyes that use triamcinolone, and postvitrectomy pseudophakic/aphakic status (P = 0.007) in eyes that did not use triamcinolone. Conclusion: Late-onset ocular hypertension occurred in 4.9% of vitrectomized eyes. The main risk factors were intraoperative use of triamcinolone and postvitrectomy pseudophakic/aphakic status.
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- 2018
40. miRNAs in the vitreous humor of patients affected by idiopathic epiretinal membrane and macular hole
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Russo A, Ragusa M, Barbagallo C, Longo A, Avitabile T, Uva MG, Bonfiglio V, Toro M, Caltabiano R, Mariotti C, Boscia F, Romano MR, Di Pietro C, Barbagallo D, Purrello M, Reibaldi M, Russo, Andrea, Ragusa, Marco, Barbagallo, Cristina, Longo, Antonio, Avitabile, Teresio, Uva, Maurizio G, Bonfiglio, Vincenza, Toro, Mario D, Caltabiano, Rosario, Mariotti, Cesare, Boscia, Francesco, Romano, Mario R, Di Pietro, Cinzia, Barbagallo, Davide, Purrello, Michele, Reibaldi, Michele, Russo, A, Ragusa, M, Barbagallo, C, Longo, A, Avitabile, T, Uva, Mg, Bonfiglio, V, Toro, M, Caltabiano, R, Mariotti, C, Boscia, F, Romano, Mr, Di Pietro, C, Barbagallo, D, Purrello, M, and Reibaldi, M
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Male ,Multidisciplinary ,lcsh:R ,lcsh:Medicine ,Correction ,Down-Regulation ,Epiretinal Membrane ,Middle Aged ,Retinal Perforations ,Vitreous Body ,MicroRNAs ,Vitrectomy ,Humans ,lcsh:Q ,Female ,Prospective Studies ,lcsh:Science ,Transcriptome ,miRNA, macular hole - Abstract
The aim of the present study was to assess the expression of miRNAs in the Vitreous Humor (VH) of patients with Macular Hole (MH) and Epiretinal Membrane (ERM) compared to a control group.In this prospective, comparative study, 2-ml of VH was extracted from the core of the vitreous chamber in consecutive patients who underwent standard vitrectomy for ERM and MH. RNA was extracted and TaqMan® Low Density Arrays (TLDAs) were used to profile the transcriptome of 754 miRNAs. Results were validated by single TaqMan® assays. Finally, we created a biological network of differentially expressed miRNA targets and their nearest neighbors.Overall 10 eyes with MH, 16 eyes with idiopathic ERM and 6 controls were enrolled in the study. Profiling data identified 5 miRNAs differentially expressed in patients affected by MH and ERM with respect to controls. Four were downregulated (miR-19b, miR-24, miR-155, miR-451) and 1 was downregulated (miR-29a); TaqMan® assays of the VH of patients affected by MH and ERM, with respect to controls, showed that the most differentially expressed were miR-19b (FC -9.13, p:0.00004), mir-24 (FC -7.52, p:0.004) and miR-142-3p (FC -5.32, p:0.011). Our network data showed that deregulation of differentially expressed miRNAs induces an alteration of several pathways associated with genes involved in both MH and ERM.The present study suggests that disregulation of miR-19b, miR-24 and miR-142-3p, might be related to the alterations that characterize patients affected by MH and ERM.
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- 2017
41. Vitreous Substitutes: The Present and the Future
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Luigi Bartalena, Francesca Simonelli, Claudio Azzolini, Simone Donati, Cesare Mariotti, Giovanni Porta, Simona Maria Caprani, Giulia Airaghi, Riccardo Vinciguerra, Francesco Testa, Donati, Simone, Caprani, Simona Maria, Airaghi, Giulia, Vinciguerra, Riccardo, Bartalena, Luigi, Testa, Francesco, Mariotti, Cesare, Porta, Giovanni, Simonelli, Francesca, and Azzolini, Claudio
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medicine.medical_specialty ,Materials science ,genetic structures ,Prostheses and Implant ,Immunology and Microbiology (all) ,medicine.medical_treatment ,lcsh:Medicine ,Vitrectomy ,Biocompatible Materials ,Review Article ,General Biochemistry, Genetics and Molecular Biology ,Vitreous cavity ,Smart hydrogels ,medicine ,Animals ,Humans ,Biocompatible Material ,Biochemistry, Genetics and Molecular Biology (all) ,General Immunology and Microbiology ,Animal ,Medicine (all) ,lcsh:R ,General Medicine ,Vitreoretinal surgery ,Prostheses and Implants ,Biocompatible material ,eye diseases ,Surgery ,Vitreous Body ,sense organs ,Biomedical engineering ,Human - Abstract
Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. Finally, we describe the current studies on vitreous regeneration and cell cultures to create new intraocular gels with optimal biocompatibility and rheological properties. © 2014 Simone Donati et al.
- Published
- 2014
42. In-vivo visualization of the photoreceptors using Spectralis High Magnification Module imaging in central serous chorioretinopathy.
- Author
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Gujar R, Muzi A, Cagini C, Mariotti C, Piccolino FC, Chhablani J, and Lupidi M
- Abstract
Purpose: To visualize photoreceptors using the Spectralis High Magnification Module (HMM) in a case of central serous chorioretinopathy (CSCR) and to correlate the findings with those of optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A)., Observations: A 35-year-old Caucasian male presenting with chronic CSCR in the left eye was examined using HMM, OCT and OCT-A. The photoreceptors mosaic was assessed both in diseased and apparently uninvolved areas. A partial topographic correlation between the loss of photoreceptors on HMM images and an altered reflectivity of the photoreceptor layer on en-face OCT was noted. Interestingly, a correlation between the photoreceptor damage on HMM and choriocapillaris flow-void areas on OCT-A was seen., Conclusions and Importance: HMM is a non-invasive imaging modality, allowing the in-vivo visualization of photoreceptor damage in a diseased retina. A focal abnormal perfusion of the choriocapillaris might influence the integrity of the overlying photoreceptors in CSCR., Competing Interests: The following authors have no financial disclosures: RG, AM, CC, CM, FCP, JC, ML. The authors report no financial disclosures, grants, or any other supports relevant to this study., (© 2021 Published by Elsevier Inc.)
- Published
- 2021
- Full Text
- View/download PDF
43. Long-term control of non-infectious paediatric panuveitis refractory to traditional immunesuppressive therapy, successfully treated with Adalimumab (HumiraTM).
- Author
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Neri P, Eandi C, Arapi I, Posarelli C, Mariotti C, and Giovannini A
- Subjects
- Adalimumab, Adolescent, Child, Female, Humans, Male, Anti-Inflammatory Agents therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Panuveitis drug therapy
- Abstract
Objectives: The aim of this paper is to present two cases of severe idiopathic non-infectious paediatric panuveitis, unresponsive to traditional therapy, successfully treated with Adalimumab (HumiraTM, Abbott Pharmaceutical Inc.) in the long term., Methods: The data of the two cases are presented and the literature is reviewed., Results: At base line, case 1 had 0.2 in the RE and 0.5 in the LE, while case 2 had 0.5 and 0.4 in the RE and LE, respectively. The anterior chamber (AC) of case 1 had 3+ cells and 3+ flare in both eyes, as well as diffuse keratic precipitates (Kps). Case 2 presented 2+ cells and 3+ flare in both eyes, as well as tiny Kps in the inferior part of the endothelium. The Binocular Indirect Ophthalmoscopy (BIO) score was +2 in both eyes of case 1 and case 2 at first examination. After Adalimumab initiation, both patients presented a dramatic resolution of the ocular inflammation, as well as a rapid improvement of the BCVA. Case 1 had 0.8 and 1.0 in the RE and the LE, respectively, while case 2 presented 1.0 in both eyes. At the last visit, both patients presented a quiet uveitis and stable BCVA: case 1 had 0.8 and 1.0 in the RE and the LE, respectively, while case 2 presented 1.0 in both eyes. No side effects were recorded during this time., Conclusions: Adalimumab can be a promising drug for the therapy of severe, refractory paediatric uveitis, although further studies are needed on its application in uveitis.
- Published
- 2013
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