289 results on '"Mantovani, Lorenzo G"'
Search Results
2. Management strategies and clinical outcomes in patients with inferior vena cava thrombosis: Data from GARFIELD‐VTE
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Cohen, Omri, Ageno, Walter, Farjat, Alfredo E., Turpie, Alexander G.G., Weitz, Jeffrey I., Haas, Sylvia, Goto, Shinya, Goldhaber, Samuel Z., Angchaisuksiri, Pantep, Gibbs, Harry, MacCallum, Peter, Kayani, Gloria, Schellong, Sebastian, Bounameaux, Henri, Mantovani, Lorenzo G., Prandoni, Paolo, and Kakkar, Ajay K.
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- 2022
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3. Cost‐Effectiveness of the Early Arthritis Clinic Organizational Model
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Zanetti, Anna, Sakellariou, Garifallia, Zambon, Antonella, Carrara, Greta, Argnani, Lisa, Mantovani, Lorenzo G., Cortesi, Paolo A., Bugatti, Serena, Montecucco, Carlomaurizio, and Scirè, Carlo A.
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- 2023
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4. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
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Sawhney, Jitendra PS, Kothiwale, Veerappa A, Bisne, Vikas, Durgaprasad, Rajashekhar, Jadhav, Praveen, Chopda, Manoj, Vanajakshamma, Velam, Meena, Ramdhan, Vijayaraghavan, Govindan, Chawla, Kamaldeep, Allu, Jagan, Pieper, Karen S, Camm, A John, Kakkar, Ajay K, Bassand, Jean-Pierre, Fitzmaurice, David A, Goldhaber, Samuel Z, Goto, Shinya, Haas, Sylvia, Hacke, Werner, Mantovani, Lorenzo G, Misselwitz, Frank, Turpie, Alexander GG, van Eickels, Martin, Verheugt, Freek WA, Kayani, Gloria, Fox, Keith AA, Gersh, Bernard J, Luciardi, Hector Lucas, Gibbs, Harry, Brodmann, Marianne, Cools, Frank, Barretto, Antonio Carlos Pereira, Connolly, Stuart J, Spyropoulos, Alex, Eikelboom, John, Corbalan, Ramon, Hu, Dayi, Jansky, Petr, Nielsen, Jørn Dalsgaard, Ragy, Hany, Raatikainen, Pekka, Le Heuzey, Jean-Yves, Darius, Harald, Keltai, Matyas, Kakkar, Sanjay, Sawhney, Jitendra Pal Singh, Agnelli, Giancarlo, Ambrosio, Giuseppe, Koretsune, Yukihiro, Díaz, Carlos Jerjes Sánchez, Cate, Hugo Ten, Atar, Dan, Stepinska, Janina, Panchenko, Elizaveta, Lim, Toon Wei, Jacobson, Barry, Oh, Seil, Viñolas, Xavier, Rosenqvist, Marten, Steffel, Jan, Angchaisuksiri, Pantep, Oto, Ali, Parkhomenko, Alex, Mahmeed, Wael Al, Fitzmaurice, David, Hu, DY, Chen, KN, Zhao, YS, Zhang, HQ, Chen, JZ, Cao, SP, Wang, DW, Yang, YJ, Li, WH, Yin, YH, Tao, GZ, Yang, P, Chen, YM, He, SH, Wang, Ying, Wang, Yong, Fu, GS, Li, X, Wu, TG, Cheng, XS, Yan, XW, Zhao, RP, Chen, MS, Xiong, LG, and Chen, P
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Hematology ,Prevention ,Cardiovascular ,Clinical Research ,Heart Disease ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Aged ,Atrial Fibrillation ,Electrocardiography ,Female ,Follow-Up Studies ,Humans ,Incidence ,India ,Male ,Prevalence ,Prognosis ,Prospective Studies ,Registries ,Risk Assessment ,Risk Factors ,Survival Rate ,Thromboembolism ,Time Factors ,Anticoagulant therapy ,Arrhythmia ,Atrial fibrillation ,GARFIELD-AF ,GARFIELD-AF Investigators ,Cardiovascular System & Hematology - Abstract
BackgroundThe Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry.Methods and resultsA total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
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- 2018
5. Cancer‐Associated ThrOmboSIs – Patient‐Reported OutcoMes With RivarOxaban (COSIMO) – Baseline characteristics and clinical outcomes
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Maraveyas, Anthony, Beyer‐Westendorf, Jan, Lee, Agnes Y., Mantovani, Lorenzo G., De Sanctis, Yoriko, Abdelgawwad, Khaled, Fatoba, Samuel, Bach, Miriam, and Cohen, Alexander T
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- 2021
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6. Influence of body mass index on clinical outcomes in venous thromboembolism: Insights from GARFIELD‐VTE
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Weitz, Jeffrey I., Farjat, Alfredo E., Ageno, Walter, Turpie, Alexander G.G., Haas, Sylvia, Goto, Shinya, Goldhaber, Samuel Z., Angchaisuksiri, Pantep, Gibbs, Harry, MacCallum, Peter, Carrier, Marc, Kayani, Gloria, Schellong, Sebastian, Bounameaux, Henri, Mantovani, Lorenzo G., Prandoni, Paolo, and Kakkar, Ajay K.
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- 2021
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7. Epidemiology of SLE in Italy: an observational study using a primary care database
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Ferrara, Pietro, primary, Antonazzo, Ippazio C, additional, Zamparini, Manuel, additional, Fornari, Carla, additional, Borrelli, Cristiana, additional, Boarino, Silvia, additional, Bettiol, Alessandra, additional, Mattioli, Irene, additional, Palladino, Pasquale, additional, Zanzottera Ferrari, Elena, additional, Emmi, Giacomo, additional, Mantovani, Lorenzo G, additional, and Mazzaglia, Giampiero, additional
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- 2024
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8. Anticoagulant treatment for venous thromboembolism: A pooled analysis and additional results of the XALIA and XALIA‐LEA noninterventional studies
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Haas, Sylvia, Mantovani, Lorenzo G., Kreutz, Reinhold, Monje, Danja, Schneider, Jonas, Zell, Elizabeth R., Tamm, Miriam, Gebel, Martin, Bugge, Jörg‐Peter, Ageno, Walter, and Turpie, Alexander G.G.
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- 2021
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9. Provoked versus unprovoked venous thromboembolism: Findings from GARFIELD‐VTE
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Ageno, Walter, Farjat, Alfredo, Haas, Sylvia, Weitz, Jeffrey I., Goldhaber, Samuel Z., Turpie, Alexander G.G., Goto, Shinya, Angchaisuksiri, Pantep, Dalsgaard Nielsen, Joern, Kayani, Gloria, Schellong, Sebastian, Bounameaux, Henri, Mantovani, Lorenzo G., Prandoni, Paolo, and Kakkar, Ajay K.
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- 2021
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10. Corrigendum: Time-Trends in Air Pollution Impact on Health in Italy, 1990-2019: An Analysis from the Global Burden of Disease Study 2019
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Conti, Sara, Fornari, Carla, Ferrara, Pietro, Antonazzo, Ippazio C., Madotto, Fabiana, Traini, Eugenio, Levi, Miriam, Cernigliaro, Achille, Armocida, Benedetta, Bragazzi, Nicola L., Cadum, Ennio, Carugno, Michele, Crotti, Giacomo, Deandrea, Silvia, Cortesi, Paolo A., Guido, Davide, Iavicoli, Ivo, Iavicoli, Sergio, La Vecchia, Carlo, Lauriola, Paolo, Michelozzi, Paola, Scondotto, Salvatore, Stafoggia, Massimo, Violante, Francesco S., Abbafati, Cristiana, Albano, Luciana, Barone-Adesi, Francesco, Biondi, Antonio, Bosetti, Cristina, Buonsenso, Danilo, Carreras, Giulia, Castelpietra, Giulio, Catapano, Alberico, Cattaruzza, Maria S., Corso, Barbara, Damiani, Giovanni, Esposito, Francesco, Gallus, Silvano, Golinelli, Davide, Hay, Simon I., Isola, Gaetano, Ledda, Caterina, Mondello, Stefania, Pedersini, Paolo, Pensato, Umberto, Perico, Norberto, Remuzzi, Giuseppe, Sanmarchi, Francesco, Santoro, Rocco, Simonetti, Biagio, Unim, Brigid, Vacante, Marco, Veroux, Massimiliano, Villafañe, Jorge H., Monasta, Lorenzo, Mantovani, Lorenzo G., Conti, Sara, Fornari, Carla, Ferrara, Pietro, Antonazzo, Ippazio C., Madotto, Fabiana, Traini, Eugenio, Levi, Miriam, Cernigliaro, Achille, Armocida, Benedetta, Bragazzi, Nicola L., Cadum, Ennio, Carugno, Michele, Crotti, Giacomo, Deandrea, Silvia, Cortesi, Paolo A., Guido, Davide, Iavicoli, Ivo, Iavicoli, Sergio, La Vecchia, Carlo, Lauriola, Paolo, Michelozzi, Paola, Scondotto, Salvatore, Stafoggia, Massimo, Violante, Francesco S., Abbafati, Cristiana, Albano, Luciana, Barone-Adesi, Francesco, Biondi, Antonio, Bosetti, Cristina, Buonsenso, Danilo, Carreras, Giulia, Castelpietra, Giulio, Catapano, Alberico, Cattaruzza, Maria S., Corso, Barbara, Damiani, Giovanni, Esposito, Francesco, Gallus, Silvano, Golinelli, Davide, Hay, Simon I., Isola, Gaetano, Ledda, Caterina, Mondello, Stefania, Pedersini, Paolo, Pensato, Umberto, Perico, Norberto, Remuzzi, Giuseppe, Sanmarchi, Francesco, Santoro, Rocco, Simonetti, Biagio, Unim, Brigid, Vacante, Marco, Veroux, Massimiliano, Villafañe, Jorge H., Monasta, Lorenzo, and Mantovani, Lorenzo G.
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[This corrects the article DOI: 10.3389/ijph.2023.1605959.].
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- 2024
11. Epidemiology of SLE in Italy: an observational study using a primary care database
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Ferrara, P, Antonazzo, I, Zamparini, M, Fornari, C, Borrelli, C, Boarino, S, Bettiol, A, Mattioli, I, Palladino, P, Zanzottera Ferrari, E, Emmi, G, Mantovani, L, Mazzaglia, G, Ferrara, Pietro, Antonazzo, Ippazio C, Zamparini, Manuel, Fornari, Carla, Borrelli, Cristiana, Boarino, Silvia, Bettiol, Alessandra, Mattioli, Irene, Palladino, Pasquale, Zanzottera Ferrari, Elena, Emmi, Giacomo, Mantovani, Lorenzo G, Mazzaglia, Giampiero, Ferrara, P, Antonazzo, I, Zamparini, M, Fornari, C, Borrelli, C, Boarino, S, Bettiol, A, Mattioli, I, Palladino, P, Zanzottera Ferrari, E, Emmi, G, Mantovani, L, Mazzaglia, G, Ferrara, Pietro, Antonazzo, Ippazio C, Zamparini, Manuel, Fornari, Carla, Borrelli, Cristiana, Boarino, Silvia, Bettiol, Alessandra, Mattioli, Irene, Palladino, Pasquale, Zanzottera Ferrari, Elena, Emmi, Giacomo, Mantovani, Lorenzo G, and Mazzaglia, Giampiero
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Objectives To estimate the incidence and prevalence of SLE in Italy, and to describe the demographic and clinical characteristics of patients with newly diagnosed SLE. Methods A retrospective cohort study was conducted using The Health Improvement Network general practice database in Italy, encompassing data from 634 753 people. SLE cases were identified over the period 2017-2022, employing three alternative definitions to provide a more detailed understanding of SLE characteristics. Incidence rates were expressed as cases per 100 000 person-years and prevalence as cases per 100 000 people. Demographic and clinical characteristics of incident SLE cases were also studied. Results From 2017 to 2022, a total of 191 incident and 1385 prevalent cases were identified under our first definition. In 2022, the incidence rate was 6.51 cases (95% CI 6.29 to 6.74) per 100 000 person-years, and the prevalence 60.57 (95% CI 59.89 to 61.25) per 100 000 people, being the prevalence five times higher in women compared with men. Both estimates have trended upwards since 2017. A geographical variation across the country was also seen. The demographic and clinical characteristics of incident SLE cases were described, while the potential associations of SLE incidence with some pre-existing conditions were observed, such as chronic kidney disease, chronic hepatic disease, rheumatoid arthritis and Sjogren's syndrome. Conclusions The results of this nationwide study, the first conducted in Italy, showed that the incidence of SLE has increased in Italy in recent years. Age, sex, and area of residence strongly correlate with the epidemiology of this condition.
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- 2024
12. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study
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Roth, Gregory A., Mensah, George A., Johnson, Catherine O., Addolorato, Giovanni, Ammirati, Enrico, Baddour, Larry M., Barengo, Noel C., Beaton, Andrea, Benjamin, Emelia J., Benziger, Catherine P., Bonny, Aime, Brauer, Michael, Brodmann, Marianne, Cahill, Thomas J., Carapetis, Jonathan R., Catapano, Alberico L., Chugh, Sumeet, Cooper, Leslie T., Coresh, Josef, Criqui, Michael H., DeCleene, Nicole K., Eagle, Kim A., Emmons-Bell, Sophia, Feigin, Valery L., Fernández-Sola, Joaquim, Fowkes, F. Gerry R., Gakidou, Emmanuela, Grundy, Scott M., He, Feng J., Howard, George, Hu, Frank, Inker, Lesley, Karthikeyan, Ganesan, Kassebaum, Nicholas J., Koroshetz, Walter J., Lavie, Carl, Lloyd-Jones, Donald, Lu, Hong S., Mirijello, Antonio, Misganaw, Awoke T., Mokdad, Ali H., Moran, Andrew E., Muntner, Paul, Narula, Jagat, Neal, Bruce, Ntsekhe, Mpiko, Oliveira, Gláucia M.M., Otto, Catherine M., Owolabi, Mayowa O., Pratt, Michael, Rajagopalan, Sanjay, Reitsma, Marissa B., Ribeiro, Antonio Luiz P., Rigotti, Nancy A., Rodgers, Anthony, Sable, Craig A., Shakil, Saate S., Sliwa, Karen, Stark, Benjamin A., Sundström, Johan, Timpel, Patrick, Tleyjeh, Imad I., Valgimigli, Marco, Vos, Theo, Whelton, Paul K., Yacoub, Magdi, Zuhlke, Liesl J., Abbasi-Kangevari, Mohsen, Abdi, Alireza, Abedi, Aidin, Aboyans, Victor, Abrha, Woldu A., Abu-Gharbieh, Eman, Abushouk, Abdelrahman I., Acharya, Dilaram, Adair, Tim, Adebayo, Oladimeji M., Ademi, Zanfina, Advani, Shailesh M., Afshari, Khashayar, Afshin, Ashkan, Agarwal, Gina, Agasthi, Pradyumna, Ahmad, Sohail, Ahmadi, Sepideh, Ahmed, Muktar B., Aji, Budi, Akalu, Yonas, Akande-Sholabi, Wuraola, Aklilu, Addis, Akunna, Chisom J., Alahdab, Fares, Al-Eyadhy, Ayman, Alhabib, Khalid F., Alif, Sheikh M., Alipour, Vahid, Aljunid, Syed M., Alla, François, Almasi-Hashiani, Amir, Almustanyir, Sami, Al-Raddadi, Rajaa M., Amegah, Adeladza K., Amini, Saeed, Aminorroaya, Arya, Amu, Hubert, Amugsi, Dickson A., Ancuceanu, Robert, Anderlini, Deanna, Andrei, Tudorel, Andrei, Catalina Liliana, Ansari-Moghaddam, Alireza, Anteneh, Zelalem A., Antonazzo, Ippazio Cosimo, Antony, Benny, Anwer, Razique, Appiah, Lambert T., Arabloo, Jalal, Ärnlöv, Johan, Artanti, Kurnia D., Ataro, Zerihun, Ausloos, Marcel, Avila-Burgos, Leticia, Awan, Asma T., Awoke, Mamaru A., Ayele, Henok T., Ayza, Muluken A., Azari, Samad, B, Darshan B., Baheiraei, Nafiseh, Baig, Atif A., Bakhtiari, Ahad, Banach, Maciej, Banik, Palash C., Baptista, Emerson A., Barboza, Miguel A., Barua, Lingkan, Basu, Sanjay, Bedi, Neeraj, Béjot, Yannick, Bennett, Derrick A., Bensenor, Isabela M., Berman, Adam E., Bezabih, Yihienew M., Bhagavathula, Akshaya S., Bhaskar, Sonu, Bhattacharyya, Krittika, Bijani, Ali, Bikbov, Boris, Birhanu, Mulugeta M., Boloor, Archith, Brant, Luisa C., Brenner, Hermann, Briko, Nikolay I., Butt, Zahid A., Caetano dos Santos, Florentino Luciano, Cahill, Leah E., Cahuana-Hurtado, Lucero, Cámera, Luis A., Campos-Nonato, Ismael R., Cantu-Brito, Carlos, Car, Josip, Carrero, Juan J., Carvalho, Felix, Castañeda-Orjuela, Carlos A., Catalá-López, Ferrán, Cerin, Ester, Charan, Jaykaran, Chattu, Vijay Kumar, Chen, Simiao, Chin, Ken L., Choi, Jee-Young J., Chu, Dinh-Toi, Chung, Sheng-Chia, Cirillo, Massimo, Coffey, Sean, Conti, Sara, Costa, Vera M., Cundiff, David K., Dadras, Omid, Dagnew, Baye, Dai, Xiaochen, Damasceno, Albertino A.M., Dandona, Lalit, Dandona, Rakhi, Davletov, Kairat, De la Cruz-Góngora, Vanessa, De la Hoz, Fernando P., De Neve, Jan-Walter, Denova-Gutiérrez, Edgar, Derbew Molla, Meseret, Derseh, Behailu T., Desai, Rupak, Deuschl, Günther, Dharmaratne, Samath D., Dhimal, Meghnath, Dhungana, Raja Ram, Dianatinasab, Mostafa, Diaz, Daniel, Djalalinia, Shirin, Dokova, Klara, Douiri, Abdel, Duncan, Bruce B., Duraes, Andre R., Eagan, Arielle W., Ebtehaj, Sanam, Eftekhari, Aziz, Eftekharzadeh, Sahar, Ekholuenetale, Michael, El Nahas, Nevine, Elgendy, Islam Y., Elhadi, Muhammed, El-Jaafary, Shaimaa I., Esteghamati, Sadaf, Etisso, Atkilt E., Eyawo, Oghenowede, Fadhil, Ibtihal, Faraon, Emerito Jose A., Faris, Pawan S., Farwati, Medhat, Farzadfar, Farshad, Fernandes, Eduarda, Fernandez Prendes, Carlota, Ferrara, Pietro, Filip, Irina, Fischer, Florian, Flood, David, Fukumoto, Takeshi, Gad, Mohamed M., Gaidhane, Shilpa, Ganji, Morsaleh, Garg, Jalaj, Gebre, Abadi K., Gebregiorgis, Birhan G., Gebregzabiher, Kidane Z., Gebremeskel, Gebreamlak G., Getacher, Lemma, Obsa, Abera Getachew, Ghajar, Alireza, Ghashghaee, Ahmad, Ghith, Nermin, Giampaoli, Simona, Gilani, Syed Amir, Gill, Paramjit S., Gillum, Richard F., Glushkova, Ekaterina V., Gnedovskaya, Elena V., Golechha, Mahaveer, Gonfa, Kebebe B., Goudarzian, Amir Hossein, Goulart, Alessandra C., Guadamuz, Jenny S., Guha, Avirup, Guo, Yuming, Gupta, Rajeev, Hachinski, Vladimir, Hafezi-Nejad, Nima, Haile, Teklehaimanot G., Hamadeh, Randah R., Hamidi, Samer, Hankey, Graeme J., Hargono, Arief, Hartono, Risky K., Hashemian, Maryam, Hashi, Abdiwahab, Hassan, Shoaib, Hassen, Hamid Y., Havmoeller, Rasmus J., Hay, Simon I., Hayat, Khezar, Heidari, Golnaz, Herteliu, Claudiu, Holla, Ramesh, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Huang, Junjie, Humayun, Ayesha, Iavicoli, Ivo, Ibeneme, Charles U., Ibitoye, Segun E., Ilesanmi, Olayinka S., Ilic, Irena M., Ilic, Milena D., Iqbal, Usman, Irvani, Seyed Sina N., Islam, Sheikh Mohammed Shariful, Islam, Rakibul M., Iso, Hiroyasu, Iwagami, Masao, Jain, Vardhmaan, Javaheri, Tahereh, Jayapal, Sathish Kumar, Jayaram, Shubha, Jayawardena, Ranil, Jeemon, Panniyammakal, Jha, Ravi P., Jonas, Jost B., Jonnagaddala, Jitendra, Joukar, Farahnaz, Jozwiak, Jacek J., Jürisson, Mikk, Kabir, Ali, Kahlon, Tanvir, Kalani, Rizwan, Kalhor, Rohollah, Kamath, Ashwin, Kamel, Ibrahim, Kandel, Himal, Kandel, Amit, Karch, André, Kasa, Ayele Semachew, Katoto, Patrick D.M.C., Kayode, Gbenga A., Khader, Yousef S., Khammarnia, Mohammad, Khan, Muhammad S., Khan, Md Nuruzzaman, Khan, Maseer, Khan, Ejaz A., Khatab, Khaled, Kibria, Gulam M.A., Kim, Yun Jin, Kim, Gyu Ri, Kimokoti, Ruth W., Kisa, Sezer, Kisa, Adnan, Kivimäki, Mika, Kolte, Dhaval, Koolivand, Ali, Korshunov, Vladimir A., Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Vijay, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kulkarni, Vaman, Kumar, G. Anil, Kumar, Nithin, Kurmi, Om P., Kusuma, Dian, Kwan, Gene F., La Vecchia, Carlo, Lacey, Ben, Lallukka, Tea, Lan, Qing, Lasrado, Savita, Lassi, Zohra S., Lauriola, Paolo, Lawrence, Wayne R., Laxmaiah, Avula, LeGrand, Kate E., Li, Ming-Chieh, Li, Bingyu, Li, Shanshan, Lim, Stephen S., Lim, Lee-Ling, Lin, Hualiang, Lin, Ziqiang, Lin, Ro-Ting, Liu, Xuefeng, Lopez, Alan D., Lorkowski, Stefan, Lotufo, Paulo A., Lugo, Alessandra, M, Nirmal K., Madotto, Fabiana, Mahmoudi, Morteza, Majeed, Azeem, Malekzadeh, Reza, Malik, Ahmad A., Mamun, Abdullah A., Manafi, Navid, Mansournia, Mohammad Ali, Mantovani, Lorenzo G., Martini, Santi, Mathur, Manu R., Mazzaglia, Giampiero, Mehata, Suresh, Mehndiratta, Man Mohan, Meier, Toni, Menezes, Ritesh G., Meretoja, Atte, Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Michalek, Irmina Maria, Miller, Ted R., Mirrakhimov, Erkin M., Mirzaei, Hamed, Moazen, Babak, Moghadaszadeh, Masoud, Mohammad, Yousef, Mohammad, Dara K., Mohammed, Shafiu, Mohammed, Mohammed A., Mokhayeri, Yaser, Molokhia, Mariam, Montasir, Ahmed A., Moradi, Ghobad, Moradzadeh, Rahmatollah, Moraga, Paula, Morawska, Lidia, Moreno Velásquez, Ilais, Morze, Jakub, Mubarik, Sumaira, Muruet, Walter, Musa, Kamarul Imran, Nagarajan, Ahamarshan J., Nalini, Mahdi, Nangia, Vinay, Naqvi, Atta Abbas, Narasimha Swamy, Sreenivas, Nascimento, Bruno R., Nayak, Vinod C., Nazari, Javad, Nazarzadeh, Milad, Negoi, Ruxandra I., Neupane Kandel, Sandhya, Nguyen, Huong L.T., Nixon, Molly R., Norrving, Bo, Noubiap, Jean Jacques, Nouthe, Brice E., Nowak, Christoph, Odukoya, Oluwakemi O., Ogbo, Felix A., Olagunju, Andrew T., Orru, Hans, Ortiz, Alberto, Ostroff, Samuel M., Padubidri, Jagadish Rao, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Parekh, Utsav, Park, Eun-Cheol, Parvizi, Mojtaba, Pashazadeh Kan, Fatemeh, Patel, Urvish K., Pathak, Mona, Paudel, Rajan, Pepito, Veincent Christian F., Perianayagam, Arokiasamy, Perico, Norberto, Pham, Hai Q., Pilgrim, Thomas, Piradov, Michael A., Pishgar, Farhad, Podder, Vivek, Polibin, Roman V., Pourshams, Akram, Pribadi, Dimas R.A., Rabiee, Navid, Rabiee, Mohammad, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Ur Rahman, Mohammad Hifz, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rakovac, Ivo, Ram, Pradhum, Ramalingam, Sudha, Rana, Juwel, Ranasinghe, Priyanga, Rao, Sowmya J., Rathi, Priya, Rawal, Lal, Rawasia, Wasiq F., Rawassizadeh, Reza, Remuzzi, Giuseppe, Renzaho, Andre M.N., Rezapour, Aziz, Riahi, Seyed Mohammad, Roberts-Thomson, Ross L., Roever, Leonardo, Rohloff, Peter, Romoli, Michele, Roshandel, Gholamreza, Rwegerera, Godfrey M., Saadatagah, Seyedmohammad, Saber-Ayad, Maha M., Sabour, Siamak, Sacco, Simona, Sadeghi, Masoumeh, Saeedi Moghaddam, Sahar, Safari, Saeed, Sahebkar, Amirhossein, Salehi, Sana, Salimzadeh, Hamideh, Samaei, Mehrnoosh, Samy, Abdallah M., Santos, Itamar S., Santric-Milicevic, Milena M., Sarrafzadegan, Nizal, Sarveazad, Arash, Sathish, Thirunavukkarasu, Sawhney, Monika, Saylan, Mete, Schmidt, Maria I., Schutte, Aletta E., Senthilkumaran, Subramanian, Sepanlou, Sadaf G., Sha, Feng, Shahabi, Saeed, Shahid, Izza, Shaikh, Masood A., Shamali, Mahdi, Shamsizadeh, Morteza, Shawon, Md Shajedur Rahman, Sheikh, Aziz, Shigematsu, Mika, Shin, Min-Jeong, Shin, Jae Il, Shiri, Rahman, Shiue, Ivy, Shuval, Kerem, Siabani, Soraya, Siddiqi, Tariq J., Silva, Diego A.S., Singh, Jasvinder A., Mtech, Ambrish Singh, Skryabin, Valentin Y., Skryabina, Anna A., Soheili, Amin, Spurlock, Emma E., Stockfelt, Leo, Stortecky, Stefan, Stranges, Saverio, Suliankatchi Abdulkader, Rizwan, Tadbiri, Hooman, Tadesse, Eyayou G., Tadesse, Degena B., Tajdini, Masih, Tariqujjaman, Md, Teklehaimanot, Berhane F., Temsah, Mohamad-Hani, Tesema, Ayenew K., Thakur, Bhaskar, Thankappan, Kavumpurathu R., Thapar, Rekha, Thrift, Amanda G., Timalsina, Binod, Tonelli, Marcello, Touvier, Mathilde, Tovani-Palone, Marcos R., Tripathi, Avnish, Tripathy, Jaya P., Truelsen, Thomas C., Tsegay, Guesh M., Tsegaye, Gebiyaw W., Tsilimparis, Nikolaos, Tusa, Biruk S., Tyrovolas, Stefanos, Umapathi, Krishna Kishore, Unim, Brigid, Unnikrishnan, Bhaskaran, Usman, Muhammad S., Vaduganathan, Muthiah, Valdez, Pascual R., Vasankari, Tommi J., Velazquez, Diana Z., Venketasubramanian, Narayanaswamy, Vu, Giang T., Vujcic, Isidora S., Waheed, Yasir, Wang, Yanzhong, Wang, Fang, Wei, Jingkai, Weintraub, Robert G., Weldemariam, Abrha H., Westerman, Ronny, Winkler, Andrea S., Wiysonge, Charles S., Wolfe, Charles D.A., Wubishet, Befikadu Legesse, Xu, Gelin, Yadollahpour, Ali, Yamagishi, Kazumasa, Yan, Lijing L., Yandrapalli, Srikanth, Yano, Yuichiro, Yatsuya, Hiroshi, Yeheyis, Tomas Y., Yeshaw, Yigizie, Yilgwan, Christopher S., Yonemoto, Naohiro, Yu, Chuanhua, Yusefzadeh, Hasan, Zachariah, Geevar, Zaman, Sojib Bin, Zaman, Muhammed S., Zamanian, Maryam, Zand, Ramin, Zandifar, Alireza, Zarghi, Afshin, Zastrozhin, Mikhail S., Zastrozhina, Anasthasia, Zhang, Zhi-Jiang, Zhang, Yunquan, Zhang, Wangjian, Zhong, Chenwen, Zou, Zhiyong, Zuniga, Yves Miel H., Murray, Christopher J.L., Fuster, Valentin, Barengo, Noël C., Beaton, Andrea Z., Bonny, Aimé, Carapetis, Jonathan, Chugh, Sumeet S., Criqui, Michael, DeCleene, Nicole, Fernández-Solà, Joaquim, Fowkes, Gerry, Kassebaum, Nicholas, Koroshetz, Walter, Temesgen, Awoke Misganaw, Mokdad, Ali, Moraes de Oliveira, Glaucia, Otto, Catherine, Owolabi, Mayowa, Reitsma, Marissa, Rigotti, Nancy, Sable, Craig, Shakil, Saate, Sliwa-Hahnle, Karen, Stark, Benjamin, Tleyjeh, Imad M., Zuhlke, Liesl, and Murray, Christopher
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- 2020
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13. Anticoagulation therapy patterns for acute treatment of venous thromboembolism in GARFIELD‐VTE patients
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Haas, Sylvia, Ageno, Walter, Weitz, Jeffrey I., Goldhaber, Samuel Z., Turpie, Alexander G.G., Goto, Shinya, Angchaisuksiri, Pantep, Dalsgaard Nielsen, Joern, Kayani, Gloria, Zaghdoun, Audrey, Farjat, Alfredo E., Schellong, Sebastian, Bounameaux, Henri, Mantovani, Lorenzo G., Prandoni, Paolo, Kakkar, Ajay K., Loualidi, Ab, Colak, Abdurrahim, Bezuidenhout, Abraham, Abdool‐Carrim, Abu, Azeddine, Addala, Beyers, Adriaan, Dees, Adriaan, Mohamed, Ahmed, Aksoy, Ahmet, Abiko, Akihiko, Watanabe, Akinori, Krichell, Alan, Fernandez, Alberto Alfredo, Tosetto, Alberto, Khotuntsov, Alexey, Oropallo, Alisha, Slocombe, Alison, Kelly, Allan, Clark, Amanda, Gad, Amr, Arouni, Amy, Schmidt, Andor, Berni, Andrea, Kleiban, Andres Javier, Machowski, Andrew, Kazakov, Andrey, Galvez, Angel, Lockman, Ann, Falanga, Anna, Chauhan, Anoop, Riera‐Mestre, Antoni, Mazzone, Antonino, D'Angelo, Armando, Herdy, Artur, Kato, Atsushi, Ebrahim, Ayman Abd Elhamid, Salem, Mahmoud, Husin, Azlan, Erdelyi, Barbara, Jacobson, Barry, Amann‐Vesti, Beatrice, Battaloglu, Bektas, Wilson, Benedicte, Cosmi, Benilde, Francois, Bergmann Jean, Toufek, Berremeli, Hunt, Beverley, Natha, Bhavesh, Mustafa, Bisher, Kho, Bonnie Chi Shan, Carine, Boulon, Zidel, Brian, Dominique, Brisot, Christophe, Brousse, Trimarco, Bruno, Luo, Canhua, Alberto Cuneo, Carlos, Sanchez Diaz, Carlos Jerjes, Schwencke, Carsten, Cader, Cas, Yavuz, Celal, Javier Zaidman, Cesar, Lunn, Charles, Wu, Chau‐Chung, Toh, Cheng Hock, Chiang, Chern‐En, Elisa, Chevrier, Hsia, Chien‐Hsun, Huang, Chien‐Lung, Kwok, Chi‐Hang Kevin, Wu, Chih‐Cheng, Huang, Chi‐Hung, Ward, Chris, Opitz, Christian, Jeanneret‐Gris, Christina, Ha, Chung Yin, Huang, Chun‐Yao, Bidi, Claude Luyeye, Smith, Clifford, Brauer, Cornelia, Lodigiani, Corrado, Francis, Couturaud, Wu, Cynthia, Staub, Daniel, Theodoro, Daniel, Poli, Daniela, Acevedo, Riesco, Adler, David, Jimenez, David, Keeling, David, Scott, David, Imberti, Davide, Creagh, Desmond, Helene, Desmurs‐Clavel, Hagemann, Dirk, Le Roux, Dirk, Skowasch, Dirk, Belenky, Dmitry, Dorokhov, Dmitry, Petrov, Dmitry, Zateyshchikov, Dmitry, Prisco, Domenico, Møller, Dorthe, Kucera, Dusan, Esheiba, Ehab M., Panchenko, Elizaveta, Dominique, Elkouri, Dogan, Emre, Kubat, Emre, Diaz Diaz, Enrique, Tse, Eric Wai Choi, Yeo, Erik, Hashas, Erman, Grochenig, Ernst, Tiraferri, Eros, Blessing, Erwin, Michèle, Escande Orthlieb, Usandizaga, Esther, Porreca, Ettore, Ferroni, Fabian, Nicolas, Falvo, Ayala‐Paredes, Félix, Koura, Firas, Henry, Fitjerald, Cosmi, Franco, Erdkamp, Frans, Kamalov, Gadel, Dalmau, Garcia‐Bragado, Damien, Garrigues, Klein, Garry, Shah, Gaurand, Hollanders, Geert, Merli, Geno, Plassmann, Georg, Platt, George, Poirier, Germain, Sokurenko, German, Haddad, Ghassan, Ali, Gholam, Agnelli, Giancarlo, Gan, Gin Gin, Kaye‐Eddie, Grace, Le Gal, Gregoire, Allen, Gregory, Llamas Esperón, Guillermo Antonio, Jean‐Paul, Guillot, Gerofke, Hagen, Elali, Hallah, Burianova, Hana, Ohler, Hans‐Juergen, Wang, Haofu, Darius, Harald, Gogia, Harinder S., Striekwold, Harry, Gibbs, Harry, Hasanoglu, Hatice, Turker, Hatice, Franow, Hendrik, De Raedt, Herbert, Schroe, Herman, ElDin, Hesham Salah, Zidan, Hesham, Nakamura, Hiroaki, Kim, Ho Young, Lawall, Holger, Zhu, Hong, Tian, Hongyan, Yhim, Ho‐Young, ten Cate, Hugo, Hwang, Hun Gyu, Shim, Hyeok, Kim, Igor, Libov, Igor, Sonkin, Igor, Suchkov, Igor, Song, Ik‐Chan, Kiris, Ilker, Staroverov, Ilya, Looi, Irene, De La Azuela Tenorio, Isabel M, Savas, Ismail, Gordeev, Ivan, Podpera, Ivo, Lee, Jae Hoon, Sathar, Jameela, Welker, James, Beyer‐Westendorf, Jan, Kvasnicka, Jan, Vanwelden, Jan, Kim, JangYong, Svobodova, Jaromira, Gujral, Jaspal, Marino, Javier, Galvar, Javier Tristan, Kassis, Jeannine, Kuo, Jen‐Yuan, Shih, Jhih‐Yuan, Kwon, JiHyun, Joh, Jin Hyun, Park, Jin Hyun, Kim, Jin Seok, Yang, Jinghua, Krupicka, Jiri, Lastuvka, Jiri, Pumprla, Jiri, Vesely, Jiri, Carlos Souto, Joan, Antônio Correa, João, Duchateau, Johan, Fletcher, John Perry, del Toro, Jorge, Chavez Paez, Jorge Guillermo, Araujo Filho, Jose Dalmo, Saraiva, Jose, Diaz Peromingo, Jose Antonio, Gomez Lara, Jose, Luis Fedele, Jose, Maria Surinach, Jose, Chacko, Joseph, Antonio Muntaner, Juan, Álvarez Benitez, Juan Carlos, Hoyos Abril, Juan Moreno, Humphrey, Julian, Bono, Julio, Kanda, Junji, Boondumrongsagoon, Juree, Yiu, Kai Hang, Chansung, Kanchana, Boomars, Karin, Burbury, Kate, Kondo, Katsuhiro, Karaarslan, Kemal, Takeuchi, Kensuke, Kroeger, Knut, Zrazhevskiy, Konstantin, Svatopluk, Koscál, Shyu, Kou‐Gi, Vandenbosch, Kristel, Chang, Kuan‐Cheng, Chiu, Kuan‐Ming, Jean‐Manuel, Kubina, Wern, Kwan Jing, Ueng, Kwo‐Chang, Norasetthada, Lalita, Binet, Laure, Chew, Lee Ping, Zhang, Lei, Cristina, Leone Maria, Tick, Lidwine, Beatriz Schiavi, Lilia, Wong, Lily Lee Lee, Borges, Lohana, Botha, Louis, Capiau, Luc, Timmermans, Luc, Eduardo López, Luciano, Ria, Luigi, Hernandez Blasco, Luis Manuel, Guzman, Luis Alberto, Flota Cervera, Luis, Isabelle, Mahe, Monreal Bosch, Manuel, de los Rios Ibarra, Manuel, Núñez Fernandez, Manuel, Carrier, Marc, Raul Barrionuevo, Marcelo, Alcocer Gamba, Marco Antonio, Cattaneo, Marco, Moia, Marco, Bowers, Margaret, Chetanachan, Mariam, Berli, Mario Alberto, Fixley, Mark, Faghih, Markus, Stuecker, Markus, Schul, Marlin, Banyai, Martin, Koretzky, Martin, Myriam, Martin, Gaffney, Mary Elizabeth, Hirano, Masao, Kanemoto, Masashi, Nakamura, Mashio, Tahar, Mersel, Emmanuel, Messas, Kovacs, Michael, Leahy, Michael, Levy, Michael, Munch, Michael, Olsen, Michael, De Pauw, Michel, Gustin, Michel, Van Betsbrugge, Michiel, Boyarkin, Mikhail, Homza, Miroslav, Koto, Modise, Abdool‐Gaffar, Mohamed, Nagib, Mohamed Ayman Fakhry, El‐Dessoki, Mohamed, Khan, Mohamed, Mohamed, Monniaty, Kim, Moo Hyun, Lee, Moon‐Hee, Soliman, Mosaad, Ahmed, Mostafa Shawky, el Bary, Mostafa Soliman Abd, Moustafa, Moustafa A., Hameed, Muhammad, Kanko, Muhip, Majumder, Mujibur, Zubareva, Nadezhda, Mumoli, Nicola, Abdullah, Nik Azim Nik, Makruasi, Nisa, Paruk, Nishen, Kanitsap, Nonglak, Duda, Norberto, Nordin, Nordiana, Nyvad, Ole, Barbarash, Olga, Gurbuz, Orcun, Vilamajo, Oscar Gomez, Nandayapa Flores, Oscar, Gur, Ozcan, Oto, Oztekin, Javier Marchena, Pablo, Carroll, Patrick, Lang, Pavel, MacCallum, Peter, von Bilderling, Peter Baron, Blombery, Peter, Verhamme, Peter, Jansky, Petr, Bernadette, Peuch, De Vleeschauwer, Philippe, Hainaut, Philippe, Ferrini, Piera Maria, Iamsai, Piriyaporn, Christian, Ponchaux, Viboonjuntra, Pongtep, Rojnuckarin, Ponlapat, Ho, Prahlad, Mutirangura, Pramook, Wells, Rachel, Martinez, Rafael, Miranda, Raimundo Tirado, Kroening, Ralf, Ratsela, Rapule, Reyes, Raquel Lopez, Diaz de Leon, Raul Franco, Wong, Raymond Siu Ming, Alikhan, Raz, Jerwan‐Keim, Reinhold, Otero, Remedios, Murena‐Schmidt, Renate, Canevascini, Reto, Ferkl, Richard, White, Richard, Van Herreweghe, Rika, Santoro, Rita, Klamroth, Robert, Mendes, Robert, Prosecky, Robert, Cappelli, Roberto, Spacek, Rudolf, Singh, Rupesh, Griffin, Sam, Na, Sang Hoon, Chunilal, Sanjeev, Middeldorp, Saskia, Nakazawa, Satoshi, Toh, See Guan, Christophe, Seinturier, Isbir, Selim, Raymundo, Selma, Ting, Seng Kiat, Motte, Serge, Aktogu, Serir Ozkan, Donders, Servaas, Cha, Seung Ick, Nam, Seung‐Hyun, Marie‐Antoinette, Sevestre‐Pietri, Maasdorp, Shaun, Sun, Shenghua, Wang, Shenming, Essameldin, Sherif Mohamed, Sholkamy, Sherif Mohamed, Kuki, Shintaro, Yoshida, Shuichi, Matsuoka, Shunzo, McRae, Simon, Watt, Simon, Patanasing, Siriwimon, Jean‐Léopold, Siwe‐Nana, Wongkhantee, Somchai, Bang, Soo‐Mee, Testa, Sophie, Zemek, Stanislav, Behrens, Steffen, Dominique, Stephan, Mellor, Stuart, Singh, Suaran Singh Gurcharan, Datta, Sudip, Chayangsu, Sunee, Solymoss, Susan, Everington, Tamara, Abdel‐Azim, Tarek Ahmed Adel, Suwanban, Tawatchai, Adademir, Taylan, Hart, Terence, Béatrice, Terriat, Luvhengo, Thifhelimbilu, Horacek, Thomas, Zeller, Thomas, Boussy, Tim, Reynolds, Tim, Biss, Tina, Chao, Ting‐Hsing, Casabella, Tomas Smith, Onodera, Tomoya, Numbenjapon, Tontanai, Gerdes, Victor, Cech, Vladimir, Krasavin, Vladimir, Tolstikhin, Vladimir, Bax, W.A., Malek, Wagih Fawzy Abdel, Ho, Wai Khoon, Pharr, Walter, Jiang, Weihong, Lin, Wei‐Hsiang, Zhang, Weihua, Tseng, Wei‐Kung, Lai, Wen‐Ter, De Backer, Wilfried, Haverkamp, Wilhelm, Yoshida, Winston, Korte, Wolfgang, Choi, Won II, Kim, Yang‐Ki, Tanabe, Yasuhiro, Ohnuma, Yasushi, Mun, Yeung‐Chul, Balthazar, Yohan, Park, Yong, Shibata, Yoshisato, Burov, Yuriy, Subbotin, Yuriy, Coufal, Zdenek, Yang, Zhenwen, Jing, Zhicheng, and Yang, Zhongqi
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- 2019
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14. Stroke prevention, 1-year clinical outcomes and healthcare resource utilization in patients with atrial fibrillation in France: Data from the GARFIELD-AF registry
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Le Heuzey, Jean-Yves, Bassand, Jean-Pierre, Berneau, Jean-Baptiste, Cozzolino, Paolo, D’Angiolella, Lucia, Doucet, Bernard, Mantovani, Lorenzo G., Martelet, Michel, Mouallem, Joseph, Muller, Jean-Joseph, and Pieper, Karen
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- 2018
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15. Time-Trends in Air Pollution Impact on Health in Italy, 1990–2019: An Analysis From the Global Burden of Disease Study 2019
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Conti, Sara, primary, Fornari, Carla, additional, Ferrara, Pietro, additional, Antonazzo, Ippazio C., additional, Madotto, Fabiana, additional, Traini, Eugenio, additional, Levi, Miriam, additional, Cernigliaro, Achille, additional, Armocida, Benedetta, additional, Bragazzi, Nicola L., additional, Cadum, Ennio, additional, Carugno, Michele, additional, Crotti, Giacomo, additional, Deandrea, Silvia, additional, Cortesi, Paolo A., additional, Guido, Davide, additional, Iavicoli, Ivo, additional, Iavicoli, Sergio, additional, La Vecchia, Carlo, additional, Lauriola, Paolo, additional, Michelozzi, Paola, additional, Scondotto, Salvatore, additional, Stafoggia, Massimo, additional, Violante, Francesco S., additional, Abbafati, Cristiana, additional, Albano, Luciana, additional, Barone-Adesi, Francesco, additional, Biondi, Antonio, additional, Bosetti, Cristina, additional, Buonsenso, Danilo, additional, Carreras, Giulia, additional, Castelpietra, Giulio, additional, Catapano, Alberico, additional, Cattaruzza, Maria S., additional, Corso, Barbara, additional, Damiani, Giovanni, additional, Esposito, Francesco, additional, Gallus, Silvano, additional, Golinelli, Davide, additional, Hay, Simon I., additional, Isola, Gaetano, additional, Ledda, Caterina, additional, Mondello, Stefania, additional, Pedersini, Paolo, additional, Pensato, Umberto, additional, Perico, Norberto, additional, Remuzzi, Giuseppe, additional, Sanmarchi, Francesco, additional, Santoro, Rocco, additional, Simonetti, Biagio, additional, Unim, Brigid, additional, Vacante, Marco, additional, Veroux, Massimiliano, additional, Villafañe, Jorge H., additional, Monasta, Lorenzo, additional, and Mantovani, Lorenzo G., additional
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- 2023
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16. Early Risks of Death, Stroke/Systemic Embolism, and Major Bleeding in Patients With Newly Diagnosed Atrial Fibrillation: Results From the GARFIELD-AF Registry
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Bassand, Jean-Pierre, Virdone, Saverio, Goldhaber, Samuel Z., Camm, A. John, Fitzmaurice, David A., Fox, Keith A.A., Goto, Shinya, Haas, Sylvia, Hacke, Werner, Kayani, Gloria, Mantovani, Lorenzo G., Misselwitz, Frank, Pieper, Karen S., Turpie, Alexander G.G., van Eickels, Martin, Verheugt, Freek W.A., and Kakkar, Ajay K.
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- 2019
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17. Cost‐Effectiveness of the Early Arthritis Clinic Organizational Model
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Zanetti, Anna, primary, Sakellariou, Garifallia, additional, Zambon, Antonella, additional, Carrara, Greta, additional, Argnani, Lisa, additional, Mantovani, Lorenzo G., additional, Cortesi, Paolo A., additional, Bugatti, Serena, additional, Montecucco, Carlomaurizio, additional, and Scirè, Carlo A., additional
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- 2022
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18. Healthcare Resource Utilization in Patients with Newly Diagnosed Atrial Fibrillation: A Global Analysis from the GARFIELD-AF Registry
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Mantovani, Lorenzo G., Cozzolino, Paolo, Ferrara, Pietro, Virdone, Saverio, Camm, A. John, Verheugt, Freek W. A., Bassand, Jean-Pierre, Turpie, Alexander G. G., Hacke, Werner, Kayani, Gloria, Goldhaber, Samuel Z., Goto, Shinya, Pieper, Karen S., Gersh, Bernard J., Fox, Keith A. A., Haas, Sylvia, Eickels, Martin van, Kakkar, Ajay K., Investigators, on behalf of the GARFIELD-AF Investigators on behalf of the GARFIELD-AF, Mantovani, L, Cozzolino, P, Ferrara, P, Virdone, S, Camm, A, Verheugt, F, Bassand, J, Turpie, A, Hacke, W, Kayani, G, Goldhaber, S, Goto, S, Pieper, K, Gersh, B, Fox, K, Haas, S, van Eickels, M, and Kakkar, A
- Subjects
Health Information Management ,Leadership and Management ,Health Policy ,Health Informatics ,Article ,atrial fibrillation ,healthcare resource utilization ,inpatient care ,outpatient care ,ddc - Abstract
The management of atrial fibrillation (AF), the most common sustained arrhythmia, impacts healthcare resource utilization (HCRU). This study aims to estimate global resource use in AF patients, using the GARFIELD-AF registry. A prospective cohort study was conducted to characterize HCRU in AF patients enrolled in sequential cohorts from 2012 to 2016 in 35 countries. Components of HCRU studied were hospital admissions, outpatient care visits, and diagnostic and interventional procedures occurring during follow-up. AF-related HCRU was reported as the percentage of patients demonstrating at least one event and was quantified as rate-per-patient-per-year (PPPY) over time. A total of 49,574 patients was analyzed, having an overall median follow-up of 719 days. Almost all patients (99.5%) had at least one outpatient care visit, while hospital admissions were the second most frequent medical contact, with similar proportions in North America (37.5%) and Europe (37.2%), and slightly higher in the other GARFIELD-AF countries (42.0%; namely Australia, Egypt, and South Africa). Asia and Latin America showed lower percentages of hospitalizations, outpatient care visits, and diagnostic and interventional procedures. Analyses of GARFIELD-AF highlighted the vast AF-related HCRU, underlying significant geographical differences in the type, quantity, and frequency of AF-related HCRU. These differences were likely attributable to health service availability and differing models of care.
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- 2023
19. COSIMO – patients with active cancer changing to rivaroxaban for the treatment and prevention of recurrent venous thromboembolism: a non-interventional study
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Cohen, Alexander T., Maraveyas, Anthony, Beyer-Westendorf, Jan, Lee, Agnes Y. Y., Mantovani, Lorenzo G., Bach, Miriam, and on behalf of the COSIMO Investigators
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- 2018
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20. Benefits in pain perception, ability function and health-related quality of life in patients with failed back surgery syndrome undergoing spinal cord stimulation in a clinical practice setting
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Scalone, Luciana, Zucco, Furio, Lavano, Angelo, Costantini, Amedeo, De Rose, Marisa, Poli, Paolo, Fortini, Gianpaolo, Demartini, Laura, De Simone, Enrico, Menardo, Valentino, Meglio, Mario, Cozzolino, Paolo, Cortesi, Paolo A., and Mantovani, Lorenzo G.
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- 2018
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21. Italian Population-Based Values of EQ-5D Health States
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Scalone, Luciana, Cortesi, Paolo A., Ciampichini, Roberta, Belisari, Andrea, D’Angiolella, Lucia S., Cesana, Giancarlo, and Mantovani, Lorenzo G.
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- 2013
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22. Comparing the performance of the standard EQ-5D 3L with the new version EQ-5D 5L in patients with chronic hepatic diseases
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Scalone, Luciana, Ciampichini, Roberta, Fagiuoli, Stefano, Gardini, Ivan, Fusco, Francesco, Gaeta, Laura, Del Prete, Anna, Cesana, Giancarlo, and Mantovani, Lorenzo G.
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- 2013
23. Haemophilia management and treatment: An Italian survey on patients’, caregivers’ and clinicians’ point of view
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Cortesi, P, Rocino, A, Preti, D, Fragomeno, A, Cucuzza, F, Ceresi, N, Santoro, C, Ferretti, A, Fornari, A, Antonazzo, I, Facchetti, R, Cozzolino, P, Biasoli, C, Cassone, C, Coppola, A, Mantovani, L, Cortesi, Paolo Angelo, Rocino, Angiola, Preti, Daniele, Fragomeno, Anna, Cucuzza, Francesco, Ceresi, Nicola, Santoro, Cristina, Ferretti, Antonietta, Fornari, Arianna, Antonazzo, Ippazio Cosimo, Facchetti, Rita, Cozzolino, Paolo, Biasoli, Chiara, Cassone, Cristina, Coppola, Antonio, Mantovani, Lorenzo G., Cortesi, P, Rocino, A, Preti, D, Fragomeno, A, Cucuzza, F, Ceresi, N, Santoro, C, Ferretti, A, Fornari, A, Antonazzo, I, Facchetti, R, Cozzolino, P, Biasoli, C, Cassone, C, Coppola, A, Mantovani, L, Cortesi, Paolo Angelo, Rocino, Angiola, Preti, Daniele, Fragomeno, Anna, Cucuzza, Francesco, Ceresi, Nicola, Santoro, Cristina, Ferretti, Antonietta, Fornari, Arianna, Antonazzo, Ippazio Cosimo, Facchetti, Rita, Cozzolino, Paolo, Biasoli, Chiara, Cassone, Cristina, Coppola, Antonio, and Mantovani, Lorenzo G.
- Abstract
Introduction: Haemophilia management and patients’ quality of life significantly improved. However, data on current patients’, caregivers’ and clinicians’ satisfaction and limitations of treatments and haemophilia management are limited. Aim: Assessing the management satisfaction and unmet needs from the perspective of Italian patients with haemophilia (PWH) without inhibitors (or caregivers if children) and of specialist physicians. Methods: Surveys (for patients≥18 years, caregivers of children and haemophilia specialists) were developed by a multidisciplinary working group and conducted from November 2019 to June 2020. Results: Among 275 participants, 120 (43.6%) were PWH without inhibitors, 79 (28.7%) caregivers and 37 (13.4%) clinicians. Patients and caregivers perceived a higher control of the disease compared to clinicians. However, more than 40% of patients and caregivers reported to feel significantly conditioned by the risk of bleeding during their daily life. PWH reported a 6-month mean/median (range) of bleeds 2.3/.0 (0-24) and caregivers 1.3/.0 (0-16) in children. The treatment burden (frequency of administration) was not satisfactory for more than half adults and caregivers of children treated with prophylaxis. A good access to treatment, haemophilia centres and medical service was reported, with issues associated to the multidisciplinary approach and treatment at emergency department. Conclusions: This large national study provides an updated overview of haemophilia care in Italy from different points of views, highlighting positive aspects and unmet needs. This information can guide future interventions to improve haemophilia management and the assessment of impact of new treatment options.
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- 2022
24. Sacubitril/valsartan in heart failure with reduced ejection fraction: cost and effectiveness in the Italian context
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DʼAngiolella, Lucia S., Cortesi, Paolo A., Pitotti, Claudia, Ritrovato, Daniela, Mantovani, Lorenzo G., and Senni, Michele
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- 2017
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25. Editorial to Chuang et al
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Mantovani, Lorenzo G., primary
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- 2022
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26. Rivaroxaban compared with standard thromboprophylaxis after major orthopaedic surgery: co-medication interactions
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Kreutz, Reinhold, Haas, Sylvia, Holberg, Gerlind, Lassen, Michael R., Mantovani, Lorenzo G., Schmidt, André, and Turpie, Alexander G. G.
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- 2016
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27. Cost‐Effectivenessof the Early Arthritis Clinic Organizational Model
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Zanetti, Anna, Sakellariou, Garifallia, Zambon, Antonella, Carrara, Greta, Argnani, Lisa, Mantovani, Lorenzo G., Cortesi, Paolo A., Bugatti, Serena, Montecucco, Carlomaurizio, and Scirè, Carlo A.
- Abstract
Early diagnosis and tight control improve outcomes of rheumatoid arthritis (RA). However, whether establishing an early arthritis clinic (EAC) is sustainable for national health systems is not known. This analysis aimed to compare effectiveness and costs of an EAC compared to patients followed by the current standard of care. A retrospective study on administrative health databases of patients with a new diagnosis of RA was conducted: 430 patients followed in an EAC were enrolled, and 4 non‐EAC controls were randomly matched for each. During 2 years of follow‐up, the mean health care costs (outpatient, inpatient, pharmaceutical, and global) and 3 effectiveness measures (number and length of hospitalization and quality of care) of the EAC and non‐EAC were estimated. The incremental cost‐effectiveness ratio was calculated as well as the cost‐effectiveness acceptability curve. The cohorts included patients with a mean age of 55.4 years, and 1,506 patients (70%) were female. The mean pharmaceutical (2,602 versus 1,945 euros) and outpatient (2,447 versus 1,778 euros) costs were higher in the EAC cohort. Conversely, a higher rate of non‐EAC patients had a low adherence to quality‐of‐care indicators. The expected number of hospitalizations and the length of stay were statistically significantly higher in the non‐EAC versus EAC. Despite an expected increase in outpatient costs (visits and diagnostic tests) and pharmaceutical costs, the reduction in terms of number and length of hospitalizations and the higher adherence to international quality‐of‐care guidelines support the effectiveness of the EAC model.
- Published
- 2023
- Full Text
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28. Early Risks of Death, Stroke/Systemic Embolism, and Major Bleeding in Patients With Newly Diagnosed Atrial Fibrillation
- Author
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Voelkel-Babyesiza, R., Chen, D. D., Jaufeerally, F. R., Lee, Y. M., Lim, G., Lim, W. T., Thng, S., Yap, S. Y., Yeo, C., Oh, S., Pak, H. N., Kim, J-B, Kim, J. H., Jang, S-W, Kim, D. H., Ryu, D. R., Park, S. W., Kim, D-K, Choi, D. J., Oh, Y. S., Cho, M-C, Kim, S-H, Jeon, H-K, Shin, D-G, Park, J. S., Park, H. K., Han, S-J, Sung, J. H., Nam, G-B, On, Y. K., Lim, H. E., Kwak, J. J., Cha, T-J, Hong, T. J., Park, S. H., Yoon, J. H., Kim, N-H, Kim, K-S, Jung, B. C., Hwang, G-S, Kim, C-J, Worthy, V, Verdi, C., Tripti, T., Treasure, L., Thompson, N., Theobald, H., Thatcher, A., Stephanie, B., Smith, K., Shoemaker, J., Shaw, P., Sanghera, T., Sage, A., Robertson, C., Richardson, T., Richard, C., Raziano, S., Raynor, J., Purcell, T., Pickelsimer, N., Peterson, J., Pearl, G., Paserchia, S., Parrott, T., Parker, M., Palumbo, V, Orosco, C., Mooso, B., Minardo, J., Merritt, D., Malone, E., Lincoln, T., Lee, J. A., Lay, M., Langdon, J., Knowles, P., Kerr, J., Keeling, M., Karl, S., Jones, P., Jones, L., Jones, A., Jasinski, S., Hicks, T., Herrick, C., Henson, L., Headlee, M., Hawkins, B., Hartranft, E., Harbour, T., Hakimi, F., Haideri, A., Gentry, P., Fielder, D., Ferdinand, K., Felpel, S., Evans, L., Eley, M., Dickerson, A., DePauw, J., Congal, S., Cervellione, K., Cassidy, D., Canova, M., Cameron-Watts, J., Browne, A., Brown, A., Bowers, S., Bentley, M., Bartlett, M., Asafu-Adjaye, N., Treasure, C., Nishijima, D., Pitta, S., Duffy, P., Noveck, H., Ison, R., Alberts, M., Remmel, K., Theodoro, D., Diercks, D., Delafontaine, P., Ahmed, W., Reddy, R., Haque, I, Gutowski, T., Alfieri, A., Beach, S., Miller, S., Williams, M., Mendelson, R., Falkowski, S., Franco, M., Cox, M., Kutayli, W. M., Ferrick, K., Quick, A., Wilson, V, Mullen, P., Garcia, J., Blumberg, E., Rama, P., Canosa, R., Goldhaber, S. Z., Thanzeel, M., Sharma, R., Sharma, N., Mohamed, R., Maqsood, I, Makdad, M., Magdaluyo, K., Jadhav, S., Haridas, P., El Bardisy, S., Al Mulla, A., Abdul, A., Subbaraman, B., Khan, M., Gupta, R., Wassef, A., Bazargani, N., Maruthanayagam, R., Al Naeemi, A., Al Omairi, M., Abu-Mahfouz, M., Naguib, A., Singh, R., Esheiba, E. M., Ibrahim, M., Nathani, M., Agrawal, A., Yousef, G., Al Mahmeed, W., van Zyl, F., Tau, T., Tarr, G., Smith, L., Skein, A., Shaik, F., Sasto, J., Salie, M., Rikhotso, L., Page, A., Mostert, M., Mavhusa, L., Marks, J., Loyd, E., Karsten, M., Henley, L., Ellis, T., Du Plessis, G., de Meyer, L., Davids, A., Conway, G., Chami, C., Cassimjee, S., Cannon, C., Boshoff, C., Booysen, M., Bester, C., Angel, G., Oosthuysen, W., Maharajh, S., Ramdass, A., Engelbrecht, J., Ahmed, F., Ismail, S., Loghdey, R., Ueckermann, V, Mntla, P., Greyling, D., Louw, R., Murray, A., Theron, H., van Zyl, L., Guerra, M., Pillay, T., Garda, R., Kelfkens, Y., Horak, A., Siebert, H., Bayat, J., Kettles, D., Zaatout, E., Tawfik, M., Taha, N., Soliman, A., Sobhy, M., Setiha, M., Samir, S., Sami, N., Salem, H., Reda, M., Reda, A., Ohanissian, A., Nawar, M., Mowafy, A., Khairy, T., Katta, A., Elkhadem, M., El-Etreby, A., Elbahry, A., El Etriby, S., El Din, M. G., Abou Seif, S. K., Abd El-Aziz, A., Ragy, H., Wright, D., Wong, S., Trahey, T., Stevenson, J., Spearson, S., Snell, L., Schulman, S., Sas, G., Robinson, M., Roberts, P., Raines, M., Pinter, A., Petrie, F., Pandey, M., Otis, R., Otis, J., Neas, I, Navratil, J., Moor, R., Mangat, I, Lewis, S., Lewis, C., Largy, J., Kwan, L., Kornder, J., Korley, V, Kim, R., Kelly, S., Kahlon, R., Jethoo, G., Jean, C., Jackson, A. M., Hines, K., Hines, C., Haveman, K., Gulliver, W., Grenier, M-C, Fox, B., Fournier, D., Ferleyko, L., Fearon, A., Farquhar, D., Ewert, A., Dunnigan, J., Douglass, S., Dorian, P., Djaidani, Z., Denis, I, Dehghani, P., Daheb, S., Cleveland, T., Clarke, B., Carroll, L., Burke, E., Breakwell, L., Bignell, N., Bigcanoe, J., Bergeron, C., Beaudry, K., Aves, T., Aro, L., Ahmad, K., Bonet, J., Ramjattan, B., Cha, J., Lavoie, A., Parkash, R., Fikry, S., Vizel, S., MacDonald, P., Angaran, P., Coutu, B., Schweitzer, B., Hruczkowski, T., Dhillon, R., Dresser, G., Nadeau, R., Du Preez, M., Poirier, G., Heath, J., Berlingieri, J., Ayala-Paredes, F., Beaudry, P., Leader, R., Cheung, S., Pandey, A. S., Gupta, M., Luton, R., Eikelboom, J., Spyropoulos, A., Connolly, S. J., Wong, K., Wilford, E., Wallis, L., Waldman, A., Vorster, M., Tsay, I. M., Thompson, S., Tarrant, J., Swaraj, K., Sutcliffe, S., Stoyanov, N., Singleton, C., Singh, C., Shrestha, P., Shone, S., Setio, H., Seremetkoska, M., Sanders, L., Rose, J., Raynes, S., Ratcliffe, M., Rashad, H., Preston, S., Plotz, M., Paul, V, Patching, T., Patching, K., Parsons, L., Palmer, J., O'May, V, Oldfield, G., Nagalingam, V, Myers, J-D, Mussap, C., Morrison, H., McKeon, L., McIntosh, C., McCarthy, C., MacKenzie, M., Mackay, S., Leung, D., Lehman, S., Lehman, M., Lawlor, V, Kassam, I, Juergens, C., Johnson, K., Jacobson, B., Hoffmann, B., Hesketh, L., Hegde, M. P., Hayes, K., Modi, M. H., Grabek, T., Gibbs, J., Geraghty, R., Fitzpatrick, D., Fetahovic, T., Ferreira-Jardim, A., Eslick, R., Eskandari, M., Duroux, M., Dolman, M., Dixon, S., Dimitri, H., Cresp, D., Conway, B., Connelly, A., Carlton, L., Campo, M., Buckley, E., Boys, J., Bonner, M., Black, A., Beveridge, R., Batta, C., Barry, L., Aggarwala, A., Faunt, J., Carroll, P., Starmer, G., Rogers, J., Lee, A., Binnekamp, M., Jepson, N., Arstall, M., Astridge, P., Choi, A., O'Donnell, D., Crimmins, D., Blombery, P., Phan, T., Ayres, B., Zimmett, L., French, J., Eccleston, D., Kiat, H., Colquhoun, D., Catanchin, A., Coulshed, D., Kilian, J., Roberts-Thomson, P., Lehman, R., Abhayaratna, W., Van Gaal, W., Singh, B., Blenkhorn, A., Gibbs, H., Thomson, A., Thomas, N., Sword, A., Stoddart, H., Simper, H., Simmons, P., Shewring, J., Seamark, C., Saunders, P. B., Rogers, G., Rickenbach, M., Reed, R., Redpath, D., Randfield, S., Powell, K., Nadaph, M., Muvva, R., Munro, I, Lomax, L., Jeffers, L., Jacobs, P., Hay, A., Halpin, A., Goram, J., Fox, R., Flynn, A., Dooldeniya, C., Dobson, S., Cartwright, S., Bennett, J., Ayers, J., A'Court, C., Ahmad, S., Pugsley, M., Gunasegaram, J., Wong, M., Cooke, P., Beattie, A., McEleny, P., Wastling, R., McGinty, P., Bandrapalli, M., Liley, C., Vinson, P., Zaman, K., Davies, T., Forshaw, K., Veale, R., Wilkinson, J., Geatch, D., Estifano, S., Myhill, T., Lucraft, L., Batson, R., Choi, H., Stephenson, T., Hargreaves, N., Schatzberger, T., Davies, S., Baron, R. T., Haria-Shah, R., Bunney, R., Boon, M., Wong, T., Sterry, M., Shepherd, D., Walton, S., Jackson, D., Ward, B., Coates, S., Heer, A., Roberts, N., Coulson, W., Peters, S., Wilson, A., Khalaque, S., Choudhary, F., Sabir, A., Rothwell, A. C., Kim, D. B., Edwards, D., Braddick, M., Mannion, S., Aylward, M., Oliver, R., Hawkins, C., Galloway, S., Sharma, P., Heath, R., Danielsen, M., Neden, C. A., Stuart, E., Davies, R., Hart, N., Ali, A., Patel, J. R. A., Pinnock, H., Roome, P. C., Vercoe, S., Hodgins, I, Webster, J., Dau, H. S., Kamath, R., Lowe, S., Smith, R. N., Burns, G., Conn, P., Warke, A., Mulholland, C., Poland, K., McLeod, A. J., Glencross, S., Gibbons, L., Haq, I. U., Little, H., Barrow, S., Butter, K. C., Howard, M., Zaidi, S. M. A., Chigbo, C., Thompson, R., Walls, N., Hutton, C., Jacobs, M., Abushal, S., Davies, E., Oliver, J. L., Priyadharshan, R., Rogers, S., Milne, K., Parfitt, M., Wakeling, J., Alborough, E., Kelsall, A. R., Fooks, T., Fisher, E., Litchfield, J., Bisatt, J., Clark, M., Gray, D., Bird, N., Vishwanathan, B., Howitt, A., Strieder, E., Gilliland, A., de Kare-Silver, N., Sathananthan, S., Cairns, J., Willcock, W., Ahmad, N., Sarai, B., Watson, E., Thomas, M. J., Jones, K. P., Van Zon, G., Bradshaw, C., Cumberlidge, D. F., Douglas, K., Ladha, K., Saigol, M., Wong, S. W., Patel, R. P., Lumley, L., Murdoch, W., Kernick, D., Eden, J., Weeks, P., Jones, C. P., Ainsworth, P., Davies, J. A., Russell, D., Sinha, B., Railton, T., Gallagher, A., Pandya, P., Matthews, J., Wadeson, P., Thurston, S., West, R., Stipp, Y., Macey, N., Scouller, F., Evans, P., Lumb, W., Wetherwell, S., Aldegather, J., Oginni, O., Giles, C., Jones, H., Sharp, H., Jefferies, A., Richardson, M., Paul, C., Seamark, D., Tragen, D., Taylor, G., St Joseph, V, Thompson, J., Fairhead, S., Franklin, S., Wilson, P., Ramesh, C., Aziz, M., Paul, N., Stokes, M., Wakeman, A., Hutchinson, P., Bilas, R., Sircar, S., Singal, A., Suryani, S., Wagner, H., Gooding, T., Williams, A., McDonnell, J., Pickavance, G., Kainth, M. S., Ross, A., Jhittay, P. S., Leese, J., Evans, R., Saunders, P., Goodwin, D., Chauhan, N., Fitzmaurice, D., Varenov, V., Todoriuk, L., Stets, R., Shumakov, O., Sapatyi, A., Romanova, O., Romanenko, O., Rasputina, L., Pyvovar, S., Proshak, O., Plevak, D., Petrovskyy, R., Pavelko, M., Palamarchuk, O., Ovdiienko, T., Nemtsova, V, Mospan, M., Mochonyi, V, Medentseva, O., Matova, O., Kizim, S., Khyzhnyak, O., Kaplan, P., Kamenska, E., Ivanov, A., Daniuk, I, Chabanna, O., Burdeuna, L., Berko, G., Belegai, R., Fushtey, I, Tykhonova, S., Yagensky, A., Kraydashenko, O., Stanislavchuk, M., Sychov, O., Svyshchenko, Y., Kovalskyi, I, Koval, O., Ushakov, O., Mostovoy, Y., Serediuk, N., Kupnovytska, I, Kraiz, I, Zhurba, S., Karpenko, O., Tseluyko, V, Rudyk, I, Parkhomenko, A., Winnik, S., Saga, E., Henriette, I, Guinand, A., Grau, A., Elise, G., Bruegger, J., Amstutz, D., Debrunner, J., Beer, J. H., Steffel, J., Thorsen, C., Stjernberg, M., Skoglund, K., Shayesteh, M., Samuelsson, J., Rosenberg, K., Risbecker, K., Pedersen, A., Osberg, A., Olofsson, A., Ohlin, A-M, Nilsson, C., Millborg, M., Mansson, K., Mannermyr, A., Lindholm, C-J, Lindberg, A., Lettenstrom, A., Kusiak, D., Koch, A., Kangert, R-M, Jansson, J-H, Jansson, B., Jaensson, P., Hahn, S., Grassjo, C., Floren, K., Eriksson, G-B, Ekstrand, A-B, Dzeletovic, S., Bonkowski, G., Al-Khalili, F., Ahlmark, H., Ahbeck, E., Aaroe, H., Stalby, P., Hot-Bjelac, A., Thulin, J., Engdahl, J., Bernsten, F., Martinsson, B., Malmqvist, L., Andersson, A., Jensen, S. A., Karlsson, J-E, Crisby, M., Romberg, K., Timberg, I, Eriksson, B., Platonov, P., Handel, H., Thorne, K., Svensson, P., Lindvall, H., Ohlsson, A., Ericsson, M., Kadir, K., Hajimirsadeghi, A., Bothin, C., Benson, L., Andersson, L. (Lisbeth), Andersson, L. (Lars), Gustavsson, M., Olsson, L-B, Lindh, A., Liu, B., Svard, G., Borjesson, U., Egilsson, A., Elmersson, M., Henriksson, K., Linden, J., Wirdby, A., Rosenqvist, M., Ubeda Pastor, M., Torres Marques, J., Torres, C., Tobajas, G., Terns Riera, M., Teixido Fontanillas, M., Sorribes Lopez, J., Simon Valero, C., Sierra, N., Serralvo, E., Seoane Blanco, A., Senan Sanz, M. R., Santolaya, C., Sanchez Parra, S., Sanchez Mendez, L., Sanchez Calderon, P., Saez Jimenez, S., Rodriguez Garcia, M., Rodriguez, E., Rodrigo, C., Roca Saumell, C., Roca, M., Robiro Robiro, X., Rivera, R., Riquelme Sola, L., Rios, V, Rincon Diaz, L. M., Quintern, V, Prieto, I, Perez Carasa, M., Pereda Armayor, M., Pena Garcia, E., Pareja Ibar, I., Palomo Merchan, N., Otero Tomera, D., Ortiz Cortes, C., Ortega, V. M., Orellana Figueroa, H. N., Negrete Palma, A., Munoz Munoz, R. B., Moure Gonzalez, M., Montes, D., Montero Alia, P., Molina, M., Millan, G., Mendez Zurita, F., Mazon, P., Martinez Mena, M., Martin Vila, A., Marcus, S., Mara Guerra, J., Manzanal Rey, A., Lopez, M., Llobet Molina, M., Lezcano Gort, L. E., Lasuncion, I, Lage Bouzamayor, M. B., Juan Salvadores, P., Jimenez Fernandez, M. J., Iglesias Garcia, A., Hevia Rodriguez, E., Herrero Maeso, B., Gutierrez del Val, M. del C., Guerrero Molina, A., Grigorian, L., Gonzalez, P., Gonzales Segovia, A., Gomez Perez, Y., Gomez, C., Gines Garcia, C., Gavira Saenz, M., Garcia Millan, V, Garcia Bermudez, M., Fosch, J., Ferrer, A., Fernandez Mas, E., Fernandez Escobar, E., Fernandez, M., Espallargas, A., Elorriaga Madariaga, A., Domenech Borras, A., Diaz Lopez, C. M., Dachs, M., Cotilla Marco, M., Costas, S., Prego de Faria, J. Costa Pinto, Cortada Cabrera, A., Codinachs Alsina, R., Cebollada del Misterio, M., Castro Fernandez, D., Ahn, J. J., Chow, J. H., Foo, C. G., Ching, C. K., Lim, T. W., Yoshida, K., Yokoyama, Y., Yasui, K., Yamazoe, M., Yamaura, M., Yamamoto, T., Yamamoto, K. (Kunihiko), Yamamoto, K. (Kentaro), Yamamoto, K. (Kenichi), Yamaguchi, H., Yamagishi, T., Yamada, T., Watanabe, M., Washizuka, T., Wakiyama, T., Wakaki, N., Ueyama, Y., Ueda, O., Uchiyama, H., Tsuzaki, K., Tsuji, T., Tsuchiya, Y., Toru, S., Tohyo, S., Teragawa, H., Taya, K., Tanabe, G., Tana, T., Takenaka, K., Takei, K., Takeda, H., Take, S., Takanaka, C., Takai, H., Takahashi, S., Takahashi, K., Takagi, Y., Takagi, T., Taguchi, A., Tada, M., Suzuki, Y., Suzuki, S. (Susumu), Suzuki, S. (Shunji), Suzuki, S. (Shu), Suzuki, K. (Keita), Suzuki, K. (Kazuo), Sugimoto, C., Suga, T., Shozawa, Y., Shiraiwa, T., Shirai, T., Shinozuka, T., Shinohe, R., Shinohara, H., Shindo, T., Shimoyama, Y., Shimono, H., Shiina, Y., Shibata, N., Sezaki, K., Seta, Y., Sekine, Y., Seki, S., Sawano, M., Sato, K. (Kiyoharu), Sato, K. (Kazuki), Sasaki, T., Sasaki, A., Sasaguri, H., Sasagawa, Y., Samejima, Y., Sakamoto, Y., Sakamoto, N., Sakai, H., Saito, Y., Otaki, E., Ota, A., Oriso, S., Pearce, Y. Onuki, Ono, T., Ono, H., Okuyama, M., Okita, H., Okamoto, K., Okada, M., Ohara, N., Ogawa, T., Nozoe, M., Nomura, S., Nomura, K., Niwa, I, Nishizawa, K., Nishioka, H., Nishino, K., Nishihata, Y., Nishida, Y., Niinuma, H., Niijima, Y., Nariyama, J., Nanke, T., Nakazato, R., Nakayama, T., Nakanishi, N., Nakamura, R., Nakamura, M., Nakahara, S., Nakagomi, A., Nagata, H., Nagata, E., Nagai, S. (Shunichi), Nagai, S. (Sho), Murai, O., Morishita, K., Moriai, O., Mori, T., Mizuno, A., Mizuguchi, I, Miyata, S., Miyashita, A., Miyamoto, H., Miyajima, S., Miyaguchi, S., Miura, N., Mitsuhashi, H., Mineoi, K., Matsuura, Y., Matsushita, K., Matsui, S., Maruyama, Y., Maeda, K., Maeda, I, Kumazaki, T., Kumai, Y., Kozuka, T., Kotani, T., Koshibu, Y., Komatsu, I, Komatsu, H., Kojima, J., Koeda, T., Kobayashi, T., Kito, T., Kitazumi, H., Kitazawa, H., Kira, T., Kim, J., Kawano, S., Kawamoto, T., Kawakami, S., Kawakami, K., Kawai, K., Kawada, Y., Kato, Y., Kato, T., Kasai, T., Kano, H., Kaneko, M., Kanda, H., Kanai, H., Kamata, J., Kakuda, H., Iwase, T., Ito, N., Ishioka, N., Ishihara, A., Iseki, F., Inoue, T., Inaba, H., Imaizumi, M., Ikeoka, K., Ikeda, K., Ikeda, H., Iiji, O., Ido, T., Horie, H. (Hideki), Honda, M., Hirota, S., Hirose, M., Hirayama, H., Hirasawa, K., Higuchi, K., Hayashi, Y., Hatsuno, T., Hasegawa, K., Hanazono, N., Hamaoka, M., Goto, T., Furumoto, W., Furukawa, T., Furukawa, N., Fukui, T., Fukuda, T., Fujisawa, Y., Fujisawa, A., Fujiki, R., Fujii, Y., Endo, M., Emura, Y., Doiuchi, J., Date, H., Chibana, H., Betsuyaku, T., Baba, T., Azuma, J., Asano, T., Asano, H., Arino, T., Arima, S., Arai, H., Aoyama, T., Aoki, K., Amano, T., Akahane, K., Adachi, T., Adachi, S. (Susumu), Adachi, S. (Sen), Abe, Y., Nagasaka, S., Okuda, F., Mukawa, H., Wada, M., Minagawa, T., Ishiguro, M., Mizuguchi, M., Yoshida, T. (Tomoki), Yoshida, T. (Tetsuro), Neya, K., Soma, A., Shiga, Y. (Yukio), Sugishita, N., Horie, H. 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(Hiroyuki), Ageta, M., Oyama, R., Nakamura, Y. (Yoichi), Kitami, Y., Hatori, Y., Takeuchi, M., Tsuchida, K., Iwao, T., Yokota, N., Hoshino, F., Takamura, I, Akutsu, M., Shimoyama, M., Ogurusu, C., Murata, K., Nakatsuka, M., Ishizawa, M., Fujiura, Y. (Yoshitake), Ikeda, D., Yoshida, H., Eto, T., Gushiken, M., Higa, S., Kuwahata, T., Oba, I, Tachibana, H., Obunai, K., Fudo, T., Saito, K. (Kazuyuki), Saito, K. (Katsumi), Tsunoda, S., Kihara, H., Abe, S., Maekawa, H., Yamasawa, M., Wakasa, Y., Murakami, K., Kamogawa, Y., Tatematsu, H., Ogawa, J., Numata, H., Yoshimura, A., Fujiura, Y. (Yoshihisa), Zaitsu, R., Nandate, H., Nakamura, T. (Tsugihiro), Nakamura, T. (Tadashi), Kato, H., Miyagi, H., Suefuji, H., Haraguchi, Y., Minoda, K., Goto, K., Sonoda, R., Oba, Y., Murayama, T., Kumeda, K., Komaki, S., Azakami, S., Okada, K., Higashi, T., Ando, H., Koyanagi, T., Tsuruta, M., Norita, H., Chiba, K., Adachi, S., Shiraishi, K., Oda, H. 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Hoegh, Oien, T., Christersson, P., Kolodzinska, A., Kirchner-Volker, K., Svilaas, A., Klein, V, Kroll, D., Ghezai, B., Krueger, A., Lehmann, R., Mann, L., Maselli, A., Menken, G., Mikes, K., Mortan, H., Nasser, N., Nicolaus, D., Plauskat, A., Pomper, L., Quietzsch, A., Ravenhorst, C., Komlo, A., Konopka, A., Korczowska, E., Kowal, E., Kowalczyk, H. K., Kremis, E., Kruczyk, D., Krzesiak-Lodyga, A., Krzyzanowski, M., Kurdzielewicz, W., Kustrzycka-Kratochwil, D., Lesniewska-Krynska, D., Leszczynski, J., Lewicka, E., Lichota, E., Lip, K., Loboz-Rudnicka, M., Luka, J., Volodicheva, O., Zemlianskaia, O., Zhirov, I, Lysek-Jozefowicz, A., Machnikowska, M., Majewska, K., Mariankowski, R., Ostrem, A., Skjelvan, G., Hallaraker, A., Markiewicz, A., Erga, K., Hole, T., Gjertsen, E., Sirnes, P. A., Mazur, M., Metzgier-Gumiela, A., Berge, E., Atar, D., Westerman, L., van Putten, J. J., van Leeuwen, G., van der Kley, T., Miedlar, E., van de Loo, R., Mielcarek, M., Neubauer-Geryk, J., Monako, G., Medvedeva, T., Machilskaya, O., Lileeva, E., Lebedeva, O., Niedek, J., Niemirycz-Makurat, A., Kuvanova, M., Kurylo, B., Kupriyanova, T., Kungurtseva, O., Kuchuk, P., Kropova, O., Nowak, A., Nowak, S., Zhuravleva, E., Zotova, I, Korneeva, O., Konyushenko, D., Vinolas, X., Alvarez Garcia, P., Kolesova, T., Ivanova, Y., Lopez Fernandez, M. F., Gurmach, M., Tercedor, L., Gubanov, A., Tranche Iparraguirre, S., Toran Monserrat, P., Marquez Contreras, E., Isart Rafecas, J., Motero Carrasco, J., Gorshkova, T., Opielowska-Nowak, B., Garcia Pavia, P., Gomez Pajuelo, C., Moro Serrano, C., Gorbunova, E., Iglesias Alonso, L. F., Erofeeva, S., Grande Ruiz, A., Ozgowicz, M., Pawelska-Buczen, A., Merce Klein, J., Gonzalez Juanatey, J. R., Baron Esquivias, G., Monte Collado, I, Palacin Piquero, H., Brotons Cuixart, C., Rodriguez Morato, M., Llibre, J. Bayo, Corros Vicente, C., Vida Gutierrez, M., Epelde Gonzalo, F., Almeida Fernandez, C. A., Del Val Plana, N., Escriva Montserrat, E., Montero Alia, J. J., Barreda Gonzalez, M., Moleiro Oliva, M. A., Iglesias Sanmartin, J., Jimenez Gonzalez, M., Dumikyan, A., Rodriguez Alvarez, M., Herreros Melenchon, J., Ripoll Vera, T., Ridocci Soriano, F., Garcia Riesco, L., Marco Macian, M. D., Quiles Granado, J., Jimenez Navarro, M., Cosin Sales, J., Vaquer Perez, J. V., Pawlik-Rak, E., Chugunnaya, S., Vazquez Caamano, M., Arcocha Torres, M. F., Marcos Gomez, G., Iniguez Romo, A., Prieto Diaz, M. A., Bitakova, F., Alonso, C. (Carmela), Alonso, C. (Concepcion), Alvarez, D., Alvarez, M., Belenkova, Y., Amaro, M., Andere, N., Aracil Villar, J., Batalov, R., Armitano Ochoa, R., Austria, A., Agakhanyan, A., Barbeira, S., Barraquer Feu, E., Uppelschoten, B., Reichelt, C., Piotrowicz, R., Tonino, P., Reimer, C., Schaefer, B., Scharrer, S., Schirmer, K., Schmidt, K., Schoene, R., Schulze, J., Schuppe, M., Simon, S., Sommer, S., Spranger, K., Talkenberger, A., Tauber, K., Tetlak, A., Toennishoff, T., Bartes, A., Voigts, B., Weiser, U., Wesendorf, S., Wildenauer, S., Wolf, T., Wurziger, J., Zak, J., Zauzig, H-D, te Kaat, J., Ziefle, S., Zincke, S., Keltai, M., Vangel, S., Szalai, G., Merkely, B., Kancz, S., Boda, Z., Nagy, A., Laszlo, Z., Matoltsy, A., Gaszner, B., Polgar, P., Habon, T., Noori, E., Juhasz, G., Kanakaridisz, N., Szentpeteri, I, Juhasz, F., Vertes, A., Papp, A., May, Z., Stallinga-de Vos, A., Ferenczi, J., Egyutt, M., Engelthaler, G., Fulop, E., Gombos, P., Gulyas, D., Jen, P., Edin, A., Becerra Munoz, V, Gyorke, E. Kiralyhazine, Kovacs, M., Levang, S. Kovacsne, Marianna, S., Radics, Z., Bermudez Jimenez, F. J., Branjovich Tijuan, A., Cabeza Ramirez, J., Cabrera Ramos, M., Calvo Martinez, E., Campo Moreno, M., Cancho Corchado, G., Casanova Gil, M., Castillo Orive, M., Pronk, A., Ptaszynski, P., Raczynska, A., Rogowski, W., Mulder, R., Melman, P., Romanek, J., Romaszkiewicz, R., Krikken, J., Rostoff, P., Roszczyk, N., Rozewska-Furmanek, D., Rychta, J., Koomen, E. M., Rzyczkowska, B., Sidor, A., Skalska, J., Smichura, M., Splawski, M., Staneta, P., Staniszewska, E., Starak-Marciniak, J., Stopyra-Poczatek, M., Sukiennik-Kujawa, M., Szafranski, J., Szalecki, P., Szczepanska, A., Szkrobka, W., Szuchnik, E., Szulowska, A., Kloosterman, T., Kelderman, M., Szumczyk-Muszytowska, G., Szwoch, M., Jetten, W., Traczyk, T., Troszczynska, M., Trzcinski, G., Tybura, S., Walasik, P., Wegrzynowska, M., Wesolowska, K., Wieczorek, W., Wierzbicka, A., Wilczewski, P., Wilgat-Szecowka, M., Wojewoda, P., Wojnowski, L., Wrobel, M., Zakutynska-Kowalczyk, K., Zyczynska-Szmon, M., Panchenko, E., Eltishcheva, V, Libis, R., Tereshchenko, S., Popov, S., Kamalov, G., Belenky, D., Zateyshchikova, A., Kropacheva, E., Kolesnikova, A., Nikolaev, K., Egorova, L., Khokhlov, A., Yakupov, E., Poltavskaya, M., Zateyshchikov, D., Drapkina, O., Vishnevsky, A., Barbarash, O., Miller, O., Aleksandrova, E., Chizhov, P., Sydo, N., Szalo, R., Szilagyi, A., Sergeev, M., Sztanyik, F., Shutemova, E., Vandrus, B., Agnelli, G., Mazur, E., Ambrosio, G., Tiraferri, E., Santoro, R., Testa, S., Di Minno, G., Moia, M., Caimi, T. M., Martini, G., Tessitori, M., Cappelli, R., Poli, D., Quintavalla, R., Melone, F., Cosmi, F., Pizzini, A., Piseddu, G., Fanelli, R., Latella, C., Santi, R., Pancaldi, L., De Cristofaro, R., Palareti, G., De Blasio, A., Zrazhevskiy, K., Novikova, T., Kostenko, V, Moiseeva, Y., Polkanova, E., Uriarte, J. Salerno, Minetti, F., Pogliani, E. M., Lonati, L. M., Accogli, M., Ciampani, N., Malengo, S., Feola, M., Raisaro, A., Fattore, L., Grilli, P., Germini, F., Settimi, M., Alunni, M., Sobolev, K., Rossovskaya, M., Duranti, G., Tedeschi, L., Zubeeva, G., Shapovalova, Y., Baglioni, G., Avanzino, G., Berardi, M., Pannacci, V, Giombolini, A., Nicoli, S., Scarponi, T., Allasia, B., Ricciarini, P., Nasorri, R., Argena, A., Bossolasco, P., Ronchini, P., Filippi, A., Tradati, F., Bulla, C., Donzelli, L., Foppa, L., Bottarelli, M. L., Tomasello, A., Mauric, A., Femiano, C., Reggio, R., Lillo, F., Mariani, A., Forcignano, F., Volpe, M., D'Avino, M., Yildirim, E., Yildirim, R., Bongiorni, M. G., Severi, S., Capucci, A., Lodigiani, C., Salomone, E., Serviddio, G., Tondo, C., Golino, P., Mazzone, C., Iacopino, S., Pengo, V, Galvani, M., Moretti, L., Ambrosino, P., Banfi, E., Biagioli, V, Bianchi, A., Boggian, G., Breschi, M., Brusorio, S., Ball, K., Calcagnoli, F., Campagna, G., Page, M., Renom, R., Jimeno Besa, B., Carpenedo, M., Ciabatta, C., Ciliberti, G., Kis, E., Cimmino, G., Ramos Gonzalez, M., Vieira Torres, L. G., Sucu, M., Chattranukulchai, P., Cho, J-G, D'Arienzo, C., Di Gennaro, L., Fedele, M., Ferrini, P. M., Jerzewski, A., Gorrebeeck, K., Geerlings, F., Dols, S., Debordes, M., de Graauw, J., De Graaf, J., Granzow, K., Danse, I, Bruin, S., Bosschaert, M., Bosman, F., Boersma-Slootweg, M., Boersma, L. V. A., Buiks, C., Terpstra, W., Groenemeijer, B. E., Nagibovich, O., Hermans, W., Guazzaloca, G., Hoogslag, P. A. M., Nierop, P. R., Guerra, F., The, S. H. K., Adriaansen, H., Lucassen, A., Lochorn, G., Herrman, J-P, Guldener, C., Pieterse, M. G. C., Bongaerts, M., Klomps, H., Ruiter, J. H., ten Cate, H., Zecca, C., Villani, R., Sottilota, G., Segreti, L., Scarone, C., Scaccianoce, A., Salomone, L., Rangel, G., Oriana, V, Occhilupo, P., Poeta, E. Mollica, Mesolella, E., Macellari, F., Longo, S., Lo Buglio, A., Tao, G. Z., Rosenqvist, Marten, Kasala, L., Oto, Ali, He, X. A., Zhou, B., Vinolas, Xavier, Kakkar, Ajay K., Fitzmaurice, David A., Fox, Keith A. A., Kayani, Gloria, Virdone, Saverio, Camm, A. John, and Pieper, Karen S.
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medicine.medical_specialty ,business.industry ,Systemic embolism ,Atrial fibrillation ,Newly diagnosed ,Meth ,ta3121 ,medicine.disease ,chemistry.chemical_compound ,chemistry ,Physiology (medical) ,Internal medicine ,Antithrombotic ,Cardiology ,Medicine ,In patient ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Stroke ,Major bleeding - Abstract
Background: Atrial fibrillation is associated with increased risks of death, stroke/systemic embolism, and bleeding (incurred by antithrombotic therapy), which may occur early after diagnosis. Methods: We assessed the risk of early events (death, stroke/systemic embolism, and major bleeding) over 12 months and their relation to the time after diagnosis of atrial fibrillation in 52 014 patients prospectively enrolled in the GARFIELD-AF registry (Global Anticoagulant Registry in the FIELD–Atrial Fibrillation) between March 2010 and August 2016. Results: Over 12 months, 2140 patients died (mortality rate, 4.3; 95% CI, 4.2–4.5 per 100 person-years), of whom 288 (13.5%) died in the first month (6.8; 95% CI, 6.1–7.6). Over 12 months, 657 patients had a stroke/systemic embolism (1.3; 95% CI, 1.2–1.4) and 411 had a major bleeding (0.8; 95% CI, 0.8–0.9). During the first month, the rates (per 100 person-years) of stroke/systemic embolism and major bleed were 2.3 (95% CI, 1.9–2.8) and 1.5 (95% CI, 1.2–1.9), respectively. The elevated 1-month mortality rate was mostly attributable to cardiovascular mortality (3.5; 95% CI, 3.0–4.1), in particular, heart failure, sudden death, and acute coronary syndromes (1.0 [95% CI, 0.8–1.4], 0.6 [95% CI, 0.4–0.8], and 0.5 [95% CI, 0.3–0.8], respectively). Age, heart failure, prior stroke, history of cirrhosis, vascular disease, moderate-to-severe kidney disease, diabetes mellitus, and living in North or Latin America were independent predictors of a higher risk of early death, whereas anticoagulation and living in Europe or Asia were independent predictors of a lower risk of early death. A predictive model developed for the 1-month risk of death had a C-statistic of 0.81 (95% CI, 0.78–0.83). Conclusions: The increased hazard of early events, in particular, cardiovascular mortality, in newly diagnosed atrial fibrillation points to the importance of comprehensive care for such patients and should alert clinicians to detect warning signs of possible early mortality. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01090362.
- Published
- 2019
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29. Risk Profile and 1-Year Outcome of Newly Diagnosed Atrial Fibrillation in Japan ― Insights From GARFIELD-AF ―
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Kolesova, T., Yilmaz, MEHMET BİRHAN, Kakkar, Ajay K., Allu, Jagan, Worthy, V., Verdi, C., Tripti, T., Treasure, L., Thompson, N., Theobald, H., Thatcher, A., Stephanie, B., Smith, K., Shoemaker, J., Shaw, P., Sanghera, T., Sage, A., Robertson, C., Richardson, T., Richard, C., Raziano, S., Raynor, J., Minardo, J., Merritt, D., Merliss, A., Malone, E., Lincoln, T., Lee, J. A., Lay, M., Langdon, J., Knowles, P., Kerr, J., Keeling, M., Karl, S., Jones, P., Jones, L., Jones, A., Johnson, K., Jasinski, S., Hicks, T., Herrick, C., Henson, L., Headlee, M., Hawkins, B., Hartranft, E., Harbour, T., Hakimi, F., Haideri, A., Gentry, P., Fielder, D., Ferdinand, K., Felpel, S., Evans, L., Eley, M., Dickerson, A., DePauw, J., Congal, S., Cervellione, K., Cassidy, D., Canova, M., Browne, A., Brown, A., Bowers, S., Bentley, M., Bartlett, M., Ball, K., Asafu-Adjaye, N., Treasure, C., Nishijima, D., Pitta, S., Duffy, P., Noveck, H., Ison, R., Alberts, M., Remmel, K., Theodoro, D., Diercks, D., Delafontaine, P., Ahmed, W., Reddy, R., Haque, I., Gutowski, T., Alfieri, A., Sharma, N., Beach, S., Miller, S., Williams, M., Mendelson, R., Falkowski, S., Franco, M., Cox, M., Kutayli, W. M., Ferrick, K., Quick, A., Wilson, V., Mullen, P., Garcia, J., Blumberg, E., Rama, P., Canosa, R., Goldhaber, S. Z., Thanzeel, M., Sharma, R., Mohamed, R., Maqsood, I., Makdad, M., Magdaluyo, K., Jadhav, S., Haridas, P., El Bardisy, S., Al Mulla, A., Abdul, A., Subbaraman, B., Khan, M., Gupta, R., Wassef, A., Bazargani, N., Maruthanayagam, R., Al Naeemi, A., Al Omairi, M., Naguib, A., Singh, R., Esheiba, E. M., Ibrahim, M., Nathani, M., Agrawal, A., Yousef, G., Al Mahmeed, W., van Zyl, F., Tau, T., Tarr, G., Smith, L., Skein, A., Shaik, F., Sasto, J., Salie, M., Rikhotso, L., Page, A., Mostert, M., Mavhusa, L., Marks, J., Loyd, E., Karsten, M., Henley, L., Ellis, T., Du Plessis, G., de Meyer, L., Davids, A., Conway, G., Chami, C., Cassimjee, S., Cannon, C., Boshoff, C., Booysen, M., Bester, C., Angel, G., Oosthuysen, W., Maharajh, S., Ramdass, A., Engelbrecht, J., Ahmed, F., Ismail, S., Loghdey, R., Ueckermann, V., Mntla, P., Greyling, D., Louw, R., Murray, A., Theron, H., van Zyl, L., Guerra, M., Pillay, T., Garda, R., Kelfkens, Y., Horak, A., Hines, C., Haveman, K., Gulliver, W., Grenier, M. -C., Fox, B., Fournier, D., Ferleyko, L., Fearon, A., Farquhar, D., Ewert, A., Dunnigan, J., Douglass, S., Djaidani, Z., Denis, I., Dehghani, P., Daheb, S., Cleveland, T., Clarke, B., Carroll, L., Burke, E., Breakwell, L., Bignell, N., Bigcanoe, J., Bergeron, C., Beaudry, K., Aves, T., Aro, L., Angaran, P., Ahmad, K., Bonet, J., Ramjattan, B., Cha, J., Lavoie, A., Parkash, R., Fikry, S., Vizel, S., MacDonald, P., Coutu, B., Schweitzer, B., Hruczkowski, T., Dhillon, R., Dresser, G., Nadeau, R., Du Preez, M., Poirier, G., Heath, J., Purcell, T., Pickelsimer, N., Peterson, J., Pearl, G., Paserchia, S., Parrott, T., Parker, M., Palumbo, V., Orosco, C., Mooso, B., Berlingieri, J., Ayala-Paredes, F., Beaudry, P., Leader, R., Cheung, S., Pandey, A. 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(Sho), Murai, O., Morishita, K., Moriai, O., Mori, T., Mizuno, A., Mizuguchi, I., Miyata, S., Miyashita, A., Miyamoto, H., Miyajima, S., Miyaguchi, S., Miura, N., Mitsuhashi, H., Mineoi, K., Matsuura, Y., Matsushita, K., Matsui, S., Maruyama, Y., Maeda, K., Maeda, I., Kumazaki, T., Kumai, Y., Kozuka, T., Kotani, T., Koshibu, Y., Komatsu, I., Komatsu, H., Kojima, J., Koeda, T., Kobayashi, T., Kito, T., Kitazumi, H., Kitazawa, H., Kira, T., Kawano, S., Kawamoto, T., Kawakami, S., Kawakami, K., Kawai, K., Kawada, Y., Kato, Y., Kato, T., Kasai, T., Kano, H., Kaneko, M., Kanda, H., Kanai, H., Kamata, J., Kakuda, H., Iwase, T., Ito, N., Inoue, T., Inaba, H., Imaizumi, M., Ikeoka, K., Ikeda, K., Ikeda, H., Iiji, O., Ido, T., Horie, H. (Hideki), Honda, M., Hirota, S., Hirose, M., Hirayama, H., Hirasawa, K., Higuchi, K., Hayashi, Y., Hatsuno, T., Hasegawa, K., Hanazono, N., Hamaoka, M., Goto, T., Furumoto, W., Furukawa, T., Furukawa, N., Fukui, T., Fukuda, T., Fujisawa, Y., Fujisawa, A., Fujii, Y., Endo, M., Emura, Y., Doiuchi, J., Betsuyaku, T., Baba, T., Azuma, J., Asano, T., Asano, H., Arino, T., Aoyama, T., Aoki, K., Amano, T., Akahane, K., Adachi, T., Adachi, S. (Susumu), Adachi, S. (Sen), Abe, Y., Nagasaka, S., Okuda, F., Mukawa, H., Wada, M., Minagawa, T., Ishiguro, M., Mizuguchi, M., Yoshida, T. (Tomoki), Fujiura, Y., Kawano, Y., Abe, M., Mizuno, Y., Kanamori, S., Mori, E., Shirakawa, K., Ishioka, N., Noguchi, H., Nobuhito, Y., Shiga, Y., Toyota, F., Nakamura, T., Nakamura, Y., Okamoto, Y., Miyoshi, H., Shinohara, H., Shigekiyo, M., Miyamoto, Y., Ota, A., Okada, M., Yoshida, T., Iseki, F., Katsuya, T., Shindo, T., Suzuki, S., Shiraiwa, T., Ono, T., Otaki, E., Sato, K., Saito, K., Suzuki, K., Kodera, K., Pearce, Onuki Y., Sezaki, K., Ubukata, S., Honzawa, T., Sasaki, T., Seta, Y., Saito, Y., Oriuchi, T., Suzuki, Y., Suzuki, S. (Susumu), Suzuki, S. (Shunji), Suzuki, S. (Shu), Suzuki, K. (Keita), Suzuki, K. (Kazuo), Sugimoto, C., Suga, T., Shozawa, Y., Shirai, T., Shinozuka, T., Shinohe, R., Shimoyama, Y., Shimono, H., Shiina, Y., Shibata, N., Sekine, Y., Seki, S., Sawano, M., Sato, K. (Kiyoharu), Sato, K. (Kazuki), Sasaki, A., Sasaguri, H., Sasagawa, Y., Samejima, Y., Sakamoto, Y., Sakamoto, N., Sakai, H., Oriso, S., Pearce, Y. Onuki, Ono, H., Okuyama, M., Okita, H., Okamoto, K., Ohara, N., Misumi, I., Shah, S., Purayil, M. Padinhare, Pothiwala, R. A., Chandwani, P., Kulkarni, G., Kishore, R., Chopda, M., Roy, D., Srinivas, A., Sarma, R., Bhargava, K., Rajput, R. K., Shankar, A. G. Ravi, Durgaprasad, R., Jadhav, P., Sawhney, J. P. S., Kakkar, S., Zhu, X. Y., Zhou, Z. H., Zhou, B., Zheng, W. Y., Zhang, Y., Zhang, R., Zhang, Q., Zhang, G. S., Zhan, Q., Zhai, H., Yu, T., Yu, J. H., Yu, H. Y., Ye, Y., Yang, Y. J., Yang, Q., Yang, L. L., Yang, J. S., Xu, R. Y., Xie, Q., Wu, R. N., Wang, L., Wang, K., Tian, G., Sun, Y. H., Shi, X. J., Sheng, X., Peng, J. Q., Ma, T. Y., Luo, X. L., Lu, Z. C., Liu, Y. Y., Liu, W. L., Liu, T. T., Li, Y. H., Li, L., Li, J., Li, B., Huang, X. F., Hu, X. S., He, X. A., He, R. H., Guo, W. N., Gao, X. J., Fu, Q. H., Feng, S., Chen, X., Chen, J. Y., Chen, J., Bai, C. L., Yang, Z. M., Wang, F. Z., Xue, L., Guo, Y., Jiao, Y., Chen, P., Xiong, L. G., Chen, M. S., Zhao, R. P., Yan, X. 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G., Vanajakshamma, V., Suresh, S., Singhal, S., Shiva, P., Sharma, M., Sadhu, N., Rao, N. M., Rao, M., Prashanth, K., Naik, D., More, P., Meena, R., Madarkar, N., Lokesh, B., Lawande, A., Krishnappa, S., Kaur, S., Kasala, L., Karthikeyan, R., Jain, V., Giradkar, S., Ganatra, A., Earath, M., Duhan, S., Dhyani, V., Dhakrao, P., Deshpande, B., Davies, D., Dargude, M., Bhattacharjee, P., Begum, H., Barai, A., Adak, D., Abraham, S., Jain, D., Kumar, S., Gupta, J. B., Khan, A., Bisne, V., Bantwal, G., Vijan, V. M., Vijayaraghavan, G., Raghuraman, B., Kothiwale, V. A., Chawla, K., Inagaki, K., Anno, T., Iseki, A., Horie, H., Narumi, J., Owari, M., Mizuguchi, I, Furukawa, Y., Matsumoto, N., Dorian, P., Tarrant, J., Cameron-Watts, J., Hegde, M. P., Dumikyan, A., Figura-Chmielewska, M., Alborough, E., Sabir, A., Reimer, D., Hergdt, G., Nierop, P. R., Baglioni, G., Viana, T., Vargas, T., Ely Pizzato, P., Drummond Wainstein, A. P., Ikitimur, B., Genc, D., Yoshida, T. (Tetsuro), Nagamalesh, U. M., Ishihara, A., Fu, G. S., Fox, Keith A. A., Flint, K., and Roesch, H.
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,Embolism ,Administration, Oral ,Hemorrhage ,Newly diagnosed ,030204 cardiovascular system & hematology ,Risk Assessment ,Risk profile ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Registries ,Stroke ,Aged ,Aged, 80 and over ,Fibrillation ,business.industry ,Anticoagulant ,Anticoagulants ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Stroke prevention ,Cohort ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Platelet Aggregation Inhibitors ,030217 neurology & neurosurgery - Abstract
Background Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective non-interventional study of stroke prevention in patients with newly diagnosed non-valvular AF (NAVF) that is being conducted in 35 countries. Methods and Results: A total of 52,081 patients with a new diagnosis of NVAF were enrolled prospectively in GARFIELD-AF. Of these, 4859 (9.3%) were recruited in Japan (2010-2016). In cohort 1 (2010-2011), few patients were on non-vitamin K antagonist oral anticoagulants (NOAC) globally. From cohort 2 onwards (2011-2016), however, there was a rapid increase in NOAC use around the globe, especially in Japan. By the last year of enrolment (2015-2016), 67.9% of patients in Japan and 43.1% of patients globally were on NOAC±antiplatelet therapy (AP). In Japan and globally, 17.0% and 12.2% of patients, respectively, did not receive stroke prevention treatment. Few patients in Japan (5.7%) received AP only. Compared with the other countries, the unadjusted rates of all-cause mortality and major bleeding were low, while rates of stroke/systemic embolism were similar after 1 year of follow-up. Conclusions GARFIELD-AF continues to provide important information on the homogeneity and heterogeneity of baseline characteristics and treatment patterns in patients with newly diagnosed NVAF. This diversity reflects the differences in outcomes in Japan compared with the rest of the world.
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- 2018
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30. The economic impact of hypercholesterolemia and mixed dyslipidemia: A systematic review of cost of illness studies
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Ferrara, Pietro, primary, Di Laura, Danilo, additional, Cortesi, Paolo A., additional, and Mantovani, Lorenzo G., additional
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- 2021
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31. Cardioversion in patients with newly diagnosed non-valvular atrial fibrillation: Observational study using prospectively collected registry data
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Pope, Marita Knudsen, Hall, Trygve S, Schirripa, Valentina, Radic, Petra, Virdone, Saverio, Pieper, Karen S, Le Heuzey, Jean-Yves, Jansky, Petr, Fitzmaurice, David A, Cappato, Riccardo, Atar, Dan, Camm, A John, Kakkar, Ajay K, Bassand, Jean-Pierre, Fox, Keith A A, Gersh, Bernard J, Goldhaber, Samuel Z, Goto, Shinya, Haas, Sylvia, Hacke, Werner, Mantovani, Lorenzo G, Misselwitz, Frank, Turpie, Alexander G G, van Eickels, Martin, Verheugt, Freek W A, Luciardi, Hector Lucas, Gibbs, Harry, Brodmann, Marianne, Cools, Frank, Barretto, Antonio Carlos Pereira, Connolly, Stuart J, Eikelboom, John, Corbalan, Ramon, Jing, Zhi-Cheng, Nielsen, Jørn Dalsgaard, Ragy, Hany, Raatikainen, Pekka, Darius, Harald, Keltai, Matyas, Sawhney, Jitendra Pal Singh, Agnelli, Giancarlo, Ambrosio, Giuseppe, Koretsune, Yukihiro, Sánchez Díaz, Carlos Jerjes, Ten Cate, Hugo, Stepinska, Janina, Panchenko, Elizaveta, Lim, Toon Wei, Jacobson, Barry, Oh, Seil, Viñolas, Xavier, Rosenqvist, Marten, Steffel, Jan, Angchaisuksiri, Pantep, Oto, Ali, Parkhomenko, Alex, Al Mahmeed, Wael, Hu, Dayi, Chen, Kangning, Zhao, Yusheng, Zhang, Huaiqin, Chen, Jiyan, Cao, Shiping, Wang, Daowen, Yang, Yuejin, Li, Weihua, Li, Hui, Yin, Yuehui, Tao, Guizhou, Yang, Ping, Chen, Yingmin, He, Shenghu, Wang, Yong, Fu, Guosheng, Li, Xin, Wu, Tongguo, Cheng, Xiaoshu, Yan, Xiaowei, Zhao, Ruiping, Chen, Moshui, Xiong, Longgen, Chen, Ping, Jiao, Yang, Guo, Ying, Xue, Li, Yang, Zhiming, Jadhavm, Praveen, Sarma, Raghava, Kulkarni, Govind, Chandwani, Prakash, Pothiwala, Rasesh Atulbhai, Purayil, Mohanan Padinhare, Chawla, Kamaldeep, Kothiwale, Veerappa Annasaheb, Raghuraman, Bagirath, Vijan, Vinod Madan, Sawhney, Jitendra, Bantwal, Ganapathi, Khan, Aziz, Meena, Ramdhan, Chopada, Manojkumar, Abraham, Sunitha, Bisne, Vikas, Vijayaraghavan, Govindan, Roy, Debabrata, Durgaprasad, Rajashekhar, Shankar, A G Ravi, Kumar, Sunil, Jain, Dinesh, Bhargava, Kartikeya, Kumar, Vinay, Nagamalesh, Udigala Madappa, Rajput, Rajeeve Kumar, 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Hidetoshi, Fujisawa, Kazuaki, Shiga, Yuhei, Sumi, Hirokuni, Nagatomo, Toshihisa, Atsuchi, Yoshihiko, Nagoshi, Toshiro, Sanno, Kazuhisa, Hoshino, Fumihiro, Yokota, Naoto, Kameko, Masahiro, Tabuchi, Toshifumi, Ishizawa, Munesumi, Fujiura, Yoshitake, Ikeda, Daisuke, Seto, Taku, Iwao, Tetsu, Ishioka, Norio, Oshiro, Koichi, Tsuchida, Keizo, Hatori, Yutaka, Takeuchi, Motoshi, Takezawa, Hiroto, Nagano, Shinjiro, Iwaki, Masaaki, Nakamura, Yuichiro, Miyamoto, Naomasa, Taguchi, Toshifumi, Ashida, Ko, Yoshizawa, Naoto, Agata, Jun, Matsukawa, Seishiro, Arasaki, Osamu, Fukuoka, Shuji, Murakami, Hirofumi, Mishima, Kazuya, Hata, Yoshiki, Sakuma, Ichiro, Obunai, Kotaro, Takamura, Ichiro, Akutsu, Mitsuyuki, Unoki, Toshihide, Go, Yoshinori, Ikemura, Makoto, Morii, Shoji, Marusaki, Shigeru, Doi, Hideo, Tanaka, Mitsuru, Kusumoto, Takaaki, Kakinoki, Shigeo, Ogurusu, Chiga, Murata, Kazuya, Shimoyama, Masaki, Nakatsuka, Masami, Kitami, Yutaka, Nakamura, Yoichi, Oda, Hiroshi, Oyama, Rikimaru, Ageta, Masato, 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Hatsuno, Taketo, Iwase, Takash, Sato, Kazuki, Kawai, Kazuya, Kotani, Tomobumi, Tsuji, Tsuyoshi, Sakai, Hirosumi, Nishino, Kiyoshi, Ikeda, Kenichi, Maeda, Kazuo, Shinozuka, Tomohiro, Inoue, Takeshi, Kawakami, Koichi, Kitazumi, Hiromichi, Takagi, Tsutomu, Hamaoka, Mamoru, Kojima, Jisho, Sasaki, Akitoshi, Tsuchiya, Yoshihiro, Betsuyaku, Tetsuo, Higuchi, Koji, Honda, Masaaki, Hasegawa, Koichi, Baba, Takao, Mineoi, Kazuaki, Koeda, Toshihiko, Hirasawa, Kunihiko, Kumazaki, Toshihide, Nakagomi, Akira, Otaki, Eiji, Shindo, Takashi, Hirayama, Hiroyoshi, Sugimoto, Chikako, Yamagishi, Takashi, Mizuguchi, Ichiro, Sezaki, Kazunori, Niwa, Isamu, Takenaka, Ken, Iiji, Osamu, Taya, Koichi, Kitazawa, Hitoshi, Ueda, Samu, Kakuda, Hirokazu, Ono, Takuya, Oriso, Seizo, Kamata, Junya, Nanke, Toshihiko, Maeda, Itaru, Matsuura, Yoshifusa, Teragawa, Hiroki, Maruyama, Yasuyuki, Takei, Kazuo, Horie, Hajime, Kito, Tetsutaro, Asano, Hiroshi, Matsushita, Koji, Nakamura, Masaichi, Washizuka, Takashi, Yoshida, Tomoki, 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Masahito, Ono, Shimato, Okamoto, Yutaka, Ubukata, Satoshi, Kodera, Kojiro, Oriuchi, Tatsuo, Matsumoto, Naoki, Inagaki, Koichi, Iseki, Atsushi, Yoshida, Tomohiro, Goda, Toshihiro, Katsuki, Tsukasa, Sato, Atsushi, Mori, Etsuo, Tsubokura, Toshio, Shudo, Hiroshi, Fujimoto, Shunichi, Katsuya, Tomohiro, Furukawa, Yoshiyuki, Hosokawa, Hiroshi, Narumi, Jun, Yamamoto, Kiichiro, Owari, Masaki, Inakura, Takuya, Anno, Takafumi, Shirakawa, Kazuyuki, Ching, Chi Keong, Foo, David, Wong, Kelvin, Yuyang, Tan, Park, Hui Nam, Kim, Woo-Shik, Lee, HyeYoung, Jang, Sung-Won, Kim, Dae Hyeok, Kim, Jun, Ryu, DongRyeol, Shim, Jaemin, Kim, Dae-Kyeong, Choi, Dong Ju, Oh, Yong Seog, Cho, Myeong-Chan, Kim, Hack-Lyoung, Jeon, Hui-Kyung, Shin, Dong-Gu, Park, Sang Weon, Park, Hoon Ki, Han, Sang-Jin, Sung, Jung Hoon, Park, Hyung-Wook, Nam, Gi-Byoung, On, Young Keun, Lim, Hong Euy, Kwak, JaeJin, Cha, Tae-Joon, Hong, Taek Jong, Park, Seong Hoon, Yoon, Jung Han, Kim, Nam-Ho, Kim, Kee-Sik, Jung, Byung Chun, Hwang, Gyo-Seung, Kim, Chong-Jin, Rungaramsin, Sakda, Katekangplu, Peerapat, Khunrong, Porames, Bunyapipat, Thanita, Wongcharoen, Wanwarang, Kaewsuwanna, Pinij, Siriwattana, Khanchai, Tiyanon, Waraporn, Pattanaprichakul, Supalerk, Likittanasombat, Khanchit, Cholsaringkarl, Doungrat, Boonyapisit, Warangkana, Cheewatanakornkul, Sirichai, Silaruks, Songkwan, Hutayanon, Pisit, Chawanadelert, Seksan, Chattranukulchai, Pairoj, Chatlaong, Boonsert, Santanakorn, Yingsak, Kanokphatcharakun, Khompiya, Mongkolwongroj, Piya, Jai-Aue, Sasivimon, Komson, Ongkarn, Altun, Armagan, Aydinlar, Ali, Topsakal, Ramazan, Ongen, Zeki, Acikel, Sadik, Sahin, Durmus Yildiray, Yilmaz, Ozcan, Yilmaz, Mehmet Birhan, Pekdemir, Hasan, Demir, Mesut, Sucu, Murat, Sahiner, Levent, Ersanli, Murat, Okuyan, Ertugrul, Aras, Dursun, Rolandi, Florencia, Ingaramo, Adrian Cesar, Sambadaro, Gustavo Alberto, Caputi, Vanina Fernandez, Luciardi, Hector, Berman, Sofia Graciela, Dragotto, Pablo, Kleiban, Andres Javier, Centurion, Nestor, Guerrero, Rodolfo Andres Ahuad, Di Paola, Leonel Adalberto, Dran, Ricardo Dario, Egido, Javier, Fosco, Matias Jose, Sinisi, Victor Alfredo, Cartasegna, Luis Rodolfo, Vilamajo, Oscar Gomez, Ramos, Jose Luis, Sassone, Sonia, Zapata, Gerardo, Conde, Diego, Giacomi, Guillermo, Fernandez, Alberto Alfredo, Berli, Mario Alberto, Ferroni, Fabian, Filho, Dário Celestino Sobral, Jaber, Jefferson, Armaganijan, Luciana Vidal, Costantini, Costantino Roberto Frack, Steffens, André, de Souzaem, Weimar Kunz Sebba Barroso, de Souza Neto, João David, Ribeiro, José Márcio, Teixeira, Marcelo Silveira, Rossi, Paulo, Pires, Leonardo, Moreira, Daniel, Jorge, José Carlos Moura, Filho, Adalberto Menezes Lorga, Bodanese, Luiz, Montera, Marcelo Westerlund, Del Carlo, Carlos Henrique, Saad, Jamil Abdalla, Alves da Costa, Fernando Augusto, Lopes, Renato, de Araújo, Gilson Roberto, Manenti, Euler Roberto, Saraiva, Jose Francisco Kerr, Braga, João Carlos Ferreira, Negri, Alexandre, Moncada, Carlos, Precoma, Dalton, Roquette, Fernando, Reis, Gilmar, Ramos Filho, Roberto Álvaro, Figueiredo, Estêvão Lanna, Botelho, Roberto Vieira, da Fontoura Tavares, Cláudio Munhoz, Finimundi, Helius Carlos, Kochi, Adriano, França, César Cássio Broilo, Alban, Fábio, Rosito, Guido Bernardo Aranha, Junior, João Batista de Moura Xavier Moraes, Tumelero, Rogério Tadeu, Maia, Lilia, de Almeida, Roberto Simões, do Carmo Borges, Ney Carter, Gomes Ferreira, Luís Gustavo, Corbalán, Ramón, Fernandez, Benjamin Aleck Joseh Stockins, Montecinos, Humberto, Lanas, Fernando, Gómez, Martín Larico, Astudillo, Carlos, Conejeros, Carlos, Cuevas, Patricio Marin, Forero, Alejandro, Gutiérrez, Claudio Bugueño, Aguilar, Juan, Cardenas, Sergio Potthoff, Eggers, German, Houzvic, Cesar, Rey, Carlos, Arriagada, Germán, Vilches, Gustavo Charme, Illescas Diaz, Jesus Jaime, Cantu, Raul Leal, Ramos Zavala, Maria Guadalupe, Jardines, Ricardo Cabrera, Zavaleta, Nilda Espinola, Rosas, Enrique Lopez, Llamas Esperón, Guillermo Antonio, Pozas, Gerardo, Muñoz, Ernesto Cardona, Hernandez, Norberto Matadamas, Rendon, Adolfo Leyva, Hernandez, Norberto Garcia, de los Rios Ibarra, Manuel, Carrillo, Luis Ramon Virgen, Villezca, David Lopez, Herrera, Carlos Hernandez, Lopez Prieto, Juan Jose, Rodriguez, Rodolfo Gaona, Espinosa, Efrain Villeda, Martinez, David Flores, Barcena, Jose Velasco, Fierro, Omar Fierro, Briones, Ignacio Rodriguez, Leiva Pons, Jose Luis, Lopez, Humberto Alvarez, Ruiz, Rafael Olvera, Brito, Carlos Gerardo Cantu, Valenzuela, Eduardo Julian Jose Roberto Chuquiure, Sanchez, Roxana Reyes, Bazzoni Ruiz, Alberto Esteban, Lopez Ruiz, Oscar Martin, Nava, Roberto Arriaga, Morales Cerda, Jesus David, Campos, Pedro Fajardo, Gonzalez, Mario Benavides, Lenz, Kurt, Hagn, Claus, Foechterle, Johannes, Drexel, Heinz, Huber, Kurt, Podczeck-Schweighofer, Andrea, Winkler, Michael, Schneeweiss, Bruno, Gegenhuber, Alfons, Lang, Wilfried, Eichinger-Hasenauer, Sabine, Kaserer, Peter, Sykora, Josef, Rasch, Heribert, Strohmer, Bernhard, Capiau, Luc, Vervoort, Geert, Wollaert, Bart, Hollanders, Geert, Vercammen, Jan, Faes, Dirk, Balthazar, Yohan, Delforge, Marc, Xhaet, Olivier, Striekwold, Harry, Thoeng, John, Hermans, Kurt, Mairesse, Georges, Anné, Wim, Blankoff, Ivan, Beutels, Michel, Verstraete, Stefan, Vandergoten, Peter, Purnode, Philippe, Godart, Pascal, Boussy, Tim, Desfontaines, Philippe, Heyse, Alex, Voet, Joeri, De Wolf, Axel, Zidkova, Eva, Spacek, Rudolf, Machova, Vilma, Ludka, Ondrej, Olsr, Josef, Kotik, Lubos, Racz, Blazej, Ferkl, Richard, Hubac, Jan, Kotik, Ilja, Monhart, Zdenek, Burianova, Hana, Jerabek, Ondrej, Pisova, Jana, Petrova, Iveta, Dedek, Vratislav, Honkova, Michaela, Podrazil, Petr, Reichert, Petr, Spinar, Jindrich, Novak, Miroslav, Durdil, Vaclav, Plocova, Katarina, Lastuvka, Jiri, Nielsen, Jørn, Husted, Steen, Dominguez, Helena, Hintze, Ulrik, Rasmussen, Søren, Sygehus, Næstved, Bremmelgaard, Arne, Markenvard, John, Børger, Jan, Solgaard, Jorgen, Eriksen, Ebbe, Løkkegaard, Thomas, Bruun, Michael, Mertz, Jacob, Schou, Morten, Olsen, Michael, Airaksinen, K E Juhani, Paganelli, Franck, Ohayon, Joël, Casassus, Frédéric, Galinier, Michel, Gottwalles, Yannick, Loiselet, Philippe, Muller, Jean-Joseph, Koujan, Mohamed Bassel, Marquand, André, Destrac, Sylvain, Piot, Olivier, Delarche, Nicolas, Cebron, Jean-Pierre, Guenoun, Maxime, Guedj-Meynier, Dominique, Lokesh, A G, Zuber, Mathieu, Amarenco, Pierre, Ellie, Emmanuel, Kadouch, James, Fournier, Pierre-Yves, Huberman, Jean-Pierre, Lemaire, Nestor, Rodier, Gilles, Vandamme, Xavier, Sibon, Igor, Neau, Jean-Philippe, Mahagne, Marie Hélène, Mielot, Antoine, Bonnefoy, Marc, Churet, Jean-Baptiste, Navarre, Vincent, Sellem, Frederic, Monniot, Gilles, Boyes, Jean-Paul, Doucet, Bernard, Martelet, Michel, Obadia, Désiré, Crousillat, Bernard, Mouallem, Joseph, Bearez, Etienne, Brugnaux, Jean Philippe, Fedorowsky, Alain, Nazeyrollas, Pierre, Berneau, Jean-Baptiste, Chemin, Frédéric, Schellong, Sebastien, Koeniger, Georg, Kopf, Andreas, Gerbaulet, 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Ebert, Hans-Holger, Schwencke, Carsten, Bernhardt, Peter, Karolyi, Laszlo, Sievers, Britta, Haverkamp, Wilhelm, Roehnisch, Jens-Uwe, Vertes, Andras, Szantai, Gabor, Matoltsy, Andras, Kanakaridisz, Nikosz, Boda, Zoltan, Kis, Erno, Gaszner, Balazs, Juhasz, Ferenc, Juhasz, Gizella, Kancz, Sandor, Laszlo, Zoltan, May, Zsolt, Merkely, Bela, Noori, Ebrahim, Habon, Tamas, Polgar, Peter, Szalai, Gabriella, Vangel, Sandor, Nagy, Andras, Engelthaler, Gabriella, Ferenczi, Judit, Egyutt, Mihaly, Martini, Giuliana, Cristina, Leone Maria, Tiraferri, Eros, Santoro, Rita, Testa, Sophie, Di Minno, Giovanni, Moia, Marco, Caimi, Teresa Maria, Tessitori, Maria, Cappelli, Roberto, Poli, Daniela, Quintavalla, Roberto, Cosmi, Franco, Fanelli, Raffaele, Oriana, Vincenzo, Reggio, Raffaele, Santi, Roberto, Pancaldi, Leonardo, De Cristofaro, Raimondo, Guazzaloca, Giuliana, De Blasio, Angelo, Uriate, Jorge Salerno, Lillo, Flavia, Pogliani, Enrico Maria, Bilo, Grzegorz, Accogli, Michele, Mariani, Antonio, Feola, 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Ogorek, Michal, Wozakowska-Kaplon, Beata, Loboz-Grudzien, Krystyna, Supinski, Wieslaw, Kuzniar, Jerzy, Zaluska, Roman, Hiczkiewicz, Jaroslaw, Swiatkowska-Byczynska, Lucyna, Kucharski, Lech, Gruchala, Marcin, Minc, Piotr, Olszewski, Maciej, Kania, Grzegorz, Krzciuk, Malgorzata, Lajkowski, Zbigniew, Ostrowska-Pomian, Bozenna, Lewczuk, Jerzy, Zinka, Elzbieta, Karczmarczyk, Agnieszka, Chmielnicka-Pruszczynska, Malgorzata, Wozniak-Skowerska, Iwona, Opolski, Grzegorz, Bronisz, Marek, Ogorek, Marcin, Glanowska, Grazyna, Ruszkowski, Piotr, Skonieczny, Grzegorz, Sciborski, Ryszard, Okopien, Boguslaw, Kukla, Piotr, Galbas, Krzysztof, Cymerman, Krzysztof, Jurowiecki, Jaroslaw, Miekus, Pawel, Myszka, Waldemar, Mazur, Stanislaw, Lysek, Roman, Baszak, Jacek, Rusicka-Piekarz, Teresa, Raczak, Grzegorz, Domanska, Ewa, Nessler, Jadwiga, Lesnik, Jozef, Eltishcheva, Vera, Libis, Roman, Kamalov, Gadel, Belenky, Dmitry, Egorova, Liudmila, Khokhlov, Alexander, Yakupov, Eduard, Zateyshchikov, Dmitry, Barbarash, Olga, Miller, Olga, Mazur, Evgeniy, Zrazhevskiy, Konstantin, Novikova, Tatyana, Moiseeva, Yulia, Polkanova, Elena, Sobolev, Konstantin, Rossovskaya, Maria, Shapovalova, Yulia, Kolesnikova, Alla, Nikolaev, Konstantin, Zemlianskaia, Oksana, Zateyshchikova, Anna, Kostenko, Victor, Popov, Sergey, Poltavskaya, Maria, Edin, Anton, Aleksandrova, Elena, Drapkina, Oksana, Vishnevsky, Alexander, Nagibovich, Oleg, Chizhov, Petr, Rachkova, Svetlana, Sergeev, Mikhail, Kurylo, Borys, Ushakov, Alexey, Vinolas, Xavier, Garcia, Pere Alvarez, Lopez Fernandez, Maria Fernanda, Sanchez, Luis Tercedor, Iparraguirre, Salvador Tranche, Monserrat, Pere Toran, Contreras, Emilio Marquez, Rafecas, Jordi Isart, Carrasco, Juan Motero, Pavia, Pablo Garcia, Pajuelo, Casimiro Gomez, Rincon Diaz, Luis Miguel, Iglesias Alonso, Luis Fernando, Ruiz, Angel Grande, Klein, Jordi Merce, Gonzalez Juanatey, Jose Ramon, Collado, Ines Monte, Piquero, Herminia Palacin, Cuixart, Carles Brotons, Escobar, Esther Fernandez, Bayo i Llibre, Joan, Vicente, Cecilia Corros, Gutierrez, Manuel Vida, Gonzalo, Francisco Epelde, Almeida Fernandez, Carlos Alexandre, Navarro, Encarnacion Martinez, Alia, Juan Jose Montero, Gonzalez, Maria Barreda, Oliva, Maria Angels Moleiro, Sanmartin, Jose Iglesias, Gonzalez, Mercedes Jimenez, Alvarez, Maria del Mar Rodriguez, Melenchon, Juan Herreros, Vera, Tomas Ripoll, Navarro, Manuel Jimenez, Caamano, Maria Vazquez, Arcocha Torres, Maria Fe, Gomez, Gonzalo Marcos, Romo, Andres Iniguez, Prieto Diaz, Miguel Angel, Rosenqvist, Mårten, Wirdby, Alexander, Lindén, Jan, Henriksson, Kerstin, Elmersson, Micael, Egilsson, Arnor, Börjesson, Ulf, Svärd, Gunnar, Liu, Bo, Lindh, Anders, Olsson, Lars-Bertil, Gustavsson, Mikael, Andersson, Lars, Benson, Lars, Bothin, Claes, Hajimirsadeghi, Ali, Martinsson, Björn, Ericsson, Marianne, Ohlsson, Åke, Lindvall, Håkan, Svensson, Peter, Thörne, Katarina, Händel, Hans, Platonov, Pyotr, Bernsten, Fredrik, Timberg, Ingar, Crisby, Milita, Karlsson, Jan-Erik, Andersson, Agneta, Malmqvist, Lennart, Engdahl, Johan, Thulin, Jörgen, Hot-Bjelak, Aida, Jensen, Steen, Stalby, Per, Debrunner, Johann, Beer, Juerg H, Shah, Dipen, Rudyk, Iurii, Tseluyko, Vira, Karpenko, Oleksandr, Zhurba, Svitlana, Kraiz, Igor, Parkhomenko, Oleksandr, Kupnovytska, Iryna, Seredyuk, Nestor, Mostovoy, Yuriy, Ushakov, Oleksiy, Koval, Olena, Kovalskiy, Igor, Svyshchenko, Yevgeniya, Sychov, Oleg, Stanislavchuk, Mykola, Yagensky, Andriy, Tykhonova, Susanna, Fushtey, Ivan, Murdoch, Will, Chauhan, Naresh, Goodwin, Daryl, Lumley, Louise, Patel, Ramila, Saunders, Philip, Wong, Bennett, Cameron, Alex, Patel, Niranjan, Jhittay, P, Ross, Andrew, Kainth, M S, Ladha, Karim, Douglas, Kevin, Pickavance, Gill, McDonnell, Joanna, Handscombe, Laura, Gooding, Trevor, Wagner, Helga, Bradshaw, Colin, Bromham, Catherine, Jones, Kevin, Suryani, Shoeb, Coates, Richard, Sarai, Bhupinder, Willcock, W, Sircar, S, Cairns, John, Gilliand, A, Bilas, Roman, Strieder, E, Hutchinson, Peter, Wakeman, Anne, Stokes, Michael, Kirby, Graham, Vishwanathan, Bhaskhar, Bird, Nigel, Evans, Paul, Clark, M, Bisatt, John, Litchfield, Jennifer, Fisher, E, Fooks, Tim, Kelsall, Richard, Paul, Neil, Alborough, Elizabeth, Aziz, Michael, Ramesh, C, Wilson, Pete, Franklin, Simon, Fairhead, Sue, Thompson, Julian, Chowan, Hasan, Taylor, Gary, Tragen, Dawn, Parfitt, Matt, Seamark, Claire, Paul, Carolyn, Richardson, Mark, Jefferies, Angus, Sharp, Helen, Jones, Hywel, Giles, Claire, Bramley, Matthew, Williams, Philip, Aldegather, Jehad, Wetherell, Simon, Lumb, William, Evans, Phil, Scouller, Frances, Macey, Neil, Rogers, Stephen, Stipp, Yvette, West, Richard, Pinney, Philip, Wadeson, Paul, Matthews, John, Pandya, Preeti, Gallagher, Andrew, Railton, T, Davies, Emyr, McClure, Jonathan, Jacobs, Marc, Hutton, Claire, Thompson, R, Sinha, Bijoy, Butter, Keith, Barrow, Susan, Little, Helen, Russell, David, Choudhary, Ulka, Haq, Ikram, Ainsworth, Paul, Jones, Claire, Weeks, Phil, Eden, Jane, Gibbons, Lisa, Glencross, Janet, MacLeod, Alison, Poland, K, Mulolland, Conor, Warke, A, Conn, Paul, Burns, D, Smith, R, Kamath, R, Webster, Jonathan, Hodgins, Ian, Vercoe, Stephen, Roome, Paul, Pinnock, Hilary, Patel, Jayesh, Ali, Amar, Hart, Nigel, Davies, Richard, De-Sousa, Nigel, Neden, Catherine, Danielsen, Mark, Sharma, Purnima, Galloway, Sophia, Hawkins, Charlotte, Oliver, Raife, Aylward, Martin, Pattni, Mira, Irvine, Gordon, Ahmad, Shahid, Rothwell, Catherine, Choudhary, Fiaz, Khalaque, Sabrina, Short, Stephanie, Peters, Sharon, Coulson, Warwick, Roberts, Neil, Butler, Amy, Coates, Steven, Ward, Ben, Jackson, Daniel, Walton, Steve, Shepherd, Diane, Wong, Toh, Boon, Mark, Deacon, Melanie, Cornelius, David, Davies, Sarah, Frankel, Ben, Hargreaves, Nick, Choi, Henry, Sumner, Jon, Myhill, Tim, Estifanos, Salah, Geatch, Diane, Wilkinson, Justin, Veale, Richard, Forshaw, Karen, Hirst, Rob, Zaman, Kashif, Liley, Catherine, Wastling, Rebecca, McEleny, Paul, Beattie, Andre, Cooke, Philip, Wong, Mike, Pugsley, Mark, Dooldeniya, Chaminda, Rogers, Greg, Bennett, James, Jacobs, Polly, Muvva, Rajesh, Adam, Matthew, Fox, Robin, Thomas, Nicolas, Cartwright, Simon, Reed, Rory, Randfield, Simon, A’Court, Christine, Flynn, Ann, Halpin, Andrew, Dobson, Simon, Lomax, Louise, Nadaph, Minnal, Munro, Iain, Goram, Jane, Stoddart, Helen, Simmons, Phil, Shewring, John, Bowen-Simpkins, Emma, Rickenbach, Mark, Blenkhorn, Adam, Singh, Bhuwanendu, Astridge, Penny, van Gaal, William, Abhayaratna, Walter, Thomson, Philip, Lehman, Ron, Kilian, Jens, Coulshed, David, Catanchin, Andrei, Colquhoun, David, Kiat, Hosen, Eccleston, David, French, John, Ayres, Bronte, Blombery, Peter, Phan, Thanh, Rogers, James, O’Donnell, David, Bae, Sang Cheol, Carroll, Patrick, Starmer, Greg, Arstall, Margaret, Binnekamp, Maurits, Lee, Astin, Luton, Robert, Gupta, Milan, Pandey, Amritanshu Shekhar, Cheung, Stephen, Leader, Rolland, Beaudry, Philippe, Ayala-Paredes, Félix, Berlingieri, Joseph, Heath, John, Poirier, Germain, du Preez, Miranda, Schweitzer, Bradley, Nadeau, Reginald, Dhillon, Ripple, Hruczkowski, Tomasz, Lavoie, Andrea, Parkash, Ratika, Cha, James, Coutu, Benoit, MacDonald, Paul, Ramjattan, Brian, Bonet, Jorge, Vizel, Saul, Angaran, Paul, Fikry, Sameh, Mowafy, Ahmed, Katta, Azza, Tawfik, Mazen, Nawar, Moustafa, Sobhy, Mohamed, Abou Seif, Seif Kamal, Khairy, Tarek, El-Aziz, Ahmed Abd, Taha, Nasser, Reda, Ashraf, Elbahry, Atef, Setiha, Mohamed, El Din, Mohamed Gamal, Elkhadem, Magdi, El-Etreby, Adel, Kettles, David, Bayat, Junaid, Siebert, Heidi, Horak, Adrian, Kelfkens, Ynez, Garda, Riaz, Pillay, Thayabran, Guerra, Michele, van Zyl, Louis, Theron, Hendrik, Murray, Andrew, Louw, Rikus, Greyling, Deon, Mntla, Pindile, Ismail, Siddique, Ahmed, Fayzal, Engelbrecht, Johannes, Maharajh, Shambu, Oosthuysen, Wessel, Loghdey, Rehana, Ueckermann, Veronica, Al Naeemi, Abdullah, Yousef, Ghazi, Bazargani, Nooshin, AlOmairi, Munther, Maruthanayagam, Rajan, Singh, Rupesh, Naguib, Ahmed, Ibrahim, Mohamed, Agrawal, Amrish, Nathani, Mukesh, Esheiba, Ehab M, Wassef, Adel, Gupta, Rajeev, Cox, Michael, Beach, Scott, Duffy, Peter, Falkowski, Stephen, Ferrick, Kevin, Franco, Miguel, Kutayli, W Michael, Quick, Annette, Sharma, Niraj, Wilson, Vance, Miller, Stephen, Alberts, Mark, Blumberg, Edwin, Canosa, Roddy, Gutowski, Ted, Ison, Rodney, Garcia, Jorge, Mullen, Paul, Noveck, Howard, Rama, Pamela, Reddy, Rajneesh, Williams, Marcus, Nishijima, Daniel, Ferdinand, Keith, Haque, Ihsan, Mendelson, Robert, Pitta, Sridevi, Theodoro, Daniel, Treasure, Charles, Moustafa, Moustafa, Cader, Cas, Pharr, Walter, Oropallo, Alisha, Platt, George, Gujral, Jaspal, Welker, James, and Koura, Firas
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Electric Countershock ,Therapeutics ,Cardioversion ,Lower risk ,Cause of Death ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Prospective Studies ,Registries ,Propensity Score ,Stroke ,Aged ,Proportional Hazards Models ,business.industry ,Proportional hazards model ,Research ,Anticoagulant ,Hazard ratio ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Propensity score matching ,Cardiology ,Female ,business ,RC - Abstract
OBJECTIVE To investigate the clinical outcomes of patients who underwent cardioversion compared with those who did not have cardioverson in a large dataset of patients with recent onset non-valvular atrial fibrillation. DESIGN Observational study using prospectively collected registry data (Global Anticoagulant Registry in the FIELD-AF-GARFIELD-AF). SETTING 1317 participating sites in 35 countries. PARTICIPANTS 52 057 patients aged 18 years and older with newly diagnosed atrial fibrillation (up to six weeks' duration) and at least one investigator determined stroke risk factor. MAIN OUTCOME MEASURES Comparisons were made between patients who received cardioversion and those who had no cardioversion at baseline, and between patients who received direct current cardioversion and those who had pharmacological cardioversion. Overlap propensity weighting with Cox proportional hazards models was used to evaluate the effect of cardioversion on clinical endpoints (all cause mortality, non-haemorrhagic stroke or systemic embolism, and major bleeding), adjusting for baseline risk and patient selection. RESULTS 44 201 patients were included in the analysis comparing cardioversion and no cardioversion, and of these, 6595 (14.9%) underwent cardioversion at baseline. The propensity score weighted hazard ratio for all cause mortality in the cardioversion group was 0.74 (95% confidence interval 0.63 to 0.86) from baseline to one year follow-up and 0.77 (0.64 to 0.93) from one year to two year follow-up. Of the 6595 patients who had cardioversion at baseline, 299 had a follow-up cardioversion more than 48 days after enrolment. 7175 patients were assessed in the analysis comparing type of cardioversion: 2427 (33.8%) received pharmacological cardioversion and 4748 (66.2%) had direct current cardioversion. During one year follow-up, event rates (per 100 patient years) for all cause mortality in patients who received direct current and pharmacological cardioversion were 1.36 (1.13 to 1.64) and 1.70 (1.35 to 2.14), respectively. OBJECTIVE To investigate the clinical outcomes of patients who underwent cardioversion compared with those who did not have cardioverson in a large dataset of patients with recent onset non-valvular atrial fibrillation. DESIGN Observational study using prospectively collected registry data (Global Anticoagulant Registry in the FIELD-AF-GARFIELD-AF). SETTING 1317 participating sites in 35 countries. PARTICIPANTS 52 057 patients aged 18 years and older with newly diagnosed atrial fibrillation (up to six weeks' duration) and at least one investigator determined stroke risk factor. MAIN OUTCOME MEASURES Comparisons were made between patients who received cardioversion and those who had no cardioversion at baseline, and between patients who received direct current cardioversion and those who had pharmacological cardioversion. Overlap propensity weighting with Cox proportional hazards models was used to evaluate the effect of cardioversion on clinical endpoints (all cause mortality, non-haemorrhagic stroke or systemic embolism, and major bleeding), adjusting for baseline risk and patient selection. RESULTS 44 201 patients were included in the analysis comparing cardioversion and no cardioversion, and of these, 6595 (14.9%) underwent cardioversion at baseline. The propensity score weighted hazard ratio for all cause mortality in the cardioversion group was 0.74 (95% confidence interval 0.63 to 0.86) from baseline to one year follow-up and 0.77 (0.64 to 0.93) from one year to two year follow-up. Of the 6595 patients who had cardioversion at baseline, 299 had a follow-up cardioversion more than 48 days after enrolment. 7175 patients were assessed in the analysis comparing type of cardioversion: 2427 (33.8%) received pharmacological cardioversion and 4748 (66.2%) had direct current cardioversion. During one year follow-up, event rates (per 100 patient years) for all cause mortality in patients who received direct current and pharmacological cardioversion were 1.36 (1.13 to 1.64) and 1.70 (1.35 to 2.14), respectively. CONCLUSION In this large dataset of patients with recent onset non-valvular atrial fibrillation, a small proportion were treated with cardioversion. Direct current cardioversion was performed twice as often as pharmacological cardioversion, and there appeared to be no major difference in outcome events for these two cardioversion modalities. For the overall cardioversion group, after adjustments for confounders, a significantly lower risk of mortality was found in patients who received early cardioversion compared with those who did not receive early cardioversion. STUDY REGISTRATION ClinicalTrials.gov NCT01090362.
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- 2021
32. The economic impact of hypercholesterolemia and mixed dyslipidemia: A systematic review of cost of illness studies
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Ferrara, P, Di Laura, D, Cortesi, P, Mantovani, L, Ferrara, Pietro, Di Laura, Danilo, Cortesi, Paolo A, Mantovani, Lorenzo G, Ferrara, P, Di Laura, D, Cortesi, P, Mantovani, L, Ferrara, Pietro, Di Laura, Danilo, Cortesi, Paolo A, and Mantovani, Lorenzo G
- Abstract
Hypercholesterolemia is a clinically relevant condition with an ascertained role in atherogenesis. In particular, its presence directly correlates to the risk of atherosclerotic cardiovascular disease (ASCVD). As known, cardiovascular diseases pose a significant economic burden worldwide; however, a clear picture of the economic impact of ASCVD secondary to hypercholesterolemia is lacking. This study aiming at conducting a systematic review of the current literature to assess the economic impact of familial hypercholesterolemia (FH), non-familial hypercholesterolemia (non-FH) or mixed dyslipidemia. A literature search was performed in Medline/PubMed and Embase database up to September 1st, 2020, exploring evidence published from 2010. The literature review was conducted in accordance with PRISMA guidelines. To be included the studies must be conducted on people who have been diagnosed with familial hypercholesterolemia, non-familial hypercholesterolemia or mixed dyslipidemia, and report data/information on costs attributable to these conditions and their sequelae. A total of 1260 studies were retrieved. After reading the titles and abstract, 103 studies were selected for full reading and eight met the criteria for inclusion. All but one studies were published in the American continent, with the majority conducted in US. An observational design with a prevalence approach were used and all estimated the economic burden of CVD. Direct cost estimates as annual average health expenditure on all population, ranging from $17 to $259 million. Few studies assessing the economic impact of hypercholesterolemia are available in the literature and new researches are needed to provide a more updated and reliable picture. Despite this scarceness of evidence, this review adds important data for future discussion on the knowledge of the economic impact of hypercholesterolemia and costs of care associated to this condition, with important implication for public health researches and
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- 2021
33. Pregnancy-Associated Venous Thromboembolism: Insights from GARFIELD-VTE
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Jerjes-Sánchez, C, Rodriguez, D, Farjat, A, Kayani, G, Maccallum, P, Lopes, R, Turpie, A, Weitz, J, Haas, S, Ageno, W, Goto, S, Goldhaber, S, Angchaisuksiri, P, Nielsen, J, Schellong, S, Bounameaux, H, Mantovani, L, Prandoni, P, Kakkar, A, Jerjes-Sánchez, Carlos, Rodriguez, David, Farjat, Alfredo E, Kayani, Gloria, MacCallum, Peter, Lopes, Renato D, Turpie, Alexander G G, Weitz, Jeffrey I, Haas, Sylvia, Ageno, Walter, Goto, Shinya, Goldhaber, Samuel Z, Angchaisuksiri, Pantep, Nielsen, Joern Dalsgaard, Schellong, Sebastian, Bounameaux, Henri, Mantovani, Lorenzo G, Prandoni, Paolo, Kakkar, Ajay K, Jerjes-Sánchez, C, Rodriguez, D, Farjat, A, Kayani, G, Maccallum, P, Lopes, R, Turpie, A, Weitz, J, Haas, S, Ageno, W, Goto, S, Goldhaber, S, Angchaisuksiri, P, Nielsen, J, Schellong, S, Bounameaux, H, Mantovani, L, Prandoni, P, Kakkar, A, Jerjes-Sánchez, Carlos, Rodriguez, David, Farjat, Alfredo E, Kayani, Gloria, MacCallum, Peter, Lopes, Renato D, Turpie, Alexander G G, Weitz, Jeffrey I, Haas, Sylvia, Ageno, Walter, Goto, Shinya, Goldhaber, Samuel Z, Angchaisuksiri, Pantep, Nielsen, Joern Dalsgaard, Schellong, Sebastian, Bounameaux, Henri, Mantovani, Lorenzo G, Prandoni, Paolo, and Kakkar, Ajay K
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Introduction The risk of venous thromboembolism (VTE) increases during pregnancy and the puerperium such that VTE is a leading cause of maternal mortality. Methods We describe the clinical characteristics, diagnostic strategies, treatment patterns, and outcomes of women with pregnancy-associated VTE (PA-VTE) enrolled in the Global Anticoagulant Registry in the FIELD (GARFIELD)-VTE. Women of childbearing age (<45 years) were stratified into those with PA-VTE ( n =183), which included pregnant patients and those within the puerperium, and those with nonpregnancy associated VTE (NPA-VTE; n =1,187). Patients with PA-VTE were not stratified based upon the stage of pregnancy or puerperium. Results Women with PA-VTE were younger (30.5 vs. 34.8 years), less likely to have pulmonary embolism (PE) (19.7 vs. 32.3%) and more likely to have left-sided deep vein thrombosis (DVT) (73.9 vs. 54.8%) compared with those with NPA-VTE. The most common risk factors in PA-VTE patients were hospitalization (10.4%), previous surgery (10.4%), and family history of VTE (9.3%). DVT was typically diagnosed by compression ultrasonography (98.7%) and PE by chest computed tomography (75.0%). PA-VTE patients more often received parenteral (43.2 vs. 15.1%) or vitamin K antagonists (VKA) (9.3 vs. 7.6%) therapy alone. NPA-VTE patients more often received a DOAC alone (30.2 vs. 13.7%). The risk (hazard ratio [95% confidence interval]) of all-cause mortality (0.59 [0.18-1.98]), recurrent VTE (0.82 [0.34-1.94]), and major bleeding (1.13 [0.33-3.90]) were comparable between PA-VTE and NPA-VTE patients. Uterine bleeding was the most common complication in both groups. Conclusion VKAs or DOACs are widely used for treatment of PA-VTE despite limited evidence for their use in this population. Rates of clinical outcomes were comparable between groups.
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- 2021
34. Costs and effects of cardiovascular risk reclassification using the ankle-brachial index (ABI) in addition to the Framingham risk scoring in women
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Cortesi, P, Maloberti, A, Micale, M, Pagliarin, F, Antonazzo, I, Mazzaglia, G, Giannattasio, C, Mantovani, L, Cortesi, Paolo Angelo, Maloberti, Alessandro, Micale, Mariangela, Pagliarin, Federica, Antonazzo, Ippazio C., Mazzaglia, Giampiero, Giannattasio, Cristina, Mantovani, Lorenzo G., Cortesi, P, Maloberti, A, Micale, M, Pagliarin, F, Antonazzo, I, Mazzaglia, G, Giannattasio, C, Mantovani, L, Cortesi, Paolo Angelo, Maloberti, Alessandro, Micale, Mariangela, Pagliarin, Federica, Antonazzo, Ippazio C., Mazzaglia, Giampiero, Giannattasio, Cristina, and Mantovani, Lorenzo G.
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Background and aims: Ankle brachial index (ABI) is a simple and cheap parameter to assess the presence of atherosclerosis. It could also help correctly reclassify the cardiovascular risk when added to the Framingham risk score (FRS). Recent evidence has demonstrated improvement in prediction performance of ABI when added to FRS, particularly in women. However, no studies have been published yet evaluating the cost-effectiveness of this approach. This study attempts to fill in this gap by assessing the cost-effectiveness of ABI measurements in primary prevention in women. Methods: We developed a Markov model to compare two different strategies for assessing the cardiovascular risk (low, intermediate and high) among women in the general population: 1) FRS strategy, and 2) FRS + ABI strategy; and the relative impact associated with interventions for preventing CV events in intermediate and high-risk categories. Results: In the base-case analysis, FRS + ABI reported an additional cost of € 110 and a gain of 0.0039 QALYs per patient, resulting in an ICER of € 27.986/QALY, when compared to FRS alone. The ICER improved to €1.641/QALY when using a lifetime horizon. The effectiveness of preventive CV disease interventions reported also a significant impact. A 32% reduction of CV events was the minimum value estimated to maintain FRS + ABI as a cost-effective strategy. Conclusions: The addition of ABI to FRS is a cost-effective approach in women classified at low and intermediate risk with FRS only. This new approach gives the possibility to reclassify and allocate them into the appropriate risk group and treatment.
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- 2021
35. Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation
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Fox, Keith AA, Lucas, Joseph E, Pieper, Karen S, Bassand, Jean-Pierre, Camm, A John, Fitzmaurice, David A, Goldhaber, Samuel Z, Goto, Shinya, Haas, Sylvia, Hacke, Werner, Kayani, Gloria, Oto, Ali, Mantovani, Lorenzo G, Misselwitz, Frank, Piccini, Jonathan P, Turpie, Alexander GG, Verheugt, Freek WA, Kakkar, Ajay K, GARFIELD-AF Investigators, Fox, Keith AA [0000-0002-0140-2752], and Apollo - University of Cambridge Repository
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Aged, 80 and over ,Male ,Internationality ,Time Factors ,Anticoagulants ,Hemorrhage ,risk stratification ,Kaplan-Meier Estimate ,Middle Aged ,Risk Assessment ,Severity of Illness Index ,Stroke ,ROC Curve ,CHA2DS2-VASc ,Risk Factors ,Cause of Death ,Atrial Fibrillation ,Humans ,Regression Analysis ,Female ,Prospective Studies ,Registries ,Aged - Abstract
OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was developed, using stepwise regression, for all and then applied to lower risk patients. C-statistics were compared with CHA2DS2-VASc using 30-fold cross-validation to control for overfitting. External validation was undertaken in an independent dataset, Outcome Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). PARTICIPANTS: Data from 39 898 patients enrolled in the prospective GARFIELD-AF registry provided the basis for deriving and validating an integrated risk tool to predict stroke risk, mortality and bleeding risk. RESULTS: The discriminatory value of the GARFIELD-AF risk model was superior to CHA2DS2-VASc for patients with or without anticoagulation. C-statistics (95% CI) for all-cause mortality, ischaemic stroke/systemic embolism and haemorrhagic stroke/major bleeding (treated patients) were: 0.77 (0.76 to 0.78), 0.69 (0.67 to 0.71) and 0.66 (0.62 to 0.69), respectively, for the GARFIELD-AF risk models, and 0.66 (0.64-0.67), 0.64 (0.61-0.66) and 0.64 (0.61-0.68), respectively, for CHA2DS2-VASc (or HAS-BLED for bleeding). In very low to low risk patients (CHA2DS2-VASc 0 or 1 (men) and 1 or 2 (women)), the CHA2DS2-VASc and HAS-BLED (for bleeding) scores offered weak discriminatory value for mortality, stroke/systemic embolism and major bleeding. C-statistics for the GARFIELD-AF risk tool were 0.69 (0.64 to 0.75), 0.65 (0.56 to 0.73) and 0.60 (0.47 to 0.73) for each end point, respectively, versus 0.50 (0.45 to 0.55), 0.59 (0.50 to 0.67) and 0.55 (0.53 to 0.56) for CHA2DS2-VASc (or HAS-BLED for bleeding). Upon validation in the ORBIT-AF population, C-statistics showed that the GARFIELD-AF risk tool was effective for predicting 1-year all-cause mortality using the full and simplified model for all-cause mortality: C-statistics 0.75 (0.73 to 0.77) and 0.75 (0.73 to 0.77), respectively, and for predicting for any stroke or systemic embolism over 1 year, C-statistics 0.68 (0.62 to 0.74). CONCLUSIONS: Performance of the GARFIELD-AF risk tool was superior to CHA2DS2-VASc in predicting stroke and mortality and superior to HAS-BLED for bleeding, overall and in lower risk patients. The GARFIELD-AF tool has the potential for incorporation in routine electronic systems, and for the first time, permits simultaneous evaluation of ischaemic stroke, mortality and bleeding risks. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier for GARFIELD-AF (NCT01090362) and for ORBIT-AF (NCT01165710).
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- 2020
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36. Magnitude and time-course of excess mortality during COVID-19 outbreak: population-based empirical evidence from highly impacted provinces in northern Italy
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Conti, S, Ferrara, P, Mazzaglia, G, D'Orso, M, Ciampichini, R, Fornari, C, Madotto, F, Magoni, M, Sampietro, G, Silenzi, A, Sileo, C, Zucchi, A, Cesana, G, Manzoli, L, Mantovani, L, Conti, Sara, Ferrara, Pietro, Mazzaglia, Giampiero, D'Orso, Marco I., Ciampichini, Roberta, Fornari, Carla, Madotto, Fabiana, Magoni, Michele, Sampietro, Giuseppe, Silenzi, Andrea, Sileo, Claudio V., Zucchi, Alberto, Cesana, Giancarlo, Manzoli, Lamberto, Mantovani, Lorenzo G., Conti, S, Ferrara, P, Mazzaglia, G, D'Orso, M, Ciampichini, R, Fornari, C, Madotto, F, Magoni, M, Sampietro, G, Silenzi, A, Sileo, C, Zucchi, A, Cesana, G, Manzoli, L, Mantovani, L, Conti, Sara, Ferrara, Pietro, Mazzaglia, Giampiero, D'Orso, Marco I., Ciampichini, Roberta, Fornari, Carla, Madotto, Fabiana, Magoni, Michele, Sampietro, Giuseppe, Silenzi, Andrea, Sileo, Claudio V., Zucchi, Alberto, Cesana, Giancarlo, Manzoli, Lamberto, and Mantovani, Lorenzo G.
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Background The real impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on overall mortality remains uncertain as surveillance reports have attributed a limited number of deaths to novel coronavirus disease 2019 (COVID-19) during the outbreak. The aim of this study was to assess the excess mortality during the COVID-19 outbreak in highly impacted areas of northern Italy. Methods We analysed data on deaths that occurred in the first 4 months of 2020 provided by the health protection agencies (HPAs) of Bergamo and Brescia (Lombardy), building a time-series of daily number of deaths and predicting the daily standardised mortality ratio (SMR) and cumulative number of excess deaths through a Poisson generalised additive model of the observed counts in 2020, using 2019 data as a reference.Results We estimated that there were 5740 (95% credible set (CS) 5552–5936) excess deaths in the HPA of Bergamo and 3703 (95% CS 3535–3877) in Brescia, corresponding to a 2.55-fold (95% CS 2.50–2.61) and 1.93 (95% CS 1.89–1.98) increase in the number of deaths. The excess death wave started a few days later in Brescia, but the daily estimated SMR peaked at the end of March in both HPAs, roughly 2 weeks after the introduction of lockdown measures, with significantly higher estimates in Bergamo (9.4, 95% CI 9.1–9.7). Conclusion Excess mortality was significantly higher than that officially attributed to COVID-19, disclosing its hidden burden likely due to indirect effects on the health system. Time-series analyses highlighted the impact of lockdown restrictions, with a lower excess mortality in the HPA where there was a smaller delay between the epidemic outbreak and their enforcement.
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- 2020
37. Estimates of the initial impact of the COVID-19 epidemic on overall mortality: evidence from Italy
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Conti, S, Ferrara, P, Fornari, C, Harari, S, Madotto, F, Silenzi, A, Zucchi, A, Manzoli, L, Mantovani, L, Conti, Sara, Ferrara, Pietro, Fornari, Carla, Harari, Sergio, Madotto, Fabiana, Silenzi, Andrea, Zucchi, Alberto, Manzoli, Lamberto, Mantovani, Lorenzo G., Conti, S, Ferrara, P, Fornari, C, Harari, S, Madotto, F, Silenzi, A, Zucchi, A, Manzoli, L, Mantovani, L, Conti, Sara, Ferrara, Pietro, Fornari, Carla, Harari, Sergio, Madotto, Fabiana, Silenzi, Andrea, Zucchi, Alberto, Manzoli, Lamberto, and Mantovani, Lorenzo G.
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- 2020
38. Treatment with ACE inhibitors or ARBs and risk of severe/lethal COVID-19: a meta-analysis
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Flacco, M, Acuti Martellucci, C, Bravi, F, Parruti, G, Cappadona, R, Mascitelli, A, Manfredini, R, Mantovani, L, Manzoli, L, Flacco, Maria Elena, Acuti Martellucci, Cecilia, Bravi, Francesca, Parruti, Giustino, Cappadona, Rosaria, Mascitelli, Alfonso, Manfredini, Roberto, Mantovani, Lorenzo G, Manzoli, Lamberto, Flacco, M, Acuti Martellucci, C, Bravi, F, Parruti, G, Cappadona, R, Mascitelli, A, Manfredini, R, Mantovani, L, Manzoli, L, Flacco, Maria Elena, Acuti Martellucci, Cecilia, Bravi, Francesca, Parruti, Giustino, Cappadona, Rosaria, Mascitelli, Alfonso, Manfredini, Roberto, Mantovani, Lorenzo G, and Manzoli, Lamberto
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Objective: It has been hypothesised that the use of ACE inhibitors and angiotensin receptor blockers (ARBs) might either increase or reduce the risk of severe or lethal COVID-19. The findings from the available observational studies varied, and summary estimates are urgently needed to elucidate whether these drugs should be suspended during the pandemic, or patients and physicians should be definitely reassured. This meta-analysis of adjusted observational data aimed to summarise the existing evidence on the association between these medications and severe/lethal COVID-19. Methods: We searched MedLine, Scopus and preprint repositories up to 8 June 2020 to retrieve cohort or case-control studies comparing the risk of severe/fatal COVID-19 (either mechanical ventilation, intensive care unit admission or death), among hypertensive subjects treated with: (1) ACE inhibitors, (2) ARBs and (3) both, versus untreated subjects. Data were combined using a random-effect generic inverse variance approach. Results: Ten studies, enrolling 9890 hypertensive subjects were included in the analyses. Compared with untreated subjects, those using either ACE inhibitors or ARBs showed a similar risk of severe or lethal COVID-19 (summary OR: 0.90; 95% CI 0.65 to 1.26 for ACE inhibitors; 0.92; 95% CI 0.75 to 1.12 for ARBs). The results did not change when both drugs were considered together, when death was the outcome and excluding the studies with significant, divergent results. Conclusion: The present meta-analysis strongly supports the recommendation of several scientific societies to continue ARBs or ACE inhibitors for all patients, unless otherwise advised by their physicians who should thus be reassured.
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- 2020
39. Cost-Effectiveness Analysis of Cannabinoid Oromucosal Spray Use for the Management of Spasticity in Subjects with Multiple Sclerosis
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Mantovani, Lorenzo G, Cozzolino,, Paolo, Cortesi, Paolo A, Patti,, Francesco, Mirabella, Massimiliano, Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Mantovani, Lorenzo G, Cozzolino,, Paolo, Cortesi, Paolo A, Patti,, Francesco, Mirabella, Massimiliano, and Mirabella, Massimiliano (ORCID:0000-0002-7783-114X)
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INTRODUCTION: Multiple sclerosis (MS) is a highly symptomatic disease, with a wide range of disabilities affecting many bodily functions, even in younger persons with a short disease history. The availability of a cannabinoid oromucosal spray (Sativex) for the management of treatment-resistant MS spasticity has provided a new opportunity for many patients. OBJECTIVE: Our study aimed to assess the cost effectiveness of Sativex in Italian patients with treatment-resistant MS spasticity. The analysis was based on the real-world data of a large registry of Italian patients. METHODS: A cost-utility analysis was conducted using data collected prospectively from an electronic registry of all patients who began to use Sativex for MS-resistant spasticity between January 2014 and February 2015 in 30 specialized MS units across Italy and were followed up for ≤ 6 months. Data on drug consumption and spasticity/utility were used to estimate the incremental cost-effectiveness ratio (ICER) of Sativex, as compared with no intervention. No costs or spasticity/utility changes were assumed for no treatment intervention. The ICER was expressed as quality-adjusted life-years (QALYs) gained, using the Italian NHS perspective and a 6-month time horizon. RESULTS: Sativex effectiveness and consumption was estimated analyzing data of 1350 patients from the registry. These patients reported a mean (SD) utility increment of 0.087 (0.069) after 1 month of treatment, 0.118 (0.073) after 3 months' treatment and 0.127 (0.080) after 6 months' treatment. The 6-month cost of treating the entire population with Sativex was €1,361,266, with a €1008 cost and 0.0284 QALYs gained per patient. The estimated ICER was €35,516 per QALY gained, with little variability around the central estimate of cost-effectiveness, as shown by the cost-effectiveness acceptability curve. CONCLUSION: The use of Sativex could improve the quality of life of patients with a reasonable incremental cost resulting as a cost-effecti
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- 2020
40. Device therapy and hospital reimbursement practices across European countries: a heterogeneous scenario
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Boriani, Giuseppe, Burri, Haran, Mantovani, Lorenzo G., Maniadakis, Nikos, Leyva, Francisco, Kautzner, Joseph, Lubinski, Andrzej, Braunschweig, Frieder, Jung, Werner, Lozano, Ignacio F., and Fattore, Giovanni
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- 2011
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41. Cardiac resynchronization therapy: a cost or an investment?
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Boriani, Giuseppe, Mantovani, Lorenzo G., Biffi, Mauro, Schalij, Martin J., Martignani, Cristian, Leclercq, Christophe, Bax, Jeroen J., and Auricchio, Angelo
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- 2011
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42. Health technology assessment: what is it? Current status and perspectives in the field of electrophysiology
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Fattore, Giovanni, Maniadakis, Nikos, Mantovani, Lorenzo G., and Boriani, Giuseppe
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- 2011
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43. Economic evaluation in cardiology
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Maniadakis, Nikos, Vardas, Panos, Mantovani, Lorenzo G., Fattore, Giovanni, and Boriani, Giuseppe
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- 2011
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44. Magnitude and time-course of excess mortality during COVID-19 outbreak: population-based empirical evidence from highly impacted provinces in northern Italy
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Conti, Sara, primary, Ferrara, Pietro, additional, Mazzaglia, Giampiero, additional, D'Orso, Marco I., additional, Ciampichini, Roberta, additional, Fornari, Carla, additional, Madotto, Fabiana, additional, Magoni, Michele, additional, Sampietro, Giuseppe, additional, Silenzi, Andrea, additional, Sileo, Claudio V., additional, Zucchi, Alberto, additional, Cesana, Giancarlo, additional, Manzoli, Lamberto, additional, and Mantovani, Lorenzo G., additional
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- 2020
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45. Estimates of the initial impact of the COVID-19 epidemic on overall mortality: evidence from Italy
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Conti, Sara, primary, Ferrara, Pietro, additional, Fornari, Carla, additional, Harari, Sergio, additional, Madotto, Fabiana, additional, Silenzi, Andrea, additional, Zucchi, Alberto, additional, Manzoli, Lamberto, additional, and Mantovani, Lorenzo G., additional
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- 2020
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46. Predictors of NOAC versus VKA use for stroke prevention in patients with newly diagnosed atrial fibrillation: Results from GARFIELD-AF
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Lesnik, J., Tabuchi, T., Seto, T., Nagoshi, T., Atsuchi, Y., Fujisawa, K., Sanno, K., Nagatomo, T., Sumi, H., Shiga, Y. (Yuhei), Morii, S., Unoki, T., Mishima, K., Go, Y., Oda, H. (Hiroyuki), Ageta, M., Oyama, R., Nakamura, Y. (Yoichi), Kitami, Y., Hatori, Y., Takeuchi, M., Tsuchida, K., Iwao, T., Yokota, N., Hoshino, F., Takamura, I, Akutsu, M., Shimoyama, M., Ogurusu, C., Murata, K., Nakatsuka, M., Ishizawa, M., Fujiura, Y. (Yoshitake), Ikeda, D., Yoshida, H., Eto, T., Gushiken, M., Higa, S., Kuwahata, T., Oba, I, Tachibana, H., Obunai, K., Fudo, T., Saito, K. (Kazuyuki), Saito, K. (Katsumi), Tsunoda, S., Kihara, H., Abe, S., Maekawa, H., Yamasawa, M., Wakasa, Y., Murakami, K., Kamogawa, Y., Tatematsu, H., Ogawa, J., Numata, H., Yoshimura, A., Fujiura, Y. (Yoshihisa), Zaitsu, R., Nandate, H., Nakamura, T. (Tsugihiro), Nakamura, T. (Tadashi), Kato, H., Miyagi, H., Suefuji, H., Haraguchi, Y., Minoda, K., Goto, K., Sonoda, R., Cheng, X. S., Wu, T. G., Li, X., Fu, G. S., Wang, Y. 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Neden, C, Danielsen, M, Heath, R, Sharma, P, Galloway, S, Hawkins, C, Oliver, R, Aylward, M, Mannion, S, Braddick, M, Edwards, D, Rothwell, A, Sabir, A, Choudhary, F, Khalaque, S, Wilson, A, Peters, S, Coulson, W, Roberts, N, Heer, A, Coates, S, Ward, B, Jackson, D, Walton, S, Shepherd, D, Sterry, M, Wong, T, Boon, M, Bunney, R, Haria-Shah, R, Baron, R, Davies, S, Schatzberger, T, Hargreaves, N, Stephenson, T, Batson, R, Lucraft, L, Myhill, T, Estifano, S, Geatch, D, Wilkinson, J, Veale, R, Forshaw, K, Davies, T, Zaman, K, Vinson, P, Liley, C, Bandrapalli, M, Mcginty, P, Wastling, R, Mceleny, P, Beattie, A, Cooke, P, Wong, M, Gunasegaram, J, Pugsley, M, Ahmad, S, A'Court, C, Ayers, J, Bennett, J, Cartwright, S, Dobson, S, Dooldeniya, C, Flynn, A, Fox, R, Goram, J, Halpin, A, Hay, A, Jacobs, P, Jeffers, L, Lomax, L, Munro, I, Muvva, R, Nadaph, M, Powell, K, Randfield, S, Redpath, D, Reed, R, Rickenbach, M, Rogers, G, Seamark, C, Shewring, J, Simmons, P, Simper, H, Stoddart, H, Sword, A, Thomas, N, Thomson, A, Blenkhorn, A, Singh, B, Van Gaal, W, Abhayaratna, W, Lehman, R, Roberts-Thomson, P, Kilian, J, Coulshed, D, Catanchin, A, Colquhoun, D, Kiat, H, Eccleston, D, French, J, Zimmett, L, Ayres, B, Phan, T, Blombery, P, Crimmins, D, O'Donnell, D, Choi, A, Astridge, P, Arstall, M, Jepson, N, Binnekamp, M, Lee, A, Rogers, J, Starmer, G, Carroll, P, Faunt, J, Aggarwala, A, Barry, L, Batta, C, Beveridge, R, Black, A, Bonner, M, Boys, J, Buckley, E, Campo, M, Carlton, L, Connelly, A, Conway, B, Cresp, D, Dimitri, H, Dixon, S, Dolman, M, Duroux, M, Eskandari, M, Eslick, R, Ferreira-Jardim, A, Fetahovic, T, Fitzpatrick, D, Geraghty, R, Gibbs, J, Grabek, T, Modi, M, Hayes, K, Hegde, M, Hesketh, L, Hoffmann, B, Johnson, K, Juergens, C, Kassam, I, Lawlor, V, Lehman, M, Lehman, S, Leung, D, Mackay, S, Mackenzie, M, Mccarthy, C, Mcintosh, C, Mckeon, L, Morrison, H, Mussap, C, Myers, J, Nagalingam, V, Oldfield, G, O'May, V, Palmer, J, Parsons, L, Patching, K, Patching, T, Paul, V, Plotz, M, Preston, S, Rashad, H, Ratcliffe, M, Raynes, S, Rose, J, Sanders, L, Seremetkoska, M, Setio, H, Shone, S, Shrestha, P, Singh, C, Singleton, C, Stoyanov, N, Sutcliffe, S, Swaraj, K, Tarrant, J, Thompson, S, Tsay, I, Vorster, M, Waldman, A, Wallis, L, Wilford, E, Wong, K, Luton, R, Gupta, M, Pandey, A, Cheung, S, Leader, R, Beaudry, P, Ayala-Paredes, F, Berlingieri, J, Heath, J, Poirier, G, Du Preez, M, Nadeau, R, Dresser, G, Dhillon, R, Hruczkowski, T, Schweitzer, B, Coutu, B, Angaran, P, Macdonald, P, Vizel, S, Fikry, S, Parkash, R, Lavoie, A, Cha, J, Ramjattan, B, Bonet, J, Ahmad, K, Aro, L, Aves, T, Beaudry, K, Bergeron, C, Bigcanoe, J, Bignell, N, Breakwell, L, Burke, E, Carroll, L, Clarke, B, Cleveland, T, Daheb, S, Dehghani, P, Denis, I, Djaidani, Z, Dorian, P, Douglass, S, Dunnigan, J, Ewert, A, Farquhar, D, Fearon, A, Ferleyko, L, Fournier, D, Fox, B, Grenier, M, Gulliver, W, Haveman, K, Hines, C, Hines, K, Jackson, A, Jean, C, Jethoo, G, Kahlon, R, Kelly, S, Kim, R, Korley, V, Kornder, J, Kwan, L, Largy, J, Lewis, C, Lewis, S, Mangat, I, Moor, R, Navratil, J, Neas, I, Otis, J, Otis, R, Pandey, M, Petrie, F, Pinter, A, Raines, M, Roberts, P, Robinson, M, Sas, G, Schulman, S, Snell, L, Spearson, S, Stevenson, J, Trahey, T, Wright, D, El-Aziz, A, Seif, S, El Din, M, El Etriby, S, Elbahry, A, El-Etreby, A, Elkhadem, M, Katta, A, Khairy, T, Mowafy, A, Nawar, M, Ohanissian, A, Reda, A, Reda, M, Salem, H, Sami, N, Samir, S, Setiha, M, Sobhy, M, Soliman, A, Taha, N, Tawfik, M, Zaatout, E, Kettles, D, Bayat, J, Siebert, H, Horak, A, Kelfkens, Y, Garda, R, Pillay, T, Guerra, M, van Zyl, L, Theron, H, Murray, A, Louw, R, Greyling, D, Mntla, P, Ueckermann, V, Loghdey, R, Ismail, S, Ahmed, F, Engelbrecht, J, Ramdass, A, Maharajh, S, Oosthuysen, W, Angel, G, Bester, C, Booysen, M, Boshoff, C, Cannon, C, Cassimjee, S, Chami, C, Conway, G, Davids, A, de Meyer, L, Du Plessis, G, Ellis, T, Henley, L, Karsten, M, Loyd, E, Marks, J, Mavhusa, L, Mostert, M, Page, A, Rikhotso, L, Salie, M, Sasto, J, Shaik, F, Skein, A, Smith, L, Tarr, G, Tau, T, van Zyl, F, Yousef, G, Agrawal, A, Nathani, M, Ibrahim, M, Esheiba, E, Singh, R, Naguib, A, Abu-Mahfouz, M, Al Omairi, M, Al Naeemi, A, Maruthanayagam, R, Bazargani, N, Wassef, A, Gupta, R, Khan, M, Subbaraman, B, Abdul, A, Al Mulla, A, El Bardisy, S, Haridas, P, Jadhav, S, Magdaluyo, K, Makdad, M, Maqsood, I, Mohamed, R, Sharma, N, Sharma, R, Thanzeel, M, Canosa, R, Rama, P, Blumberg, E, Garcia, J, Mullen, P, Wilson, V, Quick, A, Ferrick, K, Kutayli, W, Cox, M, Franco, M, Falkowski, S, Mendelson, R, Williams, M, Miller, S, Beach, S, Alfieri, A, Gutowski, T, Haque, I, Reddy, R, Ahmed, W, Delafontaine, P, Diercks, D, Theodoro, D, Remmel, K, Alberts, M, Ison, R, Noveck, H, Duffy, P, Pitta, S, Nishijima, D, Treasure, C, Asafu-Adjaye, N, Ball, K, Bartlett, M, Bentley, M, Bowers, S, Brown, A, Browne, A, Cameron-Watts, J, Canova, M, Cassidy, D, Cervellione, K, Congal, S, Depauw, J, Dickerson, A, Eley, M, Evans, L, Felpel, S, Ferdinand, K, Fielder, D, Gentry, P, Haideri, A, Hakimi, F, Harbour, T, Hartranft, E, Hawkins, B, Headlee, M, Henson, L, Herrick, C, Hicks, T, Jasinski, S, Jones, A, Jones, L, Jones, P, Karl, S, Keeling, M, Kerr, J, Knowles, P, Langdon, J, Lay, M, Lee, J, Lincoln, T, Malone, E, Merliss, A, Merritt, D, Minardo, J, Mooso, B, Orosco, C, Palumbo, V, Parker, M, Parrott, T, Paserchia, S, Pearl, G, Peterson, J, Pickelsimer, N, Purcell, T, Raynor, J, Raziano, S, Richard, C, Richardson, T, Robertson, C, Sage, A, Sanghera, T, Shaw, P, Shoemaker, J, Smith, K, Stephanie, B, Thatcher, A, Theobald, H, Thompson, N, Treasure, L, Tripti, T, Verdi, C, and Worthy, V
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Registrie ,Male ,Acute coronary syndrome ,medicine.medical_specialty ,Vitamin K ,medicine.drug_class ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,Administration, Oral ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Registries ,Prospective cohort study ,Stroke ,Aged ,Fibrillation ,business.industry ,Platelet Aggregation Inhibitor ,Anticoagulant ,Anticoagulants ,Atrial fibrillation ,medicine.disease ,ddc ,Prospective Studie ,Administration, Oral, Aged, Anticoagulants, Atrial Fibrillation, Female, Humans, Male, Platelet Aggregation Inhibitors, Prospective Studies, Registries, Stroke, Vitamin K ,Platelet aggregation inhibitor ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Platelet Aggregation Inhibitors ,Kidney disease ,Human - Abstract
Contains fulltext : 209489.pdf (Publisher’s version ) (Open Access) INTRODUCTION: A principal aim of the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) was to document changes in treatment practice for patients with newly diagnosed atrial fibrillation during an era when non-vitamin K antagonist oral anticoagulants (NOACs) were becoming more widely adopted. In these analyses, the key factors which determined the choice between NOACs and vitamin K antagonists (VKAs) are explored. METHODS: Logistic least absolute shrinkage and selection operator regression determined predictors of NOAC and VKA use. Data were collected from 24,137 patients who were initiated on AC+/-antiplatelet (AP) therapy (NOAC [51.4%] or VKA [48.6%]) between April 2013 and August 2016. RESULTS: The most significant predictors of AC therapy were country, enrolment year, care setting at diagnosis, AF type, concomitant AP, and kidney disease. Patients enrolled in emergency care or in the outpatient setting were more likely to receive a NOAC than those enrolled in hospital (OR 1.16 [95% CI: 1.04-1.30], OR: 1.15 [95% CI: 1.05-1.25], respectively). NOAC prescribing seemed to be favored in lower-risk groups, namely, patients with paroxysmal AF, normotensive patients, and those with moderate alcohol consumption, but also the elderly and patients with acute coronary syndrome. By contrast, VKAs were preferentially used in patients with permanent AF, moderate to severe kidney disease, heart failure, vascular disease, and diabetes and with concomitant AP. CONCLUSION: GARFIELD-AF data highlight marked heterogeneity in stroke prevention strategies globally. Physicians are adopting an individualized approach to stroke prevention where NOACs are favored in patients with a lower stroke risk but also in the elderly and patients with acute coronary syndrome.
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- 2019
47. Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016
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GBD 2016 Lifetime Risk of Stroke Collaborators, Feigin, Valery L, Nguyen, Grant, Cercy, Kelly, Johnson, Catherine O, Alam, Tahiya, Parmar, Priyakumari G, Abajobir, Amanuel A, Abate, Kalkidan H, Abd-Allah, Foad, Abejie, Ayenew N, Abyu, Gebre Y, Ademi, Zanfina, Agarwal, Gina, Ahmed, Muktar B, Akinyemi, Rufus O, Al-Raddadi, Rajaa, Aminde, Leopold N, Amlie-Lefond, Catherine, Ansari, Hossein, Asayesh, Hamid, Asgedom, Solomon W, Atey, Tesfay M, Ayele, Henok T, Banach, Maciej, Banerjee, Amitava, Barac, Aleksandra, Barker-Collo, Suzanne L, Bärnighausen, Till, Barregard, Lars, Basu, Sanjay, Bedi, Neeraj, Behzadifar, Masoud, Béjot, Yannick, Bennett, Derrick A, Bensenor, Isabela M, Berhe, Derbew F, Boneya, Dube J, Brainin, Michael, Campos-Nonato, Ismael R, Caso, Valeria, Castañeda-Orjuela, Carlos A, Rivas, Jacquelin C, Catalá-López, Ferrán, Christensen, Hanne, Criqui, Michael H, Damasceno, Albertino, Dandona, Lalit, Dandona, Rakhi, Davletov, Kairat, de Courten, Barbora, deVeber, Gabrielle, Dokova, Klara, Edessa, Dumessa, Endres, Matthias, Faraon, Emerito JA, Farvid, Maryam S, Fischer, Florian, Foreman, Kyle, Forouzanfar, Mohammad H, Gall, Seana L, Gebrehiwot, Tsegaye T, Geleijnse, Johanna M, Gillum, Richard F, Giroud, Maurice, Goulart, Alessandra C, Gupta, Rahul, Gupta, Rajeev, Hachinski, Vladimir, Hamadeh, Randah R, Hankey, Graeme J, Hareri, Habtamu A, Havmoeller, Rasmus, Hay, Simon I, Hegazy, Mohamed I, Hibstu, Desalegn T, James, Spencer L, Jeemon, Panniyammakal, John, Denny, Jonas, Jost B, Jóźwiak, Jacek, Kalani, Rizwan, Kandel, Amit, Kasaeian, Amir, Kengne, Andre P, Khader, Yousef S, Khan, Abdur R, Khang, Young-Ho, Khubchandani, Jagdish, Kim, Daniel, Kim, Yun J, Kivimaki, Mika, Kokubo, Yoshihiro, Kolte, Dhaval, Kopec, Jacek A, Kosen, Soewarta, Kravchenko, Michael, Krishnamurthi, Rita, Kumar, G Anil, Lafranconi, Alessandra, Lavados, Pablo M, Legesse, Yirga, Li, Yongmei, Liang, Xiaofeng, Lo, Warren D, Lorkowski, Stefan, Lotufo, Paulo A, Loy, Clement T, Mackay, Mark T, Abd El Razek, Hassan Magdy, Mahdavi, Mahdi, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah C, Mamun, Abdullah A, Mantovani, Lorenzo G, Martins, Sheila CO, Mate, Kedar K, Mazidi, Mohsen, Mehata, Suresh, Meier, Toni, Melaku, Yohannes A, Mendoza, Walter, Mensah, George A, Meretoja, Atte, Mezgebe, Haftay B, Miazgowski, Tomasz, Miller, Ted R, Ibrahim, Norlinah M, Mohammed, Shafiu, Mokdad, Ali H, Moosazadeh, Mahmood, Moran, Andrew E, Musa, Kamarul I, Negoi, Ruxandra I, Nguyen, Minh, Nguyen, Quyen L, Nguyen, Trang H, Tran, Tung T, Nguyen, Thanh T, Anggraini Ningrum, Dina Nur, Norrving, Bo, Noubiap, Jean J, O’Donnell, Martin J, Olagunju, Andrew T, Onuma, Oyere K, Owolabi, Mayowa O, Parsaeian, Mahboubeh, Patton, George C, Piradov, Michael, Pletcher, Martin A, Pourmalek, Farshad, Prakash, V, Qorbani, Mostafa, Rahman, Mahfuzar, Rahman, Muhammad A, Rai, Rajesh K, Ranta, Annemarei, Rawaf, David, Rawaf, Salman, Renzaho, Andre MN, Robinson, Stephen R, Sahathevan, Ramesh, Sahebkar, Amirhossein, Salomon, Joshua A, Santalucia, Paola, Santos, Itamar S, Sartorius, Benn, Schutte, Aletta E, Sepanlou, Sadaf G, Shafieesabet, Azadeh, Shaikh, Masood A, Shamsizadeh, Morteza, Sheth, Kevin N, Sisay, Mekonnen, Shin, Min-Jeong, Shiue, Ivy, Silva, Diego AS, Sobngwi, Eugene, Soljak, Michael, Sorensen, Reed JD, Sposato, Luciano A, Stranges, Saverio, Suliankatchi, Rizwan A, Tabarés-Seisdedos, Rafael, Tanne, David, Nguyen, Cuong Tat, Thakur, JS, Thrift, Amanda G, Tirschwell, David L, Topor-Madry, Roman, Tran, Bach X, Nguyen, Luong T, Truelsen, Thomas, Tsilimparis, Nikolaos, Tyrovolas, Stefanos, Ukwaja, Kingsley N, Uthman, Olalekan A, Varakin, Yuri, Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Vlassov, Vasiliy V, Wang, Wenzhi, Werdecker, Andrea, Wolfe, Charles DA, Xu, Gelin, Yano, Yuichiro, Yonemoto, Naohiro, Yu, Chuanhua, Zaidi, Zoubida, El Sayed Zaki, Maysaa, Zhou, Maigeng, Ziaeian, Boback, Zipkin, Ben, Vos, Theo, Naghavi, Mohsen, Murray, Christopher JL, and Roth, Gregory A
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Risk ,Adult ,Aged, 80 and over ,Male ,Medical And Health Sciences ,Incidence ,Middle Aged ,Global Health ,Global Burden of Disease ,Stroke ,Age Distribution ,GBD 2016 Lifetime Risk of Stroke Collaborators ,Socioeconomic Factors ,Cause of Death ,General & Internal Medicine ,Humans ,Female ,Sex Distribution ,Aged - Abstract
BACKGROUND:The lifetime risk of stroke has been calculated in a limited number of selected populations. We sought to estimate the lifetime risk of stroke at the regional, country, and global level using data from a comprehensive study of the prevalence of major diseases. METHODS:We used the Global Burden of Disease (GBD) Study 2016 estimates of stroke incidence and the competing risks of death from any cause other than stroke to calculate the cumulative lifetime risks of first stroke, ischemic stroke, or hemorrhagic stroke among adults 25 years of age or older. Estimates of the lifetime risks in the years 1990 and 2016 were compared. Countries were categorized into quintiles of the sociodemographic index (SDI) used in the GBD Study, and the risks were compared across quintiles. Comparisons were made with the use of point estimates and uncertainty intervals representing the 2.5th and 97.5th percentiles around the estimate. RESULTS:The estimated global lifetime risk of stroke from the age of 25 years onward was 24.9% (95% uncertainty interval, 23.5 to 26.2); the risk among men was 24.7% (95% uncertainty interval, 23.3 to 26.0), and the risk among women was 25.1% (95% uncertainty interval, 23.7 to 26.5). The risk of ischemic stroke was 18.3%, and the risk of hemorrhagic stroke was 8.2%. In high-SDI, high-middle-SDI, and low-SDI countries, the estimated lifetime risk of stroke was 23.5%, 31.1% (highest risk), and 13.2% (lowest risk), respectively; the 95% uncertainty intervals did not overlap between these categories. The highest estimated lifetime risks of stroke according to GBD region were in East Asia (38.8%), Central Europe (31.7%), and Eastern Europe (31.6%), and the lowest risk was in eastern sub-Saharan Africa (11.8%). The mean global lifetime risk of stroke increased from 22.8% in 1990 to 24.9% in 2016, a relative increase of 8.9% (95% uncertainty interval, 6.2 to 11.5); the competing risk of death from any cause other than stroke was considered in this calculation. CONCLUSIONS:In 2016, the global lifetime risk of stroke from the age of 25 years onward was approximately 25% among both men and women. There was geographic variation in the lifetime risk of stroke, with the highest risks in East Asia, Central Europe, and Eastern Europe. (Funded by the Bill and Melinda Gates Foundation.).
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- 2018
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48. XALIA-LEA: An observational study of venous thromboembolism treatment with rivaroxaban and standard anticoagulation in the Asia-Pacific, Eastern Europe, the Middle East, Africa and Latin America
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Kreutz, R, Mantovani, L, Haas, S, Monje, D, Schneider, J, Bugge, J, Gebel, M, Tamm, M, Ageno, W, Turpie, A, Kreutz, Reinhold, Mantovani, Lorenzo G., Haas, Sylvia, Monje, Danja, Schneider, Jonas, Bugge, Jörg-Peter, Gebel, Martin, Tamm, Miriam, Ageno, Walter, Turpie, Alexander G. G., Kreutz, R, Mantovani, L, Haas, S, Monje, D, Schneider, J, Bugge, J, Gebel, M, Tamm, M, Ageno, W, Turpie, A, Kreutz, Reinhold, Mantovani, Lorenzo G., Haas, Sylvia, Monje, Danja, Schneider, Jonas, Bugge, Jörg-Peter, Gebel, Martin, Tamm, Miriam, Ageno, Walter, and Turpie, Alexander G. G.
- Abstract
Introduction: The prospective, non-interventional XALIA study investigated the safety and effectiveness of rivaroxaban and standard anticoagulation for the treatment of deep vein thrombosis (DVT). XALIA-LEA was conducted in regions not included in XALIA (Latin America, Eastern Europe, the Middle East, Africa, and the Asia-Pacific), and enrolled patients with isolated pulmonary embolism (PE). Materials and methods: Adult patients with acute venous thromboembolism (VTE) indicated for ≥3 months' anticoagulant treatment were eligible; treatment strategies were at the physician's discretion. Patients receiving rivaroxaban or standard anticoagulation (unfractionated or low-molecular weight heparin/fondaparinux alone or overlapping with and followed by a vitamin K antagonist [VKA]) were included in the safety analysis. “Early switchers” to rivaroxaban (i.e. after receiving heparin/fondaparinux for >2–14 days and/or a VKA for 1–14 days) were not included in the safety analysis set. Results: Of the 1972 eligible patients, 1285 received rivaroxaban, 402 received standard anticoagulation, and 285 were early switchers. Most patients who received rivaroxaban were appropriately selected, received the correct dosing schedule, reported few adverse effects. Outcomes were similar to previously published results, with rivaroxaban associated with a low rate of major bleeding (1.6%), recurrent VTE (1.4%) and all-cause mortality (2.3%). Including early switchers, relatively fewer patients with index isolated PE received rivaroxaban (14.4%) versus standard anticoagulation therapy (20.9%). Some regional variations and differences in outcomes by VTE subtype were apparent with standard anticoagulation treatment. Conclusion: XALIA-LEA reaffirms the safety and effectiveness of rivaroxaban for VTE treatment for countries not included in XALIA.
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- 2019
49. Predictors of NOAC versus VKA use for stroke prevention in patients with newly diagnosed atrial fibrillation: Results from GARFIELD-AF
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Haas, Sylvia, Camm, A John, Bassand, Jean-Pierre, Angchaisuksiri, Pantep, Cools, Frank, Corbalan, Ramon, Gibbs, Harry, Jacobson, Barry, Koretsune, Yukihiro, Mantovani, Lorenzo G, Misselwitz, Frank, Panchenko, Elizaveta, Ragy, Hany Ibrahim, Stepinska, Janina, Turpie, Alexander Gg, Sawhney, Jitendra Ps, Steffel, Jan, Lim, Toon Wei, Pieper, Karen S, Virdone, Saverio, Verheugt, Freek Wa, Kakkar, Ajay K, GARFIELD-AF Investigators, Haas, Sylvia, Camm, A John, Bassand, Jean-Pierre, Angchaisuksiri, Pantep, Cools, Frank, Corbalan, Ramon, Gibbs, Harry, Jacobson, Barry, Koretsune, Yukihiro, Mantovani, Lorenzo G, Misselwitz, Frank, Panchenko, Elizaveta, Ragy, Hany Ibrahim, Stepinska, Janina, Turpie, Alexander Gg, Sawhney, Jitendra Ps, Steffel, Jan, Lim, Toon Wei, Pieper, Karen S, Virdone, Saverio, Verheugt, Freek Wa, Kakkar, Ajay K, and GARFIELD-AF Investigators
- Abstract
INTRODUCTION A principal aim of the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) was to document changes in treatment practice for patients with newly diagnosed atrial fibrillation during an era when non-vitamin K antagonist oral anticoagulants (NOACs) were becoming more widely adopted. In these analyses, the key factors which determined the choice between NOACs and vitamin K antagonists (VKAs) are explored. METHODS Logistic least absolute shrinkage and selection operator regression determined predictors of NOAC and VKA use. Data were collected from 24,137 patients who were initiated on AC ± antiplatelet (AP) therapy (NOAC [51.4%] or VKA [48.6%]) between April 2013 and August 2016. RESULTS The most significant predictors of AC therapy were country, enrolment year, care setting at diagnosis, AF type, concomitant AP, and kidney disease. Patients enrolled in emergency care or in the outpatient setting were more likely to receive a NOAC than those enrolled in hospital (OR 1.16 [95% CI: 1.04-1.30], OR: 1.15 [95% CI: 1.05-1.25], respectively). NOAC prescribing seemed to be favored in lower-risk groups, namely, patients with paroxysmal AF, normotensive patients, and those with moderate alcohol consumption, but also the elderly and patients with acute coronary syndrome. By contrast, VKAs were preferentially used in patients with permanent AF, moderate to severe kidney disease, heart failure, vascular disease, and diabetes and with concomitant AP. CONCLUSION GARFIELD-AF data highlight marked heterogeneity in stroke prevention strategies globally. Physicians are adopting an individualized approach to stroke prevention where NOACs are favored in patients with a lower stroke risk but also in the elderly and patients with acute coronary syndrome.
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- 2019
50. Early risks of death, stroke/systemic embolism, and major bleeding in patients with newly diagnosed atrial fibrillation
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Bassand, J, Virdone, S, Goldhaber, S, Camm, A, Fitzmaurice, D, Fox, K, Goto, S, Haas, S, Hacke, W, Kayani, G, Mantovani, L, Misselwitz, F, Pieper, K, Turpie, A, van Eickels, M, Verheugt, F, Kakkar, A, Bassand, Jean-Pierre, Virdone, Saverio, Goldhaber, Samuel Z., Camm, A John, Fitzmaurice, David A., Fox, Keith A A, Goto, Shinya, Haas, Sylvia, Hacke, Werner, Kayani, Gloria, Mantovani, Lorenzo G., Misselwitz, Frank, Pieper, Karen S., Turpie, Alexander G G, van Eickels, Martin, Verheugt, Freek W A, Kakkar, Ajay K., Bassand, J, Virdone, S, Goldhaber, S, Camm, A, Fitzmaurice, D, Fox, K, Goto, S, Haas, S, Hacke, W, Kayani, G, Mantovani, L, Misselwitz, F, Pieper, K, Turpie, A, van Eickels, M, Verheugt, F, Kakkar, A, Bassand, Jean-Pierre, Virdone, Saverio, Goldhaber, Samuel Z., Camm, A John, Fitzmaurice, David A., Fox, Keith A A, Goto, Shinya, Haas, Sylvia, Hacke, Werner, Kayani, Gloria, Mantovani, Lorenzo G., Misselwitz, Frank, Pieper, Karen S., Turpie, Alexander G G, van Eickels, Martin, Verheugt, Freek W A, and Kakkar, Ajay K.
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BACKGROUND: Atrial fibrillation is associated with increased risks of death, stroke/systemic embolism, and bleeding (incurred by antithrombotic therapy), which may occur early after diagnosis. METHODS: We assessed the risk of early events (death, stroke/systemic embolism, and major bleeding) over 12 months and their relation to the time after diagnosis of atrial fibrillation in 52014 patients prospectively enrolled in the GARFIELD-AF registry (Global Anticoagulant Registry in the FIELD–Atrial Fibrillation) between March 2010 and August 2016. RESULTS: Over 12 months, 2140 patients died (mortality rate, 4.3; 95% CI, 4.2–4.5 per 100 person-years), of whom 288 (13.5%) died in the first month (6.8; 95% CI, 6.1–7.6). Over 12 months, 657 patients had a stroke/systemic embolism (1.3; 95% CI, 1.2–1.4) and 411 had a major bleeding (0.8; 95% CI, 0.8–0.9). During the first month, the rates (per 100 person-years) of stroke/systemic embolism and major bleed were 2.3 (95% CI, 1.9–2.8) and 1.5 (95% CI, 1.2–1.9), respectively. The elevated 1-month mortality rate was mostly attributable to cardiovascular mortality (3.5; 95% CI, 3.0–4.1), in particular, heart failure, sudden death, and acute coronary syndromes (1.0 [95% CI, 0.8–1.4], 0.6 [95% CI, 0.4–0.8], and 0.5 [95% CI, 0.3–0.8], respectively). Age, heart failure, prior stroke, history of cirrhosis, vascular disease, moderate-to-severe kidney disease, diabetes mellitus, and living in North or Latin America were independent predictors of a higher risk of early death, whereas anticoagulation and living in Europe or Asia were independent predictors of a lower risk of early death. A predictive model developed for the 1-month risk of death had a C-statistic of 0.81 (95% CI, 0.78–0.83). CONCLUSIONS: The increased hazard of early events, in particular, cardiovascular mortality, in newly diagnosed atrial fibrillation points to the importance of comprehensive care for such patients and should alert clinicians to detect warning signs of poss
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- 2019
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