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12 results on '"Mangelberger, Doris"'

3. Corrigendum to “Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma” [Neoplasia, Volume 21, Issue 3 (2019) 322–330]

Author

Choi, Jae Eun, Verhaegen, Monique E., Yazdani, Sahr, Malik, Rohit, Harms, Paul W., Mangelberger, Doris, Tien, Jean, Cao, Xuhong, Wang, Yuping, Cieślik, Marcin, Gurkan, Jonathan, Yazdani, Mishaal, Jing, Xiaojun, Juckette, Kristin, Su, Fengyun, Wang, Rui, Zhou, Bing, Apel, Ingrid J., Wang, Shaomeng, Dlugosz, Andrzej A., and Chinnaiyan, Arul M.

Published
2024
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8. Hedgehog‐EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour‐initiating pancreatic cancer cells

Author

Eberl, Markus, Klingler, Stefan, Mangelberger, Doris, Loipetzberger, Andrea, Damhofer, Helene, Zoidl, Kerstin, Schnidar, Harald, Hache, Hendrik, Bauer, Hans‐Christian, Solca, Flavio, Hauser‐Kronberger, Cornelia, Ermilov, Alexandre N., Verhaegen, Monique E., Bichakjian, Christopher K., Dlugosz, Andrzej A., Nietfeld, Wilfried, Sibilia, Maria, Lehrach, Hans, Wierling, Christoph, and Aberger, Fritz

Published
2012
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10. International Journal of Cancer / Synergistic crosstalk of hedgehog and interleukin6 signaling drives growth of basal cell carcinoma

Author

Sternberg, Christina, Gruber, Wolfgang, Eberl, Markus, Tesanovic, Suzana, Stadler, Manuela, Elmer, Dominik P., Schlederer, Michaela, Grund, Sandra, Roos, Simone, Wolff, Florian, Kaur, Supreet, Mangelberger, Doris, Lehrach, Hans, Hache, Hendrik, Wierling, Christoph, Laimer, Josef, Lackner, Peter, Wiederstein, Markus, Kasper, Maria, Risch, Angela, Petzelbauer, Peter, Moriggl, Richard, Kenner, Lukas, and Aberger, Fritz

Subjects
animal structures, integumentary system, basal cell carcinoma, hedgehog, GLI signaling, STAT transcription factors, skin and connective tissue diseases, GLI transcription factors, interleukin6 signaling
Abstract

Persistent activation of hedgehog (HH)/GLI signaling accounts for the development of basal cell carcinoma (BCC), a very frequent nonmelanoma skin cancer with rising incidence. Targeting HH/GLI signaling by approved pathway inhibitors can provide significant therapeutic benefit to BCC patients. However, limited response rates, development of drug resistance, and severe side effects of HH pathway inhibitors call for improved treatment strategies such as rational combination therapies simultaneously inhibiting HH/GLI and cooperative signals promoting the oncogenic activity of HH/GLI. In this study, we identified the interleukin6 (IL6) pathway as a novel synergistic signal promoting oncogenic HH/GLI via STAT3 activation. Mechanistically, we provide evidence that signal integration of IL6 and HH/GLI occurs at the level of cisregulatory sequences by cobinding of GLI and STAT3 to common HHIL6 target gene promoters. Genetic inactivation of Il6 signaling in a mouse model of BCC significantly reduced in vivo tumor growth by interfering with HH/GLIdriven BCC proliferation. Our genetic and pharmacologic data suggest that combinatorial HHIL6 pathway blockade is a promising approach to efficiently arrest cancer growth in BCC patients. (VLID)3012344

Published
2018
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12. Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway

Author

Schnidar, Harald, primary, Eberl, Markus, additional, Klingler, Stefan, additional, Mangelberger, Doris, additional, Kasper, Maria, additional, Hauser-Kronberger, Cornelia, additional, Regl, Gerhard, additional, Kroismayr, Renate, additional, Moriggl, Richard, additional, Sibilia, Maria, additional, and Aberger, Fritz, additional

Published
2009
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