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7 results on '"Makalish, Tatyana P."'

2. Oligonucleotide Insecticides for Green Agriculture: Regulatory Role of Contact DNA in Plant–Insect Interactions

Author

Oberemok, Volodymyr V., primary, Useinov, Refat Z., additional, Skorokhod, Oleksii A., additional, Gal’chinsky, Nikita V., additional, Novikov, Ilya A., additional, Makalish, Tatyana P., additional, Yatskova, Ekaterina V., additional, Sharmagiy, Alexander K., additional, Golovkin, Ilya O., additional, Gninenko, Yuri I., additional, Puzanova, Yelizaveta V., additional, Andreeva, Oksana A., additional, Alieva, Edie E., additional, Eken, Emre, additional, Laikova, Kateryna V., additional, and Plugatar, Yuri V., additional

Published
2022
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3. Immunohistochemical Expression of VDR in Myocardium: Postmortem Evaluation of COVID-19 Patients

Author

Kriventsov, Maxim A., primary, Yermola, Yulianna A., additional, Davydova, Alexandra A., additional, Beketov, Alexey A., additional, Makalish, Tatyana P., additional, Zyablitskaya, Evgeniya Yu., additional, Geraschenko, Alina V., additional, Kubyshkin, Anatoly V., additional, Galyshevskaya, Anna A., additional, and Zausalina, Anastasia I., additional

Published
2022
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4. Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression

Author

Makalish, Tatyana P., primary, Golovkin, Ilya O., additional, Oberemok, Volodymyr V., additional, Laikova, Kateryna V., additional, Temirova, Zenure Z., additional, Serdyukova, Olesya A., additional, Novikov, Ilya A., additional, Rosovskyi, Roman A., additional, Gordienko, Andrey I., additional, Zyablitskaya, Evgeniya Yu., additional, Gafarova, Elvina A., additional, Yurchenko, Kseniya A., additional, Fomochkina, Iryna I., additional, and Kubyshkin, Anatoly V., additional

Published
2021
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7. Adjuvant Oligonucleotide Vaccine Increases Survival and Improves Lung Tissue Condition of B6.Cg-Tg (K18-ACE2)2 Transgenic Mice.

Author

Oberemok, Volodymyr V., Laikova, Kateryna V., Yurchenko, Kseniya A., Novikov, Ilya A., Makalish, Tatyana P., Kubyshkin, Anatolii V., Andreeva, Oksana A., and Bilyk, Anastasiya I.

Subjects
*TRANSGENIC mice, *VACCINES, *LUNGS, *NATURAL immunity, *INFECTION prevention
Abstract

The main problem in creating anti-coronavirus vaccines that target mainly proteins of the outer membrane of the virus is the rapid variability in the RNA genome of the pathogen that encodes these proteins. In addition, the introduction of technologies that can affordably and quickly produce flexible vaccine formulas that easily adapt to the emergence of new subtypes of SARS-CoV-2 is required. Universal adjuvant oligonucleotide vaccines based on conserved regions of the SARS-CoV-2 genome can take into account the dynamics of rapid changes in the virus genome, as well as be easily synthesized on automatic DNA synthesizers in large quantities in a short time. In this brief report, the effectiveness of four phosphorothioate constructs of the La-S-so-type adjuvant oligonucleotide vaccine is evaluated on B6.Cg-Tg (K18-ACE2)2 transgenic mice for the first time. In our primary trials, the oligonucleotide vaccine increased the survival rate of animals infected with SARS-CoV-2 and also reduced the destructive effects of the virus on the lung tissue of mice, activating both their innate and adaptive immunity. The obtained results show that the development of adjuvant oligonucleotide vaccine constructs of the La-S-so type is an affordable and efficient platform for the prevention of coronavirus infections, including those caused by SARS-CoV-2. [ABSTRACT FROM AUTHOR]

Published
2023
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