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3. The Epidemiology of Anal Human Papillomavirus (HPV) in HIV-Positive and HIV-Negative Women and Men: A Ten-Year Retrospective Observational Study in Rome (Italy).

Author

Fracella, Matteo, Oliveto, Giuseppe, Roberto, Piergiorgio, Cinti, Lilia, Gentile, Massimo, Coratti, Eleonora, D'Ettorre, Gabriella, Cavallari, Eugenio Nelson, Romano, Francesco, Santinelli, Letizia, Maddaloni, Luca, Frasca, Federica, Scagnolari, Carolina, Antonelli, Guido, and Pierangeli, Alessandra

Subjects
PAPILLOMAVIRUSES, HUMAN papillomavirus, HIV-positive women, ANAL cancer, HIV-positive men, SCIENTIFIC observation
Abstract

Human papillomaviruses (HPVs) commonly infect the anogenital mucosa; most infections are transient, but a fraction of those caused by high-risk (HR) types persist and may lead to anogenital cancer. The epidemiology of HPV genotypes in anal infections in groups at different risk for anal cancer has not been well described in Italy. This retrospective study reports the results of HPV DNA testing and complete genotyping performed on anal swabs from 691 female and male patients attending proctology clinics in Rome during 2012–2021; one-third had repeated testing. Cumulative HPV positivity in 1212 anal swabs was approximately 60%, was not age related, and showed an increasing trend over the study period. HPV rates differed significantly by sex and HIV status: HIV-negative women had the lowest (43.6%) and HIV-positive men the highest (83.5%) HPV prevalence. HIV-positive men had more oncogenic HPV genotypes detected, more multiple infections, and the highest frequency of persistent infections. Two-thirds of all infections were vaccine-preventable. This study found that anal HPV infection rates are still elevated and even increasing in groups at low and high risk of developing anal cancer. Prevention programs need to be improved to reduce rates of anal infection in young women and men. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Differential expression of Type I interferon and inflammatory genes in SARS‐CoV‐2‐infected patients treated with monoclonal antibodies

Author

Maddaloni, Luca, primary, Santinelli, Letizia, additional, Bugani, Ginevra, additional, Cacciola, Elio G., additional, Lazzaro, Alessandro, additional, Lofaro, Chiara M., additional, Caiazzo, Sara, additional, Frasca, Federica, additional, Fracella, Matteo, additional, Ajassa, Camilla, additional, Leanza, Cristiana, additional, Napoli, Anna, additional, Cinti, Lilia, additional, Gaeta, Aurelia, additional, Antonelli, Guido, additional, Ceccarelli, Giancarlo, additional, Mastroianni, Claudio M., additional, Scagnolari, Carolina, additional, and d'Ettorre, Gabriella, additional

Published
2023
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5. Immune Reconstitution and Safe Metabolic Profile after the Switch to Bictegravir/Emtricitabine/Tenofovir Alafenamide Fumarate among Virologically Controlled PLWH: A 96 Week Update from the BICTEL Cohort

Author

Lazzaro, Alessandro, primary, Bianchini, Diana, additional, Gentilini Cacciola, Elio, additional, Mezzaroma, Ivano, additional, Falciano, Mario, additional, Andreoni, Carolina, additional, Fimiani, Caterina, additional, Santinelli, Letizia, additional, Maddaloni, Luca, additional, Bugani, Ginevra, additional, Ceccarelli, Giancarlo, additional, Mastroianni, Claudio Maria, additional, and d’Ettorre, Gabriella, additional

Published
2023
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6. Cellular Immune Profiling of Lung and Blood Compartments in Patients with SARS-CoV-2 Infection

Author

Santinelli, Letizia, primary, Lazzaro, Alessandro, additional, Sciarra, Francesca, additional, Maddaloni, Luca, additional, Frasca, Federica, additional, Fracella, Matteo, additional, Moretti, Sonia, additional, Borsetti, Alessandra, additional, Bugani, Ginevra, additional, Alessandri, Francesco, additional, Zullino, Veronica, additional, Ruberto, Franco, additional, Pugliese, Francesco, additional, Sorrentino, Leonardo, additional, Gianfrilli, Daniele, additional, Isidori, Andrea, additional, Venneri, Mary Anna, additional, Mastroianni, Claudio M., additional, Ceccarelli, Giancarlo, additional, and d’Ettorre, Gabriella, additional

Published
2023
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7. Alterations in the Expression of IFN Lambda, IFN Gamma and Toll-like Receptors in Severe COVID-19 Patients

Author

Sorrentino, Leonardo, primary, Fracella, Matteo, additional, Frasca, Federica, additional, D’Auria, Alessandra, additional, Santinelli, Letizia, additional, Maddaloni, Luca, additional, Bugani, Ginevra, additional, Bitossi, Camilla, additional, Gentile, Massimo, additional, Ceccarelli, Giancarlo, additional, Turriziani, Ombretta, additional, Mastroianni, Claudio Maria, additional, Antonelli, Guido, additional, d’Ettorre, Gabriella, additional, Pierangeli, Alessandra, additional, and Scagnolari, Carolina, additional

Published
2023
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8. Exploiting Bacteria for Improving Hypoxemia of COVID-19 Patients

Author

Trinchieri, Vito, primary, Marazzato, Massimiliano, additional, Ceccarelli, Giancarlo, additional, Lombardi, Francesca, additional, Piccirilli, Alessandra, additional, Santinelli, Letizia, additional, Maddaloni, Luca, additional, Vassalini, Paolo, additional, Mastroianni, Claudio Maria, additional, and d’Ettorre, Gabriella, additional

Published
2022
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