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2. Life course social mobility and risk of upper aerodigestive tract cancer in men

Author

Schmeisser, N., Conway, D. I., McKinney, P. A., McMahon, A. D., Pohlabeln, H., Marron, M., Benhamou, S., Bouchardy, C., Macfarlane, G. J., Macfarlane, T. V., Lagiou, P., Lagiou, A., Bencko, V., Holcátová, I., Merletti, F., Richiardi, L., Kjaerheim, K., Agudo, A., Talamini, R., Polesel, J., Canova, C., Simonato, L., Lowry, R., Znaor, A., Healy, C., McCarten, B. E., Hashibe, M., Brennan, P., and Ahrens, W.

Published
2010

10. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Author

Bravi, F, Lee, Y, Hashibe, M, Boffetta, P, Conway, D, Ferraroni, M, La Vecchia, C, Edefonti, V, Agudo, A, Ahrens, W, Benhamou, S, Boccia, S, Brennan, P, Brenner, H, Cadoni, G, Canova, C, Chen, C, Chuang, S, Curado, M, Dal Maso, L, Daudt, A, D'Souza, G, Fabianova, E, Fernandez, L, Franceschi, S, Garavello, W, Gillison, M, Gross, N, Hayes, R, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, R, Lagiou, P, Lazarus, P, Levi, F, Li, G, Lissowska, J, Luce, D, Macfarlane, G, Mates, D, Matsuo, K, Mcclean, M, Menezes, A, Menvielle, G, Morgenstern, H, Moyses, R, Moysich, K, Muscat, J, Negri, E, Olshan, A, Pandics, T, Polesel, J, Purdue, M, Radoi, L, Ramroth, H, Richiardi, L, Schantz, S, Schwartz, S, Serraino, D, Shangina, O, Smith, E, Sturgis, E, Swiatkowska, B, Thomson, P, Toporcov, T, Vaughan, T, Vilensky, M, Winn, D, Wunsch-Filho, V, Yu, G, Zevallos, J, Zhang, Z, Zheng, T, Znaor, A, Bravi F., Lee Y. -C. A., Hashibe M., Boffetta P., Conway D. I., Ferraroni M., La Vecchia C., Edefonti V., Agudo A., Ahrens W., Benhamou S., Boccia S., Brennan P., Brenner H., Cadoni G., Canova C., Chen C., Chuang S. -C., Curado M. P., Dal Maso L., Daudt A. W., D'Souza G., Fabianova E., Fernandez L., Franceschi S., Garavello W., Gillison M., Gross N. D., Hayes R. B., Healy C., Herrero R., Holcatova I., Kelsey K., Kjaerheim K., Koifman R., Lagiou P., Lazarus P., Levi F., Li G., Lissowska J., Luce D., Macfarlane G. J., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Morgenstern H., Moyses R. A., Moysich K., Muscat J., Negri E., Olshan A. F., Pandics T., Polesel J., Purdue M. P., Radoi L., Ramroth H., Richiardi L., Schantz S., Schwartz S. M., Serraino D., Shangina O., Smith E., Sturgis E. M., Swiatkowska B., Thomson P., Toporcov T. N., Vaughan T. L., Vilensky M., Winn D. M., Wunsch-Filho V., Yu G. -P., Zevallos J. P., Zhang Z. -F., Zheng T., Znaor A., Bravi, F, Lee, Y, Hashibe, M, Boffetta, P, Conway, D, Ferraroni, M, La Vecchia, C, Edefonti, V, Agudo, A, Ahrens, W, Benhamou, S, Boccia, S, Brennan, P, Brenner, H, Cadoni, G, Canova, C, Chen, C, Chuang, S, Curado, M, Dal Maso, L, Daudt, A, D'Souza, G, Fabianova, E, Fernandez, L, Franceschi, S, Garavello, W, Gillison, M, Gross, N, Hayes, R, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, R, Lagiou, P, Lazarus, P, Levi, F, Li, G, Lissowska, J, Luce, D, Macfarlane, G, Mates, D, Matsuo, K, Mcclean, M, Menezes, A, Menvielle, G, Morgenstern, H, Moyses, R, Moysich, K, Muscat, J, Negri, E, Olshan, A, Pandics, T, Polesel, J, Purdue, M, Radoi, L, Ramroth, H, Richiardi, L, Schantz, S, Schwartz, S, Serraino, D, Shangina, O, Smith, E, Sturgis, E, Swiatkowska, B, Thomson, P, Toporcov, T, Vaughan, T, Vilensky, M, Winn, D, Wunsch-Filho, V, Yu, G, Zevallos, J, Zhang, Z, Zheng, T, Znaor, A, Bravi F., Lee Y. -C. A., Hashibe M., Boffetta P., Conway D. I., Ferraroni M., La Vecchia C., Edefonti V., Agudo A., Ahrens W., Benhamou S., Boccia S., Brennan P., Brenner H., Cadoni G., Canova C., Chen C., Chuang S. -C., Curado M. P., Dal Maso L., Daudt A. W., D'Souza G., Fabianova E., Fernandez L., Franceschi S., Garavello W., Gillison M., Gross N. D., Hayes R. B., Healy C., Herrero R., Holcatova I., Kelsey K., Kjaerheim K., Koifman R., Lagiou P., Lazarus P., Levi F., Li G., Lissowska J., Luce D., Macfarlane G. J., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Morgenstern H., Moyses R. A., Moysich K., Muscat J., Negri E., Olshan A. F., Pandics T., Polesel J., Purdue M. P., Radoi L., Ramroth H., Richiardi L., Schantz S., Schwartz S. M., Serraino D., Shangina O., Smith E., Sturgis E. M., Swiatkowska B., Thomson P., Toporcov T. N., Vaughan T. L., Vilensky M., Winn D. M., Wunsch-Filho V., Yu G. -P., Zevallos J. P., Zhang Z. -F., Zheng T., and Znaor A.

Abstract

Objective: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview. Results: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively. Conclusions: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies.

Published
2021

11. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Author

Bravi, F., Lee, Y. -C. A., Hashibe, M., Boffetta, Paolo, Conway, D. I., Ferraroni, M., La Vecchia, C., Edefonti, V., Agudo, A., Ahrens, W., Benhamou, S., Boccia, Stefania, Brennan, P., Brenner, H., Cadoni, Gabriella, Canova, C., Chen, Chen, Chuang, S. -C., Curado, M. P., Dal Maso, L., Daudt, A. W., D'Souza, G., Fabianova, E., Fernandez, L., Franceschi, S., Garavello, W., Gillison, M., Gross, N. D., Hayes, R. B., Healy, C., Herrero, R., Holcatova, I., Kelsey, K., Kjaerheim, K., Koifman, R., Lagiou, Pagona, Lazarus, P., Levi, F., Li, G., Lissowska, J., Luce, D., Macfarlane, G. J., Mates, D., Matsuo, K., Mcclean, M., Menezes, A., Menvielle, G., Morgenstern, H., Moyses, R. A., Moysich, K., Muscat, J., Negri, Erica, Olshan, A. F., Pandics, T., Polesel, J., Purdue, M. P., Radoi, L., Ramroth, H., Richiardi, L., Schantz, S., Schwartz, S. M., Serraino, D., Shangina, O., Smith, E., Sturgis, E. M., Swiatkowska, B., Thomson, P., Toporcov, T. N., Vaughan, T. L., Vilensky, M., Winn, D. M., Wunsch-Filho, V., Yu, G. -P., Zevallos, J. P., Zhang, Z. -F., Zheng, T., Znaor, A., Boffetta P., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chen C., Lagiou P., Negri E., Bravi, F., Lee, Y. -C. A., Hashibe, M., Boffetta, Paolo, Conway, D. I., Ferraroni, M., La Vecchia, C., Edefonti, V., Agudo, A., Ahrens, W., Benhamou, S., Boccia, Stefania, Brennan, P., Brenner, H., Cadoni, Gabriella, Canova, C., Chen, Chen, Chuang, S. -C., Curado, M. P., Dal Maso, L., Daudt, A. W., D'Souza, G., Fabianova, E., Fernandez, L., Franceschi, S., Garavello, W., Gillison, M., Gross, N. D., Hayes, R. B., Healy, C., Herrero, R., Holcatova, I., Kelsey, K., Kjaerheim, K., Koifman, R., Lagiou, Pagona, Lazarus, P., Levi, F., Li, G., Lissowska, J., Luce, D., Macfarlane, G. J., Mates, D., Matsuo, K., Mcclean, M., Menezes, A., Menvielle, G., Morgenstern, H., Moyses, R. A., Moysich, K., Muscat, J., Negri, Erica, Olshan, A. F., Pandics, T., Polesel, J., Purdue, M. P., Radoi, L., Ramroth, H., Richiardi, L., Schantz, S., Schwartz, S. M., Serraino, D., Shangina, O., Smith, E., Sturgis, E. M., Swiatkowska, B., Thomson, P., Toporcov, T. N., Vaughan, T. L., Vilensky, M., Winn, D. M., Wunsch-Filho, V., Yu, G. -P., Zevallos, J. P., Zhang, Z. -F., Zheng, T., Znaor, A., Boffetta P., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chen C., Lagiou P., and Negri E.

Abstract

Objective: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview. Results: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively. Conclusions: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies.

Published
2021

13. Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study

Author

Macfarlane, T. V., Macfarlane, G. J., Thakker, N. S., Benhamou, S., Bouchardy, C., Ahrens, W., Pohlabeln, H., Lagiou, P., Lagiou, A., Castellsague, X., Agudo, A., Slamova, A., Plzak, J., Merletti, F., Richiardi, L., Talamini, R., Barzan, L., Kjaerheim, K., Canova, C., Simonato, L., Conway, D. I., McKinney, P. A., Thomson, P., Sloan, P., Znaor, A., Healy, C. M., McCartan, B. E., Marron, M., and Brennan, P.

Published
2012
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24. Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Author

Di Credico, G, Polesel, J, Dal Maso, L, Pauli, F, Torelli, N, Luce, D, Radoi, L, Matsuo, K, Serraino, D, Brennan, P, Holcatova, I, Ahrens, W, Lagiou, P, Canova, C, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, G, Thomson, P, Agudo, A, Znaor, A, Franceschi, S, Herrero, R, Toporcov, T, Moyses, R, Muscat, J, Negri, E, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Olshan, A, Zevallos, J, Sturgis, E, Li, G, Levi, F, Zhang, Z, Morgenstern, H, Smith, E, Lazarus, P, La Vecchia, C, Garavello, W, Chen, C, Schwartz, S, Zheng, T, Vaughan, T, Kelsey, K, Mcclean, M, Benhamou, S, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Chuang, S, Boffetta, P, Hashibe, M, Yuan-Chin, A, Edefonti, V, Di Credico G., Polesel J., Dal Maso L., Pauli F., Torelli N., Luce D., Radoi L., Matsuo K., Serraino D., Brennan P., Holcatova I., Ahrens W., Lagiou P., Canova C., Richiardi L., Healy C. M., Kjaerheim K., Conway D. I., Macfarlane G. J., Thomson P., Agudo A., Znaor A., Franceschi S., Herrero R., Toporcov T. N., Moyses R. A., Muscat J., Negri E., Vilensky M., Fernandez L., Curado M. P., Menezes A., Daudt A. W., Koifman R., Wunsch-Filho V., Olshan A. F., Zevallos J. P., Sturgis E. M., Li G., Levi F., Zhang Z. -F., Morgenstern H., Smith E., Lazarus P., La Vecchia C., Garavello W., Chen C., Schwartz S. M., Zheng T., Vaughan T. L., Kelsey K., McClean M., Benhamou S., Hayes R. B., Purdue M. P., Gillison M., Schantz S., Yu G. -P., Chuang S. -C., Boffetta P., Hashibe M., Yuan-Chin A. L., Edefonti V., Di Credico, G, Polesel, J, Dal Maso, L, Pauli, F, Torelli, N, Luce, D, Radoi, L, Matsuo, K, Serraino, D, Brennan, P, Holcatova, I, Ahrens, W, Lagiou, P, Canova, C, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, G, Thomson, P, Agudo, A, Znaor, A, Franceschi, S, Herrero, R, Toporcov, T, Moyses, R, Muscat, J, Negri, E, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Olshan, A, Zevallos, J, Sturgis, E, Li, G, Levi, F, Zhang, Z, Morgenstern, H, Smith, E, Lazarus, P, La Vecchia, C, Garavello, W, Chen, C, Schwartz, S, Zheng, T, Vaughan, T, Kelsey, K, Mcclean, M, Benhamou, S, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Chuang, S, Boffetta, P, Hashibe, M, Yuan-Chin, A, Edefonti, V, Di Credico G., Polesel J., Dal Maso L., Pauli F., Torelli N., Luce D., Radoi L., Matsuo K., Serraino D., Brennan P., Holcatova I., Ahrens W., Lagiou P., Canova C., Richiardi L., Healy C. M., Kjaerheim K., Conway D. I., Macfarlane G. J., Thomson P., Agudo A., Znaor A., Franceschi S., Herrero R., Toporcov T. N., Moyses R. A., Muscat J., Negri E., Vilensky M., Fernandez L., Curado M. P., Menezes A., Daudt A. W., Koifman R., Wunsch-Filho V., Olshan A. F., Zevallos J. P., Sturgis E. M., Li G., Levi F., Zhang Z. -F., Morgenstern H., Smith E., Lazarus P., La Vecchia C., Garavello W., Chen C., Schwartz S. M., Zheng T., Vaughan T. L., Kelsey K., McClean M., Benhamou S., Hayes R. B., Purdue M. P., Gillison M., Schantz S., Yu G. -P., Chuang S. -C., Boffetta P., Hashibe M., Yuan-Chin A. L., and Edefonti V.

Abstract

Background: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.

Published
2020

49. Eular Revised Recommendations For The Management Of Fibromyalgia

Author

Macfarlane, G. J., Kronisch, C., Dean, L. E., Atzeni, F., Haeuser, W., Fluss, E., Choy, E., Kosek, E., Amris, K., Branco, J., Dincer, F., Leino-Arjas, P., Longley, K., McCarthy, G. M., Makri, S., Perrot, S., Sarzi-Puttini, P., Taylor, A., Jones, G. T., and Çocuk Sağlığı ve Hastalıkları

Subjects
Rheumatology
Abstract

Objective The original European League Against Rheumatism recommendations for managing fibromyalgia assessed evidence up to 2005. The paucity of studies meant that most recommendations were ' expert opinion'. Methods A multidisciplinary group from 12 countries assessed evidence with a focus on systematic reviews and meta-analyses concerned with pharmacological/nonpharmacological management for fibromyalgia. A review, in May 2015, identified eligible publications and key outcomes assessed were pain, fatigue, sleep and daily functioning. The Grading of Recommendations Assessment, Development and Evaluation system was used for making recommendations. Results 2979 titles were identified: from these 275 full papers were selected for review and 107 reviews (and/or meta-analyses) evaluated as eligible. Based on metaanalyses, the only ' strong for' therapy-based recommendation in the guidelines was exercise. Based on expert opinion, a graduated approach, the following four main stages are suggested underpinned by shared decision-making with patients. Initial management should involve patient education and focus on nonpharmacological therapies. In case of non-response, further therapies (all of which were evaluated as ' weak for' based on meta-analyses) should be tailored to the specific needs of the individual and may involve psychological therapies (for mood disorders and unhelpful coping strategies), pharmacotherapy (for severe pain or sleep disturbance) and/or a multimodal rehabilitation programme (for severe disability). Conclusions These recommendations are underpinned by high-quality reviews and meta-analyses. The size of effect for most treatments is relatively modest. We propose research priorities clarifying who will benefit from specific interventions, their effect in combination and organisation of healthcare systems to optimise outcome.

Published
2017

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