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28 results on '"MacIntosh, C."'

1. Ocean Heat Convergence and North Atlantic Multidecadal Heat Content Variability

Author

Moat, B. I., Sinha, B., Berry, D. I., Drijfhout, S. S., Fraser, N., Hermanson, L., Jones, D. C., Josey, S. A., King, B., Macintosh, C., Megann, A., Oltmanns, M., Sanders, R., Williams, S., Moat, B. I., Sinha, B., Berry, D. I., Drijfhout, S. S., Fraser, N., Hermanson, L., Jones, D. C., Josey, S. A., King, B., Macintosh, C., Megann, A., Oltmanns, M., Sanders, R., and Williams, S.

Abstract

We construct an upper ocean (0–1000 m) North Atlantic heat budget (26°–67°N) for the period 1950–2020 using multiple observational datasets and an eddy-permitting global ocean model. On multidecadal time scales, ocean heat transport convergence controls ocean heat content (OHC) tendency in most regions of the North Atlantic with little role for diffusive processes. In the subpolar North Atlantic (45°–67°N), heat transport convergence is explained by geostrophic currents, whereas ageostrophic currents make a significant contribution in the subtropics (26°–45°N). The geostrophic contribution in all regions is dominated by anomalous advection across the time-mean temperature gradient although other processes make a significant contribution, particularly in the subtropics. The time scale and spatial distribution of the anomalous geostrophic currents are consistent with a simple model of basin-scale thermal Rossby waves propagating westward/northwestward in the subpolar gyre, and multidecadal variations in regional OHC are explained by geostrophic currents periodically coming into alignment with the mean temperature gradient as the Rossby wave passes through. The global ocean model simulation shows that multidecadal variations in the Atlantic meridional overturning circulation are synchronized with the ocean heat transport convergence consistent with modulation of the west–east pressure gradient by the propagating Rossby wave.

Published
2024

2. Ocean heat convergence and North Atlantic multidecadal heat content variability

Author

Moat, B.I., Sinha, B., Berry, D.I., Drijfhout, S.S., Fraser, N., Hermanson, L., Jones, D.C., Josey, S.A., King, B., Macintosh, C., Megann, A., Oltmanns, M., Sanders, R., Williams, S., Moat, B.I., Sinha, B., Berry, D.I., Drijfhout, S.S., Fraser, N., Hermanson, L., Jones, D.C., Josey, S.A., King, B., Macintosh, C., Megann, A., Oltmanns, M., Sanders, R., and Williams, S.

Abstract

We construct an upper ocean (0-1000m) North Atlantic heat budget (26°-67°N) for the period 1950-2020 using multiple observational datasets and an eddy-permitting global ocean model. On multidecadal timescales ocean heat transport convergence controls ocean heat content (OHC) tendency in most regions of the North Atlantic with little role for diffusive processes. In the subpolar North Atlantic (45°N-67°N) heat transport convergence is explained by geostrophic currents whereas ageostrophic currents make a significant contribution in the subtropics (26°N-45°N). The geostrophic contribution in all regions is dominated by anomalous advection across the time-mean temperature gradient although other processes make a significant contribution particularly in the subtropics. The timescale and spatial distribution of the anomalous geostrophic currents are consistent with a simple model of basin scale thermal Rossby waves propagating westwards/northwestwards in the subpolar gyre and multidecadal variations in regional OHC are explained by geostrophic currents periodically coming into alignment with the mean temperature gradient as the Rossby wave passes through. The global ocean model simulation shows that multidecadal variations in the Atlantic Meridional Overturning Circulation are synchronized with the ocean heat transport convergence consistent with modulation of the west-east pressure gradient by the propagating Rossby wave.

Published
2024

4. Cost-Effectiveness of a Multifaceted Podiatry Intervention for the Prevention of Falls in Older People: The REducing Falls with Orthoses and a Multifaceted Podiatry Intervention Trial Findings

Author

Corbacho, B, Cockayne, S, Fairhurst, C, Hewitt, C, Hicks, K, Kenan, A, Lamb, S, MacIntosh, C, Menz, H, Redmond, A, Rodgers, S, Scantlebury, A, Watson, J, Torgerson, D, and on behalf of the REFORM study

Subjects
Male, Aging, medicine.medical_specialty, Cost effectiveness, Cost-Benefit Analysis, Psychological intervention, Foot Orthoses, Rate ratio, law.invention, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Quality of life, law, Intervention (counseling), Humans, Medicine, 030212 general & internal medicine, Podiatry, Aged, business.industry, 030503 health policy & services, England, Cohort, Quality of Life, Physical therapy, Accidental Falls, Female, Geriatrics and Gerontology, 0305 other medical science, business, Ireland
Abstract

Background: Falls are a major cause of morbidity among older people. Multifaceted interventions may be effective in preventing falls and related fractures. Objective: To evaluate the cost-effectiveness alongside the REducing Falls with Orthoses and a Multifaceted podiatry intervention (REFORM) trial. Methods: REFORM was a pragmatic multicentre cohort randomised controlled trial in England and Ireland; 1,010 participants (> 65 years) were randomised to receive either a podiatry intervention (n = 493), including foot and ankle strengthening exercises, foot orthoses, new footwear if required, and a falls prevention leaflet, or usual podiatry treatment plus a falls prevention leaflet (n = 517). Primary outcome: incidence of falls per participant in the 12 months following randomisation. Secondary outcomes: proportion of fallers and quality of life (EQ-5D-3L) which was converted into quality-adjusted life years (QALYs) for each participant. Differences in mean costs and QALYs at 12 months were used to assess the cost-effectiveness of the intervention relative to usual care. Cost-effectiveness analyses were conducted in accordance with National Institute for Health and Clinical Excellence reference case standards, using a regression-based approach with costs expressed in GBP (2015 price). The base case analysis used an intention-to-treat approach on the imputed data set using multiple imputation. Results: There was a small, non-statistically significant reduction in the incidence rate of falls in the intervention group (adjusted incidence rate ratio 0.88, 95% CI 0.73–1.05, p = 0.16). Participants allocated to the intervention group accumulated on average marginally higher QALYs than the usual care participants (mean difference 0.0129, 95% CI –0.0050 to 0.0314). The intervention costs were on average GBP 252 more per participant compared to the usual care participants (95% CI GBP –69 to GBP 589). Incremental cost-effectiveness ratios ranged between GBP 19,494 and GBP 20,593 per QALY gained, below the conventional National Health Service cost-effectiveness thresholds of GBP 20,000 to GBP 30,000 per additional QALY. The probability that the podiatry intervention is cost-effective at a threshold of GBP 30,000 per QALY gained was 0.65. The results were robust to sensitivity analyses. Conclusion: The benefits of the intervention justified the moderate cost. The intervention could be a cost-effective option for falls prevention when compared with usual care in the UK.

Published
2018
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6. Recent observed changes in the North Atlantic climate system with a focus on 2005-2016

Author

Robson, J, Sutton, RT, Archibald, A, Cooper, F, Christensen, M, Grey, LJ, Holliday, NP, Macintosh, C, McMillan, M, Moat, B, Russo, M, Tilling, R, Carslaw, K, Desbruyères, D, Embury, O, Feltham, D, Grosvenor, D, Josey, S, King, B, Lewis, A, McCarthy, GD, Merchant, C, New, AL, O'Reilly, CH, Osprey, SM, Read, K, Scaife, A, Shepherd, A, Sinha, B, Smeed, D, Smith, D, Ridout, A, Woollings, TJ, and Yang, M

Abstract

Major changes are occurring across the North Atlantic climate system, including in the atmosphere, ocean and cryosphere, and many observed changes are unprecedented in instrumental records. As the changes in the North Atlantic directly affect the climate and air quality of the surrounding continents, it is important to fully understand how and why the changes are taking place, not least to predict how the region will change in the future. To this end, this article characterizes the recent observed changes in the North Atlantic region, especially in the period 2005–2016, across many different aspects of the system including: atmospheric circulation; atmospheric composition; clouds and aerosols; ocean circulation and properties; and the cryosphere. Recent changes include: an increase in the speed of the North Atlantic jet stream in winter; a southward shift in the North Atlantic jet stream in summer, associated with a weakening summer North Atlantic Oscillation; increases in ozone and methane; increases in net absorbed radiation in the mid‐latitude western Atlantic, linked to an increase in the abundance of high level clouds and a reduction in low level clouds; cooling of sea surface temperatures in the North Atlantic subpolar gyre, concomitant with increases in the western subtropical gyre, and a decline in the Atlantic Ocean's overturning circulation; a decline in Atlantic sector Arctic sea ice and rapid melting of the Greenland Ice Sheet. There are many interactions between these changes, but these interactions are poorly understood. This article concludes by highlighting some of the key outstanding questions.

Published
2018

7. Contrasting fast precipitation responses to tropospheric and stratospheric ozone forcing

Author

MacIntosh, C. R., Allan, R. P., Baker, L. H., Bellouin, N., Collins, W, Mousavi, Z., and Shine, K. P.

Abstract

The precipitation response to radiative forcing (RF) can be decomposed into a fast precipitation response (FPR), which depends on the atmospheric component of RF, and a slow response, which depends on surface temperature change. We present the first detailed climate model study of the FPR due to tropospheric and stratospheric ozone changes. The FPR depends strongly on the altitude of ozone change. Increases below about 3 km cause a positive FPR; increases above cause a negative FPR. The FPR due to stratospheric ozone change is, per unit RF, about 3 times larger than that due to tropospheric ozone. As historical ozone trends in the troposphere and stratosphere are opposite in sign, so too are the FPRs. Simple climate model calculations of the time-dependent total (fast and slow) precipitation change, indicate that ozone's contribution to precipitation change in 2011, compared to 1765, could exceed 50% of that due to CO2 change.

Published
2016

8. Evaluating the climate and air quality impacts of short-lived pollutants

Author

Stohl, A., primary, Aamaas, B., additional, Amann, M., additional, Baker, L. H., additional, Bellouin, N., additional, Berntsen, T. K., additional, Boucher, O., additional, Cherian, R., additional, Collins, W., additional, Daskalakis, N., additional, Dusinska, M., additional, Eckhardt, S., additional, Fuglestvedt, J. S., additional, Harju, M., additional, Heyes, C., additional, Hodnebrog, Ø., additional, Hao, J., additional, Im, U., additional, Kanakidou, M., additional, Klimont, Z., additional, Kupiainen, K., additional, Law, K. S., additional, Lund, M. T., additional, Maas, R., additional, MacIntosh, C. R., additional, Myhre, G., additional, Myriokefalitakis, S., additional, Olivié, D., additional, Quaas, J., additional, Quennehen, B., additional, Raut, J.-C., additional, Rumbold, S. T., additional, Samset, B. H., additional, Schulz, M., additional, Seland, Ø., additional, Shine, K. P., additional, Skeie, R. B., additional, Wang, S., additional, Yttri, K. E., additional, and Zhu, T., additional

Published
2015
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10. A randomised controlled trial to compare the clinical and cost-effectiveness of prism glasses, visual search training and standard care in patients with hemianopia following stroke: a protocol.

Author

Rowe, F. J., Barton, P. G., Bedson, E., Breen, R., Conroy, E. J., Cwiklinski, E., Dodridge, C., Drummond, A., Garcia-Finana, M., Howard, C., Johnson, S., MacIntosh, C., Noonan, C. P., Pollock, A., Rockliffe, J., Sackley, C., and Shipman, T.

Abstract

Introduction: Homonymous hemianopia is a common and disabling visual problem after stroke. Currently, prism glasses and visual scanning training are proposed to improve it. The aim of this trial is to determine the effectiveness of these interventions compared to standard care. Methods and analysis: The trial will be a multicentre three arm individually randomised controlled trial with independent assessment at 6 week, 12 week and 26 week post-randomisation. Recruitment will occur in hospital, outpatient and primary care settings in UK hospital trusts. A total of 105 patients with homonymous hemianopia and without ocular motility impairment, visual inattention or pre-existent visual field impairment will be randomised to one of three balanced groups. Randomisation lists will be stratified by site and hemianopia level ( partial or complete) and created using simple block randomisation by an independent statistician. Allocations will be disclosed to patients by the treating clinician, maintaining blinding for outcome assessment. The primary outcome will be change in visual field assessment from baseline to 26 weeks. Secondary measures will include the Rivermead Mobility Index, Visual Function Questionnaire 25/10, Nottingham Extended Activities of Daily Living, Euro Qual-5D and Short Form-12 questionnaires. Analysis will be by intention to treat. Ethics and dissemination: This study has been developed and supported by the UK Stroke Research Network Clinical Studies Group working with service users. Multicentre ethical approval was obtained through the North West 6 Research ethics committee (Reference 10/H1003/119). The trial is funded by the UK Stroke Association. Trial Registration: Current Controlled Trials ISRCTN05956042. Dissemination will consider usual scholarly options of conference presentation and journal publication in addition to patient and public dissemination with lay summaries and articles. [ABSTRACT FROM AUTHOR]

Published
2014
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13. Altimetry for the future: Building on 25 years of progress

Author

Francesco d'Ovidio, Pierre Féménias, Sean Bruinsma, Felix Perosanz, Jerome Bouffard, S. Desai, Alexandre Couhert, Tatyana V. Belonenko, Sinead L. Farrell, Masafumi Kamachi, Rémi Laxenaire, Alexei V. Kouraev, M-Isabelle Pujol, Sandrine Mulet, Ciprian Spatar, Pablo Nilo Garcia, Loren Carrere, Vinca Rosmorduc, Michel Calzas, Marcello Passaro, Francesca Cirillo, Mathieu Hamon, Enrico Ser-Giacomi, Jida Wang, Raj Kumar, Stelios P. Mertikas, Luisella Giulicchi, Eric Jeansou, Benoit Legresy, Corinne Salaün, Donald Richardson, Martin Horwath, Sujit Basu, Rosemary Morrow, Jean-Damien Desjonquères, François Barlier, Cédric Brachet, Cécile Manfredi, Yves Morel, P. K. Gupta, Nicolas Taburet, Ferran Gibert, Anny Cazenave, Sung Yong Kim, Christopher Pearson, Lin Gilbert, Brian D. Dushaw, Johnny A. Johannessen, René Forsberg, Joël Dorandeu, Luciana Fenoglio, Denis Blumstein, C. K. Shum, Debadatta Swain, Stephan Paul, Valerii Vuglinskii, Marco Meloni, Hilary Wilson, Laurent Testut, Sebatian B. Simonsen, John Moyard, Fabien Léger, Andy Shaw, Abdolnabi Abdeh Kolahchi, Andrea Scozzari, Jan Even Øie Nilsen, Anna I. Bulczak, Valerio Poggiali, Rashmi Shah, John Wilkin, Steven Baker, Patrice Klein, Touati Benkouider, Claire Macintosh, Sarah T. Gille, Alexandre Guerin, Gilles Tavernier, Josh K. Willis, Jérôme Benveniste, Cedric Tourain, Emil V. Stanev, Praveen K. Thakur, Lionel Fichen, Céline Tison, Hans Ngodock, Shenfu Dong, Yuanyuan Jia, Sergey A. Lebedev, Nadia Ayoub, Constantin Mavrocordatos, Cédric H. David, Salvatore Dinardo, Yongjun Jia, Berguzar Oztunali Ozbahceci, Sara Fleury, Matthias Raynal, Yannice Faugère, Kathryn A. Kelly, Christian Schwatke, Craig Donlon, Etienne Poirier, Margaret Srinivasan, Remko Scharroo, Helena Antich, Barbara J. Ryan, Sergey V. Prants, Malcolm McMillan, Frédérique Rémy, David T. Sandwell, Annick Sylvestre-baron, Pascal Bonnefond, Fabien Blarel, Mounir Benkiran, Remi Tailleux, Marco Restano, Thierry Guinle, Stefano Vignudelli, Eric Leuliette, Madeleine Cahill, Ali Rami, Saulo Soares, Sophie Le Gac, Bàrbara Barceló-Llull, Claudia C. Carabajal, Veit Helm, Eva Alou-Font, Alejandro Blazquez, David Griffin, Habib B. Dieng, Prakash Chauhan, Albert Garcia-Mondejar, Christian Massari, Christopher J. Banks, Joana Fernandes, Blake A Walter, Nathalie Steunou, Karina Nielsen, Elena Zakharova, Bob Su, Stefania Camici, Frédérique Seyler, Fukai Peng, Denis L. Volkov, Wim Simons, Pieter Visser, Sophie Coutin-Faye, Lionel Gourdeau, Jesús Gómez-Enri, Andreas Schiller, Brian K. Arbic, Svetlana Karimova, Christine Gommenginger, Fanny Piras, Angélique Melet, Steve Coss, Meric Srokosz, Robert G. King, Frédéric Frappart, Fernando S. Paolo, Anna Klos, José Darrozes, Shannon Brown, Loreley Selene Lago, Susheel Adusumilli, Jay F. Shriver, Yves Quilfen, Martina Idžanović, Bernd Uebbing, Daniel Medeiros Moreira, Byron D. Tapley, R. Keith Raney, Frank G. Lemoine, Angelica Tarpanelli, Lara Díaz-Barroso, Jean-François Crétaux, Jean Tournadre, Tamlin M. Pavelsky, Sébastien Trilles, Carolina Nogueira Loddo, Léa Lasson, Stine Kildegaard Rose, Luc Lenain, Philip L. Woodworth, Marie-laure Frery, Saleh Abdalla, Bo Qiu, Stefan Hendricks, Mikhail A. Sokolovskiy, Antonio Sánchez-Román, Martin G. Scharffenberg, Per Knudsen, Andrew Shepherd, Michiel Otten, Sammie Buzzard, Philippe Schaeffer, Nicolas Picot, Luca Brocca, Michel Tsamados, Danielle De Staerke, Frederic Vivier, Nicole Bellefond, Jean-François Minster, Telmo Vieira, Brian D. Beckley, Stylianos Flampouris, Nadya Vinogradova Shiffer, Sergei Rudenko, Camille Noûs, Sabine Arnault, Frédéric Cyr, Liguang Jiang, Nicolas Bercher, Teresa K. Chereskin, Katsumi Takayama, Julienne Stroeve, Andrea Doglioli, Joanna Staneva, Stéphane Calmant, T. Moreau, Julien Le Sommer, David R. Donahue, Nadim Dayoub, Clement Ubelmann, Annie Richardson, Estelle Obligis, Laurent Brodeau, Catherine Prigent, Gérald Dibarboure, Simón Ruiz, LuAnne Thompson, Muriel Berge-Nguyen, Martina Ricko, Hugues Capdeville, Sammy Metref, Roshin P. Raj, Suchandra Aich Bhowmick, Andrey G. Kostianoy, Guillermina Paniagua, Mathilde Cancet, Eero Rinne, Sonia Ponce de León, Cédric Falco, Jianqiang Liu, Lucile Gaultier, Julia Gaudelli, Thierry Medina, Vadim Zinchenko, William Llovel, Eric P. Chassignet, Raymond Zaharia, Svetlana Y. Erofeeva, Lifeng Bao, Ole Baltazar Andersen, Emmanuel Cosme, Anna E. Hogg, Yohanes Budi Sulistioadi, Artur Gil, O. Laurain, Walter H. F. Smith, Ngan Tran, Pierre-Yves Le Traon, Laura Gomez-Navarro, Adrien Paris, Thomas W. K. Armitage, Alejandro Egido, Christopher Watson, João H. Bettencourt, Giuseppe Aulicino, Philippe Escudier, Fangfang Yao, Marco Fornari, Guoqi Han, Florent Lyard, Elisabeth Remy, Lotfi Aouf, Michele Scagliola, Martin Saraceno, Paolo Filippucci, Chao Wang, Zhongxiang Zhao, Juliette Lambin, Evan Mason, Ines Otosaka, Daniele Ciani, Raúl A. Guerrero, Ralf Bennartz, Michael Ablain, Fabrice Hernandez, Xiaoli Deng, John Lillibridge, Oscar Vergara, Marina Levy, Christine Drezen, Pierre Thibaut, Ronan Fablet, Bill Townsend, David Cotton, Sabrina Speich, Clara Lázaro, R. S. Nerem, Danièle Hauser, Pierre Exertier, Yuri Cotroneo, Henryk Dobslaw, Alessandro Di Bella, Karina von Schuckmann, Saskia Esselborn, Benjamin D. Gutknecht, Cecile Marie Margaretha Kittel, Rolf Koenig, Peter Bauer-Gottwein, Franck Borde, Alexander Braun, Christine Provost, Thomas Slater, Laiba Amarouche, Nikolai Maximenko, Raphael Schneider, Victor Zlotnicki, Jacques Verron, Sergei I. Badulin, Andreas Groh, Denise Dettmering, Mark R. Drinkwater, S. Cherchali, Marc Naeije, Fernando Niño, Alessio Domeneghetti, Kuo Hsin Tseng, François Boy, Rashmi Sharma, Laurent Soudarin, Peter A. E. M. Janssen, Robert Ricker, Frédéric Marin, Ananda Pascual, Eduard Makhoul Varona, Yongsheng Zhang, Pierrik Vuilleumier, Louise Sandberg Sørensen, Guillaume Dodet, Pascale Ferrage, Ramiro Ferrari, Yves Du Penhoat, Rodrigo Cauduro Dias de Paiva, S. Labroue, Camila Indira Artana, Joaquín Tintoré, David Brockley, Thierry Penduff, Paolo Cipollini, Augusto Getirana, Cecile Cheymol, Edward D. Zaron, Silvia Barbetta, Pierre Brasseur, Benoit Meyssignac, Matthias Becker, Kehan Yang, Juan Gabriel Fernández, Jean Paul Boy, European Centre for Medium-Range Weather Forecasts (ECMWF), Soil Conservation and Watershed Management Research Institute (SCWRMI), Agricultural Research, Education and Extension Organisation (AREEO ), Scripps Institution of Oceanography (SIO), University of California [San Diego] (UC San Diego), University of California-University of California, Space Applications Centre [Ahmedabad] (SAC), Indian Space Research Organisation (ISRO), Collecte Localisation Satellites (CLS), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National d'Études Spatiales [Toulouse] (CNES), National Space Institute [Lyngby] (DTU Space), Technical University of Denmark [Lyngby] (DTU), Institut Mediterrani d'Estudis Avancats (IMEDEA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de las Islas Baleares (UIB), Météo France, Department of Earth and Environmental Sciences [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Variabilité de l'Océan et de la Glace de mer (VOG), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut de Recherche pour le Développement (IRD)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut de Recherche pour le Développement (IRD)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU), Mercator Océan, Société Civile CNRS Ifremer IRD Météo-France SHOM, Universita degli studi di Napoli 'Parthenope' [Napoli], Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), P.P. Shirshov Institute of Oceanology (SIO), Russian Academy of Sciences [Moscow] (RAS), Department of Space and Climate Physics [UCL London], Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL)-University College of London [London] (UCL), National Oceanography Centre (NOC), Institute of Geodesy and Geophysics [Wuhan], Chinese Academy of Sciences [Wuhan Branch], Istituto di Ricerca per la Protezione Idrogeologica [Perugia] (IRPI), Consiglio Nazionale delle Ricerche [Roma] (CNR), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), DTU Environment, Department of Environmental Engineering, Technische Universität Darmstadt (TU Darmstadt), Centre National d'Études Spatiales [Toulouse] (CNES), St Petersburg State University (SPbU), Agence Spatiale Algérienne = Algerian Space Agency (ASAL), Vanderbilt University [Nashville], European Space Research Institute (ESRIN), European Space Agency (ESA), Centre for Marine Technology and Ocean Engineering (CENTEC), Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), Systèmes de Référence Temps Espace (SYRTE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), European Space Research and Technology Centre (ESTEC), Ecole et Observatoire des Sciences de la Terre (EOST), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), INSU Division Technique de l'INSU [Site de Brest], Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Queen's University [Kingston, Canada], OceanNext, Géosciences Environnement Toulouse (GET), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Institute of Oceanology, Polish Academy of Sciences (IO-PAN), Polska Akademia Nauk = Polish Academy of Sciences (PAN), Centre for Polar Observation and Modelling (CPOM), Natural Environment Research Council (NERC), Australian Institute of Marine Science [Townsville] (AIMS Townsville), Australian Institute of Marine Science (AIMS), NOVELTIS [Sté], Science Systems and Applications, Inc. [Hampton] (SSAI), International Space Science Institute [Bern] (ISSI), Center for Ocean-Atmospheric Prediction Studies (COAPS), Florida State University [Tallahassee] (FSU), Indian Institute of Remote Sensing (IIRS), Istituto di Science Marine (ISMAR ), Consiglio Nazionale delle Ricerche (CNR), European Centre for Space Applications and Telecommunications (ECSAT), Airbus Group [Germany], Airbus [France], School of Earth Sciences [Columbus], Ohio State University [Columbus] (OSU), Satellite Oceanographic Consultants Ltd (SATOC), Northwest Atlantic Fisheries Centre (NWAFC), Fisheries and Oceans Canada (DFO), Processus et interactions de fine échelle océanique (PROTEO), School of Engineering [Callaghan], University of Newcastle [Australia] (UoN), Deutsches Geodätisches Forschungsinstitut (DGFI-TUM), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), SOCIB Balearic Islands Coastal Ocean Observing and Forecasting System, German Research Centre for Geosciences - Helmholtz-Centre Potsdam (GFZ), Laboratoire d'Océanographie Physique et Spatiale (LOPS), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Department of Civil Chemical Environmental and Materials Engineering [Bologna] (DICAM), University of Bologna, NOAA Office of Satellite and Product Operations (OSPO), NOAA National Environmental Satellite, Data, and Information Service (NESDIS), National Oceanic and Atmospheric Administration (NOAA)-National Oceanic and Atmospheric Administration (NOAA), NOAA Atlantic Oceanographic and Meteorological Laboratory (AOML), National Oceanic and Atmospheric Administration (NOAA), Oregon State University (OSU), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT), Département Mathematical and Electrical Engineering (IMT Atlantique - MEE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Equipe Observations Signal & Environnement (Lab-STICC_OSE), Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Université de Perpignan Via Domitia (UPVD), Department of Geographical Sciences [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Institut für Geodäsie und Geoinformationstechnik, Technische Universität Berlin (TU), Interdisciplinary Centre of Marine and Environmental Research [Matosinhos, Portugal] (CIIMAR), Universidade do Porto, Centro de Investigaciones del Mar y la Atmósfera (CIMA), Facultad de Ciencias Exactas y Naturales [Buenos Aires] (FCEyN), Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA)-Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Institut für Planetare Geodäsie, Lohrmann-Observatorium, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Universidad Nacional de Mar del Plata [Mar del Plata] (UNMdP), SPACE - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Environmental Fluid Mechanics Laboratory [Daejeon] (EFML), Korea Advanced Institute of Science and Technology (KAIST), Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA (UMR_8112)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Austral, Boréal et Carbone (ABC), Kansas State University, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), University of Tasmania [Hobart, Australia] (UTAS), Rutgers, The State University of New Jersey [New Brunswick] (RU), Rutgers University System (Rutgers), Institute of Arctic and Alpine Research (INSTAAR), University of Colorado [Boulder], Water Problems Institute (WPI), the Russian Academy of Sciences [Moscow, Russia] (RAS), Portland State University [Portland] (PSU), Applied Physics Laboratory [Seattle] (APL-UW), University of Washington [Seattle], Scripps Institution of Oceanography (SIO - UC San Diego), University of California (UC)-University of California (UC), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Météo-France Direction Interrégionale Sud-Est (DIRSE), Météo-France, Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Università degli Studi di Napoli 'Parthenope' = University of Naples (PARTHENOPE), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Technische Universität Darmstadt - Technical University of Darmstadt (TU Darmstadt), Agence Spatiale Européenne = European Space Agency (ESA), University of Newcastle [Callaghan, Australia] (UoN), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), University of Bologna/Università di Bologna, IMT Atlantique (IMT Atlantique), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique (IMT Atlantique), Technical University of Berlin / Technische Universität Berlin (TU), Universidade do Porto = University of Porto, Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Ciencias Exactas y Naturales [Buenos Aires] (FCEyN), Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres (LERMA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Group on Earth Observations (GEO), Institute of Arctic Alpine Research [University of Colorado Boulder] (INSTAAR), Department of Water Resources, UT-I-ITC-WCC, Faculty of Geo-Information Science and Earth Observation, Abdalla S., Abdeh Kolahchi A., Ablain M., Adusumilli S., Aich Bhowmick S., Alou-Font E., Amarouche L., Andersen O.B., Antich H., Aouf L., Arbic B., Armitage T., Arnault S., Artana C., Aulicino G., Ayoub N., Badulin S., Baker S., Banks C., Bao L., Barbetta S., Barcelo-Llull B., Barlier F., Basu S., Bauer-Gottwein P., Becker M., Beckley B., Bellefond N., Belonenko T., Benkiran M., Benkouider T., Bennartz R., Benveniste J., Bercher N., Berge-Nguyen M., Bettencourt J., Blarel F., Blazquez A., Blumstein D., Bonnefond P., Borde F., Bouffard J., Boy F., Boy J.-P., Brachet C., Brasseur P., Braun A., Brocca L., Brockley D., Brodeau L., Brown S., Bruinsma S., Bulczak A., Buzzard S., Cahill M., Calmant S., Calzas M., Camici S., Cancet M., Capdeville H., Carabajal C.C., Carrere L., Cazenave A., Chassignet E.P., Chauhan P., Cherchali S., Chereskin T., Cheymol C., Ciani D., Cipollini P., Cirillo F., Cosme E., Coss S., Cotroneo Y., Cotton D., Couhert A., Coutin-Faye S., Cretaux J.-F., Cyr F., d'Ovidio F., Darrozes J., David C., Dayoub N., De Staerke D., Deng X., Desai S., Desjonqueres J.-D., Dettmering D., Di Bella A., Diaz-Barroso L., Dibarboure G., Dieng H.B., Dinardo S., Dobslaw H., Dodet G., Doglioli A., Domeneghetti A., Donahue D., Dong S., Donlon C., Dorandeu J., Drezen C., Drinkwater M., Du Penhoat Y., Dushaw B., Egido A., Erofeeva S., Escudier P., Esselborn S., Exertier P., Fablet R., Falco C., Farrell S.L., Faugere Y., Femenias P., Fenoglio L., Fernandes J., Fernandez J.G., Ferrage P., Ferrari R., Fichen L., Filippucci P., Flampouris S., Fleury S., Fornari M., Forsberg R., Frappart F., Frery M.-L., Garcia P., Garcia-Mondejar A., Gaudelli J., Gaultier L., Getirana A., Gibert F., Gil A., Gilbert L., Gille S., Giulicchi L., Gomez-Enri J., Gomez-Navarro L., Gommenginger C., Gourdeau L., Griffin D., Groh A., Guerin A., Guerrero R., Guinle T., Gupta P., Gutknecht B.D., Hamon M., Han G., Hauser D., Helm V., Hendricks S., Hernandez F., Hogg A., Horwath M., Idzanovic M., Janssen P., Jeansou E., Jia Y., Jiang L., Johannessen J.A., Kamachi M., Karimova S., Kelly K., Kim S.Y., King R., Kittel C.M.M., Klein P., Klos A., Knudsen P., Koenig R., Kostianoy A., Kouraev A., Kumar R., Labroue S., Lago L.S., Lambin J., Lasson L., Laurain O., Laxenaire R., Lazaro C., Le Gac S., Le Sommer J., Le Traon P.-Y., Lebedev S., Leger F., Legresy B., Lemoine F., Lenain L., Leuliette E., Levy M., Lillibridge J., Liu J., Llovel W., Lyard F., Macintosh C., Makhoul Varona E., Manfredi C., Marin F., Mason E., Massari C., Mavrocordatos C., Maximenko N., McMillan M., Medina T., Melet A., Meloni M., Mertikas S., Metref S., Meyssignac B., Minster J.-F., Moreau T., Moreira D., Morel Y., Morrow R., Moyard J., Mulet S., Naeije M., Nerem R.S., Ngodock H., Nielsen K., Nilsen J.E.O., Nino F., Nogueira Loddo C., Nous C., Obligis E., Otosaka I., Otten M., Oztunali Ozbahceci B., P. Raj R., Paiva R., Paniagua G., Paolo F., Paris A., Pascual A., Passaro M., Paul S., Pavelsky T., Pearson C., Penduff T., Peng F., Perosanz F., Picot N., Piras F., Poggiali V., Poirier E., Ponce de Leon S., Prants S., Prigent C., Provost C., Pujol M.-I., Qiu B., Quilfen Y., Rami A., Raney R.K., Raynal M., Remy E., Remy F., Restano M., Richardson A., Richardson D., Ricker R., Ricko M., Rinne E., Rose S.K., Rosmorduc V., Rudenko S., Ruiz S., Ryan B.J., Salaun C., Sanchez-Roman A., Sandberg Sorensen L., Sandwell D., Saraceno M., Scagliola M., Schaeffer P., Scharffenberg M.G., Scharroo R., Schiller A., Schneider R., Schwatke C., Scozzari A., Ser-giacomi E., Seyler F., Shah R., Sharma R., Shaw A., Shepherd A., Shriver J., Shum C.K., Simons W., Simonsen S.B., Slater T., Smith W., Soares S., Sokolovskiy M., Soudarin L., Spatar C., Speich S., Srinivasan M., Srokosz M., Stanev E., Staneva J., Steunou N., Stroeve J., Su B., Sulistioadi Y.B., Swain D., Sylvestre-baron A., Taburet N., Tailleux R., Takayama K., Tapley B., Tarpanelli A., Tavernier G., Testut L., Thakur P.K., Thibaut P., Thompson L., Tintore J., Tison C., Tourain C., Tournadre J., Townsend B., Tran N., Trilles S., Tsamados M., Tseng K.-H., Ubelmann C., Uebbing B., Vergara O., Verron J., Vieira T., Vignudelli S., Vinogradova Shiffer N., Visser P., Vivier F., Volkov D., von Schuckmann K., Vuglinskii V., Vuilleumier P., Walter B., Wang J., Wang C., Watson C., Wilkin J., Willis J., Wilson H., Woodworth P., Yang K., Yao F., Zaharia R., Zakharova E., Zaron E.D., Zhang Y., Zhao Z., Zinchenko V., Zlotnicki V., Technical University of Munich (TUM), European Space Agency, National Aeronautics and Space Administration (US), Centre National D'Etudes Spatiales (France), Laboratoire des Écoulements Géophysiques et Industriels [Grenoble] (LEGI), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Sorbonne Université (SU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Sorbonne Université (SU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Lab-STICC_IMTA_CID_TOMS, Université de Brest (UBO)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Université Bretagne Loire (UBL)-Centre National de la Recherche Scientifique (CNRS)-Université de Bretagne Sud (UBS)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Brest (UBO)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Université Bretagne Loire (UBL)-Centre National de la Recherche Scientifique (CNRS)-Université de Bretagne Sud (UBS)-École Nationale d'Ingénieurs de Brest (ENIB), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)

Subjects
Cryospheric science, Atmospheric Science, Earth observation, 010504 meteorology & atmospheric sciences, UT-Hybrid-D, Oceanography, 01 natural sciences, Cryospheric sciences, SDG 13 - Climate Action, Aerospace & Aeronautics, Cryosphere, Satellite altimetry, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, Geodetic datum, ddc, Ocean surface topography, Geophysics, Section (archaeology), [SDE]Environmental Sciences, Astronomical and Space Sciences, Geology, Altimetria espacial, Coastal oceanography, Meteorology, Hidrologia, Aerospace Engineering, ITC-HYBRID, 0103 physical sciences, Geoid, Oceonografia, Sea level, SDG 14 - Life Below Water, 14. Life underwater, Altimeter, Criosfera, Life Below Water, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography, 0105 earth and related environmental sciences, Mechanical Engineering, Hydrology, Astronomy and Astrophysics, Climate Action, Earth system science, [SDU]Sciences of the Universe [physics], 13. Climate action, Space and Planetary Science, ITC-ISI-JOURNAL-ARTICLE, General Earth and Planetary Sciences
Abstract

International Altimetry Team., In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion., At the forefront of this support, we must obviously mention the space agencies CNES, ESA and NASA which have played and still play a decisive role in the development and launch of several prominent altimetry missions from the outset. Other agencies such as DLR, EUMETSAT, ISRO, NOAA, NSOAS and organizations such as CMEMS, also contribute significantly to developments in all forms of altimetry.

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14. Seed Banks as Incidental Fungi Banks: Fungal Endophyte Diversity in Stored Seeds of Banana Wild Relatives.

Author

Hill R, Llewellyn T, Downes E, Oddy J, MacIntosh C, Kallow S, Panis B, Dickie JB, and Gaya E

Abstract

Seed banks were first established to conserve crop genetic diversity, but seed banking has more recently been extended to wild plants, particularly crop wild relatives (CWRs) (e.g., by the Millennium Seed Bank (MSB), Royal Botanic Gardens Kew). CWRs have been recognised as potential reservoirs of beneficial traits for our domesticated crops, and with mounting evidence of the importance of the microbiome to organismal health, it follows that the microbial communities of wild relatives could also be a valuable resource for crop resilience to environmental and pathogenic threats. Endophytic fungi reside asymptomatically inside all plant tissues and have been found to confer advantages to their plant host. Preserving the natural microbial diversity of plants could therefore represent an important secondary conservation role of seed banks. At the same time, species that are reported as endophytes may also be latent pathogens. We explored the potential of the MSB as an incidental fungal endophyte bank by assessing diversity of fungi inside stored seeds. Using banana CWRs in the genus Musa as a case-study, we sequenced an extended ITS-LSU fragment in order to delimit operational taxonomic units (OTUs) and used a similarity and phylogenetics approach for classification. Fungi were successfully detected inside just under one third of the seeds, with a few genera accounting for most of the OTUs-primarily Lasiodiplodia , Fusarium , and Aspergillus -while a large variety of rare OTUs from across the Ascomycota were isolated only once. Fusarium species were notably abundant-of significance in light of Fusarium wilt, a disease threatening global banana crops-and so were targeted for additional sequencing with the marker EF1α in order to delimit species and place them in a phylogeny of the genus. Endophyte community composition, diversity and abundance was significantly different across habitats, and we explored the relationship between community differences and seed germination/viability. Our results show that there is a previously neglected invisible fungal dimension to seed banking that could well have implications for the seed collection and storage procedures, and that collections such as the MSB are indeed a novel source of potentially useful fungal strains., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Hill, Llewellyn, Downes, Oddy, MacIntosh, Kallow, Panis, Dickie and Gaya.)

Published
2021
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15. Bio-assembling Macro-Scale, Lumenized Airway Tubes of Defined Shape via Multi-Organoid Patterning and Fusion.

Author

Liu Y, Dabrowska C, Mavousian A, Strauss B, Meng F, Mazzaglia C, Ouaras K, Macintosh C, Terentjev E, Lee JH, and Huang YYS

Subjects
Animals, Biomimetics, Cell Fusion, Mice, Models, Animal, Stem Cells, Morphogenesis physiology, Organoids growth & development, Tissue Culture Techniques methods, Tissue Engineering methods, Trachea physiology
Abstract

Epithelial, stem-cell derived organoids are ideal building blocks for tissue engineering, however, scalable and shape-controlled bio-assembly of epithelial organoids into larger and anatomical structures is yet to be achieved. Here, a robust organoid engineering approach, Multi-Organoid Patterning and Fusion (MOrPF), is presented to assemble individual airway organoids of different sizes into upscaled, scaffold-free airway tubes with predefined shapes. Multi-Organoid Aggregates (MOAs) undergo accelerated fusion in a matrix-depleted, free-floating environment, possess a continuous lumen, and maintain prescribed shapes without an exogenous scaffold interface. MOAs in the floating culture exhibit a well-defined three-stage process of inter-organoid surface integration, luminal material clearance, and lumina connection. The observed shape stability of patterned MOAs is confirmed by theoretical modelling based on organoid morphology and the physical forces involved in organoid fusion. Immunofluorescent characterization shows that fused MOA tubes possess an unstratified epithelium consisting mainly of tracheal basal stem cells. By generating large, shape-controllable organ tubes, MOrPF enables upscaled organoid engineering towards integrated organoid devices and structurally complex organ tubes., Competing Interests: The authors declare no conflict of interest., (© 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH.)

Published
2021
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16. A Randomised Controlled Trial of Treatment for Post-Stroke Homonymous Hemianopia: Screening and Recruitment.

Author

Rowe FJ, Conroy EJ, Barton PG, Bedson E, Cwiklinski E, Dodridge C, Drummond A, Garcia-Finana M, Howard C, Johnson S, MacIntosh C, Noonan CP, Pollock A, Rockliffe J, Sackley CM, and Shipman T

Abstract

The authors report the screening process and recruitment figures for the VISION (Visual Impairment in Stroke; Intervention Or Not) trial. This is a prospective, randomised, single-blinded, three-arm controlled trial in 14 UK acute hospital stroke units. Stroke teams identified stroke survivors suspected as having homonymous hemianopia. Interventions included Fresnel prisms versus visual search training versus standard care (information only). Primary outcome was change in visual field assessment from baseline to 26 weeks. Secondary measures included change in quality-of-life questionnaires. Recruitment opened in May 2011. A total of 1171 patients were screened by the local principal investigators. Of 1171 patients, 178 (15.2%) were eligible for recruitment: 87 patients (7.4%) provided consent and were recruited; 91 patients (7.8%) did not provide consent, and 993 of 1171 patients (84.8%) failed to meet the eligibility criteria. Almost half were excluded due to complete/partial recovery of hemianopia (43.6%; n = 511). The most common ineligibility reason was recovery of hemianopia. When designing future trials in this area, changes in eligibility criteria/outcome selection to allow more patients to be recruited should be considered, e.g., less stringent levels of visual acuity/refractive error. Alternative outcomes measurable in the home environment, rather than requiring hospital attendance for follow-up, could facilitate increased recruitment.

Published
2016
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17. Updating the Simulation Effectiveness Tool: Item Modifications and Reevaluation of Psychometric Properties.

Author

Leighton K, Ravert P, Mudra V, and Macintosh C

Subjects
Adult, Clinical Competence, Cross-Sectional Studies, Educational Measurement, Female, Humans, Male, Models, Educational, Nursing Education Research, Surveys and Questionnaires, Education, Nursing, Baccalaureate methods, Manikins, Psychometrics, Students, Nursing psychology
Abstract

Aim: This study evaluated the psychometric properties of the modified Simulation Effectiveness Tool (SET), the SET-M., Background: The SET, developed in 2005, was updated to be consistent with INACSL Standards of Best Practice, QSEN practices, and American Association of Colleges of Nursing baccalaureate essentials., Method: Undergraduate nursing students from two nursing programs, one with multiple campuses, completed the SET-M following completion of a simulated clinical experience; 1,288 students took part in the study., Results: Exploratory factor analysis was completed using unweighted least squares. Four subscales were identified with acceptable internal consistency: Prebriefing (α = .833), Learning (α = .852), Confidence (α = .913), and Debriefing (α = .908)., Conclusion: Revisions made to modify the SET to current standards of simulation practice have resulted in the SET-M, which has been shown to be a valid and reliable method of evaluating students' perceptions of the effectiveness of learning in the simulation environment.

Published
2015
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18. Identification of cross-country skiing movement patterns using micro-sensors.

Author

Marsland F, Lyons K, Anson J, Waddington G, Macintosh C, and Chapman D

Abstract

This study investigated the potential of micro-sensors for use in the identification of the main movement patterns used in cross-country skiing. Data were collected from four elite international and four Australian athletes in Europe and in Australia using a MinimaxX™ unit containing accelerometer, gyroscope and GPS sensors. Athletes performed four skating techniques and three classical techniques on snow at moderate velocity. Data from a single micro-sensor unit positioned in the centre of the upper back was sufficient to visually identify cyclical movement patterns for each technique. The general patterns for each technique were identified clearly across all athletes while at the same time distinctive characteristics for individual athletes were observed. Differences in speed, snow condition and gradient of terrain were not controlled in this study and these factors could have an effect on the data patterns. Development of algorithms to process the micro-sensor data into kinematic measurements would provide coaches and scientists with a valuable performance analysis tool. Further research is needed to develop such algorithms and to determine whether the patterns are consistent across a range of different speeds, snow conditions and terrain, and for skiers of differing ability.

Published
2012
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19. Mapping nursing program activities to nursing informatics competencies.

Author

Jones K, Kapsandoy S, Macintosh C, and Wyckoff A

Subjects
Curriculum, Nurses, Utah, Education, Nursing methods, Educational Measurement, Nursing Informatics education, Professional Competence statistics & numerical data
Abstract

In order to facilitate the incorporation of Informatics competencies into nursing curricula, this group analyzed the course content of three BSN level nursing classes and correlated appropriate competencies to the course content. The two main areas of focus were competencies already used and competencies easily incorporated.

Published
2008

20. Differentiation of prostate epithelial cell cultures by matrigel/ stromal cell glandular reconstruction.

Author

Lang SH, Smith J, Hyde C, Macintosh C, Stower M, and Maitland NJ

Subjects
Cell Culture Techniques, Cell Line, Cell Line, Tumor, Cell Shape, Coculture Techniques, Drug Combinations, Epithelial Cells virology, Human papillomavirus 16 genetics, Humans, Male, Phenotype, Prostate virology, Prostatic Neoplasms pathology, Cell Differentiation, Collagen, Epithelial Cells cytology, Laminin, Prostate cytology, Proteoglycans, Spheroids, Cellular cytology, Stromal Cells cytology
Abstract

Three-dimensional epithelial culture models are widely used to emulate a more physiologically relevant microenvironment for the study of genes and signaling pathways. Prostate epithelial cells can grow into solid cell masses or acinus-like spheroids in Matrigel. To test if the ability to form acinus-like spheroids in Matrigel is dependent on how undifferentiated a cell is or whether it is tumor or nontumor, we established six novel epithelial cell lines. Primary prostate epithelial cells were immortalized using HPV16 E6 gene transduction and were named Shmac 2, 3, and 6 (nontumor); Shmac 4, Shmac 5, and P4E6 (tumor). All cell lines were phenotyped in monolayer culture, and their ability to form acinus-like spheroids in Matrigel investigated. The cell lines exhibited a wide range of population doubling times and all showed an intermediate phenotype in monolayer culture ((luminal)CK(+)/(basal)CK(+)/CD44(+)/PSA(+)/AR(-)). Only Shmac 5 cells formed acinus-like spheroids when cultured in Matrigel. Co-culture of the spheroids with fibroblasts advanced differentiation by inducing androgen receptor expression and epithelial polarization. Our findings indicate that tumor cells can form acinus-like spheroids in Matrigel.

Published
2006
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21. Effects of glucose supplementation on gastric emptying, blood glucose homeostasis, and appetite in the elderly.

Author

Beckoff K, MacIntosh CG, Chapman IM, Wishart JM, Morris HA, Horowitz M, and Jones KL

Subjects
Aged, 80 and over, Appetite drug effects, Dietary Fats, Unsaturated pharmacology, Energy Intake drug effects, Female, Gastric Emptying drug effects, Gastric Inhibitory Polypeptide blood, Glucagon blood, Glucagon-Like Peptide 1, Homeostasis, Humans, Insulin blood, Kinetics, Male, Olive Oil, Peptide Fragments blood, Plant Oils pharmacology, Protein Precursors blood, Regression Analysis, Time Factors, Aged physiology, Appetite physiology, Blood Glucose metabolism, Dietary Carbohydrates, Energy Intake physiology, Gastric Emptying physiology, Glucose pharmacology
Abstract

The aims of this study were to evaluate the effects of dietary glucose supplementation on gastric emptying (GE) of both glucose and fat, postprandial blood glucose homeostasis, and appetite in eight older subjects (4 males, 4 females, aged 65--84 yr). GE of a drink (15 ml olive oil and 33 g glucose dissolved in 185 ml water), blood glucose, insulin, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and appetite (diet diaries, visual analog scales, and food intake at a buffet meal consumed after the GE study) were evaluated twice, after 10 days on a standard or a glucose-supplemented diet (70 g glucose 3 times a day). Glucose supplementation accelerated GE of glucose (P < 0.05), but not oil; there was a trend for an increase in GIP (at 15 min, P = 0.06), no change in GLP-1, an earlier insulin peak (P < 0.01), and a subsequent reduction in blood glucose (at 75 min, P < 0.01). Glucose supplementation had no effect on food intake during each diet so that energy intake was greater (P < 0.001) during the glucose-supplemented diet. Appetite ratings and energy intake at the buffet meal were not different. We conclude that, in older subjects, glucose supplementation 1) accelerates GE of glucose, but not fat; 2) modifies postprandial blood glucose homeostasis; and 3) increases energy intake.

Published
2001
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22. In vitro models to study cellular differentiation and function in human prostate cancers.

Author

Maitland NJ, Macintosh CA, Hall J, Sharrard M, Quinn G, and Lang S

Subjects
Allelic Imbalance, Carboxypeptidases genetics, Cell Differentiation physiology, Cell Transformation, Viral, Chromosomes, Human, Pair 8 genetics, Epithelial Cells pathology, Epithelial Cells physiology, Glutamate Carboxypeptidase II, Humans, Male, Oncogene Proteins, Viral genetics, Open Reading Frames, Papillomaviridae genetics, Phenotype, Promoter Regions, Genetic, Prostate-Specific Antigen genetics, Prostatic Neoplasms genetics, Prostatic Neoplasms metabolism, Transfection, Antigens, Surface, Prostatic Neoplasms pathology, Repressor Proteins, Tumor Cells, Cultured
Abstract

In Vitro Models to Study Cellular Differentiation and Function in Human Prostate Cancers. To augment the currently available models of human prostate cancer in vitro, we have established extended life-span epithelial cultures from biopsies of well-differentiated prostate cancers. The genetic identity of the target cells was assessed by allelotyping, using microsatellites located on chromosome 8p, and microdissection of tissues and primary cell cultures. Cells with an extended life span (PxE6) were derived by recombinant retrovirus infection to introduce the human papilloma virus E6 gene (epithelial cells). Immunophenotyping of the resultant cell strains confirmed retention of differentiated cell functions, and the genotype of the E6-expressing epithelial cells was stable, while SV40-immortalized cultures were more unstable, leading to tetraploidy. All PxE6 cells eventually senesced, but an immortalized epithelial culture, P4E6, was derived from one of the epithelial cultures. The properties of this cell line, which remains close to diploid, are similar to those of early prostate cancer cells, and it retains expression of many prostate-associated antigens, such as prostate-specific antigen (PSA).

Published
2001
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23. Evaluation of computer based clinical decision support system and risk chart for management of hypertension in primary care: randomised controlled trial.

Author

Montgomery AA, Fahey T, Peters TJ, MacIntosh C, and Sharp DJ

Subjects
Aged, Algorithms, Evaluation Studies as Topic, Female, Humans, Male, Middle Aged, Practice Guidelines as Topic, Risk Assessment methods, Decision Making, Computer-Assisted, Decision Support Systems, Clinical, Hypertension drug therapy, Primary Health Care methods
Abstract

Objectives: To investigate the effect of a computer based clinical decision support system and a risk chart on absolute cardiovascular risk, blood pressure, and prescribing of cardiovascular drugs in hypertensive patients., Design: Cluster randomised controlled trial., Setting: 27 general practices in Avon., Participants: 614 patients aged between 60 and 79 years with high blood pressure., Interventions: Patients were randomised to computer based clinical decision support system plus cardiovascular risk chart; cardiovascular risk chart alone; or usual care., Main Outcome Measures: Percentage of patients in each group with a five year cardiovascular risk >/=10%, systolic blood pressure, diastolic blood pressure, prescribing of cardiovascular drugs., Results: Patients in the computer based clinical decision support system and chart only groups were no more likely to have cardiovascular risk reduced to below 10% than patients receiving usual care. Patients in the computer based clinical decision support group were more likely to have a cardiovascular risk >/=10% than chart only patients, odds ratio 2.3 (95% confidence interval 1.1 to 4.8). The chart only group had significantly lower systolic blood pressure compared with the usual care group (difference in means -4.6 mm Hg (95% confidence interval -8.4 to -0.8)). Reduction of diastolic blood pressure did not differ between the three groups. The chart only group were twice as likely to be prescribed two classes of cardiovascular drugs and over three times as likely to be prescribed three or more classes of drugs compared with the other groups., Conclusions: The computer based clinical decision support system did not confer any benefit in absolute risk reduction or blood pressure control and requires further development and evaluation before use in clinical care can be recommended. Use of chart guidelines are associated with a potentially important reduction in systolic blood pressure.

Published
2000
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24. Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility.

Author

MacIntosh CG, Andrews JM, Jones KL, Wishart JM, Morris HA, Jansen JB, Morley JE, Horowitz M, and Chapman IM

Subjects
Adult, Aged, Aged, 80 and over, Duodenum, Fats pharmacology, Gastric Emptying, Glucagon-Like Peptide 1, Glucose pharmacology, Humans, Male, Aging blood, Appetite, Cholecystokinin blood, Glucagon blood, Peptide Fragments blood, Peptide YY blood, Protein Precursors blood
Abstract

Background: Aging is associated with a decrease in appetite and a slowing of gastric emptying. The gastrointestinal hormones cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) may mediate these changes., Objective: We investigated whether aging influenced the secretion of CCK, GLP-1, and PYY and their effects on appetite and pyloric motility., Design: Eight healthy older (65-80 y) and 7 younger (20-34 y) men received isoenergetic (12.1 kJ/min) intraduodenal infusions of lipid and glucose for 120 min on separate days. Plasma CCK, GLP-1, and PYY concentrations were measured., Results: Plasma CCK concentrations were higher in older than in younger subjects (P = 0.004) as a result of higher baseline values (4.7+/-0.2 compared with 3.2+/-0.2 pmol/L; P < 0.0001) and a greater rise during lipid infusion (increase from baseline: 7.1+/-0.5 compared with 5.3+/-0.6 pmol/L; P = 0.048). Plasma GLP-1 and PYY concentrations were not significantly different between groups. The decrease in hunger during intraduodenal lipid infusion was inversely related to the increase in CCK, GLP-1, and PYY in younger but not older subjects. During intraduodenal lipid infusion, the increase in isolated pyloric pressure wave (IPPW) frequency was positively related to GLP-1 and PYY and the increase in IPPW amplitude was positively related to CCK in older but not younger subjects, whereas the increase in IPPW amplitude and pyloric tone was negatively related to GLP-1 and PYY in younger subjects., Conclusions: Human aging is associated with increased CCK concentrations, which may contribute to the slowing of gastric emptying, mediated by increased pyloric motility. The role of increased plasma CCK concentrations in mediating the age-related decrease in appetite remains to be established.

Published
1999
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25. Precise microdissection of human prostate cancers reveals genotypic heterogeneity.

Author

Macintosh CA, Stower M, Reid N, and Maitland NJ

Subjects
Chromosomes, Human, Pair 8 genetics, Dissection methods, Genetic Markers, Genotype, Humans, Male, Polymerase Chain Reaction, Prostatic Neoplasms pathology, Loss of Heterozygosity, Prostatic Neoplasms genetics
Abstract

To determine the incidence of genetic heterogeneity in primary prostate cancer, we have microdissected 125 tumor and mesenchymal foci from 18 patient biopsies and analyzed the DNA for loss of heterozygosity using PCR microsatellite markers. In 100% of patients with genetic lesions on chromosome 8p, there was evidence for intratumoral genetic heterogeneity. There was also a low but significant incidence of loss of heterozygosity in mesenchymal tissue. Our results show that phenotypically similar tumor foci can have different genotypes and provide evidence for the multifocality of tumor development in the prostate.

Published
1998

26. Quality of life for patients in an end-stage renal disease programme.

Author

Seedat YK, MacIntosh CG, and Subban JV

Subjects
Activities of Daily Living, Adolescent, Adult, Aged, Child, Depression, Employment, Female, Humans, Kidney Failure, Chronic complications, Kidney Failure, Chronic psychology, Kidney Transplantation, Male, Middle Aged, Peritoneal Dialysis, Continuous Ambulatory, Renal Dialysis, Sex, Kidney Failure, Chronic therapy, Quality of Life
Abstract

A group of 128 patients in an end-stage renal disease programme in Natal was studied in order to assess the relative success of the different treatment modalities in achieving optimal patient rehabilitation in regard to employability and social, psychological and medical status. Confirmation that successful transplantation achieves the best quality of life was obtained.

Published
1987

27. Latent silicosis.

Author

McQUITTY M, CUDDIHY B, MacINTOSH CA, and ADAMS GT

Subjects
Humans, Pneumoconiosis, Silicosis
Published
1950

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